Women with peripartum cardiomyopathy have normal ejection fraction, but abnormal systolic strain, during pregnancy
We report a case series of six women with peripartum cardiomyopathy (PPCM) who incidentally underwent echocardiography prior to the clinical presentation of PPCM. For comparison, we identified controls, matched 2:1 on age, race, body mass index, gestational age, and hypertensive disorder. Among the six cases, all were diagnosed with PPCM during the post ‐partum period. Pre‐PPCM echocardiograms were performed between 17.7 weeks of gestation and 13 days post‐partum. Baseline left ventricular ejection fraction and size were normal and similar to the 12 matched controls (60% ± 6.6% vs. 61.4%&nb...
Source: ESC Heart Failure - May 4, 2021 Category: Cardiology Authors: Ruth Tamrat, Yu Kang, Marielle Scherrer ‐Crosbie, Lisa D. Levine, Zoltan Arany, Jennifer Lewey Tags: Case Report Source Type: research

Thirst distress in outpatients with heart failure in a Mediterranean zone of Spain
This study aimed to evaluate psychometric properties of the Spanish version of the Thirst Distress Scale for patients with Heart Failure (TDS ‐HF) and to describe thirst distress‐associated factors in outpatients at a heart failure (HF) clinic in Spain. Thirst is common in patients with HF, but thirst distress has rarely been addressed and may significantly decrease quality of life.Methods and resultsA cross ‐sectional study was performed assessing perceived thirst distress by patients with HF during the preceding 3 days, with the TDS‐HF (scores 8 to 40). Univariable and multivariable linear regression analyse...
Source: ESC Heart Failure - May 4, 2021 Category: Cardiology Authors: Sanna Hagelberg Eng, Nana Waldr éus, Beatriz González, Jenny Ehrlin, Violeta Díaz, Carmen Rivas, Patricia Velayos, María Puertas, Alba Ros, Paula Martín, Josep Lupón, Antoni Bayes‐Genis, Tiny Jaarsma Tags: Original Research Article Source Type: research

Corrigendum
(Source: ESC Heart Failure)
Source: ESC Heart Failure - May 4, 2021 Category: Cardiology Tags: Corrigendum Source Type: research

Inhalation of publicly available indoor insecticide spray caused myocardial infarction type II: a case report
We report on a 70 ‐year‐old woman who tried to eliminate ants from her kitchen by applying a publicly available insecticide spray. Immediately afterwards, she felt dyspnoea, superseded by heavy chest pain. High‐sensitivity troponin concentration increased from 33 to 149 ng/L (cut‐off 50 ng/L). Significant c oronary stenosis was excluded by coronary angiography, and the myocardial damage was classified as myocardial infarction type II. After exclusion of other potential mechanisms, we consider a cardiotoxic effect of the insecticide mixture of cypermethrin, tetramethrin, and piperonyl butoxide possible. We...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Dirk Habedank, Beate Stubbe, Ralf Ewert, Alexandra Kroll, Iskandar Atmowihardjo, Birgit Habedank Tags: Case Report Source Type: research

Visceral adiposity, muscle composition, and exercise tolerance in heart failure with preserved ejection fraction
AbstractAimsVisceral adipose tissue (AT) promotes inflammation and may be associated with disease progression in heart failure with preserved ejection fraction (HFpEF). We characterized regional AT distribution in HFpEF patients and controls and analysed associations with co ‐morbidities and exercise tolerance.Methods and resultsMagnetic resonance imaging was performed to quantify epicardial, liver, abdominal, and thigh skeletal muscle AT. We assessed New York Heart Association (NYHA) class, 6  min walk distance, and global well‐being score. Multivariable linear regression models adjusting for body surface area we...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Wendy Ying, Kavita Sharma, Lisa R. Yanek, Dhananjay Vaidya, Michael Sch är, Michael Markl, Vinita Subramanya, Sahar Soleimani, Pamela Ouyang, Erin D. Michos, Sanjiv J. Shah, Allison G. Hays Tags: Original Research Article Source Type: research

A mid ‐ventricular variant of Takotsubo syndrome: was it triggered by insular cortex damage?
We report the case of a 79 ‐year‐old female diagnosed with a mid‐ventricular variant of TTS concomitant with right IC ischaemic stroke. After 12 h of hospitalization, she experienced a sudden collapse. Rapid cardiopulmonary resuscitation resulted in a return of spontaneous circulation. Subsequent left ventriculography revealed akinesis in the mid‐portion of the left ventricle with vigorous contraction of the basal and apex segment. Two weeks after admission, cardiac ultrasound showed improved left ventricular contraction. Right IC ischaemia in this patient might have been associated with a dysregulation of the...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Ayano Osawa, Michiaki Nagai, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, Aya Yamane, Hiroshi Kobatake, Haruko Shiota, Naoki Ishibashi, Kazuki Takahashi, Carola Y. F örster Tags: Case Report Source Type: research

