A review on the forensic toxicology of global drug-facilitated sexual assaults
CONCLUSIONS: The findings suggest that a diverse range of substances are associated with DFSA and that victims are rendered vulnerable through recreational substance consumption at social events. As such, typical DFSA cases appear to be opportunistic in nature and primarily involves women in their mid-twenties and an acquaintance as the perpetrator.PMID:35048994 | DOI:10.26355/eurrev_202201_27767 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: K Skov S S Johansen K Linnet M K K Nielsen Source Type: research

Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice
CONCLUSIONS: Long-term intranasal administration of dantrolene did not significantly change the nasal mucosa morphology in 5XFAD mice.PMID:35048995 | DOI:10.26355/eurrev_202201_27768 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: B Jiang Y Shi M B Abou L Xu G Liang H Wei Source Type: research

Talbinah (Barley Porridge): neurotransmitters modulatory effect and antidepressant-like action in experimentally depressed rats
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):204-210. doi: 10.26355/eurrev_202201_27769.ABSTRACTOBJECTIVE: Talbinah is a traditional barley porridge used as food and brain tonic by Arabs to alleviate depression and reduce stress. It is a food product with the high potentiality to be used as a functional food. The present study was designed to explore the antidepressant-like effects of Talbinah (Barley porridge).MATERIALS AND METHODS: Thirty-two adult rats were assigned into four groups: negative control group (normal environment), stress-model group, Prozac-treated stress group, and Talbinah treated stress group. The last thr...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: H S Alamri Source Type: research

The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats
CONCLUSIONS: These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia-reperfusion injury.PMID:35048997 | DOI:10.26355/eurrev_202201_27770 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Jafarova Demirkapu S Karabag H M Akgul C Mordeniz H R Yananli Source Type: research

Effects of edaravone combined with Oxiracetam on neuronal apoptosis in rats with cerebral infarction through targeting SIRT1/NF- κB inflammatory pathway
The objective of this study was to investigate the effects of edaravone combined with oxiracetam on neuronal apoptosis in rats with cerebral infarction (CI) and to explore the potential molecular mechanism.MATERIALS AND METHODS: A total of 36 Sprague-Dawley rats were randomly divided into sham-operation group (n=12), model group (n=12) and treatment group (n=12). Only the external carotid artery was exposed in sham-operation group, while the models of CI were established using suture method in the other two groups. After modeling, the rats in sham-operation group and model group were intraperitoneally injected with normal ...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: X-P Cui J-X Ye H Lin H Zhou S Ye J-S Mu Source Type: research

Corpus callosum volumetrics and clinical progression in early multiple sclerosis
CONCLUSIONS: In early MS patients with higher EDSS at baseline, a significant increase in confluent CC lesions size is evident, particularly in the callosal body. Also, median CCR is significantly associated with MS progression in the whole MS group, regardless of initial EDSS. Given their significant association with disability, we encourage measuring CC body lesions and residual CC size for therapeutic decisions and prognostic planning in early MS.PMID:35048999 | DOI:10.26355/eurrev_202201_27772 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M A Sotgiu G Piga V Mazzarello I R Zarbo A Carta L Saderi S Sotgiu M Conti L Saba P Crivelli Source Type: research

A systematic review of the pharmacotherapy of secondary hyperparathyroidism (SHPT) in grades 3-5 Chronic Kidney Disease (CKD)
CONCLUSIONS: Calcifediol ER, paricalcitol, and cinacalcet significantly decreased the iPTH level in the patients under study. Paricalcitol increased the serum calcium concentration the most of all the drugs under analysis. It is noteworthy that only cinacalcet does not carry the risk of hypercalcemia.PMID:35049000 | DOI:10.26355/eurrev_202201_27773 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Miedziaszczyk I Idasiak-Piechocka O W Wi śniewski K Lacka Source Type: research

Role of the variant rs3774261 of adiponectin gene on adiponectin levels and ratio adiponectin/leptin after biliopancreatic diversion in morbid obese subjects
CONCLUSIONS: G allele carriers of rs3774261 showed a delay in the improvement of glucose metabolism parameters, adiponectin and adiponectin/leptin ratio.PMID:35049001 | DOI:10.26355/eurrev_202201_27774 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: D Pacheco O Izaola D Primo D de Luis Source Type: research

