Circ_0001982 accelerates the progression of colorectal cancer via sponging microRNA-144
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2458. doi: 10.26355/eurrev_202103_25394.ABSTRACTThe article "Circ_0001982 accelerates the progression of colorectal cancer via sponging microRNA-144, by Q. Deng, C.-J. Wang, R. Hao, Q.-Y. Yang, published in Eur Rev Med Pharmacol Sci 2020; 24 (4): 1755-1762-DOI: 10.26355/eurrev_202002_20352-PMID: 32141543" has been withdrawn from the authors due to some inaccuracies about pictures and data (Figures 2C and 2D need to be further confirmed). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/20352.PMID:33829421 | DOI:10.26355...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Q Deng C-J Wang R Hao Q-Y Yang Source Type: research

MOTS-c accelerates bone fracture healing by stimulating osteogenesis of bone marrow mesenchymal stem cells via positively regulating FOXF1 to activate the TGF- β pathway
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2459. doi: 10.26355/eurrev_202103_25396.ABSTRACTThe article "MOTS-c accelerates bone fracture healing by stimulating osteogenesis of bone marrow mesenchymal stem cells via positively regulating FOXF1 to activate the TGF-β pathway, by F.-B. Weng, L.-F. Zhu, J.-X. Zhou, Y. Shan, Z.-G. Tian, L.-W. Yang, published in Eur Rev Med Pharmacol Sci 2019; 23 (24): 10623-10630-DOI: 10.26355/eurrev_201912_19759-PMID: 31858528" has been withdrawn from the authors due to inaccuracies during the process of organizing the images. The Publisher apologizes for any inconvenience this ma...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: F-B Weng L-F Zhu J-X Zhou Y Shan Z-G Tian L-W Yang Source Type: research

LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2460. doi: 10.26355/eurrev_202103_25398.ABSTRACTThe article "LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway, by Y. Lei, Y.-H. Wang, X.-F. Wang, J. Bai, published in Eur Rev Med Pharmacol Sci 2018; 22 (19): 6315-6323-DOI: 10.26355/eurrev_201810_16042-PMID: 30338799" has been withdrawn from the authors due to inaccuracies and mistakes throughout the paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16042.PMID:33829423 | DOI:10.26355/eurrev_202103_25398 (Source: European Review for ...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Y Lei Y-H Wang X-F Wang J Bai Source Type: research

MicroRNA-130b-5p accelerates the migration and invasion of osteosarcoma via binding to TIMP2
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2461. doi: 10.26355/eurrev_202103_25400.ABSTRACTThe article "MicroRNA-130b-5p accelerates the migration and invasion of osteosarcoma via binding to TIMP2, by Z.-H. Cheng, C. Luo, Z.-L. Guo, published in Eur Rev Med Pharmacol Sci 2019; 23 (21): 9267-9276-DOI: 10.26355/eurrev_201911_19419-PMID: 31773678" has been withdrawn from the authors stating that "some data has to be verified by future research". The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19419.PMID:33829424 | DOI:10.26355/eurrev_202103_25400 (Source...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Z-H Cheng C Luo Z-L Guo Source Type: research

LncRNA PAPAS aggravates the progression of gastric cancer through regulating miRNA-188-5p
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2462. doi: 10.26355/eurrev_202103_25402.ABSTRACTSince this paper presents several inaccuracies and mistakes, the article "LncRNA PAPAS aggravates the progression of gastric cancer through regulating miRNA-188-5p, by X. Shi, X. You, W.-C. Zeng, Y.-J. Deng, H.-L. Hong, O.-X. Huang, M.-F. Wang, published in Eur Rev Med Pharmacol Sci 2019; 23 (24): 10761-10768-DOI: 10.26355/eurrev_201912_19778-PMID: 31858543" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19778.PMID:33829425 | DOI:10.26355/eurrev_20210...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: X Shi X You W-C Zeng Y-J Deng H-L Hong O-X Huang M-F Wang Source Type: research

