Regional differences and coronary microvascular dysfunction in heart failure with preserved ejection fraction
ConclusionsDespite regional differences in clinical characteristics, CMD was present in the majority of patients with HFpEF across different regions of the world with the lowest prevalence in the United States. This difference was explained by differences in patient characteristics. CMD could be a common therapeutic target across regions. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 3, 2023 Category: Cardiology Authors: Mikael Erhardsson, Ulrika Ljung Fax én, Ashwin Venkateshvaran, Sara Svedlund, Antti Saraste, Maria Lagerström Fermer, Li‐Ming Gan, Sanjiv J. Shah, Jasper Tromp, Carolyn SP Lam, Lars H. Lund, Camilla Hage Tags: Short Communication Source Type: research

A novel ‘shunt fraction’ method to derive native cardiac output during liberation from central VA ECMO
This report describes a novel ‘shunt fraction’ method to calculate intrinsic cardiac output in central (right atrial-to-aorta) ECMO. The physiological basis of this ‘shunt fraction’ method is described, followed by the case presentation that details the clinical application of this method of quantifying intrinsic cardiac output to guide weaning and liberation from central VA ECMO. (Source: ESC Heart Failure)
Source: ESC Heart Failure - November 2, 2023 Category: Cardiology Authors: Hoong Sern Lim Tags: Case Report Source Type: research

B ‐cell maturation antigen chimeric antigen receptor‐T therapy alleviated heart failure in patients with multiple myeloma
AbstractPatients with multiple myeloma (MM) are likely to achieve poor therapeutic response when organs are involved. We produced anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR)-T cells, which are in a trial for patients with relapsed/refractory MM. One enrolled patient developed severe heart failure, highly suspected as light chain cardiac amyloidosis. He exhibited increased N-terminal pro-brain natriuretic peptide with a peak of 32  299 ng/mL and heart failure with an ejection fraction of 30%. Anti-BCMA CAR-T cells were administered following lymphodepletion. The patient achieved cardiac response ...
Source: ESC Heart Failure - November 1, 2023 Category: Cardiology Authors: Yunhong Wang, Ke Zhang, Xiaohui Suo, Ning Meng, Yuanrui Gu, Yilang Qin, Yanxia Tu, Xiaohui Zhang, Guofeng Sun, Jiaojiao Ji, Weichun Wu, Yuqi Cai, Kai Yang, Chenxi Ouyang, Junyuan Qi Tags: Case Report Source Type: research

Hydralazine combined with conventional therapy improved outcomes in severe systolic dysfunction and mitral regurgitation
ConclusionsWhen administered without inadequate preload, combining early up-titration of hydralazine with EBMs improves outcome in patients with severe systolic dysfunction and significant MR, and it is safe and well tolerated. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 28, 2023 Category: Cardiology Authors: Shih ‐Hung Hsiao, Chao‐Sheng Hsiao, Jau‐Wen Shiau, Kuan‐Rau Chiou Tags: Original Article Source Type: research

Severe aortic insufficiency ‐induced cardiogenic shock treated with left atrial VA‐ECMO and emergent valve‐in‐valve TAVR
We present a case of severe rapid-onset bioprosthetic aortic insufficiency-induced cardiogenic shock successfully resuscitated with left atrial VA-ECMO promptly followed by emergent percutaneous valve-in-valve transaortic valve replacement. We discuss the logistics, implications, and associated haemodynamic manifestations in utilizing this strategy for such disease processes. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 27, 2023 Category: Cardiology Authors: Hafez Golzarian, Arielle Thiel, Gerri Hempfling, Michael Otto, Todd Otto, Emily Shappell, Lisa Racer, Denise Martz, Christine M. Recker ‐Herman, Amanda Laird, William C. Cole, John Sirak, Sandeep M. Patel Tags: Case Report Source Type: research

Systemic vascular resistance predicts high ‐output cardiac failure in patients with high‐flow arteriovenous fistula
ConclusionsIn patients with high-flow AV access, low eSVR values obtained through non-invasive Doppler echocardiography were associated with a high rate of HOCF hospitalizations. Therefore, routine eSVR screening in these patients might expedite the diagnosis of HOCF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 27, 2023 Category: Cardiology Authors: Dan ‐Ying Lee, Ting Chen, Wei‐Chieh Huang, Ruey‐Hsing Chou, Cheng‐Hsueh Wu, Chih‐Yu Yang, Chiu‐Yang Lee, Chih‐Ching Lin, Der‐Cherng Tarng Tags: Original Article Source Type: research

Dapagliflozin treatment and cardiovascular outcome in RBP4/TTRVal30Met (transthyretin cardiac amyloidosis) mice
ConclusionsDapagliflozin did not improve cardiovascular prognosis including the progression of heart failure, cardiac inflammation, and pathological changes in ATTR-CA mice compared with placebo. The results of this study were not in support of dapagliflozin's therapeutic effects for ATTR-CA. More pre-clinical and clinical researches to validate these findings and demonstrate the underlying mechanisms are still required. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 26, 2023 Category: Cardiology Authors: Zonglin Li, Fang Lv, Xin Wen, Chengcheng Guo, Li Li, Xiaoling Cai, Chu Lin, Mengqing Zhang, Wenjia Yang, Linong Ji Tags: Original Article Source Type: research

