Asiatic acid protects differentiated PC12 cells from Aβ25–35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β signaling
Publication date: Available online 11 July 2018Source: Life SciencesAuthor(s): Wenjing Cheng, Weimei Chen, Peng Wang, Jianfeng ChuAbstractAmyloid β (Aβ) peptide can cause neurotoxicity in Alzheimer's disease (AD). The main purpose of the present study is to investigate the protective role of asiatic acid (AA) against Aβ25–35-induced neurotoxicity in neuronally differentiated PC12 cells. Differentiated PC12 cells were pretreated with 5, 10 or 20 μM AA before treatment with 20 μM Aβ25–35. The viability and apoptosis of differentiated PC12 cells were determined by MTT assay and Annexi...
Source: Life Sciences - July 12, 2018 Category: Biology Source Type: research

Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization
This study was designed to investigate the role and the underlying mechanism of GRIM-19 in osteosarcoma progression.Materials and methodsOsteosarcoma tissues and cell lines were utilized to analyze the expressions of GRIM-19 in osteosarcoma by qRT-PCR and Western blot. Methods containing flow cytometry, irradiation exposure, cells inoculation, plasmid transfection, and protein immunoprecipitation were used to investigate the underlying mechanisms of GRIM-19 in osteosarcoma progression.Key findingsGRIM-19 is downregulated in osteosarcoma tissues and cell lines. Exposure to radiation induces osteosarcoma cell apoptosis by up...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo
Publication date: Available online 30 April 2018Source: Life SciencesAuthor(s): Guiquan Yu, Jing Chen, Siyu Li, Peng Pu, Wei Huang, Yongpeng Zhao, Xin Peng, Ruiyu Wang, Han LeiAbstractAimsVascular restenosis and neointimal hyperplasia are enhanced in metabolic syndrome (MetS). Vascular smooth muscle cell (VSMC) proliferation is a key step during restenosis and is suppressed by RING finger protein 10 (RNF10). However, the effect of RNF10 on neointimal hyperplasia is unknown. In the present study, we explored whether RNF10 over-expression prevents neointimal hyperplasia in a MetS rat model and in cultured VSMCs exposed to hi...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

CXCR4 overexpression is correlated with poor prognosis in colorectal cancer
In conclusion, our findings suggest that CXCR4 might contribute to clinical tumour progression and may be a valuable prognostic biomarker in colorectal cancer treatment.Graphical abstract (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells
In this study, we hypothesize that exogenous H2S may protect cardiac cells against high glucose (HG)-induced myocardial injury and inflammation with the involvement of the CIRP-MAPK signaling pathway.Main methodsH9c2 cardiac cells cultured under HG conditions were transfected with siRNA and different inhibitors for detecting the effects of sodium hydrogen sulfide (NaHS) (a H2S donor) on cell biological processes. The cardiac cell viability and LDH activity were determined by CCK-8 and LDH kit. ELISA was employed to measure the levels of inflammatory factors, while 2′,7′-dichlorofluorescein diacetate (DCFH-DA) t...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Wnt signaling in bone metastasis: mechanisms and therapeutic opportunities
Publication date: Available online 30 June 2018Source: Life SciencesAuthor(s): Xin Li, Jing Yang, Minyue Bao, Kan Zeng, Shijin Fu, Chenglin Wang, Ling YeAbstractBone metastasis frequently occurs in advanced cancer patients, who will develop osteogenic/osteolytic bone lesions in the late stage of the disease. Wnt signaling pathway, which is mainly grouped into the β-catenin dependent pathway and β-catenin independent pathway, is a well-organized cascade that has been reported to play important roles in a variety of physiological and pathological conditions, including bone metastasis. Regulation of Wnt signaling in...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis
Publication date: Available online 2 July 2018Source: Life SciencesAuthor(s): Kei Zaitsu, Saki Noda, Akira Iguchi, Yumi Hayashi, Tomomi Ohara, Yuya Kimura, Yuta Koketsu, Tomoko Kosaki, Maiko Kusano, Takako Sato, Tetsuya Ishikawa, Hitoshi Tsuchihashi, Koichi Suzuki, Akira IshiiAbstractAimsSerotonin syndrome (SS) is an adverse outcome of selective serotonin reuptake inhibitors, though its mechanism is not understood and there is no specific clinical biomarker. In this article, metabolic profiles of the SS model rats and causes of metabolome disruption were investigated.Main methodsGas chromatography-tandem mass spectrometry ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Corticotropin-releasing factor suppresses glioma progression by upregulation of long non-coding RNA-p21
