Strong muscles, weak heart: testosterone ‐induced cardiomyopathy
AbstractExogenous anabolic androgen steroid use is associated with adverse cardiovascular outcomes. A 53 ‐year‐old bodybuilder presented with 3 months of exertional dyspnoea. Physical examination showed tachycardia and pan‐systolic murmur; an echocardiogram showed a left ventricular ejection fraction (EF) of 15%. Evaluations included normal coronary angiogram, iron panel and thyroid studies, a n egative viral panel (human immunodeficiency virus, Lyme disease, and hepatitis), and urine toxicology. He admitted to intramuscular anabolic steroid use; his testosterone level was 30 160.0 ng/dL (normal 280&nd...
Source: ESC Heart Failure - July 9, 2019 Category: Cardiology Authors: Sarah Doleeb, Ann Kratz, Monica Salter, Vinay Thohan Tags: Case Report Source Type: research

Perioperative mortality secondary to a pulmonary embolism during a surgical implantation of the Endo ‐Exo‐Prosthesis: a case report
We report on a 53 ‐year‐old female patient who suffered a perioperative death secondary to a pulmonary embolism (PE) during an implantation of Endo‐Exo‐Prosthesis. This is a retrospective review of medical case for a patient who had a previous above‐the‐knee amputation secondary to a failed previous arthr oplasty surgery. Our planned surgery was a stage 1 implantation of an Endo‐Exo‐Prosthesis, and it was performed under general anaesthesia. After 25 min from starting the surgical procedure, the patient sustained a cardiac arrest, and despite an active cardiopulmonary resuscitation for 50 min, the...
Source: ESC Heart Failure - July 9, 2019 Category: Cardiology Authors: Marcus Örgel, Horst‐Heinrich Aschoff, Christian Krettek, Tilman Graulich, Mohamed Omar, Afif Harb, Sulaiman Alazzawi Tags: Case Report Source Type: research

Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia
AbstractAimsThe aim of this study was to assess the burden of heart failure (HF) patients with/without iron deficiency/iron deficiency anaemia (ID/A) from the health insurance perspective.Methods and resultsWe conducted a retrospective claims database analysis using the Institut f ür angewandte Gesundheitsforschung Berlin research database. The study period spanned from 1 January 2012 to 31 December 2014. HF patients were identified by International Statistical Classification of Diseases and Related Health Problems, 10th revision, German Modification codes (I50.‐, I50.0‐ , I50.00, I50.01, I50.1‐, I50.11, I50.12,...
Source: ESC Heart Failure - July 9, 2019 Category: Cardiology Authors: Christian Jacob, Julia Altevers, Isabella Barck, Thomas Hardt, Sebastian Braun, Wolfgang Greiner Tags: Original Research Article Source Type: research

Evidence for a cardiac metabolic switch in patients with Hodgkin's lymphoma
AbstractAimsOur aim was to investigate the glucose uptake in cancer patients suffering from different entities, using18F ‐FDG positron emission tomography–computed tomography scans. We further aimed at identifying potential variables altering cardiac and skeletal muscle glucose metabolism.Methods and resultsIn a retrospective cohort study, we analysed cardiac and skeletal muscle18F ‐FDG uptake in onco‐positron emission tomography–computed tomography scans in adult patients suffering from Hodgkin's lymphoma, non‐Hodgkin's lymphoma, and non‐lymphatic cancer including patients suffering from thyroid canc...
Source: ESC Heart Failure - July 6, 2019 Category: Cardiology Authors: Markus B. Heckmann, Belal Totakhel, Daniel Finke, Markus S. Anker, Carsten M üller‐Tidow, Uwe Haberkorn, Hugo A. Katus, Lorenz H. Lehmann Tags: Original Research Article Source Type: research

Sex disparities in acute kidney injury complicating acute myocardial infarction with cardiogenic shock
AbstractAimsTo evaluate sex ‐specific disparities in acute kidney injury (AKI) complicating acute myocardial infarction‐related cardiogenic shock (AMI‐CS) in the United States.Methods and resultsThis was a retrospective cohort study from 2000 to 2014 from the National Inpatient Sample (20% sample of all hospitals in the United States). Patients>18  years admitted with a primary diagnosis of AMI and concomitant CS that developed AKI were included. The endpoints of interest were the prevalence, trends, and outcomes of men and women with AKI in AMI‐CS. Multivariable hierarchical logistic regression was used to...
Source: ESC Heart Failure - July 4, 2019 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Lina Ya'Qoub, Shannon M. Dunlay, Saarwaani Vallabhajosyula, Shashaank Vallabhajosyula, Pranathi R. Sundaragiri, Allan S. Jaffe, Bernard J. Gersh, Kianoush Kashani Tags: Short Communication Source Type: research