MicroRNA-124 inhibits proliferation and metastasis of esophageal cancer via negatively regulating NRP1
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2457. doi: 10.26355/eurrev_202103_25392.ABSTRACTThis paper presents several inaccuracies and mistakes. Therefore, the article "MicroRNA-124 inhibits proliferation and metastasis of esophageal cancer via negatively regulating NRP1, by R.-K. Zang, J.-B. Ma, Y.-C. Liang, Y. Wang, S.-L. Hu, Y. Zhang, W. Dong, W. Zhang, L.-K. Hu, published in Eur Rev Med Pharmacol Sci 2018; 22 (14): 4532-4541-DOI: 10.26355/eurrev_201807_15508-PMID: 30058693" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15508.PMID:3382...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: R-K Zang J-B Ma Y-C Liang Y Wang S-L Hu Y Zhang W Dong W Zhang L-K Hu Source Type: research

Author Correction: Waist circumference and the risk of lumbar and femur fractures: a nationwide population-based cohort study
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2463. doi: 10.26355/eurrev_202103_25404.ABSTRACTCorrection to: European Review for Medical and Pharmacological Sciences 2021; 25 (3): 1198-1205-DOI: 10.26355/eurrev_202102_24822-PMID: 33629289, published online 15 February, 2021. After publication, the authors requested to correct Table I and some minor errors in the text. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/24822.PMID:33829427 | DOI:10.26355/eurrev_202103_25404 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: G R Park H S Kim Y T Kim H J Chung S J Ha D W Kim D R Kang J Y Kim M Y Lee J Y Lee Source Type: research

Transparency of disinfectant and hand sanitizer contents in the context of COVID-19
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2464-2467. doi: 10.26355/eurrev_202103_25391.NO ABSTRACTPMID:33829428 | DOI:10.26355/eurrev_202103_25391 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: N Cimolai Source Type: research

Leading cause of death in comparison to COVID-19 in Saudi Arabia
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2468-2469. doi: 10.26355/eurrev_202103_25406.NO ABSTRACTPMID:33829429 | DOI:10.26355/eurrev_202103_25406 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: S Bashir N Altwaijri T M Al-Harbi T Abualait Source Type: research

Ozone therapy may be an option for COVID-19 patients
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2470-2472. doi: 10.26355/eurrev_202103_25407.NO ABSTRACTPMID:33829430 | DOI:10.26355/eurrev_202103_25407 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Şahin F Eryilmaz H H Keser Şahin Source Type: research

Comment on safety and efficacy of oral lopinavir/ritonavir in pediatric patients with coronavirus disease: a nationwide comparative analysis
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2473-2474. doi: 10.26355/eurrev_202103_25408.NO ABSTRACTPMID:33829431 | DOI:10.26355/eurrev_202103_25408 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Ceccarelli P Pavone E Venanzi Rullo G Nunnari Source Type: research

Antifungal cerebrospinal levels and susceptibility profile in cryptococcal meningitis in the context of intracranial hypertension
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2475-2477. doi: 10.26355/eurrev_202103_25409.NO ABSTRACTPMID:33829432 | DOI:10.26355/eurrev_202103_25409 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: F Wirth D Pr íscila P Rosa A Val ério L Z Goldani Source Type: research

Polyautoimmunity (Psoriasis, Sjogren's syndrome, and autoimmune uveitis) following polymethylmethacrylate injection
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2478-2480. doi: 10.26355/eurrev_202103_25410.NO ABSTRACTPMID:33829433 | DOI:10.26355/eurrev_202103_25410 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: J Freire de Carvalho Source Type: research

The impact of diabetes mellitus on mortality and infection outcomes in burn patients: a meta-analysis
CONCLUSIONS: The present systematic review and meta-analysis provides evidence regarding the high morbidity and mortality related outcomes for diabetic patients with burns. The present study confirms the findings of a previously published systematic review suggesting diabetes to be an important and independent risk factor delineating the prognostic outcome of burns.PMID:33829434 | DOI:10.26355/eurrev_202103_25411 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: B Yang Y-Q Cai X-D Wang Source Type: research

Value of metabolic parameters of primary lesions examined by 18F-FDG PET/CT for endometrial cancer in preoperative evaluation
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2493-2502. doi: 10.26355/eurrev_202103_25412.ABSTRACTOBJECTIVE: To evaluate metabolic parameters of primary lesions examined by 18F-FDG PET/CT (18Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography), including maximum standard uptake value (SUVmax), metabolic volume (MTV), and total lesion glycolysis (TLG).PATIENTS AND METHODS: 79 patients with endometrial cancer were selected as the subjects. They were diagnosed by histopathology in our hospital for the first time from January 2016 to December 2018. All the patients were examined by 18F-FDG PET/CT. Retrospective s...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Q-Z Gai Y-B Lv G-Y Li D-Q Zhang Z Gao X-H Fang Source Type: research

