New echocardiographic indices of shift to biventricular failure to optimize risk stratification of chronic heart failure
AbstractAimsThe present study investigated the prognostic impact of either isolated left atrial (LA) impairment, or its association with right ventricular (RV) failure, in heart failure (HF) with reduced ejection fraction (HFrEF), using basic and speckle tracking echocardiography (STE).Methods and resultsOne hundred and six outpatients with HFrEF were enrolled in this prospective observational study. Patients with primary lung diseases, non-sinus rhythm, previous cardiac surgery, and poor acoustic window were excluded. After clinical examination and basic echocardiography, STE was used to measure peak atrial longitudinal s...
Source: ESC Heart Failure - December 8, 2021 Category: Cardiology Authors: Giulia Elena Mandoli, Maria Concetta Pastore, Giovanni Benfari, Martina Setti, Dan Nistor, Flavio D'Ascenzi, Marta Focardi, Bernardo Baccani, Giuseppe Patti, Serafina Valente, Sergio Mondillo, Matteo Cameli Tags: Original Article Source Type: research

Cancer and Takotsubo syndrome: from rarity to clinical practice
(Source: ESC Heart Failure)
Source: ESC Heart Failure - December 7, 2021 Category: Cardiology Authors: Kalliopi Keramida, Dimitrios Farmakis, Gerasimos Filippatos Tags: Editorial Source Type: research

Levosimendan for VA ‐ECMO weaning: the silver lining
(Source: ESC Heart Failure)
Source: ESC Heart Failure - December 7, 2021 Category: Cardiology Authors: Rasha Kaddoura, Mohamed Izham Mohamed Ibrahim, Amr Omar Tags: Letter to the Editor Source Type: research

Long ‐term prognostic value of vasodilator stress cardiac magnetic resonance in patients with atrial fibrillation
AbstractAimsAlthough the prevalence of coronary artery disease (CAD) is high among patients with atrial fibrillation (AF), studies on stress perfusion cardiac magnetic resonance (CMR) imaging frequently exclude patients with AF, and its prognostic and diagnostic value in high-risk patients with suspected or known CAD remains unclear.Methods and resultsIn this longitudinal cohort study, we included 164 consecutive patients with AF during vasodilator perfusion CMR. Diagnostic value was evaluated regarding invasive coronary angiography in a subset of patients. We targeted a follow-up of>5  years and used CMR results a...
Source: ESC Heart Failure - December 6, 2021 Category: Cardiology Authors: Karl J. Weiss, Sarah B. Nasser, Tamar Bigvava, Adelina Doltra, Bernhard Schnackenburg, Alexander Berger, Markus S. Anker, Christian Stehning, Patrick Doeblin, Mohamed Abdelmeguid, Mohamed Talat, Rolf Gebker, Wael E ‐Naggar, Burkert Pieske, Tags: Original Article Source Type: research

Prognostic impact of left atrial function in heart failure with preserved ejection fraction in sinus rhythm vs. persistent atrial fibrillation
AbstractAimsWe sought to determine the prognostic impact of left atrial (LA) size and function in patients with heart failure with preserved ejection fraction (HFpEF) in sinus rhythm (SR) vs. atrial fibrillation (AF).Methods and resultsWe enrolled consecutive HFpEF patients and assessed indexed LA volumes and emptying fractions (LA-EF) on cardiac magnetic resonance imaging. In addition, all patients underwent right and left heart catheterization, 6  min walk test, and N-terminal prohormone of brain natriuretic peptide evaluation. We prospectively followed patients and used Cox regression models to determine the associ...
Source: ESC Heart Failure - December 6, 2021 Category: Cardiology Authors: Robert Sch önbauer, Andreas A. Kammerlander, Franz Duca, Stefan Aschauer, Matthias Koschutnik, Carolina Dona, Christian Nitsche, Christian Loewe, Christian Hengstenberg, Julia Mascherbauer Tags: Original Article Source Type: research

Diabetes and treatment of chronic heart failure in a large real ‐world heart failure population
AbstractAimsAlthough diabetes mellitus (DM) is a common co-morbidity in chronic heart failure (HF) patients, European data on concurrent HF and DM treatment are lacking. Therefore, we have studied the HF treatment of patients with and without DM. Additionally, with the recent breakthrough of sodium –glucose cotransporter 2 (SGLT2) inhibitors in the field of HF, we studied the potential impact of this new drug in a large cohort of HF patients.Methods and resultsA total of 7488 patients with chronic HF with a left ventricular ejection fraction
Source: ESC Heart Failure - December 4, 2021 Category: Cardiology Authors: Sumant P. Radhoe, Jesse F. Veenis, Gerard C.M. Linssen, Chris Lee, Luc W.M. Eurlings, Hans Kragten, Nadea Y.Y. Al ‐Windy, Aukje Spank, Stefan Koudstaal, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts Tags: Original Article Source Type: research

Acute heart failure and iron deficiency: a prospective, multicentre, observational study
AbstractAimsThe prevalence and the natural course of iron deficiency (ID) in acute heart failure (AHF) are still unclear. We investigated the prevalence of ID in unselected patients admitted with AHF on admission, at discharge and up to 3  months thereafter.Methods and resultsIn this prospective, multicentre, observational study, 742 patients admitted with AHF were enrolled. The main study outcome was the percentage of patients with ID (ferritin
Source: ESC Heart Failure - December 4, 2021 Category: Cardiology Authors: Dirk H. Dalen, Johannes A. Kragten, Mireille E. Emans, Clara E.E. Ofwegen ‐Hanekamp, Claudia C.R. Klaarwater, Mireille H.A. Spanjers, Rémond Hendrick, Cees Th.B.M. Deursen, Hans‐Peter Brunner‐La Rocca Tags: Original Article Source Type: research

