Plasma testosterone and arrhythmic events in male patients with arrhythmogenic right ventricular cardiomyopathy
This study aimed to investigate the role of testosterone in predicting major adverse cardiac events in the Chinese AR VC cohort.Methods and resultsNinety ‐nine ARVC patients (median age, 40 years; 70.7% male) and 96 healthy controls (median age, 41 years; 62.5% male) were enrolled. The circulating levels of testosterone were measured by enzyme‐linked immunosorbent assays (ELISA). The median follow‐up time of all ARVC male patients was 17 mon ths (interquartile range/IQR 9–29). Cox proportional hazards regression was used to analyse the effect of plasma testosterone and other well‐described risk...
Source: ESC Heart Failure - May 29, 2020 Category: Cardiology Authors: Jie Ren, Liang Chen, Ningning Zhang, Xiao Chen, Qian Zhao, Kai Chen, Xiangjie Li, Frank Ruschitzka, Firat Duru, Jiangping Song Tags: Original Research Article Source Type: research

Impact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients
ConclusionsEvidence of MR in retrospective claims significantly increases the clinical burden of incident HF patients. Time to death and CV hospitalizations are increased when MR is clinically significant. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 29, 2020 Category: Cardiology Authors: David P. Cork, Peter A. McCullough, Hirsch S. Mehta, Colin M. Barker, Candace Gunnarsson, Michael P. Ryan, Erin R. Baker, Joanna Van Houten, Sarah Mollenkopf, Patrick Verta Tags: Original Research Article Source Type: research

Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis
AbstractAimsThe alarmin S100A8/S100A9 (S100A8/A9) is released by activated monocytes/macrophages and neutrophils in the setting lymphocytic myocarditis (MC). We recently demonstrated its therapeutic potential in experimental acute MC. Now, we investigated the diagnostic relevance of S100A8/A9 serum levels in patients with suspected acute and chronic MC and in patients with heart failure without cardiac inflammation.Methods and ResultsSerum S100A8/A9 levels were analysed in patients with a recent onset of MC [ ≤ 30 days,n = 32; ejection fraction (EF): 45.4 ± 12.9%], dilated cardiomyopathy ...
Source: ESC Heart Failure - May 28, 2020 Category: Cardiology Authors: Irene M üller, Thomas Vogl, Uwe Kühl, Alexander Krannich, Aron Banks, Tobias Trippel, Michel Noutsias, Alan S. Maisel, Sophie Linthout, Carsten Tschöpe Tags: Original Research Article Source Type: research

Anaemia, iron status, and gender predict the outcome in patients with chronic heart failure
AbstractAimsAnaemia and iron deficiency (ID) are frequently found in patients with chronic heart failure (CHF) and associated with adverse outcome. However, it is unclear whether absolute [transferrin saturation (TSAT)
Source: ESC Heart Failure - May 27, 2020 Category: Cardiology Authors: Katharina Kurz, Lukas Lanser, Markus Seifert, Florian Kocher, Gerhard P ölzl, Günter Weiss Tags: Original Research Article Source Type: research

Diagnostic and prognostic values of the QRS ‐T angle in patients with suspected acute decompensated heart failure
AbstractAimsThe aim of this study was to investigate the diagnostic and prognostic utility of the QRS ‐T angle, an electrocardiogram (ECG) marker quantifying depolarization–repolarization heterogeneity, in patients with suspected acute decompensated heart failure (ADHF).Methods and resultsWe prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive of ADHF. The QRS ‐T angle was automatically derived from a standard 12‐lead ECG recorded at presentation. The primary diagnostic endpoint was a final adjudicated diagnosis of ADHF. The primary prognostic endpoint was a...
Source: ESC Heart Failure - May 26, 2020 Category: Cardiology Authors: Romy Sweda, Zaid Sabti, Ivo Strebel, Nikola Kozhuharov, Desiree Wussler, Samyut Shrestha, Dayana Flores, Patrick Badertscher, Pedro Lopez ‐Ayala, Tobias Zimmermann, Eleni Michou, Danielle M. Gualandro, Andreas Häberlin, Hildegard Tanner, Tags: Original Research Article Source Type: research

Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study
We examined the association between coffee or tea consumption beginning in early adulthood and cardiac function in midlife.Methods and resultsWe investigated 2735 Coronary Artery Risk Development in Young Adults (CARDIA) study participants with long ‐term total caffeine intake, coffee, and tea consumption data from three visits over a 20 year interval and available echocardiography indices at the CARDIA Year‐25 exam (2010–2011). Linear regression models were used to assess the association between caffeine intake, tea, and coffee consumpt ion (independent variables) and echocardiography outcomes [LV mass, lef...
Source: ESC Heart Failure - May 25, 2020 Category: Cardiology Authors: Chike C. Nwabuo, Aisha S. Betoko, Jared P. Reis, Henrique T. Moreira, Henrique D. Vasconcellos, Eliseo Guallar, Christopher Cox, Stephen Sidney, Bharath Ambale ‐Venkatesh, Cora E. Lewis, Pamela J. Schreiner, Donald Lloyd‐Jones, Catarina I. Tags: Original Research Article Source Type: research