Long ‐term clinical and haemodynamic results after transcatheter annuloplasty for secondary mitral regurgitation
AbstractAimsThe study sought to investigate the long ‐term outcome after transcatheter mitral valve annuloplasty for secondary mitral regurgitation (MR).Methods and resultsConsecutive patients with symptomatic secondary MR undergoing transcatheter mitral valve annuloplasty with the Carillon device at Leipzig University Hospital between 2012 and 2018 were studied prospectively. Left ventricular (LV) function and MR severity were quantified by standardized echocardiography. 33 patients were included. Mean age was 75  ± 10 years, and 20 patients were women. A Society of Thoracic Surgeons score of 8.1&n...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Daniel Lavall, Julius Bruns, Tina Stegmann, Andreas Hagendorff, Stephan St öbe, Ulrich Laufs Tags: Original Research Article Source Type: research

The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study
This study aimed to investigate the role of platelet count, mean platelet volume (MPV) and platelet‐to‐leukocyte ratio, including platelet‐to‐monocyte and platelet‐to‐lymphocyte ratio with cardiac function, heart failure (HF) phenotypes and clinical outcome, worsening of HF.Methods and resultsUnivariate and multivariable linear and Cox regression analyses were used to investigate the associations between platelet indices, cardiac function and worsening of HF in 3250 subjects enrolled in the MyoVasc study. Higher MPV, lower platelet count, lower platelet ‐to‐leukocyte and platelet‐to‐monocyte ratios have...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Bianca Dahlen, Andreas Schulz, Sebastian G öbel, Sven‐Oliver Tröbs, Sören Schwuchow‐Thonke, Henri M. Spronk, Jürgen H. Prochaska, Natalie Arnold, Karl J. Lackner, Tommaso Gori, Hugo Cate, Thomas Münzel, Philipp S. Wild, Marina Panova Tags: Original Research Article Source Type: research

Combined associations of obesity and metabolic health with subclinical left ventricular dysfunctions: Danyang study
AbstractAimsThe association of strictly defined metabolic healthy obese (MHO) with subclinical cardiac function was unclear. Our study aims to examine the role of MHO in subclinical cardiac dysfunction in a Chinese population.Methods and resultsThe study subjects were recruited from Danyang from 2017 to 2019. Obesity was defined by body mass index (BMI) categories (normal weight, overweight and obesity). Metabolic health was strictly defined as having neither any of the guidelines recommended metabolic syndrome components nor insulin resistance. Thus, subjects were grouped by BMI categories and metabolic health status as s...
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Ye Wang, Junya Liang, Shasha Zheng, Anxia He, Chao Chen, Xixuan Zhao, Mulian Hua, Junyao Xu, Ziwen Zheng, Ming Liu Tags: Original Research Article Source Type: research

Sipuleucel ‐T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database
ConclusionsPatients with CV risk factors who are receiving sipuleucel ‐T may be at higher risk for congestive heart failure, myocardial ischemia, and supraventricular tachycardia. Electrocardiograms during weekly sipuleucel‐T infusions and left ventricular function monitoring with echocardiogram should be considered in these patients. Our findings are suggestive o f another rare presentation of T‐cell‐mediated CV toxicity with cancer immunotherapy. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Melissa Y.Y. Moey, Rahim A. Jiwani, Kotaro Takeda, Karyn Prenshaw, R. Wayne Kreeger, John Inzerillo, Darla K. Liles, C. Bogdan Marcu, B énédicte Lebrun‐Vignes, D. Lynn Morris, Sivakumar Ardhanari, Joe‐Elie Salem Tags: Short Communication Source Type: research

Dynamics of growth differentiation factor 15 in acute heart failure
ConclusionsGrowth differentiation factor 15 decreased during an acute HF hospitalization, but its variation had no prognostic implications. The knowledge of both admission and discharge GDF ‐15 added meaningful information to patients' risk stratification. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 3, 2021 Category: Cardiology Authors: Patr ícia Lourenço, Filipe M. Cunha, João Ferreira‐Coimbra, Isaac Barroso, João‐Tiago Guimarães, Paulo Bettencourt Tags: Original Research Article Source Type: research

