International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor ‑associated macrophages
Int J Mol Med. 2024 Jan;53(1):3. doi: 10.3892/ijmm.2023.5327. Epub 2023 Nov 8.ABSTRACTTumor‑associated macrophages (TAMs) are pivotal components in colorectal cancer (CRC) progression, markedly influencing the tumor microenvironment through their polarization into the pro‑inflammatory M1 or pro‑tumorigenic M2 phenotypes. Recent studies have highlighted that the Grb2‑associated binder 2 (Gab2) is a critical gene involved in the development of various types of tumor, including CRC. However, the precise role of Gab2 in mediating TAM polarization remains incompletely elucidated. In the present study, it was discovered ...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Xuehan Gao Runying Long Ming Qin Wenfang Zhu Linna Wei Pinzhi Dong Jin Chen Junmin Luo Jihong Feng Source Type: research

Single ‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)
Int J Mol Med. 2024 Jan;53(1):2. doi: 10.3892/ijmm.2023.5326. Epub 2023 Nov 8.ABSTRACTOsteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration, secondary bone hyperplasia, inadequate extracellular matrix synthesis and degeneration of articular cartilage. Mesenchymal stem cells (MSCs) can self‑renew and undergo multidirectional differentiation; they can differentiate into chondrocytes. Aging MSCs have a weakened ability to differentiate, and release various pro‑inflammatory cytokines, which may contribute to OA progression; the other mechanism contributing to OA is epigenetic regu...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Dunyong Tan Zeqi Huang Zhe Zhao Xiaoqiang Chen Jianquan Liu Daping Wang Zhiqin Deng Wencui Li Source Type: research

Bone marrow mesenchymal stem cell ‑derived exosomes: A novel therapeutic agent for tendon‑bone healing (Review)
Int J Mol Med. 2023 Dec;52(6):121. doi: 10.3892/ijmm.2023.5324. Epub 2023 Nov 8.ABSTRACTIn sports medicine, injuries related to the insertion of tendons into bones, including rotator cuff injuries, anterior cruciate ligament injuries and Achilles tendon ruptures, are commonly observed. However, traditional therapies have proven to be insufficient in achieving satisfactory outcomes due to the intricate anatomical structure associated with these injuries. Adult bone marrow mesenchymal stem cells possess self‑renewal and multi‑directional differentiation potential and can generate various mesenchymal tissues to aid in the...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yongjia Zhu Jiapeng Yan Hongfei Zhang Guanxing Cui Source Type: research

[Retracted] Downregulation of long non ‑coding RNA GACAT1 suppresses proliferation and induces apoptosis of NSCLC cells by sponging microRNA‑422a
Int J Mol Med. 2024 Jan;53(1):1. doi: 10.3892/ijmm.2023.5325. Epub 2023 Nov 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the flow cytometric data shown in Fig. 2E on p. 662 were strikingly similar to data appearing in different form in a pair of other research articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been submitted for publication elsewhere prior to its submission to International Journal of Molecular Medicine, the Editor has decided that this pa...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Youqing Zhong Hui Lin Qi Li Chang Liu Lei Zhong Source Type: research