Body composition and maximal exercise capacity after heart transplantation
This study investigated the relationship between body composition and pVO2 during the first decade post-transplant.Methods and resultsBody composition was determined by dual-energy X-ray absorptiometry (DXA) and pVO2 by CPET in 48 HTR (n = 38 males; mean age 51 ± 12 years). A total of 95 assessments were acquired 1–9 years post-transplant, and the results of four consecutive periods were compared [Period 1: 1–2 years (n = 25); 2: 3–4 years (n = 23); 3: 5–6 years (n = 23); 4: 7–9 years (n = 24)]. Li...
Source: ESC Heart Failure - December 3, 2021 Category: Cardiology Authors: Julien Regamey, Pierre Monney, Patrick Yerly, Lucie Favre, Matthias Kirsch, Piergiorgio Tozzi, Olivier Lamy, Roger Hullin Tags: Original Research Article Source Type: research

Energy ‐sparing by 2‐methyl‐2‐thiazoline protects heart from ischaemia/reperfusion injury
AbstractAimsCardiac ischaemia/reperfusion (I/R) injury remains a critical issue in the therapeutic management of ischaemic heart failure. Although mild hypothermia has a protective effect on cardiac I/R injury, more rapid and safe methods that can obtain similar results to hypothermia therapy are required. 2-Methyl-2-thiazoline (2MT), an innate fear inducer, causes mild hypothermia resulting in resistance to critical hypoxia in cutaneous or cerebral I/R injury. The aim of this study is to demonstrate the protective effect of systemically administered 2MT on cardiac I/R injury and to elucidate the mechanism underlying this ...
Source: ESC Heart Failure - December 2, 2021 Category: Cardiology Authors: Masahiro Nishi, Takehiro Ogata, Ko Kobayakawa, Reiko Kobayakawa, Tomohiko Matsuo, Carlo Vittorio Cannistraci, Shinya Tomita, Shunta Taminishi, Takaomi Suga, Tomoya Kitani, Yusuke Higuchi, Akira Sakamoto, Yumika Tsuji, Tomoyoshi Soga, Satoaki Tags: Original Article Source Type: research

Risk factors for asymptomatic echocardiographic abnormalities that predict symptomatic heart failure
ConclusionsThe different risk factors for asymptomatic structural, systolic, and diastolic abnormalities that predict symptomatic HF, and the interactions between risk factors, illustrate how these structural, systolic, and diastolic abnormalities represent unique trajectories that lead to symptomatic HF. Improved understanding of these trajectories may assist in the design of HF prevention strategies. (Source: ESC Heart Failure)
Source: ESC Heart Failure - December 1, 2021 Category: Cardiology Authors: Jennifer M. Coller, Fei Fei Gong, Michele McGrady, Louise Shiel, Danny Liew, Simon Stewart, Alice J. Owen, Henry Krum, Christopher M. Reid, David L. Prior, Duncan J. Campbell Tags: Original Article Source Type: research

NT ‐proBNP as a marker for atrial fibrillation and heart failure in four observational outpatient trials
AbstractAimsHeart failure (HF) and atrial fibrillation (AF) frequently coexist and are both associated with increased levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP). It is known that AF impairs the diagnostic accuracy of NT-proBNP for HF. The aim of the present study was to compare the diagnostic and predictive accuracy of NT-proBNP for HF and AF in stable outpatients with cardiovascular risk factors.Methods and resultsData were obtained from the DIAST-CHF trial, a prospective cohort study that recruited individuals with cardiovascular risk factors and followed them up for 12  years. Data were validat...
Source: ESC Heart Failure - December 1, 2021 Category: Cardiology Authors: Stefanie M. Werhahn, Christian Becker, Meinhard Mende, Helge Haarmann, Kathleen Nolte, Ulrich Laufs, Samira Zeynalova, Markus L öffler, Nikolaos Dagres, Daniela Husser, Marcus Dörr, Stefan Gross, Stephan B. Felix, Astrid Petersmann, Christ Tags: Original Article Source Type: research

Evolutionary de Winter pattern: from STEMI to de Winter ECG —a case report
We report a case of a 34-year-old man with a history of smoking who presented to the local emergency department with a 49  min history of chest pain. The first ECG of the patient indicated that ST-segment elevation was noted in the lead V2–V4; 57 min later, a second ECG revealed a typical de Winter syndrome when the patient was transferred to the emergency chest pain centre of our hospital. A percutaneous coronary intervention (PCI) was performed approximately 8 h later because the patient initially refused the PCI. Acute coronary artery angiography showed that the proximal left anterior descending cor...
Source: ESC Heart Failure - December 1, 2021 Category: Cardiology Authors: Weijun Huang, Linlin Mai, Jianhua Lu, Wenshen Li, Yuli Huang, Yunzhao Hu Tags: Case Report Source Type: research

