Glutathione Therapy in Diseases: Challenges and Potential Solutions for Therapeutic Advancement
Curr Mol Med. 2023 Aug 18. doi: 10.2174/1566524023666230818142831. Online ahead of print.ABSTRACTAn endogenous antioxidant, reduced glutathione (GSH), is found at high concentrations in nearly all typical cells. GSH synthesis is a controlled process, and any disruption in the process of GSH synthesis could result in GSH depletion. Cellular oxidative damage results from GSH depletion. Various pathological conditions such as aging, cardiovascular disease (CVD), psychiatric disorders, neurological disorders, liver disorders, and diabetes mellitus are more affected by this stress. There are various reasons for GSH reduction, b...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Hossein Tahmasebi Dehkordi Sorayya Ghasemi Source Type: research
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives
In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.PMID:37594115 | DOI:10.2174/1566524023666230818093016 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Rezvan Mohammadi Sepideh Ghani Roghaye Arezumand Shohreh Farhadi Yalda Khazaee-Poul Bahram Kazemi Fatemeh Yarian Somaye Noruzi Abbas Alibakhshi Mahsa Jalili Shahin Aghamiri Source Type: research
Resveratrol: Targeting cancer stem cells and ncRNAs to overcome cancer drug resistance
Curr Mol Med. 2023 Aug 17. doi: 10.2174/1566524023666230817102114. Online ahead of print.ABSTRACTA major challenge in treating cancer is the development of drug resistance, which can result in treatment failure and tumor recurrence. Targeting cancer stem cells (CSCs) and non-coding RNAs (ncRNAs) with a polyphenolic substance called resveratrol has the ability to combat this problem by lowering cancer resistance to drugs and opening up new therapeutic options. Resveratrol alters the expression of genes related to self-renewal, modulating important signaling pathways involved in cancer initiation and CSC control. Additionall...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Leila Rezakhani Sima Salmani Masoumeh Eliyasi Dashtaki Sorayya Ghasemi Source Type: research
Hydroquinidine demonstrates remarkable antineoplastic effects on non-small cell lung cancer cells
CONCLUSION: Our findings suggest that HQ has the potential to limit lung cancer growth as a novel potent anticarcinogenic agent. However, more investigations are needed to gain further insight into the mechanism of action of HQ and to evaluate its efficacy in in-vivo models.PMID:37592773 | DOI:10.2174/1566524023666230817115937 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Mervenur Yavuz Turan Demircan Source Type: research
Glutathione Therapy in Diseases: Challenges and Potential Solutions for Therapeutic Advancement
Curr Mol Med. 2023 Aug 18. doi: 10.2174/1566524023666230818142831. Online ahead of print.ABSTRACTAn endogenous antioxidant, reduced glutathione (GSH), is found at high concentrations in nearly all typical cells. GSH synthesis is a controlled process, and any disruption in the process of GSH synthesis could result in GSH depletion. Cellular oxidative damage results from GSH depletion. Various pathological conditions such as aging, cardiovascular disease (CVD), psychiatric disorders, neurological disorders, liver disorders, and diabetes mellitus are more affected by this stress. There are various reasons for GSH reduction, b...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Hossein Tahmasebi Dehkordi Sorayya Ghasemi Source Type: research
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives
In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.PMID:37594115 | DOI:10.2174/1566524023666230818093016 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Rezvan Mohammadi Sepideh Ghani Roghaye Arezumand Shohreh Farhadi Yalda Khazaee-Poul Bahram Kazemi Fatemeh Yarian Somaye Noruzi Abbas Alibakhshi Mahsa Jalili Shahin Aghamiri Source Type: research
Resveratrol: Targeting cancer stem cells and ncRNAs to overcome cancer drug resistance
Curr Mol Med. 2023 Aug 17. doi: 10.2174/1566524023666230817102114. Online ahead of print.ABSTRACTA major challenge in treating cancer is the development of drug resistance, which can result in treatment failure and tumor recurrence. Targeting cancer stem cells (CSCs) and non-coding RNAs (ncRNAs) with a polyphenolic substance called resveratrol has the ability to combat this problem by lowering cancer resistance to drugs and opening up new therapeutic options. Resveratrol alters the expression of genes related to self-renewal, modulating important signaling pathways involved in cancer initiation and CSC control. Additionall...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Leila Rezakhani Sima Salmani Masoumeh Eliyasi Dashtaki Sorayya Ghasemi Source Type: research
Hydroquinidine demonstrates remarkable antineoplastic effects on non-small cell lung cancer cells
