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Evaluation of genotyping methods and costs for IL1 α polymorphisms in Platelet Rich-Plasma (PRP); viewpoint for therapy on the diabetic foot ulcers.
Evaluation of genotyping methods and costs for IL1α polymorphisms in Platelet Rich-Plasma (PRP); viewpoint for therapy on the diabetic foot ulcers. Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):575-577 Authors: Marotta G, Licito A, Serra E, Benincasa G, Crisci A PMID: 29461582 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Mediation of inflammation, obesity and fatty liver disease by advanced glycation endoproducts.
Authors: Milione S, Di Caterino M, Monaco L, Rinaldi L PMID: 29461583 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Correlation of CT indicators of NSCLC and pathological features and the expression level of p53 and c-myc. Positive example of the right way for translational diagnostics.
Authors: Abbadessa A, Muto T, Benincasa G PMID: 29461584 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-125b promotes the regeneration and repair of spinal cord injury through regulation of JAK/STAT pathway.
CONCLUSIONS: Our data revealed that micro-125b was down-regulated in injured spinal cord, and overexpression of micro-125b promoted the repair and regeneration following spinal cord injury through the regulation of the JAK/STAT pathway. PMID: 29461585 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values for detection of malignant vertebral bone marrow lesions.
Authors: Filograna L, Magarelli N, Cellini F, Manfrida S, Leone A, Colosimo C, Valentini V Abstract Malignant spinal bone marrow disorders are one of the major causes of significant morbidity and reduction in quality of life in oncological patients. Thus, the characterization of these conditions is of crucial importance in the management of these patients. Magnetic resonance (MR) imaging plays a vital role in differentiation between benign and malignant spinal bone marrow disorders. However, morphological imaging features, based on T1 and T2 relaxation properties, might fail in differentiating between these conditi...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Primary neoplasms of the small bowel at CT: a pictorial essay for the clinician.
CONCLUSIONS: Multidetector-CT, performed after distension of the small bowel with oral contrast material and intravenous injection of iodinated contrast material, is a useful method for the diagnosis and staging of small bowel neoplasms. PMID: 29461587 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

SPOP suppresses osteosarcoma invasion via PI3K/AKT/NF- κB signaling pathway.
CONCLUSIONS: Our results suggested that down-regulation of SPOP promoted OS cells migratory and invasive ability via modulating the "PI3K/Akt/NF-κB" signaling pathway. Thus, SPOP could be a promising drug target for the treatment of OS invasion. PMID: 29461588 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Long non-coding RNA SNHG16 promotes cell growth and metastasis in ovarian cancer.
CONCLUSIONS: SNHG16 was highly expressed in ovarian cancer, and was correlated with staging, distant metastasis and poor prognosis of ovarian cancer. SNHG16 may activate phosphorylation of AKT and upregulate the expression of MMP9 to promote cell proliferation, invasion and migration of ovarian cancer. PMID: 29461589 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Expression and clinical correlation of NGAL and VEGF in endometrial carcinoma.
Authors: Xu H, Sun X, Sun WJ Abstract OBJECTIVE: To determine the expression of neutrophil gelatinase-associated lipocalin (NGAL) and vascular endothelial growth factor (VEGF) in endometrial carcinoma. PATIENTS AND METHODS: The clinical features (FIGO staging, pathological type, differentiation level, myometrial invasion depth and tumor size) and immunostaining analysis of endometrial carcinoma (30 cases), atypical hyperplasia (30 cases) and proliferative endometrial tissues (30 cases) were analyzed. Immunohistochemistry and reverse transcription PCR (RT-PCR) were performed to detect the expression of NGAL and ...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Reduced SPOCK1 expression inhibits non-small cell lung cancer cell proliferation and migration through Wnt/ β-catenin signaling.
CONCLUSIONS: The expression of SPOCK1 served as a tumor promoter, possibly through the Wnt/β-catenin signaling pathway in NSCLC. Targeting SPOCK1 could be a potential therapeutic strategy in NSCLC. PMID: 29461591 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Health-related quality of life and psychosocial implications in testicular cancer survivors. A literature review.
CONCLUSIONS: It is necessary to identify TCSs with higher risks of poorer QoL outcomes, to focus interventions on the areas with the greatest impairments. Further researches should consider the effects of testicular cancer on the impaired areas, collecting more data to better identify survivor's needs and consequent interventions, with a special focus on adolescent and young adult TCSs. Other works are requested on therapies, preventive and ameliorative, to reduce chronic side effects of testicular cancer treatment. PMID: 29461592 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Expression of miR-205 in renal cell carcinoma and its association with clinicopathological features and prognosis.
