Ubiquitination in rheumatoid arthritis
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Tapan Behl, Swati Chadha, Monika Sachdeva, Arun Kumar, Abdul Hafeez, Vineet Mehta, Simona Bungau (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Yanning Li, Jun Zhou, Jiasheng Qiu, Zudong Huang, Weiwei Wang, Ping Wu, Aiwen Feng (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Different combinations of GABA, BMP7, and Activin A induced the in vitro differentiation of rat pancreatic ductal stem cells into insulin-secreting islet-like cell clusters
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Lang Guan Cun, Muhammad Waseem Ghani, Zhao Yi, Wu Jiang, Li Ye, Liu Bin, Muhammad Waseem Birmani, An Lilong, Xiao Mei (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-β/MAPK signaling pathway in renal fibrosis
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Bochuan Deng, Wenle Yang, Dan Wang, Lu Cheng, Lili Bu, Jing Rao, Jianfeng Zhang, Junqiu Xie, Bangzhi Zhang (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Baicalein ameliorates ionizing radiation-induced injuries by rebalancing gut microbiota and inhibiting apoptosis
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Meifang Wang, Yinping Dong, Jing Wu, Hongyan Li, Yuanyang Zhang, Saijun Fan, Deguan Li (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25–35 treated BV-2 cells
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Heng-bing Zu, Xin-ying Liu, Kai Yao (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Nosayba Al-Azzam, Lina Elsalem (Source: Life Sciences)
Source: Life Sciences - September 19, 2020 Category: Biology Source Type: research

Advanced glycation end-products and advanced oxidation protein products levels are correlates of duration of type 2 diabetes
Publication date: Available online 15 September 2020Source: Life SciencesAuthor(s): Firouzeh Heidari, Soghra Rabizadeh, Armin Rajab, Farrokh Heidari, Marjan Mouodi, Hossien Mirmiranpour, Alireza Esteghamati, Manouchehr Nakhjavani (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression
Publication date: Available online 14 September 2020Source: Life SciencesAuthor(s): Sevda Salimifard, Fariba Karoon Kiani, Farzaneh Sadat Eshaghi, Sepideh Izadi, Kolsoom Shahdadnejad, Ali Masjedi, Morteza Heydari, Armin Ahmadi, Mohammad Hojjat-Farsangi, Hadi Hassannia, Hamed Mohammadi, Samaneh Boroumand-Noughabi, Mohammad Reza Keramati, Farhad Jadidi-Niaragh (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

Application and reflection of genomic scar assays in evaluating the efficacy of platinum salts and PARP inhibitors in cancer therapy
Publication date: Available online 14 September 2020Source: Life SciencesAuthor(s): Rui Gou, Hui Dong, Bei Lin (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

A novel selective histone deacetylase I inhibitor CC-4a activates latent HIV-1 through NF-κB pathway
Publication date: Available online 14 September 2020Source: Life SciencesAuthor(s): Wanzhen Lu, Chan Yang, Xinfeng Xu, Chen Chen, Xuben Hou, Hao Fang, Shuwen Liu (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

SARS-CoV-2 and coagulation disorders in different organs
Publication date: Available online 15 September 2020Source: Life SciencesAuthor(s): Sathishkumar Vinayagam, Kamaraj Sattu (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

Sex-specific susceptibility to type 2 diabetes mellitus and preventive effect of linalyl acetate
Publication date: 1 November 2020Source: Life Sciences, Volume 260Author(s): You Kyoung Shin, Yu Shan Hsieh, A Young Han, Soonho Kwon, Purum Kang, Geun Hee Seol (Source: Life Sciences)
Source: Life Sciences - September 16, 2020 Category: Biology Source Type: research

Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo
Publication date: Available online 13 September 2020Source: Life SciencesAuthor(s): Shimaa Khaled, Mirhan N. Makled, Manar A. Nader (Source: Life Sciences)
Source: Life Sciences - September 15, 2020 Category: Biology Source Type: research

IL-27 along with IL-28B ameliorates the pulmonary redox impairment, inflammation and immunosuppression in benzo(a)pyrene induced lung cancer bearing mice
Publication date: 1 November 2020Source: Life Sciences, Volume 260Author(s): Debabrata Majumder, Rahul Debnath, Debasish Maiti (Source: Life Sciences)
Source: Life Sciences - September 15, 2020 Category: Biology Source Type: research

Antimicrobial peptides – Advances in development of therapeutic applications
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Huy Xuan Luong, Tung Truong Thanh, Tuan Hiep Tran (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Neuroprotection of benzoinum in cerebral ischemia model rats via the ACE-AngI-VEGF pathway
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Hai Chen, Mihong Ren, Hongyan Li, Qian Xie, Rong Ma, Yong Li, Xiaoqing Guo, Jian Wang, Daoyin Gong, Tian Gao (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Erika Csekes, Máté Vágvölgyi, Attila Hunyadi, Lucia Račková (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Mucosal characteristics vary across developmental stages in the small intestine of C57BL/6J mice
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Christine J. Park, Matthew P. Shaughnessy, Robert A. Cowles (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

