The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study.
Abstract In various cancers, high-grade tumor and poor survival rate in patients with upregulated lncRNAs UCA1 have been confirmed. Urothelial carcinoma associated 1 (UCA1) is an oncogenic non-coding RNA with a length of more than 200 nucleotides. The UCA1 regulate critical biological processes that are involved in cancer progression, including cancer cell growth, invasion, migration, metastasis, and angiogenesis. So It should not surprise that UCA1 overexpresses in variety of cancers type, including pancreatic cancer, ovarian cancer, gastric cancer, colorectal cancer, breast cancer, prostate cancer, endometrial c...
Source: Current Molecular Medicine - June 19, 2020 Category: Molecular Biology Authors: Hosseini NF, Manoochehri H, Khoei SG, Sheykhhasan M Tags: Curr Mol Med Source Type: research

Harnessing Drug Repurposing for Exploration of New Diseases: An Insight to Strategies and Case Studies.
CONCLUSION: The data presented is proof that drug repurposing is a prolific approach circumventing the issues poised by conventional drug discovery approaches. It is a highly promising approach and when combined with sophisticated computational tools it also carries high precision. The review would help researches in prioritizing the drug-repositioning method much needed to flourish the drug discovery research. PMID: 32560606 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - June 19, 2020 Category: Molecular Biology Authors: Jain P, Jain SK, Jain M Tags: Curr Mol Med Source Type: research

Fetal Cardiac Cellular Damage Caused by Anemia in Utero in Hb Bart's Disease.
CONCLUSION: Despite equivalent prenatal cardiac function and comparable cardiac iron accumulation in the Bart's and non-anemic groups, fetal anemia is significantly associated with cardiac mitochondrial dysfunction, increased mitochondrial fission, and increased inflammation and apoptosis. These findings indicate that an early phase of fetal anemia without cardiac iron overload can lead to cardiac mitochondrial dysfunction in fetuses with Hb Bart's. PMID: 32520686 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - June 10, 2020 Category: Molecular Biology Authors: Jatavan P, Kumfu S, Tongsong T, Chattipakorn N Tags: Curr Mol Med Source Type: research

The Therapeutic Applications of Exosomes in Different Types of Diseases: A Review.
Abstract Exosomes are nano-sized vesicles secreted by nearly all cells and have received massive attention these days. In addition to their roles in pathophysiological processes and diagnostic evaluations, recently, several studies have applied exosomes to design novel therapeutic applications. Exosomes can be derived from a variety of cells and tissues and based on the source, they can carry different native contents such as DNAs, non-coding small RNAs, mRNAs, and proteins. They can also be engineered by adding desirable agents including specific biomolecules or drugs. Both forms can be therapeutically used for d...
Source: Current Molecular Medicine - June 10, 2020 Category: Molecular Biology Authors: Hosseini M, Roshangar L, Raeisi S, Ghahremanzadeh K, Negargar S, Tarmahi V, Hosseini V, Raeisi M, Rahimi E, Ebadi Z Tags: Curr Mol Med Source Type: research

Cartilage tissue and therapeutic strategies for cartilage repair.
Abstract High incidence of articular cartilage defects is still a major challenge in orthopedic and trauma surgery worldwide. It has also great socioeconomic effects as it is the major cause of disability in industrialized countries. These highlight the essential need for new treatments. Knowledge about the factors that have been implicated in the pathogenesis of cartilage diseases, including changes in the composition and structure of cartilaginous extracellular matrix (ECM), molecular factors and environmental signaling pathways could help the development of innovative therapeutic strategies. It is consensuses t...
Source: Current Molecular Medicine - June 10, 2020 Category: Molecular Biology Authors: Khajeh S, Bozorg-Ghalati F, Zare M, Panahi G, Razban V Tags: Curr Mol Med Source Type: research