Bone mineral density and complete blood count ratios in children and adolescents with obesity
CONCLUSIONS: Our study outcomes show that there may be a relationship between bone mass and inflammation expressed as PLR and MLR in obese children and adolescents. PLR and MLR, which are common indicators of morbidity and mortality in many chronic inflammatory diseases, may also be useful for evaluating bone status in children with obesity. However, further research on the subject is warranted.PMID:35049002 | DOI:10.26355/eurrev_202201_27775 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M M Bala K A Bala Source Type: research

Analysis of surgical treatment strategy and outcome factors in persistent tracheoesophageal fistula: a critical analysis of own cases and review of the literature
CONCLUSIONS: According to the literature, surgical closure of persistent TEFss is demanding. Our data suggest that, considering that the majority of patients with persistent TEFs exhibit multiple risk factors, early performance of more invasive surgery seems associated with a better outcome.PMID:35049003 | DOI:10.26355/eurrev_202201_27776 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Koch A Vasconcelos Craveiro K Mantsopoulos M Sievert A-O Gostian H Iro Source Type: research

Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):270-277. doi: 10.26355/eurrev_202201_27777.ABSTRACTVaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome of these patients is very variable. Here we report the lung ultrastructural findings in the course of VITT of a 58-year-old male patient. Alveoli were mainly dilated, irregular in shape, and occupied by a reticular network of fibrin, while interalveolar septa appeared thickened. The proliferation ...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: T Congiu D Fanni M Piras C Gerosa F Cau D Barcellona E D'Aloja R Demontis A Chighine M Nioi P Coni A Ravarino G Cerrone V Aimola C Botta A Scano G Orr ù F Coghe P Van Eyken G La Nasa L Saba J S Suri G Faa F Marongiu Source Type: research

Acute embolisms in multiple arterial districts following Ad26.COV2-S vaccine
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):278-283. doi: 10.26355/eurrev_202201_27778.ABSTRACTA case of multiple arterial thrombosis/embolisms in a 74-year-old Caucasian man with no other cardiovascular risk factors who received Ad26.COV2-S vaccine 16 days before is reported. The unusual presentation required a longer diagnostic workup. The clinical manifestations and the therapy-specific response suggest an unusual presentation of Vaccine-induced immune thrombotic thrombocytopenia (VITT).PMID:35049005 | DOI:10.26355/eurrev_202201_27778 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: V Murru V Cocco C Marras A Sestu F Marongiu L Saba M E Cianchetti A Scuteri Source Type: research

The COVID-19 pandemic and its consequences for the diagnosis and therapy of head and neck malignancies
CONCLUSIONS: This study shows that there was no significant change in either the number and severity of HNSCC diagnoses or the time until start of therapy at this large head and neck cancer centre as a result of the COVID-19 pandemic.PMID:35049006 | DOI:10.26355/eurrev_202201_27779 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Balk R Rupp A V Craveiro M Allner P Grundtner M Eckstein M Hecht H Iro A-O Gostian Source Type: research

COVID-19 pandemic, substance use disorders and body image issues, a worrisome correlation
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):291-297. doi: 10.26355/eurrev_202201_27780.ABSTRACTThe SARS-CoV-2 pandemic has profoundly affected the social fabric and the economic and health care viability and functioning of most countries. Aside from its deeply destructive impact on health care systems and national economies, the pandemic has jeopardized people's emotional and psychological well-being as well. The authors aimed to shed a light on how the pandemic has been affecting patients with addiction issues and body dysmorphic disorder (BDD), which is characterized by negative thoughts about appearance and body mispercep...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: S Zaami A Sirignano Ó García-Algar E Marinelli Source Type: research

The emerging role of lncRNA MEG3 and MEG3 rs7158663 in hepatocellular carcinoma
This study explored the association between the long non-coding RNA (lncRNA) MEG3 rs7158663 polymorphism, MEG3 expression, and the risk of HCC and other clinicopathologic characteristics in an Egyptian population.PATIENTS AND METHODS: This case-control study included 114 patients with HCC and 110 healthy controls. TaqMan Real-time PCR was used to analyze lncRNA MEG3 rs7158663. Serum MEG3 expression levels were measured using RT-PCR.RESULTS: The AA, GA+AA, and A alleles were associated with increased risk for HCC (adjusted odds ratio (OR) 11.84%, 95% CI 4.07-34.45, p
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: S R Mohammed O G Shaker M M Mohamed M N Abdelhafez Mostafa S N Gaber D Y Ali H A Hussein A M Elebiary A A Abonar H M Eid H S El Sayed Ali Source Type: research