Carotid arterial mechanics as useful biomarker of extracellular matrix turnover and preserved ejection fraction heart failure
AbstractAimsWe aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF).Methods and resultsAmong 251 prospectively participants (mean age 66.0  ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two‐dimensional speckle tracking. We further related these carotid artery d...
Source: ESC Heart Failure - May 25, 2020 Category: Cardiology Authors: Kevin Ning Zhou, Kuo ‐Tzu Sung, Chih‐Hsuan Yen, Cheng‐Huang Su, Ping‐Ying Lee, Ta‐Chuan Hung, Wen‐Hung Huang, Shih‐Chieh Chien, Jui‐Peng Tsai, Chun‐Ho Yun, Shun‐Chuan Chang, Hung‐I Yeh, Chung‐Lieh Hung Tags: Original Research Article Source Type: research

Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant
AbstractAimsNephrotoxicity of calcineurin inhibitors (CNIs) is associated with adverse events in patients undergoing heart transplant (HTx), although studies directly comparing tacrolimus (TAC) versus cyclosporin A (CsA), especially in combination with everolimus and low ‐dose CNIs approach, are limited. Thus, we sought to investigate the associations of TAC and CsA with clinical outcomes in HTx recipients, with specific focus on renal function.Methods and resultsFrom August 2007 to February 2017, 72 consecutive patients (39 treated with TAC vs. 33 with CsA) receivingde novo HTx in a single transplant centre were retrosp...
Source: ESC Heart Failure - May 23, 2020 Category: Cardiology Authors: Yasuyuki Shiraishi, Eisuke Amiya, Masaru Hatano, Toshiomi Katsuki, Chie Bujo, Masaki Tsuji, Daisuke Nitta, Hisataka Maki, Junichi Ishida, Yukie Kagami, Miyoko Endo, Mitsutoshi Kimura, Masahiko Ando, Shogo Shimada, Osamu Kinoshita, Minoru On Tags: Original Research Article Source Type: research

Outcome comparison of mitral valve surgery and MitraClip therapy in patients with severely reduced left ventricular dysfunction
AbstractAimsThe aim of this study was to compare the outcomes of surgical mitral valve repair or replacement (sMVR) and percutaneous edge ‐to‐edge repair using MitraClip (pMVR) in patients with severe left ventricular dysfunction affected by functional mitral regurgitation (FMR).Methods and resultsWe retrospectively identified 132 patients with left ventricular ejection fraction (LVEF)  ≦ 30% submitted to sMVR (n = 47) or pMVR (n = 85) for FMR at our centre from January 2013 to December 2017. To adjust for baseline imbalances, we used a propensity score matching by age, logistic EuroSCOR...
Source: ESC Heart Failure - May 23, 2020 Category: Cardiology Authors: Takayuki Gyoten, S ören Schenk, Kristin Rochor, Volker Herwig, Axel Harnath, Oliver Grimmig, Sören Just, Dirk Fritzsche, Daniel Messroghli Tags: Original Research Article Source Type: research

Unmasking features of the auto ‐epitope essential for β1‐adrenoceptor activation by autoantibodies in chronic heart failure
ConclusionsThe conformational auto ‐epitope targeted by cardio‐pathogenic β1‐receptor autoantibodies is faithfully conserved in cyclopeptide homologues of the β1ECII loop bearing the NDPK211 –214 motif and the C209↔C215 bridge while lacking cysteine C216. Such molecules provide promising tools for novel diagnostic and therapeutic approaches in β1‐autoantibody‐positive CHF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 21, 2020 Category: Cardiology Authors: Angela W ölfel, Mathias Sättele, Christina Zechmeister, Viacheslav O. Nikolaev, Martin J. Lohse, Fritz Boege, Roland Jahns, Valérie Boivin‐Jahns Tags: Original Research Article Source Type: research

Unravel the genetic background of noncompaction before relating it with myocardial hypoperfusion
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 21, 2020 Category: Cardiology Authors: Claudia St öllberger, Josef Finsterer Tags: Letter to the Editor Source Type: research

Impact of plasma xanthine oxidoreductase activity in patients with heart failure with preserved ejection fraction
ConclusionsElevated plasma XOR activity is significantly associated with adverse clinical outcomes in patients with HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 20, 2020 Category: Cardiology Authors: Ken Watanabe, Tetsu Watanabe, Yoichiro Otaki, Tetsuro Shishido, Takayo Murase, Takashi Nakamura, Shigehiko Kato, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Masafumi Watanabe Tags: Original Research Article Source Type: research

Prognostic significance of right ventricular hypertrophy and systolic function in Anderson –Fabry disease
AbstractAimsRight ventricular hypertrophy (RVH) is a common finding in Anderson –Fabry disease (AFD), but the prognostic role of right ventricular (RV) involvement has never been assessed. The aim of our study was to evaluate the prognostic significance of RVH and RV systolic function in AFD.Methods and resultsForty ‐five AFD patients (56% male patients) with extensive baseline evaluation, including assessment of RVH and RV systolic function, were followed‐up for an average of 51.2 ± 11.4 months. RV systolic function was assessed by standard and tissue Doppler echocardiography. Cardiovascula...
Source: ESC Heart Failure - May 20, 2020 Category: Cardiology Authors: Francesca Graziani, Rosa Lillo, Elena Panaioli, Maurizio Pieroni, Antonia Camporeale, Elena Verrecchia, Ludovico Luca Sicignano, Raffaele Manna, Antonella Lombardo, Gaetano Antonio Lanza, Filippo Crea Tags: Original Research Article Source Type: research