In this study, we found CRF mRNA expression was significantly down-regulated in glioma mice. Moreover, CRF could suppress the proliferation of glioma cells and promote the expression of lincRNA-p21. Afterwards, lincRNA-p21 repressed the proliferation and invasion of glioma cells, which was reversed by miR-34c targeted with 3′-UTR. Furthermore, miR-34c decreased the expression of CRFR1 by binding with the 3′-UTR, which interact with CRF to inhibit the proliferation of glioma cells. Together, these results CRF plays as an important role in glioma progression and metastasis through activation of lincRNA-p21, provi...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Platinum-induced muscle wasting in cancer chemotherapy: Mechanisms and potential targets for therapeutic intervention
Publication date: Available online 6 July 2018Source: Life SciencesAuthor(s): Alexandra Moreira-Pais, Rita Ferreira, Rui Gil da CostaAbstractPlatinum-based drugs are among the most effective anticancer therapies, integrating the standard of care for numerous human malignancies. However, platinum-based chemotherapy induces severe side-effects in cancer patients, such as cachexia. Weight loss, as well as fatigue and systemic inflammation are characteristics of this syndrome that adversely affects the survival and the quality of life of cancer patients. The signalling pathways involved in chemotherapy-induced cachexia are sti...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Flexibility in metabolism bestows tenacious viability on cancer
Publication date: Available online 6 July 2018Source: Life SciencesAuthor(s): Yanlu Xiong, Lei Wang, Yangbo Feng, Xiaofei Li, Lintao Jia, Yong HanAbstractCancer cells display altered metabolism distinct from non-transformed cells, which is correlated closely with malignant biocharacteristics. Flexibility remains the central feature of metabolic alteration, enabling cancer cells to survive and thrive in the challenge of inner and outer environments. In this review, we summarise how cancer reprogrammes its metabolism nimbly and adaptively. To begin with, cancer cells adapt metabolism cunningly to supply sufficient materials ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Icariin alleviates murine lupus nephritis via inhibiting NF-κB activation pathway and NLRP3 inflammasome
Publication date: Available online 6 July 2018Source: Life SciencesAuthor(s): Bofeng Su, Hong Ye, Xiaohan You, Haizhen Ni, Xuduan Chen, Linlin LiAbstractAimsLupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatment. Icariin, which is isolated from Chinese medicine Horny Goat Weed (Ying Yang Huo), has been shown to have anti-inflammation activity, and inhibit activations of both NF-κB and NLRP3 inflammasome. In present study, t...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Multiparametric radiomics improve prediction of lymph node metastasis of rectal cancer compared with conventional radiomics
Publication date: Available online 7 July 2018Source: Life SciencesAuthor(s): Li-Da Chen, Jin-Yu Liang, Hui Wu, Zhu Wang, Shu-Rong Li, Wei Li, Xin-Hua Zhang, Jian-Hui Chen, Jin-Ning Ye, Xin Li, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Jian-Bo Xu, Wei WangAbstractAimsTo establish multiparametric radiomics of rectal tumor for the preoperative prediction of lymph node (LN) metastasis.Materials and methodsThis prospective study consisted of 115 consecutive patients with rectal carcinoma between April 2015 and April 2017. The multiparametric radiomics scores were extracted from the endorectal ultrasound (ERUS), computed tomography...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies
Publication date: Available online 7 July 2018Source: Life SciencesAuthor(s): Jéssica H.M. Marques, André L. Mota, Jessica G. Oliveira, Jéssica Z. Lacerda, Júlia P. Stefani, Lívia C. Ferreira, Tialfi B. Castro, Andrés F. Aristizábal-Pachón, Debora A.P.C. ZuccariAbstractAimsBreast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis
Publication date: Available online 7 July 2018Source: Life SciencesAuthor(s): Junjun Liu, Qiuhua Chen, Suzi Liu, Xiaoting Yang, Yan Zhang, Fengjie HuangAbstractAimsAcute respiratory distress syndrome (ARDS), one of the serious form of acute lung injury (ALI), is the primary cause of death in patients with ALI. Sini decoction (SND) is a widely used Traditional Chinese Medicine (TCM). However, the application of SND in ALI is rarely reported.Previous studies have found that renin-angiotensin-aldosterone system (RAAS) played vital and bidirectional roles in ALI. Therefore, the aim of the present study was to investigate prote...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs
Publication date: Available online 7 July 2018Source: Life SciencesAuthor(s): Maria Cristina Aisa, Alessandro Datti, Antonio Orlacchio, Gian Carlo Di RenzoAbstractNonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the treatment of pain and inflammation. Although it is well known that NSAIDs can suppress bone growth, remodelling and repair, they are largely used post-operatively and post-traumatically to achieve analgesia and reduce inflammation in bone tissue.AimsThe impact of two NO-releasing, non-selective NSAIDs, NCX-4016 and HCT-3012 (NO-derivatives of Aspirin and Naproxen, respectively) on osteo...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Hypoxic preconditioning enhances cell hypoxia tolerance and correlated lncRNA and mRNA analysis
This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA.Main methodsHuman osteoblast was used. Normoxic control group (N) were cultured in normoxic culture medium (L-DMEM, 10% FBS and 1% penicillin–streptomycin) 8 h. Long-term hypoxic group (H) were cultured in 4 h hypoxic culture medium (200 μmol/L CoCl2 and L-DMEM)/4 h normoxic culture medium. Hypoxic preconditioning group (HP) were received 3 times HP (cultured in 10 min hypoxic culture medium/10 min normoxic culture medium, which was HP 1times) and then cultured in 4 h hypoxic c...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Peng Li, Xi-Ru Chen, Fei Xu, Chi Liu, Chang Li, Hui Liu, Hui Wang, Wei Sun, Yan-Hui Sheng, Xiang-Qing KongAbstractSepsis-induced myocardial dysfunction represents a major cause of death. Alamandine is an important biologically active peptide. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonatal rat cardiomyocytes. Alamandine increase...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Bisphenol a and mesenchymal stem cells: Recent insights
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Helga Caputo Nunes, Wellerson Rodrigo Scarano, Elenice Deffune, Sérgio Luis Felisbino, Immacolata Porreca, Flávia Karina DelellaAbstractMesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem cells...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Maternal one carbon metabolism through increased oxidative stress and disturbed angiogenesis can influence placental apoptosis in preeclampsia
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Vaishali V. Kasture, Deepali P. Sundrani, Sadhana R. JoshiAbstractAdequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women with preeclampsia. Homocysteine is known to be involved in the formation of free radicals l...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Qian Zhou, Chaoqun You, Cong Zheng, Yawen Gu, Hongchao Gu, Rui Zhang, Hongshuai Wu, Baiwang SunAbstractDNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based der...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Greeshma Tom, Sheena Philip, Rimal Isaac, P.K. Praseetha, S.G. Jiji, V.V. AshaAbstractAimsSuperparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery vehicles, offer to eliminate the concerns associated with hydrophobic anti-cancer agents. The current study was intended to fabricate a SPION based delivery system for sorafenib that can simultaneously enable targeted delivery of sorafenib and expand its therapeutic index against hepatocellular carcinoma (HCC).Main methodsCo-precipitation and physical entrapment methods were employed for the ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Christiano R.R. Alves, Daniele de P. Faria, Camila de G. Carneiro, Alexandre T. Garcez, Vanessa P. Gutierrez, Willian das Neves, Ney R. de Almeida, Yara Cury, Roger Chammas, Patricia C. BrumAbstractNoninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animal...