Recurrent autoimmune myocarditis in a young woman during the coronavirus disease 2019 pandemic
We report a unique case of a young woman with recurrent immune ‐mediated (virus‐negative) lymphocytic fulminant myocarditis during the coronavirus disease 2019 pandemic. At the first endomyocardial biopsy (EMB)‐proven episode, she had concomitant pneumonia, and a temporary biventricular assist device implant was followed by complete and long‐lasting car diac recovery. Five years later, she was re‐admitted for relapsing cardiogenic shock with a recent history of pneumonia. She was treated with extracorporeal life support with apical venting for left ventricular unloading, and full recovery was achieved. Despite ne...
Source: ESC Heart Failure - November 22, 2020 Category: Cardiology Authors: Raphael Caraffa, Renzo Marcolongo, Tomaso Bottio, Stefania Riza, Olimpia Bifulco, Lorenzo Bagozzi, Augusto D'Onofrio, Alida L.P. Caforio, Vjola Jorgji, Cristina Basso, Gino Gerosa Tags: Case Report Source Type: research

Epidemiology of acutely decompensated systolic heart failure over the 2003 –2013 decade in Douala General Hospital, Cameroon
This study explores the epidemiology and prognostic factors of ADHF in Cameroonian patients.Methods and resultsThis was a retrospective study conducted between January 2003 and December 2013 from the medical files of patients followed at the intensive care and cardiovascular units of Douala General Hospital in Cameroon. Clinical, electrocardiographic, echocardiographic, and biological data were collected from 142 patients (58.5% men; mean age 58  ± 14 years) hospitalized for ADHF with reduced ejection fraction (HFrEF), whose left ventricular ejection fraction was70  mg/L (84.9%,n = 121)...
Source: ESC Heart Failure - November 22, 2020 Category: Cardiology Authors: Daniel Lemogoum, F élicité Kamdem, Hamadou Ba, William Ngatchou, Guillaume Hye Ndindjock, Anasthase Dzudie, Yves Monkam, Sidick Mouliom, Michel P. Hermans, Elysée Claude Bika Lele, Philippe Borne Tags: Original Research Article Source Type: research

Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence
AbstractTwo highly prevalent and growing global diseases impacted by skeletal muscle atrophy are chronic heart failure (HF) and type 2 diabetes mellitus (DM). The presence of either condition increases the likelihood of developing the other, with recent studies revealing a large and relatively poorly characterized clinical population of patients with coexistent HF and DM (HFDM). HFDM results in worse symptoms and poorer clinical outcomes compared with DM or HF alone, and cardiovascular ‐focused disease‐modifying agents have proven less effective in HFDM indicating a key role of the periphery. This review combines curre...
Source: ESC Heart Failure - November 22, 2020 Category: Cardiology Authors: Nathanael Wood, Sam Straw, Mattia Scalabrin, Lee D. Roberts, Klaus K. Witte, Thomas Scott Bowen Tags: Review Source Type: research

Potts anastomosis in children with severe pulmonary arterial hypertension and atrial septal defect
ConclusionsShunt physiology is only partially predictable after the Potts shunt in children with PAH and atrial septal defect. Abrupt drop in left ventricle preload while the right ventricle is decompressed can potentially be prevented by atrial septal defect closure prior to the Potts shunt. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Alice Capel, Marilyne L évy, Isabelle Szezepanski, Sophie Malekzadeh‐Milani, Pascal Vouhé, Damien Bonnet Tags: Original Research Article Source Type: research

Clinical characteristics and outcomes of black African heart failure patients with preserved, mid ‐range, and reduced ejection fraction: a post hoc analysis of the THESUS‐HF registry
ConclusionsClassification by LVEF according to European Society of Cardiology guidelines revealed some differences in clinical presentation but similar mortality and rehospitalization rates across all EF groups in Africans admitted for HF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Anastase Dzudie, Martin Hongieh Abanda, Clovis Nkoke, Blaise Barche, Albertino Damasceno, Christopher Edwards, Beth Davison, Gad Cotter, Karen Sliwa, On behalf of THEUS ‐HF investigators, Albertino Damasceno, Mahmoud Sani, Dike Ojji, Ahmed Tags: Original Research Article Source Type: research

Renin profiling predicts neurohormonal response to sacubitril/valsartan
AbstractAimsClinical trials and observational cohorts show that beneficial effects of sacubitril/valsartan are less strong in an appreciable proportion of patients with heart failure with reduced ejection fraction (HFrEF). Lower blood pressure and impaired renal function predict suboptimal sacubitril/valsartan titration and a less favourable response. Circulating renin encompasses neurohormonal activation, intravascular volume, and renal function. We hypothesized that renin may predict response to sacubitril/valsartan, assessed by changes in N ‐terminal fraction of pro‐brain natriuretic peptide (NT‐proBNP).Methods an...
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Giuseppe Vergaro, Paolo Sciarrone, Concetta Prontera, Silvia Masotti, Veronica Musetti, Alessandro Valleggi, Alberto Giannoni, Michele Senni, Michele Emdin, Claudio Passino Tags: Short Communication Source Type: research