99mTechnetium ‐pyrophosphate scintigraphy: a practical guide for early diagnosis of transthyretin amyloid cardiomyopathy
AbstractTransthyretin amyloid cardiomyopathy (ATTR-CM) is caused by the cardiac deposition of insoluble amyloid fibrils formed by misfolded transthyretin proteins and is associated with various cardiac symptoms, such as progressive heart failure, conduction disturbance, and arrhythmia. The implementation of99mtechnetium (99mTc)-labelled bone radiotracer scintigraphy for diagnosing ATTR-CM has enabled accurate diagnosis of the disease with high sensitivity and specificity and positioned this diagnostic modality as an integral part of disease diagnostic algorithms. In 2020,99mTc-pyrophosphate scintigraphy received exceptiona...
Source: ESC Heart Failure - November 29, 2021 Category: Cardiology Authors: Nobuhiro Tahara, Olivier Lairez, Jin Endo, Atsushi Okada, Mitsuharu Ueda, Tomonori Ishii, Yoshinobu Kitano, Hahn ‐Ey Lee, Eleonora Russo, Toru Kubo Tags: Review Source Type: research

Aetiological classification and prognosis in patients with heart failure with preserved ejection fraction
ConclusionsAetiological classification provides clinical and prognostic information and may be useful to better decipher the clinical heterogeneity of HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 29, 2021 Category: Cardiology Authors: Antoine Fayol, Maxime Wack, Marine Livrozet, Jean ‐Baptiste Carves, Orianne Domengé, Eva Vermersch, Mariana Mirabel, Alexandre Karras, Julien Le Guen, Anne Blanchard, Michel Azizi, Laurence Amar, Marie‐Cécile Bories, Elie Mousseaux, Cl Tags: Original Article Source Type: research

Increasing home ‐time after a first diagnosis of heart failure in Sweden, 20 years trends
This study was performed to compare trends in home-time for patients with heart failure (HF) between those of working age and those of retirement age in Sweden from 1992 to 2012.Methods and resultsThe National Inpatient Register (IPR) was used to identify all patients aged 18 to 84  years with a first hospitalization for HF in Sweden from 1992 to 2012. Information on date of death, comorbidities, and sociodemographic factors were collected from the Swedish National Register on Cause of Death, the IPR, and the longitudinal integration database for health insurance and labour m arket studies, respectively. The patients ...
Source: ESC Heart Failure - November 28, 2021 Category: Cardiology Authors: Sofia Ekestubbe, Michael Fu, Kok Wai Giang, Martin Lindgren, Annika Rosengren, Linus Schioler, Maria Schaufelberger Tags: Original Article Source Type: research

Chronic kidney disease and risk of atrial fibrillation and heart failure in general population ‐based cohorts: the BiomarCaRE project
ConclusionsChronic kidney disease is an independent risk factor for subsequent AF and is even more closely associated with HF. In these relatively young participants with CKD, NT-proBNP was strongly associated with subsequent risk of AF. For HF, in addition, elevated levels of hs-C-reactive protein at baseline were related to incident events. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 26, 2021 Category: Cardiology Authors: Martin Rehm, Dietrich Rothenbacher, Licia Iacoviello, Simona Costanzo, Hugh Tunstall ‐Pedoe, Catherine A. Fitton, Stefan Söderberg, Johan Hultdin, Veikko Salomaa, Pekka Jousilahti, Tarja Palosaari, Kari Kuulasmaa, Christoph Waldeyer, Renat Tags: Original Article Source Type: research

The prognostic value of heart rate at discharge in acute decompensation of heart failure with reduced ejection fraction
AbstractAimsThe effect of elevated heart rate (HR) on morbidity and mortality is evident in chronic stable heart failure; data in this regard in acute decompensated heart failure (ADHF) setting are scarce. In this single-centre study, we sought to address the prognostic value of HR and beta-blocker dosage at discharge on all-cause mortality among patients with heart failure and reduced ejection fraction and ADHF.Methods and resultsIn this retrospective observational study, 2945 patients were admitted for the first time with the primary diagnosis of ADHF between January 2008 and February 2018. Patients were divided by resti...
Source: ESC Heart Failure - November 25, 2021 Category: Cardiology Authors: Fadel Bahouth, Adi Elias, Itai Ghersin, Emad Khoury, Omer Bar, Haitham Sholy, Johad Khoury, Zaher S. Azzam Tags: Original Article Source Type: research

Cytokine storm after heart transplantation in COVID ‐19‐related haemophagocytic lymphohistiocytosis (HLH)
AbstractWhile severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily causes inflammation in the respiratory system, there is growing evidence of extrapulmonary tissue damage mediated by the host innate immune system in children and adults. A cytokine storm can manifest as a viral-induced haemophagocytic lymphohistiocytosis (HLH). Here, we present a previously healthy 8-year-old boy with newly diagnosed cardiac injury and COVID-19-related HLH syndrome with haemophagocytosis in bone marrow biopsy. After remission of inflammation, the patient underwent a heart transplant due to persistent cardiac fai...
Source: ESC Heart Failure - November 25, 2021 Category: Cardiology Authors: Mohammad Mahdavi, Golnar Mortaz Hejri, Hamidreza Pouraliakbar, Hossein Shahzadi, Mahshid Hesami, Golnaz Houshmand Tags: Case Report Source Type: research

Performance of non ‐invasive myocardial work to predict the first hospitalization for de novo heart failure with preserved ejection fraction
AbstractAimsNon-invasive myocardial work (MW) is a validated index of left ventricular (LV) systolic performance, incorporating afterload and myocardial metabolism. The role of MW in predicting the first hospitalization forde novo heart failure with preserved ejection fraction (HFpEF) is still unknown. We aim to investigate the diagnostic performance of MW to predict the firstde novo HFpEF hospitalization in ambulatory individuals with preserved LV ejection fraction.Methods and resultsTwenty-nine patients with transthoracic echocardiography performed at least 6  months before the first HFpEF hospitalization were compa...
Source: ESC Heart Failure - November 25, 2021 Category: Cardiology Authors: Pasquale Paolisso, Emanuele Gallinoro, Niya Mileva, Ana Moya, Davide Fabbricatore, Giuseppe Esposito, Cristina De Colle, Monika Beles, Jerrold Spapen, Ward Heggermont, Carlos Collet, Guy Van Camp, Marc Vanderheyden, Emanuele Barbato, Jozef B Tags: Original Article Source Type: research