Can evaluating adrenal glands in computed tomography contribute to predicting the prognosis of hospitalized COVID-19 patients?
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):298-304. doi: 10.26355/eurrev_202201_27781.ABSTRACTOBJECTIVE: The novel coronavirus disease 2019 (COVID-19) may affect the adrenal glands. Therefore, it is important to evaluate the morphologic appearance of the adrenal glands by thorax computed tomography (CT). On CT scans, stranding in peripheral fatty tissue with enlarged adrenal glands may indicate signs of adrenal infarction (SAI). The present study aimed to evaluate the incidence of SAI and determine whether this finding may contribute to predictions of the prognosis of COVID-19.PATIENTS AND METHODS: A total of 343 patients w...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Ilgar S Ünlü M Ak çiçek Source Type: research

Assessment of anxiety level and sleep quality of medical staff treating patients with COVID-19
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):312-319. doi: 10.26355/eurrev_202201_27783.ABSTRACTOBJECTIVE: Worldwide transmission of the novel coronavirus (COVID-19) and related morbidity and mortality has presented a global challenge for several reasons. One such underrecognized and unaddressed aspect is the emotional health problems that medical staff have developed during this pandemic. The purpose of this one-month study was to examine anxiety levels and sleep quality of 100 medical staff members who worked in medical clinics treating COVID-19 patients in Saudi hospitals and to investigate the association of both anxiety ...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: A Alboghdadly M J Saadh A M Kharshid M S Shaalan S Z Alshawwa Source Type: research

Social inequalities and nutritional disparities: the link between obesity and COVID-19
CONCLUSIONS: Today, chronic non-communicable degenerative diseases (CDNCDs) are responsible for 70% of public health expenditure, affecting 30% of the population (one or more chronic diseases). Unfortunately, given the health emergency due to SARS-CoV-2, infectious diseases are currently more at the center of attention. However, the spread of infectious communicable diseases and CDNCDs is facilitated in situations of social disparity. In fact, in the poorest countries there are the highest rates of malnutrition and there is a greater risk of contracting viral infections, as well as, paradoxically, a risk of comorbidity, du...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: A De Lorenzo G Cenname M Marchetti P Gualtieri M Dri E Carrano F Pivari E Esposito O Picchioni A Moia L Di Renzo Source Type: research

COVID-19 detection and spread control: what initiatives in Italy for the homeless population?
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):340-344. doi: 10.26355/eurrev_202201_27785.ABSTRACTIn Italy COVID-19 pandemic had a severe impact. The homeless live in situations aggravating their poor health conditions and comorbidities. Although homeless people are a fragile category, no dedicated measures by public health departments seem to be applied infrequently to this population. For these reasons, they are probably one of the categories most affected by the global spread of the SARS-CoV-2. Moreover, the current vaccination campaign against COVID-19 can represent an important opportunity for health and social integration...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: E Di Simone A De Leo N Panattoni F Bonf à M Tatangelo V Tallarita A R Buonomini A Cristaudo D Bracco F Petrone A Morrone Source Type: research

Will weather stem the spread of the COVID-19 in Pakistan?
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):305-311. doi: 10.26355/eurrev_202201_27782.ABSTRACTThe pandemic of COVID-19 started spreading more exponentially across Pakistan since the end of February 2020. Numerous models and factors have been used to estimate predictions of the prevalence and severity of COVID-19 infections around the globe. While many factors play a role in the spread of COVID-19, climate and weather conditions are considered key elements in the transmission of COVID-19. Many researchers believe that recent increases in COVID-19 cases correlate strongly with local temperatures and factors (such as humidity,...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Uzair I Kaleem M Arshad R S Ali A Zafar M Iqbal S Bashir Source Type: research