CONCLUSION: Our findings suggest that HQ has the potential to limit lung cancer growth as a novel potent anticarcinogenic agent. However, more investigations are needed to gain further insight into the mechanism of action of HQ and to evaluate its efficacy in in-vivo models.PMID:37592773 | DOI:10.2174/1566524023666230817115937 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Mervenur Yavuz Turan Demircan Source Type: research
Glutathione Therapy in Diseases: Challenges and Potential Solutions for Therapeutic Advancement
Curr Mol Med. 2023 Aug 18. doi: 10.2174/1566524023666230818142831. Online ahead of print.ABSTRACTAn endogenous antioxidant, reduced glutathione (GSH), is found at high concentrations in nearly all typical cells. GSH synthesis is a controlled process, and any disruption in the process of GSH synthesis could result in GSH depletion. Cellular oxidative damage results from GSH depletion. Various pathological conditions such as aging, cardiovascular disease (CVD), psychiatric disorders, neurological disorders, liver disorders, and diabetes mellitus are more affected by this stress. There are various reasons for GSH reduction, b...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Hossein Tahmasebi Dehkordi Sorayya Ghasemi Source Type: research
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives
In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.PMID:37594115 | DOI:10.2174/1566524023666230818093016 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Rezvan Mohammadi Sepideh Ghani Roghaye Arezumand Shohreh Farhadi Yalda Khazaee-Poul Bahram Kazemi Fatemeh Yarian Somaye Noruzi Abbas Alibakhshi Mahsa Jalili Shahin Aghamiri Source Type: research
Exosomes derived from Mouse Bone Marrow Mesenchymal Stem Cells Attenuate Nucleus Pulposus Cell Apoptosis via the miR-155- 5p/Trim32 Axis
CONCLUSION: Overall, these findings suggest that exosomes from BMSCs can suppress TNF-α-induced cell cycle arrest and apoptosis in primary mouse NPCs through the delivery of miR-155-5p by targeting Trim32. This study provides a promising therapeutic strategy for IVDD.PMID:37587825 | DOI:10.2174/1566524023666230816090843 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Fei Chen Shangze Li Ji Wu Qunfeng Guo Haibin Wang Bin Ni Jun Yang Source Type: research
The emerging role of LncRNA AWPPH in multiple cancers: a review study
Curr Mol Med. 2023 Aug 16. doi: 10.2174/1566524023666230816163031. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are transcribed RNA molecules longer than 200 nucleotides in length that have no protein-coding potential. They are able to react with DNA, RNA, and protein. Hence they involve in regulating gene expression at the epigenetic, transcriptional, post-transcriptional, and translational levels. LncRNAs have been proven to play an important role in human malignancies and prognostic outcomes. In this review, we will comprehensively and functionally discuss the role of a novel identified lncRNA, namely ln...
Source: Current Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Mohsen Sheykhhasan Fateme Karimi Dermani Nematollah Gheibi Ishwaree Datta Hamid Sadeghi Saeideh Gholamzadeh Khoei Source Type: research
MiR-148b caused liver injury in rats with traumatic hemorrhagic shock by inhibiting SIRT6 expression
CONCLUSION: Hepatocyte injury induced by I/R was achieved by regulating miR-148b /SIRT6 axis.PMID:37587827 | DOI:10.2174/1566524023666230816112629 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Xiongfei Ma Mingchen Liu Source Type: research
Exosomes derived from Mouse Bone Marrow Mesenchymal Stem Cells Attenuate Nucleus Pulposus Cell Apoptosis via the miR-155- 5p/Trim32 Axis
CONCLUSION: Overall, these findings suggest that exosomes from BMSCs can suppress TNF-α-induced cell cycle arrest and apoptosis in primary mouse NPCs through the delivery of miR-155-5p by targeting Trim32. This study provides a promising therapeutic strategy for IVDD.PMID:37587825 | DOI:10.2174/1566524023666230816090843 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Fei Chen Shangze Li Ji Wu Qunfeng Guo Haibin Wang Bin Ni Jun Yang Source Type: research
The emerging role of LncRNA AWPPH in multiple cancers: a review study
Curr Mol Med. 2023 Aug 16. doi: 10.2174/1566524023666230816163031. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are transcribed RNA molecules longer than 200 nucleotides in length that have no protein-coding potential. They are able to react with DNA, RNA, and protein. Hence they involve in regulating gene expression at the epigenetic, transcriptional, post-transcriptional, and translational levels. LncRNAs have been proven to play an important role in human malignancies and prognostic outcomes. In this review, we will comprehensively and functionally discuss the role of a novel identified lncRNA, namely ln...
Source: Current Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Mohsen Sheykhhasan Fateme Karimi Dermani Nematollah Gheibi Ishwaree Datta Hamid Sadeghi Saeideh Gholamzadeh Khoei Source Type: research
