Cardiac sympathetic nerve activity trends after renal denervation in heart failure with preserved ejection fraction

AbstractThis case report describes the application of ultrasound renal denervation (uRDN) using the Paradise System in a patient with heart failure with preserved ejection fraction. Initially, the cardiac sympathetic nerve activity of the patient exhibited a late heart/mediastinum (H/M) ratio of 2.00 and a washout rate of 66.0% by cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy. Subsequently, the patient underwent transfemoral uRDN targeting the left, right upper, and right lower renal arteries. At the 6  month follow-up, no significant change was observed in123I-MIBG findings; however, the estimated stressed blood volume (eSBV) decreased from 1722 to 1029  mL/70 kg. At 18 months,123I-MIBG findings improved, with the late H/M ratio reaching 2.76 and the washout rate decreasing to 43.1%. This case report highlights the potential of uRDN in reducing eSBV within 6  months and subsequently improving cardiac sympathetic nerve activity at the 18 month follow-up.

Source: ESC Heart Failure - April 25, 2024 Category: Cardiology Authors: Tatsuya Shiraki, Hiroya Mizuno, Takuya Kishi, Masanori Asakura, Hidetsugu Asanoi, Yoshio Yasumura, Yasushi Sakata Tags: Case Report Source Type: research