Circular RNAs and Glioma: Small molecule with big actions.
Abstract Glioma is known as one of very important tumors that is associated with high rate of mortality worldwide. The mean rate of survival of these patients has not changed (approximately 14 months) even with improvements in comprehensive therapeutic approaches, such as chemotherapy, radiation, and surgery. Therefore, it seems that new therapeutic or developed platforms are needed. In this regard, more understanding about genetic and epigenetic modifications in the glioma, could contribute find and developing these platforms. Among epigenetic mechanisms, circular RNAs have crucial roles in the glioma pathogenesi...
Source: Current Molecular Medicine - June 10, 2020 Category: Molecular Biology Authors: Abi A, Ghaedi K, Khosravi A, Hayat SMG Tags: Curr Mol Med Source Type: research

The antitumor effects of icaritin against breast cancer is related to estrogen receptors.
CONCLUSION: Our study demonstrated that the antitumor effects of icaritin against breast cancer are related with ER, which suggested that the status of ER should be considered in clinical application of icaritin. PMID: 32472997 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - May 30, 2020 Category: Molecular Biology Authors: Tao CC, Wu Y, Gao X, Qiao L, Yang Y, Li F, Zou J, Wang YH, Zhang SY, Li CL, Zhang YY, Sun XD Tags: Curr Mol Med Source Type: research

Aberrant β-catenin activity in hepatoid adenocarcinoma of the stomach.
CONCLUSION: Our findings establish β-catenin as a useful marker that can distinguish HAS from CGA and may improve the early diagnosis to guide the appropriate and timely treatment of HAS patients. PMID: 32442081 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - May 22, 2020 Category: Molecular Biology Authors: Wang N, Kong R, Han W, Lu J Tags: Curr Mol Med Source Type: research

Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia.
CONCLUSION: Results of this study suggest that resveratrol is able to induce the regulation of pro-apoptotic genes and attenuate the viability of MCF-7 cells. This may indicate the sensitizing effect of resveratrol in combination with both radiotherapy and hyperthermia. PMID: 32436827 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - May 20, 2020 Category: Molecular Biology Authors: Amini P, Nodooshan SJ, Ashrafizadeh M, Eftekhari SM, Aryafar T, Khalafi L, Musa AE, Mahdavi SR, Najafi M, Farhood B Tags: Curr Mol Med Source Type: research

Metabolic ink lactate modulates epigenomic landscape: A concerted role of pro-tumor microenvironment and macroenvironment during carcinogenesis.
Abstract Tumor heterogeneity is influenced by various factors including genetic, epigenetic and axis of metabolic-epigenomic regulation. In recent, metabolic-epigenomic reprogramming is considered as one of many tumor hallmarks and it appears to be driven by both microenvironment and macroenvironment factors including diet, microbiotas and environmental pressures. Epigenetically, histone lysine residues are altered by various post-translational modifications (PTMs) such as acetylation, acylation, methylation and lactylation. Furthermore, lactylation is suggested as a new form of PTM that uses lactate substrate as ...
Source: Current Molecular Medicine - May 20, 2020 Category: Molecular Biology Authors: Sharma NK, Pal JK Tags: Curr Mol Med Source Type: research

Triazavirin - Potential inhibitor for 2019-nCoV Coronavirus M protease: A DFT study.
Abstract Triazavirin (2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4H)-one, TZV) is an antiviral drug synthesized. TZV is being investigated for potential application against the Coronavirus 2019-nCoV. In order to find candidate drugs for 2019-nCoV, we have carried out a computational study to screen for effective available drug Triazavirin (C5H4N6O3S) which may work as inhibitor for the Mpro of 2019-nCoV. In the present work, first time the molecular structure of title molecule has been investigated using Density Functional Theory (DFT/B3LYP/MidiX) in gas phase. The molecular HOMO-LUMO, excitati...
Source: Current Molecular Medicine - May 20, 2020 Category: Molecular Biology Authors: Shahab S, Sheikhi M Tags: Curr Mol Med Source Type: research

Heat shock proteins regulating Toll-like receptors and the immune system could be a novel therapeutic target for melanoma.
Abstract Melanoma is a serious type of skin cancer, which develops in melanocyte cells. Although it is less common than some other skin cancers, it can be far more dangerous if not treated at an early stage because of its ability to spread rapidly to other organs. Heat shock proteins (HSP) are intracellular molecular chaperones of naive proteins, which are induced in response to stressful conditions. HSP is released into the extracellular milieu and binds to Toll-like receptors (TLRs) to regulate immune responses, such as cytokine and chemokine release. HSPs have the capacity to release and bind to tumor-specific ...
Source: Current Molecular Medicine - May 10, 2020 Category: Molecular Biology Authors: Shomali N, Hatamnezhad LS, Tarzi S, Tamjidifar R, Xu H, Shotorbani SS Tags: Curr Mol Med Source Type: research

