Heart failure associated with imported malaria: a nationwide Danish cohort study
ConclusionIndividuals with a history of imported malaria, specificallyP.  falciparum, may have an increased risk of incident HF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 27, 2021 Category: Cardiology Authors: Philip Brainin, Grimur H øgnason Mohr, Daniel Modin, Brian Claggett, Odilson M. Silvestre, Amil Shah, Lasse S. Vestergaard, Jens Ulrik Stæhr Jensen, Lars Hviid, Christian Torp‐Pedersen, Lars Køber, Scott Solomon, Morten Schou, Gunnar H. Tags: Original Research Article Source Type: research

Right coronary artery diastolic perfusion pressure on outcome of patients with left heart failure and pulmonary hypertension
AbstractAimsRight ventricle adaptation to prolonged exposure against pulmonary hypertension (PH) includes structural and functional abnormalities, translated into modifications of blood flow pattern through the right coronary artery. Given these changes, we investigate the relationship between right coronary artery diastolic perfusion pressure (RCDPP) and clinical outcome, in patients with PH secondary to left-sided heart failure (HF).Methods and resultsWe studied 108 HF patients who underwent right heart catheterization. PH was present in 75 (69.4%). Mean RCDPP was lower in patients with PH (59.4  ± 14.0&...
Source: ESC Heart Failure - July 23, 2021 Category: Cardiology Authors: Amir Hamud, Marc Brezins, Alexander Shturman, Adrian Abramovich, Robert Dragu Tags: Original Research Article Source Type: research

Use of novel non ‐invasive techniques and biomarkers to guide outpatient management of fluid overload and reduce hospital readmission: systematic review and meta‐analysis
ConclusionsAn effective AFMP is associated with improving readmission and mortality in HF. Our results encourage attainment of optimal volume status at discharge and prescription of optimal diuretic dose. Ongoing support to maintain euvolaemia and effective collaboration between healthcare teams, along with effective patient education and engagement, may help to reduce adverse outcomes in HF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 23, 2021 Category: Cardiology Authors: Georgios Zisis, Amera Halabi, Quan Huynh, Christopher Neil, Melinda Carrington, Thomas H. Marwick Tags: Original Research Article Source Type: research

Effects of intravenous furosemide plus small ‐volume hypertonic saline solutions on markers of heart failure
AbstractAimsWe sought to compare the effects of furosemide  + hypertonic saline solution (HSS) treatment in patients with acute decompensated heart failure in comparison with furosemide alone and the response in a compensated state after an acute saline load with regard to serum levels of heart failure biomarkers.Methods and resultsWe enrolled 141 patients with acute decompensated heart failure with reduced ejection fraction admitted to our Internal Medicine ward from March 2017 to November 2019. A total of 73 patients were randomized to treatment with i.v. high-dose furosemide plus HSS, whereas 68 patients were ...
Source: ESC Heart Failure - July 21, 2021 Category: Cardiology Authors: Antonino Tuttolomondo, Carlo Maida, Alessandra Casuccio, Domenico Di Raimondo, Roberto Fonte, Valerio Vassallo, Maria Grazia Puleo, Tiziana Di Chiara, Alba Mogavero, Alessandro Del Cuore, Mario Daidone, Antonella Ortello, Antonio Pinto Tags: Original Research Article Source Type: research

Feasibility of patient ‐performed lung ultrasound self‐exams (Patient‐PLUS) as a potential approach to telemedicine in heart failure
ConclusionsThis pilot study reports that training HF patients to perform a LUS self-exam is feasible, with reported high self-efficacy. This supports further investigation into a telemedicine model using LUS to reduce emergency department visits and hospitalizations associated with HF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 20, 2021 Category: Cardiology Authors: Alan T. Chiem, George W. Lim, Amir P. Tabibnia, Andrea S. Takemoto, Daniel M. Weingrow, Jacqueline E. Shibata Tags: Original Research Article Source Type: research

The effects of lower body compression on left ventricular rotational mechanics in lymphoedema (from the MAGYAR ‐Path Study)
AbstractAimsLower body half compression of bilateral secondary leg lymphoedema (LE) without relevant cardiac insufficiency gives rise to whether external leg compression may influence left ventricular (LV) function. Patients with LE were subjected to baseline two-dimensional transthoracic echocardiography (2DTTE) for general assessment then three-dimensional speckle-tracking echocardiography (3DSTE) before and 1  h after lower body half external compression for LV torsion analysis.Methods and resultsBaseline 2DTTE was performed in the cohort of 25 LE patients, and the results were compared with those of age- and gende...
Source: ESC Heart Failure - July 20, 2021 Category: Cardiology Authors: Attila Nemes, Árpád Kormányos, Péter Domsik, Anita Kalapos, Lajos Kemény, Győző Szolnoky Tags: Short Communication Source Type: research

A global longitudinal strain cut ‐off value to predict adverse outcomes in individuals with a normal ejection fraction
ConclusionsThere is a strong correlation between cardiac adverse events and GLS values in subjects with a normal LVEF. In our single-centre study, −20.0% was determined as a cut-off value to identify subjects at risk. A next step should be to integrate GLS values in a multi-parametric model. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 18, 2021 Category: Cardiology Authors: Job A.J. Verdonschot, Michiel T.H.M. Henkens, Ping Wang, Georg Schummers, Anne G. Raafs, Ingrid P.C. Krapels, Vanessa Empel, Stephane R.B. Heymans, Hans ‐Peter Brunner‐La Rocca, Christian Knackstedt Tags: Short Communication Source Type: research

