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Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)
Int J Mol Med. 2024 May;53(5):41. doi: 10.3892/ijmm.2024.5365. Epub 2024 Mar 8.ABSTRACTCircular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, ...
Source: International Journal of Molecular Medicine - March 8, 2024 Category: Molecular Biology Authors: Wanlu Ye Nan Xiang Qing Wang Yanming Lu Source Type: research

Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research

[Corrigendum] Bax inhibitor ‑1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. Epub 2024 Mar 1.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 6 on p. 2898, the 'SAH' and 'SAH+NC' data panels contained an apparently overlapping section of data, such that these data appeared to have been derived from the same original source, even though they were intended to show the results from differently performed experiments. The authors have examined their original data, and realize that the 'SAH+NC' data panel had inadvertently been selected incorrectly for this figure. In ad...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Jiaxin Liu Shuai Zhou Yueting Zhang Xiuying Li Xiying Qian Weihua Tao Lide Jin Jianhua Zhao Source Type: research

Cytoplasmic localization of SETDB1 ‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma
In conclusion, subcellular localization of cytoplasmic SETDB1 may be a pivotal factor in breast cancer progression. The present study offers valuable insight into the novel functions and mechanisms of cytoplasmic SETDB1.PMID:38426579 | PMC:PMC10914311 | DOI:10.3892/ijmm.2024.5364 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Wenlin Yang Yingze Wei Ting Wang Ying Xu Xiaoxia Jin Hongyan Qian Shuyun Yang Song He Source Type: research

Adipocyte ‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer
Int J Mol Med. 2024 Apr;53(4):37. doi: 10.3892/ijmm.2024.5361. Epub 2024 Mar 1.ABSTRACTThe effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance. Bioinformatics analysis was used to explore the effects of ARM‑associated mechanisms contributing to chemoresistance and treated EOC cells, prima...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Siqi Chen Zixuan Liu Haixia Wu Bo Wang Yuqing Ouyang Junru Liu Xiaoyan Zheng Haoke Zhang Xueying Li Xiaofan Feng Yan Li Yangyang Shen Hong Zhang Bo Xiao Chunyan Yu Weimin Deng Source Type: research

Cytoplasmic localization of SETDB1 ‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma
In conclusion, subcellular localization of cytoplasmic SETDB1 may be a pivotal factor in breast cancer progression. The present study offers valuable insight into the novel functions and mechanisms of cytoplasmic SETDB1.PMID:38426579 | DOI:10.3892/ijmm.2024.5364 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Wenlin Yang Yingze Wei Ting Wang Ying Xu Xiaoxia Jin Hongyan Qian Shuyun Yang Song He Source Type: research