Successful heart transplantation for COVID ‐19‐associated post‐infectious fulminant myocarditis
AbstractVarious clinical presentations of the 2019 coronavirus disease (COVID ‐19) have been described, including post‐infectious acute and fulminant myocarditis. Here, we describe the case of a young patient admitted for COVID‐19‐associated post‐infectious fulminant myocarditis. Despite optimal pharmacologic management, haemodynamic status worsened requiring suppor t by veno‐arterial extracorporeal membrane oxygenation. Emergent heart transplantation was required at Day 11 given the absence of cardiac function improvement. The diagnosis of post‐infectious COVID‐19‐associated myocarditis was made from bot...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Baptiste Gaudriot, Alexandre Mansour, Vincent Thibault, Mathieu Lederlin, Aur élie Cauchois, Bernard Lelong, James T. Ross, Guillaume Leurent, Jean‐Marc Tadié, Matthieu Revest, Jean‐Philippe Verhoye, Erwan Flecher, Nicolas Nesseler Tags: Case Report Source Type: research

High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction
ConclusionsHDL ‐C/CRP ratio was a useful marker for predicting all‐cause death and cardiac death and correlated with left ventricular diastolic function and right ventricular systolic function in HFpEF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Masamichi Yano, Masami Nishino, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Akihiro Tanaka, Yasuharu Matsunaga ‐Lee, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Takahisa Yama Tags: Original Research Article Source Type: research

Clinical impact of heart rate change in patients with acute heart failure in the early phase
ConclusionsA decrease in HR in the first 24  h after admission indicates better prognosis in patients with AHF, although the prognostic influence may differ between patients with sinus rhythm and those with atrial fibrillation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Shingo Kazama, Toru Kondo, Naoki Shibata, Hiroaki Hiraiwa, Itsumure Nishiyama, Toshiaki Kato, Akinori Sawamura, Yuki Kimura, Hideo Oishi, Tasuku Kuwayama, Ryota Morimoto, Takahiro Okumura, Kiyokazu Shimizu, Toyoaki Murohara Tags: Original Research Article Source Type: research

Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction
AbstractAimsFailure of right ventricular (RV) function worsens outcome in pulmonary hypertension (PH). The adaptation of RV contractility to afterload, the RV ‐pulmonary artery (PA) coupling, is defined by the ratio of RV end‐systolic to PA elastances (Ees/Ea). Using pressure–volume loop (PV‐L) technique we aimed to identify an Ees/Ea cut‐off predictive for overall survival and to assess hemodynamic and morphologic conditions for adapted RV func tion in secondary PH due to heart failure with reduced ejection fraction (HFREF).Methods and resultsThispost hoc analysis is based on 112 patients of the prospective ...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Alexander Schmei ßer, Thomas Rauwolf, Thomas Groscheck, Katharina Fischbach, Siegfried Kropf, Blerim Luani, Ivan Tanev, Michael Hansen, Saskia Meißler, Kerstin Schäfer, Paul Steendijk, Ruediger C. Braun‐Dullaeus Tags: Original Research Article Source Type: research

Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes
AbstractAimsHeart failure (HF) guidelines place patients into 3 discrete groups according to left ventricular ejection fraction (LVEF): reduced (
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Andreas B. Gevaert, Semra Tibebu, Mamas A. Mamas, Neal G. Ravindra, Shun Fu Lee, Tariq Ahmad, Dennis T. Ko, James L. Januzzi, Harriette G.C. Van Spall Tags: Original Research Article Source Type: research

Left ventricular remodelling and prognosis after discharge in new ‐onset acute heart failure with reduced ejection fraction
This study aimed to investigate the left ventricular (LV) remodelling and long ‐term prognosis of patients with new‐onset acute heart failure (HF) with reduced ejection fraction who were pharmacologically managed and survived until hospital discharge. We compared patients with ischaemic and non‐ischaemic aetiology.Methods and resultsThis cohort study consisted of 111 patients admitted with new ‐onset acute HF in the period 2008–2016 [62% non‐ischaemic aetiology, 48% supported by inotropes, vasopressors, or short‐term mechanical circulatory devices, and left ventricular ejection fraction (LVEF) at discharg...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Jan C. Berge, Maxime M. Vroegindewey, Jesse F. Veenis, Jasper J. Brugts, Kadir Caliskan, Olivier C. Manintveld, K. Martijn Akkerhuis, Eric Boersma, Jaap W. Deckers, Alina A. Constantinescu Tags: Original Research Article Source Type: research

A decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
ConclusionsHeart failure patients with a decrease in TRPG at 6  months after discharge from ADHF hospitalization had lower subsequent risk of all‐cause death and HF hospitalization than those without a decrease in TRPG, regardless of TRPG values. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Yuta Seko, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morin Tags: Original Research Article Source Type: research