Alteration of medical therapy in patients with heart failure relative to change in symptom severity
AbstractIn this observational analysis from the Practice Innovation and Clinical Excellence Registry ®, we examined changes in guideline‐directed medical therapies relative to changes in symptom severity in ambulatory patients with heart failure with reduced ejection fraction, finding change in medication more often occurring when patients were changing their New York Heart Association symptom s everity, rather than during periods of stable symptoms. Additionally, despite being available for a year during the time of our analysis, the use of sacubitril/valsartan was extremely low, and most often added in the context ...
Source: ESC Heart Failure - July 3, 2019 Category: Cardiology Authors: Nasrien E. Ibrahim, Yang Song, Christopher P. Cannon, Gheorghe Doros, Patricia Russo, Angelo Ponirakis, Claire Alexanian, James L. Januzzi Tags: Short Communication Source Type: research

Heart failure with mid ‐range ejection fraction: characterization of patients from the PINNACLE Registry®
We examined data collected in the American College of Cardiology's National Cardiovascular Data Registry (NCDR) Practice Innovation and Clinical Excellence (PINNACLE) Registry ® for first HF patient visits between 1 May 2008 and 30 June 2016. Analysis was performed using ANOVAF‐tests (or Kruskal–Wallis tests for non‐normally distributed variables) for continuous parameters andχ2 tests for nominal covariates at the first diagnosed HF visit. Given the NCDR PINNACLE Registry ® is a US‐based registry, we opted to define HFmrEF as per the US guidelines, which define HFmrEF as LVEF 41–49% in contras...
Source: ESC Heart Failure - July 3, 2019 Category: Cardiology Authors: Nasrien E. Ibrahim, Yang Song, Christopher P. Cannon, Gheorghe Doros, Patricia Russo, Angelo Ponirakis, Claire Alexanian, James L. Januzzi Tags: Original Research Article Source Type: research

Case of isolated cardiac sarcoidosis diagnosed by newly developed abnormal uptake during serial follow ‐up fluorine‐18 fluorodeoxyglucose positron emission tomography
AbstractCardiac sarcoidosis (CS) causes lethal arrhythmia and heart failure and has a poor prognosis; therefore, early detection and early stage treatment are important. However, diagnosis of isolated CS may be difficult in some cases owing to the low sensitivity of myocardial biopsy. Herein, we describe the case of a patient with isolated CS, showing change from negative to positive fluorine ‐18 fluorodeoxyglucose (18F ‐FDG) positron emission tomography (PET) uptake results within 9 months. The patient showed rapid reduction in left ventricular systolic function with sustained ventricular tachycardia. The diagnos...
Source: ESC Heart Failure - July 2, 2019 Category: Cardiology Authors: Daichi Maeda, Yumiko Kanzaki, Shuichi Fujita, Maaya Inuyama, Shogo Takashima, Masatoshi Miyamura, Fumio Terasaki, Masaaki Hoshiga Tags: Case Report Source Type: research

Regional differences in heart failure hospitalizations, mortality, and readmissions in Slovenia 2004 –2012
ConclusionsSignificant regional differences in standardized HF hospitalization, mortality, and readmissions between the regions were seen. There were no differences in mortality and readmissions between statistical regions for individual similar patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 2, 2019 Category: Cardiology Authors: Daniel Omersa, Ivan Erzen, Mitja Lainscak, Jerneja Farkas Tags: Original Research Article Source Type: research

Health care utilization and mortality associated with heart failure ‐related admissions among cancer patients
AbstractAimsHeart failure (HF) outcomes continue to improve with widespread use of new therapies. Concurrently, cancer survival has dramatically improved. Yet whether cancer patients share similar strategies and outcomes of inpatient HF treatment to those without HF is unknown. We sought to assess the contemporary impacts of cancer on inpatient HF outcomes over time.Methods and resultsThe retrospective National Inpatient Sample (2003 –15) and National Readmissions Database (2013–14) registries were queried for adults admitted for HF and stratified for cancer status, excluding cases of metastatic disease. Tempor...
Source: ESC Heart Failure - July 2, 2019 Category: Cardiology Authors: Avirup Guha, Amit Kumar Dey, Merna Armanious, Katherine Dodd, Janice Bonsu, Hani Jneid, William Abraham, Michael G. Fradley, Daniel Addison Tags: Original Research Article Source Type: research

N ‐terminal pro brain natriuretic peptide eliminates the prognostic effect of atrial fibrillation in patients with chronic heart failure
AbstractAimsCo ‐morbid atrial fibrillation (AF) increases both mortality and N‐terminal pro brain natriuretic peptide (NT‐proBNP) concentrations in patients with chronic heart failure (CHF). It is unclear whether AF worsens prognosis independently from NT‐proBNP concentrations. If AF was an independent ris k factor, NT‐proBNP levels for outcome prediction would need to be adjusted in patients with AF. We aimed to analyse the influence of AF on the prognostic value of NT‐proBNP in patients with CHF.Methods and resultsA total of 2541 consecutive CHF patients with sinus rhythm (SR) or AF were identified in the out...
Source: ESC Heart Failure - July 1, 2019 Category: Cardiology Authors: Johannes Schnorbach, Hanna Fr öhlich, Tobias Täger, Anna Corletto, Hugo A. Katus, Lutz Frankenstein Tags: Original Research Article Source Type: research