Ventricular assist device for a coronavirus disease 2019 ‐affected heart
AbstractCoronavirus disease 2019 (COVID ‐19) is challenging the care for cardiovascular patients, resulting in serious consequences with increasing mortality in pre‐diseased heart failure patients. In the current state of the pandemic, the physiopathology of COVID‐19 affecting pre‐diseased hearts and the management of terminal hea rt failure in COVID‐19 patients remain unclear. We outline the findings of a young COVID‐19 patient suffering from idiopathic cardiomyopathy who was treated for acute multi‐organ failure and required cardiac surgery with implantation of a temporary right ventricular and durable left...
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Tienush Rassaf, Matthias Totzeck, Amir A. Mahabadi, Ulrike Hendgen ‐Cotta, Sebastian Korste, Stephan Settelmeier, Peter Luedike, Ulf Dittmer, Frank Herbstreit, Thorsten Brenner, Karin Klingel, Mike Hasenberg, Bernd Walkenfort, Matthias Gunz Tags: Case Report Source Type: research

Prognostic value of the H2FPEF score in patients undergoing transcatheter aortic valve implantation
AbstractAimsThe aim of this study was to assess the prognostic value of the H2FPEF score in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and preserved left ventricular ejection fraction (EF).Methods and resultsIn this multicentre study, a total of 832 patients from two German high ‐volume centres, who received TAVI for severe AS and preserved EF (≥50%), were identified for calculation of the H2FPEF score. Patients were dichotomized according to low (0 –5 points;n = 570) and high (6–9 points;n = 262) H2FPEF scores. Kaplan –Meier...
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Sebastian Ludwig, Costanza Pellegrini, Alina Gossling, Tobias Rheude, Lisa Voigtl änder, Oliver D. Bhadra, Matthias Linder, Daniel Kalbacher, Benedikt Koell, Lara Waldschmidt, Johannes Schirmer, Moritz Seiffert, Hermann Reichenspurner, Stefa Tags: Original Research Article Source Type: research

MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and/or virally induced cardiomyopathies
AbstractAimsMicroRNAs (miRNAs) might be used as prospective biomarkers for the identification of unexplained heart failure caused by a viral and/or inflammatory process. The aim of this study was to identify and to evaluate prognostic miRNAs in serum of patients with inflammatory heart diseases diagnosed by endomyocardial biopsies.Methods and resultsAfter TaqMan ® OpenArray® screening of 754 unique circulating miRNAs in serum of biopsy‐proven patients [184 patients with inflammatory and/or virally induced myocardial diseases (DCMi), 25 patients with dilated cardiomyopathy (DCM), and 25 healthy donors], we identif...
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Ganna Aleshcheva, Heiko Pietsch, Felicitas Escher, Heinz ‐Peter Schultheiss Tags: Original Research Article Source Type: research

Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID ‐19
ConclusionsNHE1 and GLUT1 may be critically involved in the disease progression of SARS ‐CoV‐2 infection. We show here that SARS‐CoV‐2 infection critically disturbs ion channel expression in the heart. A decreased ratio of GLUT1/NHE1 could potentially serve as a biomarker for disease severity in patients with COVID‐19. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 20, 2020 Category: Cardiology Authors: Julian Mustroph, Julian Hupf, Frank Hanses, Katja Evert, Maria J. Baier, Matthias Evert, Christine Meindl, Stefan Wagner, Ute Hubauer, Gabriela Pietrzyk, Simon Leininger, Stephan Staudner, Manuel Vogel, Stefan Wallner, Markus Zimmermann, Sa Tags: Original Research Article Source Type: research

Evidence of evolution towards left midventricular obstruction in severe Anderson –Fabry cardiomyopathy
ConclusionsFabry cardiomyopathy can evolve over time towards a midventricular obstructive form due to massive LVH in classically affected men with significant diagnostic delay and severe LVH before enzyme replacement therapy initiation. This newly described cardiac phenotype could represent an adverse outcome of the disease. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 19, 2020 Category: Cardiology Authors: Francesca Graziani, Rosa Lillo, Elena Panaioli, Gionata Spagnoletti, Maurizio Pieroni, Paolo Ferrazzi, Antonia Camporeale, Elena Verrecchia, Ludovico Luca Sicignano, Raffaele Manna, Filippo Crea Tags: Short Communication Source Type: research

Comprehensive plasma metabolites profiling reveals phosphatidylcholine species as potential predictors for cardiac resynchronization therapy response
ConclusionsPatients with HF held significantly altered plasma metabolomics profile compared with the healthy individuals. Within the HF group, the non ‐responders had a distinct plasma metabolomics profile in contrast to the responders to CRT, which was characterized by increased PCs species. A novel predictive model incorporating four PCs metabolites performed well in identifying CRT non‐responders. These four PCs might severe as potential bi omarkers for predicting CRT response. Further validations are needed in multi‐centre studies with larger external cohorts. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 19, 2020 Category: Cardiology Authors: Shengwen Yang, Yiran Hu, Junhan Zhao, Ran Jing, Jing Wang, Min Gu, Hongxia Niu, Liang Chen, Wei Hua Tags: Original Research Article Source Type: research