Adaptive anti ‐myocardial immune response following hospitalization for acute heart failure
AbstractAimsIt has been hypothesized that cardiac decompensation accompanying acute heart failure (AHF) episodes generates a pro ‐inflammatory environment boosting an adaptive immune response against myocardial antigens, thus contributing to progression of heart failure (HF) and poor prognosis. We assessed the prevalence of anti‐myocardial autoantibodies (AMyA) as biomarkers reflecting adaptive immune responses in patient s admitted to the hospital for AHF, followed the change in AMyA titres for 6 months after discharge, and evaluated their prognostic utility.Methods and resultsAMyA were determined inn = ...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Caroline Morbach, Niklas Beyersdorf, Thomas Kerkau, Gustavo Ramos, Floran Sahiti, Judith Albert, Roland Jahns, Georg Ertl, Christiane E. Angermann, Stefan Frantz, Ulrich Hofmann, Stefan St örk Tags: Short Communication Source Type: research

A call for telehealth application for heart failure patients during the Coronavirus 2019 pandemic
(Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Mohammad Mostafa Ansari Ramandi, Hossein Yarmohammari, Nasim Naderi Tags: Letter to the Editor Source Type: research

Easy ‐to‐use preload stress echocardiography by using combined dynamic postural stress can identify high‐risk patients with heart failure with reduced ejection fraction
This study aimed to assess the haemodynamic characteristics of patients with HFrEF in response to non ‐invasive preload stress during dynamic postural alterations achieved by combining both semi‐sitting position and passive leg‐lifting and to evaluate whether combined postural stress could be used for risk stratification in these patients.Methods and resultsFor this study, 101 patients with HFrEF and 35 age ‐matched and sex‐matched healthy controls were prospectively recruited. After all standard echocardiographic measurements were obtained in the left decubitus position, all subjects underwent postural stress te...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Nao Shibata, Kensuke Katsumoto, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Yusuke Tanaka, Kentaro Yamashita, Shun Yokota, Makiko Suto, Kumiko Dokuni, Hidekazu Tanaka, Ken ‐ichi Hirata Tags: Original Research Article Source Type: research

Early follow ‐up at outpatient care after discharge improves long‐term heart failure readmission rate and prognosis
ConclusionsThe present study demonstrates that an early follow ‐up approach after discharge in CHF patients may improve the long‐term prognosis. These results may not depend on medication adjustment but rather on modifying patient factors early after discharge. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Ryuichi Matsukawa, Seigo Masuda, Hirohide Matsuura, Hiroka Nakashima, Hiroshi Ikuta, Kousuke Okabe, Arihide Okahara, Shunsuke Kawai, Masaki Tokutome, Tomoyuki Tobushi, Yasushi Mukai Tags: Original Research Article Source Type: research

Effects of echo ‐optimization of left ventricular assist devices on functional capacity, a randomized controlled trial
AbstractAimsAfter the implantation of a left ventricular assist device (LVAD), many patients continue to experience exercise intolerance. VAFRACT trial evaluates the additional benefit of LVAD echo ‐guided optimization (EO) on functional capacity (FC), measured by cardiopulmonary exercise test (CPET), and quality of life (QoL).Methods and resultsTwenty ‐seven patients were randomized in a 1:1 ratio to EO (EO group) vs. standard settings (CONTROL group) at least after 3 months from LVAD implant procedure. The optimal device speed was defined as the one that allows an intermittent aortic valve opening and a neutral ...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Marzia Lilliu, Francesco Onorati, Giovanni Battista Luciani, Giuseppe Faggian Tags: Original Research Article Source Type: research

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study
AbstractAimsThe increased incidence of heart failure in men suggests that endogenous sex hormones might play a role in the development of heart failure, but epidemiological data remain sparse. Here, we evaluated the predictive value of low testosterone levels on future heart failure in the large population ‐based FINRISK97 study.Methods and resultsBaseline serum testosterone concentrations were measured in 7855 subjects (3865 men and 3990 women) of the FINRISK97 study. During a median follow ‐up (FU) of 13.8 years, a total of 564 heart failure events were recorded. The age‐adjusted baseline testosterone levels d...
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Sarina Sch äfer, Muhammet Ali Aydin, Sebastian Appelbaum, Kari Kuulasmaa, Tarja Palosaari, Francisco Ojeda, Stefan Blankenberg, Pekka Jousilahti, Veikko Salomaa, Mahir Karakas Tags: Original Research Article Source Type: research

Identification of novel circulating microRNAs in advanced heart failure by next ‐generation sequencing
AbstractAimsRisk stratification in patients with advanced chronic heart failure (HF) is an unmet need. Circulating microRNA (miRNA) levels have been proposed as diagnostic and prognostic biomarkers in several diseases including HF. The aims of the present study were to characterize HF ‐specific miRNA expression profiles and to identify miRNAs with prognostic value in HF patients.Methods and resultsWe performed a global miRNome analysis using next ‐generation sequencing in the plasma of 30 advanced chronic HF patients and of matched healthy controls. A small subset of miRNAs was validated by real‐time PCR (P 
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Alessandro Galluzzo, Simona Gallo, Barbara Pardini, Giovanni Birolo, Piero Fariselli, Paolo Boretto, Annapia Vitacolonna, Caterina Peraldo ‐Neia, Martina Spilinga, Alessandra Volpe, Dario Celentani, Stefano Pidello, Alessandro Bonzano, Gius Tags: Original Research Article Source Type: research