Right ventricular hemodynamics and performance in relation to perfusion during first year after heart transplantation
AbstractAimsWe aim to evaluate changes in invasive haemodynamics, right ventricular (RV) function, and perfusion during the first year after heart transplantation (HTx) and to determine the relation between RV function and myocardial perfusion.Methods and resultsThirty patients were prospectively enrolled at the time of HTx. Right heart catheterization (RHC), comprehensive 2D and 3D echocardiography and cardiac biomarkers were performed at baseline ( ≤2 weeks after HTx) and at follow-up 1, 3, 6, and 12 months after HTx. At 12 months, HTx patients were subjected to an exercise stress test with assessment o...
Source: ESC Heart Failure - July 17, 2021 Category: Cardiology Authors: Tor Skibsted Clemmensen, Steen Hvitfeldt Poulsen, Brian Bridal L øgstrup, Kamilla Pernille Bjerre, Lars Poulsen Tolbod, Hendrik J. Harms, Jens Sörensen, Hans Eiskjær Tags: Original Research Article Source Type: research

A case series of cardiac amyloidosis patients supported by continuous ‐flow left ventricular assist device
(Source: ESC Heart Failure)
Source: ESC Heart Failure - July 16, 2021 Category: Cardiology Authors: Varinder K. Randhawa, Andrej Gabrovsek, Edward G. Soltesz, Michael Z.Y. Tong, Shinya Unai, Leway Chen, Maria M. Mountis, W.H. Wilson Tang, Randall C. Starling, Jerry D. Estep, Mazen Hanna Tags: Letter to the Editor Source Type: research

Heart failure and promotion of physical activity before and after cardiac rehabilitation (HF ‐aPProACH): a study protocol
ConclusionsHF-aPProACH will provide novel information on the effectiveness of remote PA stimulation and feedback before, during and after standard CR using a commercially available device to improve physical fitness in HFrEF patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 16, 2021 Category: Cardiology Authors: Marlou A.M. Limpens, Muhammed T. G ürgöze, Mattie J. Lenzen, Stefan Roest, Trudy Voortman, Maryam Kavousi, Nienke Hoeve, Madoka Sunamura, Iris Uijl, Peter J. Spek, Jasper J. Brugts, Olivier C. Manintveld, Arne S. IJpma, Eric Boersma Tags: Study Design Source Type: research

WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study
This study aimed to determine whether WBC count predicts heart failure (HF) requiring hospitalization as well as all-cause death, acute myocardial infarction (AMI) and stroke in patients with Type 2 diabetes mellitus and established CAD.MethodsWe conducted this retrospective registry study that enrolled consecutive patients with Type 2 diabetes mellitus and CAD based on coronary arteriography records and medical charts at 70 teaching hospitals in Japan from 2005 to 2015. A total of 7608 participants (28.2% women, mean age 68  ± 10 years) were eligible. In the cohort, the median (interquartile range) a...
Source: ESC Heart Failure - July 16, 2021 Category: Cardiology Authors: Atsuhiko Kawabe, Takanori Yasu, Takeshi Morimoto, Akihiro Tokushige, Shin ‐ichi Momomura, Kenichi Sakakura, Koichi Node, Taku Inoue, Shinichiro Ueda, The CHD Collaborative Investigators Tags: Original Research Article Source Type: research

Cardiac congestion assessed by natriuretic peptides oversimplifies the definition and treatment of heart failure
(Source: ESC Heart Failure)
Source: ESC Heart Failure - July 14, 2021 Category: Cardiology Authors: Alberto Palazzuoli, Wilfried Mullens Tags: Editorial Source Type: research

Standardized gait speed ratio in elderly patients with heart failure
AbstractAimsAlthough aging is strongly associated with both heart failure and a decline in gait speed, a definition of slowness incorporating an age-related decline has yet to be developed. We aimed to define an event-driven cut-off for the relative decline in gait speed against age-adjusted reference values derived from the general population and evaluate its prognostic implications.Methods and resultsStandardized gait speed (SGS) was defined as the median gait speed stratified by age, sex, and height in 3777 elderly (age  ≥ 65 years) individuals without a history of cardiovascular diseases (Tokyo Metrop...
Source: ESC Heart Failure - July 10, 2021 Category: Cardiology Authors: Tetsuya Ozawa, Masashi Yamashita, Satoshi Seino, Kentaro Kamiya, Nobuyuki Kagiyama, Masaaki Konishi, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Shin Tags: Original Research Article Source Type: research