Integrating sex and gender in studies of cardiac resynchronization therapy: a systematic review
ConclusionsThere is a need to improve the study design, analysis, and completeness of reporting of sex in CRT cohort studies. Inadequate sex integration in study design and analysis may potentially hinder progress in understanding sex disparities in CRT. Deficiencies in the integration of sex in studies could be overcome by implementing guidance that already exists. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 25, 2021 Category: Cardiology Authors: Omar Dewidar, Irina Podinic, Victoria Barbeau, Dilan Patel, Alba Antequera, David Birnie, Vivian Welch, George A. Wells Tags: Original Article Source Type: research

Prediction of cardiac events with non ‐contrast magnetic resonance feature tracking in patients with ischaemic cardiomyopathy
ConclusionsThe impact of FT derived measurements in the risk stratification of patients with ICM depends on LV function. The combination of LV-GLS/RV-GRS seems to be a predictor of cardiovascular mortality and/or appropriate ICD therapy in patients with EF  >  35%. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 25, 2021 Category: Cardiology Authors: Daniel Overhoff, Uzair Ansari, Anna Hohneck, Erol T ülümen, Boris Rudic, Jürgen Kuschyk, Dirk Lossnitzer, Stefan Baumann, Matthias F. Froelich, Stephan Waldeck, Ibrahim Akin, Martin Borggrefe, Stefan O. Schoenberg, Theano Papavassiliu Tags: Original Article Source Type: research

Machine learning optimization of an electronic health record audit for heart failure in primary care
ConclusionsDiagnostic coding of HF in primary care health records is inaccurate with a high degree of under-registration and over-registration. An optimized query set enabled identification of more than 80% of GPs' self-assessed HF population. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 24, 2021 Category: Cardiology Authors: Willem Raat, Miek Smeets, Severine Henrard, Bert Aertgeerts, Joris Penders, Walter Droogne, Wilfried Mullens, Stefan Janssens, Bert Vaes Tags: Original Article Source Type: research

Long ‐term impact of β‐blocker in elderly patients without myocardial infarction after percutaneous coronary intervention
AbstractAimsLittle is known about the long-term outcomes of β-blockers use in patients with coronary artery disease (CAD) without myocardial infarction (MI) and reduced ejection fraction (rEF). However, more attention should be paid to the oral administration of β-blockers in elderly patients who are susceptible to heart failure (HF), sinus node dysfunctio n, or rate response insufficiency. We aimed to evaluate the long-term impact of β-blockers in elderly patients with CAD without MI or systolic HF who have undergone percutaneous coronary intervention.Methods and resultsA total of 1018 consecutive elderly p...
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Tatsuya Fukase, Tomotaka Dohi, Takuma Koike, Hidetoshi Yasuda, Mitsuhiro Takeuchi, Norihito Takahashi, Yuichi Chikata, Hirohisa Endo, Shinichiro Doi, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daid Tags: Original Article Source Type: research

Risk stratification in heart failure decompensation in the community: HEFESTOS score
AbstractAimsBecause evidence regarding risk stratification predicting prognosis of patients with heart failure (HF) decompensation attended in primary care is lacking, we developed and externally validated a model to forecast death/hospitalization during the first 30  days after an episode of decompensation. The predictive model is based on variables easily obtained in primary care settings.Methods and resultsHEFESTOS is a multinational study consisting of a derivation cohort of HF patients recruited in 14 primary healthcare centres in Barcelona and a validation cohort from primary healthcare in 9 other European count...
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Jos é‐María Verdu‐Rotellar, Rosa Abellana, Helene Vaillant‐Roussel, Lea Gril Jevsek, Radost Assenova, Djurdjica Kasuba Lazic, Peter Torsza, Liam George Glynn, Heidrun Lingner, Jacopo Demurtas, Hans Thulesius, Miguel Angel Muñoz, HEFES Tags: Original Article Source Type: research

Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure –A clinical practice Guideline Level 3
Conclusions This first evidence- and expert consensus-based guideline (level S3) on ECLS/ECMO therapy should be used to apply the best available care nationwide. Beyond clinical practice advice, remaining important research aspects for future scientific efforts are formulated. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Alexander Assmann, Andreas Beckmann, Christof Schmid, Karl Werdan, Guido Michels, Oliver Miera, Florian Schmidt, Stefan Klotz, Christoph Starck, Kevin Pilarczyk, Ardawan Rastan, Marion Burckhardt, Monika Nothacker, Ralf M üllenbach, York Za Tags: Original Article Source Type: research

Eligibility of patients with heart failure with preserved ejection fraction for sacubitril/valsartan according to the PARAGON ‐HF trial
AbstractAimsIn the heart failure (HF) with preserved ejection fraction (HFpEF) PARAGON-HF trial, sacubitril/valsartan vs. valsartan improved mortality/morbidity in patients with left ventricular ejection fraction (LVEF) below median (57%). We assessed eligibility for sacubitril/valsartan based on four scenarios.Methods and resultsEligibility was assessed in the Karolinska-Rennes study (acute HFpEF, LVEF  ≥ 45%, and N-terminal pro-B-type natriuretic peptide ≥300 pg/mL subsequently assessed as outpatients including echocardiography) in (i) a trial scenario (all trial criteria); (ii) a pragmatic scenario ...
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Lars H. Lund, Gianluigi Savarese, Ashwin Venkateshvaran, Lina Benson, Anna Lundberg, Erwan Donal, Jean ‐Claude Daubert, Emmanuel Oger, Cecilia Linde, Camilla Hage Tags: Original Article Source Type: research