Diabetes-Specific Modulation of Peripheral Blood Gene Expression Signatures in Colorectal Cancer.
CONCLUSIONS: We propose that differentially expressed genes listed above might be potential biomarkers of CRC and should be studied further on larger patient groups. Diabetes might promote colorectal carcinogenesis by impairing signaling pathways in PBLs. PMID: 32364075 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - May 3, 2020 Category: Molecular Biology Authors: Molnár Z, Bánlaki Z, Somogyi A, Herold Z, Herold M, Guttman A, Rónai Z, Keszler G Tags: Curr Mol Med Source Type: research

Vaccine Plasmid Topology Monitoring by Capillary Gel Electrophoresis.
CONCLUSION: As a worked example, analysis of plasmid samples treated at elevated temperature during an accelerated stability test also demonstrated the applicability of CELIF to monitor plasmid degradation. PMID: 32338220 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 27, 2020 Category: Molecular Biology Authors: Cook KS, Luo J, Guttman A, Thompson L Tags: Curr Mol Med Source Type: research

Active Immunotherapy with 12-mer A β1-42-like Assembly Vaccine Shows Efficacy in Aged 3×Tg-AD Mice.
CONCLUSION: The novel recombinant 12×(Aβ1-15-Th) chimeric vaccine targeting of pathological conformations of Aβ oligomers has shown obvious neuroprotective benefits in preclinical AD model mouse, which indicates it is a good candidate vaccine for the prophylaxis of AD. PMID: 32338218 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 26, 2020 Category: Molecular Biology Authors: Fang H, Zhou G, Li Q, Wang H, Pang X, Xu Q, Yu Y Tags: Curr Mol Med Source Type: research

The key role of Akt protein kinase in metabolic-inflammatory pathways cross-talk: TNF- α down-regulation and improving of insulin resistance in HepG2 cell line.
CONCLUSIONS: The obtained data demonstrated that TNF-α protein expression reduction improved insulin-stimulated Akt phosphorylation in the HepG2 cells and decreased lipid-induced insulin resistance of the diabetic hepatocytes. PMID: 32338219 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 26, 2020 Category: Molecular Biology Authors: Alipourfard I, Bakhtiyari S, Gheysarzadeh A, Di Renzo L, De Lorenzo A, Mikeladze D, Khamoushi A Tags: Curr Mol Med Source Type: research

Modeling of the desialylated human serum N-glycome for molecular diagnostic applications in inflammatory and malignant lung diseases.
CONCLUSION: Our results suggested that changes in the desialylated human serum N-glycome holds glycoprotein specific molecular diagnostic potential for malignant and inflammatory lung diseases, which can be modeled with the five-protein mixture. PMID: 32321401 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 21, 2020 Category: Molecular Biology Authors: Farkas A, Mészáros B, Szarka M, Szigeti M, Kappelmayer J, Szabó M, Csánky E, Guttman A Tags: Curr Mol Med Source Type: research

Forward programming of pluripotent stem cells to neurons.
Abstract Pluripotent stem cells (PSCs) are powerful tools for studying developmental biology and neuronal diseases. Conventional differentiation protocols require several intermediate states and different culture conditions, inefficiently generating mixed subtypes of neuronal cells with immature characteristics. Direct programming of PSCs by forced expression of neuronal transcription factors has shown rapid cell fate determination with high purity as it can bypass sequential developmental steps that traditional culture requires. In this review, we focus on neuronal differentiation from PSCs to specific subtypes b...
Source: Current Molecular Medicine - April 21, 2020 Category: Molecular Biology Authors: Gu J, Cromer B, Sumer H Tags: Curr Mol Med Source Type: research