Temporal change in inflammatory biomarkers and risk of cardiovascular events: the Multi ‐ethnic Study of Atherosclerosis
AbstractAimsLittle is known about the association of temporal changes in inflammatory biomarkers and the risk of death and cardiovascular diseases. We aimed to evaluate the association between temporal changes in C-reactive protein (CRP), fibrinogen, and interleukin-6 (IL-6) and risk of heart failure (HF), cardiovascular disease (CVD), and all-cause mortality in individuals without a history of prior CVD.Methods and resultsParticipants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort with repeated measures of inflammatory biomarkers and no CVD event prior to the second measure were included. Quantitative measur...
Source: ESC Heart Failure - July 9, 2021 Category: Cardiology Authors: Mahsima Shabani, Hooman Bakhshi, Mohammad R. Ostovaneh, Xiaoyang Ma, Colin O. Wu, Bharath Ambale ‐Venkatesh, Michael J. Blaha, Matthew A. Allison, Matthew J. Budoff, Mary Cushman, Russell P. Tracy, David M. Herrington, Moyses Szklo, Christo Tags: Original Research Article Source Type: research

The evidence for pharmacist care in outpatients with heart failure: a systematic review and meta ‐analysis
AbstractAimsPatients with heart failure (HF) have poor outcomes, including poor quality of life, and high morbidity and mortality. In addition, they have a high medication burden due to the multiple drug therapies now recommended by guidelines. Previous reviews, including studies in hospital settings, provided evidence that pharmacist care improves outcomes in patients with HF. Because most HF is managed outside of hospitals, we aimed to synthesize the evidence for pharmacist care in outpatients with HF.Methods and resultsWe conducted a systematic literature search in PubMed of randomized controlled trials (RCTs) and integ...
Source: ESC Heart Failure - July 9, 2021 Category: Cardiology Authors: Pia M. Schumacher, Nicolas Becker, Ross T. Tsuyuki, Nina Griese ‐Mammen, Sheri L. Koshman, Michael A. McDonald, Marcel Bouvy, Frans H. Rutten, Ulrich Laufs, Michael Böhm, Martin Schulz Tags: Original Research Article Source Type: research

The prognostic value of serial troponin measurements in patients admitted for COVID ‐19
AbstractAimsMyocardial injury (MI) in coronavirus disease-19 (COVID-19) is quite prevalent at admission and affects prognosis. Little is known about troponin trajectories and their prognostic role. We aimed to describe the early in-hospital evolution of MI and its prognostic impact.Methods and resultsWe performed an analysis from an Italian multicentre study enrolling COVID-19 patients, hospitalized from 1 March to 9 April 2020. MI was defined as increased troponin level. The first troponin was tested within 24  h from admission, the second one between 24 and 48 h. Elevated troponin was defined as values above th...
Source: ESC Heart Failure - July 8, 2021 Category: Cardiology Authors: Vincenzo Nuzzi, Marco Merlo, Claudia Specchia, Carlo Mario Lombardi, Valentina Carubelli, Annamaria Iorio, Riccardo Maria Inciardi, Antonio Bellasi, Claudia Canale, Rita Camporotondo, Francesco Catagnano, Laura Adelaide Dalla Vecchia, Stefano Tags: Original Research Article Source Type: research

Empagliflozin confers reno ‐protection in acute myocardial infarction and type 2 diabetes mellitus
AbstractAimsAlthough the reno-protective effects of sodium –glucose cotransporter 2 inhibitors are known in patients with heart failure or type 2 diabetes mellitus (T2DM), this effect has not been confirmed in patients with acute myocardial infarction (AMI).Methods and resultsThe prospective, multicentre, randomized, double-blind, placebo-controlled EMBODY trial investigated patients with AMI and T2DM in Japan. The eligible patients included adults aged 20  years or older, diagnosed with AMI and T2DM, and who could be discharged within 2–12 weeks after the onset of AMI. One hundred and five patients w...
Source: ESC Heart Failure - July 8, 2021 Category: Cardiology Authors: Kosuke Mozawa, Yoshiaki Kubota, Yu Hoshika, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu ‐ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Mitsunori Maruyama, Tags: Original Research Article Source Type: research

A systematic review of rehabilitation in chronic heart failure: evaluating the reporting of exercise interventions
AbstractA large body of research supports the use of exercise to improve symptoms, quality of life, and physical function in patients with chronic heart failure. Previous reviews have focused on reporting outcomes of exercise interventions such as cardiorespiratory fitness. However, none have critically examined exercise prescription. The aim of this review was to evaluate the reporting and application of exercise principles in randomised control trials of exercise training in patients with chronic heart failure. A systematic review of exercise intervention RCTs in patients with CHF, using the Consensus on Exercise Reporti...
Source: ESC Heart Failure - July 8, 2021 Category: Cardiology Authors: Amy E. Harwood, Sophie Russell, Nduka C. Okwose, Scott McGuire, Djordje G. Jakovljevic, Gordon McGregor Tags: Review Source Type: research

Integrins in cardiac hypertrophy: lessons learned from culture systems
AbstractHeart growth and pathological changes are accompanied by extracellular matrix-dependent alterations in integrins and integrin-associated proteins, suggesting their role in heart development and disease. Most of our knowledge on the involvement of integrins in heart pathology is provided by thein vivo experiments, including cardiac hypertrophy models. However,in vivo studies are limited by the complex organization of heart tissue and fail to discern cell types and particular integrins implicated in hypertrophic signalling. This problem is being addressed by isolated cardiomyocyte primary cultures, which have been su...
Source: ESC Heart Failure - July 7, 2021 Category: Cardiology Authors: Natalya Bildyug Tags: Review Source Type: research