Non ‐targeted metabolomics identify polyamine metabolite acisoga as novel biomarker for reduced left ventricular function
AbstractAimsChronic heart failure with reduced ejection fraction remains a major health issue. To date, no reliable biomarker is available to predict reduced left ventricular ejection fraction (LV-EF). We aimed to identify novel circulating biomarkers for reduced left ventricular function using untargeted serum metabolomics in two independent patient cohorts.Methods and resultsEchocardiography and non-targeted serum metabolomics were conducted in two patient cohorts with varying left ventricular function: (1) 25 patients with type 2 diabetes with established cardiovascular disease or high cardiovascular risk (LV-EF range 2...
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Andreas Puetz, Anna Artati, Jerzy Adamski, Katharina Schuett, Francesco Romeo, Robert Stoehr, Nikolaus Marx, Massimo Federici, Michael Lehrke, Ben A. Kappel Tags: Original Article Source Type: research

Aspirin use is associated with increased risk for incident heart failure: a patient ‐level pooled analysis
ConclusionsIn patients, at risk, aspirin use was associated with incident HF, independent of other risk factors. In the absence of conclusive trial evidence, our observations suggest that aspirins should be prescribed with caution in patients at risk of HF or having HF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 23, 2021 Category: Cardiology Authors: Blerim Mujaj, Zhen ‐Yu Zhang, Wen‐Yi Yang, Lutgarde Thijs, Fang‐Fei Wei, Peter Verhamme, Christian Delles, Javed Butler, Peter Sever, Roberto Latini, John GF Cleland, Faiez Zannad, Jan A. Staessen, Heart Omics in Ageing Investigators Tags: Original Article Source Type: research

Coronary angiography in patients with acute heart failure: from the KCHF registry
AbstractAimsLittle is known about the characteristics and outcomes of patients who undergo coronary angiography during heart failure (HF) hospitalization, as well as those with coronary stenosis, and those who underwent coronary revascularization.Methods and resultsWe analysed 2163 patients who were hospitalized for HF without acute coronary syndrome or prior HF hospitalization. We compared patient characteristics and 1  year clinical outcomes according to (i) patients with versus without coronary angiography, (ii) patients with versus without coronary stenosis, and (iii) patients with versus without coronary revascul...
Source: ESC Heart Failure - November 22, 2021 Category: Cardiology Authors: Yuta Seko, Takefumi Kishimori, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Yugo Yamashita, Takeshi Kitai, Ryoji Taniguchi, Moritake Iguchi, Kazuy Tags: Original Article Source Type: research

Clustering based on comorbidities in patients with chronic heart failure: an illustration of clinical diversity
ConclusionsDistinct combinations of comorbidities could be identified in patients with HF. Therapy may be tailored based on these clusters as next step towards precision medicine. The effect of such an approach needs to be prospectively tested. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 19, 2021 Category: Cardiology Authors: Nicole H.M.K. Uszko ‐Lencer, Daisy J.A. Janssen, Swetlana Gaffron, Lowie E.G.W. Vanfleteren, Eefje Janssen, Christ Werter, Frits M.E. Franssen, Emiel F.M. Wouters, Simon Rechberger, Hans‐Peter Brunner La Rocca, Martijn A. Spruit Tags: Original Article Source Type: research

With appreciation
(Source: ESC Heart Failure)
Source: ESC Heart Failure - November 19, 2021 Category: Cardiology Tags: List of Reviewers Source Type: research

Identifying patients at increased risk for poor outcomes from heart failure with reduced ejection fraction: the PROMPT ‐HF risk model
ConclusionsThe PROMPT-HF risk model can identify outpatients with HFrEF at increased risk of poor outcomes, including clinical events and health status deterioration. With further validation, this model may help inform therapeutic decision making. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 18, 2021 Category: Cardiology Authors: Adam D. DeVore, Claude Larry Hill, Laine E. Thomas, Nancy M. Albert, Javed Butler, J. Herbert Patterson, Adrian F. Hernandez, Fredonia B. Williams, Xian Shen, John A. Spertus, Gregg C. Fonarow Tags: Original Article Source Type: research

Impact of COVID ‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study)
AbstractAimsThe coronavirus disease-2019 (COVID-19) pandemic has changed the landscape of medical care delivery worldwide. We aimed to assess the influence of COVID-19 pandemic on hospital admissions and in-hospital mortality rate in patients with acute heart failure (AHF) in a retrospective, multicentre study.Methods and resultsFrom 1 January 2019 to 31 December 2020, a total of 101  433 patients were hospitalized in 24 Cardiology Departments in Poland. The number of patients admitted due to AHF decreased by 23.4% from 9853 in 2019 to 7546 in 2020 (P 
Source: ESC Heart Failure - November 17, 2021 Category: Cardiology Authors: Jacek Kubica, Ma łgorzata Ostrowska, Wioleta Stolarek, Michał Kasprzak, Klaudyna Grzelakowska, Jacek Kryś, Aldona Kubica, Piotr Adamski, Przemysław Podhajski, Eliano Pio Navarese, Edyta Anielska‐Michalak, Oliwia Brycht, Andrzej Curzytek, Tags: Original Article Source Type: research