Clinical insights into cisplatin-induced arrhythmia in a patient with locally advanced non-small cell lung cancer: a case report
CONCLUSIONS: In the present case report, we discuss the potential factors that may provide pivotal contributions to the patient's susceptibility to cardiotoxicity and review the published studies regarding the cardiotoxic influence of cisplatin. We also outline the critical points that oncologists should be aware of when dealing with such high-risk patients.PMID:35049014 | DOI:10.26355/eurrev_202201_27741 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: Y Huang F-Z Guo S Dai H-Y Hu S-Y Fu J-W Liu F Luo Source Type: research

Role of local treatment in primary breast B-cell non-Hodgkin's lymphoma: a propensity score matching-based analysis from SEER database
CONCLUSIONS: In local treatment, surgery offered no survival benefit for patients with primary breast B-cell non-Hodgkin's lymphoma, while RT is an effective choice because it can improve both OS and DSS in the stage IE DLBCL subgroup.PMID:35049015 | DOI:10.26355/eurrev_202201_27743 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Zhang N Liu B-Y Wang J Zhang A Zhao J Yang J Yang Source Type: research

Discoid lupus in antiphospholipid syndrome: case description and literature review
CONCLUSIONS: This study reviewed previous articles on DLE cases associated with antiphospholipid antibodies and/or APS, adding a new case description.PMID:35049016 | DOI:10.26355/eurrev_202201_27744 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: J Freire de Carvalho T Larocca Skare C Figueiredo P R Criado Source Type: research

Prostacyclins and pulmonary arterial hypertension in children
CONCLUSIONS: Epoprostenol can be effective against severe pulmonary hypertension. Iloprost can treat severe persistent pulmonary hypertension in newborns and inhaled iloprost can be used in pulmonary vasoreactivity testing. Treprostinil is a long-acting prostacyclin analog, and it shows the highest antiproliferative activity among prostacyclins. Beraprost may be effective in premature infants, but available evidence comes from only one patient, so more clinical testing is needed.PMID:35049017 | DOI:10.26355/eurrev_202201_27745 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: Y Wu H-M Liu L Gu Q-W Li L Zhu Source Type: research

Clinical effectiveness of a new oral curcumin formulation in acute non-infectious uveitic macular edema: a 12-month observational study
CONCLUSIONS: CHC as an adjuvant treatment improved the anatomical and functional outcomes, without significant side effects in eyes affected by the recent onset of NIUME, compared to the sole standard therapy.PMID:35049018 | DOI:10.26355/eurrev_202201_27746 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: P Allegri R Rosa A Masala R Rissotto F Rissotto M G Crivelli S Peri Source Type: research

Real-life experience of edoxaban treatment for venous thromboembolism (VTE)/pulmonary embolism (PE) in patients with isolated positive Lupus Anticoagulant (LAC) during the COVID-19 pandemic lockdown in Italy
CONCLUSIONS: Edoxaban treatment may be safe and effective in preventing the recurrence of VTE/PE in patients with isolated LAC positivity, without the occurrence of arterial events.PMID:35049019 | DOI:10.26355/eurrev_202201_27747 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: L Puccetti V Sammartano P Calzoni F Bacchiarri A Santoni D Fineschi M Bocchia Source Type: research

Primary epiploic appendagitis: evaluation of computed tomography findings in the differential diagnosis of patients that presented with acute abdominal pain
CONCLUSIONS: When patients with localized lower abdominal pain and tenderness do not have associated symptoms or laboratory abnormalities, a high index of suspicion for PEA and early radiologic examinations are required.PMID:35049020 | DOI:10.26355/eurrev_202201_27748 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: A N Do ğan B Çakıroğlu A H Ak ça S H Aksoy T Akar Source Type: research

High intraoperative blood product requirements in liver transplantation: risk factors and impact on the outcome
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):64-75. doi: 10.26355/eurrev_202201_27749.ABSTRACTOBJECTIVE: Liver transplantation (LT) is associated with a significant bleeding and the high transfusion requirements (HTR) negatively affect the outcome of LT patients. Our primary aim was to identify potential predictors of intraoperative transfusion requirements. Secondarily, we investigated, the effect of transfusion requirements on different clinical outcomes, including short-term morbidity and mortality.PATIENTS AND METHODS: Data collected in 219 adult LT from a deceased donor, grouped according to HTR (defined as the need of 5...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: L Teofili C G Valentini P Aceto M Bartolo L Sollazzi S Agnes R Gaspari A W Avolio Source Type: research