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Xiaolin Peng, Zhengming Wang, Yang Liu, Xin Peng, Yao Liu, Shan Zhu, Zhe Zhang, Yuling Qiu, Meihua Jin, Ran Wang, Qingying Zhang, Dexin KongAbstractAimsMelanoma remains to be one of the most incurable cancers. Discovery of novel antitumor agent for melanoma therapy is expected. We recently isolated Oxyfadichalcone C from Oxytropis falcate and investigated the anti-proliferative and anti-metastatic activity on human melanoma A375 cells in vitro.Main methodsCell viability was determined using MTT assay and soft agar cloning formation assay. The effect...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: Evidence for its anti-neuroinflammatory properties
In this study, DET (0.625. 1.25 and 2.5 mg/kg, i.p.) was administered in rats for 21 days and those animals were challenged with single injection of LPS (250 μg/kg, i.p.) for 7 days. Cognitive and behavioral assessment was carried out for 7 days followed by molecular assessment on brain hippocampus. Statistical significance was analyzed with one-way analysis of variance followed by Dunnett's test to compare the treatment groups with the control group.Key findingsDET ameliorated LPS-induced neuroinflammation by suppressing major pro-inflammatory mediators such as iNOS and COX-2. Furthermore, DET enhanced the an...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Neuralized1a regulates asymmetric division in mouse Lewis lung carcinoma cells
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Liangsheng Kong, Jingyuan Li, Yongli Liu, Zhiwei Sun, Shixia Zhou, Junling Tang, Ting Ye, Jianyu Wang, H. Rosie XingAbstractAsymmetric division (ASD), the unique characteristic of normal stem cells, is regarded as a stemness marker when applied to the study of cancer stem cells (CSCs). However, the role of ASD in the self-renewal of CSCs and its regulation remain largely unknown. Here, we first established a mouse Lewis lung carcinoma CSC cell line that could undergo asymmetric division (LLC-ASD cells) derived from the parental mouse Lewis lung carc...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy via miR-378/TRAF5 signaling pathway
This study aims to explore the effect of AS-IV on diabetic nephropathy progression.Materials and methodsThe diabetic nephropathy model was established in rats with streptozotocin (STZ) injection. The albuminuria was examined by using the enzyme linked immunosorbent assay (ELISA). The expression of miR-378, tumor-necrosis factor (TNF) receptor (TNFR)-associated factor 5 (TRAF5) mRNA and protein was analyzed by qRT-PCR and western blot, respectively. Cell transfection was conducted for modulating endogenous expression of miR-378. Dual luciferase reporter assay was used to evaluate the interaction between miR-378 and TRAF5. T...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes
This study was conducted to analyze the attributive properties of puerarin against mitochondrial dysfunction and inflammation in skeletal muscle cells with insulin resistance.Main methodsThe effects of puerarin on mitochondrial biogenesis, oxidative phosphorylation, dynamics of fusion, fission and mitophagy, oxidative stress, as well as inflammatory response and insulin sensitivity in L6 myotubes treated with palmitate were examined.Key findingsPuerarin pretreatment improve insulin sensitivity and prevented muscle cells from palmitate-induced mitochondrial dysfunction manifested by the increases of complex I activity, mito...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease
In conclusion, RT was effective in reducing fibrosis and inflammation, in addition to increasing muscle strength and creatine kinase levels, in rats with CKD, independent of muscle mass. (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Expression analysis of a cholecystokinin system in human and rat white adipose tissue
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): Adrián Plaza, Beatriz Merino, Andrés Sánchez-Pernaute, Antonio J. Torres-García, Miguel A. Rubio-Herrera, Mariano Ruiz-GayoAbstractAimCholecystokinin (CCK) participates in the storage of dietary triglycerides in white adipose tissue (WAT). Our goal was to characterize, both in subcutaneous (Sc-WAT) and visceral WAT (Vis-WAT), the functional expression of the two known CCK receptors, CCK-1 (CCK-1R) and CCK-2 (CCK-2R), as well as of CCK.Main methodsGene and protein expression was assessed in different cell types of rat and ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP/TRX/NLRP3 pathway in rats