Increased susceptibility to SARS ‐CoV‐2 infection in patients with reduced left ventricular ejection fraction
ConclusionsIn a large cohort of patients with previous ACS, reduced LVEF was associated with increased susceptibility to COVID ‐19. Aggressive COVID‐19 testing and therapeutic strategies may be considered for patient with impaired heart function. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 18, 2020 Category: Cardiology Authors: Kensuke Matsushita, Benjamin Marchandot, Adrien Carmona, Anais Curtiaud, Anis El Idrissi, Antonin Trimaille, Marion Kibler, Thomas Cardi, Joe Heger, Sebastien Hess, Antje Reydel, Laurence Jesel, Patrick Ohlmann, Olivier Morel Tags: Original Research Article Source Type: research

Impact of residual inflammation on myocardial recovery and cardiovascular outcome in Takotsubo patients
ConclusionsResidual high inflammatory response was associated with impaired LVEF at follow up and was evidenced as an independent factor of cardiovascular events. All together, these findings underline RHIR patients as a high ‐risk subgroup, to target in future clinical trials with specific therapies to attenuate RHIR. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 18, 2020 Category: Cardiology Authors: Lucie Lachmet ‐Thebaud, Benjamin Marchandot, Kensuke Matsushita, Chisato Sato, Charlotte Dagrenat, Stephane Greciano, Fabien De Poli, Pierre Leddet, Marilou Peillex, Sébastien Hess, Adrien Carmona, Charline Jimenez, Joe Heger, Antje Reydel Tags: Original Research Article Source Type: research

Aortic valve replacement: validation of the Toronto Aortic Stenosis Quality of Life Questionnaire
AbstractAimsThere is no quality of life tool specifically developed for patients with severe aortic stenosis (AS) to assess how this chronic condition and its treatment affect patients. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) has been developed to overcome this gap. The results of the validation of the TASQ in patients undergoing treatment for severe AS are presented.Methods and resultsProspective study at 10 centres in Europe and Canada, which enrolled 274 patients with severe symptomatic AS undergoing surgical or transcatheter aortic valve replacement. Mean TASQ score at baseline was 71.2 points ...
Source: ESC Heart Failure - November 18, 2020 Category: Cardiology Authors: Derk Frank, Simon Kennon, Nikolaos Bonaros, Lukas Stastny, Mauro Romano, Thierry Lef èvre, Carlo Di Mario, Pierluigi Stefàno, Flavio Ribichini, Dominique Himbert, Marina Urena‐Alcazar, Jorge Salgado‐Fernandez, Jose Joaquin Cuenca Castill Tags: Original Research Article Source Type: research

Cardiac output changes during exercise in heart failure patients: focus on mid ‐exercise
AbstractAimsPeak exercise oxygen uptake (VO2) and cardiac output (CO) are strong prognostic indexes in heart failure (HF) but unrelated to real ‐life physical activity, which is associated to submaximal effort.Methods and resultsWe analysed maximal cardiopulmonary exercise test with rest, mid ‐exercise, and peak exercise non‐invasive CO measurements (inert gas rebreathing) of 231 HF patients and 265 healthy volunteers. HF patients were grouped according to exercise capacity (peak VO2 
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Nicoletta Corrieri, Alberico Del Torto, Carlo Vignati, Riccardo Maragna, Fabiana De Martino, Martina Cellamare, Stefania Farina, Elisabetta Salvioni, Alice Bonomi, Piergiuseppe Agostoni Tags: Original Research Article Source Type: research

Appropriateness rating for the application of optimal medical therapy and multidisciplinary care among heart failure patients
AbstractAimsClinical guidelines for improving the patients' quality of care vary in clinical practice, particularly in super ‐aging societies, like in Japan. We aimed to develop a set of appropriate‐use criteria (AUC) for contemporary heart failure (HF) management to assist physicians in decision making.Methods and resultsWith the use of the RAND methodology, a multidisciplinary writing group developed patient ‐based clinical scenarios in 10 selected key topics, stratified mainly by HF stage, age, and renal function. Nine nationally recognized expert panellists independently rated the clinical scenario appropriatenes...
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Satoshi Shoji, Shun Kohsaka, Yasuyuki Shiraishi, Shogo Oishi, Mahoto Kato, Shigehito Shiota, Yasuko Takada, Atsushi Mizuno, Dai Yumino, Hiroyuki Yokoyama, Noboru Watanabe, Mitsuaki Isobe Tags: Original Research Article Source Type: research

Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: G ábor Tamás Szabó, Attila Kiss, Zoltán Csanádi, Dániel Czuriga Tags: Editorial Source Type: research

