Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats
CONCLUSION: The IRF5 silencing alleviated neuropathic pain in CCI rats by downregulating the pain threshold, inflammatory cytokine levels, and CXCL13/CXCR5 signaling. IRF5 overexpression exacerbated the disease parameters of CCI-induced neuropathic pain in rats; however, they were reversed by neutralizing antibodies against CXCL13.PMID:37622691 | DOI:10.2174/1566524023666230825120836 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Jiawei Cao Chungu Hu Zhuofeng Ding Juan Chen Songhua Liu Qiongcan Li Source Type: research
Overexpressed microRNA (miR)-382-3p promoted vascular remodeling via suppressing autophagy-related protein 7 (ATG7) in chronic thromboembolic pulmonary hypertension
CONCLUSION: Overexpressed miR-382-3p promotes vascular remodeling via ATG7 inhibition in CTEPH.PMID:37608664 | DOI:10.2174/1566524023666230822120453 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Xiaona Feng Kaifeng Wang Ting Yang Bo Dang Xiaodong Wang Source Type: research
Overexpressed microRNA (miR)-382-3p promoted vascular remodeling via suppressing autophagy-related protein 7 (ATG7) in chronic thromboembolic pulmonary hypertension
CONCLUSION: Overexpressed miR-382-3p promotes vascular remodeling via ATG7 inhibition in CTEPH.PMID:37608664 | DOI:10.2174/1566524023666230822120453 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Xiaona Feng Kaifeng Wang Ting Yang Bo Dang Xiaodong Wang Source Type: research
Overexpressed microRNA (miR)-382-3p promoted vascular remodeling via suppressing autophagy-related protein 7 (ATG7) in chronic thromboembolic pulmonary hypertension
CONCLUSION: Overexpressed miR-382-3p promotes vascular remodeling via ATG7 inhibition in CTEPH.PMID:37608664 | DOI:10.2174/1566524023666230822120453 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Xiaona Feng Kaifeng Wang Ting Yang Bo Dang Xiaodong Wang Source Type: research
Molecular Targeting and Novel Therapeutic Approaches against Fungal Infections
CONCLUSION: This article may be helpful for the researchers working on the discovery and development of new antifungal works for resistance to fungal diseases.PMID:37606033 | DOI:10.2174/1566524023666230302123310 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Abhishek Kumar Priya Bansal Deepti Katiyar Surya Prakash Nidagurthi Guggilla Raghavendra Rao Source Type: research
Resveratrol: Targeting cancer stem cells and ncRNAs to overcome cancer drug resistance
Curr Mol Med. 2023 Aug 17. doi: 10.2174/1566524023666230817102114. Online ahead of print.ABSTRACTA major challenge in treating cancer is the development of drug resistance, which can result in treatment failure and tumor recurrence. Targeting cancer stem cells (CSCs) and non-coding RNAs (ncRNAs) with a polyphenolic substance called resveratrol has the ability to combat this problem by lowering cancer resistance to drugs and opening up new therapeutic options. Resveratrol alters the expression of genes related to self-renewal, modulating important signaling pathways involved in cancer initiation and CSC control. Additionall...
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Leila Rezakhani Sima Salmani Masoumeh Eliyasi Dashtaki Sorayya Ghasemi Source Type: research
Hydroquinidine demonstrates remarkable antineoplastic effects on non-small cell lung cancer cells
CONCLUSION: Our findings suggest that HQ has the potential to limit lung cancer growth as a novel potent anticarcinogenic agent. However, more investigations are needed to gain further insight into the mechanism of action of HQ and to evaluate its efficacy in in-vivo models.PMID:37592773 | DOI:10.2174/1566524023666230817115937 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Mervenur Yavuz Turan Demircan Source Type: research