ConclusionsOur results demonstrated that PAH exhibited antidepressant-like effect in CUMS-induced rats model of depression, which might be mediated by TXNIP/TRX/NLRP3 pathway. (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Editorial Board
Publication date: 1 August 2018Source: Life Sciences, Volume 206Author(s): (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Lectins as mitosis stimulating factors: Briefly reviewed
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Elba V.M.M. Carvalho, Weslley F. Oliveira, Luana C.B.B. Coelho, Maria T.S. CorreiaAbstractLectins are carbohydrate binding proteins that can stimulate cell proliferation. This property makes these biomolecules capable of being used as mitogen reagents to study the interaction with lymphocytes allowing evaluation of immunomodulatory action, since B and T lymphocytes are related to humoral and innate immunity, respectively. Isolated cells from spleen, which include lymphocytes, are widely applied as a model in screening lectin mitogenic capacity. Thi...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Emerging role of MicroRNAs in peripheral nerve system
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Jiayi Zhang, Yang Liu, Laijin LuAbstractPeripheral nerve injury is one of the most common clinical diseases. Although the regeneration of the peripheral nerve is better than that of the nerves of the central nervous system, because of its growth rate restrictions after damage. Hence, the outcome of repair after injury is not favorable. Small RNA, a type of non-coding RNA, has recently been gaining attention in neural injury. It is widely distributed in the nervous system in vivo and a significant change in the expression of small RNAs has been obse...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Sonodynamic therapy: A potential treatment for atherosclerosis
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Chi Geng, Yunlong Zhang, Tesfaldet Habtemariam Hidru, Lianyun Zhi, Mengxing Tao, Leixin Zou, Chen Chen, Huihua Li, Ying LiuAbstractAtherosclerosis (AS), a chronic arterial disease, is one of the major causes of morbidity and mortality worldwide. Several treatment modalities have been demonstrated to be effective in treating AS; however, the mortality rate due to AS remains high. Sonodynamic therapy (SDT) is a promising new treatment using low-intensity ultrasound in combination with sonosensitizers. Although SDT was developed from photodynamic ther...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Novel multi-target directed ligand-based strategies for reducing neuroinflammation in Alzheimer's disease
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Tyler Joseph Wenzel, Andis KlegerisAbstractAlzheimer's disease (AD) is one of the most common causes of dementia. AD pathogenesis has been hypothesized to involve cholinergic deficits, amyloid-beta protein (Aβ) deposition, tau protein hyperphosphorylation, and chronic neuroinflammation. Many single-target drugs have gone through the various stages of pre-clinical and clinical development in an effort to cure AD; however, the current clinically approved drugs have only limited effects on the disease progression. With the accumulation of unsucce...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Resveratrol: An overview of its anti-cancer mechanisms
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Mohamed Elshaer, Yeru Chen, Xiu Jun Wang, Xiuwen TangAbstractCancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy are the conventional primary treatments for cancer patients. However, most of cancer cells develop resistance to both chemotherapy and radiotherapy after a period of treatment, besides their lethal side-effects. This motivated investigators to seek more effective alternatives with fewer side-effects. In the last few years, resveratrol, a natural polyphenolic phytoalexin, has attracted much attention due ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Pleiotropic roles of the ubiquitin-proteasome system during viral propagation