Feasibility of high ‐intensity interval training in patients with left ventricular assist devices: a pilot study
ConclusionsCardiopulmonary exercise test ‐guided HIIT is feasible and can improve submaximal aerobic capacity in stable patients with chronic LVAD support. Further studies are needed on its effects on the myocardium and its potential role in cardiac rehabilitation programmes. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Miguel Alvarez Villela, Thiru Chinnadurai, Kalil Salkey, Andrea Furlani, Mounica Yanamandala, Sasha Vukelic, Daniel B. Sims, Jooyoung J. Shin, Omar Saeed, Ulrich P. Jorde, Snehal R. Patel Tags: Original Research Article Source Type: research

Machine learning vs. conventional statistical models for predicting heart failure readmission and mortality
ConclusionsML algorithms had better discrimination than CSMs in most studies aiming to predict risk of readmission and mortality in HF patients. Based on our review, there is a need for external validation of ML ‐based studies of prediction modelling. We suggest that ML‐based studies should also be evaluated using clinical quality standards for prognosis research. Registration: PROSPERO CRD42020134867 (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Sheojung Shin, Peter C. Austin, Heather J. Ross, Husam Abdel ‐Qadir, Cassandra Freitas, George Tomlinson, Davide Chicco, Meera Mahendiran, Patrick R. Lawler, Filio Billia, Anthony Gramolini, Slava Epelman, Bo Wang, Douglas S. Lee Tags: Original Research Article Source Type: research

Implication of inhaled nitric oxide for the treatment of critically ill COVID ‐19 patients with pulmonary hypertension
ConclusionsInhaled nitric oxide treatment was beneficial in reducing and stabilizing the PASP and might also reduce the risk of right heart failure in COVID ‐19 with pulmonary hypertension. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Wen ‐Xia Feng, Yang Yang, Junmin Wen, Ying‐Xia Liu, Lei Liu, Cheng Feng Tags: Short Communication Source Type: research

Prevalence of wild type transtyrethin cardiac amyloidosis in a heart failure clinic
ConclusionsApproximately 20% of investigated patients in a cohort with heart failure and increased myocardial wall thickness has ATTRwt. Calculated for the whole population of heart failure patients, the prevalence is just over 1.1%. Comparing this number to the total population would give an estimated prevalence of 1:6000. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 17, 2020 Category: Cardiology Authors: Krister Lindmark, Bj örn Pilebro, Torbjörn Sundström, Per Lindqvist Tags: Short Communication Source Type: research

Sudden cardiogenic shock mimicking fulminant myocarditis in a surviving teenager affected by severe acute respiratory syndrome coronavirus 2 infection
AbstractIn the context of the coronavirus disease 2019 pandemic, myocardial injury is a relatively frequent finding. Progression to cardiogenic shock has been rarely described, especially in healthy young patients. The underlying mechanisms are to date controversial. A previously healthy 18 ‐year‐old female teenager affected by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) developed fulminant cardiogenic shock requiring a prompt extracorporeal membrane oxygenation support. Cardiac involvement was predominant compared with the pulmonary one. Myocardial biopsies we re performed; and in order to clarify...
Source: ESC Heart Failure - November 15, 2020 Category: Cardiology Authors: Giovanni Garau, Sabrina Joachim, Guy ‐Loup Duliere, Maria Melissopoulou, Sandrine Boccar, Vincent Fraipont, Christophe Dugauquier, Pierre Troisfontaines, Olivier Hougrand, Philippe Delvenne, Etienne Hoffer Tags: Case Report Source Type: research

Discontinuation and non ‐publication of heart failure randomized controlled trials: a call to publish all trial results
ConclusionsDiscontinuation and non ‐publication of HF trials is common. This raises ethical concerns towards participants who volunteer for research and are exposed to potential risks, inconvenience, and discomfort without furthering scientific progress. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 15, 2020 Category: Cardiology Authors: Muhammad Shahzeb Khan, Izza Shahid, Nava Asad, Stephen J. Greene, Safi U. Khan, Rami Doukky, Marco Metra, Stefan D. Anker, Gerasimos S. Filippatos, Gregg C. Fonarow, Javed Butler Tags: Original Research Article Source Type: research

Cardiac adaptations to 60 day head ‐down‐tilt bed rest deconditioning. Findings from the AGBRESA study
AbstractAimsReduced physical activity increases the risk of heart failure; however, non ‐invasive methodologies detecting subclinical changes in myocardial function are not available. We hypothesized that myocardial, left ventricular, systolic strain measurements could capture subtle abnormalities in myocardial function secondary to physical inactivity.Methods and resultsIn the AGBRESA study, which assessed artificial gravity through centrifugation as potential countermeasure for space travel, 24 healthy persons (eight women) were submitted to 60  day strict −6° head‐down‐tilt bed rest. Participants we...
Source: ESC Heart Failure - November 15, 2020 Category: Cardiology Authors: Fabian Hoffmann, J érémy Rabineau, Dennis Mehrkens, Darius A. Gerlach, Stefan Moestl, Bernd W. Johannes, Enrico G. Caiani, Pierre Francois Migeotte, Jens Jordan, Jens Tank Tags: Short Communication Source Type: research