LncRNA ARFRP1 knockdown inhibits LPS-induced the injury of chondrocytes by regulation of NF-κB pathway through modulating miR-15a-5p/TLR4 axis.
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Guangcheng Zhang, Qing Zhang, Juan Zhu, Jiazhu Tang, Mingjun Nie (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement
Publication date: Available online 13 September 2020Source: Life SciencesAuthor(s): Mahsa Sadeghi-Adl, Mitra-Sadat Sadat-Shirazi, Faezeh Shahini, Ardeshir Akbarabadi, Solmaz Khalifeh, Shokoofeh Borzabadi, Mohammad Nasehi, Mohammad-Reza Zarrindast (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Amira M. Abo-Youssef, Hassan Afify, Amany A. Azouz, Hanaa M. Abdel-Rahman, Ashraf B. Abdel-Naim, Shady Allam (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

A novel lncRNA–miRNA–mRNA competitive endogenous RNA network for uveal melanoma prognosis constructed by weighted gene co-expression network analysis
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Huan Yu, Yaqi Cheng, Weihua Li, Zhiquan Li, Peixin Wu, Sujuan Qiu, Baozhu Zeng, Bing Huang (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Yujiro Hattori, Hirotaka Ishii, Shigeyuki Tahara, Akio Morita, Hitoshi Ozawa (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Yaru Zhang, Xiaojiang Liu, Min Yu, Minmin Xu, Yaping Xiao, Wenyu Ma, Lu Huang, Xuegang Li, Xiaoli Ye (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Establishment of an immune microenvironment-based prognostic predictive model for gastric cancer
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Luying Wan, Nian Tan, Nianhai Zhang, Xianhe Xie (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Development and characterization of a mouse model of duodenogastric reflux
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Fuhai Ma, Yiming Ma, Liang Cui, Xinhua Zhao, Bingzhi Wang, Liyan Xue, Hongying Wang, Yantao Tian (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Yangmin Zhao, Yunxiao Gan, Gewei Xu, Kouzhen Hua, Dandan Liu (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Mohamed K. Abdel-Rafei, Noura M. Thabet (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Identification of stool miR-135b-5p as a non-invasive diaognostic biomarker in later tumor stage of colorectal cancer
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Li Li, Aili Wang, Min Cai, Minsi Tong, Fengtao Chen, Ling Huang (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Subclinical elevated B-type Natriuretic Peptide (BNP) indicates endothelial dysfunction contributing to hypoxia susceptibility in healthy individuals
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Rahul Khatri, Rajinder K. Gupta, Praveen Vats, Vishal Bansal, Anand Kumar Yadav, Prasanna K. Reddy, Abhishek Bharadwaj, Pooja Chaudhary, Shivani Sharma, Amir Chand Bajaj, Padma Deskit, Deepak Dass, Thiruthara P. Baburaj, Shashi Bala Singh, Bhuvnesh Kumar (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Vivek Kumar Sharma, Thakur Gurjeet Singh (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

CircATP2B4 promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the miR-223/ATR axis
Publication date: Available online 12 September 2020Source: Life SciencesAuthor(s): Junling Guo, Lei Zhang, Lanfeng Lian, Meihua Hao, Songhu Chen, Yan Hong (Source: Life Sciences)
Source: Life Sciences - September 13, 2020 Category: Biology Source Type: research

Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating AdipoR1 and TGF-β1 expression in rats
Publication date: Available online 10 September 2020Source: Life SciencesAuthor(s): Sarawoot Bunbupha, Kwanjit Apaijit, Putcharawipa Maneesai, Patoomporn Prasarttong, Poungrat Pakdeechote (Source: Life Sciences)
Source: Life Sciences - September 12, 2020 Category: Biology Source Type: research

Hypoxia aggravates non-alcoholic fatty liver disease in presence of high fat choline deficient diet: A pilot study
Publication date: Available online 10 September 2020Source: Life SciencesAuthor(s): Soumalya Sarkar, Sankarsan Bhattacharya, Md. Jahangir Alam, Rajni Yadav, Sanjay K. Banerjee (Source: Life Sciences)
Source: Life Sciences - September 12, 2020 Category: Biology Source Type: research

New insight on possible vaccine development against SARS-CoV-2
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Sundas Nasir Chaudhry, Abu Hazafa, Muhummad Mumtaz, Ume Kalsoom, Saima Abbas, Amna Kainaat, Shahid Bilal, Nauman Zafar, Aleena Siddique, Ayesha Zafar (Source: Life Sciences)
Source: Life Sciences - September 12, 2020 Category: Biology Source Type: research