A conservative screening approach to kidney disease before contrast-enhanced computed tomography in outpatient population
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2503-2510. doi: 10.26355/eurrev_202103_25413.ABSTRACTOBJECTIVE: To determine the incidence of abnormal renal function in an outpatient population referred for contrast-enhanced computed tomography (CECT) and assess the risk factors that could be used to eliminate superfluous estimated glomerular filtration rate (eGFR) testing.PATIENTS AND METHODS: The following risk factors were assessed in random patients referred for outpatient CECT: age>60 years, diabetes mellitus, hypertension, anemia, congestive heart failure, and a history of kidney/urological disease or renal surgery. The...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: A Fathala S Almehemeid I Alkharji R Alrwais R Benkuddah J Aljahani Source Type: research

Application of CT perfusion imaging in NSCLC and its correlation with angiogenesis and lymph node metastasis
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2511-2516. doi: 10.26355/eurrev_202103_25414.ABSTRACTOBJECTIVE: To investigate the application of computed tomography (CT) perfusion imaging in non-small cell lung cancer (NSCLC) and its correlation with angiogenesis and lymph node metastasis.PATIENTS AND METHODS: A total of 100 patients with NSCLC were selected as the study subjects. They were admitted to our hospital from January 2013 to January 2018. All patients were examined by CT perfusion imaging after admission. The differences and correlations of CT perfusion imaging parameters between patients with different angiogenesis ...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Y-S Chen W-H Lin A-L Zhang Y Lin Source Type: research

LncRNA PCAT-1 promotes the progression of osteosarcoma via miR-508-3p/ZEB1 axis
CONCLUSIONS: All data demonstrated that PCAT-1 promoted OS progression, and miR-508-3p/ZEB1 axis was implicated in the functional roles of PCAT-1 in OS, suggesting that PCAT-1/miR-508-3p/ZEB1 might serve as candidate therapeutic targets for OS patients.PMID:33829438 | DOI:10.26355/eurrev_202103_25415 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: L Chang D-L Jia C-S Cao H Wei Z-Q Li Source Type: research

PAX5-induced upregulation of LINC01194 exerts oncogenic properties by regulating GOLPH3 expression via miR-486-5p in prostate cancer
CONCLUSIONS: Our study identifies LINC01194 as a tumor promotor in PCa and implicates the LINC01194/miR-486-5p/GOLPH3 axis in the PCa progression.PMID:33829439 | DOI:10.26355/eurrev_202103_25416 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: H-R Song X-B Guo Y Duan H-Y Meng Z-Y Wang Source Type: research

Long-term survival case of a non-small cell lung cancer bone metastasis patient treated with bone cement, radiation and gefitinib
CONCLUSIONS: The median survival time for NSCLC patients with bone metastases is often less than 1 year. We reported the patient with more than eight years of survival, showed that some special cases can adopt the methods of local treatment including bone cement, treatment benefit patients, radiation therapy and targeted therapy in clinic to expand the survival.PMID:33829440 | DOI:10.26355/eurrev_202103_25417 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: W-T Hou X-Q Xie Y Luo C Yi F Luo J-B Kang F Wang Y Lu Y-L Gong D-B Wu B-L Qu Source Type: research

Basics for surgeons about the immunohistochemistry role in pancreatic NETs diagnosis
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2548-2553. doi: 10.26355/eurrev_202103_25418.ABSTRACTPancreatic neuroendocrine tumors (pNETs) are neuroendocrine tumors primarily found in the pancreas and upper small intestine. There are ten different pNETs: nine of these are associated with a specific functional syndrome, while one is not associated with a specific hormonal syndrome, and it is called non-functional. Up to 90% of pNETs are classified as non-functional. Immunohistochemistry is essential to define the diagnosis. However, to have a correct and reliable diagnosis, the pathologist must have adequately collected and tr...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: L Romano A Giuliani V Vicentini M Schietroma F Carlei Source Type: research