Predictive value of inflammatory and hematological data in diabetic and non-diabetic retinopathy
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):76-83. doi: 10.26355/eurrev_202201_27750.ABSTRACTOBJECTIVE: The current study aimed at investigating the predictive role of inflammatory, hematological and biochemical parameters in diabetic and non-diabetic retinopathy.MATERIALS AND METHODS: The cross-sectional study was conducted between June 2019 and September 2020. We included patients with diabetic retinopathy (proliferative DR=14, non-proliferative DR=16), patients with non-diabetic retinopathy (n=30), patients with Type 2 Diabetes Mellitus (T2DM) without retinopathy (n=30) and control group (n=30). Demographic, hematological...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: H Atl ı E Onalan B Yakar D Duzenci E D önder Source Type: research

Validation of a Korean version of the quality-of-life profile for spine deformities (QLPSD) in patients with adolescent idiopathic scoliosis
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):84-89. doi: 10.26355/eurrev_202201_27751.ABSTRACTOBJECTIVE: We aimed to evaluate the reliability and validity of the adapted Korean version of the Quality-of-Life Profile for Spine Deformities (QLPSD) questionnaire.PATIENTS AND METHODS: English version of QLPSD was translated into Korean according to previously published guidelines. The Korean version of the QLPSD questionnaire and the Korean version of the SRS-22 was sent to 120 consecutive idiopathic scoliosis patients wearing braces recruited from the outpatient clinic. Reliability assessment and construct validity were evaluate...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: S H Park T S Goh Y G Park D S Kim J S Lee Source Type: research

A systematic review and meta-analysis on the efficacy of probiotics for bacterial vaginosis
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):90-98. doi: 10.26355/eurrev_202201_27752.ABSTRACTOBJECTIVE: The current study aimed at assessing the overall efficacy of probiotics for the treatment of bacterial vaginosis (BV) through the review of relevant studies.MATERIALS AND METHODS: A systematic literature review was conducted based largely on the following electronic databases updated to May 2021: Embase, the Cochrane Library, and PubMed, with the use of keywords. The investigators also thoroughly reviewed key pertinent sources in the literature for further inclusion.RESULTS: Eighteen studies including 1651 patients were se...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: H-F Liu N Yi Source Type: research

Impact of maternal age on perinatal outcomes in twin pregnancies: a systematic review and meta-analysis
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):99-109. doi: 10.26355/eurrev_202201_27753.ABSTRACTOBJECTIVE: Current evidence of the maternal, perinatal and neonatal outcomes in twin pregnancies among mothers with advanced age is unclear, especially for mothers with age above 40 years.MATERIALS AND METHODS: A systematic search was conducted using the PubMed, Scopus, and Google Scholar databases. Studies that were observational in design or analysed retrospective data were considered for inclusion. The included studies had to be conducted in twin pregnancies and should have documented the effect of maternal age on obstetric and/o...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: Q-F Xiong Z-H Yu A-L Zhang X-H Zhu Source Type: research

Role of telocytes in the pathogenesis of ectopic pregnancy
This study included patients with ectopic pregnancy (EP) (n=10) and control patients (n=10) (partial salpingectomy for contraception). Immunohistochemical staining for c-Kit, vimentin, CD34 and S100A was performed to quantify telocytes in the mucosa, muscular layer and serosa of fallopian tubes of control and EP group. Spontaneous and KCl- (80 mM) induced contraction and cumulative progesterone dose-relaxation (10-11-10-5 M) and cumulative oxytocin dose-contraction (10-10-10-4 M) responses were recorded.RESULTS: The groups were comparable in terms of age, gravida, parity, delivery type and gestational week (p>0.05). The...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: Y Karasu D Önal S Z ırh N Yersal H Korkmaz Y Üstün S M üftüoğlu B Pehlivano ğlu Source Type: research

Extra-axial hematomas due to road traffic accidents and their outcome: a ten-year study
CONCLUSIONS: Extra-axial hematomas are very common in RTA-related TBIs and have high mortality. SDH is the most common, tSAH had the highest mortality, while EDH has the best survival. Aggressive efforts are compulsory to reduce RTA-related TBI.PMID:35049027 | DOI:10.26355/eurrev_202201_27757 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M A Algahtany Source Type: research