Shear wave elastography to evaluate hepatic damage in heart failure
(Source: ESC Heart Failure)
Source: ESC Heart Failure - May 2, 2021 Category: Cardiology Authors: Pieter Bijl, Victoria Delgado, Jeroen J. Bax Tags: Editorial Source Type: research

Spot urine sodium in acute heart failure: differences in prognostic value on admission and discharge
AbstractAimsMost studies examined spot urine sodium's (sUNa+) prognostic utility during the early phase of acute heart failure (AHF) hospitalization. In AHF, sodium excretion is related to clinical status; therefore, we investigated the differences in the prognostic information of spot UNa+ throughout the course of hospitalization for AHF (admission vs. discharge).Methods and resultsThe study population were AHF patients (n = 172), who survived the index hospitalization. We compared the relationship between early (on admission, at 24 and 48 h) and discharge sUNa+ measurements with post ‐discharge study end...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Jan Biegus, Robert Zymli ński, Marat Fudim, Jeffrey Testani, Mateusz Sokolski, Dominik Marciniak, Barbara Ponikowska, Mateusz Guzik, Mateusz Garus, Szymon Urban, Piotr Ponikowski Tags: Short Communication Source Type: research

Parathormone levels add prognostic ability to N ‐terminal pro‐brain natriuretic peptide in stable coronary patients
AbstractAimsThere are controversial data on the ability of the components of mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor ‐23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value to other well‐known biomarkers.Methods and resultsIn 969 stable coronary patients, we determined plasma levels of all the aforementioned components of mineral metabolism with a complete set of clinical and biochemical variables, including N ‐terminal pro‐brain natriuretic peptide (NT‐proBNP), high‐sensitivity troponin I (hs‐Tn...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Carlos Guti érrez‐Landaluce, Álvaro Aceña, Ana Pello, Juan Martínez‐Milla, Óscar González‐Lorenzo, Nieves Tarín, Carmen Cristóbal, Luis M. Blanco‐Colio, José Luis Martín‐Ventura, Ana Huelmos, Marta López‐Castillo, Joaquí Tags: Original Research Article Source Type: research

Clinical phenotypes and prognosis of thyrotoxic heart failure and cardiomyopathy in patients hospitalized for acute heart failure
AbstractBackgroundWe sought to examine clinical characteristics and outcomes in patients hospitalized for acute heart failure (HF) and thyrotoxicosis.MethodsPatients with thyrotoxic HF were compared with age and gender ‐matched patients hospitalized for acute HF (controls). Thyr‐HF was defined by the Framingham criteria for HF and clinical hyperthyroidism. Thyrotoxic cardiomyopathy was defined as left ventricular ejection fraction (LVEF) 
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Weerapat Kositanurit, Veraprapas Kittipibul, Panudda Srichomkwun, Smonporn Boonyaratavej, Sarinya Puwanant Tags: Original Research Article Source Type: research

Impact of diastolic dysfunction on outcome in heart failure patients with mid ‐range or reduced ejection fraction
AbstractAimsThe role of diastolic dysfunction (DD) in prognostic evaluation in heart failure (HF) patients with impaired systolic function remains unclear. We investigated the impact of echocardiography ‐defined DD on survival in HF patients with mid‐range (HFmrEF, EF 41–49%) and reduced ejection fraction (HFrEF, EF 
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Dan Liu, Kai Hu, Kolja Lau, Tobias Kiwitz, Katharina Robitzkat, Clara Hammel, Bj örn Daniel Lengenfelder, Georg Ertl, Stefan Frantz, Peter Nordbeck Tags: Original Research Article Source Type: research

Prognostic value of lung ultrasound in patients hospitalized for heart disease irrespective of symptoms and ejection fraction
ConclusionsUltrasound B ‐lines can detect subclinical pulmonary interstitial oedema in patients thought to be free of congestion and provide useful information not only for the diagnosis but also for the prognosis in different cardiac conditions. Their added prognostic value among standard echocardiographic parameters is more robust in patients with HFpEF compared with HFrEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Luna Gargani, Nicola Riccardo Pugliese, Francesca Frassi, Paolo Frumento, Elisa Poggianti, Matteo Mazzola, Nicol ò De Biase, Patrizia Landi, Stefano Masi, Stefano Taddei, Peter S. Pang, Rosa Sicari Tags: Original Research Article Source Type: research

