Functional Insight into hTRIR
Curr Mol Med. 2023 Oct 20. doi: 10.2174/0115665240260310231016112946. Online ahead of print.ABSTRACTThe uncharacterized C19orf43 was discovered to be associated with hTR maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61). hTRIR works in a broad range of temperatures and pH without any divalent cations needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In addition, hTRIR digested both ends of methylated small RNA, which suggested that it was a putative ribonuclease. Later, we designe...
Source: Current Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Jumin Xie Hui Mao Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Astragaloside IV Protects Against IL-1 β-Induced Chondrocyte Damage via Activating Autophagy
CONCLUSION: Our findings suggest that AS-IV mitigates inflammatory chondrocyte injury, safeguarding chondrocytes through a potential autophagy suppression mechanism. These results imply that AS-IV could offer preventive advantages for OA.PMID:37855351 | DOI:10.2174/0115665240249154231016080115 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 19, 2023 Category: Molecular Biology Authors: Hang Xu Jing-Bo Wang Yue-Ping Chen Wei Huang Zong-Bo We Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC
CONCLUSION: CSF, serum and urine metabolomic analyses could differentiate TBI DOC from NTBI DOC and functional analyses showed a metabolic change difference between TBI DOC and NTBI DOC.PMID:37817528 | DOI:10.2174/0115665240249826230928104512 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Xiaoping Xiao Long Xu Hezhen Lu Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Qianqian Ge Yutong Zhuang Xiaoli Geng Xueling Chen Ying Lan Jianghong He Wei Sun Source Type: research
The Role of Tissue Factor In Signaling Pathways of Pathological Conditions and Angiogenesis
In this study, we have reviewed the TF signaling pathways in different pathological conditions, such as wound injury, asthma, cardiovascular diseases (CVDs), viral infections, cancer and pathological angiogenesis. Angiogenic activities of TF are critical in the repair of wound injuries and aggressive behavior of tumors, which are mainly performed by the actions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF1-α). Pro-inflammatory effects of TF have been reported in asthma, CVDs and viral infections, including COVID-19, which result in tissue hypertrophy, inflammation, and thrombosis. TF-FV...
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Zahra Heidari Yasaman Naeimzadeh Jafar Fallahi Amir Savardashtaki Vahid Razban Sahar Khajeh ا Source Type: research
Deciphering Molecular Mechanisms of Carbon TetrachlorideInduced Hepatotoxicity (Fibrosis): A Brief Systematic Review
Curr Mol Med. 2023 Oct 5. doi: 10.2174/0115665240257603230919103539. Online ahead of print.ABSTRACTThe liver plays a critical role in metabolic processes, making it vulnerable to injury. Researchers often study carbon tetrachloride (CCl4)-induced hepatotoxicity in model organisms because it closely resembles human liver damage. This toxicity occurs due to the activation of various cytochromes, including CYP2E1, CYP2B1, CYP2B2, and possibly CYP3A, which produce the trichloromethyl radical (CCl3*). CCl3* can attach to biological molecules such as lipids, proteins, and nucleic acids, impairing lipid metabolism and leading to ...
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Muhammad Mazhar Fareed Hina Khalid Sana Khalid Sergey Shityakov Source Type: research
Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC
CONCLUSION: CSF, serum and urine metabolomic analyses could differentiate TBI DOC from NTBI DOC and functional analyses showed a metabolic change difference between TBI DOC and NTBI DOC.PMID:37817528 | DOI:10.2174/0115665240249826230928104512 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Xiaoping Xiao Long Xu Hezhen Lu Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Qianqian Ge Yutong Zhuang Xiaoli Geng Xueling Chen Ying Lan Jianghong He Wei Sun Source Type: research
The Role of Tissue Factor In Signaling Pathways of Pathological Conditions and Angiogenesis
In this study, we have reviewed the TF signaling pathways in different pathological conditions, such as wound injury, asthma, cardiovascular diseases (CVDs), viral infections, cancer and pathological angiogenesis. Angiogenic activities of TF are critical in the repair of wound injuries and aggressive behavior of tumors, which are mainly performed by the actions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF1-α). Pro-inflammatory effects of TF have been reported in asthma, CVDs and viral infections, including COVID-19, which result in tissue hypertrophy, inflammation, and thrombosis. TF-FV...
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Zahra Heidari Yasaman Naeimzadeh Jafar Fallahi Amir Savardashtaki Vahid Razban Sahar Khajeh ا Source Type: research
Deciphering Molecular Mechanisms of Carbon TetrachlorideInduced Hepatotoxicity (Fibrosis): A Brief Systematic Review
Curr Mol Med. 2023 Oct 5. doi: 10.2174/0115665240257603230919103539. Online ahead of print.ABSTRACTThe liver plays a critical role in metabolic processes, making it vulnerable to injury. Researchers often study carbon tetrachloride (CCl4)-induced hepatotoxicity in model organisms because it closely resembles human liver damage. This toxicity occurs due to the activation of various cytochromes, including CYP2E1, CYP2B1, CYP2B2, and possibly CYP3A, which produce the trichloromethyl radical (CCl3*). CCl3* can attach to biological molecules such as lipids, proteins, and nucleic acids, impairing lipid metabolism and leading to ...
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Muhammad Mazhar Fareed Hina Khalid Sana Khalid Sergey Shityakov Source Type: research
