Circulating miRNA in functional tricuspid regurgitation. Unveiling novel links to heart failure: A pilot study
ConclusionsCirculating miRNAs are novel diagnostic and prognostic biomarkers in severe FTR. The quantification of miR-186-5p, miR-30e-5p, and miR-152-3p held strong diagnostic value, and the quantification of miR-15a-5p and miR-92a-3p are independently associated with outcomes. The recognition of specific miRNAs offers a novel perspective for TR evaluation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Rocio Hinojar, Rafael Moreno ‐Gómez‐Toledano, Elisa Conde, Ariana Gonzalez‐Gomez, Ana García‐Martin, Paz González‐Portilla, Covadonga Fernández‐Golfín, Maria Laura García‐Bermejo, Carlos Zaragoza, Jose Luis Zamorano Tags: Original Article Source Type: research

Reply to: “CardioMEMS in HF patients: study confirms benefit in costs and QALYs, but does not measure QALYs”
(Source: ESC Heart Failure)
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Pau Codina, Francesc L ópez‐Seguí, Antoni Bayés‐Genís Tags: Reply Source Type: research

Representativeness of the PIONEER ‐HF and PARAGLIDE‐HF in patients hospitalized with acute heart failure
ConclusionsUsing trial criteria, only 31.3% of AHF patients were eligible for sacubitril –valsartan. Yet, non-eligible patients demonstrated similar outcomes to eligible patients, indicating a need for further evaluation of sacubitril–valsartan benefits in non-eligible AHF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Dong ‐Yi Chen, Chun‐Chi Chen, Cheng‐Hung Lee, Chi‐Nan Tseng, Shao‐Wei Chen, Shang‐Hung Chang, Tien‐Hsing Chen, Pao‐Hsien Chu, I‐Chang Hsieh, Ming‐Shien Wen, Ming‐Lung Tsai, Ming‐Jer Hsieh Tags: Original Article Source Type: research

Exercise limitation in hypertrophic cardiomyopathy: combined stress echocardiography and cardiopulmonary exercise test
ConclusionsBoth central and peripheral cardiovascular limitations are involved in exercise intolerance in HCM. Diastolic dysfunction seems to be the main driver for this limitation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Yonatan Erez, Eihab Ghantous, Aviel Shetrit, Ryan S. Zamanzadeh, David Zahler, Yoav Granot, Orly Ran Sapir, Michal Laufer Perl, Shmuel Banai, Yan Topilsky, Ofer Havakuk Tags: Original Article Source Type: research

Blunted cardiovascular responses to exercise by inhibiting afferent feedback via spinal cord stimulation in heart failure
AbstractThis case study investigated the impact of SCS on alterations in blood pressure during constant-load exercise in a female patient with heart failure. Three different SCS frequencies [No SCS (~0  Hz),Low SCS (~100  Hz), andHigh SCS (~1000  Hz)] with and without ischaemic stimulation of the legs (cuffs) were randomly applied during constant-load exercise. To determine cardiovascular and ventilatory responses to exercise following SCS frequencies, BP, heart rate (HR), and respiratory gas exchange were measured. This experiment was dup licated in visit 1 and visit 2 with a random application of SCS frequency order a...
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Chul ‐Ho Kim, Tim J. Lamer, Manda Keller‐Ross, Craig Stolen, Bruce D. Johnson Tags: Case Report Source Type: research

Predicting in ‐hospital mortality among patients admitted with a diagnosis of heart failure: a machine learning approach
AbstractExisting risk prediction models for hospitalized heart failure patients are limited. We identified patients hospitalized with a diagnosis of heart failure between 7 May 2013 and 26 April 2022 from a large academic, quaternary care medical centre (training cohort). Demographics, medical comorbidities, vitals, and labs were collected and were used to construct random forest machine learning models to predict in-hospital mortality. Models were compared with logistic regression, and to commonly used heart failure risk scores. The models were subsequently validated in patients hospitalized with a diagnosis of heart fail...
Source: ESC Heart Failure - April 19, 2024 Category: Cardiology Authors: Zina Jawadi, Rosemary He, Pratyaksh K. Srivastava, Gregg C. Fonarow, Suzan O. Khalil, Srikanth Krishnan, Eleazar Eskin, Jeffrey N. Chiang, Ali Nsair Tags: Review Source Type: research

Intramyocardial calcification in apical hypertrophic cardiomyopathy assessed using multimodality imaging: a case series
We report five cases of ApHCM, with evidence of intramyocardial calcification on echocardiogram. On cardiac magnetic imaging (MRI), a hypointense component at early gadolinium enhancement (EGE) sequences, compatible with calcium, and a deep layer, with hyperintensity at late gadolinium enhancement (LGE) sequences, referable to fibrosis, suggest an endomyocardial fibrosis (EMF) diagnosis. EMF pathologic hallmark is endocardium and myocardium scarring, evolving to dystrophic calcification. It is found only in few ApHCM patients. Our series is the largest one described until now. Analysing patients' history, coexistent inflam...
Source: ESC Heart Failure - April 18, 2024 Category: Cardiology Authors: Ilaria Radano, Barbara Mabritto, Stefania Luceri, Sergio Bongioanni, Francesco Maiellaro, Luca Zappia, Chiara Lario, Annalisa Macera, Stefano Cirillo, Alfredo Pizzuti, Rodolfo Citro, Gennaro Galasso, Giuseppe Musumeci Tags: Case Report Source Type: research