Five ‐year survival and use of hospital services following ICD and CRT implantation: comparing real‐world data with RCTs
ConclusionsClinical and cost ‐effectiveness assessments of ICD and CRT implantation are supported by real‐world data, although the prevalence of atrial fibrillation remains substantially higher than in the RCTs. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Alex Bottle, Puji Faitna, Paul Aylin, Martin R. Cowie Tags: Original Research Article Source Type: research

Derivation and validation of a two ‐variable index to predict 30‐day outcomes following heart failure hospitalization
ConclusionsThe LE index predicts 30 ‐day outcomes following HF hospitalization with similar or better performance than the more complex LACE index. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Tauben Averbuch, Shun Fu Lee, Mamas Andreas Mamas, Urun Erbas Oz, Richard Perez, Stuart James Connolly, Dennis Tien ‐Wei Ko, Harriette Gillian Christine Van Spall Tags: Original Research Article Source Type: research

Iron deficiency in heart failure
AbstractIron deficiency is a major heart failure co ‐morbidity present in about 50% of patients with stable heart failure irrespective of the left ventricular function. Along with compromise of daily activities, it also increases patient morbidity and mortality, which is independent of anaemia. Several trials have established parenteral iron supple mentation as an important complimentary therapy to improve patient well‐being and physical performance. Intravenous iron preparations, in the first‐line ferric carboxymaltose, demonstrated in previous clinical trials superior clinical effect in comparison with oral iron pr...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Goran Loncar, Danilo Obradovic, Holger Thiele, Stephan Haehling, Mitja Lainscak Tags: Review Source Type: research

Association between sacubitril/valsartan initiation and real ‐world health status trajectories over 18 months in heart failure with reduced ejection fraction
AbstractAimsImproving the health status (symptoms, function, and quality of life) of patients with heart failure with reduced ejection fraction (HFrEF) is a primary treatment goal. Angiotensin receptor neprilysin inhibitors (ARNI) improve short ‐term health status in clinical practice, but the sustainability of these improvements is unknown.Methods and resultsIn CHAMP ‐HF, a multicentre observational study of outpatients with HFrEF, patients initiated on ARNI were propensity score matched 1:2 to patients not using ARNI with Cox regression modelling time to ARNI initiation, adjusted for sociodemographic and clinical var...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Merrill Thomas, Yevgeniy Khariton, Gregg C. Fonarow, Suzanne V. Arnold, Larry Hill, Michael E. Nassif, Paul S. Chan, Javed Butler, Laine Thomas, Adam D. DeVore, Adrian F. Hernandez, Nancy M. Albert, J. Herbert Patterson, Fredonia B. Williams, Tags: Original Research Article Source Type: research

Wearable cardioverter ‐defibrillator: friend or foe in suspected myocarditis?
ConclusionsOur data suggest that myocarditis patients may benefit from WCD therapy. However, as our study is not powered for outcome, further randomized studies powered for the outcome morbidity and mortality are necessary. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Florian Blaschke, Philipp Lacour, Phi Long Dang, Abdul Shokor Parwani, Felix Hohendanner, Thula Walter, Karin Klingel, Uwe K ühl, Frank R. Heinzel, Mohammad Sherif, Leif‐Hendrik Boldt, Burkert Pieske, Carsten Tschöpe Tags: Short Communication Source Type: research

All ‐cause mortality predicted by peak oxygen uptake differs depending on spirometry pattern in patients with heart failure and reduced ejection fraction
AbstractAimsIn patients with heart failure and reduced ejection fraction (HFrEF), it remains unclear how exacerbated impairments in peak exercise oxygen uptake (V ̇O2peak) caused by coexistent obstructive or restrictive ventilatory defects affect mortality risk. We evaluated in patients with HFrEF, whether demonstrating either an obstructive or restrictive ‐patterned ventilatory defect on spirometry affects V̇O2peak to yield all ‐cause mortality risk predicted by V̇O2peak that is spirometry pattern specific.Methods and resultsWe retrospectively analysed resting spirometry and treadmill cardiopulmonary exercise testi...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Erik H. Van Iterson, Leslie Cho, Adriano Tonelli, J. Emanuel Finet, Luke J. Laffin Tags: Original Research Article Source Type: research

Corrigendum
(Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Tags: Corrigendum Source Type: research

Left ventricular geometry transition in hypertensive patients with heart failure with preserved ejection fraction
AbstractAimsHeart failure with preserved ejection fraction (HFpEF) develops in response to hypertensive left ventricular (LV) hypertrophy and is associated with increased cardiovascular events. Although the progression to systolic heart failure is a known consequence of LV hypertrophy and HFpEF, few data are available on the LV geometry change and frequency of deterioration to systolic dysfunction in this population.Methods and resultsWe evaluated the baseline and follow ‐up characteristics in 680 patients with LV hypertrophy and HFpEF in this prospective cohort study. The primary endpoint was 5 year all‐cause mor...
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Ping Guan, Jun Gu, Zhi ‐ping Song, Chang‐qian Wang, Wei Hu, Jun‐feng Zhang Tags: Original Research Article Source Type: research