Lidocaine 700 mg medicated plaster for post-herpetic neuralgia: focus on Quality of Life, effectiveness and safety - a retrospective observational study
This study is a retrospective observational investigation of patients with PHN treated with LMP. Patients were regularly followed for pain intensity, co-analgesic consumption, adverse effects, QoL using the EQ-5D, and patient satisfaction for 8 weeks.RESULTS: A total of 31 patients were evaluated. At enrollment, 18 patients (58.1%) were treated with at least one PHN concomitant medication, for which the number and dosing remained constant during the study. Patients had a mean average pain intensity of 6.5±1.0 at baseline, which decreased to 3.6±1.1 at week 4 and 2.8±0.9 at week 8. Four patients reporte...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: L G Giaccari C Aurilio F Coppolino M C Pace M B Passavanti V Pota P Sansone Source Type: research

The effectiveness of mindful parenting training on attention deficit/hyperactivity disorder symptoms in male students
This study aimed at investigating the effect of mindful parenting training on mothers of children with ADHD in reducing the symptoms of hyperactivity/impulsivity and inattention behaviors.MATERIALS AND METHODS: The research method was quasi-experimental with a pretest-posttest control group. The study population consisted of all mothers of children from 8 to 12 years. Therefore, 24 mothers of children with ADHD whose scores in the Connors questionnaire (parent form) were above the cut-off point score and diagnostic interview were selected and randomly paired and assigned into two experimental and control groups. All the mo...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Amiri S A M Fatemi S Jabbari A Nesayan P Farmani Source Type: research

Burnout in the intensive care units in Western Greece
CONCLUSIONS: Effective relationships to establish constructive communication, require the development of skills aiming at building mutual understanding. Possible proposals for future directions in this area of research are discussed. Aiming at improving clinical practice it would be helpful the design of staff support services for better management of exhaustion.PMID:35049030 | DOI:10.26355/eurrev_202201_27760 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Lagadinou A Noti M Adamopoulou M Marangos D Gkentzi Source Type: research

The synergistic effect of palmitic acid and glucose on inducing endoplasmic reticulum stress-associated apoptosis in rat Schwann cells
CONCLUSIONS: The present research indicated that hyperglycemia and hyperlipidemia might exert a synergistic damage during the pathogenesis of DPN, suggesting that blood lipid control is as important as blood glucose control for DPN patients.PMID:35049031 | DOI:10.26355/eurrev_202201_27761 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: D Yang J Xie X-C Liang Y-Z Cui Q-L Wu Source Type: research

Frequently applied ketamine, medetomidine and thiopental anaesthesia induces high mortality in Wistar rats
CONCLUSIONS: Obstruction of the respiratory airways by saliva with subsequent suffocation may have been one of the causes of death, as it appeared in all the affected animals. Although the combination of ketamine and an alpha-2 adrenergic agonist is generally considered to be safe in rats, we propose that studies utilizing protocols requiring repeated anaesthesia adhere to a minimum safety period of 8.5 days between anaesthesia events. Alternative anaesthetic protocols should be employed if adherence to this is not possible due to the nature of the study.PMID:35049032 | DOI:10.26355/eurrev_202201_27765 (Source: European Re...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: J Sajovic M Trandafilovi ć G Dreven šek J Ku žner M Dreven šek Source Type: research

Organophosphates modulate tissue transglutaminase activity in differentiated C6 neural cells
CONCLUSIONS: TG2 inhibitors can protect against organophosphate-induced neuropathy and could be used for developing novel therapeutic strategies for treating brain cancer and neurodegenerative disorders.PMID:35049033 | DOI:10.26355/eurrev_202201_27766 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M A Aldubayan I S Almami S G Felemban A H Alhowail P L R Bonner A J Hargreaves Source Type: research

Parosmia after COVID-19: olfactory training, neuroinflammation and distortions of smell
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):1-3. doi: 10.26355/eurrev_202201_27739.NO ABSTRACTPMID:35049034 | DOI:10.26355/eurrev_202201_27739 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: A Di Stadio L D'Ascanio I La Mantia M Ralli M J Brenner Source Type: research

Good nutrition is essential for vaccine efficacy in elderly subjects
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):4-5. doi: 10.26355/eurrev_202201_27740.NO ABSTRACTPMID:35049035 | DOI:10.26355/eurrev_202201_27740 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: L Curtis Source Type: research