Multilevel characterization of antibody-ligand conjugates by CESI-MS.
CONCLUSION: The developed multilevel analytical method offers a comprehensive way to determine the localization and stoichiometry of antibody-drug conjugates for molecular medicinal applications. In addition, a significant advantage of the reported approach is that small, hydrophilic, unmodified peptides well separated from the neutrals, which is not common with other liquid phase separation methods such as LC. PMID: 32294034 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 14, 2020 Category: Molecular Biology Authors: Fonslow B, Jarvas G, Szigeti M, Guttman A Tags: Curr Mol Med Source Type: research

N-glycomic analysis of Z(IgA1) partitioned serum and salivary immunoglobulin A by capillary electrophoresis..
Abstract AIMS: To apply capillary electrophoresis with laser induced fluorescence detection (CE-LIF) to identify the N-glycosylation structures of serum and saliva IgA from healthy controls and patients with malignant hematological diseases having cytostatic treatment induced mild oral mucosal lesions. BACKGROUND: Altered N-glycosylation of body fluid glycoproteins can be effective indicators of most inflammatory processes. Immunoglobulin A (IgA) is the second highest abundant of the immunoglobulins and has a major role in the immune-defense against potential pathogen attacks. While IgA is abundant in serum, ...
Source: Current Molecular Medicine - April 13, 2020 Category: Molecular Biology Authors: Meszaros B, Kovacs Z, Gebri E, Jankovics H, Vonderviszt F, Kiss A, Simon A, Botka S, Hortobagyi T, Guttman A Tags: Curr Mol Med Source Type: research

Cholesterol: A prelate in cell nucleus and its serendipity. .
Abstract Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making steroid endocrines, acting as precursors of metabolic regulators and many more with its emerging prophecy in cell nucleus to drive new cell formation. Besides the crucial legacy in cellular functionality, cholesterol is ostracized as a member of LDL particle which has been proved responsible ...
Source: Current Molecular Medicine - April 13, 2020 Category: Molecular Biology Authors: Saxena N, Chandra NC Tags: Curr Mol Med Source Type: research

Association of High-Mobility Group Box-1 with Inflammation-Related Cytokines in the Aqueous Humor with Acute Primary Angle-Closure eyes.
CONCLUSIONS: The aqueous level of HMGB1 is elevated in APAG and is associated with aqueous level of inflammation-related cytokines, suggesting an association between elevated levels of HMGB1, APAC and certain inflammatory modulators which, of course, should lead to further investigations in order to demonstrate cause and effect. PMID: 32282301 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 13, 2020 Category: Molecular Biology Authors: He W, Xu F, Chen L, Huang W, Jiang L, Tang F, Yan W, Zhong S, Shen C, Huang H, Lv J, Wu X, Zeng S, Li M, Zhang M Tags: Curr Mol Med Source Type: research

Nifurtimox hampered the progression of astroglioma in vivo via manipulating the AKT-GSK3 βaxis.
Nifurtimox hampered the progression of astroglioma in vivo via manipulating the AKT-GSK3βaxis. Curr Mol Med. 2020 Apr 09;: Authors: Zhang Q, Chen Z, Yuan W, Tang YQ, Zhu J, Wu W, Ren H, Wang H, Zheng W, Zhang Z, Kong E Abstract Astroglioma, one major form of brain tumors, has remained principally tough to handle for decades, due to the complexity of tumor pathology and the poor response to chemo- and radio-therapies. Our previous study demonstrated that nifurtimox could regulate the signaling axis of AKT-GSK3β in vari ous tumor types including the astroglioma U251 cells. Intriguingly, earlie...
Source: Current Molecular Medicine - April 9, 2020 Category: Molecular Biology Authors: Zhang Q, Chen Z, Yuan W, Tang YQ, Zhu J, Wu W, Ren H, Wang H, Zheng W, Zhang Z, Kong E Tags: Curr Mol Med Source Type: research

Increased heat shock protein expression decreases inflammation in skeletal muscle during and after frostbite injury.
CONCLUSION: We conclude that compounds such as 17-DMAG that induce the heat shock proteins are able to preserve skeletal muscle function and structure if injected within 30 minutes after frostbite injury. Our studies provide the basis for the development of a potential therapeutic strategy to treat injury caused by frostbite. PMID: 32264811 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - April 6, 2020 Category: Molecular Biology Authors: Liskutin T, Batey J, Li R, Schweigert C, Mestril R Tags: Curr Mol Med Source Type: research