Cavin ‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis
ConclusionsCavin-2 loss suppressed fibroblast trans-differentiation into myofibroblasts through the TGF- β/Smad signalling. The loss of Cavin-2 in cardiac fibroblasts suppresses cardiac fibrosis and may maintain cardiac function. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 24, 2023 Category: Cardiology Authors: Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Masahiro Nishi, Yumika Tsuji, Shinya Tomita, Simon J. Conway, Satoaki Matoba Tags: Original Article Source Type: research

Cardiac reverse remodelling by imaging parameters with recent changes to guideline medical therapy in heart failure
AbstractRecently established heart failure therapies, including sodium glucose co-transporter 2 inhibitors, angiotensin-neprilysin inhibitors, and cardiac resynchronization therapy, have led to both clinical and structural improvements. Reverse remodelling describes the structural and functional responses to therapy and has been shown to correlate with patients' clinical response, acting as a biomarker for treatment success. The introduction of these new therapeutic agents in addition to advances in non-invasive cardiac imaging has led to an expansion in the evaluation and the validation of cardiac reverse remodelling. Met...
Source: ESC Heart Failure - October 24, 2023 Category: Cardiology Authors: Matthew Kodsi, David Makarious, Gary C.H. Gan, Preeti Choudhary, Liza Thomas Tags: Review Source Type: research

MicroRNA ‐30d and ‐483‐3p for bi‐ventricular remodelling and miR‐126‐3p for pulmonary hypertension in advanced heart failure
ConclusionsIn patients with DCM, few miRNAs are co-expressed in serum and tissue: They are related to LV remodelling (miR-30d), post-capillary pulmonary artery pressure (miR-126-3p), and right ventricular remodelling/filling pressures (miR-483-3p). Further studies are needed to confirm their role in diagnosis, prognosis or as therapeutic targets in heart failure with reduced ejection fraction. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 22, 2023 Category: Cardiology Authors: Alessia Gallo, Valentina Agnese, Sergio Sciacca, Cesare Scardulla, Manlio Cipriani, Michele Pilato, Jae K. Oh, Salvatore Pasta, Joseph Maalouf, Pier Giulio Conaldi, Diego Bellavia Tags: Original Article Source Type: research

Cushing's syndrome presenting as non ‐atherosclerotic myocardial infarction and heart failure
AbstractCushing's syndrome is a rare cause of myocardial infarction and heart failure. Herein, we report a female patient who presented acute myocardial infarction and heart failure with reduced ejection fraction. The patient was found to have hypercortisolism secondary to adrenocortical adenoma and responded well to therapy. This case underlines the effects of hypercortisolism on the cardiovascular system. The clinical presentation of this patient is unique because non-atherosclerotic myocardial infarction is rarely reported in Cushing's syndrome patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 19, 2023 Category: Cardiology Authors: Yanming Li, Songqing He, Jing Feng, Sai Ma, Lei Wang Tags: Case Report Source Type: research

D ‐dimer, C‐reactive protein and matrix metalloproteinase 9 for prediction of type A aortic dissection patient survival
ConclusionsCombined measurement of CRP,d-dimer, and MMP9 is associated with 1  year of survival in patients with ATAAD. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 18, 2023 Category: Cardiology Authors: Minjie Huang, Yujie Lian, Zhongyan Zeng, Jiahong Li Tags: Original Article Source Type: research

Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP ‐HF registry
ConclusionsAmong patients with HF and at least one ‘I NEED HELP’ marker for advanced HF, left ventricular EF is still of prognostic value. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 17, 2023 Category: Cardiology Authors: Matteo Pagnesi, Carlo Mario Lombardi, Chiara Tedino, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Marianna Adamo, Filippo Cal ì, Riccardo Maria Inciardi, Daniela Tomasoni, Ferdinando Loiacono, Marta Maccallini, Alessandro Villaschi, Gaia Ga Tags: Original Article Source Type: research

International Physical Activity Questionnaire Short Form and accelerometer ‐assessed physical activity: concurrent validity using six cut‐points in HF patients
ConclusionsModerate to vigorous PA measures using IPAQ-SF and accelerometers are not equivalent, and we do not encourage researchers to use IPAQ-SF alone when assessing PA in HF patients. Moreover, applying personalized collection and processing criteria is important when assessing PA in HF patients. We recommend following the 24  h protocol and selecting cut-points calibrated in patients with cardiovascular diseases. Finally, it is necessary to develop a new tailored questionnaire that considers walking intensity and is adjusted to the current World Health Organisation recommendations, which use non-bouted metrics. (Sour...
Source: ESC Heart Failure - October 16, 2023 Category: Cardiology Authors: Carles Blasco ‐Peris, Vicente Climent‐Paya, Tomas Vetrovsky, María I. García‐Álvarez, Agustín Manresa‐Rocamora, Vicente J. Beltrán‐Carrillo, José Manuel Sarabia Tags: Original Article Source Type: research

Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy
ConclusionsWe identified a patient with hATTR-CM who possesses a rare TTRA81V mutation solely associated with cardiac complications. The slightly reduced kinetic stability of this mutation indicates its late-onset nature and contributes to the gradual progression of the disease. (Source: ESC Heart Failure)
Source: ESC Heart Failure - October 13, 2023 Category: Cardiology Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu Tags: Original Article Source Type: research