Design and baseline characteristics of SALT ‐HF trial: hypertonic saline therapy in ambulatory heart failure
ConclusionsSALT-HF trial randomized 167 ambulatory patients with WHF and will determine whether an infusion of hypertonic saline therapy plus furosemide increases diuresis and improves decongestion compared to equivalent furosemide administration alone. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 22, 2024 Category: Cardiology Authors: M. Cobo Marcos, J. Com ín‐Colet, R. de la Espriella, J. Rubio Gracia, J. L. Morales‐Rull, I. Zegrí, P. Llacer, P. Diez‐Villanueva, S. Jiménez‐Marrero, J. de Juan Bagudá, C. Ortiz Cortés, J. Goirigolzarri‐Artaza, J. M. García‐ Tags: Study Design Source Type: research

Cardiac magnetic resonance imaging in heart transplant recipients with biopsy ‐negative graft dysfunction
ConclusionsBiopsy-negative GD occurs with and without LGE when assessed by CMR, indicative of possible rejection/inflammation occurring only in a subset of patients. Irrespective of LGE, LVEF improvement occurs in most GD patients, suggesting that other neurohormonal or immunomodulatory mechanisms may also contribute to GD development. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 21, 2024 Category: Cardiology Authors: Senthil Anand, Hilmi Alnsasra, Lisa M. LeMond, Sanskriti Shrivastava, Rabea Asleh, Andrew Rosenbaum, Semaan Kobrossi, Akanksha Mohananey, Katie Murphy, Byron H. Smith, Sudhir Kushwaha, David E. Steidley, Alfredo Clavell, Phillip Young, Navee Tags: Original Article Source Type: research

Impact of the operative technique on mid ‐ and long‐term results following paediatric heart transplantation
ConclusionsPaediatric heart transplantation using bicaval technique results similar long-term survival compared with the biatrial technique. The incidence of atrial rhythm disorders was significantly higher in the biatrial group, requiring a higher frequency of pacemaker implantation in this group. As a results, the bicaval technique has replaced the biatrial technique in our centre. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 21, 2024 Category: Cardiology Authors: L. Lily Rosenthal, Carola Grinninger, Robert Dalla Pozza, Marcus Fischer, Linda Zimmerling, Sarah M. Ulrich, Fabian A. Kari, Nikolaus A. Haas, Sebastian Michel, J ürgen Hörer, Christian Hagl Tags: Original Article Source Type: research

Heart failure during acute coronary syndrome and the long ‐term cancer risk: the ABC‐9 Study on heart disease
ConclusionsAn inverse association between baseline HF and long-term cancer risk has been observed among the ABC Study on heart disease patients who were followed for 24  years after ACS. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 20, 2024 Category: Cardiology Authors: Heba T. Mahmoud, Giuseppe Berton, Rocco Cordiano, Rosa Palmieri, David Merotto, Francesco Menegon Tags: Original Article Source Type: research

Chlorogenic acid attenuates cardiac hypertrophy via up ‐regulating Sphingosine‐1‐phosphate receptor1 to inhibit endoplasmic reticulum stress
ConclusionsCGA treatment attenuated ISO-induced ERS and cardiac hypertrophy by activating the AMPK/SIRT1 pathway via modulation of S1pr1. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 19, 2024 Category: Cardiology Authors: Ping Ping, Ting Yang, Chaoxue Ning, Qingkai Zhao, Yali Zhao, Tao Yang, Zhitao Gao, Shihui Fu Tags: Original Article Source Type: research

Distinct myocardial triglyceride lipolysis pathways in primary and idiopathic triglyceride deposit cardiomyovasculopathy
(Source: ESC Heart Failure)
Source: ESC Heart Failure - February 19, 2024 Category: Cardiology Authors: Yoshihiko Ikeda, Mikio Shiba, Hiroyuki Yamamoto, Tomonori Itoh, Takahiro Okumura, Yusuke Nakano, Hideyuki Miyauchi, Tomomi Ide, Sohsuke Yamada, Hiroyuki Hao, Seiya Kato, Ken ‐ichi Hirano, On behalf of the Japan TGCV study group Tags: Letter to the Editor Source Type: research

Pregnancy and cardiac maternal outcomes in women with inherited cardiomyopathy: interest of the CARPREG II risk score
ConclusionsPregnancy in women with inherited cardiomyopathy carries a high risk of maternal cardiovascular complications. CARPREG II is the most efficient predictor of cardiovascular complications in this population. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 16, 2024 Category: Cardiology Authors: Thomas Wallet, Lise Legrand, Richard Isnard, Estelle Gandjbakhch, Fran çoise Pousset, Julie Proukhnitzky, Marc Dommergues, Jacky Nizard, Philippe Charron Tags: Original Article Source Type: research