MitraClip and left ventricular reverse remodelling: a strain imaging study
AbstractAimsThe purpose of this study is to identify echocardiography predictors of clinical response and reverse left ventricular (LV) remodelling in patients with functional mitral regurgitation (FMR) treated with MitraClip.Method and resultsWe retrospectively analysed 86 high surgical risk patients with severe FMR; of those, 58 were implanted a MitraClip, and 28 received medical treatment and served as controls. At baseline and at 1 ‐year follow‐up, we performed clinical and echocardiography evaluation to assess global longitudinal strain (GLS) and myocardial work [global work index (GWI), global constructive work (...
Source: ESC Heart Failure - May 20, 2020 Category: Cardiology Authors: Konstantinos Papadopoulos, Ignatios Ikonomidis, Michael Chrissoheris, Antonios Chalapas, Panagiota Kourkoveli, John Parissis, Konstantinos Spargias Tags: Original Research Article Source Type: research

Modifications of medical treatment and outcome after percutaneous correction of secondary mitral regurgitation
ConclusionsGuideline ‐directed medical therapy is frequently underdosed in HFrEF patients with SMR undergoing pMVR. Downtitration of medications after procedure is associated with poor prognosis. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 19, 2020 Category: Cardiology Authors: Davide Stolfo, Matteo Castrichini, Elena Biagini, Miriam Compagnone, Antonio De Luca, Thomas Caiffa, Alessandra Berardini, Giancarlo Vitrella, Renata Korcova, Andrea Perkan, Marco Foroni, Marco Merlo, Giulia Barbati, Francesco Saia, Claudio Tags: Original Research Article Source Type: research

Impella RP as a bridge to cardiac transplant for refractory late right ventricular failure in setting of left ventricular assist device
We report the first successful case of extended Impella RP use as a safe and effective bri dge to orthotopic heart transplant in an LVAD patient with refractory, haemodynamically significant late RV failure. The Impella RP provided support for 37 days. Haemodynamically intolerant arrhythmia precluded use of inotropic support. No adverse complications related to percutaneous Impella RP su pport were seen. We also review potential considerations for mechanical circulatory support strategies in this setting: central RV assist device cannulation requires sternotomy incision that can impact subsequent cardiac surgeries, wh...
Source: ESC Heart Failure - May 19, 2020 Category: Cardiology Authors: Varinder Kaur Randhawa, Karlee Hoffman, Ashley Bock, Pavan Bhat, Laura Young, Jeffrey Rossi, Joseph Campbell, Corrine Bott ‐Silverman, Edward G. Soltesz, Michael Z.Y. Tong, Shinya Unai, Ravi Nair, Jerry D. Estep, Antonio L. Perez Tags: Case Report Source Type: research

Speckle tracking echocardiography in hypokinetic non ‐dilated cardiomyopathy: comparison with dilated cardiomyopathy
AbstractAimsHypokinetic non ‐dilated cardiomyopathy (HNDC), which is determined by impaired left ventricular (LV) systolic function despite normal LV size, has been categorized as a subgroup of dilated cardiomyopathy (DCM) spectrum. Lack of data regarding advanced echocardiographic data in this population motivated us to des ign the present study in order to assess LV myocardial deformation properties of HNDC patients against the ones with dilated left ventricle.Methods and resultsThirty ‐one HNDC patients and 23 DCM patients were enrolled in the study consecutively. Myocardial deformation parameters including global l...
Source: ESC Heart Failure - May 19, 2020 Category: Cardiology Authors: Hoda Mombeini, Mozhgan Parsaee, Ahmad Amin Tags: Original Research Article Source Type: research

Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients
AbstractAimsIn heart failure (HF) with preserved ejection fraction (HFpEF), microvascular inflammation is proposed as an underlying mechanism. Myeloperoxidase (MPO) is associated with vascular dysfunction and prognosis in congestive HF.Methods and resultsMPO, MPO ‐related biomarkers, and echocardiography were assessed in 86 patients, 4–8 weeks after presentation with acute HF (EF ≥ 45%), and in 46 healthy controls. Patients were followed up for median 579 days (Q1;Q3 276;1178) regarding the composite endpoint all‐cause mortality or HF hospitaliza tion. Patients were 73 years old, 51% w...
Source: ESC Heart Failure - May 19, 2020 Category: Cardiology Authors: Camilla Hage, Erik Micha ëlsson, Bengt Kull, Tasso Miliotis, Sara Svedlund, Cecilia Linde, Erwan Donal, Jean‐Claude Daubert, Li‐Ming Gan, Lars H. Lund Tags: Original Research Article Source Type: research

Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player
AbstractHeart failure is a growing health issue as a negative consequence of improved survival upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large and complex pathology underlying heart failure makes diagnosis and especially treatment very difficult. There is an urgent demand for discriminative biomarkers to aid disease management of heart failure. Studying cellular pathways and pathophysiological mechanisms contributing to disease initiation and progression is crucial for understanding the disease process and will aid to identification of novel biomarkers and potential therapeutic ...
Source: ESC Heart Failure - May 18, 2020 Category: Cardiology Authors: Marian Wesseling, Julius H.C. Poel, Saskia C.A. Jager Tags: Review Source Type: research

Leucocyte count predicts cardiovascular risk in heart failure with preserved ejection fraction: insights from TOPCAT Americas
AbstractAimsPrior evidence has implicated leucocyte expansion in several cardiovascular disorders, including heart failure (HF) with reduced ejection fraction (rEF). However, the prognostic importance of leucocyte count in HF with preserved EF (HFpEF) remains largely unexplored.Methods and resultsThe Americas cohort of the treatment of preserved cardiac function heart failure with an aldosterone antagonist (TOPCAT ‐Americas) was used to evaluate the association between total leucocyte count and clinical outcomes in HFpEF. The primary outcome was a composite of aborted cardiac arrest, cardiovascular mortality, or hospital...
Source: ESC Heart Failure - May 18, 2020 Category: Cardiology Authors: Navkaranbir S. Bajaj, Rajat Kalra, Kartik Gupta, Sudeep Aryal, Indranee Rajapreyar, Steven G. Lloyd, Jonathan McConathy, Sanjiv J. Shah, Sumanth D. Prabhu Tags: Original Research Article Source Type: research

Potentially harmful drug prescription in elderly patients with heart failure with reduced ejection fraction
This study aimed to evaluate the prescription frequency of potentially harmful prescription drugs as defined in current heart failure guidelines among elderly patients with a diagnosis of heart failure with reduced ejection fraction and their association with clinical outcomes.Methods and resultsWe used the Centers for Medicare& Medicaid Services data from a nationally representative 5% sample for the years 2014 –2016 to identify patients admitted to acute care hospitals with a primary diagnosis of heart failure with reduced ejection fraction. The primary exposure was filling a prescription for a potentially harm...
Source: ESC Heart Failure - May 17, 2020 Category: Cardiology Authors: Paulino A. Alvarez, Yubo Gao, Saket Girotra, Amgad Mentias, Alexandros Briasoulis, Mary S. Vaughan Sarrazin Tags: Original Research Article Source Type: research

Echocardiographic assessment of insulin ‐like growth factor binding protein‐7 and early identification of acute heart failure
AbstractAimsConcentrations of insulin ‐like growth factor binding protein‐7 (IGFBP7) have been linked to abnormal cardiac structure and function in patients with chronic heart failure (HF), but cardiovascular correlates of the biomarker in patients with more acute presentations are lacking.We aimed to determine the relationship between IGFBP7 concentrations and cardiac structure and to evaluate the impact of IGFBP7 on the diagnosis of acute HF among patients with acute dyspnoea.Methods and resultsIn this pre ‐specified subgroup analysis of the International Collaborative of N‐terminal pro‐B‐type Natriuretic Pep...
Source: ESC Heart Failure - May 14, 2020 Category: Cardiology Authors: Arzu Kalayci, W. Frank Peacock, John T. Nagurney, Judd E. Hollander, Phillip D. Levy, Adam J. Singer, Nathan I. Shapiro, Richard K. Cheng, Chad M. Cannon, Andra L. Blomkalns, Elizabeth L. Walters, Robert H. Christenson, Annabel Chen ‐Tournou Tags: Original Research Article Source Type: research

Prognostic impact of nutritional status and physical capacity in elderly patients with acute decompensated heart failure
AbstractAimsNutritional status as well as physical capacity is related to prognosis in patients with heart failure. The purpose of this study was to explore a simple prognostic indicator in patients with acute decompensated heart failure (ADHF) by including both nutritional status and physical capacity.Methods and resultsPatients hospitalized with ADHF (N = 203; mean age, 81 years) were enrolled. We evaluated the geriatric nutritional risk index (GNRI) on hospital admission and at discharge. A GNRI score 
Source: ESC Heart Failure - May 14, 2020 Category: Cardiology Authors: Kaori Yasumura, Haruhiko Abe, Yoshinori Iida, Taishi Kato, Masayuki Nakamura, Chieko Toriyama, Hiroki Nishida, Akiko Idemoto, Kazuya Shinouchi, Tsuyoshi Mishima, Masaki Awata, Motoo Date, Yasunori Ueda, Masaaki Uematsu, Yukihiro Koretsune Tags: Original Research Article Source Type: research

