Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy
CONCLUSION: Nef improved HN by inhibiting macrophages polarized to M1-type and pyroptosis by targeting the NLRC5/NLRP3 pathway. This research provides a scientific theoretical basis for the treatment of HN.PMID:38549521 | DOI:10.2174/0115665240272051240122074511 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Wei Yin Jin-Hua Wang Yu-Mei Liang Kang-Han Liu Ying Chen Yusa Chen Source Type: research
Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy
CONCLUSION: Nef improved HN by inhibiting macrophages polarized to M1-type and pyroptosis by targeting the NLRC5/NLRP3 pathway. This research provides a scientific theoretical basis for the treatment of HN.PMID:38549521 | DOI:10.2174/0115665240272051240122074511 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Wei Yin Jin-Hua Wang Yu-Mei Liang Kang-Han Liu Ying Chen Yusa Chen Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
CONCLUSION: Our study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.PMID:38500285 | DOI:10.2174/0115665240275029240306045214 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Zhongcheng Xie Jimin Yang Chunmeng Jiao Hui Chen Siyu Ouyang Zhiyang Liu Qin Hou Jifeng Liu Source Type: research
The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease
Curr Mol Med. 2024 Mar 7. doi: 10.2174/0115665240286793240306053111. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit...
Source: Current Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Jinfeng Su Haiyan Wang Zun Wang Source Type: research
The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease
Curr Mol Med. 2024 Mar 7. doi: 10.2174/0115665240286793240306053111. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit...
Source: Current Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Jinfeng Su Haiyan Wang Zun Wang Source Type: research
The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease
Curr Mol Med. 2024 Mar 7. doi: 10.2174/0115665240286793240306053111. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit...
Source: Current Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Jinfeng Su Haiyan Wang Zun Wang Source Type: research
The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease
Curr Mol Med. 2024 Mar 7. doi: 10.2174/0115665240286793240306053111. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit...
Source: Current Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Jinfeng Su Haiyan Wang Zun Wang Source Type: research
The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease
Curr Mol Med. 2024 Mar 7. doi: 10.2174/0115665240286793240306053111. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit...
Source: Current Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Jinfeng Su Haiyan Wang Zun Wang Source Type: research