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Qi Tang, Peng Wu, Huiqing Chen, Guohui LiAbstractProtein ubiquitination is a highly conserved post-translational modification affecting various biological processes including viral propagation. Ubiquitination has multiple effects on viral propagation, including viral genome uncoating, viral replication, and immune evasion. Ubiquitination of viral proteins is triggered by the ubiquitin-proteasome system (UPS). This involves the covalent attachment of the highly conserved 76 amino acid residue ubiquitin protein to target proteins by the consecutive a...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Do hepatocellular carcinomas located in subcapsular space or in proximity to vessels increase the rate of local tumor progression? A meta-analysis
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Zhi-Cheng Lai, Jin-Yu Liang, Li-Da Chen, Zhu Wang, Si-Min Ruan, Xiao-Yan Xie, Ming-De Lu, Hang-Tong Hu, Wei WangAbstractAimsTo determine if tumors located in the subcapsular space or in proximity to vessels would be a risk factor of local tumor progression (LTP2) in hepatocellular carcinomas (HCC) after radiofrequency ablation.Materials and methodsA search of the MEDLINE, EMBASE and Cochrane Library databases from 1998 to 2017 was performed to identify studies examining the risk factors of LTP after radiofrequency ablation (RFA3) in HCC. No languag...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion
ConclusionsThe administration of a single dose of Dex protects against AKI and CKD. Dex inhibits tubular cell senescence and inflammation as well as improves renal fibrosis to moderate the AKI-to-CKD transition. The renal protective potential of Dex may provide a novel treatment strategy for high-risk renal injury patients. (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Emodin as a selective proliferative inhibitor of vascular smooth muscle cells versus endothelial cells suppress arterial intima formation
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Kang Xu, Mohanad Kh. Al-ani, Chunli Wang, Xuefeng Qiu, Qingjia Chi, Peng Zhu, Nianguo DongAbstractA well-known natural anthraquinone “Emodin”, has been proven to inhibit the proliferation of vascular smooth muscle cells (VSMCs). But the anti-proliferative effects of emodin on both VSMCs versus vascular endothelial cells (VECs) are still largely unknown. Herein, a comparative study for the evaluation of anti-proliferation effects of emodin on human VSMCs and VECs was designed. Various methodologies including MTS, EdU assay, FACS analysis...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Joytirmay Tripathy, Anindita Tripathy, Muthusamy Thangaraju, Mrutyunjay Suar, Selvakumar ElangovanAbstractAimsInvasion and metastasis are the main cause of mortality in breast cancer. Hence, novel therapeutic interventions with high specificity toward invasion and metastasis are necessary. α-Lipoic acid showed antiproliferative and cytotoxic effects on several cancers including breast cancer. However, the effect of lipoic acid on breast cancer metastasis remains unclear.Main methodsIn the present study, we examined the effects of lipoic acid ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Exercise induced improvements in insulin sensitivity are concurrent with reduced NFE2/miR-432-5p and increased FAM3A
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Yong Zhang, Jianyong Wan, Shiqiang Liu, Tianmiao Hua, Qingyan SunAbstractAimsLittle is known regarding whether the NFE2/miR-423-5p and FAM3A-ATP-Akt pathway in liver mediates exercise allured alleviation of insulin resistance connected with diet-induced obesity. This research inquired the influence of exercise on liver insulin sensitivity and whole body insulin resistance in high-fat diet fed rats.Materials and methodsForty male Sprague-Dawley rats at seven-week-old were assigned to four groups at random: standard diet as normal control group (NC, ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Molecular basis of growth hormone daily mRNA and protein synthesis in rats
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): T. de Castro Barbosa, R.B. Salgueiro, C. Serrano-Nascimento, F.G. Amaral, J. Cipolla-Neto, M.T. NunesAbstractAimsDaily and seasonal rhythms coordinate the endocrine and metabolic functions. The pituitary gland is the master regulator of several endocrine activities, and its function is classically regulated by endocrine signals from its target glands as well as from the hypothalamus. The growth hormone (GH) produced and secreted by the anterior pituitary presents a pulsatile secretion throughout the 24-hour cycle. However, the molecular mechanisms ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Physical enrichment enhances memory function by regulating stress hormone and brain acetylcholinesterase activity in rats exposed to restraint stress