Authors: Xu XW, Li S, Yin F, Qin LL Abstract OBJECTIVE: The aim of the present study was to examine the expression of miR-205 in renal cell carcinoma (RCC) tissue and carcinoma cells; also, we aimed to determine the association of miR-205 expression with the clinicopathological features and prognosis of RCC, and to explore the mechanism of miR-205. PATIENTS AND METHODS: Carcinoma tissue and adjacent normal tissue were collected from 60 patients with RCC, and the expression of miR-205 was determined by semi-quantitative PCR, followed by correlation analysis of miR-205 with clinicopathological features and progno...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The impact of NudCD1 on renal carcinoma cell proliferation, migration, and invasion.
This study intends to explore the expression of NudCD1 in renal cancer tissue and its effect on renal cell behavior. PATIENTS AND METHODS: NudCD1 expression in RCC tissue was tested Western blot. The cellular localization of NudCD1 was detected by immunohistochemistry (IHC). NudCD1 highly expressed RCC cell line was selected. NudCD1 knockdown or overexpression was performed through cell transfection. Cell proliferation, migration, and invasion were assessed by MTT assay, wound scratch assay, and transwell assay, respectively. RESULTS: NudCD1 mainly located in the cytoplasm and significantly upregulated in RCC tissu...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-1271 negatively regulates AKT/MTOR signaling and promotes apoptosis via targeting PDK1 in pancreatic cancer.
CONCLUSIONS: MiR-1271 is a potent tumor suppressor in PC, its pro-apoptotic function was partially mediated by reduced AKT/MTOR signaling. Targeting miR-1271 may represent an effective strategy for PC treatment. PMID: 29461595 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Association of the upregulation of LncRNA00673 with poor prognosis for colorectal cancer.
CONCLUSIONS: The expression level of lncRNA00673 is up-regulated in CRC tissues and cells, which is related to the degree of malignancy and poor prognosis. LncRNA00673 can be used as a potential molecular marker for the prognosis of CRC. PMID: 29461596 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The effect and mechanism of metallothionein MT1M on hepatocellular carcinoma cell.
Authors: Zhang S, Huang Z, Zhou S, Wang B, Ding Y, Chu JZ, Wang XL Abstract OBJECTIVE: Liver cancer is one of the most common digestive system malignant solid tumors. Its incidence and mortality rates keep high, causing serious mental and economic burden. So far, the exact mechanism of liver cancer onset has not been fully elucidated. Metallothionein (MT) widely exists in various types of organisms with highly conserved structure. It contains the short peptide of cysteine and sulfur protein with high affinity to heavy metals, including cadmium, zinc, and copper. MT1M is an important member of MT family that has bee...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Association on polymorphisms in LncRNA HOTAIR and susceptibility to HNSCC in Chinese population.
CONCLUSIONS: HOTAIR rs4759314 may influence HNSCC susceptibility and serve as a diagnostic biomarker. PMID: 29461598 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Microvesicles containing microRNA-21 secreted by proximal tubular epithelial cells are involved in renal interstitial fibrosis by activating AKT pathway.
CONCLUSIONS: MicroRNA-21 secreted by injured proximal tubule epithelial cells participated in renal interstitial fibrosis by activating the PTEN/AKT signaling pathway. PMID: 29461599 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Evaluation of the application of high volume hemofiltration in sepsis combined with acute kidney injury.
Authors: Meng SQ, Yang WB, Liu JG, Yuan JY, Zhang K, Ding WY, Yang SQ, Liu JH Abstract OBJECTIVE: To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. PATIENTS AND METHODS: A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respectively. The control group received conventional volume hemofiltration (the ultrafiltration rate of 35-50 ml/kg/h), and the observation group received HVHF (50-100 ml/kg/h). RESULTS: The serum Interleukin-6 (IL-...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease.
Authors: Li JX, Yu GQ, Zhuang YZ Abstract OBJECTIVE: To investigate the impact of serum FGF23 levels on blood pressure of patients with chronic kidney disease (CKD). PATIENTS AND METHODS: 128 patients with chronic kidney disease were selected from February 2013 to January 2016. Using CKD staging method, all the patients were divided into 1 to 5 stages according to the glomerular filtration rate. Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect serum FGF23 levels of CKD patients and healthy control subjects. 24 h blood pressure monitoring method was used to monitor the mean arterial pressure of patie...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Expression of miR-146a-5p in patients with intracranial aneurysms and its association with prognosis.
CONCLUSIONS: MiR-146a-5p expression may serve as a biomarker for predicting prognosis in patients with IAs. PMID: 29461602 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Correlations of 25(OH)D level with blood lipid, inflammatory factors and vascular endothelial function in diabetic patients.