A Study On The Correlation Between Slit2/Robo1 Signaling Pathway Proteins And Polymyositis/Dermatomyositis.
This study attempted to explore the specific mechanism of Slit2/Robo1 signaling pathway proteins during the vascular disease of PM/DM. METHODS: The mRNA expressions of Slit2 and Robo1 in the muscle tissue were detected by RT-qPCR between newly-diagnosed PM/DM patients and healthy controls. The number of Slit2 and Robo1 positive cells in the serial sections of muscle paraffin tissues was measured by immunohistochemistry in 10 patients with PM, 10 patients with DM and 20 healthy controls. RESULTS: The study results revealed that the mRNA expressions of Slit2 and Robo1 in muscle tissue in the PM and DM groups were h...
Source: Current Molecular Medicine - March 25, 2020 Category: Molecular Biology Authors: Chai KX, Chen YQ, Kong LS, Fan PL, Yuan X, Yang J Tags: Curr Mol Med Source Type: research

Hyaluronic acid and Regenerative medicine: New insights into the stroke therapy.
Abstract Stroke is known as one of very important public health problems which are related to a societal burden and tremendous economic. It has been showed, there are few therapeutic approaches in the treatment of this disease. In this regard, present therapeutic platforms aim to obtain neuroprotection, reperfusion, and neurorecovery. Among these therapies, regenerative medicine-based therapies have been appeared as new ways in stroke therapy. Hyaluronic acid (HA) is a new candidate which could be applied as regerenative medicine-based therapy in the treatment of stroke. HA is a glycosaminoglycan which is formed o...
Source: Current Molecular Medicine - March 25, 2020 Category: Molecular Biology Authors: Shahi M, Mohammadnejad D, Karimipour M, Rasta SH, Rahbarghazi R, Elahi AA Tags: Curr Mol Med Source Type: research

The Antihypertensive, Antimicrobial and Anticancer peptides from Arthrospira with therapeutic potential: A minireview.
Abstract The interest in biological peptides from Arthrospira sp. (syn Spirulina) is increasing due to its GRAS status, the high concentration of proteins and the history of its use as a supplement and nutraceutical agent. Arthrospira peptides can be generated by controlled hydrolysis of the proteins, using proteases, followed by fractionation. The peptides obtained have a range of therapeutic effects. Amongst these bioactive peptides, three classes are of major importance: the antihypertensive (AHP), antimicrobial (AMP) and anticancer (ACP) peptides. AHPs have the ability to work as inhibitors of ACE, the angiote...
Source: Current Molecular Medicine - March 19, 2020 Category: Molecular Biology Authors: Montalvo G, Vandenberghe L, Soccol V, Carvalho J, Soccol C Tags: Curr Mol Med Source Type: research

Uterine Dnmt3a is not required for mouse embryo implantation.
CONCLUSION: Overall, these results demonstrated that although some decidual markers are expressed abnormally, conditional knockout of Dnmt3a in the uterus did not significantly affect the endometrial function during embryo implantation; the embryo could implant into the endometrium normally. PMID: 32096741 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 24, 2020 Category: Molecular Biology Authors: Li N, Lu S, Ding Y, Chen X, He J, Liu X, Chen M, Zhang J, Su Y, Zhang X, Wang Y, Gao R Tags: Curr Mol Med Source Type: research

An in vivo immunohistochemical study on MacroH2A.1 in lung and lymph-node tissues exposed to an asbestiform fiber.
CONCLUSION: In this contest, MacroH2A.1 overexpression supports its function as an epigenetic stabilizer that helps to establish and maintain differentiated states. PMID: 32077824 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 20, 2020 Category: Molecular Biology Authors: Loreto C, Lombardo C, Caltabiano R, Ledda C, Hagnas M, Filetti V, Rapisarda V Tags: Curr Mol Med Source Type: research