Drug-eluting bead bronchial arterial chemoembolization vs. chemotherapy in treating advanced non-small cell lung cancer: comparison of treatment efficacy, safety and quality of life
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2554-2566. doi: 10.26355/eurrev_202103_25419.ABSTRACTOBJECTIVE: This present study aimed to compare the treatment response, survival profile, quality of life (QoL), and safety between drug-eluting bead bronchial arterial chemoembolization (DEB-BACE) and chemotherapy in the treatment of advanced non-small-cell lung cancer (NSCLC).PATIENTS AND METHODS: Totally, 44 advanced NSCLC patients were analyzed retrospectively and were divided into DEB-BACE group (n=23) and chemotherapy group (n=21). Treatment response, European Organization for Research and Treatment of Cancer QoL Questionnai...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: X-F Liu H Lin Q Wang M Mu P Pan F-F Tian R Zhang W-G Zhao P-T Bao Source Type: research

LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma
CONCLUSIONS: Taken together, our findings validated that PCAT1 acted as completive endogenous RNA by sponging miR-508-3p and upregulating NFIB to facilitate DLBCL cell proliferation, migration and invasion.PMID:33829443 | DOI:10.26355/eurrev_202103_25420 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Tian Y Li W Zheng Q-Q Liu X-L Zhang J-L Liu S Zhang Y-X Sheng C-B Fan W-L Zhang Source Type: research

Hypomethylating agents for elderly patients with acute myeloid leukemia: a PRISMA systematic review and meta-analysis
This study aimed to identify if HMAs have therapeutic advantages compared with conventional care regimens (CCR) or placebo in elderly AML patients.MATERIALS AND METHODS: We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials from inception to November July 15, 2020. Randomized controlled trials that compared the efficacy and adverse events associated with HMAs, CCR, or placebo were searched. RevMan 5.3 software was used to calculate the hazard ratio (HR) and risk ratio (RR) with a 95% confidence interval (CI).RESULTS: Seven trials with a total of 1966 participants were included. Meta-...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: R-J Zhang J-H Zhai Z-J Zhang L-H Yang M-F Wang C-X Dong Source Type: research

Analysis of the relationship between personality traits and Internet addiction
CONCLUSIONS: The type of personality of the studied women implicated relationships to Internet addiction. Neuroticism might be a personality trait that particularly predisposes to an increased risk of Internet addiction. Openness to experience was conducive to Internet addiction. Conscientiousness negatively correlated with Internet addiction.PMID:33829445 | DOI:10.26355/eurrev_202103_25422 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: K Rachubi ńska A Cybulska M Szkup E Grochans Source Type: research

Probiotic intake unmasking a gastro-pleural fistula
CONCLUSIONS: Although gastropleural fistula is rare, it is necessary to include this pathological condition in the differential diagnosis of a persistent complicated pneumonia, because early diagnosis and, consequently, surgical management, may significantly impact on the prognosis of these patients. In our case, the detection of probiotics bacteria in the pleural fluid helped us to suspect and to look for the fistula.PMID:33829446 | DOI:10.26355/eurrev_202103_25423 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: A Gallo L di Gialleonardo F Lococo A Biondi M Montalto Source Type: research

Prevalence and risk factors of pulmonary embolism in acute exacerbation of chronic obstructive pulmonary disease and its impact on outcomes: a systematic review and meta-analysis
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2604-2616. doi: 10.26355/eurrev_202103_25424.ABSTRACTOBJECTIVE: The current study aimed to pool data for the prevalence of pulmonary embolism (PE) in acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). We also aimed to assess the risk factors of PE and its impact on the outcomes of AE-COPD.MATERIALS AND METHODS: PubMed, Embase, and CENTRAL databases were searched up to 1st January 2021 for prospective, retrospective, and cross-sectional studies reporting the prevalence of PE in AE-COPD based on computed tomography (CT) data.RESULTS: Sixteen studies were included....
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: J Wang Y-M Ding Source Type: research

Early and midterm results of the retrograde transpopliteal approach as the first-line treatment for total occlusions of iliofemoral arteries
CONCLUSIONS: With respectable early and midterm results, the retrograde popliteal artery approach can be considered a primary treatment option for iliac or femoropopliteal arteries' recanalization in selected patients.PMID:33829448 | DOI:10.26355/eurrev_202103_25425 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: A Ü Yener A Yal çınkaya Ö Yener Ö F Çiçek M C Çiçek Source Type: research