Predictors of cardiac function in acute heart failure patients with mid ‐range ejection fraction: AURORA study
ConclusionsIn AHF patients with HFmrEF, we should evaluate for any ischaemic heart disease during hospitalization, especially in patients with non ‐enlarged left ventricular and non‐reduced serum Alb. AHF patients with HFmrEF who showed improvement in the EF tended to have better prognosis than those without improvement. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 21, 2019 Category: Cardiology Authors: Kyosuke Yanagawa, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Keisuke Yasumura, Akihiro Tanaka, Yasuharu Matsunaga ‐Lee, Daisuke Nakamura, Masamichi Yano, Masaki Yamato, Yasuyuki Egami, Ryu Shutta, Yasushi Sakata, Masami Nishino, Ju Tags: Original Research Article Source Type: research

Medical therapy doses at hospital discharge in patients with existing and de novo heart failure
ConclusionsIn a single ‐region experience of hospitalized HFrEF patients, a high proportion of eligible patients were discharged on ACE‐I/ARB or beta‐blocker. Less than half were prescribed MRAs, and few were prescribed ≥50% or target dosing of all medications. Further exploration into barriers to medication uptit ration, and improvement in processes of care, is needed. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 20, 2019 Category: Cardiology Authors: Michael J. Diamant, Sean A. Virani, Winston J. MacKenzie, Andrew Ignaszewski, Mustafa Toma, Nathaniel M. Hawkins Tags: Original Research Article Source Type: research

Corrigendum
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 19, 2019 Category: Cardiology Tags: Corrigendum Source Type: research

Prognostic impact of Framingham heart failure criteria in heart failure with preserved ejection fraction
This study aims to assess prognostic impact of Framingham criteria for heart failure (FC ‐HF) in patients with stable heart failure (HF) with preserved ejection fraction (HFpEF).Methods and resultsIn the prospective Karolinska ‐Rennes (KaRen) study, we assessed stable HFpEF patients after an acute HF episode. We evaluated associations between the four descriptive models of HFpEF and the composite endpoint of all‐cause mortality and HF hospitalization. The descriptive models were FC‐HF alone, FC‐HF + natriuretic peptides (NPs) according to the PARAGON trial, FC‐HF + NPs + echocardio...
Source: ESC Heart Failure - June 17, 2019 Category: Cardiology Authors: Ulrika L öfström, Camilla Hage, Gianluigi Savarese, Erwan Donal, Jean‐Claude Daubert, Lars H. Lund, Cecilia Linde Tags: Original Research Article Source Type: research

Blood urea nitrogen variation upon admission and at discharge in patients with heart failure
AbstractAimsHeart failure (HF) is one of the leading causes for hospitalization and mortality. After first admission with acute decompensated HF, some patients are in high risk for short ‐term and long‐term mortality. These patients should be identified, closely followed up, and treated. It has been observed that blood urea nitrogen (BUN) on admission is a predictive marker for short‐term mortality. Recently, it has been shown that higher BUN levels on discharge are also a bad prognostic predictor. However, the prognostic value of BUN alteration during hospital stay was not investigated; therefore, we aimed to invest...
Source: ESC Heart Failure - June 14, 2019 Category: Cardiology Authors: Johad Khoury, Fadel Bahouth, Yoav Stabholz, Adi Elias, Tanya Mashiach, Doron Aronson, Zaher S. Azzam Tags: Original Research Article Source Type: research

Sustained safe and effective anticoagulation using Edoxaban via percutaneous endoscopic gastrostomy
AbstractExtensive data support the safety of direct oral anticoagulants compared with vitamin K antagonists in patients with non ‐valvular atrial fibrillation, leading to a significantly increase in the use of these compounds in clinical practice. However, there is no compelling evidence supporting the use of direct oral anticoagulant in individuals who are intubated or have a percutaneous endoscopic gastrostomy (PEG): pati ents with several co‐morbidities are underrepresented in clinical trials, so the best long‐term strategy for anticoagulation is difficult to ascertain. The aim of the present report was to evaluat...
Source: ESC Heart Failure - June 11, 2019 Category: Cardiology Authors: Mattia Galli, Domenico D'Amario, Felicita Andreotti, Italo Porto, Rocco Vergallo, Mario Sabatelli, Stefano Lancellotti, Emiliana Meleo, Raimondo De Cristofaro, Filippo Crea Tags: Case Report Source Type: research