Impact of a volume challenge on haemodynamics and prognosis in patients with severe aortic stenosis
ConclusionsIn severe AS, a contrast challenge leads to post ‐contrast PH in ~40% of patients without pre‐contrast PH. However, post‐contrast haemodynamic changes do not adversely affect outcomes in patients undergoing AVR. Post‐contrast PH represents an intermediate stage of ‘cardiac damage’, which may be attenuated or reversible after AVR. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 12, 2020 Category: Cardiology Authors: Micha T. Maeder, Lukas Weber, Daniel Weilenmann, Philipp K. Haager, Lucas Joerg, Franziska Rohner, Peter Ammann, Joannis Chronis, Johannes Rigger, Hans Rickli Tags: Original Research Article Source Type: research

Temporal trends of a vasopressin V2 receptor antagonist in heart failure using a nationwide database in Japan
ConclusionsThis large ‐scale survey indicated an increased rate of tolvaptan prescription and an early shift to tolvaptan treatment in patients with HF in Japan. The prognostic effects of this change in HF treatment remain unclear. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 12, 2020 Category: Cardiology Authors: Takashi Kuragaichi, Yukihito Sato Tags: Original Research Article Source Type: research

Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry
This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non ‐familial (sporadic) DCM (SDCM) across Europe.Methods and resultsPatients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy& Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P 
Source: ESC Heart Failure - November 11, 2020 Category: Cardiology Authors: Folkert W. Asselbergs, Arjan Sammani, Perry Elliott, Juan R. Gimeno, Luigi Tavazzi, Michael Tendera, Juan Pablo Kaski, Aldo P. Maggioni, Pawel P. Rubis, Ruxandra Jurcut, Tiina Heli ö, Leonardo Calò, Gianfranco Sinagra, Marija Zdravkovic, I Tags: Original Research Article Source Type: research

Clinical phenotypes, aetiologies, management, and mortality in acute heart failure: a single ‐institution study in Latin‐America
This study sought to assess the prevalence of, and identify differences among, in ‐hospital outcomes in patients hospitalized for AHF who were stratified by clinical phenotype at a hospital in Latin America.Methods and resultsThis is a retrospective cohort study of patients with AHF who were hospitalized in the coronary care unit of a Latin American teaching hospital from January 2006 to December 2018. Cox regression analysis was used to identify predictors of mortality. Of 21  042 patients admitted, 7759 (36.6%) had AHF. Their median age was 62 years, and 35% were women.De novo heart failure was seen in 39.4% ...
Source: ESC Heart Failure - November 11, 2020 Category: Cardiology Authors: H éctor González‐Pacheco, Amada Álvarez‐Sangabriel, Carlos Martínez‐Sánchez, José L. Briseño‐Cruz, Alfredo Altamirano‐Castillo, Salvador Mendoza‐García, Daniel Manzur‐Sandoval, Luis M. Amezcua‐Guerra, Julio Sandoval, Rafae Tags: Original Research Article Source Type: research

An increase in acute heart failure offsets the reduction in acute coronary syndrome during coronavirus disease 2019 (COVID ‐19) outbreak
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 11, 2020 Category: Cardiology Authors: Patrick Sulzgruber, Mario Krammel, Patrick Aigner, Georg Pfenneberger, Albert Espino, Johannes Stommel, Klaus Herbich, Felix Hofer, Niema Kazem, Lorenz Koller, Christian Hengstenberg, Alexander Niessner Tags: Letter to the Editor Source Type: research

Comparable outcomes between genders in patients undergoing surgical ventricular reconstruction for ischaemic heart failure
AbstractAimsFemale sex and heart failure (HF) are considered poor prognostic factors for surgery. We aimed to investigate the association between sex and surgical outcomes in patients with ischaemic HF undergoing surgical ventricular reconstruction and coronary artery bypass grafting.Methods and resultsFrom July 2001 to June 2017, 648 patients [111 women (17%) and 537 men (83%)] were referred to our centre. Follow ‐up continued through June 2018. All patients underwent surgical ventricular reconstruction; coronary artery bypass grafting was performed in 582 patients (90%). Primary outcome was defined as all‐cause morta...
Source: ESC Heart Failure - November 10, 2020 Category: Cardiology Authors: Serenella Castelvecchio, Valentina Milani, Marianna Volpe, Michele Citarella, Federico Ambrogi, Sara Boveri, Guglielmo Saitto, Andrea Garatti, Lorenzo Menicanti Tags: Original Research Article Source Type: research

