The Expression and Molecular Mechanisms of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.PMID:37936436 | DOI:10.2174/0115665240264823231101103226 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Shujun Lin Wenshan Lin Zhiqing Zhong Hongzhen Zhong Tianbiao Zhou Wenjuan Weng Source Type: research
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
CONCLUSION: Our study identified SCIN as an upregulated gene in ARC, which is negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate OS-induced apoptosis in LECs.PMID:37936437 | DOI:10.2174/0115665240250050231030110542 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yan Li Li Tang Guanxing Dang Mengyuan Ma Xingfang Tang Source Type: research
The Expression and Molecular Mechanisms of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.PMID:37936436 | DOI:10.2174/0115665240264823231101103226 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Shujun Lin Wenshan Lin Zhiqing Zhong Hongzhen Zhong Tianbiao Zhou Wenjuan Weng Source Type: research
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
CONCLUSION: Our study identified SCIN as an upregulated gene in ARC, which is negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate OS-induced apoptosis in LECs.PMID:37936437 | DOI:10.2174/0115665240250050231030110542 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yan Li Li Tang Guanxing Dang Mengyuan Ma Xingfang Tang Source Type: research
The Expression and Molecular Mechanisms of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.PMID:37936436 | DOI:10.2174/0115665240264823231101103226 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Shujun Lin Wenshan Lin Zhiqing Zhong Hongzhen Zhong Tianbiao Zhou Wenjuan Weng Source Type: research
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
CONCLUSION: Our study identified SCIN as an upregulated gene in ARC, which is negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate OS-induced apoptosis in LECs.PMID:37936437 | DOI:10.2174/0115665240250050231030110542 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yan Li Li Tang Guanxing Dang Mengyuan Ma Xingfang Tang Source Type: research
The Expression and Molecular Mechanisms of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.PMID:37936436 | DOI:10.2174/0115665240264823231101103226 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Shujun Lin Wenshan Lin Zhiqing Zhong Hongzhen Zhong Tianbiao Zhou Wenjuan Weng Source Type: research
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
CONCLUSION: Our study identified SCIN as an upregulated gene in ARC, which is negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate OS-induced apoptosis in LECs.PMID:37936437 | DOI:10.2174/0115665240250050231030110542 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yan Li Li Tang Guanxing Dang Mengyuan Ma Xingfang Tang Source Type: research
The Expression and Molecular Mechanisms of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats
In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.PMID:37936436 | DOI:10.2174/0115665240264823231101103226 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Shujun Lin Wenshan Lin Zhiqing Zhong Hongzhen Zhong Tianbiao Zhou Wenjuan Weng Source Type: research
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
CONCLUSION: Our study identified SCIN as an upregulated gene in ARC, which is negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate OS-induced apoptosis in LECs.PMID:37936437 | DOI:10.2174/0115665240250050231030110542 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 8, 2023 Category: Molecular Biology Authors: Yan Li Li Tang Guanxing Dang Mengyuan Ma Xingfang Tang Source Type: research
Therapeutic Effects of Berberine against Urological Cancers: Biological Potentials Based on Cellular Mechanisms
Curr Mol Med. 2023 Nov 6. doi: 10.2174/0115665240263630231009050436. Online ahead of print.ABSTRACTUrological cancers, including prostate, kidney, and bladder cancer are problematic human diseases worldwide. Current strategies for the treatment of these cancers are chemotherapy, radiotherapy, surgery, or a combination of mentioned therapies. Due to the high mortality and morbidity rate of urological cancers and possible side effects of available standard treatments, searching for more effective and safe treatments is a critical issue. The beneficial properties of natural compounds, such as berberine, have been widely inves...
Source: Current Molecular Medicine - November 7, 2023 Category: Molecular Biology Authors: Ali Bozorg Savoji Yasamin Kaheni Pouria Rezaei Tahereh Farkhondeh Mohammad Hossein Pourhanifeh Saeed Samarghandian Source Type: research
Tanshinone Alleviates UVA-induced Melanogenesis in Melanocytes via the Nrf2-regulated Antioxidant Defense Signaling Pathway
CONCLUSION: These results suggest that T-I and DHT inhibit UVA-induced melanogenesis in HEM cells, possibly through redox mechanisms involving Nrf2 signaling activation and increased antioxidant defenses. This indicates that T-I and DHT have potential as whitening agents in cosmetics and medical treatments for hyperpigmentation disorders.PMID:37921187 | DOI:10.2174/0115665240263196230920161019 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 3, 2023 Category: Molecular Biology Authors: Jiaoquan Chen Zonghao Yin Nanji Yu Shanshan Ou Xue Wang Huaping Li Huilan Zhu Source Type: research
HMGB1/RAGE Signaling Regulates Th17/IL-17 and Its Role in Bronchial Epithelial-Mesenchymal Transformation
CONCLUSION: HMGB1/RAGE signaling synergistically enhanced TGF-β1-induced bronchial EMT by promoting the differentiation of Th17 cells and the secretion of IL-17.PMID:37921188 | DOI:10.2174/0115665240249953231024060610 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 3, 2023 Category: Molecular Biology Authors: Jingyi Sun Yan Jiang Linqiao Li Rou Li Feixiang Ling Xiaojing Du Qian Han Shuyuan Chu Yaxi Liang Lin Mai Libing Ma Source Type: research
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/ β-catenin
CONCLUSION: The findings suggest that inhibiting USP3 is an effective strategy against cancer stem cells and chemo-resistant HCC cells.PMID:37921189 | DOI:10.2174/0115665240258296231024112309 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 3, 2023 Category: Molecular Biology Authors: Jianguo Xu Ge Sang Wang Gui Chao Yang Shuchen Zhu Zemin Chen Suo Lang Bai Ma Ci Yang Ci Ren Luo Bu Ying Zhu Wen Xu Source Type: research
Tanshinone Alleviates UVA-induced Melanogenesis in Melanocytes via the Nrf2-regulated Antioxidant Defense Signaling Pathway
CONCLUSION: These results suggest that T-I and DHT inhibit UVA-induced melanogenesis in HEM cells, possibly through redox mechanisms involving Nrf2 signaling activation and increased antioxidant defenses. This indicates that T-I and DHT have potential as whitening agents in cosmetics and medical treatments for hyperpigmentation disorders.PMID:37921187 | DOI:10.2174/0115665240263196230920161019 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - November 3, 2023 Category: Molecular Biology Authors: Jiaoquan Chen Zonghao Yin Nanji Yu Shanshan Ou Xue Wang Huaping Li Huilan Zhu Source Type: research