Authors: Wang JM, Ye SD, Li SM, Hu W Abstract OBJECTIVE: To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients. PATIENTS AND METHODS: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. The levels of 25(OH)D in diabetic patients were also compared to detect the levels of serum lipids and inflammatory cyto...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A novel ultrasound-based vascular calcification score (CALCS) to detect subclinical atherosclerosis.
Authors: Flore R, Zocco MA, Ainora ME, Fonnesu C, Nesci A, Gasbarrini A, Ponziani FR Abstract OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)]. PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were eva...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-210 protects cardiomyocytes from OGD/R injury by inhibiting E2F3.
CONCLUSIONS: We confirmed that miR-210 can inhibit the OGD/R-induced apoptosis of cardiomyocytes, and miR-210, as an upstream factor, plays a protective role in cardiomyocytes through directly inhibiting the protein expression of its target gene E2F3. PMID: 29461605 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Daylight saving time and myocardial infarction: should we be worried? A review of the evidence.
Authors: Manfredini R, Fabbian F, De Giorgi A, Zucchi B, Cappadona R, Signani F, Katsiki N, Mikhailidis DP Abstract Transitions into and out of Daylight Saving Time (DST) may disrupt circadian rhythms and lead to sleep disturbance and deprivation. A first report observed an association between DST and acute myocardial infarction (AMI), especially after the spring shift and in women. We tried to identify and evaluate the possible association between DST and AMI, using the MEDLINE, EMBASE and Google Scholar electronic database (years 2009-2016), with regards to the searching terms 'daylight saving time', 'daylight sa...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Assessment of atrial fibrillation and ventricular arrhythmia risk in patients with asthma by P wave/corrected QT interval dispersion.
CONCLUSIONS: PWD value was elevated in asthmatic compared to the control group. The CQTD was not statistically significant between the groups. These results indicate that the risk of developing AF in asthmatic patients might be higher than in the normal population. Ventricular arrhythmia and sudden cardiac death risk may not be high in asthmatic patients. PMID: 29461607 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

High expression of lnc-CRNDE presents as a biomarker for acute myeloid leukemia and promotes the malignant progression in acute myeloid leukemia cell line U937.
Authors: Wang Y, Zhou Q, Ma JJ Abstract OBJECTIVE: To detect the expression of long non-coding RNA-CRNDE in patients with acute myeloid leukemia and its effect on proliferation and apoptosis in acute myeloid leukemia cell line U937. PATIENTS AND METHODS: 81 cases of newly diagnosed acute myeloid leukemia (AML) were enrolled, and 35 non-malignant hematological patients were selected as controls. Quantitative RT-PCR (qRT-PCR) was performed to detect the expression of lncRNA-CRNDE in the bone marrow specimens of the subjects, and the difference between the two groups was also compared. The correlation between the ...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The effects of recombinant human growth hormone (rHGH) on survival of slender narrow pedicle flap and expressions of vascular endothelial growth factor (VEGF) and classification determinant 34 (CD34).
Authors: Sun W, Yu WY, Yu DJ, Zhao TL, Wu LJ, Han WY Abstract OBJECTIVE: To explore the effects of recombinant human growth hormone (rHGH) on the survival of the mouse slender narrow pedicle flap and the expressions of vascular endothelial growth factor (VEGF) and classification determinant 34 (CD34). MATERIALS AND METHODS: A total of 20 BALB/c mice were randomly divided into the experimental group (n=10) and control group (n=10). The flaps were transplanted for mice in two groups respectively. 6 h after the operation, the mice in the experimental group were administrated with rHGH via local subcutaneous inject...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The effect of DC+CIK combined therapy on rat liver cancer model and its modulatory effect on immune functions.
This study aimed to investigate the function of DC+CIK combined treatment on rat liver model and its effect on immune functions. MATERIALS AND METHODS: RH-35 tumor cell was used to prepare live cancer model on Wistar rats, which were further divided into control, CIK and DC+CIK groups, in which rats received autograft CIK and DCs. Tumor size was later measured along with liver function index. The secretions of IFN-γ, IL-4, and TNF-α were measured by Real-time PCR and Western blotting. RESULTS: Both CIK and DC+CIK treatment significantly reduced tumor size and improved liver function, increased secretion...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Leptin inhibits apoptosis of nucleus pulposus cells via promoting autophagy.