MitraClip improves cardiopulmonary exercise test in patients with systolic heart failure and functional mitral regurgitation
ConclusionsPercutaneous mitral valve repair with MitraClip was associated with an enhancement in cardiopulmonary performance in patients with systolic heart failure and secondary MR. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 11, 2019 Category: Cardiology Authors: Tom ás Benito‐González, Rodrigo Estévez‐Loureiro, Carmen Garrote‐Coloma, Ignacio Iglesias Garriz, Javier Gualis, Laura Álvarez‐Roy, Miguel Rodriguez‐Santamarta, Armando Pérez de Prado, Felipe Fernández‐Vázquez Tags: Short Communication Source Type: research

The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population
ConclusionsOur metabolomic profiling of three community ‐based cohorts study identified associations of circulating levels of the haem breakdown product urobilin, and sphingomyelin (30:1), a cell membrane component involved in signal transduction and apoptosis, with incident heart failure. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 30, 2019 Category: Cardiology Authors: Markus Stenemo, Andrea Ganna, Samira Salihovic, Christoph Nowak, Johan Sundstr öm, Vilmantas Giedraitis, Corey D. Broeckling, Jessica E. Prenni, Per Svensson, Patrik K.E. Magnusson, Lars Lind, Erik Ingelsson, Johan Ärnlöv, Tove Fall Tags: Original Research Article Source Type: research

Effect of ferric carboxymaltose on calculated plasma volume status and clinical congestion: a FAIR ‐HF substudy
ConclusionsIntravenous iron therapy with FCM is associated with early reductions in PVS and weight, implying that decongestion might be one mechanism via which iron repletion aids CHF patients. Calculated PVS is of prognostic utility in this cohort. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 30, 2019 Category: Cardiology Authors: Darlington O. Okonko, Fadi Jouhra, Huda Abu ‐Own, Gerasimos Filippatos, Josep Comin Colet, Chainey Suki, Claudio Mori, Piotr Ponikowski, Stefan D. Anker, for the FAIR‐HF Investigators Tags: Original Research Article Source Type: research

Hydralazine and nitrates in the treatment of heart failure with reduced ejection fraction
AbstractHydralazine and nitrate combination was the first treatment that showed improved survival of patients with heart failure with reduced left ventricular ejection fraction (HFREF) in the Vasodilator Heart Failure Trial (V ‐HeFT trial) in 1986. This showed a 34% reduction of mortality at 2 years of follow‐up in patients with advanced heart failure (New York Heart Association Class IV). The angiotensin‐converting enzyme inhibitor (ACEi), beta‐blockers, mineralocorticoid receptor antagonists, and most recently sacubitril–valsartan have superseded the combination of hydralazine and nitrates. However, th...
Source: ESC Heart Failure - May 22, 2019 Category: Cardiology Authors: Abdallah Al ‐Mohammad Tags: Perspective Source Type: research

Causes and consequences of cardiac fibrosis in patients referred for surgical aortic valve replacement
AbstractAimsCardiac fibrosis is associated with left ventricular (LV) remodelling and contractile dysfunction in aortic stenosis (AS). The fibrotic process in this condition is still unclear. The aim of this study was to determine the role of both local and systemic inflammation as underlying mechanisms of LV fibrosis and contractile dysfunction. The diagnostic values of 2D ‐strain echocardiography and serum biomarkers in the evaluation of cardiac fibrosis in this condition were assessed through correlation analyses.Methods and resultsPatients with AS referred for surgical valve replacement were prospectively and consecu...
Source: ESC Heart Failure - May 21, 2019 Category: Cardiology Authors: Arnault Galat, Aziz Guellich, Diane Bodez, Larissa Lipskaia, St éphane Moutereau, Eric Bergoend, Sophie Hüe, Julien Ternacle, Dania Mohty, Jean‐Luc Monin, Geneviève Derumeaux, Costin Radu, Thibaud Damy Tags: Original Research Article Source Type: research

Prominent ‘Y’ descent is an ominous sign of a poorer prognosis in heart failure with preserved ejection fraction
AbstractAimsThe heterogeneity of heart failure with preserved ejection fraction (HFpEF) represents different pathophysiological paths by which individual patients develop heart failure. The deterioration mechanisms are considered to be mainly left ventricular diastolic dysfunction, right ventricular (RV) systolic function, and RV afterload. It is unclear whether RV distensibility affects the deterioration of HFpEF. Our study aimed to clarify whether impaired RV distensibility is associated with the deterioration of HFpEF.Methods and resultsWe retrospectively enrolled 322 patients with HFpEF and examined their echocardiogra...
Source: ESC Heart Failure - May 20, 2019 Category: Cardiology Authors: Daisuke Harada, Hidetsugu Asanoi, Takahisa Noto, Junya Takagawa Tags: Original Research Article Source Type: research

