An altered plasma lipidome –phenome network characterizes heart failure with preserved ejection fraction
ConclusionsWe did not find significant direct associations between plasma lipidomic parameters and HFpEF and therefore could not conclude that any specific lipids are biomarkers of HFpEF. The validation in larger cohort is needed to confidently conclude the absence of first-order associations. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 20, 2024 Category: Cardiology Authors: Nina Jovanovic,
Anna Foryst ‐Ludwig,
Christian Klose,
Cristina Rozados da Conceicao,
Lina Alasfar,
Till Birkner,
Sofia K. Forslund,
Ulrich Kintscher,
Frank Edelmann Tags: Original Article Source Type: research
Can right ventricular endomyocardial biopsy predict left ventricular fibrosis beforehand in dilated cardiomyopathy?
ConclusionsThe fibrosis observed in RV-EMB positively correlated with the extent of fibrosis in the LV of excised hearts in patients with DCM. The study findings may help predict LV fibrosis, considered a prognostic factor of DCM through relatively accessible biopsy techniques. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Kisaki Amemiya,
Taka ‐aki Matsuyama,
Hatsue Ishibashi‐Ueda,
Yoshiaki Morita,
Manabu Matsumoto,
Keiko Ohta‐Ogo,
Yoshihiko Ikeda,
Yasumasa Tsukamoto,
Norihide Fukushima,
Satsuki Fukushima,
Tomoyuki Fujita,
Kinta Hatakeyama Tags: Original Article Source Type: research
Interferon ‐regulatory factor‐1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14‐3‐3γ axis
ConclusionThe IRF1-mediated VEGFA/14-3-3 γ signalling pathway promotes BVZ-induced myocardial injury. Our study provides evidence for potentially new target genes for the treatment of myocardial injury. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Xuan ‐Ying Chen,
Meng‐Qi Xie,
Wei‐Lin Huang,
Wen‐Juan Li,
Yan‐Ni Lv,
Xiao‐Ping Peng Tags: Original Article Source Type: research
Pre ‐emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm
ConclusionsThe HeartLogic ™ France Cohort Study will provide robust real-world data in a cohort of HF patients managed with the HeartLogic™ algorithm allowing pre-emptive treatment of heart failure exacerbations. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Rodrigue Garcia,
Daniel Gras,
Jacques Mansourati,
Pascal Defaye,
Arnaud Bisson,
Serge Boveda,
Estelle Gandjbakhch,
Matthieu Gras,
Jean ‐Pierre Gueffet,
Caroline Himbert,
Peggy Jacon,
Pierre Khattar,
Benoit Lequeux,
Anthony Li,
Vincent Mans Tags: Study Design Source Type: research
Urea nitrogen ‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction
ConclusionsA higher BAR was an independent predictor for LVA formation in STEMI patients with primary PCI. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Kai Zhang,
Lihong Yang,
Xiaoguang Wu,
Xiaohui Zheng,
Yonghui Zhao Tags: Original Article Source Type: research
LncRNA SNHG1 alleviates myocardial ischaemia –reperfusion injury by regulating the miR‐137‐3p/KLF4/TRPV1 axis
ConclusionsThese results showed that lncRNA SNHG1 assuaged cardiomyocyte pyroptosis during MIRI progression by regulating the KLF4/TRPV1/AKT axis through sponging miR-137-3p. Our findings may provide novel therapeutic targets for MIRI. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Ruo ‐Fu Tang,
Wen‐Jing Li,
Yun Lu,
Xuan‐Xuan Wang,
Su‐Yu Gao Tags: Original Article Source Type: research
Identification of heart failure hospitalization from NHS Digital data: comparison with expert adjudication
ConclusionsNHS Digital data were not able to accurately identify HHF and should not be used in isolation for this purpose. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Fardad Soltani,
Joshua Bradley,
Antonio Bonandi,
Nicholas Black,
John P. Farrant,
Adam Pailing,
Christopher Orsborne,
Simon G. Williams,
Erik B. Schelbert,
Susanna Dodd,
Richard Williams,
Niels Peek,
Matthias Schmitt,
Theresa McDonagh,
Chris Tags: Original Article Source Type: research
Application of an echocardiographic index to characterize right ventricular –pulmonary arterial coupling in heart failure
AbstractHeart failure (HF), with its high morbidity and mortality, remains a global public health issue. Right ventricular (RV) dysfunction is a sign of deterioration in the natural history of HF, and a thorough evaluation of the relationship between RV contractility and its afterload through RV –pulmonary arterial (RV–PA) coupling can aid in accurately assessing overall RV function. The ratio of RV end-systolic elastance (Ees) to pulmonary arterial elastance (Ea) invasively measured by right heart catheterization served as the gold standard for evaluating RV–PA coupling. An echocardi ographic index termed tricuspid ...