Parvovirus B19 DNA detectable in hearts of patients with dilated cardiomyopathy, but absent or inactive in blood
ConclusionDuring recent B19V infection, viral DNA levels in blood were unaffected by endonuclease. In contrast, B19V DNA in blood in patients with DCM became undetectable or strongly reduced after application of endonuclease. Circulating viral DNA in this subset of patients with presumed parvovirus ‐associated DCM does not consist of intact viral particles. Viral replicative activity cannot be assumed from demonstrating B19V DNA in cardiac tissue or in blood in DCM patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Anne Russcher, Job Verdonschot, Marijke W.A. Molenaar ‐de Backer, Stephane R.B. Heymans, Aloys C.M. Kroes, Hans L. Zaaijer Tags: Original Research Article Source Type: research

Frequency, predictors, and prognosis of heart failure with improved left ventricular ejection fraction: a single ‐centre retrospective observational cohort study
AbstractAimsAn improved left ventricular ejection fraction (HFiEF) was observed across heart failure (HF) patients with a reduced or mid ‐range ejection fraction (HFrEF or HFmrEF, respectively). We postulated that HFiEF patients are clinically distinct from non‐HFiEF patients.Methods and resultsA total of 447 patients hospitalized due to a clinical diagnosis of HF (LVEF
Source: ESC Heart Failure - May 1, 2021 Category: Cardiology Authors: Qing Li, Yu Qiao, Jiong Tang, Yulong Guo, Ke Liu, Bangguo Yang, Yingqiu Zhou, Kai Yang, Shuqin Shen, Tao Guo, Jinrui Guo Tags: Original Research Article Source Type: research

Benefit of a wearable cardioverter defibrillator for detection and therapy of arrhythmias in patients with myocarditis
AbstractAimsMyocarditis may lead to malignant arrhythmias and sudden cardiac death. As of today, there are no reliable predictors to identify individuals at risk for these catastrophic events. The aim of this study was to evaluate if a wearable cardioverter defibrillator (WCD) may detect and treat such arrhythmias adequately in the peracute setting of myocarditis.Methods and resultsIn this observational, retrospective, single centre study, we reviewed patients presenting to the Charit é Hospital from 2009 to 2017, who were provided with a WCD for the diagnosis of myocarditis with reduced ejection fraction (
Source: ESC Heart Failure - April 22, 2021 Category: Cardiology Authors: Verena Tscholl, Dennis Wielander, Felicitas Kelch, Andrea Stroux, Philipp Attanasio, Carsten Tsch öpe, Ulf Landmesser, Mattias Roser, Martin Huemer, Bettina Heidecker, Patrick Nagel Tags: Original Research Article Source Type: research

Rationale and design of the AMULET study: A new Model of telemedical care in patients with heart failure
ConclusionsThe AMULET trial will provide a prospective assessment of the effect of comprehensive ambulatory intervention, based on telemedicine and haemodynamically guided therapy, on mortality and readmissions in HF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 22, 2021 Category: Cardiology Authors: Pawe ł Krzesiński, Janusz Siebert, Ewa Anita Jankowska, Waldemar Banasiak, Katarzyna Piotrowicz, Adam Stańczyk, Agata Galas, Andrzej Walczak, Piotr Murawski, Paweł Chrom, Piotr Gutknecht, Paweł Siwołowski, Piotr Ponikowski, Grzegorz Gie Tags: Study Design Source Type: research

Prognostic impact of hospital ‐acquired disability in elderly patients with heart failure
AbstractAimsFunctional decline is associated with worse outcomes in patients with elderly heart failure (HF), but little is known about the prognostic impact of hospital ‐acquired disability (HAD) during hospital stay after acute HF. The present study examines the prognostic significance of HAD in the prediction of all‐cause mortality in elderly patients who admitted for acute HF.Methods and resultsThis retrospective study was performed in 1941 elderly patients aged ≥65 years or older from the cardiovascular physiotherapy for acute HF patients in the Tokyo metropolitan area registry and excluded those who died ...
Source: ESC Heart Failure - April 10, 2021 Category: Cardiology Authors: Masakazu Saitoh, Yuta Takahashi, Daisuke Okamura, Mitsutoshi Akiho, Hidetoshi Suzuki, Naoki Noguchi, Yukito Yamaguchi, Kentaro Hori, Yuichi Adachi, Tetsuya Takahashi Tags: Original Research Article Source Type: research