Heterogeneity of health status treatment response with sacubitril/valsartan: insights from the CHAMP ‐HF registry
ConclusionsWe found that, after initiation of sacubitril/valsartan, only worse baseline health status was associated with very large health status improvement. Accordingly, a trial of therapy —particularly in those with worse symptoms, function, and quality of life—and assessing treatment response are likely to be the best prospective strategy. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 10, 2020 Category: Cardiology Authors: Yevgeniy Khariton, Gregg C. Fonarow, Ann Hellkamp, Laine Thomas, Michael E. Nassif, Javed Butler, Carol I. Duffy, Nancy M. Albert, John A. Spertus Tags: Short Communication Source Type: research

Biventricular pacemaker and defibrillator implantation in patients with chronic heart failure in China
ConclusionsIn China, among CHF patients with indications for primary prevention of SCD who received device implantation, non ‐ischaemic CHF was the main aetiology, and the most important cause of death was heart failure. No differences in all‐cause death were observed between the CRT‐D and CRT‐P groups, but the CRT‐D group had a lower SCD rate than the CRT‐P group. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 9, 2020 Category: Cardiology Authors: Dejia Huang, Wei Hua, Quan Fang, Ji Yan, Yangang Su, Bing Liu, Yuanning Xu, Yong Peng, POSCD ‐China Investigators Tags: Original Research Article Source Type: research

Risk of stroke in patients with heart failure and sinus rhythm: data from the Swedish Heart Failure Registry
ConclusionsIn terms of absolute risk, only 27.6% of patients had an annual IS incidence of ≤1%. To which extent this would be amenable to anticoagulant treatment remains conjectural. A score compiling age and specific co‐morbidities identified HF‐SR patients with increased risk of IS with modest discriminative ability. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 9, 2020 Category: Cardiology Authors: Clara Hjalmarsson, Michael Fu, Tatiana Zverkova Sandstr öm, Maria Schaufelberger, Charlotta Ljungman, Björn Andersson, Entela Bollano, Ulf Dahlström, Annika Rosengren Tags: Original Research Article Source Type: research

Heart failure epidemiology and treatment in primary care: a retrospective cross ‐sectional study
ConclusionsPrevalence of heart failure among patients treated by general practitioners was low. Considering the disease burden and association with multimorbidity, awareness of heart failure in primary care should be increased, with the aim to optimize heart failure therapy. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 7, 2020 Category: Cardiology Authors: Yael Rachamin, Rahel Meier, Thomas Rosemann, Andreas J. Flammer, Corinne Chmiel Tags: Original Research Article Source Type: research

Impella 5.0 supported oncological surgery as bridge to LVAD
We describe the case of a 58 ‐year‐old man presenting with myocardial infarction complicated by cardiogenic shock, treated with Impella CP which was escalated to an axillary 5.0 due to lack of cardiac recovery. Weaning from Impella 5.0 failed, and the patient was evaluated for heart transplantation (HTx) or left ventricular assist device (LVAD). HTx was excluded because of a rectal adenocarcinoma. The patient underwent colorectal surgery while on Impella. Perioperative course was uneventful. After 61 days of Impella, when the LVAD implantation was scheduled, the patient died due toK.  pneumoniae infection. (S...
Source: ESC Heart Failure - November 7, 2020 Category: Cardiology Authors: Andrea Montisci, Giancarlo Micheletto, Serena Sibilio, Francesco Donatelli, Maurizio Tespili, Carlo Banfi, Francesco Casilli, Daniele Cosseta, Antonio Miceli, Silvia Cirri, Federico Pappalardo Tags: Case Report Source Type: research

Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof ‐of‐concept study
AbstractAimsCardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine –isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof‐of‐concept study aimed to evaluate early evidence of efficacy, safety, and feasibility of H‐ISDN compared with standard of care in CRS.Methods and resultsThis multi ‐centre, single‐blind, randomized trial in Singapore enrolled CRS patients, defined as chronic HF with concomitant renal failure [estimated glomerular filtration rate (eGFR) 
Source: ESC Heart Failure - November 4, 2020 Category: Cardiology Authors: Shir Lynn Lim, Mihir Gandhi, Kai Lee Woo, Horng Ruey Chua, Yoke Ching Lim, David K.L. Sim, Sheldon S.G. Lee, Yee Leong Teoh, Arthur Mark Richards, Carolyn S.P. Lam Tags: Original Research Article Source Type: research

Pathophysiological role of fatty acid ‐binding protein 4 in Asian patients with heart failure and preserved ejection fraction
AbstractAimsSystemic metabolic impairment is the key pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). Fatty acid ‐binding protein 4 (FABP4) is highly expressed in adipocytes and secreted in response to lipolytic signals. We hypothesized that circulating FABP4 levels would be elevated in patients with HFpEF, would correlate with cardiac structural and functional abnormalities, and could predict clinical outco mes.Methods and resultsSerum FABP4 measurements and echocardiography were performed in patients with HFpEF (n = 92) and those with coronary artery disease free of HF (n =...
Source: ESC Heart Failure - November 2, 2020 Category: Cardiology Authors: Tomonari Harada, Hiroaki Sunaga, Hidemi Sorimachi, Kuniko Yoshida, Toshimitsu Kato, Koji Kurosawa, Takashi Nagasaka, Norimichi Koitabashi, Tatsuya Iso, Masahiko Kurabayashi, Masaru Obokata Tags: Original Research Article Source Type: research