Advances in studies on exosomes and microvesicles as markers of cardiovascular disease
This article summarizes various signal transmission pathways of exosomes and MVs in cardiovascular diseases, as well as their application and suggestions in the diagnosis of cardiovascular diseases.PMID:33829449 | DOI:10.26355/eurrev_202103_25426 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: L Fu S-S Wu Source Type: research

Inhibitory effects of epigallocatechin gallate (EGCG) combined with zinc sulfate and silver nanoparticles on avian influenza A virus subtype H5N1
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2630-2636. doi: 10.26355/eurrev_202103_25427.ABSTRACTOBJECTIVE: Even though antiviral drugs against H5N1 flu infection are accessible, they are still limited by antiviral drug resistance and unfavorable side effects. Thus, this work tested the action of epigallocatechin gallate (EGCG) co-administered with both zinc (II) ions and silver nanoparticles (AgNPs).MATERIALS AND METHODS: EGCG was used with both zinc sulfate (zinc II) and silver nanoparticles to test their antiviral activities against avian flu subtype H5N1 in embryonated SPF eggs. The MTS test was used to determine the cyt...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M J Saadh S M Aldalaen Source Type: research

Prothrombin complex concentrates and andexanet for management of direct factor Xa inhibitor related bleeding: a meta-analysis
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2637-2653. doi: 10.26355/eurrev_202103_25428.ABSTRACTThere are potential concerns related to bleeding caused by oral anticoagulants, especially in the elderly. Andexanet alfa has been authorized for use to reverse the effects of oral anticoagulants. Off-label use of four factor prothrombin complex concentrate (4F-PCC) for the reversal of oral factor Xa inhibitors is common. However, not much is known about their efficacy and safety profile. The intent of this meta-analysis was to evaluate the efficacy and safety of 4F-PCC and andexanet alfa for management of major bleeding due to o...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: C Luo F Chen Y-H Chen C-F Zhao C-Z Feng H-X Liu D Zhu Q-Z Luo Source Type: research

JKAP correlates with lower disease risk and inflammation, and its increment during etanercept treatment associates with commendable treatment efficiency in rheumatoid arthritis patients
CONCLUSIONS: JKAP correlates with reduced disease risk and inflammation, and its increment during ETN treatment associates with commendable treatment efficiency in RA patients.PMID:33829452 | DOI:10.26355/eurrev_202103_25429 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: X-Y Mou D Jin Q Zhang J-T Guan Y Jin Source Type: research

Treatment of medication-related osteonecrosis of the jaw (MRONJ). A systematic review
CONCLUSIONS: Due to the low evidence level and the limited sample size of the studies included, the results of this review must be cautiously interpreted. However, they can be suggestive for evaluating the possible benefits of these treatment options in MRONJ management. Further prospective comparative studies with a large sample size are urgently needed to confirm the results.PMID:33829453 | DOI:10.26355/eurrev_202103_25430 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: F Goker E Grecchi F Grecchi L Francetti M Del Fabbro Source Type: research

Efficacy and safety of intrathecal morphine for pain control after spinal surgery: a systematic review and meta-analysis
This study aimed to assess the efficacy and safety of intrathecal (IT) morphine for postoperative pain control in adults undergoing spinal surgeries. We searched the electronic databases of PubMed, Embase, and CENTRAL up to 1st January 2021 for randomized controlled trials (RCTs) or controlled clinical trials (CCTs) comparing IT morphine with placebo or other analgesics. Twelve studies were included. Eleven were RCTs and one was a CCT. Our meta-analysis indicated a statistically significant reduction of pain scores with IT morphine at 2 hours, 4 hours, 6 hours, 8 hours, 12 hours, and 24 hours; but no significant difference...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: J Wang H Sun W-T Sun H-P Sun T Tian J Sun Source Type: research

The effect of statins on mortality among patients with infection: umbrella review of meta-analyses
CONCLUSIONS: The present review identified a protective effect of statins on infection-related mortality, but all available studies had a weak level of evidence. Therefore, further studies with a strong level of evidence are needed, and it is also necessary to investigate the types of statins and to study clinical outcomes other than mortality to gain further insights.PMID:33829455 | DOI:10.26355/eurrev_202103_25432 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: R A Ghayda C H Han K H Lee J S Kim S E Kim S H Hong M Kim A Kronbichler K Tizaoui H Li A Koyanagi L Jacob M S Kim D K Yon S W Lee K Kostev J I Shin J W Yang L Smith Source Type: research