Lower B ‐type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance
AbstractAimsNatriuretic peptides have reportedly been associated with cardiac hypertrophy and insulin resistance; however, it has not been established if B-type natriuretic peptide (BNP) is associated with either insulin resistance or cardiac remodelling in a population with normal plasma BNP levels. We investigated the relationship among plasma BNP levels, insulin resistance, and left ventricular (LV) remodelling in a population with normal physiological plasma BNP levels.Methods and resultsAmong 1632 individuals who participated in annual health checks between 2005 and 2008 in Arita-cho, Saga, Japan, 675 individuals [med...
Source: ESC Heart Failure - November 17, 2021 Category: Cardiology Authors: Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Tatsuro Hitsumoto, Ken Matsuoka, Seiji Takashima, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Shin Ito, Masafumi Kitakaze Tags: Original Article Source Type: research

Trends in survival of Swedish men and women with heart failure from 1987 to 2014: a population ‐based case–control study
AbstractAimsTo compare trends in short-term and long-term survival of patients with heart failure (HF) compared with controls from the general population.Methods and resultsWe used data from the Swedish National Inpatient Registry to identify all patients aged ≥18 years with a first recorded diagnosis of HF between 1 January 1987 and 31 December 2014 and compared them with controls matched on age and sex from the Total Population Register. We included 702 485 patients with HF and 1 306 183 controls. In patients with HF aged 18–64 years, short-ter m (29 days to 6 months) and long-...
Source: ESC Heart Failure - November 17, 2021 Category: Cardiology Authors: Lena Bj örck, Carmen Basic, Christina E. Lundberg, Tatiana Zverkova Sandström, Maria Schaufelberger, Annika Rosengren Tags: Original Article Source Type: research

Thromboembolism and bleeding in systemic amyloidosis: a review
AbstractThe assessment of both thromboembolic and haemorrhagic risks and their management in systemic amyloidosis have been poorly emphasized so far. This narrative review summarizes main evidence from literature with clinical perspective.The rate of thromboembolic events is as high as 5 –10% amyloidosis patients, at least in patients with cardiac involvement, with deleterious impact on prognosis. The most known pro-thrombotic factors are heart failure, atrial fibrillation, and atrial myopathy. Atrial fibrillation could occur in 20% to 75% of systemic amyloidosis patients. Cardiac thrombi are frequently observed in p...
Source: ESC Heart Failure - November 17, 2021 Category: Cardiology Authors: Martin Nicol, Virginie Siguret, Giuseppe Vergaro, Alberto Aimo, Michele Emdin, Jean Guillaume Dillinger, Mathilde Baudet, Alain Cohen ‐Solal, Camille Villesuzanne, Stephanie Harel, Bruno Royer, Bertrand Arnulf, Damien Logeart Tags: Review Source Type: research

The influence of comorbidities on achieving an N ‐terminal pro‐b‐type natriuretic peptide target: a secondary analysis of the GUIDE‐IT trial
AbstractAimsN-terminal pro-b-type natriuretic peptide (NT-proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these factors may influence the achievement of NT-proBNP targets and clinical outcomes.MethodsA total of 894 patients with heart failure with reduced ejection fraction were enrolled in The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment trial. NT-proBNP was analysed every 3  months.ResultsForty per cent of patients had AF, the median estimated glom...
Source: ESC Heart Failure - November 17, 2021 Category: Cardiology Authors: Justin A. Ezekowitz, Wendimagegn Alemayehu, Sarah Rathwell, Andrew D. Grant, Mona Fiuzat, David J. Whellan, Tariq Ahmad, Kirkwood Adams, Ileana L. Pi ña, Lawton S. Cooper, James L. Januzzi, Eric S. Leifer, Daniel Mark, Christopher M. O'Conno Tags: Original Article Source Type: research

Combined prognostic value of malnutrition using GLIM criteria and renal insufficiency in elderly heart failure
AbstractAimsWe aimed to investigate the prognostic impact of malnutrition, defined by the Global Leadership Initiative on Malnutrition (GLIM) criteria, stratified by renal function in hospitalized patients with acute decompensated heart failure (HF).Methods and resultsIn this retrospective study, 314 patients who were hospitalized for acute decompensated HF from August 2019 to October 2020 were enrolled. We evaluated malnutrition using the GLIM criteria during the time of admission. The primary outcome was 90-day all-cause mortality. The median patient age was 82 years, and 90-day mortality was 14.0%. In total, 76 (24.2%) ...
Source: ESC Heart Failure - November 16, 2021 Category: Cardiology Authors: Mitsutoshi Oguri, Hideki Ishii, Kenichiro Yasuda, Takuya Sumi, Hiroshi Takahashi, Toyoaki Murohara Tags: Original Article Source Type: research

Atrial appendage closure in patients with heart failure and atrial fibrillation: industry ‐independent single‐centre study
AbstractAimsTo evaluate outcomes of percutaneous left atrial appendage closure (LAAC) in patients with congestive heart failure (CHF) and non-valvular atrial fibrillation (AF) in a consecutive, industry-independent registry associated with periprocedural success and complications during long-term follow-up.Methods and resultsFor this analysis, we included patients who underwent transcatheter LAAC from January 2014 to December 2019 at the University Heart Center in L übeck, Germany, and compared patients with presence of CHF defined as patients with a reduced left ventricular ejection fraction (LVEF ≤ 40%)...
Source: ESC Heart Failure - November 16, 2021 Category: Cardiology Authors: Mohammed Saad, Mohamed Osman, Hosam Hasan ‐Ali, Mohammed Abdel Ghany, Mohamad A Alsherif, Osama Risha, Makoto Sano, Thomas Fink, Christian‐Hendrik Heeger, Julia Vogler, Vanessa Sciacca, Charlotte Eitel, Thomas Stiermaier, Alexander Joost, Tags: Original Article Source Type: research