Post ‐pacemaker implant QRS duration and heart failure admission in patients with sick sinus syndrome and complete atrioventricular block
This study aims to compare the incidence of HF admission and pacing‐induced cardiomyopathy between patients with SSS and CAVB.Methods and resultsA total of 824 patients who received single ventricular or dual ‐chamber pacemaker implantation at our hospital between January 2003 and December 2012 were recruited for the study. Patients with HF, those without complete cardiac echocardiography, and those with significant coronary artery disease were excluded. Finally, 315 patients with SSS and 289 patients with CAVB were enrolled in this study. The CAVB group had a higher pacing percentage (39.37 ± 9.17% vs...
Source: ESC Heart Failure - May 20, 2019 Category: Cardiology Authors: Wei ‐Chieh Lee, Hsiu‐Yu Fang, Huang‐Chung Chen, Yung‐Lung Chen, Tzu‐Hsien Tsai, Kuo‐Li Pan, Yu‐Sheng Lin, Mien‐Cheng Chen Tags: Original Research Article Source Type: research

High vs. low oxygen therapy in patients with acute heart failure: HiLo ‐HF pilot trial
ConclusionsIn this study, no differences were observed in the primary or secondary outcomes for patients randomized to high vs. low SpO2 targets. Further RCTs with larger sample sizes are warranted to determine the efficacy and safety of oxygen therapy in patients with AHF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 17, 2019 Category: Cardiology Authors: Nariman Sepehrvand, Wendimagegn Alemayehu, Brian H. Rowe, Finlay A. McAlister, Sean Diepen, Michael Stickland, Justin A. Ezekowitz Tags: Original Research Article Source Type: research

Accuracy of Doppler blood pressure measurement in continuous ‐flow left ventricular assist device patients
This study assesses the accuracy of the Doppler opening pressure method compared with the gold standard arterial line method in CF‐VAD patients.Methods and resultsIn a longitudinal cohort of HeartMate II and HVAD patients, arterial line BP and simultaneously measured Doppler opening pressure were obtained. Overall correlation, agreement between Doppler opening pressure and arterial line mean vs. systolic pressure, and the effect of arterial pulsatility on the accuracy of Doppler opening pressure were analysed. A total of 1933 pairs of Doppler opening pressure and arterial line pressure readings within 1  min of each...
Source: ESC Heart Failure - May 17, 2019 Category: Cardiology Authors: Song Li, Jennifer A. Beckman, Nathan G. Welch, Jason Bjelkengren, Sofia Carolina Masri, Elina Minami, April Stempien ‐Otero, Wayne C. Levy, Kevin D. O'Brien, Shin Lin, Stephen D. Farris, Richard K. Cheng, Gregory Wood, Kevin Koomalsingh, J Tags: Original Research Article Source Type: research

Hyperbilirubinaemia after cardiac surgery: the point of no return
AbstractAimsThe occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post ‐operative heart failure is fairly common. We investigated the incidence, predictive value, and post‐operative outcome of hyperbilirubinaemia after cardiac surgery in an effort to identify potential risk factors and significance on clinical outcome.Methods and resultsBetween 2006 and 2016, 1272 (10.1%) out of 12  556 patients developed hyperbilirubinaemia, defined as bilirubin concentration>3  mg/dL, during post‐operative course at our institution. All patients who were operated using cardiopulmonar...
Source: ESC Heart Failure - May 16, 2019 Category: Cardiology Authors: Mina Farag, Gabor Veres, Gabor Szab ó, Arjang Ruhparwar, Matthias Karck, Rawa Arif Tags: Original Research Article Source Type: research

Impella CP use in patients with non ‐ischaemic cardiogenic shock
ConclusionsThese data suggest that temporary use of the Impella CP device might be a useful therapeutic option for bridge to recovery not only in ischaemic but also in non ‐ischaemic cardiogenic shock. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 16, 2019 Category: Cardiology Authors: Octavian Maniuc, Tim Salinger, Fabian Anders, Jonas M üntze, Dan Liu, Kai Hu, Georg Ertl, Stefan Frantz, Peter Nordbeck Tags: Short Communication Source Type: research

Age ‐specific diastolic dysfunction improves prediction of symptomatic heart failure by Stage B heart failure
AbstractAimsWe investigated whether addition of diastolic dysfunction (DD) and longitudinal strain (LS) to Stage B heart failure (SBHF) criteria (structural or systolic abnormality) improves prediction of symptomatic HF in participants of the SCReening Evaluation of the Evolution of New Heart Failure study, a self ‐selected population at increased cardiovascular disease risk recruited from members of a health insurance fund in Melbourne and Shepparton, Australia. Both American Society of Echocardiography and European Association of Cardiovascular Imaging (ASE/EACVI) criteria and age‐specific Atheroscleros is Risk in Co...
Source: ESC Heart Failure - May 15, 2019 Category: Cardiology Authors: Jennifer M. Coller, Fei Fei Gong, Michele McGrady, Michael V. Jelinek, Julian M. Castro, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Henry Krum, Christopher M. Reid, David L. Prior, Duncan J. Campbell Tags: Original Research Article Source Type: research