Malignancy predicts short ‐term mortality in Takotsubo: insights from a meta‐analysis of 125 359 patients
(Source: ESC Heart Failure)
Source: ESC Heart Failure - July 6, 2021 Category: Cardiology Authors: Alicja Genc, Natasza Gilis ‐Malinowska, Piotr Kasprzyk, Aleksandra Gasecka, Adrian Perdyan, Justyna Kacperczyk, Marcin Fijalkowski, Marcin Gruchala, Lukasz Szarpak, Kamil Safiejko, Krzysztof J. Filipiak, Dagmara Hering, Milosz Jaguszewski Tags: Letter to the Editor Source Type: research

Sodium ‐glucose cotransporter 2 inhibitor effects on heart failure hospitalization and cardiac function: systematic review
ConclusionsSodium –glucose cotransporter 2 inhibitors reduce HHF regardless of T2DM status, and reversal of adverse left ventricular remodelling likely contributes to this efficacy. Hypothesis-driven mechanistic trials remain sparse, although numerous trials are planned or ongoing. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 5, 2021 Category: Cardiology Authors: Roy Rasalam, John J. Atherton, Gary Deed, Michael Molloy ‐Bland, Neale Cohen, Andrew Sindone Tags: Original Research Article Source Type: research

A comparison of non ‐invasive methods of measuring body composition in patients with heart failure: a report from SICA‐HF
AbstractBackgroundCachexia is common in patients with chronic heart failure and is associated with poor prognosis. How best to measure body composition is not clear.Methods and resultsWe characterized body composition in 120 patients with chronic heart failure: mean (SD) age 70 (10) years, left ventricular ejection fraction 44 (10) %, and median (Q1 –Q3) N-terminal pro B-type natriuretic peptide 845 (355–1368) ng/L. We measured body composition using dual-energy X-ray absorptiometry (DEXA) and a multi-frequency bioelectrical impedance analysis (BIA) device (Tanita BIA MC-180MA). Mean (SD) fat mass (FM) was 27.2...
Source: ESC Heart Failure - July 4, 2021 Category: Cardiology Authors: Parin Shah, Alexandra A.I. Abel, Vennela Boyalla, Pierpaolo Pellicori, Anna Kallvikbacka ‐Bennett, Shirley Sze, John G.F. Cleland, Andrew L. Clark Tags: Original Research Article Source Type: research

Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival
This study investigated the post-transplant outcomes of patients with complete RBBB (cRBBB)  ≤ 30 days after HTX.MethodsThis registry study analysed 639 patients receiving HTX at Heidelberg Heart Center between 1989 and 2019. Patients were stratified by diagnosis of cRBBB  ≤ 30 days after HTX. Analysis included recipient and donor data, medication, echocardiographic features, graft rejections, atrial fibrillation, heart rates, permanent pacemaker implantation and mortality after HTX including causes of death.ResultsOne hundred thirty-nine patients showed cRBBB  ≤ 30 day...
Source: ESC Heart Failure - July 2, 2021 Category: Cardiology Authors: Ann ‐Kathrin Rahm, Matthias Helmschrott, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Philipp Ehlermann, Michael M. Kreusser, Gregor Warnecke, Norbert Frey, Rasmus Rivinius Tags: Original Research Article Source Type: research

Abnormal P ‐wave terminal force in lead V1 is a marker for atrial electrical dysfunction but not structural remodelling
ConclusionsAbnormal PTFV1 is an independent predictor for impaired atrial function and for electrical but not for structural remodelling. PTFV1 may be a promising tool to evaluate patients for atrial cardiomyopathy and for risk of atrial fibrillation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 1, 2021 Category: Cardiology Authors: Simon Lebek, Michael Wester, Jan Pec, Florian Poschenrieder, Maria Tafelmeier, Christoph Fisser, Zdenek Provaznik, Simon Schopka, Kurt Debl, Christof Schmid, Stefan Buchner, Lars S. Maier, Michael Arzt, Stefan Wagner Tags: Original Research Article Source Type: research

Reaching consensus for unified medical language in Fontan care
ConclusionsWe propose the use of these definitions for clinical care, future research studies, registry development and clinical trials. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 30, 2021 Category: Cardiology Authors: Tarek Alsaied, Rahul H. Rathod, Jamil A. Aboulhosn, Werner Budts, Jeffrey B. Anderson, Helmut Baumgartner, David W. Brown, Rachael Cordina, Yves D'udekem, Salil Ginde, David J. Goldberg, Bryan H. Goldstein, Adam M. Lubert, Erwin Oechslin, Al Tags: Original Research Article Source Type: research

Long ‐term administration of intravenous inotropes in advanced heart failure
ConclusionIn-hospital continuous parenteral inotropic therapy may serve as a temporary pharmacological bridge to HTx in patients with advanced HF that are actively listed to HTx with good reply in terms of prognosis and perfusion markers. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 30, 2021 Category: Cardiology Authors: Piero Gentile, Claudia Marini, Enrico Ammirati, Enrico Perna, Gianluigi Saponara, Andrea Garascia, Luciana D'Angelo, Alessandro Verde, Grazia Foti, Gabriella Masciocco, Maria Frigerio, Manlio Cipriani Tags: Short Communication Source Type: research