Asymptomatic COVID ‐19 and ST‐elevation myocardial infarction in young adults: lessons learned from two similar cases
This report illustrates the challenges in clinical severity of STEMI with COVID-19 infection, despite of young age and absence of clinical symptoms and chronic co-morbidities. STEMI patients with even asymptomatic COVID-19 infection may be presented with significantly higher rates of severe acute heart failure. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 15, 2021 Category: Cardiology Authors: Hamayak Sisakian, Seda Martirosyan, Seda Shekoyan, Aram Terteryan, Mariam Hovhannisyan Tags: Case Report Source Type: research

Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure
AbstractAimsThe angiotensin receptor –neprilysin inhibitor (ARNI), sacubitril/valsartan, confers additional protective effects compared with angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEIs/ARBs) in terms of reversed left ventricular (LV) remodelling and improves the prognosis of patients with heart fa ilure (HF). However, few studies have examined the effects of ARNI on the left atrium. Accordingly, this study compared the effects of ARNI and ACEI/ARB on left atrial (LA) remodelling in heart failure with reduced ejection fraction (HFrEF).Methods and resultsThis was a single-centre ret...
Source: ESC Heart Failure - November 15, 2021 Category: Cardiology Authors: Yuxi Sun, Shuang Song, Yanli Zhang, Wenqiong Mo, Xinxin Zhang, Ning Wang, Yunlong Xia, Gary Tse, Ying Liu Tags: Original Article Source Type: research

Hierarchical management of chronic heart failure: a perspective based on the latent structure of comorbidities
This study aimed to explore the cluster model of CHF patients based on comorbidities and to verify their relationship with clinical outcomes.Methods and resultsElectronic health records of patients hospitalized with CHF from January 2014 to April 2019 were collected, and 12 common comorbidities were included in the latent class analysis. The Fruchterman –Reingold layout was used to draw the comorbidity network, and analysis of variance was used to compare the weighted degrees among them. The incidence of clinical outcomes among different clusters was presented on Kaplan–Meier curves and compared using the log-r...
Source: ESC Heart Failure - November 15, 2021 Category: Cardiology Authors: Chu Zheng, Linai Han, Jing Tian, Jing Li, Hangzhi He, Gangfei Han, Ke Wang, Hong Yang, Jingjing Yan, Bingxia Meng, Qinghua Han, Yanbo Zhang Tags: Original Article Source Type: research

Dose of furosemide before admission predicts diuretic efficiency and long ‐term prognosis in acute heart failure
AbstractAimsThe outpatient diuretic dose is a marker of diuretic resistance and prognosis in chronic heart failure (HF). Still, the impact of the preadmission dose on diuretic efficiency (DE) and prognosis in acute HF is not fully known.Methods and resultsWe conducted an observational and prospective study. All patients admitted for acute HF treated with intravenous diuretic and at least one criterion of congestion on admission were evaluated. Decongestion [physical examination, hemoconcentration, N-terminal pro-brain natriuretic peptide (NT-proBNP) change, and lung ultrasound], DE (weight loss and urine output per unit of...
Source: ESC Heart Failure - November 12, 2021 Category: Cardiology Authors: Zorba Bl ázquez‐Bermejo, Nuria Farré, Pedro Caravaca Perez, Marc Llagostera, Laura Morán‐Fernández, Aleix Fort, Javier Juan Bagudá, María Dolores García‐Cosio, Sonia Ruiz‐Bustillo, Juan F. Delgado Tags: Original Article Source Type: research

Left atrial unloading with an 8  mm septal cutting balloon to treat postcapillary pulmonary hypertension: a case report
We report the case of a 58-year-old female with severe postcapillary pulmonary hypertension (averaged mean pulmonary arterial pressure was 49  mmHg, pulmonary arterial wedge pressure 29 mmHg, and right atrial pressure 8 mmHg) due to heart failure with preserved ejection fraction. A left-to-right atrial shunt was created using an 8 mm cutting balloon, under transesophageal echocardiography guidance. Both pulmonary arterial and wedge pr essure dramatically decreased after the procedure. Symptoms immediately improved and benefits were sustained at 6 months of follow-up. This case suggests that iatroge...
Source: ESC Heart Failure - November 12, 2021 Category: Cardiology Authors: Fabrice Bauer, Emmanuel Besnier, Chadi Aludaat, Romain Breil, Nicolas Bettinger, Charles Fauvel, V éronique Wurtz, Olivier Raitiere, Nassima Si Belkacem, Najime Bouhzam Tags: Case Report Source Type: research

Phenotypic heterogeneity of COVID ‐19 pneumonia: clinical and pathophysiological relevance of the vascular phenotypea
Recent data support the existence of a distinctive ‘vascular’ phenotype with the involvement of both pulmonary parenchyma and its circulation in COVID-19 pneumonia. Its prompt identification is important for the accurate management of COVID-19 patients. The aim is to analyse the pro and contra of the different modalities to identify the ‘vascu lar’ phenotype. Chest computed tomography scan and angiogram may quantify both parenchyma and vascular damage, but the presence of thrombosis of pulmonary microcirculation may be missed. Increasedd-dimer concentration confirms a thrombotic state, but it cannot...
Source: ESC Heart Failure - November 10, 2021 Category: Cardiology Authors: Matteo Bertini, Emanuele D'Aniello, Luca Di Ienno, Federico Gibiino, Guido Tavazzi, Carlo Alberto Volta, Marco Contoli, Alberto Papi, Gianluca Campo, Roberto Ferrari, Claudio Rapezzi Tags: Review Source Type: research