A review on the forensic toxicology of global drug-facilitated sexual assaults
CONCLUSIONS: The findings suggest that a diverse range of substances are associated with DFSA and that victims are rendered vulnerable through recreational substance consumption at social events. As such, typical DFSA cases appear to be opportunistic in nature and primarily involves women in their mid-twenties and an acquaintance as the perpetrator.PMID:35048994 | DOI:10.26355/eurrev_202201_27767 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: K Skov S S Johansen K Linnet M K K Nielsen Source Type: research

Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice
CONCLUSIONS: Long-term intranasal administration of dantrolene did not significantly change the nasal mucosa morphology in 5XFAD mice.PMID:35048995 | DOI:10.26355/eurrev_202201_27768 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: B Jiang Y Shi M B Abou L Xu G Liang H Wei Source Type: research

Talbinah (Barley Porridge): neurotransmitters modulatory effect and antidepressant-like action in experimentally depressed rats
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):204-210. doi: 10.26355/eurrev_202201_27769.ABSTRACTOBJECTIVE: Talbinah is a traditional barley porridge used as food and brain tonic by Arabs to alleviate depression and reduce stress. It is a food product with the high potentiality to be used as a functional food. The present study was designed to explore the antidepressant-like effects of Talbinah (Barley porridge).MATERIALS AND METHODS: Thirty-two adult rats were assigned into four groups: negative control group (normal environment), stress-model group, Prozac-treated stress group, and Talbinah treated stress group. The last thr...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: H S Alamri Source Type: research

The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats
CONCLUSIONS: These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia-reperfusion injury.PMID:35048997 | DOI:10.26355/eurrev_202201_27770 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Jafarova Demirkapu S Karabag H M Akgul C Mordeniz H R Yananli Source Type: research

Effects of edaravone combined with Oxiracetam on neuronal apoptosis in rats with cerebral infarction through targeting SIRT1/NF- κB inflammatory pathway
The objective of this study was to investigate the effects of edaravone combined with oxiracetam on neuronal apoptosis in rats with cerebral infarction (CI) and to explore the potential molecular mechanism.MATERIALS AND METHODS: A total of 36 Sprague-Dawley rats were randomly divided into sham-operation group (n=12), model group (n=12) and treatment group (n=12). Only the external carotid artery was exposed in sham-operation group, while the models of CI were established using suture method in the other two groups. After modeling, the rats in sham-operation group and model group were intraperitoneally injected with normal ...
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: X-P Cui J-X Ye H Lin H Zhou S Ye J-S Mu Source Type: research

Corpus callosum volumetrics and clinical progression in early multiple sclerosis
CONCLUSIONS: In early MS patients with higher EDSS at baseline, a significant increase in confluent CC lesions size is evident, particularly in the callosal body. Also, median CCR is significantly associated with MS progression in the whole MS group, regardless of initial EDSS. Given their significant association with disability, we encourage measuring CC body lesions and residual CC size for therapeutic decisions and prognostic planning in early MS.PMID:35048999 | DOI:10.26355/eurrev_202201_27772 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M A Sotgiu G Piga V Mazzarello I R Zarbo A Carta L Saderi S Sotgiu M Conti L Saba P Crivelli Source Type: research

A systematic review of the pharmacotherapy of secondary hyperparathyroidism (SHPT) in grades 3-5 Chronic Kidney Disease (CKD)
CONCLUSIONS: Calcifediol ER, paricalcitol, and cinacalcet significantly decreased the iPTH level in the patients under study. Paricalcitol increased the serum calcium concentration the most of all the drugs under analysis. It is noteworthy that only cinacalcet does not carry the risk of hypercalcemia.PMID:35049000 | DOI:10.26355/eurrev_202201_27773 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: M Miedziaszczyk I Idasiak-Piechocka O W Wi śniewski K Lacka Source Type: research

Role of the variant rs3774261 of adiponectin gene on adiponectin levels and ratio adiponectin/leptin after biliopancreatic diversion in morbid obese subjects
CONCLUSIONS: G allele carriers of rs3774261 showed a delay in the improvement of glucose metabolism parameters, adiponectin and adiponectin/leptin ratio.PMID:35049001 | DOI:10.26355/eurrev_202201_27774 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 20, 2022 Category: Drugs & Pharmacology Authors: D Pacheco O Izaola D Primo D de Luis Source Type: research