Testosterone deficiency independently predicts mortality in women with HFrEF: insights from the T.O.S.CA. registry
ConclusionsOne-third of women with HFrEF displays TD that impacts remarkably on their morbidity and mortality. TD is associated with a worse clinical profile including exercise capacity, right ventricular-pulmonary arterial coupling, and renal function. These findings lend support to an accurate profiling of women with HF, a problem often overlooked in clinical trials. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 22, 2022 Category: Cardiology Authors: Alberto M. Marra, Roberta D'Assante, Andrea Salzano, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo, Giuseppe Limongelli, Daniele Masarone, Maria Perticone, Antonio Cimellaro, Pasquale Perrone Filardi, Stefania Paolillo, Paola Gargiulo Tags: Original Article Source Type: research

Risk factors for intracardiac thrombus in peripartum cardiomyopathy: a retrospective study in China
ConclusionsIn our retrospective study, impaired LVEF, elevated haemoglobin levels, and high thrombocyte counts were regarded as independent risk factors for intracardiac thrombus in PPCM. A risk stratification model derived from these risk factors, which was economic and easily applicable in clinical practice, could rapidly and accurately identify PPCM patients with higher-risk of intracardiac thrombus. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 22, 2022 Category: Cardiology Authors: Kang Fu, Hui Zhang, Naiyi Chen, Yue Hu, Jie Xiao, Xinyu Zhang, Zongwei Lin, Huixia Lu, Xiaoping Ji Tags: Original Article Source Type: research

Impact of global warming on weight in patients with heart failure during the 2019 heatwave in France
AbstractHeatwaves affect human health and should be more and more frequent because of global warming and could lead to increase mortality in general population, especially regarding cardiovascular mortality. During the summer 2019, Europe experienced a strong episode of heatwave. Telemonitoring of patients with heart failure (HF) provide an elegant tool to monitor closely the weights, and we assumed to be able to assess our hypothesis through a nationwide telemonitoring system. Here, we hypothesize that (i) there will be a change in patients' weight during the heatwave and (ii) that the telemonitoring would enable us to fo...
Source: ESC Heart Failure - September 22, 2022 Category: Cardiology Authors: Fran çois Roubille, Eric Matzner‐Lober, Sylvain Aguilhon, Max Rene, Laurent Lecourt, Michel Galinier, Jean‐Etienne Ricci, Nicolas Molinari Tags: Short Communication Source Type: research

Contemporary outcome of subsequent pregnancies in patients with previous peripartum cardiomyopathy
ConclusionsOur study indicates a favourable outcome and low likelihood of maternal mortality associated with SSP in women with a history of PPCM and recovered LV systolic function. SSP was associated with a slight reduction in LVEF mostly during the third trimester, which persisted up to 6  months after delivery. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 21, 2022 Category: Cardiology Authors: Sorel Goland, Jacob George, Uri Elkayam, Sara Shimoni, Irena Fugenfirov, Edi Vaisbuch, Michael Arad, Dov Freimark, Michal Simchen, Rafael Kuperstein Tags: Original Article Source Type: research

Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment
We present a case of hereditary transthyretin cardiomyopathy (A97S, an under-represented variant in current clinical studies) who presented with heart failure. Timely diagnosis and intervention with tafamidis demonstrated reversed cardiac remodelling via multiple imaging techniques (echocardiography, cardiac magnetic resonance imaging and technetium-99m pyrophosphate scintigraphy). The echocardiography and cardiac magnetic resonance imaging demonstrated improved global strain. Cardiac magnetic resonance imaging showed decreased extracellular volume. The technetium-99m pyrophosphate scintigraphy demonstrated decreased heart...
Source: ESC Heart Failure - September 21, 2022 Category: Cardiology Authors: Yuan ‐Kun (Aden) Wu, Cheng‐Hsuan Tsai, Mao‐Yuan Su, Chi‐Chao Chao, Mei‐Fang Cheng, Chia‐Tung Shun, Sung‐Tsang Hsieh, Yen‐Hung Lin Tags: Case Report Source Type: research

An echo score raises the suspicion of cardiac amyloidosis in Chinese with heart failure with preserved ejection fraction
ConclusionsThe IWT score by echocardiography was an excellent tool for screening ATTR-CA in HFpEF. In Chinese HFpEF patients associated with a hypertrophic phenotype, the proportion of highly suspected ATTR-CA as detected by IWT score ≥8 was 5.3%, lower than the reported prevalence of ATTR-CA in non-Asian patients with the disease. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 21, 2022 Category: Cardiology Authors: Hong Yang, Rui Li, Fei Ma, Ye Wei, Yujian Liu, Yang Sun, Xingwei He, Hesong Zeng, Jiangtao Yan, Dao Wen Wang, Hong Wang Tags: Original Article Source Type: research

The PARADISE ‐MI trial: a new opportunity to improve the left ventricular remodelling in reperfused STEMI
(Source: ESC Heart Failure)
Source: ESC Heart Failure - September 21, 2022 Category: Cardiology Authors: Alessandro Bellis, Ciro Mauro, Emanuele Barbato, Bruno Trimarco, Carmine Morisco Tags: Editorial Source Type: research

Prevalence and impact of malnutrition on readmission among hospitalized patients with heart failure in China
ConclusionsWe found that the prevalence of malnutrition among hospitalized patients with HF in China is very high and that malnutrition significantly increases the risk of readmission in these patients. CONUT is a validated screening tool for malnutrition and may provide valuable prognostic information. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 20, 2022 Category: Cardiology Authors: Jian Liu, Jing Liu, Jiurui Wang, Zeping Yan, Qian Liang, Xiaoli Wang, Zhiwei Wang, Mengqi Liu, Xiaorong Luan Tags: Original Article Source Type: research

Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure
ConclusionsDespite a higher risk profile among patients with diabetes, sacubitril/valsartan initiation either before or shortly after discharge in hospitalized patients with HFrEF resulted in comparable rates of dose up-titration and tolerability as in those without diabetes. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 20, 2022 Category: Cardiology Authors: Klaus K. Witte, Rolf Wachter, Michele Senni, Jan Belohlavek, Ewa Straburzynska ‐Migaj, Candida Fonseca, Eva Lonn, Adele Noè, Heike Schwende, Dmytro Butylin, YannTong Chiang, Domingo Pascual‐Figal, the TRANSITION investigators Tags: Original Article Source Type: research

Association of congestion with worsening renal function in acute decompensated heart failure according to age
ConclusionsAssociation of residual congestion at discharge with WRF for hospitalized ADHF patients can differ according to age. Our findings showed the importance of WRF and residual congestion at discharge for high-aged ADHF patients and of aggressive diuresis to alleviate congestion for older ADHF patients for better management of such patients in a rapidly ageing society. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 17, 2022 Category: Cardiology Authors: Susumu Odajima, Wataru Fujimoto, Koji Kuroda, Soichiro Yamashita, Junichi Imanishi, Masamichi Iwasaki, Takafumi Todoroki, Masanori Okuda, Takatoshi Hayashi, Akihide Konishi, Masakazu Shinohara, Ryuji Toh, Ken ‐ichi Hirata, Hidekazu Tanaka Tags: Original Article Source Type: research

Sex ‐specific associations of cardiorespiratory fitness and galectin‐3 in the general population
ConclusionsVO2peak was associated with Gal-3 only in men, but VO2peak adjusted for body weight in women and men. Our results suggest that the adverse consequences of low CRF may be mediated by Gal-3. Further research is needed to understand the sex-specific association between CRF and Gal-3 and whether they are clinically relevant. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 17, 2022 Category: Cardiology Authors: Magdalena E. Haid, Stephanie Zylla, Marcello Ricardo Paulista Markus, Nele Friedrich, Ralf Ewert, Sven Gl äser, Stephan B. Felix, Marcus Dörr, Martin Bahls Tags: Original Article Source Type: research

Heart failure during the COVID ‐19 pandemic: clinical, diagnostic, management, and organizational dilemmas
AbstractThe coronavirus 2019 (COVID-19) infection pandemic has affected the care of patients with heart failure (HF). Several consensus documents describe the appropriate diagnostic algorithm and treatment approach for patients with HF and associated COVID-19 infection. However, few questions about the mechanisms by which COVID can exacerbate HF in patients with high-risk (Stage B) or symptomatic HF (Stage C) remain unanswered. Therefore, the type of HF occurring during infection is poorly investigated. The diagnostic differentiation and management should be focused on the identification of the HF phenotype, underlying cau...
Source: ESC Heart Failure - September 16, 2022 Category: Cardiology Authors: Alberto Palazzuoli, Marco Metra, Sean P. Collins, Marianna Adamo, Andrew P. Ambrosy, Laura E. Antohi, Tuvia Ben Gal, Dimitrios Farmakis, Finn Gustafsson, Loreena Hill, Yuri Lopatin, Francesco Tramonte, Alexander Lyon, Josep Masip, Oscar Miro Tags: Review Source Type: research

Incidence and impact of atrial fibrillation in heart failure patients: real ‐world data in a large community
ConclusionsAF is associated with an increment in the risk of episodes of acute heart failure as well as decline of renal function and increment of all-cause mortality. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 16, 2022 Category: Cardiology Authors: Javier Diaz, Fernando Martinez, Jose Miguel Calderon, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Josep Redon, Maria Jose Forner Tags: Original Article Source Type: research

Characteristics and long ‐term survival of patients with left ventricular non‐compaction cardiomyopathy
ConclusionsOur study questions the criteria being used for the diagnosis of LVNC. Further evaluation of CMR variables and association of these findings with demographic variables and survival is mandatory. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 16, 2022 Category: Cardiology Authors: Emre Demir, Selen Bayraktaro ğlu, Akın Çinkooğlu, Aytaç Candemir, Yeşim B. Candemir, Rıza O. Öztürk, Ömer F. Dadaş, Mehmet N. Orman, Mehdi Zoghi, Azem Akıllı, Naim Ceylan, Cemil Gürgün, Sanem Nalbantgil Tags: Original Article Source Type: research

Outcomes with sacubitril/valsartan in outpatients with heart failure and reduced ejection fraction: The ARIADNE registry
ConclusionsThis large HFrEF European registry provides a contemporary outcome profile of outpatients with HFrEF treated with or without sacubitril/valsartan. In a real-world setting, sacubitril/valsartan was associated with an improvement of symptoms in patients with HFrEF compared with the conventional HFrEF treatment. (Source: ESC Heart Failure)
Source: ESC Heart Failure - September 15, 2022 Category: Cardiology Authors: Aldo P. Maggioni, Andrew L. Clark, Vivencio Barrios, Thibaud Damy, Jaroslaw Drozdz, Candida Fonseca, Lars H. Lund, Stefanie Kalus, Philippe C. Ferber, Rizwan I. Hussain, Cornelia Koch, Uwe Zeymer, on behalf of the ARIADNE investigators Tags: Original Article Source Type: research