Prediction of cardiac worsening through to cardiogenic shock in patients with acute heart failure
ConclusionsHalf of patients admitted with AHF experience WHF or new-onset CS. Chronic kidney disease, tricuspid valve regurgitation, and elevated pro-adrenomedullin concentrations predict these events. They could potentially serve as early warning signs for further deterioration in AHF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 18, 2024 Category: Cardiology Authors: Benedikt N. Beer, Caroline Kellner, Jonas Sundermeyer, Lisa Besch, Angela Dettling, Paulus Kirchhof, Stefan Blankenberg, Christina Magnussen, Benedikt Schrage Tags: Original Article Source Type: research

Machine learning ‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy
ConclusionsOur study revealed a number of hub genes and novel pathways to provide potential targets for the treatment of HCM. A stable model was developed, providing an efficient tool for the diagnosis of HCM. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 17, 2024 Category: Cardiology Authors: Shutong Liu, Peiyu Yuan, Youyang Zheng, Chunguang Guo, Yuqing Ren, Siyuan Weng, Yuyuan Zhang, Long Liu, Zhe Xing, Libo Wang, Xinwei Han Tags: Original Article Source Type: research

Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT ‐HF trial
ConclusionsThe ALIMENT-HF trial will evaluate the tolerance, efficacy, and safety of high-calorie and high-protein-rich ONS in older outpatients with HF co-morbid with malnutrition and anorexia and will provide insightful information for future randomized controlled trials. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 17, 2024 Category: Cardiology Authors: Yudai Fujimoto, Taishi Dotare, Emi Maekawa, Kentaro Kamiya, Takeshi Kitai, Koichiro Kuwahara, Teruyasu Sugano, Masaaki Konishi, Tomohito Ohtani, Yoko Sakamoto, Kentaro Jujo, Chiharu Noda, Junya Ako, Naotake Yanagisawa, Yuya Matsue Tags: Study Design Source Type: research

Left ventricular reverse remodelling as a promising strategy for resolving left ventricular thrombus
ConclusionsPatients with LVRR experience higher incidence of LVT resolution and have lower risk of embolic events, highlighting the significance of identifying and mitigating risk factors that contribute to abnormal LV function and structure in management of patients with LVT. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 17, 2024 Category: Cardiology Authors: Xuefu Chen, Xinxin Zhang, Yahui Yang, Yuxi Sun, Jinping Si, Shufen Jiang, Yuze Hu, Zijie Ding, Yunlong Xia, Yanwei Chen, Ying Liu Tags: Original Article Source Type: research

Age ‐stratified profiles and outcomes of patients with heart failure with preserved ejection fraction
ConclusionsYounger HFpEF patients ( ≤64 years) exhibit a male predominance, elevated BMI, and poorly controlled diabetes, highlighting the importance of glycaemic control in reducing SCD risk. Older HFpEF patients (≥65 years) are more likely to be female, with multiple comorbidities linked to an increased risk of HF-related mort ality. These findings underscore the need for physicians to recognize age-related, distinct HFpEF phenotypes for personalized patient management. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 17, 2024 Category: Cardiology Authors: Shinsuke Yamanaka, Kotaro Nochioka, Hideka Hayashi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Satoshi Yasuda, Hiroaki Shimokawa, on behalf of the CHART ‐2 Investigators Tags: Original Article Source Type: research

Missed opportunities in heart failure diagnosis and management: study of an urban UK population
ConclusionsLow survival rates were observed across all HF groups, along with suboptimal rates of NP testing and specialist assessments. These findings suggest missed opportunities for timely and accurate HF diagnosis, a pivotal first step in improving outcomes for HF patients. Addressing these gaps in diagnosis and management is urgently needed. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 17, 2024 Category: Cardiology Authors: Sylwia Migas, Michelle Louise Ellis, Bozydar Wrona, Elena Rivero Sanz, Jack Brownrigg, Otto Strauss, Fozia Zahir Ahmed Tags: Original Article Source Type: research

Ca2+/calmodulin ‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak
ConclusionsS2814 phosphoresistance of RyR2 prevents the CaMKII-dependent SR Ca2+ leak induction but does not prevent the cardiomyopathic phenotype caused by enhanced CaMKII δC activity. Our data indicate that additional mechanisms—independent of SR Ca2+ leak —are critical for the maladaptive effects of chronically increased CaMKIIδC activity with respect to heart failure. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 15, 2024 Category: Cardiology Authors: Matthias Dewenter, Tilmann Seitz, Julia H. Steinbrecher, B. Daan Westenbrink, Haiyun Ling, Stephan E. Lehnart, Xander H.T. Wehrens, Johannes Backs, Joan Heller Brown, Lars S. Maier, Stefan Neef Tags: Original Article Source Type: research

Genetic predisposition in chemotherapy ‐induced cardiomyopathy in a 65‐year‐old female with metastatic breast cancer
We present a case of a 65-year-old woman with breast cancer who developed recurrent CTRCD following low-dose chemotherapy, despite lacking conventional cardiovascular risk factors. Her medical history included anthracycline-associated cardiomyopathy, and her condition deteriorated significantly after treatment with HER2-targeted therapies. Through the use of multimodal imaging, we detected severe left ventricular systolic dysfunction. Further investigation with genetic testing revealed a likely pathogenic variant in theTNNT2 gene, suggesting a genetic predisposition to CTRCD. This case implies the potential role of genetic...
Source: ESC Heart Failure - April 15, 2024 Category: Cardiology Authors: So ‐Young Lee, Hoon Seok Kim, Mi‐Hyang Jung, Suyon Chang, Myungshin Kim, Jong‐Chan Youn, Woo‐Baek Chung, Hae Ok Jung Tags: Case Report Source Type: research