Bone marrow mesenchymal stem cells ameliorated kidney fibrosis by attenuating TLR4/NF-κB in diabetic rats
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Liya Lin, Hefeng Lin, Daijuanru Wang, Zeying Bao, Huabo Cai, Xiaoming Zhang (Source: Life Sciences)
Source: Life Sciences - September 12, 2020 Category: Biology Source Type: research

Palmatine regulates bile acid cycle metabolism and maintains intestinal flora balance to maintain stable intestinal barrier
Publication date: Available online 11 September 2020Source: Life SciencesAuthor(s): Yayuan Ning, Fei Xu, Rui Xin, Fang Yao (Source: Life Sciences)
Source: Life Sciences - September 12, 2020 Category: Biology Source Type: research

Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway
Publication date: Available online 9 September 2020Source: Life SciencesAuthor(s): Le Fang, Hongtao Chen, Renyi Kong, Jun Que (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

Niacin inhibits the synthesis of milk fat in BMECs through the GPR109A-mediated downstream signalling pathway
Publication date: Available online 9 September 2020Source: Life SciencesAuthor(s): Jiaxin Wang, Yu Cao, Shoupeng Fu, Wen Li, Yusong Ge, Ji Cheng, Juxiong Liu (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

Parameters predicting COVID-19-induced myocardial injury and mortality
Publication date: Available online 9 September 2020Source: Life SciencesAuthor(s): G.D. Duerr, A. Heine, M. Hamiko, S. Zimmer, J.A. Luetkens, J. Nattermann, G. Rieke, A. Isaak, J. Jehle, S.A.E. Held, J.C. Wasmuth, M. Wittmann, C.P. Strassburg, P. Brossart, M. Coburn, H. Treede, G. Nickenig, C. Kurts, M. Velten (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

SETD1A augments sorafenib primary resistance via activating YAP in hepatocellular carcinoma
Publication date: Available online 10 September 2020Source: Life SciencesAuthor(s): Jugang Wu, Hongjuan Chai, Feng Li, Qing Ren, Yan Gu (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

A robust nine-gene prognostic signature associated with tumour doubling time for hepatocellular carcinoma
Publication date: Available online 10 September 2020Source: Life SciencesAuthor(s): Junyu Huo, Liqun Wu, Yunjin Zang (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

Oroxylin A reversed Fibronectin-induced glioma insensitivity to Temozolomide by suppressing IP3R1/AKT/β-catenin pathway
Publication date: Available online 10 September 2020Source: Life SciencesAuthor(s): Youxiang Ding, You Zhou, Zhaohe Li, Heng Zhang, Yue Yang, Hongkun Qin, Qingxiang Xu, Li Zhao (Source: Life Sciences)
Source: Life Sciences - September 10, 2020 Category: Biology Source Type: research

A cross talk between the immunization and edible vaccine: Current challenges and future prospects
Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Ankit Sahoo, Ashok Kumar Mandal, Khusbu Dwivedi, Vikas Kumar (Source: Life Sciences)
Source: Life Sciences - September 9, 2020 Category: Biology Source Type: research

Cardiac function and tolerance to ischemia/reperfusion injury in a rat model of polycystic ovary syndrome during the postmenopausal period
Publication date: Available online 7 September 2020Source: Life SciencesAuthor(s): Mahsa Noroozzadeh, Mohammad Reza Raoufy, Razieh Bidhendi Yarandi, Farzaneh Faraji Shahrivar, Naghmeh Moghimi, Fahimeh Ramezani Tehrani (Source: Life Sciences)
Source: Life Sciences - September 7, 2020 Category: Biology Source Type: research

Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling
Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Anuj Kumar Singh, Nand Kishor Roy, Devivasha Bordoloi, Ganesan Padmavathi, Kishore Banik, Amrita Devi Khwairakpam, Ajaikumar B. Kunnumakkara, Piruthivi Sukumar (Source: Life Sciences)
Source: Life Sciences - September 7, 2020 Category: Biology Source Type: research

Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level
Publication date: Available online 5 September 2020Source: Life SciencesAuthor(s): Wenmin Song, Kai Gao, Panhao Huang, Zizhao Tang, Fangqin Nie, Sujie Jia, Ren Guo (Source: Life Sciences)
Source: Life Sciences - September 7, 2020 Category: Biology Source Type: research

ABCA1 plays an anti-inflammatory role by affecting TLR4 at the feto–maternal interface
Publication date: Available online 5 September 2020Source: Life SciencesAuthor(s): Ning Ding, Na Liu, Lei Yang, Xiaoyan Han, Li Lin, Yan Long (Source: Life Sciences)
Source: Life Sciences - September 7, 2020 Category: Biology Source Type: research

G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes
Publication date: Available online 6 September 2020Source: Life SciencesAuthor(s): Bing Li, Xiaotong Wang, Ming Yu, Ping Yang, Wei Wang (Source: Life Sciences)
Source: Life Sciences - September 7, 2020 Category: Biology Source Type: research