A per ‐protocol initiation of sacubitril/valsartan in an advanced heart failure disease management programme in the Middle East Gulf Region
ConclusionsInitiating sacubitril/valsartan through a defined protocol selects for appropriate candidates and guides starting dose and titration. Overall, significant success can be achieved in replacing ACEI or ARB by sacubitril/valsartan in symptomatic heart failure with reduced ejection fraction patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 14, 2019 Category: Cardiology Authors: Bassam Atallah, Ziad G. Sadik, Mohamed Hisham, Oussama Kalagieh, Iman Hamour, Guirgis Gabra, Mosaad El Banna, Medhat Soliman, Antoine Cherfan, Feras Bader Tags: Original Research Article Source Type: research

Corrigendum
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 7, 2019 Category: Cardiology Tags: Corrigendum Source Type: research

Health ‐related quality of life after extracorporeal membrane oxygenation: a single centre's experience
ConclusionsOur survey indicates an overall positive long ‐term HRQL outcome for our ECMO survivors. A subset reported problems with functioning and HRQL. Future research should focus on identification of the survivors at risk for poor recovery who may benefit from rehabilitation interventions. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 7, 2019 Category: Cardiology Authors: Marte Christine Ørbo, Sidsel Fredheim Karlsen, Ellinor Phillips Pedersen, Stig Eggen Hermansen, Per Bjørnerud Rønning, Kathrine Aas Nergaard, Torvind Næsheim, Truls Myrmel Tags: Original Research Article Source Type: research

Heart failure in Finland: clinical characteristics, mortality, and healthcare resource use
AbstractAimsThe aims of this study were to describe patient characteristics of the adult chronic heart failure (HF) population and to estimate the prevalence, incidence, healthcare resource utilization (HCRU), and mortality associated with HF in Southwest Finland.Methods and resultsThis was a retrospective biobank and clinical registry study. Adult patients with an HF diagnosis (International Statistical Classification of Diseases and Related Health Problems (ICD) code I50) during 2004 –2013 in secondary care were included in the study and compared with age‐matched and gender‐matched control patients without an I...
Source: ESC Heart Failure - May 3, 2019 Category: Cardiology Authors: Jenni Huusko, Samu Kurki, Iiro Toppila, Timo Purmonen, Mariann Lassenius, Elisabet Gullberg, Sara Bruce Wirta, Heikki Ukkonen Tags: Original Research Article Source Type: research

Issue Information
AbstractNo abstract is available for this article. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 29, 2019 Category: Cardiology Tags: Issue Information Source Type: research

Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Failure, Volume 6, Issue 3, Page 557-558, June 2019. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 29, 2019 Category: Cardiology Authors: Cristiane C.K. Mayerhofer, Ayodeji Awoyemi, Johannes R. Hov, Marius Tr øseid, Kaspar Broch Tags: Correspondence Source Type: research

Prognostic value of exercise myocardial deformation and haemodynamics in long ‐term heart‐transplanted patients
AbstractAimsThe study evaluated exercise left ventricular global longitudinal strain (LVGLS) and invasive haemodynamics for major adverse cardiac events (MACE) prediction in heart ‐transplanted (HTx) patients.Methods and resultsThe study comprised 74 stable consecutive HTx patients who were followed at the Department of Cardiology, Aarhus University Hospital, Denmark, from August 2013 to January 2017. All patients were transplanted a minimum of 12  months before study entry and were included at the time of their routine annual coronary angiography. A symptom‐limited haemodynamic exercise test with simultaneous ech...
Source: ESC Heart Failure - April 26, 2019 Category: Cardiology Authors: Tor Skibsted Clemmensen, Hans Eiskj ær, Brian Bridal Løgstrup, Kamilla Pernille Bjerre Valen, Søren Mellemkjær, Steen Hvitfeldt Poulsen Tags: Original Research Article Source Type: research

Learned helplessness reveals a population at risk for depressive ‐like behaviour after myocardial infarction in mice
ConclusionsThe LH paradigm uncovered a subtle predisposition to depressive ‐like behaviour after MI, whereas testing for anhedonia and despair was insufficient to show a behavioural shift in mice. Therefore, we suggest an accumulating risk profile and a multiple‐hits hypothesis regarding the pathogenesis of co‐morbid depression after MI. Symptoms of LH may present a marker of subclinical depression after MI, the impact of which remains to be investigated. The proposed sequence of behavioural testing enables the mechanistic dissection of cardio‐psychogenic signalling in the future. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 26, 2019 Category: Cardiology Authors: Bastian Bruns, Thomas Schmitz, Nathalie Diemert, Chrysovalandis Schwale, Stefanie Maria Werhahn, Friederike Weyrauther, Peter Gass, Miriam Annika Vogt, Hugo Katus, Wolfgang Herzog, Johannes Backs, Jobst ‐Hendrik Schultz Tags: Original Research Article Source Type: research