Effects of carvedilol on expression of TLR4 and its downstream signaling pathway in liver tissue of rats with cholestatic liver fibrosis.
CONCLUSIONS: Carvedilol can reduce the release of inflammatory mediators by down-regulating TLR4 expression and inhibiting its downstream signaling pathway, thus playing a potential therapeutic role in cholestatic liver fibrosis. PMID: 32077825 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 20, 2020 Category: Molecular Biology Authors: Tian X, Zhao H, Guo Z Tags: Curr Mol Med Source Type: research

High Plasmatic Levels of Advanced Glycation End Products are Associated with Metabolic Alterations and Insulin Resistance in Preeclamptic Women.
CONCLUSIONS: Circulating levels of AGEs were higher in patients with preeclampsia than those observed in healthy pregnant subjects. Besides, hepatic and metabolic profiles, particularly those related to insulin resistance, were higher in preeclampsia as compared with healthy pregnant subjects. Interestingly, there is a positive correlation between AGEs levels and insulin resistance, suggesting that excessive glycation and an impaired metabolic profile contribute to the physiopathology of preeclampsia. PMID: 32077826 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 20, 2020 Category: Molecular Biology Authors: García-Gómez E, Bobadilla-Bravo M, Díaz-Díaz E, Vázquez-Martínez ER, Nava-Salazar S, Torres-Ramos Y, García-Romero CS, Camacho-Arroyo I, Cerbón M Tags: Curr Mol Med Source Type: research

Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 cells in Vitro: Synergistic Effect with β-caryophyllene.
CONCLUSION: Metaxalone was found to suppress the activity of inflammatory macrophages in vitro. PMID: 32065089 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 16, 2020 Category: Molecular Biology Authors: Yamaguchi M, Levy RM Tags: Curr Mol Med Source Type: research

3-methyladenine inhibits procollagen-1 and fibronectin expression in dermal fibroblasts independent of autophagy.
CONCLUSION: We revealed that 3-MA might inhibit procollagen-1 and fibronectin synthesis in an autophagy-independent manner by interfering with the binding between Smad3 and p300. Therefore, 3-MA could be a candidate for the treatment of diseases associated with the accumulation of ECM proteins. PMID: 32031067 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - February 7, 2020 Category: Molecular Biology Authors: Jung JY, Choi H, Son ED, Kim HJ Tags: Curr Mol Med Source Type: research

An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance.
Abstract Malaria is one of the three most deadly infectious diseases in the world and seriously endangers human health and life. To reduce the public health burden of this disease, scientists have focused on the discovery and development of effective antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its derivatives, which all play a profound role in the treatment of malaria. However, drug-resistant strains of Plasmodium falciparum have emerged due to frequent use of antimalarials and have become increasingly resistant to existing antimalarial drugs , which had caused disastrous co...
Source: Current Molecular Medicine - February 7, 2020 Category: Molecular Biology Authors: Tang YQ, Ye Q, Huang H, Zheng WY Tags: Curr Mol Med Source Type: research

Understanding mass spectrometry based global mycobacterial lipidomics.
Abstract Tuberculosis (TB) is the foremost cause of mortality from single infectious agent Mycobacterium tuberculosis (MTB). Current therapeutic regimes suffer from several problems including side effects, costs and emergence of multidrug resistance (MDR). Moreover, conventional diagnostic methods are either too slow, lack accurate or robust biomarkers. Under such circumstances, identification of rapid metabolite based biomarkers as novel drug targets could be a potential approach to circumvent MDR. In the era of "OMIC" sciences, lipidomics has gain significant attention to unravel the complexity of lipi...
Source: Current Molecular Medicine - February 6, 2020 Category: Molecular Biology Authors: Fatima Z, Nandan S, Hameed S Tags: Curr Mol Med Source Type: research

Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic role.
In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles. PMID: 31995005 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 29, 2020 Category: Molecular Biology Authors: Abbaszadeh-Goudarzi K, Radbakhsh S, Pourhanifeh MH, Khanbabaei H, Davoodvandi A, Fathizadeh H, Sahebkar A, Shahrzad MK, Mirzaei H Tags: Curr Mol Med Source Type: research