Associations of region ‐specific visceral adiposity with subclinical atrial dysfunction and outcomes of heart failure
AbstractAimsExcessive visceral adiposity (VAT) plays an essential role in metabolic derangements with those close to heart further mediates myocardial homeostasis. The disparate biological links between region ‐specific VAT and cardiometabolic profiles as mediators influencing atrial kinetics remain unexplored.Methods and resultsAmong 1326 asymptomatic individuals, region ‐specific VAT including peri‐aortic root fat (PARF) and total pericardial fat (PCF) of cardiac region, together with thoracic peri‐aortic adipose tissue (TAT), was assessed using multiple‐detector computed tomography. VAT measures were related t...
Source: ESC Heart Failure - October 28, 2020 Category: Cardiology Authors: Bo ‐Han Huang, Shun‐Chuan Chang, Chun‐Ho Yun, Kuo‐Tzu Sung, Yau‐Huei Lai, Chi‐In Lo, Wen‐Hung Huang, Shih‐Chieh Chien, Lawrence Yu‐Min Liu, Ta‐Chuan Hung, Jen‐Yuan Kuo, Jiun‐Lu Lin, Bernard Bulwer, Charles Jia‐Yin Ho Tags: Original Research Article Source Type: research

ESC Heart Failure increases its impact factor
ESC Heart Failure, EarlyView. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 28, 2020 Category: Cardiology Authors: Markus S. Anker, Zolt án Papp, Gábor Földes, Stephan Haehling Tags: Editorial Source Type: research

Prediction of worsening heart failure events and all ‐cause mortality using an individualized risk stratification strategy
This study aimed to examine the clinical utility of a multisensor, remote, ambulatory diagnostic risk score, TriageHF ™, in a real‐world, unselected, large patient sample to predict heart failure events (HFEs) and all‐cause mortality.Methods and resultsTriageHF risk score was calculated in patients in the Optum® database who had Medtronic implantable cardiac defibrillator device from 2007 to 2016. Patients were categorized into three risk groups based on probability for having an HFE within 6  months (low risk
Source: ESC Heart Failure - October 28, 2020 Category: Cardiology Authors: Michael R. Zile, Jodi Koehler, Shantanu Sarkar, Javed Butler Tags: Original Research Article Source Type: research

Cost ‐effectiveness of adding dapagliflozin to standard treatment for heart failure with reduced ejection fraction patients in China
ConclusionsDapagliflozin was a very cost ‐effective treatment option for HFrEF patients in China according to the result of our model. Our findings will help doctors and health care payers to make decisions in clinical practice. Future real‐world studies of cost‐effectiveness of dapagliflozin based on Chinese population were also nee ded. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 27, 2020 Category: Cardiology Authors: Younan Yao, Rongcheng Zhang, Tao An, Xinke Zhao, Jian Zhang Tags: Original Research Article Source Type: research

Regional protein expression changes within the left ventricle in a mouse model of dyssynchronous and resynchronized heart failure
AbstractAimsThe biological mechanisms conveying the salutary effects of cardiac resynchronization therapy in heart failure remain elusive. We have recently developed a mouse model of heart failure with dyssynchrony/resynchronization. The aim of this study was to characterize regional left ventricular heterogeneity in protein expression comparing early (septum) and late (lateral) activated left ventricular wall segments in synchronous (SHF), dyssynchronous (DHF), and resynchronized heart failure (RHF).Methods and resultsMice subjected to ischaemia/reperfusion were divided into three groups: sinus rhythm for 4  weeks (S...
Source: ESC Heart Failure - October 27, 2020 Category: Cardiology Authors: Hugo Nordin, Ryo Nakagawa, Marita Wallin, John Pernow, David A. Kass, Marcus St åhlberg Tags: Short Communication Source Type: research

Prognostic value of D ‐dimer in acute myocardial infarction complicated by heart failure with preserved ejection fraction
ConclusionsHigh D ‐dimer levels on admission were found to be strongly associated with the subsequent cumulative incidence of all‐cause mortality in patients with AMI complicated by HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 26, 2020 Category: Cardiology Authors: Xiaoyuan Zhang, Shanjie Wang, Liping Sun, Shaohong Fang, Bo Yu Tags: Original Research Article Source Type: research

MitraClip implantation followed by insertion of a left ventricular assist device in patients with advanced heart failure
ConclusionsLVAD implantation after MC is feasible and safe. However, in patients with advanced HF and severe MR, PMVR may only delay a needed LVAD implantation and thereby lead to poorer peri ‐operative RV function and impaired outcome. Arguably, these patients might benefit from the timely management of advanced HF by the means of early LVAD implantation or heart transplantation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 26, 2020 Category: Cardiology Authors: Michael M. Kreusser, Sonja Hamed, Andreas Weber, Bastian Schmack, Martin J. Volz, Nicolas A. Geis, Leonie Grossekettler, Sven T. Pleger, Arjang Ruhparwar, Hugo A. Katus, Philip W. Raake Tags: Original Research Article Source Type: research