Authors: Zhang W, Li ZL, Zhang Q Abstract OBJECTIVE: To investigate whether leptin can regulate the apoptosis of nucleus pulposus cells by adjusting the autophagy of human degenerative nucleus pulposus cells and its possible molecular mechanism. PATIENTS AND METHODS: The human degenerative nucleus pulposus cells were extracted and cultured, then treated with leptin, leptin inhibitor and leptin neutralizing antibody; the expressions of light chain 3 (LC3) II/I and Beclin-1 were detected by Western blot, and the change of apoptosis rate was detected by flow cytometer. After the nucleus pulposus cells were treated...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The hyperthermic intraoperative intraperitoneal chemotherapy in the treatment of advanced abdominopelvic cancer. Personal experience on 103 procedures during a seventeen year period in a single Italian center.
CONCLUSIONS: The surgical resection alone for patients affected by advanced cancer with peritoneal carcinomatosis cannot be considered a sufficient treatment any longer and HIPEC would help to prolong survival in these patients. PMID: 29461612 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Paraquat promotes the epithelial-mesenchymal transition in alveolar epithelial cells through regulating the Wnt/ β-catenin signal pathway.
CONCLUSIONS: PQ promotes RLE-6TN epithelial-mesenchymal transition by upregulating the expression of Wnt/β-catenin. PMID: 29461613 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Mitochondria-mediated disturbance of fatty acid metabolism in proximal tubule epithelial cells leads to renal interstitial fibrosis.
CONCLUSIONS: Mitochondrial dysfunction induced fatty acid metabolism is an important factor to promote the progress of renal interstitial fibrosis. Intervention of related targets of fatty acid metabolism is expected to become a new treatment for renal interstitial fibrosis. PMID: 29461614 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients.
CONCLUSIONS: This study is the first done in patients with allergic rhinitis and/or chronic urticaria using a F1-high speed simulator-driving test evaluating subjects' performance under bilastine treatment. PMID: 29461615 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Leukotriene receptor antagonists do not improve lung function decline in COPD: a meta-analysis.
Authors: Liu L, Wang JL, Xu XY, Feng M, Hou Y, Chen L Abstract OBJECTIVE: Leukotriene receptor antagonists (LTRA), the anti-inflammatory agents, have been reported new therapeutic value in chronic obstructive pulmonary disease (COPD). However, the effects of LTRA on lung function decline in COPD were determined with inconsistent results and a meta-analysis is needed. MATERIALS AND METHODS: Published cohort or randomized controlled studies were retrieved from PubMed and Embase databases. RESULTS: Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated in a random effects mo...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

JAK/STAT5 signaling pathway inhibitor ruxolitinib reduces airway inflammation of neutrophilic asthma in mice model.
CONCLUSIONS: Ruxolitinib may suppress the survival of Th17 cells by inhibiting the JAK/STAT5 signaling pathway and regulate the anti-apoptosis proteins Bcl-2 and Caspase3, thus promoting the increase of Thl7 cells entering the apoptotic pathway and reducing airway inflammation in NA mice. PMID: 29461617 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

TMS as tool to investigate the effect of pharmacological medications on cortical plasticity.
Authors: Caipa A, Alomar M, Bashir S Abstract The application of medications with a well-defined mode of action on a neurotransmitter or neuromodulator of the central nervous system (CNS) can be utilized to test the pharmaco-physiological properties of transcranial magnetic stimulation (TMS) on cortical excitability and plasticity. Similarly, a physiologically well-defined TMS measure of cortical excitability may be exploited to study a particular drug's effect at the level of the cerebrum. In this review, we aim to assess the impact of calcium channel blockers, Selective Serotonin Reuptake Inhibitors (SSRIs), and ...
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-200c suppressed cervical cancer cell metastasis and growth via targeting MAP4K4.
CONCLUSIONS: miR-200c could suppress cervical cancer cell proliferation and progression via regulating MAP4K4, which might provide a new target for cervical cancer diagnosis and therapy. PMID: 29461619 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Upregulation of LINC00346 in non-small cell lung cancer cells.
Authors: Rossi P, Ratto D, Occhinegro A PMID: 29424883 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Clinical research on one-third dose verteporfin photodynamic therapy in the treatment of chronic central serous chorioretinopathy.
Authors: Hua L, Lin B, Hong J, Min HB, Han WL, Zhou TY, Zhang ZQ Abstract OBJECTIVE: To observe the curative effect and safety of one-third dose Verteporfin photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A total of 60 patients (68 eyes) treated in our hospital from January 2016 to December 2016 were selected in this study, and they were diagnosed with chronic CSC via fluorescein fundus angiography (FFA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT). Besides, patients were treated with one-third conventional dose...
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Use of balloon catheter dilation vs. traditional endoscopic sinus surgery in management of light and severe chronic rhinosinusitis of the frontal sinus: a multicenter prospective randomized study.
