The Protective Effect of Curcumin Against Cardiotoxic Effects Induced by Chronic Exposure to Chlorpyrifos
CONCLUSION: According to the results of this study, Cur can reduce the adverse effects of long-term exposure to CPF in rat heart tissue by modulating OS.PMID:37877145 | DOI:10.2174/0115665240251646230919100920 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 25, 2023 Category: Molecular Biology Authors: Mahdi Abdollahi-Karizno Mahbobeh Chahkandi Shahnaz Rajabi Babak Roshanravan Amir Masoud Jafari-Nozad Michael Aschner Saeed Samarghandian Tahereh Farkhondeh Source Type: research
Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development
CONCLUSION: The diverse carcinogenic effect opens an argument into its potential role in inhibitory targeted therapy.PMID:37877563 | DOI:10.2174/0115665240251370231017053236 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 25, 2023 Category: Molecular Biology Authors: Elizabeth Gonzalez Terrie G Flatt Midhat Farooqi Lisa Johnson Atif A Ahmed Source Type: research
Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions
Curr Mol Med. 2023 Oct 24. doi: 10.2174/0115665240264547231017110613. Online ahead of print.ABSTRACTDementia in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB) is a progressive neurological condition affecting millions worldwide. The amphiphilic molecule GM2 gangliosides are abundant in the human brain and play important roles in neuronal development, intercellular recognition, myelin stabilization, and signal transduction. GM2 ganglioside's degradation requires hexosaminidase A (HexA), a heterodimer composed of an α subunit encoded by HEXA and a ...
Source: Current Molecular Medicine - October 25, 2023 Category: Molecular Biology Authors: Sanjesh Kumar Siva Prasad Panda Source Type: research
Functional Insight into hTRIR
Curr Mol Med. 2023 Oct 20. doi: 10.2174/0115665240260310231016112946. Online ahead of print.ABSTRACTThe uncharacterized C19orf43 was discovered to be associated with hTR maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61). hTRIR works in a broad range of temperatures and pH without any divalent cations needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In addition, hTRIR digested both ends of methylated small RNA, which suggested that it was a putative ribonuclease. Later, we designe...
Source: Current Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Jumin Xie Hui Mao Source Type: research
Functional Insight into hTRIR
Curr Mol Med. 2023 Oct 20. doi: 10.2174/0115665240260310231016112946. Online ahead of print.ABSTRACTThe uncharacterized C19orf43 was discovered to be associated with hTR maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61). hTRIR works in a broad range of temperatures and pH without any divalent cations needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In addition, hTRIR digested both ends of methylated small RNA, which suggested that it was a putative ribonuclease. Later, we designe...
Source: Current Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Jumin Xie Hui Mao Source Type: research
Functional Insight into hTRIR
Curr Mol Med. 2023 Oct 20. doi: 10.2174/0115665240260310231016112946. Online ahead of print.ABSTRACTThe uncharacterized C19orf43 was discovered to be associated with hTR maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61). hTRIR works in a broad range of temperatures and pH without any divalent cations needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In addition, hTRIR digested both ends of methylated small RNA, which suggested that it was a putative ribonuclease. Later, we designe...
Source: Current Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Jumin Xie Hui Mao Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes
CONCLUSION: It was concluded that hSF-MSCs and exosomes can be used in the treatment of cartilage damage, and hsa-miR-155-5p can be used as a target miRNA in a new gene therapy approach because it increases the therapeutic effect on cartilage damage.PMID:37859306 | DOI:10.2174/0115665240266016231014081916 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 20, 2023 Category: Molecular Biology Authors: Onur Uysal Haya Erybeh Mediha Canbek Emilia Qomi Ekenel Sibel Gunes G ülay Büyükköroğlu Tugba Semerci Sevimli Fatih Cemrek Ayla Eker Sariboyaci Source Type: research
Astragaloside IV Protects Against IL-1 β-Induced Chondrocyte Damage via Activating Autophagy
CONCLUSION: Our findings suggest that AS-IV mitigates inflammatory chondrocyte injury, safeguarding chondrocytes through a potential autophagy suppression mechanism. These results imply that AS-IV could offer preventive advantages for OA.PMID:37855351 | DOI:10.2174/0115665240249154231016080115 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 19, 2023 Category: Molecular Biology Authors: Hang Xu Jing-Bo Wang Yue-Ping Chen Wei Huang Zong-Bo We Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Interferon Signature's Members, a Novel Altered Correlation upon Interferon- β Treatment in Multiple Sclerosis Patients
CONCLUSION: The IFI44/MX1 axis could act as one of the crucial regulators of the disease following IFN-β treatment.PMID:37842895 | DOI:10.2174/0115665240251182231008040710 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 16, 2023 Category: Molecular Biology Authors: Sarvin Jabbari Mohammadali Hosseinpourfeizi Reza Safaralizadeh Behzad Baradaran Source Type: research
Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC
CONCLUSION: CSF, serum and urine metabolomic analyses could differentiate TBI DOC from NTBI DOC and functional analyses showed a metabolic change difference between TBI DOC and NTBI DOC.PMID:37817528 | DOI:10.2174/0115665240249826230928104512 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Xiaoping Xiao Long Xu Hezhen Lu Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Qianqian Ge Yutong Zhuang Xiaoli Geng Xueling Chen Ying Lan Jianghong He Wei Sun Source Type: research