Delayed acute myocarditis and COVID ‐19‐related multisystem inflammatory syndrome
We describe clinical presentation and diagnostic workup of acute myocarditis in a patient who had developed COVID‐19 syndrome 1 month earlier. A healthy 40‐year‐old man suffered from typical COVID‐19 symptoms. Four weeks later, he was admitted because of fever and tonsillitis. Blood tests showed major inflammation. Thoracic computed tomography was normal, and RT–PCR for SARS‐CoV‐2 on nasopharyngeal swab was negative. Because of haemodynamic worsening with both an increase in cardiac troponin and B‐typ e natriuretic peptide levels and normal electrocardiogram, acute myocarditis was suspected. Cardia...
Source: ESC Heart Failure - October 26, 2020 Category: Cardiology Authors: Martin Nicol, Lea Cacoub, Mathilde Baudet, Yoram Nahmani, Patrice Cacoub, Alain Cohen ‐Solal, Patrick Henry, Homa Adle‐Biassette, Damien Logeart Tags: Case Report Source Type: research

Myocarditis and intramural coronary vasculitis in polyarteritis nodosa: an unusual treatable form of heart failure
We describe an uncommon cardiac presentation of polyarteritis nodosa. A 68 ‐year‐old woman, with a history of fatigue, weight loss, and myalgia of the lower extremities, was admitted for congestive heart failure. Coronary arteries were normal. Endomyocardial biopsy showed active lymphocytic myocarditis with associated intramural small vessels necrotizing vasculitis. Th e overexpression of TLR‐4 and the negativity for myocardial viruses suggested an immune mediated mechanism of cardiac damage. These histologic findings associated to weight loss>4  kg not due to dieting or other factors, myalgias, and polyneuro...
Source: ESC Heart Failure - October 23, 2020 Category: Cardiology Authors: Cristina Chimenti, Maria Alfarano, Federica Toto, Francesca Fanisio, Romina Verardo, Nicola Galea, Luciano Agati, Andrea Frustaci Tags: Case Report Source Type: research

Reduction in heart failure hospitalization rate during coronavirus disease 19 pandemic outbreak
AbstractAimsThe recent coronavirus disease 19 (COVID ‐19) pandemic outbreak forced the adoption of restraint measures, which modified the hospital admission patterns for several diseases. The aim of the study is to investigate the rate of hospital admissions for heart failure (HF) during the early days of the COVID‐19 outbreak in Italy, compared w ith a corresponding period during the previous year and an earlier period during the same year.Methods and resultsWe performed a retrospective analysis on HF admissions number at eight hospitals in Italy throughout the study period (21 February to 31 March 2020), compared wit...
Source: ESC Heart Failure - October 23, 2020 Category: Cardiology Authors: Paolo Severino, Andrea D'Amato, Andrea Saglietto, Fabrizio D'Ascenzo, Claudia Marini, Marco Schiavone, Nicol ò Ghionzoli, Filippo Pirrotta, Francesca Troiano, Margherita Cannillo, Marco Mennuni, Andrea Rognoni, Francesco Rametta, Alessandro Tags: Original Research Article Source Type: research

Cardiopoietic stem cell therapy in ischaemic heart failure: long ‐term clinical outcomes
ConclusionsLongitudinal follow ‐up documents that cardiopoietic stem cell therapy is overall safe, and post hoc analyses suggest benefit in an ischaemic heart failure subpopulation defined by advanced left ventricular enlargement on tolerable stem cell dosing. The long‐term clinical follow‐up thus offers guidance for future targeted trials. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 23, 2020 Category: Cardiology Authors: Jozef Bartunek, Andre Terzic, Beth A. Davison, Atta Behfar, Ricardo Sanz ‐Ruiz, Wojciech Wojakowski, Warren Sherman, Guy R. Heyndrickx, Marco Metra, Gerasimos S. Filippatos, Scott A. Waldman, John R. Teerlink, Timothy D. Henry, Bernard J. G Tags: Original Research Article Source Type: research

Multi ‐modality machine learning approach for risk stratification in heart failure with left ventricular ejection fraction ≤ 45%
ConclusionsMulti ‐modality assessment is important for risk stratification in HF. A machine learning approach provides additional value for improving outcome prediction. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 23, 2020 Category: Cardiology Authors: Gary Tse, Jiandong Zhou, Samuel Won Dong Woo, Ching Ho Ko, Rachel Wing Chuen Lai, Tong Liu, Yingzhi Liu, Keith Sai Kit Leung, Andrew Li, Sharen Lee, Ka Hou Christien Li, Ishan Lakhani, Qingpeng Zhang Tags: Original Research Article Source Type: research