Impact of admission hyperglycaemia on clinical outcomes in non ‐diabetic heart failure with preserved ejection fraction
This study was designed to evaluate the relationship between admission hyperglycaemia and clinical outcome in HFpEF patients, especially in non-diabetic patients.Methods and resultsWe enrolled 486 non-diabetic HFpEF (left ventricular ejection fraction ≥50%) patients hospitalized due to acute decompensated heart failure from the PURSUIT-HFpEF registry, a prospective, multicentre observational study. We divided non-diabetic patients into two groups, an admission hyperglycaemia group whose blood glucose on admission was ≥7.0 mmol/L (148 patient s) and a normoglycaemic group whose blood glucose on admission was
Source: ESC Heart Failure - June 30, 2021 Category: Cardiology Authors: Masamichi Yano, Masami Nishino, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Akihiro Tanaka, Yasuharu Matsunaga ‐Lee, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Takahisa Yama Tags: Original Research Article Source Type: research

Impact of beta ‐blocker use on the long‐term outcomes of heart failure patients with chronic obstructive pulmonary disease
AbstractAimsThe number of patients with both chronic obstructive pulmonary disease (COPD) and heart failure (HF) is increasing in Asia, and these conditions often coexist. We previously revealed a tendency of beta-blocker underuse among patients with HF with reduced ejection fraction (HFrEF) and COPD in Asian countries other than Japan. Here, we evaluated the impact of cardio-selective beta-blocker use on the long-term outcomes of patients with HF and COPD.Methods and resultsAmong the 5232 patients with HFrEF (left ventricular ejection fraction of
Source: ESC Heart Failure - June 30, 2021 Category: Cardiology Authors: Yoshiaki Kubota, Wan Ting Tay, Tiew ‐Hwa Katherine Teng, Kuniya Asai, Takashi Noda, Kengo Kusano, Atsushi Suzuki, Nobuhisa Hagiwara, Shinji Hisatake, Takanori Ikeda, Ryobun Yasuoka, Takashi Kurita, Wataru Shimizu, ASIAN‐HF Executive Commi Tags: Original Research Article Source Type: research

Sex ‐specific differences in outcome and risk stratification of ventricular arrhythmias in implantable cardioverter defibrillator patients
AbstractAimsRisk stratification models of sudden cardiac death (SCD) are based on the assumption that risk factors of SCD affect risk to a similar extent in both sexes. The aim of the study is to evaluate differences in clinical outcomes between sexes and evaluate whether risk factors associated with appropriate device therapy (ADT) differ between men and women.Methods and resultsWe performed a cohort study of implantable cardioverter defibrillator (ICD) patients referred for primary or secondary prevention of SCD between 2009 and 2018. Multivariable Cox regression models for prediction of ADT were constructed for men and ...
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Anne ‐Lotte C.J. Lingen, Dominic A.M.J. Theuns, Mischa T. Rijnierse, Marthe A.J. Becker, Peter M. Ven, Albert C. Rossum, Vokko P. Halm, Michiel J.B. Kemme, Sing C. Yap, Cornelis P. Allaart Tags: Original Research Article Source Type: research

Temporal changes of cardiac acoustic biomarkers and cardiac function in acute decompensated heart failure
AbstractAimsRelationships between cardiac acoustic biomarkers (CABs) measured by acoustic cardiography and clinical outcomes have been reported in heart failure (HF) patients. However, no studies have investigated the temporal change of CABs and the corresponding changes in HF status. The purpose of this study was to assess whether the temporal changes of CABs in patients with acute decompensated heart failure (ADHF) reflect changes in cardiac function and status.Methods and resultsSixty ADHF patients were enrolled prospectively. CABs and echocardiography data were collected at admission, before discharge, and at the first...
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Jun Shitara, Takatoshi Kasai, Nobutaka Murata, Nobuhide Yamakawa, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Takao Kato, Shoko Suda, Yuya Matsue, Ryo Naito, Masaru Hiki, Hiroyuki Daida Tags: Original Research Article Source Type: research

Multiparameter diagnostic sensor measurements in heart failure patients presenting with SARS ‐CoV‐2 infection
ConclusionsMulti-sensor device diagnostics may provide early detection of Cov-19, distinguishable from worsening HF by an extreme and fast rise in respiratory rate along with no changes in S3. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Roy S. Gardner, Robert C. Capodilupo, Rezwan Ahmed, Craig M. Stolen, Qi An, Viktoria Averina, Adrian F. Hernandez, John P. Boehmer Tags: Original Research Article Source Type: research

Effects of inspiratory muscle training combined with aerobic exercise training on neurovascular control in chronic heart failure patients
ConclusionsIMT  + AET causes no additive effects on neurovascular control in patients with heart failure with reduced ejection fraction compared with AET alone. These findings may be, in part, because few patients had inspiratory muscle weakness. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Patricia F. Trevizan, Ligia M. Antunes ‐Correa, Denise M.L. Lobo, Patricia A. Oliveira, Dirceu R. Almeida, Maria Cristina D. Abduch, Wilson Mathias Junior, Ludhmila Abrahão Hajjar, Roberto Kalil Filho, Carlos Eduardo Negrão Tags: Original Research Article Source Type: research