A Brief Overview of the Oral Delivery of Insulin as an Alternative to the Parenteral Delivery.
L, Fonte P Abstract Diabetes mellitus greatly affects the quality of life of patients and has a worldwide prevalence. Insulin is the most commonly used drug to treat diabetic patients and is usually administered through the subcutaneous route. However, this route of administration is ineffective due to the low concentration of insulin at the site of action. This route of administration causes discomfort to the patient and increases the risk of infection due to skin barrier disturbance caused by the needle. The oral administration of insulin has been proposed to surpass the disadvantages of subcutaneous administra...
Source: Current Molecular Medicine - January 25, 2020 Category: Molecular Biology Authors: Macedo A, Filipe P, Thomé NG, Vieira J, Oliveira C, Teodósio C, Ferreira R, Roque L, Fonte P Tags: Curr Mol Med Source Type: research

Ursodeoxycholic acid (UDCA) promotes lactate metabolism in mouse hepatocytes through cholic acid (CA) - farnesoid X receptor (FXR) pathway.
CONCLUSIONS: These results demonstrate that UDCA promotes lactate metabolism in mouse hepatocytes through CA-FXR pathway. PMID: 31971110 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 23, 2020 Category: Molecular Biology Authors: Wang L, He HW, Zhou X, Long Y Tags: Curr Mol Med Source Type: research

Hepatocyte growth factor secreted from human adipose-derived stem cells inhibits fibrosis in hypertrophic scar fibroblasts.
CONCLUSION: Our findings revealed that adipose-derived stem cell-secreted HGF effectively inhibits fibrosis-related factors and regulates extracellular matrix (ECM) remodeling in hypertrophic scar fibroblasts. PMID: 31903876 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2020 Category: Molecular Biology Authors: Ma J, Yan X, Lin Y, Tan Q Tags: Curr Mol Med Source Type: research

Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation.
CONCLUSION: HCA inhibits renal injury and calcium oxalate crystal deposition in the glyoxylate-induced mouse model through antioxidation and anti-inflammation. PMID: 31902360 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 3, 2020 Category: Molecular Biology Authors: Liu X, Yuan P, Sun X, Chen Z Tags: Curr Mol Med Source Type: research

MiR-143HG gene polymorphisms as risk factors for gastric cancer in Chinese Han population.
CONCLUSION: For the first time, our results provide some evidence on polymorphisms of miR-143HG associated with GC risk in the Chinese Han population. PMID: 31880258 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 26, 2019 Category: Molecular Biology Authors: Liu J, Li H, Liu Y, Sun Y, Wu J, Xiong Z, Jin T, Li B Tags: Curr Mol Med Source Type: research

FBXW7alpha promotes the recovery of traumatic spinal cord.
CONCLUSION: Our data indicate FBXW7αprobably servers as an important molecular target for the therapy of spinal cord injury. PMID: 31870261 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 23, 2019 Category: Molecular Biology Authors: Zhang H, Yang T Tags: Curr Mol Med Source Type: research

Preface.
PMID: 31858901 [PubMed - in process] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 21, 2019 Category: Molecular Biology Authors: Guttman A Tags: Curr Mol Med Source Type: research

Depression as is seen by molecular spectroscopy. Phospholipid-protein balance in affective disorders and dementia.
Abstract There is an expanding field of research investigating the instrumental methods to measure development of affective disorders. The goal of the commentary is to turn attention of medical practitioners at the molecular spectroscopy techniques (FTIR, Raman and UV-Vis) that can be applied for monitoring and quantification of the phospholipid-protein balance in human blood serum of depressed patients. Even facial overview of cited original research strongly suggest that disturbed phospholipid-protein balance could be one of the biomarkers of affective disorders. The blood serum monitoring of depressed patients ...
Source: Current Molecular Medicine - December 18, 2019 Category: Molecular Biology Authors: Pogocki D, Kisała J, Cebulski J Tags: Curr Mol Med Source Type: research

