Dysregulated Long Non-coding RNAs in Myasthenia Gravis- A Mini-Review
Curr Mol Med. 2024 Jan 8. doi: 10.2174/0115665240281531231228051037. Online ahead of print.ABSTRACTMyasthenia gravis (MG) is an acquired autoimmune disease that is mediated by humoral immunity, supplemented by cellular immunity, along with participation of the complement system. The pathogenesis of MG is complex; although autoimmune dysfunction is clearly implicated, the specific mechanism remains unclear. Long non-coding RNAs (lncRNAs) are a class of non-coding RNA molecules with lengths greater than 200 nucleotides, with increasing evidence of their rich biological functions and high-level structure conservation. LncRNAs...
Source: Current Molecular Medicine - January 9, 2024 Category: Molecular Biology Authors: Liying Sun Xuhui Ye Linlin Wang Junping Yu Yan Wu Yun Hua Lihua Dai Source Type: research

Dysregulated Long Non-coding RNAs in Myasthenia Gravis- A Mini-Review
Curr Mol Med. 2024 Jan 8. doi: 10.2174/0115665240281531231228051037. Online ahead of print.ABSTRACTMyasthenia gravis (MG) is an acquired autoimmune disease that is mediated by humoral immunity, supplemented by cellular immunity, along with participation of the complement system. The pathogenesis of MG is complex; although autoimmune dysfunction is clearly implicated, the specific mechanism remains unclear. Long non-coding RNAs (lncRNAs) are a class of non-coding RNA molecules with lengths greater than 200 nucleotides, with increasing evidence of their rich biological functions and high-level structure conservation. LncRNAs...
Source: Current Molecular Medicine - January 9, 2024 Category: Molecular Biology Authors: Liying Sun Xuhui Ye Linlin Wang Junping Yu Yan Wu Yun Hua Lihua Dai Source Type: research

ADGRL4 Promotes Cell Growth, Aggressiveness, EMT, and Angiogenesis in Neuroblastoma via Activation of ERK/STAT3 Pathway
CONCLUSION: To conclude, the downregulation of ADGRL4 may inhibit cell growth, aggressiveness, EMT, and angiogenesis in NB by inactivating the ERK/STAT3 signaling pathway.PMID:38178660 | DOI:10.2174/0115665240254765231117122210 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Geng Geng Lei Zhang Ying Yu Xingqing Guo Qinghao Li Ming Ming Source Type: research

A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2-ARE Inhibiting Ferroptosis in Dopaminergic Neurons
CONCLUSION: Based on the transfection of P62 plasmid, it was found that P62 plasmid can inhibit the lipid peroxidation of iron death in dopaminergic nerve cells by activating the Nrf2 signaling pathway, thus playing a protective role in dopaminergic nerve cells.PMID:38178661 | DOI:10.2174/0115665240266555231120044938 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Yani Yao Peishan Li Sen Jiang Xinling Meng Hua Gao Xinling Yang Source Type: research

TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
CONCLUSION: The TPD52 gene may be important for human cancer treatment.PMID:38178662 | DOI:10.2174/0115665240260252230919054858 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Lu Miao Li Jing Buze Chen Tian Zeng Youguo Chen Source Type: research

ADGRL4 Promotes Cell Growth, Aggressiveness, EMT, and Angiogenesis in Neuroblastoma via Activation of ERK/STAT3 Pathway
CONCLUSION: To conclude, the downregulation of ADGRL4 may inhibit cell growth, aggressiveness, EMT, and angiogenesis in NB by inactivating the ERK/STAT3 signaling pathway.PMID:38178660 | DOI:10.2174/0115665240254765231117122210 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Geng Geng Lei Zhang Ying Yu Xingqing Guo Qinghao Li Ming Ming Source Type: research

A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2-ARE Inhibiting Ferroptosis in Dopaminergic Neurons
CONCLUSION: Based on the transfection of P62 plasmid, it was found that P62 plasmid can inhibit the lipid peroxidation of iron death in dopaminergic nerve cells by activating the Nrf2 signaling pathway, thus playing a protective role in dopaminergic nerve cells.PMID:38178661 | DOI:10.2174/0115665240266555231120044938 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Yani Yao Peishan Li Sen Jiang Xinling Meng Hua Gao Xinling Yang Source Type: research

TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
CONCLUSION: The TPD52 gene may be important for human cancer treatment.PMID:38178662 | DOI:10.2174/0115665240260252230919054858 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Lu Miao Li Jing Buze Chen Tian Zeng Youguo Chen Source Type: research

ADGRL4 Promotes Cell Growth, Aggressiveness, EMT, and Angiogenesis in Neuroblastoma via Activation of ERK/STAT3 Pathway
CONCLUSION: To conclude, the downregulation of ADGRL4 may inhibit cell growth, aggressiveness, EMT, and angiogenesis in NB by inactivating the ERK/STAT3 signaling pathway.PMID:38178660 | DOI:10.2174/0115665240254765231117122210 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Geng Geng Lei Zhang Ying Yu Xingqing Guo Qinghao Li Ming Ming Source Type: research

A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2-ARE Inhibiting Ferroptosis in Dopaminergic Neurons
CONCLUSION: Based on the transfection of P62 plasmid, it was found that P62 plasmid can inhibit the lipid peroxidation of iron death in dopaminergic nerve cells by activating the Nrf2 signaling pathway, thus playing a protective role in dopaminergic nerve cells.PMID:38178661 | DOI:10.2174/0115665240266555231120044938 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Yani Yao Peishan Li Sen Jiang Xinling Meng Hua Gao Xinling Yang Source Type: research

TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
CONCLUSION: The TPD52 gene may be important for human cancer treatment.PMID:38178662 | DOI:10.2174/0115665240260252230919054858 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Lu Miao Li Jing Buze Chen Tian Zeng Youguo Chen Source Type: research

ADGRL4 Promotes Cell Growth, Aggressiveness, EMT, and Angiogenesis in Neuroblastoma via Activation of ERK/STAT3 Pathway
CONCLUSION: To conclude, the downregulation of ADGRL4 may inhibit cell growth, aggressiveness, EMT, and angiogenesis in NB by inactivating the ERK/STAT3 signaling pathway.PMID:38178660 | DOI:10.2174/0115665240254765231117122210 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Geng Geng Lei Zhang Ying Yu Xingqing Guo Qinghao Li Ming Ming Source Type: research

A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2-ARE Inhibiting Ferroptosis in Dopaminergic Neurons
CONCLUSION: Based on the transfection of P62 plasmid, it was found that P62 plasmid can inhibit the lipid peroxidation of iron death in dopaminergic nerve cells by activating the Nrf2 signaling pathway, thus playing a protective role in dopaminergic nerve cells.PMID:38178661 | DOI:10.2174/0115665240266555231120044938 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Yani Yao Peishan Li Sen Jiang Xinling Meng Hua Gao Xinling Yang Source Type: research

TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
CONCLUSION: The TPD52 gene may be important for human cancer treatment.PMID:38178662 | DOI:10.2174/0115665240260252230919054858 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 5, 2024 Category: Molecular Biology Authors: Lu Miao Li Jing Buze Chen Tian Zeng Youguo Chen Source Type: research

IL-1 β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization
CONCLUSION: IL-1β-BMSC/exos alleviates sepsis by modulating the HMGB1/AKT pathway and triggering M2 macrophage polarization.PMID:38173202 | DOI:10.2174/0115665240277763231206051401 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Yang Li Zifa Sun Yuanyuan Li Jing Sun Biquan Chen Source Type: research