Prognostic significance of unexplained left ventricular hypertrophy in patients undergoing carpal tunnel surgery
AbstractAimsCarpal tunnel (CT) syndrome is a recognized red-flag of cardiac amyloidosis (CA) and increased cardiovascular (CV) morbidity. We designed this study to characterize the CV profile of patients with CT syndrome at the time of first surgery and to identify high-risk presentations.Methods and resultsWe retrospectively reviewed 643 patients who underwent CT surgery between 2007 and 2019. Of them, 130 patients (77  years, 45% male patients, left ventricular ejection fraction 62%) with available CV characterization within ±12 months from CT surgery were included. Abnormal loading conditions causing ca...
Source: ESC Heart Failure - November 10, 2021 Category: Cardiology Authors: Aldostefano Porcari, Linda Pagura, Francesca Longo, Enrico Sfriso, Giulia Barbati, Luigi Murena, Emiliano Longo, Vittorio Ramella, Zoran Marij Arne ž, Claudio Rapezzi, Marco Merlo, Gianfranco Sinagra Tags: Original Research Article Source Type: research

The impact of a community ‐based heart failure multidisciplinary team clinic on healthcare utilization and costs
AbstractAimsMultidisciplinary team (MDT) management in heart failure (HF) is recommended to reduce mortality and HF hospitalization. We investigated whether an MDT in a community-based HF unit (HFU) impacted patients' healthcare utilization (HCU) and costs.Methods and resultsA retrospective cohort study was conducted among HF patients who visited at least once in a regional community-based HFU, established for ambulatory specialist care for New York Heart Association Functional Classes III and IV, between January 2012 and August 2019. HCU data were obtained from the health maintenance organization's claims data for 12 &nbs...
Source: ESC Heart Failure - November 8, 2021 Category: Cardiology Authors: Jean Marc Weinstein, Dan Greenberg, Amir Sharf, Tzahit Simon ‐Tuval Tags: Original Article Source Type: research

Less loop diuretic use in patients on sacubitril/valsartan undergoing remote pulmonary artery pressure monitoring
AbstractAimsControl of pulmonary pressures monitored remotely reduced heart failure hospitalizations mainly by lowering filling pressures through the use of loop diuretics. Sacubitril/valsartan improves heart failure outcomes and increases the kidney sensitivity for diuretics. We explored whether sacubitril/valsartan is associated with less utilization of loop diuretics in patients guided with haemodynamic monitoring in the CardioMEMS European Monitoring Study for Heart Failure (MEMS-HF).Methods and resultsThe MEMS-HF population (n = 239) was separated by the use of sacubitril/valsartan (n = 68) or no u...
Source: ESC Heart Failure - November 5, 2021 Category: Cardiology Authors: Michael B öhm, Birgit Assmus, Stefan D. Anker, Folkert W. Asselbergs, Johannes Brachmann, Marie‐Elena Brett, Jasper J. Brugts, Georg Ertl, AiJia Wang, Lutz Hilker, Friedrich Koehler, Stephan Rosenkranz, David M. Leistner, Amr Abdin, Jan W Tags: Original Article Source Type: research

Life impact of VA ‐ECMO due to primary graft dysfunction in patients after orthotopic heart transplantation
This study investigated days alive and out of hospital (DAOH) as patient-centred outcome in HTX patients at 1  year after surgery.Methods and resultsThis retrospective single-centre cohort study included patients who underwent HTX at the University Hospital D üsseldorf, Germany, from 2010 to 2020. Main exposure was VA-ECMO due to PGD. VA-ECMO and non-VA-ECMO patients were compared regarding the primary endpoint DAOH at 1 year after HTX. Subgroup analysis for patients weaned from VA-ECMO was performed. In total, 144 patients were included into analysis; 1 year mortality was significantly lower in non-ECM...
Source: ESC Heart Failure - November 4, 2021 Category: Cardiology Authors: Ren é M'Pembele, Sebastian Roth, Alexandra Stroda, Giovanna Lurati Buse, Stephan U. Sixt, Ralf Westenfeld, Amin Polzin, Philipp Rellecke, Igor Tudorache, Markus W. Hollmann, Hug Aubin, Payam Akhyari, Artur Lichtenberg, Ragnar Huhn, Udo Boek Tags: Original Article Source Type: research

Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort
ConclusionsThe heritability of natriuretic peptides appears relatively low (15%) and mainly based on the same gene cluster constituted ofMTHFR,CLCN6,NPPA,NPPB, andC1orf167. Natriuretic peptide polymorphisms are associated with natriuretic peptide levels and diastolic function. These results suggest that natriuretic peptide polymorphisms may have an impact in the early stages of cardiovascular and metabolic disease. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 4, 2021 Category: Cardiology Authors: Constance Xhaard, Rapha ël Rouget, Nicolas Vodovar, Edith Le Floch, Claire Dandine‐Roulland, Sandra Wagner, Delphine Bacq‐Daian, Quentin Thuillier, Jean‐Marc Boivin, Christiane Branlant, Jean‐François Deleuze, Isabelle Behm‐Ansmant, Tags: Original Article Source Type: research