Peripartum cardiomyopathy in Iraq: initial registry ‐based data and 6 month outcomes
ConclusionsAround half of our PPCM patients were diagnosed at post-partum period with impaired initial LVEF and GLS, and one-third had early LVEF recovery at 6  month follow-up, higher than that in the Middle East but lower than the globally reported figure in the EORP-PPCM registry. Limited use of bromocriptine might explain the later finding. The co-morbid diseases in our setting were hypertension and cholelithiasis. Interestingly, the comparable ratios of neonatal and maternal mortalities in our study to that of the EORP-PPCM registry were found less than the Middle East figures. Bromocriptine needs to be considere...
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Hasan Ali Farhan, Israa Fadhil Yaseen Tags: Original Research Article Source Type: research

Role of 3D echocardiography ‐determined atrial volumes in distinguishing between pre‐capillary and post‐capillary pulmonary hypertension
AbstractAimsThe current guidelines on pulmonary hypertension (PH) recommend the use of invasive examination for differentiating between left-sided heart disease-related (post-capillary) and pre-capillary PH. However, atrial sizes are considered markers of ventricular filling pressures. Therefore, we aimed to test the clinical applicability of atrial volumes measured by transthoracic three-dimensional echocardiography (3DE) in differentiating between pre-capillary and post-capillary PH.Methods and resultsSeventy-five consecutive patients with PH were prospectively examined with transthoracic 3DE. After less than 24  h,...
Source: ESC Heart Failure - June 29, 2021 Category: Cardiology Authors: Csaba Jenei, Rebeka K ádár, László Balogh, Attila Borbély, Ferenc Győry, Andrea Péter, Andrea Daragó, Zoltán Csanádi Tags: Original Research Article Source Type: research

Is 24/7 remote patient management in heart failure necessary? Results of the telemedical emergency service used in the TIM ‐HF and in the TIM‐HF2 trials
This study evaluates if a 24/7 telemedical emergency service is needed for the remote management of high-risk HF patients.Methods and resultsThe study included 1119 patients merged from the TIM-HF and TIM-HF2 trials [age 69  ± 11, 73% male, left ventricular ejection fraction 37% ± 13, 557 New York Heart Association (NYHA) II/562 NYHA III]. Patients received a 24/7 physician-guided emergency service provided by the telemedical centre (TMC) in addition to remote management within business hours. During emergency ca lls, patient status, symptoms, electronic patient record, and instant telemon...
Source: ESC Heart Failure - June 28, 2021 Category: Cardiology Authors: Sebastian Winkler, Kerstin Koehler, Sandra Prescher, Magdalena Koehler, Bridget ‐Anne Kirwan, Milos Tajsic, Friedrich Koehler Tags: Original Research Article Source Type: research

Heart failure is associated with an increased incidence of cancer diagnoses
AbstractAimsThe prognosis and quality of life of heart failure patients is determined to a significant extent by co-morbidities. New data suggest that heart failure may be associated with an increased incidence of cancer. The present retrospective study investigates this association in a large collective of outpatients with heart failure.Methods and resultsThis retrospective cohort study assessed the incidence of cancer in patients with an initial diagnosis of heart failure and a matched non-heart failure cohort in 1274 general practices in Germany between January 2000 and December 2018. The study is based on the Disease A...
Source: ESC Heart Failure - June 28, 2021 Category: Cardiology Authors: Christoph Roderburg, Sven H. Loosen, Julia K. Jahn, Julia G änsbacher, Tom Luedde, Karel Kostev, Mark Luedde Tags: Short Communication Source Type: research

A rare cause of effusive –constrictive pericarditis
AbstractEffusive –constrictive pericarditis (ECP) is an uncommon diagnosis, frequently missed due to its heterogeneous presentation, but a potentially reversible cause of heart failure. A 62-year-old Caucasian male presented with remittent right heart failure and mild–moderate pericardial effusion. Following an initial diagnosis of idiopathic pericarditis, indomethacin was started, but the patient shortly relapsed, presenting with severe pericardial effusion and signs of cardiac tamponade, requiring pericardiocentesis. ECP was diagnosed on cardiac catheterization. Cardiac computed tomography showed non-cal cifi...
Source: ESC Heart Failure - June 26, 2021 Category: Cardiology Authors: Andrea S. Giordani, Monica De Gaspari, Anna Baritussio, Stefania Rizzo, Elisa Carturan, Cristina Basso, Massimo Napodano, Luca Testolin, Renzo Marcolongo, Alida L.P. Caforio Tags: Case Report Source Type: research

Circulating microRNA ‐29‐5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease
In this study, we sought to compare heart failure patients with a diagnosis of either idiopathic dilated cardiomyopathy (DCM) or ischaemic heart disease (IHD), in the context of serum levels of certain miRs and also magnetic resonance imaging parameters of cardiac structure and function.Methods and resultsA total of 135 subjects were studied: 53 patients with DCM (age: 59  ± 12 years, mean ± SD), 34 patients with IHD (66 ± 9 years), and 48 controls (64 ± 5 years). The participants underwent baseline medical examination, blood sampling, and a...
Source: ESC Heart Failure - June 26, 2021 Category: Cardiology Authors: Martin Brundin, Dick W ågsäter, Urban Alehagen, Carl‐Johan Carlhäll Tags: Original Research Article Source Type: research

