International Journal of Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

mROS ‑calcium feedback loop promotes lethal ventricular arrhythmias and sudden cardiac death in early myocardial ischemia
Int J Mol Med. 2024 Jan;53(1):5. doi: 10.3892/ijmm.2023.5329. Epub 2023 Nov 24.ABSTRACTLethal ventricular arrhythmia‑sudden cardiac death (LVA‑SCD) occurs frequently during the early stage of myocardial ischemia (MI). However, the mechanism underlying higher LVA‑SCD incidence is still poorly understood. The present study aimed to explore the role of mitochondrial reactive oxygen species (mROS) and Ca2+ crosstalk in promoting LVA‑SCD in early MI. RyR2 S2814A mice and their wild‑type littermates were used. MitoTEMPO was applied to scavenge mitochondrial ROS (mROS). Mice were subjected to severe MI and the occurrenc...
Source: International Journal of Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: Danya Zhou Ye Zhang Mengting Zhu Xiaojun Zhang Xiaojuan Zhang Junyao Lv Wanting Tang Qi Weng Yang Lin Lejun Tong Zhiwei Zhong Yanmei Zhang Mengxuan Zhang Minchao Lai Dian Wang Source Type: research

Roles of vitamin K ‑dependent protein in biomineralization (Review)
Int J Mol Med. 2024 Jan;53(1):6. doi: 10.3892/ijmm.2023.5330. Epub 2023 Nov 24.ABSTRACTVitamin K (VK), a fat‑soluble vitamin, is well known as an anticoagulant in the clinic. It is essential for the post‑translational activation of VK‑dependent proteins (VKDPs) because hydroquinone VK is a cofactor of glutamine carboxylase. At present, 17 VKDPs are known, which are mainly involved in coagulation and calcification. When Glu residues are carboxylated to Gla residues, these proteins gain a higher calcium‑binding ability, which explains why VK has an important role in blood coagulation and biomineralization. However, t...
Source: International Journal of Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: Meng Zhang Qingqi Zhang Pengfei Du Xin Chen Yumei Zhang Source Type: research

Inhibition of HDAC6 alleviates cancer ‑induced bone pain by reducing the activation of NLRP3 inflammasome
Int J Mol Med. 2024 Jan;53(1):4. doi: 10.3892/ijmm.2023.5328. Epub 2023 Nov 24.ABSTRACTCancer‑induced bone pain (CIBP) is characterized as moderate to severe pain that negatively affects the daily functional status and quality of life of patients. When cancer cells metastasize and grow in bone marrow, this activates neuroinflammation in the spinal cord, which plays a vital role in the generation and persistence of chronic pain. In the present study, a model of CIBP was constructed by inoculating of MRMT‑1 rat breast carcinoma cells into the medullary cavity of the tibia in male Sprague‑Dawley rats. Following two week...
Source: International Journal of Molecular Medicine - November 24, 2023 Category: Molecular Biology Authors: Yin-Di Hu Zhao-Di Wang Yuan-Fen Yue Dai Li Shu-Qing Zhen Jie-Qiong Ding Wei Meng Hai-Li Zhu Min Xie Ling Liu Source Type: research

[Retracted] Downregulation of long non ‑coding RNA GACAT1 suppresses proliferation and induces apoptosis of NSCLC cells by sponging microRNA‑422a
Int J Mol Med. 2024 Jan;53(1):1. doi: 10.3892/ijmm.2023.5325. Epub 2023 Nov 8.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the flow cytometric data shown in Fig. 2E on p. 662 were strikingly similar to data appearing in different form in a pair of other research articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been submitted for publication elsewhere prior to its submission to International Journal of Molecular Medicine, the Editor has decided that this pa...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Youqing Zhong Hui Lin Qi Li Chang Liu Lei Zhong Source Type: research

Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor ‑associated macrophages
Int J Mol Med. 2024 Jan;53(1):3. doi: 10.3892/ijmm.2023.5327. Epub 2023 Nov 8.ABSTRACTTumor‑associated macrophages (TAMs) are pivotal components in colorectal cancer (CRC) progression, markedly influencing the tumor microenvironment through their polarization into the pro‑inflammatory M1 or pro‑tumorigenic M2 phenotypes. Recent studies have highlighted that the Grb2‑associated binder 2 (Gab2) is a critical gene involved in the development of various types of tumor, including CRC. However, the precise role of Gab2 in mediating TAM polarization remains incompletely elucidated. In the present study, it was discovered ...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Xuehan Gao Runying Long Ming Qin Wenfang Zhu Linna Wei Pinzhi Dong Jin Chen Junmin Luo Jihong Feng Source Type: research

Single ‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)
Int J Mol Med. 2024 Jan;53(1):2. doi: 10.3892/ijmm.2023.5326. Epub 2023 Nov 8.ABSTRACTOsteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration, secondary bone hyperplasia, inadequate extracellular matrix synthesis and degeneration of articular cartilage. Mesenchymal stem cells (MSCs) can self‑renew and undergo multidirectional differentiation; they can differentiate into chondrocytes. Aging MSCs have a weakened ability to differentiate, and release various pro‑inflammatory cytokines, which may contribute to OA progression; the other mechanism contributing to OA is epigenetic regu...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Dunyong Tan Zeqi Huang Zhe Zhao Xiaoqiang Chen Jianquan Liu Daping Wang Zhiqin Deng Wencui Li Source Type: research

Bone marrow mesenchymal stem cell ‑derived exosomes: A novel therapeutic agent for tendon‑bone healing (Review)
Int J Mol Med. 2023 Dec;52(6):121. doi: 10.3892/ijmm.2023.5324. Epub 2023 Nov 8.ABSTRACTIn sports medicine, injuries related to the insertion of tendons into bones, including rotator cuff injuries, anterior cruciate ligament injuries and Achilles tendon ruptures, are commonly observed. However, traditional therapies have proven to be insufficient in achieving satisfactory outcomes due to the intricate anatomical structure associated with these injuries. Adult bone marrow mesenchymal stem cells possess self‑renewal and multi‑directional differentiation potential and can generate various mesenchymal tissues to aid in the...
Source: International Journal of Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yongjia Zhu Jiapeng Yan Hongfei Zhang Guanxing Cui Source Type: research