CONCLUSIONS: BCD and ESS are two alternative weapons in the baggage of every endoscopic surgeon, even because they present similar outcomes, safeness and effectiveness both in light/mild and moderate/severe chronic rhinosinusitis of the frontal sinus. An interesting result of our study was the statistically significant better outcome of SNOT-20 score in patients that underwent BCD of frontal sinus for a moderate/severe CRS, compared to those that underwent a traditional ESS. PMID: 29424885 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-599 as a potential biomarker for prognosis of glioma.
This study aimed to determine the expression level of miRR-599 in glioma and to further investigate its clinical significance. PATIENTS AND METHODS: The expression levels of miR-599 were evaluated in 184 paired of glioma and normal tissues by Real-time RT-PCR. The correlation between tumor miR-599 expression and the clinical and pathological features was analyzed using x2 test. Overall survival and progression-free survival curves were obtained using the Kaplan-Meier method. Cox regression analysis was conducted to analyze the prognostic value of miR-599. RESULTS: We observed that miR-599 expression was significant...
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MiR-205 enhances cisplatin sensitivity of glioma cells by targeting E2F1.
CONCLUSIONS: These findings suggest that down-regulation of miR-205 confers the cisplatin resistance in glioma cells via upregulation of E2F1. It might serve as a candidate for glioma therapy. PMID: 29424887 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Effect of TAGLN2 in the regulation of meningioma tumorigenesis and development.
CONCLUSIONS: TAGLN2 can affect the proliferation, invasion and apoptosis of meningioma cells and may participate in the development of meningioma through regulating the PI3K/AKT signaling pathway. PMID: 29424888 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

LncRNA colon cancer-associated transcript 1 (CCAT1) promotes proliferation and metastasis of ovarian cancer via miR-1290.
CONCLUSIONS: In this study, we found that lncRNA CCAT1 could sponge miR-1290 in ovarian cancer, and was closely related to prognosis, proliferation, and metastasis. PMID: 29424889 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

miRNA211 induces apoptosis of cervical cancer SiHa cells via down-regulation of inhibitor of apoptosis proteins.
Authors: Liu YL, Wang GQ, Cui HX, Li XX, Xu ZL, Wang XY Abstract OBJECTIVE: Cervical cancer severely threatens patients' lives. MicroRNAs contribute to regulatory function in the growth and apoptosis of cells. The present study investigated the effect of miRNA211 on growth and apoptosis of cervical cancer SiHa cells. MATERIALS AND METHODS: miRNA211 and control miRNA were synthesized and transfected into cervical cancer SiHa cells. MTT assay and flow cytometry were used to study the effect of miRNA211 on growth and apoptosis of SiHa cells. RT-PCR and Western blot were used to detect the expression of inhibitor o...
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Autophagy suppresses the proliferation of renal carcinoma cell.
CONCLUSIONS: Our data indicated that autophagy could suppress the growth of RCC cells in vivo and in vitro, and autophagy appeared to be a new therapeutic target for treating advanced renal cell carcinoma. PMID: 29424891 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A novel prognostic biomarker for cholangiocarcinoma: circRNA Cdr1as.
CONCLUSIONS: Our finding suggested that circRNA Cdr1as may serve as a potential vicious molecular biomarker to predict the aggressive tumor progression and worse prognosis for CCA patients. PMID: 29424892 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The ten commandments of chemoembolization: expert discussion and report from Mediterranean Interventional Oncology (MIOLive) congress 2017.
Authors: Malagari K, Iezzi R, Goldberg SN, Bilbao JI, Sami A, Akhan O, Giuliante F, Pompili M, Crocetti L, Valentini V, Gasbarrini A, Colosimo C, Manfredi R Abstract Transarterial therapies in the setting of primary and secondary liver malignancies are becoming an essential part of the oncology landscape. The mechanism of action of c-TACE is the induction of tumor necrosis due to the high concentration of the chemotherapeutic that is delivered only locally and to the embolic effect that causes ischemia and increased dwell time of the chemotherapeutic in the tumor. Recently, DEB-TACE has emerged as a variation of c-...
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Twist2 and CD24 expression alters renal microenvironment in obesity associated kidney cancer.
CONCLUSIONS: The correlation between Twist2 and CD24 expression conclude that Twist2 overexpression in initial stage augments CD24 to express more in the latter stage of kidney cancer. Reversely, the overexpression of CD24 and down-regulation of Twist2 in later stages of kidney cancer suggest the CD24 expression is dependent on Twist2 expression level. PMID: 29424894 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research