Factors that predict ventricular arrhythmias in the late phase after acute myocardial infarction
AbstractAimsLittle is known regarding factors that predict the occurrence of lethal ventricular arrhythmias (VAs) occurring after acute myocardial infarction (AMI). This observational cohort study aimed to identify factors that predicted lethal VAs during the late phase after AMI in patients with reduced left ventricular ejection fraction (LVEF).Methods and resultsData were collected from our AMI database regarding consecutive patients with an LVEF of ≤40% after AMI (January 2012 to July 2018). The ‘late phase’ was defined as ≥7 days after AMI onset, and the primary endpoint was defined as lethal VAs...
Source: ESC Heart Failure - June 26, 2021 Category: Cardiology Authors: Kan Saito, Yusuke Kondo, Masashi Takahashi, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi Tags: Original Research Article Source Type: research

Late phase of COVID ‐19 pandemic in General Cardiology. A position paper of the ESC Council for Cardiology Practice
AbstractCardiovascular (CV) engagement in coronavirus disease 2019 (COVID-19) is a huge determinant of prognosis during the acute phase of the disease. However, little is known about the potential chronic implications of the late phase of COVID-19 and about the appropriate approach to these patients. Heart failure, type 1 and type 2 myocardial infarction, arrhythmias, myocarditis, pulmonary fibrosis, and thrombosis have been shown to be related to severe acute respiratory syndrome coronavirus 2 infection, and a ‘long COVID-19’ illness has been recognized with fatigue, chest pain, and dyspnoea among the most fre...
Source: ESC Heart Failure - June 25, 2021 Category: Cardiology Authors: Dimitrios Richter, Luigina Guasti, Friedrich Koehler, Alessandro Squizzato, Stefano Nistri, Ruxandra Christodorescu, Francois Dievart, Giovanni Gaudio, Riccardo Asteggiano, Marc Ferrini Tags: ESC and HFA Paper Source Type: research

Telocytes ‐derived extracellular vesicles alleviate aortic valve calcification by carrying miR‐30b
ConclusionTC-EVs played a protective role in aortic valve calcification via the miR-30b/Runx2/Wnt/ β-catenin axis. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 24, 2021 Category: Cardiology Authors: Rong Yang, Yihu Tang, Xiaowen Chen, Yang Yang Tags: Original Research Article Source Type: research

Does pulmonary artery pulsatility index predict mortality in pulmonary arterial hypertension?
AbstractAimsPulmonary artery pulsatility index (PAPi), defined as [(pulmonary artery systolic pressure  − diastolic pulmonary artery pressure)/mean right atrial pressure], is a novel haemodynamic index that predicts right ventricular failure after myocardial infarction and left ventricular assist device implantation. We analysed if a low PAPi is associated with death in our 14 - ​year pulmonar y arterial hypertension (PAH) registry.MethodsConsecutive patients with newly diagnosed PAH and complete haemodynamic data were prospectively enrolled into our standing registry between January 2003 and Decembe...
Source: ESC Heart Failure - June 24, 2021 Category: Cardiology Authors: Yinghao Lim, Ting ‐Ting Low, Siew Pang Chan, Weiqin Lin, Ting Wei Teo, Jin‐Hao Justin Jang, Ivandito Kuntjoro, Edgar Lik‐Wui Tay, James Wei‐Luen Yip Tags: Original Research Article Source Type: research

Non ‐invasive home telemonitoring in patients with decompensated heart failure: a systematic review and meta‐analysis
AbstractWe planned this systematic review and meta-analysis to study an estimate of the effect of non-invasive home telemonitoring (TM) in the treatment of patients with recently decompensated heart failure (HF). A systematic literature search was conducted in the Medline, Cinahl, and Scopus databases to look for randomized controlled studies comparing TM with standard care in the treatment of patients with recently decompensated HF. The main outcomes of interest were all-cause hospitalizations and mortality. Eleven original articles met our eligibility criteria. The pooled estimate of the relative risk of all-cause hospit...
Source: ESC Heart Failure - June 24, 2021 Category: Cardiology Authors: Teemu E.I. Drews, Jari Laukkanen, Tuomo Nieminen Tags: Review Source Type: research

Prognostic significance of liver stiffness assessed by fibrosis ‐4 index in patients with heart failure
ConclusionsThe FIB4 index was a significant predictor for total cardiovascular events in HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 22, 2021 Category: Cardiology Authors: Masafumi Takae, Koichiro Fujisue, Eiichiro Yamamoto, Koichi Egashira, Takashi Komorita, Fumi Oike, Taiki Nishihara, Masahiro Yamamoto, Kyoko Hirakawa, Noriaki Tabata, Takanori Tokitsu, Kenshi Yamanaga, Daisuke Sueta, Shinsuke Hanatani, Taish Tags: Original Research Article Source Type: research