Clinical profiles in acute heart failure: an urgent need for a new approach
AbstractAcute heart failure (HF) is a major public health concern, responsible for>26 million hospitalizations per year worldwide. Many trials have investigated new therapeutic options for acute HF, with most revealing equivocal results. Successful innovations in therapy for acute HF have remained limited, and standard of care has remained largely unchanged over the past decade, suggesting the need for a new approach for therapeutic decision making and clinical trial design in acute HF. This manuscript focuses on one approach that could prove useful in the development and application of novel therapies: classification o...
Source: ESC Heart Failure - April 25, 2019 Category: Cardiology Authors: Brittany Chapman, Adam D. DeVore, Robert J. Mentz, Marco Metra Tags: Review Source Type: research

Budget impact of intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency in France
ConclusionsIron deficiency treatment with ferric carboxymaltose in systolic chronic heart failure patients results in an improvement of New York Heart Association class and thereby increases the well ‐being of the patients, while providing an overall cost saving for the French national health insurance. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 25, 2019 Category: Cardiology Authors: Sandrine Bourguignon, Mathilde Faller, Fran çois‐Olivier Champs, Hélène Moutier, Karine Levesque, Gilbert Caranhac, Alain Cohen‐Solal Tags: Original Research Article Source Type: research

Strain ‐encoded magnetic resonance: a method for the assessment of myocardial deformation
This study aims to assess the usefulness of strain ‐encoded magnetic resonance (SENC) for the quantification of myocardial deformation (‘strain’) in healthy volunteers and for the diagnostic workup of patients with different cardiovascular pathologies. SENC was initially described in the year 2001. Since then, the SENC sequence has undergone s everal technical developments, aiming at the detection of strain during single‐heartbeat acquisitions (fast‐SENC). Experimental and clinical studies that used SENC and fast‐SENC or compared SENC with conventional cine or tagged magnetic resonance in phantoms, anim...
Source: ESC Heart Failure - April 25, 2019 Category: Cardiology Authors: Grigorios Korosoglou, Sorin Giusca, Nina P. Hofmann, Amit R. Patel, Tomas Lapinskas, Burkert Pieske, Henning Steen, Hugo A. Katus, Sebastian Kelle Tags: Review Source Type: research

Corrigendum
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 25, 2019 Category: Cardiology Tags: Corrigendum Source Type: research

Identifying a low ‐flow phenotype in heart failure with preserved ejection fraction: a secondary analysis of the RELAX trial
AbstractAimsThe relationship between resting stroke volume (SV) and prognostic markers in heart failure with preserved ejection fraction (HFpEF) is not well established. We evaluated the association of SV index (SVI) at rest with exercise capacity and N ‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) in stable patients with HFpEF.Methods and resultsParticipants enrolled in the Phosphodiesterase ‐5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX) trial with available data on SVI by the Doppler method were included in this analysis (n = 185). A low‐flow...
Source: ESC Heart Failure - April 16, 2019 Category: Cardiology Authors: Kershaw V. Patel, Rina Mauricio, Justin L. Grodin, Colby Ayers, Gregg C. Fonarow, Jarett D. Berry, Ambarish Pandey Tags: Original Research Article Source Type: research

Diagnostic accuracy of left atrial remodelling and natriuretic peptide levels for preclinical heart failure
AbstractAimsLeft atrial (LA) remodelling is an important predictor of cardiovascular events of heart failure (HF) and atrial fibrillation. Data regarding diagnostic value of LA remodelling on diastolic dysfunction (DD) and preclinical HF remain largely unexplored.Methods and resultsWe assessed LA dimension (LAD) in 8368 consecutive asymptomatic Asians (mean age: 49.7, 38.9% women) and related such measure to updated American Society of Echocardiography (ASE) DD criteria and newly revised N ‐terminal pro‐brain natriuretic peptide (NT‐proBNP) cut‐off (≥125 pg/mL) and HF with preserved ejection fraction criter...
Source: ESC Heart Failure - April 16, 2019 Category: Cardiology Authors: Jui ‐Peng Tsai, Kuo‐Tzu Sung, Cheng‐Huang Su, Yau‐Huei Lai, Jen‐Yuan Kuo, Chun‐Ho Yun, Chih‐Hsuan Yen, Charles Jia‐Yin Hou, Tung‐Hsin Wu, Ming‐Cheng Peng, Ta‐Chuan Hung, Hung‐I Yeh, Chung‐Lieh Hung Tags: Original Research Article Source Type: research

Minimally invasive biventricular mechanical circulatory support with Impella pumps as a bridge to heart transplantation: a first ‐in‐the‐world case report
We report a patient with biventricular failure secondary to rapidly progressive cardiac sarcoidosis refractory to medical management who was bridged to OHT with Impell a 5.0 and Impella RP—temporary left and right ventricular assist devices, respectively. This is the first successful bridge to transplantation using these devices in biventricular heart failure and cardiogenic shock. We discuss considerations for using this strategy over veno‐arterial extracorpo real membrane oxygenation or surgically implanted assist devices in patients with cardiogenic shock and biventricular failure as a bridge to OHT. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 9, 2019 Category: Cardiology Authors: Kenneth Varian, Weining David Xu, Weiqin Lin, Shinya Unai, Michael Z. Tong, Edward Soltesz, Amar Krishnaswamy, Samir Kapadia, Scott Feitell, Mazen Hanna, Emer Joyce, Paul Schoenhagen, Randall C. Starling, David O. Taylor, Antonio L. Perez Tags: Case Report Source Type: research