Tyrosine to threonine ratio was related to heart failure with reduced or mildly reduced ejection fraction
ConclusionsCirculating elevated Tyr/Thr ratio confer an increased risk for the presence of HF and poor prognosis. Tyr/Thr index outweighs FR index in predicting HF occurrence or CV death. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 16, 2024 Category: Cardiology Authors: Qing Fen Zhou, Fan Yang, Yang Dai, Shuai Chen, Feng Ru Zhang, Lin Lu, Qiu Ya Lu Tags: Original Article Source Type: research

Prognostic impact of residual pulmonary congestion assessed by remote dielectric sensing system in patients admitted for heart failure
ConclusionsElevated ReDS ratios detected during the index hospitalization could serve as a promising prognostic indicator in HF patients admitted for treatment. The clinical ramifications of ReDS-guided HF management warrant validation in subsequent studies. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 15, 2024 Category: Cardiology Authors: Toshihide Izumida, Teruhiko Imamura, Takatoshi Koi, Masaki Nakagaito, Hiroshi Onoda, Shuhei Tanaka, Ryuichi Ushijima, Naoya Kataoka, Makiko Nakamura, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa Tags: Original Article Source Type: research

Guideline ‐directed medical therapy assessment in heart failure patients undergoing percutaneous mitral valve repair
ConclusionsThis study demonstrates the utility of a simple GDMT scoring system for assessing the adequacy of GDMT in HFrEF patients with relevant SMR undergoing M-TEER. The GDMT score has potential applications in guiding the design of future clinical trials and aiding clinical decision-making processes. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 14, 2024 Category: Cardiology Authors: Karl ‐Patrik Kresoja, Marianna Adamo, Karl‐Phillipp Rommel, Lukas Stolz, Nicole Karam, Cristina Giannini, Bruno Melica, Ralph Stephan von Bardeleben, Christian Butter, Patrick Horn, Fabien Praz, Daniel Kalbacher, Christos Iliadis, Holger Tags: Short Communication Source Type: research

Tricuspid annular disjunction with varying degrees of tricuspid regurgitation in the setting of Takotsubo syndrome
AbstractTricuspid annular disjunction (TAD) is concomitant in approximately half of mitral annular disjunction (MAD) cases. Here we report a case of echocardiographically isolated TAD detected during Takotsubo syndrome (TTS) complicated by a transient aggravation of tricuspid regurgitation. An 87-year-old female was admitted at the emergency department with ST segment elevation. Coronary angiography findings were consistent with TTS. Transthoracic echocardiography (TTE) showed a left ventricular apical aneurysm with incidental finding of TAD with ‘torrential’ tricuspid regurgitation. Importantly, no concomitant MAD was...
Source: ESC Heart Failure - February 13, 2024 Category: Cardiology Authors: Benjamin Gaylard, Angela Monta ño‐Krawczuk, Kristina Haugaa, Magnus Bäck Tags: Case Report Source Type: research

Takotsubo syndrome and vaccines: a systematic review
ConclusionsTTS is a rare but potentially life-threatening complication of vaccination. Typical TTS symptoms such as chest pain and dyspnoea should be considered alarming symptoms, though nonspecific symptoms are common. The risks of such rare adverse events should be balanced against the risks of infection. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 12, 2024 Category: Cardiology Authors: Chenlin Li, Pengyang Li, Bharath Peddibhotla, Catherine Teng, Ao Shi, Xiaojia Lu, Peng Cai, Qiying Dai, Bin Wang Tags: Short Communication Source Type: research

Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction
ConclusionsCA 125 levels were significantly higher in HFpEF patients compared with controls matched for age and sex and were associated with markers of congestion and cardiac fibrosis. CA 125 levels were a strong and independent predictor of HF hospitalization in HFpEF patients. These data suggest a potential value of CA 125 as a biomarker for staging and risk prediction in HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 10, 2024 Category: Cardiology Authors: Nassiba Menghoum, Maria Chiara Badii, Matthieu Deltombe, Sibille Lejeune, Clotilde Roy, David Vancraeynest, Agnes Pasquet, Bernhard L. Gerber, Sandrine Horman, Damien Gruson, Christophe Beauloye, Anne ‐Catherine Pouleur Tags: Original Article Source Type: research

A novel likely pathogenic homozygous RBCK1 variant in dilated cardiomyopathy with muscle weakness
ConclusionsOur study offers novel findings indicating anRBCK1 variant in individuals of Iranian ancestry presenting with DCM leading to heart transplantation and myopathy without immunodeficiency or auto-inflammation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 9, 2024 Category: Cardiology Authors: MohammadHossein MozafaryBazargany, Shiva Esmaeili, Mahshid Hesami, Golnaz Houshmand, Mohamad Mahdavi, Majid Maleki, Samira Kalayinia Tags: Original Article Source Type: research

Left ventricular unloading and venting in veno ‐arterial extracorporeal membrane oxygenation: the importance of cardiogenic shock aetiology in guiding treatment strategies
(Source: ESC Heart Failure)
Source: ESC Heart Failure - February 8, 2024 Category: Cardiology Authors: Luca Baldetti, Guglielmo Gallone Tags: Editorial Source Type: research