This study shows the beneficial effects of environmental enrichment on learning and spatial memory by reducing oxidative stress via reducing lipid peroxidation and regulation of antioxidant enzymes in rats. (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Fares E.M. Ali, Adel G. Bakr, Amira M. Abo-youssef, Amany A. Azouz, Ramadan A.M. HemeidaAbstractAimThe effects of diosmin (DS), pentoxifylline (PTX) and their combination on inflammatory response, oxidant/antioxidant balance, cytoglobin and cirrhotic reaction during bile duct ligation (BDL) were investigated and explored.Main methodsFifty adult male Wistar albino rats were randomly allocated to five groups as following, sham: received vehicle only, BDL: subjected to common BDL without treatment, BDL plus DS: received 100 mg/kg/day orally, BDL plu...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Wall shear stress promotes intimal hyperplasia through the paracrine H2O2-mediated NOX-AKT-SVV axis
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Haolong Zhang, Zhipeng Yang, Jing Wang, Xuehu Wang, Yu Zhao, Fangyu ZhuAbstractAimsOscillatory wall shear stress (WSS)-linked oxidative stress promotes intimal hyperplasia (IH) development, but the underlying mechanisms are not completely understood.Materials and methodsWe used an in vivo rabbit carotid arterial stenosis model representing different levels of WSS and found that WSS was increased at 1 month with 50% stenosis and was accompanied by VSMCs proliferation and interstitial collagen accumulation. Increased WSS promoted the expression of ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Supra-physiological concentration of glyoxylate inhibits proliferation of human colon cancer cells through oxidative stress
This study depicts that supra-physiological concentration of Glx inhibits the proliferation of colon cancer cells due to oxidative stress.Graphical abstract (Source: Life Sciences)
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro
This study aimed to investigate the effects of acetyl-11-keto-β-boswellic acid (AKBA) on activated dendritic cells (DCs) using an imiquimod (IMQ)-induced psoriasis-like mouse model and murine bone marrow–derived dendritic cells (BMDCs) stimulated with resiquimod (R848) in vitro.Materials and methodsThe mice were treated with IMQ and intragastrically administered 25–100 mg/kg/day of AKBA, 1 mg/kg/day of methotrexate (MTX), or normal saline. The inflammation of skin lesions in IMQ mice were evaluated by psoriasis area and severity index (PASI) and pathological staining. The related proteins of Toll-like ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Marziyeh Salehi Jahromi, Jennifer W. Hill, Fahimeh Ramezani Tehrani, Azita Zadeh-VakiliAbstractIntroductionThe methylation level of promoters is one of the most studied and well-known epigenetic mechanisms that programs the amount of gene expression. Over expression of steroidogenesis genes via epigenetic control can result in hypetandrogenism, which is the main endocrine aspect of polycystic ovarian syndrome (PCOS).AimsIn the present study we aimed to determine and compare the promoter methylation levels of three steroidogenic genes, CYP17, GATA6 ...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

The role of miR-328 in high glucose-induced endothelial-to-mesenchymal transition in human umbilical vein endothelial cells
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Yunxiao Chen, Qin Yang, Yuliang Zhan, Junsong Ke, Ping Lv, Jun HuangAbstractAimsEndothelial-to-mesenchymal transition (EndMT) contribute to diabetic cardiac fibrosis, the underlying mechanisms are poorly understood. In the study, we aimed to investigate the role of miR-328 in EndMT mediated by high glucose (HG) and the signaling pathways implicated in human umbilical vein endothelial cells (HUVECs).Materials and methodsEndMT of HUVECs was determined by immunofluorescent staining and western blot of the markers CD31 and α-SMA. Real-time polyme...
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research