Single cell analysis of β2-Adrenergic receptor dynamics by quantitative fluorescence Microscopy.
CONCLUSION: We describe a highly accurate method of measuring β2-AR surface and total expression based on single cell quantitative immunofluorescence. The method can be used to determine agonist induced desensitization and resensitization process as well receptor kinetics like endocytosis and exocytosis of β2-Adrenergic receptor and can be applied to essentially any other GPCR. PMID: 31840614 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 16, 2019 Category: Molecular Biology Authors: Haji E, Mahri SA, Aloraij Y, Malik S, Mohammad S Tags: Curr Mol Med Source Type: research

miRNAs Signatures In Patients With Acute Liver Injury: Clinical Concerns and Correlations.
Abstract Non-coding RNAs can be highly exploited for their biological significance in living systems. miRNAs are in upstream position of cellular regulation cascade and holds merit in its state. A wealth of information is available on wide variety of miRNAs that undergo alterations in experimentally induced models of liver injuries. The underlying mechanisms governed by these miRNAs have been inferred through cell-based experiments but the scientific knowledge on miRNA signatures in patients with liver injury are primordial and lack scientific clarity. Hence, it is crucial to get insight into the status and synerg...
Source: Current Molecular Medicine - December 11, 2019 Category: Molecular Biology Authors: Vyas HS, Upadhyay KK, Devkar RV Tags: Curr Mol Med Source Type: research

Association between Single-nucleotide Polymorphisms of RXRG and Genetic Susceptibility to Type 2 Diabetes in South China.
CONCLUSION: Our Results Showed That The Single Nucleotide Polymorphism Of Rxrg Rs3753898 May Be Related To The Genetic Susceptibility Of Type 2 Diabetes. The Haplotype Consisting Of The Allele T Of Rs1467664 And The Allele A Of Rs3753898 Is A Risk Factor For Type 2 Diabetes, Suggesting That Genetic Variation Of Rxrg Gene May Be The Genetic Cause Of Diabetes Mellitus In Chinese Han Population. PMID: 31808386 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 6, 2019 Category: Molecular Biology Authors: Yu H, Wang S, Hu W, Xu L, Ding Y, Kong D, Pan H Tags: Curr Mol Med Source Type: research

Natural products with analgesic effect from herbs and nutraceuticals used in Traditional Chinese Medicines.
Abstract INTRODUCTION: Pain is one of the most common symptoms in clinical. This review is to describe researches on herbs and their active ingredients in treating pain and provide valuable reference for the development and utilization of analgesic traditional Chinese medicine (TCM). Areas covered: The literature search was performed from 1995 to October 2016, covering the relevant literatures that concern the treatment of pain with TCM. Active ingredients extracted from TCM with analgesic activity are summarized and classified into six categories, including polysaccharides, saponins, alkaloids, flavonoids, terpen...
Source: Current Molecular Medicine - December 4, 2019 Category: Molecular Biology Authors: Wang TX, Jiang JG Tags: Curr Mol Med Source Type: research

RPS24c isoform facilitates tumor angiogenesis via promoting the stability of MVIH in colorectal cancer.
CONCLUSION: RPS24c facilitates tumor angiogenesis via the RPS24c/MVIH/PGK1 pathway in CRC. RPS24c inhibition may be a novel option for anti-vascular treatment in CRC. PMID: 31797757 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - December 3, 2019 Category: Molecular Biology Authors: Wang Y, Wu Y, Xiao K, Zhao Y, Lv G, Xu S, Wu F Tags: Curr Mol Med Source Type: research

Convolutional neural network visualization for identification of risk genes in bipolar disorder.
Abstract BACKGROUND: Bipolar disorder (BD) is a type of chronic emotional disorder with a complex genetic structure. However, its genetic molecular mechanism is still unclear, which makes it insufficiently to be diagnosed and treated. METHODS AND RESULTS: In this paper, we proposed a model for predicting BD based on single nucleotide polymorphisms (SNPs) screening by genome-wide association study (GWAS), which was constructed by a convolutional neural network (CNN) that predicted the probability of the disease. According to the difference of GWAS threshold, two sets of data were named: group P001 and group P0...
Source: Current Molecular Medicine - November 28, 2019 Category: Molecular Biology Authors: Yue Q, Yang J, Shu Q, Bai M, Shu K Tags: Curr Mol Med Source Type: research