Source: ESC Heart Failure - January 17, 2024 Category: Cardiology Authors: Xin Chen,
Peige Zhang,
Jie Lou,
Ruohan Zhao,
Siyi Zhang,
Mingxing Xie,
Qing Lv Tags: Review Source Type: research
Impact of mental disorders on unplanned readmissions for congestive heart failure patients: a population ‐level study
ConclusionsCHF patients who had a mental disorder diagnosis in the past 12 months are more likely to be readmitted compared with those without a mental disorder diagnosis. CHF patients with frailty and a mental disorder have the highest probability of readmission. Addressing mental health care services in CHF patient's discharge plan could potentially assist reduce unpla nned readmissions. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 17, 2024 Category: Cardiology Authors: Zhisheng Sa,
Tim Badgery ‐Parker,
Janet C. Long,
Jeffrey Braithwaite,
Martin Brown,
Jean‐Frederic Levesque,
Diane E. Watson,
Johanna I. Westbrook,
Rebecca Mitchell Tags: Original Article Source Type: research
Medicines optimization prior to discharge in patients admitted to hospital with heart failure
ConclusionsMost patients admitted for heart failure are eligible for initiation of life-prolonging medications prior to discharge. A hospital admission may be a common missed opportunity to improve treatment for patients with HeFREF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 17, 2024 Category: Cardiology Authors: Joseph J. Cuthbert,
Oliver I. Brown,
Pierpaolo Pellicori,
Karen Dobbs,
Jeanne Bulemfu,
Syed Kazmi,
Ioanna Sokoreli,
Steffan C. Pauws,
Jarno M. Riistama,
John G.F. Cleland,
Andrew L. Clark Tags: Original Article Source Type: research
Impact of rapid sequential combination therapy on distinct haemodynamic measures in newly diagnosed pulmonary arterial hypertension
ConclusionsRapid sequential combination therapy with PDE5i/sGC-S and ERA substantially ameliorates cardiopulmonary haemodynamics at early follow-up in patients without, and to a lesser extent, with cardiovascular co-morbidities. This occurs in line with improvements of clinical parameters and risk status. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 16, 2024 Category: Cardiology Authors: Tilmann Kramer,
Phillip Nattmann,
Felix Gerhardt,
Patrycja Stafiej,
Daniel Dumitrescu,
Henrik ten Freyhaus,
Max Wi ßmüller,
Christopher Hohmann,
Stephan Baldus,
Stephan Rosenkranz Tags: Original Article Source Type: research
Improved heart function and cardiac remodelling following sacubitril/valsartan in acute coronary syndrome with HF
ConclusionsThe cardiac function is improved and cardiac remodelling is reversed significantly after treatment of S/V in ACS patients with reduced left ventricular ejection fraction after PCI, and the improvement is more obvious than the routine group. There is a significant negative correlation between the change in LVEF and the changes in NT-proBNP, LVMI, LVEDVI, and LVESVI. The increase of LVEF and the decrease of LVEDVI and LVESVI are protective factors to improve the prognosis. Patients with myocardial infarction and reduced left ventricular ejection fraction might benefit more from the initiation of S/V as first-line ...
Source: ESC Heart Failure - January 16, 2024 Category: Cardiology Authors: Henan Liu,
Yongkang Su,
Jian Shen,
Yang Jiao,
Ying Li,
Bing Liu,
Xiaoling Hou,
Qinhua Jin,
Yundai Chen,
Zhijun Sun,
Qing Xi,
Bin Feng,
Zhenhong Fu Tags: Original Article Source Type: research
Giant cell myocarditis with prolonged cardiac standstill after drug ‐induced hypersensitivity syndrome: a case report
We present a case of a 28-year-old woman who developed GCM during steroid tapering after DIHS. She went into continuous cardiac standstill but survived for 74 days under BiVAD support. Our case is noteworthy because the histopathologic specimens obtained on three occasions contributed to the diagnosis of this particular condition over time. We also reviewed previous literature on concomitant cases of GCM and DIHS. We found that two are potentially assoc iated and most cases of GCM occur within 3 months of DIHS during steroid tapering. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 15, 2024 Category: Cardiology Authors: Ryohei Ono,
Hiroki Kohno,
Sae Kaminota,
Kaoruko Aoki,
Hirotoshi Kato,
Togo Iwahana,
Takanori Aihara,
Masayuki Ota,
Goro Matsumiya,
Yoshio Kobayashi Tags: Case Report Source Type: research
Autopsy findings in cases of fatal COVID ‐19 vaccine‐induced myocarditis
AbstractCOVID-19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID-19 vaccines and death from myocarditis using post-mortem analysis. We performed a systematic review of all published autopsy reports involving COVID-19 vaccination-induced myocarditis through 3 July 2023. All autopsy studies that include COVID-19 vaccine-induced myocarditis as a possible cause of death were included. Causality in each case was assessed by three independent physicians with cardiac pathology experience and expertise. We initiall...
Source: ESC Heart Failure - January 15, 2024 Category: Cardiology Authors: Nicolas Hulscher,
Roger Hodkinson,
William Makis,
Peter A. McCullough Tags: Review Source Type: research
Natural history and outcomes in paediatric RASopathy ‐associated hypertrophic cardiomyopathy
ConclusionsThese findings highlight a distinct category of patients with Noonan-like syndrome with a milder HCM phenotype but significantly worse survival and identify potential predictors of adverse outcome in patients with RASopathy-related HCM. (Source: ESC Heart Failure)
Source: ESC Heart Failure - January 14, 2024 Category: Cardiology Authors: Olga Boleti,
Gabrielle Norrish,
Ella Field,
Kathleen Dady,
Kim Summers,
Gauri Nepali,
Vinay Bhole,
Orhan Uzun,
Amos Wong,
Piers E. F. Daubeney,
Graham Stuart,
Precylia Fernandes,
Karen McLeod,
Maria Ilina,
Muhammad Najih Liaqath Ali,
Tara B Tags: Original Article Source Type: research
