International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Low ‑intensity pulsed ultrasound accelerates diabetic wound healing by ADSC‑derived exosomes via promoting the uptake of exosomes and enhancing angiogenesis
Int J Mol Med. 2024 Mar;53(3):23. doi: 10.3892/ijmm.2024.5347. Epub 2024 Jan 12.ABSTRACTDiabetic wounds remain a great challenge for clinicians globally as a lack of effective radical treatment often results in poor prognosis. Exosomes derived from adipose‑derived stem cells (ADSC‑Exos) have been explored as an appealing nanodrug delivery system in the treatment of diabetic wounds. However, the short half‑life and low utilization efficiency of exosomes limit their therapeutic effects. Low‑intensity pulsed ultrasound (LIPUS) provides a non‑invasive mechanical stimulus to cells and exerts a number of biological eff...
Source: International Journal of Molecular Medicine - January 12, 2024 Category: Molecular Biology Authors: Fanglu Zhong Sheng Cao Li Yang Junbi Liu Bin Gui Hao Wang Nan Jiang Qing Zhou Qing Deng Source Type: research

Regulator of G protein signalling 18 promotes osteocyte proliferation by activating the extracellular signal ‑regulated kinase signalling pathway
In conclusion, RGS18 may contribute to osteocyte proliferation and bone fracture healing via activation of ERK signalling.PMID:38214344 | PMC:PMC10836495 | DOI:10.3892/ijmm.2024.5346 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - January 12, 2024 Category: Molecular Biology Authors: Yong Meng Si-Qiang Qiu Qiang Wang Jin-Liang Zuo Source Type: research

[Retracted] Upregulation of miR ‑183‑5p is responsible for the promotion of apoptosis and inhibition of the epithelial‑mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin
Int J Mol Med. 2024 Mar;53(3):21. doi: 10.3892/ijmm.2024.5345. Epub 2024 Jan 12.ABSTRACTFollowing the publication of this article, a concerned reader drew to the Editor's attention that, in Fig. 9C on p. 2478 showing the results of Transwell invasion assay experiments, unexpected areas of similarity were identified in terms of the cellular patterns revealed both within the data panels for the six different experiments portrayed in this figure, and comparing among them. After having conducted an internal investigation, the Editor of International Journal of Molecular Medicine has reached the conclusion that the overlapping ...
Source: International Journal of Molecular Medicine - January 12, 2024 Category: Molecular Biology Authors: Hua Yan Bing-Mei Sun Yu-Ying Zhang Yu-Juan Li Cheng-Xiang Huang Fu-Zhong Feng Cui Li Source Type: research

Combination of the cuproptosis inducer disulfiram and anti ‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway
In conclusion, the combined treatment of A549 cells with anti‑PD‑L1 and DSF enhanced the effect of cuproptosis on the inhibition of NSCLC cell viability.PMID:38186308 | PMC:PMC10781418 | DOI:10.3892/ijmm.2023.5343 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - January 8, 2024 Category: Molecular Biology Authors: Pengfei Li Qi Sun Shuping Bai Haitao Wang Ling Zhao Source Type: research

Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in non ‑alcoholic fatty liver disease
Int J Mol Med. 2024 Feb;53(2):18. doi: 10.3892/ijmm.2023.5342. Epub 2024 Jan 8.ABSTRACTAlthough some clinical studies have reported increased mitochondrial respiration in patients with fatty liver and early non‑alcoholic steatohepatitis (NASH), there is a lack of in vitro models of non‑alcoholic fatty liver disease (NAFLD) with similar findings. Despite being the most commonly used immortalized cell line for in vitro models of NAFLD, HepG2 cells exposed to free fatty acids (FFAs) exhibit a decreased mitochondrial respiration. On the other hand, the use of HepaRG cells to study mitochondrial respiratory changes followin...
Source: International Journal of Molecular Medicine - January 8, 2024 Category: Molecular Biology Authors: Tumisang Edward Maseko Moustafa Elkalaf Eva Peterov á Halka Lotkov á Pavla Sta ňková Jan Melek Jan Du šek Petra Žádníková Dana Čížková Ale š Bezrouk Petr P ávek Zuzana Červinková Otto Ku čera Source Type: research

Association of endometriosis with Sj ögren's syndrome: Genetic insights (Review)
Int J Mol Med. 2024 Feb;53(2):20. doi: 10.3892/ijmm.2024.5344. Epub 2024 Jan 8.ABSTRACTPatients with a history of endometriosis have an increased risk of developing various autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis and celiac disease. There is a potential association between endometriosis and an increased susceptibility for Sjögren's syndrome (SS). SS is a common chronic, inflammatory, systemic, autoimmune, multifactorial disease of complex pathology, with genetic, epigenetic and environmental factors contributing to the development of this c...
Source: International Journal of Molecular Medicine - January 8, 2024 Category: Molecular Biology Authors: Maria I Zervou Basil C Tarlatzis Grigoris F Grimbizis Demetrios A Spandidos Timothy B Niewold George N Goulielmos Source Type: research

Combination of the cuproptosis inducer disulfiram and anti ‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway
In conclusion, the combined treatment of A549 cells with anti‑PD‑L1 and DSF enhanced the effect of cuproptosis on the inhibition of NSCLC cell viability.PMID:38186308 | DOI:10.3892/ijmm.2023.5343 (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - January 8, 2024 Category: Molecular Biology Authors: Pengfei Li Qi Sun Shuping Bai Haitao Wang Ling Zhao Source Type: research

Deciphering the emerging landscape of HOX genes in cardiovascular biology, atherosclerosis and beyond (Review)
Int J Mol Med. 2024 Feb;53(2):17. doi: 10.3892/ijmm.2023.5341. Epub 2023 Dec 22.ABSTRACTAtherosclerosis, a dominant driving force underlying multiple cardiovascular events, is an intertwined and chronic inflammatory disease characterized by lipid deposition in the arterial wall, which leads to diverse cardiovascular problems. Despite unprecedented advances in understanding the pathogenesis of atherosclerosis and the substantial decline in cardiovascular mortality, atherosclerotic cardiovascular disease remains a global public health issue. Understanding the molecular landscape of atherosclerosis is imperative in the field ...
Source: International Journal of Molecular Medicine - December 22, 2023 Category: Molecular Biology Authors: Yu Zhou Qiang Wu Yingchu Guo Source Type: research