Circulating protein biomarkers predict incident hypertensive heart failure independently of N ‐terminal pro‐B‐type natriuretic peptide levels
AbstractAimsHypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch ‐induced circulating biomarkers for predicting hypertension‐associated HF.Methods and resultsCirculating levels of 149 proteins were measured by proximity extension assay at baseline examination in 4742 individuals from the Malm ö Diet and Cancer study. Protein levels were compared with stretch‐activated gene expression changes in cultured neonatal rat ventricular myocytes (NRVMs) in response to 1–48 h of mechanical stretch. We also studied the association between p...
Source: ESC Heart Failure - May 14, 2020 Category: Cardiology Authors: Celine Fernandez, Jaana Rys ä, Kristoffer Ström, Jan Nilsson, Gunnar Engström, Marju Orho‐Melander, Heikki Ruskoaho, Olle Melander Tags: Original Research Article Source Type: research

Impacts of right ventricular function and venous congestion on renal response during depletion in acute heart failure
AbstractAimsVenous congestion is a major determinant of worsening renal function (WRF) in acute decompensated heart failure (ADHF), particularly when associated with right ventricular (RV) dysfunction. Whether the individual impacts of hemodynamic variables on renal outcomes in ADHF is modified according to RV function remains unclear. We aimed to determine the association between hemodynamic parameters and early changes in renal function during depletive therapy and explore the association of these changes with clinical outcomes.Methods and resultsWRF was defined as any increase in creatinine after 24  h of depletive...
Source: ESC Heart Failure - May 13, 2020 Category: Cardiology Authors: Nadia Bouabdallaoui, William Beaubien ‐Souligny, André Y. Denault, Jean L. Rouleau Tags: Original Research Article Source Type: research

Restrictive mitral annuloplasty with or without coronary artery bypass grafting in ischemic mitral regurgitation
This study included 309 patients with chronic MR and ischaemic cardiomyopathy for whom concomitant CABG was indicated (n = 225) or not indicated (n = 84) with RMA. The primary endpoint was all cause mortality during the follow‐up, and the secondary endpoint was defined as the composite of mortality and re‐admission for heart failure. Linear mixed model was used to analyse serial echocardiographic changes in LV function. To reduce the imp act of treatment bias and potential confounding in the direct comparisons between patients who underwent RMA with and those who underwent it without CABG, we establ...
Source: ESC Heart Failure - May 13, 2020 Category: Cardiology Authors: Satoshi Kainuma, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Takayoshi Ueno, Toru Kuratani, Haruhiko Kondoh, Takafumi Masai, Arudo Hiraoka, Taichi Sakaguchi, Hidenori Yoshita Tags: Original Research Article Source Type: research

Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing
AbstractAimsThis multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6 ‐month outcomes between LBBAP and biventricular pacing (BVP).Methods and resultsConsecutive patients with LBBB and left ventricular ejection fraction (LVEF)  ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity...
Source: ESC Heart Failure - May 13, 2020 Category: Cardiology Authors: Xiaofei Li, Chunguang Qiu, Ruiqin Xie, Wentao Ma, Zhao Wang, Hui Li, Hao Wang, Wei Hua, Shu Zhang, Yan Yao, Xiaohan Fan Tags: Original Research Article Source Type: research

Contemporary use of devices in chronic heart failure in the Netherlands
AbstractAimsDespite previous surveys regarding device implantation rates in heart failure (HF), insight into the real ‐world management with devices is scarce. Therefore, we investigated device implantation rates in HF with reduced left ventricular ejection fraction (LVEF) in 34 Dutch centres.Methods and resultsA cross ‐sectional outpatient registry was conducted in 6666 patients with LVEF 
Source: ESC Heart Failure - May 12, 2020 Category: Cardiology Authors: Anne G. Raafs, Gerard C.M. Linssen, Jasper J. Brugts, Ayten Erol ‐Yilmaz, Jacobus Plomp, Jeroen P.P. Smits, Michiel J. Nagelsmit, Remko M. Oortman, Arno W. Hoes, Hans‐Peter Brunner‐LaRocca Tags: Original Research Article Source Type: research

Association of pulmonary hypertension and right ventricular function with exercise capacity in heart failure
AbstractAimRelationships of pulmonary artery systolic pressure (PASP) and right ventricular (RV) dysfunction with exercise capacity are understudied. To assess the relationship of PASP and RV function with functional capacity and ventilatory efficiency in heart failure (HF) with a wide range of left ventricular ejection fraction (LVEF).Methods and resultsFive hundred thirty ‐two consecutive HF patients referred for cardiopulmonary exercise testing [percent predicted peak VO2 (ppVO2), VE/VCO2 slope] and echocardiography [LVEF, PASP, and RV fractional area change (RVFAC)] were studied. Associations of PASP and RVFAC with p...
Source: ESC Heart Failure - May 9, 2020 Category: Cardiology Authors: Kanako Teramoto, Morten Sengelov, Erin West, Mario Santos, Wilson Nadruz, Hicham Skali, Amil M. Shah Tags: Original Research Article Source Type: research