Identification of sex ‐specific biomarkers predicting new‐onset heart failure
This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF.Methods and resultsA matched case –control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF,n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH-ABC,& PROSPER), follow-up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O-link. To look for sex differences ...
Source: ESC Heart Failure - June 22, 2021 Category: Cardiology Authors: Anne Raafs, Job Verdonschot, Jo ão Pedro Ferreira, Ping Wang, Timothy Collier, Michiel Henkens, Jens Björkman, Alessandro Boccanelli, Andrew L. Clark, Christian Delles, Javier Diez, Arantxa González, Nicolas Girerd, J. Wouter Jukema, Flor Tags: Original Research Article Source Type: research

Sacubitril/valsartan improves cardiac function in Chinese patients with heart failure: a real ‐world study
AbstractAimsSacubitril/valsartan significantly reduced heart failure (HF) hospitalization and cardiovascular mortality in a randomized controlled trial. However, little is known about real-world efficacy and safety of sacubitril/valsartan in Chinese patients with HF with reduced ejection fraction (HFrEF). We aimed to evaluate whether sacubitril/valsartan could improve cardiac function in Chinese patients with HFrEF in a tertiary hospital in China.Methods and resultsPatients with HFrEF receiving sacubitril/valsartan in our hospital between January 2018 and January 2020 were recruited in the present study. We retrospectively...
Source: ESC Heart Failure - June 22, 2021 Category: Cardiology Authors: Wenwen Chen, Yanlin Liu, Yuanmin Li, Heqin Dang Tags: Original Research Article Source Type: research

Intra ‐aortic balloon pump on in‐hospital outcomes of cardiogenic shock: findings from a nationwide registry, China
AbstractAimsThe real-world usage of intra-aortic balloon pump (IABP) in various cardiogenic shocks (CS) and the association with outcomes are lacking. We aimed to investigate IABP adoption in CS in a nationwide registry in China.Methods and resultsWe retrospectively retrieved data of 30  106 CS patients (age 67.1 ± 14.6 years, 37.6% female patients) in the Hospital Quality Monitoring System registry from 2013 to 2016. Ischaemic heart disease was the leading cause of CS (73.9%). Hypertension, cardiomyopathy, myocarditis, valvular, and congenital heart disease were seen in 36.0% , 7.5%, 2.6%, 7.3%,...
Source: ESC Heart Failure - June 22, 2021 Category: Cardiology Authors: Songyun Chu, Pengfei Sun, Yan Zhang, Jianping Li, Lin Liu, Ying Shi, Haibo Wang, Hu Chen, Michael Fu, Yong Huo Tags: Original Research Article Source Type: research

Menopausal symptoms and risk of heart failure: a retrospective analysis from Taiwan National Health Insurance Database
ConclusionsMenopausal symptoms were associated with CHD risk but not with risk of HF. Traditional risk factors rather than menopausal symptoms play important roles in the HF risk among middle-aged women. (Source: ESC Heart Failure)
Source: ESC Heart Failure - June 21, 2021 Category: Cardiology Authors: Ching ‐Hui Huang, Chew‐Teng Kor, Ie‐Bin Lian, Chia‐Chu Chang Tags: Original Research Article Source Type: research

Prognostic impact of Clinical Frailty Scale in patients with heart failure with preserved ejection fraction
AbstractAimsFrailty is associated with prognosis of cardiovascular diseases. However, the significance of frailty in patients with heart failure with preserved ejection fraction (HFpEF) remains to be elucidated. The purpose of this study was to examine the prognostic significance of the Clinical Frailty Scale (CFS) in real-world patients with HFpEF using data from a prospective multicentre observational study of patients with HFpEF (PURSUIT-HFpEF study).Method and ResultsWe classified 842 patients with HFpEF enrolled in the PURSUIT-HFpEF study into two groups using CFS. The registry enrolled patients hospitalized with a di...
Source: ESC Heart Failure - June 21, 2021 Category: Cardiology Authors: Akihiro Sunaga, Shungo Hikoso, Takahisa Yamada, Yoshio Yasumura, Masaaki Uematsu, Shunsuke Tamaki, Haruhiko Abe, Yusuke Nakagawa, Yoshiharu Higuchi, Hisakazu Fuji, Toshiaki Mano, Hiroyuki Kurakami, Tomomi Yamada, Tetsuhisa Kitamura, Taiki Sa Tags: Original Research Article Source Type: research

Trajectory of left ventricular geometry and diastolic dysfunction in hereditary transthyretin cardiac amyloidosis
AbstractAmyloid transthyretin (ATTR) depositions cause left ventricular (LV) hypertrophy, diastolic dysfunction, and heart failure. The time course of changes in LV geometry and diastolic dysfunction has not been fully reported in patients with ATTR cardiomyopathy. A 79-year-old woman with previous myocardial infraction presented with shortness of breath on exertion, and progressive bilateral lower extremity weakness and polyneuropathy. She was diagnosed with Val30Met hereditary ATTR cardiomyopathy by cardiac biopsy and genetic testing. During the past 5  year period, significant LV concentric remodelling with small L...
Source: ESC Heart Failure - June 19, 2021 Category: Cardiology Authors: Tatsuya Akatsuka, Naoki Fujimoto, Masaki Ishiyama, Shiro Nakamori, Kyoko Imanaka ‐Yoshida, Kaoru Dohi Tags: Case Report Source Type: research