Motivational interviewing can support physical activity in elderly patients with diastolic heart failure: results from a pilot study
ConclusionsThe results from this pilot study suggest that our MI intervention was well accepted by participants and deemed feasible. It also appears to be an effective treatment to increase and maintain physical activity and exercise capacity in patients suffering from HFpEF. Our findings need to be confirmed in a randomized clinical trial with larger and unselected patient cohorts. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 8, 2019 Category: Cardiology Authors: Anna Schertz, Birgit Herbeck Belnap, Mira ‐Lynn Chavanon, Frank Edelmann, Rolf Wachter, Christoph Herrmann‐Lingen Tags: Original Research Article Source Type: research

Abdominal skeletal muscle mass as a predictor of mortality in Japanese patients undergoing left ventricular assist device implantation
ConclusionsPreoperative muscle wasting was associated with a higher mortality in patients with LVAD. Assessment of the abdominal skeletal muscle area on CT prior to LVAD implantation can help predict mortality. (Source: ESC Heart Failure)
Source: ESC Heart Failure - March 30, 2019 Category: Cardiology Authors: Masaki Tsuji, Eisuke Amiya, Masaru Hatano, Daisuke Nitta, Hisataka Maki, Chie Bujo, Akihito Saito, Yumiko Hosoya, Shun Minatsuki, Toru Hara, Mariko Nemoto, Yukie Kagami, Miyoko Endo, Mitsutoshi Kimura, Osamu Kinoshita, Kan Nawata, Hiroyuki Tags: Original Research Article Source Type: research

Issue Information
AbstractNo abstract is available for this article. (Source: ESC Heart Failure)
Source: ESC Heart Failure - March 27, 2019 Category: Cardiology Tags: Issue Information Source Type: research

Bone marrow and plasma FGF ‐23 in heart failure patients: novel insights into the heart–bone axis
AbstractAimsFibroblast growth factor 23 (FGF ‐23) is known to be elevated in patients with congestive heart failure (CHF). As FGF‐23 is expressed in the bone but can also be expressed in the myocardium, the origin of serum FGF‐23 in CHF remains unclear. It is also unclear if FGF‐23 expressed in the bone is associated with outcome in CH F. The aim of the present study was to investigate FGF‐23 levels measured in bone marrow plasma (FGF‐23‐BM) and in peripheral blood (FGF‐23‐P) in CHF patients to gain further insights into the heart–bone axis of FGF‐23 expression. We also investigated possible assoc...
Source: ESC Heart Failure - March 25, 2019 Category: Cardiology Authors: Beatrice Jeinsen, Kateryna Sopova, Lars Palapies, David M. Leistner, Stephan Fichtlscherer, Florian H. Seeger, J örg Honold, Stefanie Dimmeler, Birgit Aßmus, Andreas M. Zeiher, Till Keller Tags: Original Research Article Source Type: research

A 79 ‐year‐old woman with atrial fibrillation and new onset of heart failure
AbstractAs an alternative to oral anticoagulation, percutaneous left atrial appendage (LAA) closure is an increasingly performed procedure to prevent arterial embolism in patients with non ‐valvular atrial fibrillation. Besides procedure‐related complications, residual leaks, device‐related thrombus formation, and dislocation of the LAA occluder have been observed during follow‐up. Heart failure as a consequence of interventional LAA closure has not been reported so far. This case report describes a 79‐year‐old lady with permanent non‐valvular atrial fibrillation presenting with New York Heart Association Cla...
Source: ESC Heart Failure - March 22, 2019 Category: Cardiology Authors: Birke Schneider, Dirk Nazarenus, Claudia St öllberger Tags: Case Report Source Type: research

Underuse of hydralazine and isosorbide dinitrate for heart failure in patients of African ancestry: a cross ‐European survey
AbstractAimsPopulation data indicate that one in 25 persons of African ancestry has heart failure, a condition with relatively high mortality of around 50% in 5  years. Combined hydralazine and isosorbide dinitrate added to conventional therapy in African ancestry patients with heart failure and reduced ejection fraction improves quality of life and reduces the rate of first hospitalization for heart failure by 33% and annual mortality by 43%. The objectiv es of this study were to quantify the use of this guideline‐recommended therapy in Europe and the potential effect of implementation gaps on mortality.Methods and...
Source: ESC Heart Failure - March 20, 2019 Category: Cardiology Authors: Lizzy M. Brewster Tags: Original Research Article Source Type: research