The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure
AbstractAimsMeasurement of B ‐type natriuretic peptide (BNP) or N‐terminal pro‐BNP is recommended as part of the diagnostic workup of patients with suspected heart failure (HF). We evaluated the diagnostic and prognostic utility of the novel urinary proteomic classifier HF1, compared with BNP, in HF. HF1 consists of 85 un ique urinary peptide fragments thought, mainly, to reflect collagen turnover.Methods and resultsWe performed urinary proteome analysis using capillary electrophoresis coupled with mass spectrometry in 829 participants. Of these, 622 had HF (504 had chronic HF and 118 acute HF) and 207 were controls ...
Source: ESC Heart Failure - May 8, 2020 Category: Cardiology Authors: Ross T. Campbell, Adam Jasilek, Harald Mischak, Esther Nkuipou ‐Kenfack, Agnieszka Latosinska, Paul I. Welsh, Colette E. Jackson, Jane Cannon, Alex McConnachie, Christian Delles, John J.V. McMurray Tags: Original Research Article Source Type: research

Ethnic differences in atrial fibrillation among patients with heart failure in Asia
ConclusionsAmong patients with HF across Asia, clinical correlates and adverse outcomes associated with AF are similar across ethnicities; however, there are striking ethnic variations in the prevalence of AF that are not accounted for by known risk factors. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 8, 2020 Category: Cardiology Authors: Eugene S.J. Tan, Vera Goh, Bernadet T. Santema, Wan Ting Tay, Tiew ‐Hwa Katherine Teng, Jonathan Yap, Jasper Tromp, Chung‐Lieh Hung, Vijay Chopra, Inder Anand, Michael R. MacDonald, Lieng Hsi Ling, ASIAN‐HF investigators, Isabelle C. Va Tags: Original Research Article Source Type: research

Recurrent heart failure hospitalizations are associated with increased cardiovascular mortality in patients with heart failure in Clinical Practice Research Datalink
ConclusionsThere is a strong association between recurrent HFH and CV mortality, with the risk increasing progressively with each recurrent HFH. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 8, 2020 Category: Cardiology Authors: Raquel Lahoz, Ail ís Fagan, Martin McSharry, Clare Proudfoot, Stefano Corda, Rachel Studer Tags: Original Research Article Source Type: research

Exhaled breath acetone for predicting cardiac and overall mortality in chronic heart failure patients
ConclusionsThis study shows that EBA levels reflect clinical HF features, especially right HF signs/symptoms. EBA is an independent predictor of cardiac and overall mortality in chronic HF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 7, 2020 Category: Cardiology Authors: Fabiana G. Marcondes ‐Braga, Luciana Gioli‐Pereira, Sabrina Bernardez‐Pereira, Guilherme L. Batista, Sandrigo Mangini, Victor S. Issa, Fabio Fernandes, Edimar A. Bocchi, Silvia M. Ayub‐Ferreira, Alfredo J. Mansur, Ivano G.R. Gutz, Jose Tags: Original Research Article Source Type: research

Renoprotective effect of tolvaptan in patients with new ‐onset acute heart failure
This study aimed to investigate the renoprotective effect of tolvaptan in patients hospitalized with new‐onset AHF.Methods and resultsA total of 122 consecutive patients hospitalized with new ‐onset AHF between May 2015 and December 2018 were retrospectively evaluated. WRF was defined as an absolute increase in serum creatinine ≥0.3 mg/dL (≥26.4 μmol/L) within 48 h or a 1.5‐fold increase in serum creatinine after hospitalization. The furosemide group (n = 75) and the tolvaptan add‐on group (n = 47) were compared. The tolvaptan group consists of patients who received tolva...
Source: ESC Heart Failure - May 7, 2020 Category: Cardiology Authors: Hiromi Kin, Koichiro Matsumura, Yoshihiro Yamamoto, Kenichi Fujii, Munemitsu Otagaki, Hiroki Takahashi, Haengnam Park, Kei Yoshioka, Mitsuru Yokoi, Tetsuro Sugiura, Ichiro Shiojima Tags: Original Research Article Source Type: research

Utility of single ‐item questions to assess physical inactivity in patients with chronic heart failure
AbstractAimThe purpose of this study was to explore the utility of two single ‐item self‐report (SR) questions to assess physical inactivity in patients with heart failure (HF).Methods and resultsThis is a cross ‐sectional study using data from 106 patients with HF equipped with accelerometers for 1 week each. Two SR items relating to physical activity were also collected. Correlations between accelerometer activity counts and the SR items were analysed. Patients were classified as physically active or i nactive on the basis of accelerometer counts, and the SR items were used to try to predict that classificatio...
Source: ESC Heart Failure - May 6, 2020 Category: Cardiology Authors: Andreas Blomqvist, Maria B äck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma Tags: Original Research Article Source Type: research

Risk assessment in PAH using quantitative CMR tricuspid regurgitation: relation to heart catheterization
ConclusionsA clear trend towards worse outcome with larger TRV or TR% was shown; however, the number of events was insufficient for significant outcome differences. Prognostic value of quantitative TR should be investigated in a larger multicentre cohort. Effective RV ejection fraction may be considered an improved measure of RV function in PAH. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 6, 2020 Category: Cardiology Authors: Erik Hedstr öm, Anna Bredfelt, Göran Rådegran, Håkan Arheden, Ellen Ostenfeld Tags: Original Research Article Source Type: research