Association of anaemia and all ‐cause mortality in patients with ischaemic heart failure varies by renal function status
AbstractAimsThe aims of the current study were to evaluate the association between anaemia and all ‐cause mortality according to chronic kidney disease (CKD) status and to explore at what level of haemoglobin concentration would the all‐cause mortality risk increase prominently among CKD and non‐CKD patients, respectively.Methods and resultsThis is a prospective cohort study, and 1559 patients with ischaemic heart failure (IHF) were included (mean age of 63.5  ± 11.0 years, 85.8% men) from December 2015 to June 2019. Patients were divided into the CKD (n = 481) and non‐CKD (n =&...
Source: ESC Heart Failure - April 10, 2021 Category: Cardiology Authors: Anping Cai, Zejia Wu, Lan Xu, Shuang Xia, Xuyu He, Ying Zhang, Jiyan Chen, Yingling Zhou, Liwen Li Tags: Original Research Article Source Type: research

Epidemiology of cardiogenic shock and cardiac arrest complicating non ‐ST‐segment elevation myocardial infarction: 18‐year US study
This study aims to evaluate the impact of the combination of cardiogenic shock (CS) and cardiac arrest (CA) complicating non ‐ST‐segment elevation myocardial infarction (NSTEMI).Methods and resultsAdult (>18  years) NSTEMI admissions using the National Inpatient Sample database (2000 to 2017) were stratified by the presence of CA and/or CS. Outcomes of interest included in‐hospital mortality, early coronary angiography, hospitalization costs, and length of stay. Of the 7 302 447 hospitalizations du e to NSTEMI, 147 795 (2.0%) had CS only, 155 522 (2.1%) had CA only, and 41 360 (0.6%) ...
Source: ESC Heart Failure - April 10, 2021 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Jacob C. Jentzer, Abhiram Prasad, Lindsey R. Sangaralingham, Kianoush Kashani, Nilay D. Shah, Shannon M. Dunlay Tags: Original Research Article Source Type: research

Novel dilated cardiomyopathy associated to Calreticulin and Myo7A gene mutation in Usher syndrome
We report a novel cardiomyopathy associated to Usher syndrome and related to combined mutation ofMYO7A andCalreticulin genes. A 37 ‐year‐old man with deafness and vision impairment because of retinitis pigmentosa since childhood and aMYO7A gene mutation suggesting Usher syndrome, developed a dilated cardiomyopathy with ventricular tachyarrhythmias and recurrent syncope. At magnetic resonance cardiomyopathy was characterized by left ventricular dilatation with hypo ‐contractility and mitral prolapse with valve regurgitation. At left ventricular endomyocardial biopsy, it was documented cardiomyocyte disconnection becau...
Source: ESC Heart Failure - April 9, 2021 Category: Cardiology Authors: Andrea Frustaci, Alessandro De Luca, Nicola Galea, Romina Verardo, Valentina Guida, Rosalba Carrozzo, Cristina Chimenti, Emanuela Frustaci, Luigi Sansone, Matteo Antonio Russo Tags: Case Report Source Type: research

Association between oral contraceptive use and incident heart failure
This study was performed to assess HF risk associated with OC use.Methods and resultsWe studied women participating in the Multi ‐Ethnic Study of Atherosclerosis with available data on OC use. Inverse probability of treatment weighting analyses were used to reduce baseline imbalances. Cox proportional hazards models were applied to evaluate the associations of OC use and HF risk. The primary analysis comprised a total of 35 94 participants [average age 62.10 (10.24) years]. During an average follow‐up of 12.45 (3.75) years, 138 incident HF occurred. In unadjusted Cox model, OC use was associated with a decreased risk o...
Source: ESC Heart Failure - April 9, 2021 Category: Cardiology Authors: Dongling Luo, Hezhi Li, Pengyuan Chen, Nanshan Xie, Ziyang Yang, Caojin Zhang Tags: Original Research Article Source Type: research

The potential role of plasma miR ‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy
ConclusionsThe present data suggest that plasma levels of miR ‐206 and miR‐155 are potential novel biomarkers for confirming the diagnosis of iCMP. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 8, 2021 Category: Cardiology Authors: Danilo Obradovic, Karl ‐Philipp Rommel, Stephan Blazek, Karin Klingel, Matthias Gutberlet, Christian Lücke, Petra Büttner, Holger Thiele, Volker Adams, Philipp Lurz, Fabian Emrich, Christian Besler Tags: Original Research Article Source Type: research

The other side of the coin: ‘centralization’ against ‘optimization’ in COVID‐19 pandemic
(Source: ESC Heart Failure)
Source: ESC Heart Failure - April 8, 2021 Category: Cardiology Authors: Nuccia Morici, Alice Sacco, Giovanni Forleo, Dario Brunelli, Giuseppe De Luca, Stefano Savonitto Tags: Letter to the Editor Source Type: research