Mildly symptomatic heart failure with reduced ejection fraction: diagnostic and therapeutic considerations
ConclusionsMildly symptomatic status in a patient with HFrEF is very frequent; it should not be ignored and should not be regarded as an index of disease stability. The application of risk scores designed to predict mortality and mode of death should be engaged among mildly symptomatic patients, not only to identify the most suitable HF candidates for cardioverter defibrillator implantation, but also to identify patients who might benefit from early intensification of medical treatment before the implementation of more interventional approaches. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 5, 2020 Category: Cardiology Authors: Alexandra Arvanitaki, Eleni Michou, Andreas Kalogeropoulos, Haralambos Karvounis, George Giannakoulas Tags: Review Source Type: research

Introduction of sacubitril/valsartan in primary care follow ‐up of heart failure: a prospective observational study (THESEUS)
ConclusionsResults from THESEUS suggest that transition to sac/val is manageable in primary care, with a safety profile corresponding to reports from specialized heart failure care. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 5, 2020 Category: Cardiology Authors: Thomas Dieterle, Stefan Schaefer, Ina Meyer, Gabriele Ackermann, Kashan Ahmed, Roger Hullin Tags: Original Research Article Source Type: research

Race ‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction
ConclusionOur comparative analyses of fatty acids and respective cyclooxygenase ‐derived and lipoxygenase‐derived SPM signatures capture the heterogeneity of disease pathology and elucidate potential mechanisms underlying sex‐based and race‐based differences following MI. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 4, 2020 Category: Cardiology Authors: Ganesh V. Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A. Limdi Tags: Original Research Article Source Type: research

Echocardiographic analysis of acute effects of percutaneous mitral annuloplasty on severity of secondary mitral regurgitation
AbstractAimsPercutaneous mitral annuloplasty (PMA) represents a new treatment option for secondary mitral regurgitation (SMR) being associated with higher morbidity and mortality. The present study was aimed to evaluate whether or not acute effects on SMR severity can quantitatively be assessed after PMA.Methods and resultsPMA was performed in 30 patients (mean age 76  ± 9; 37% males) with moderate (n = 14) or severe (n = 16) SMR. Vena contracta (VC), left ventricular (LV) velocity‐time‐integral ratio (VTIMV/LVOT), effective regurgitant orifice area (EROA) by two ‐dimensional prox...
Source: ESC Heart Failure - May 2, 2020 Category: Cardiology Authors: Stephan St öbe, Kristin Kreyer, Daniel Jurisch, Dietrich Pfeiffer, Daniel Lavall, Gerardo Farese, Ulrich Laufs, Andreas Hagendorff Tags: Original Research Article Source Type: research

Circulating biomarkers and cardiac function over 3  years after chemotherapy with anthracyclines: the ICOS‐ONE trial
ConclusionsFirst ‐in‐life CT with median cumulative dose of anthracyclines of 180 mg/m2 does not seem to cause clinically significant cardiac injury, as assessed by circulating biomarkers and echocardiography, in patients aged 51  years (median), without pre‐existing cardiac disease. This may suggest either a 100% efficacy of enalapril (given as preventive or troponin‐triggered) or a reassuringly low absolute cardiovascular risk in this cohort of patients, which may not require intensive cardiologic follow‐up. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2020 Category: Cardiology Authors: Jennifer M.T.A. Meessen, Daniela Cardinale, Fabio Ciceri, Maria Teresa Sandri, Maurizio Civelli, Barbara Bottazzi, GianFranco Cucchi, Elisabetta Menatti, Maurizio Mangiavacchi, Gianluigi Condorelli, Enrico Barbieri, Stefania Gori, Alessandro C Tags: Original Research Article Source Type: research

Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies
ConclusionsComprehensive familial screening including genetic testing in case of acute myocarditis associated with a family history of cardiomyopathy or sudden death revealed unknown or misdiagnosed arrhythmogenic variant carriers with left ‐dominant phenotypes that frequently evade arrhythmogenic right ventricular cardiomyopathy Task Force criteria. In view of our results, acute myocarditis should be considered as an additional criterion for arrhythmogenic cardiomyopathy, and genetic testing should be advised in patients who experie nce acute myocarditis and have a family history of cardiomyopathy or sudden death. (Sour...
Source: ESC Heart Failure - May 1, 2020 Category: Cardiology Authors: Nicolas Piriou, Lara Marteau, Florence Kyndt, Jean Michel Serfaty, Claire Toquet, Laurianne Le Gloan, Karine Warin ‐Fresse, Damien Guijarro, Thierry Le Tourneau, Emilie Conan, Aurélie Thollet, Vincent Probst, Jean‐Noël Trochu Tags: Original Research Article Source Type: research

The heart failure specialists of tomorrow: a network for young cardiovascular scientists and clinicians
AbstractThe “Heart failure specialists of Tomorrow” (HoT) group gathers young researchers, physicians, basic scientists, nurses and many other professions under the auspices of the Heart Failure Association of the European Society of Cardiology. After its foundation in 2014, it has quickly grown to a large group of currently 925 members. Membership in this growing community offers many advantages during, before, and after the ‘Heart Failure and World Congress on Acute Heart Failure’. These include: eligibility to receive travel grants, participation in moderated poster sessions and young researche r...
Source: ESC Heart Failure - April 30, 2020 Category: Cardiology Authors: Markus S. Anker, Claire Bouleti, Theodoros Christodoulides, Angela Durante, Edit Gara, Sara Hadzibegovic, Kalliopi Keramida, Alessia Lena, Angela Massouh, Ivan Milinkovic, Matthias P. N ägele, Alexander Nossikoff, Rui Plácido, Tamás Radovi Tags: Short Communication Source Type: research

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure
ConclusionsGRK2 is a critical molecule in the physiological regulation of cardiac metabolism. Its alterations in the failing heart can be pharmacologically targeted, leading to the correction of metabolic and functional abnormalities observed in HF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 30, 2020 Category: Cardiology Authors: Michele Ciccarelli, Daniela Sorriento, Antonella Fiordelisi, Jessica Gambardella, Antonietta Franco, Carmine Giudice, Marina Sala, Maria Gaia Monti, Alessia Bertamino, Pietro Campiglia, Marco Oliveti, Paolo Poggio, Giovanna Trinchese, Gina Ca Tags: Original Research Article Source Type: research

Effects of canagliflozin in patients with type 2 diabetes and chronic heart failure: a randomized trial (CANDLE)
ConclusionsThis study did not meet the predefined primary endpoint of changes in NT ‐proBNP levels, with 24 weeks of treatment with canagliflozin vs. glimepiride. Further research is warranted to determine whether patients with heart failure with preserved ejection fraction, regardless of diabetes status, could potentially benefit from treatment with SGLT2 inhibitors. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 29, 2020 Category: Cardiology Authors: Atsushi Tanaka, Itaru Hisauchi, Isao Taguchi, Akira Sezai, Shigeru Toyoda, Hirofumi Tomiyama, Masataka Sata, Shinichiro Ueda, Jun ‐ichi Oyama, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node, on behalf of the CANDLE Trial Investigators Tags: Original Research Article Source Type: research

Two cases of successful treatment of acute right heart failure with Impella RP ®
We report the perioperative course of the patients as well as their condition at 1 year follow‐up. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 29, 2020 Category: Cardiology Authors: David Santer, Anita Boltres, Luca Koechlin, Patrick Hunziker, Raban Jeger, Markus Maurer, Martin Grapow, Friedrich Eckstein, Oliver Reuthebuch Tags: Case Report Source Type: research

Fabry cardiomyopathy: Gb3 ‐induced auto‐reactive panmyocarditis requiring heart transplantation
AbstractResistance to enzyme replacement therapy (ERT) is a major therapeutic challenge in Fabry disease (FD). Recent reports attribute to immune ‐mediated inflammation a main role in promoting disease progression and resistance to ERT. Aim of the study is to report a Gb3‐induced auto‐reactive panmyocarditis causing inefficacy of ERT and severe electrical instability, which required cardiac transplantation. Examining the explanted heart from a 57‐year‐old man with FD cardiomyopathy (CM) on 3‐year ERT presenting incoming ventricular fibrillation, we documented a severe virus‐negative myocarditis extended to ca...
Source: ESC Heart Failure - April 29, 2020 Category: Cardiology Authors: Andrea Frustaci, Maurizio Scarpa, Rosalia Maria da Riol, Chiara Agrati, Nicoletta Finato, Romina Verardo, Claudia Grande, Cristina Chimenti, Concetta Nora, Matteo Antonio Russo, Ugolini Livi Tags: Case Report Source Type: research

Idiopathic giant cell myocarditis or cardiac sarcoidosis? A retrospective audit of a nationwide case series
ConclusionsRecognizing granulomas in or outside the heart remains a challenge for the pathologist. Given that CS and GCM are considered distinct diseases and granulomas exclusive of GCM, many cases of GCM, if thoroughly scrutinized, may need reclassification as CS. However, whether CS and GCM are truly different entities or parts of a one ‐disease continuum has not yet been conclusively settled. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 28, 2020 Category: Cardiology Authors: Kaj Ekstr öm, Anne Räisänen‐Sokolowski, Jukka Lehtonen, Hanna‐Kaisa Nordenswan, Mikko I. Mäyränpää, Markku Kupari Tags: Original Research Article Source Type: research

Motivational interviewing to improve self ‐care in heart failure patients (MOTIVATE‐HF): a randomized controlled trial
ConclusionsMI significantly improved self ‐care in HF patients. Including caregivers may potentiate the effect, especially in self‐care management.ClinicalTrial.gov, identifier: NCT02894502. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 28, 2020 Category: Cardiology Authors: Ercole Vellone, Paola Rebora, Davide Ausili, Valentina Zeffiro, Gianluca Pucciarelli, Gabriele Caggianelli, Stefano Masci, Rosaria Alvaro, Barbara Riegel Tags: Original Research Article Source Type: research

Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy
ConclusionsAdolescent RHR is associated with future risk of HF, regardless of associated aetiological condition. The association was strongest for HF associated with CM, driven by the association with dilated CM. These findings indicate a causal pathway between elevated RHR and myocardial dysfunction that warrants further investigation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 28, 2020 Category: Cardiology Authors: Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren Tags: Original Research Article Source Type: research