The effect of statins on all-cause and cardiovascular mortality in patients with non-dialysis chronic kidney disease, patients on dialysis, and kidney transplanted recipients: an umbrella review of meta-analyses
CONCLUSIONS: Our finding indicates that statin could improve all-cause and cardiovascular mortality in patients with non-dialysis CKD.PMID:33829456 | DOI:10.26355/eurrev_202103_25433 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: R A Ghayda J Y Lee J W Yang C H Han G H Jeong S Yoon S H Hong K H Lee P Gauckler A Kronbichler W Kang J I Shin Source Type: research

Impact of nursing students on the quality of care perceived by patients: a systematic review of the literature
CONCLUSIONS: The studies under review show high levels of satisfaction among patients when nursing care is delivered through training, particularly when the patients who agree to be treated by nursing trainees have previous experience of hospitalization and relationships with trainees. Educational background and the empathy and communication skills of both professional nurses and trainees influence patients' perception of the quality of care and their satisfaction with it.PMID:33829457 | DOI:10.26355/eurrev_202103_25434 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: A Delli Poggi G Pintus S Dionisi E Di Simone N Giannetta M Di Muzio S Mardente L Tibaldi D Tartaglini F Consorti V D'Andrea Source Type: research

Ophthalmology practice in Afghanistan during the COVID-19 pandemic
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2726-2729. doi: 10.26355/eurrev_202103_25435.ABSTRACTThis short communication described the actions taken in ophthalmic practice in Kabul, Afghanistan during the COVID-19 pandemic to effectively protect both patients and staff. By following World Health Organisation (WHO), international and local guidelines it has been possible to continue treating ophthalmic outpatients with minimum risk to both patients and staff. The changes which have been implemented may allow better overall infection control in the hospital which will continue to have benefits post-pandemic.PMID:33829458 | DO...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Delsoz P Hollands Source Type: research

Ventilatory therapies and Intensive Care admissions for patients with COVID-19: a systematic review
CONCLUSIONS: COVID-19 has led to a high number of ICU admissions and a challenge for ICUs is to provide the best ventilatory therapy available to patients admitted. It has been observed that the available figures for ICU admissions and the use of ventilatory therapies are similar across continents. However, the data suggest that geographic areas with higher rates of ICU admission have lower mortality rates. The lack of information in some of the clinical records limits the ability to obtain more conclusive results.PMID:33829459 | DOI:10.26355/eurrev_202103_25436 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: I Morales-Can é M Del Roc ío Valverde-León J Gonz ález-Gancedo P M Rodr íguez-Muñoz P Hidalgo-Lopezosa M A Rodr íguez-Borrego P J L ópez-Soto Source Type: research

Worse impact of second wave COVID-19 pandemic in adults but not in children with inflammatory bowel disease: an Italian single tertiary center experience
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2744-2747. doi: 10.26355/eurrev_202103_25437.ABSTRACTOBJECTIVE: From September 2020, a second wave of COVID-19 pandemic started. We aimed at exploring the impact of SARS-CoV-2 infection in IBD patients during the two waves.PATIENTS AND METHODS: All IBD patients with a confirmed diagnosis of SARS-CoV-2 infection were enrolled. They were sorted into two groups (those infected before September 2020, and those from September 2020 to January 2021) and compared by demographic and clinical data.RESULTS: Twenty-five patients (out of about 600 with a follow-up visit) were infected with SARS...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: S Carparelli M R Pastore M R Valvano A Marseglia A Latiano O Palmieri M Guerra G Martino F Perri F Bossa Source Type: research

Post-COVID pulmonary fibrosis: therapeutic efficacy using with mesenchymal stem cells - How the lung heals
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2748-2751. doi: 10.26355/eurrev_202103_25438.ABSTRACTCOVID-19 is an acute respiratory infectious disease caused by SARS-COV 2 (Severe Acute Respiratory Syndrome Coronavirus) that has become a global pandemic. COVID-19 mainly causes the respiratory complications of Acute Respiratory Distress Syndrome (ARDS), cytokine storm, and severe immune disruptions. The assays depict that though people recuperate from COVID-19, there are still symptoms that persists in the body causing discomfort, which is the consequence of the viral infection due to severe immune disruptions. Upon various dif...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Vishnupriya M Naveenkumar K Manjima N V Sooryasree T Saranya S Ramya S Harysh Winster M Paulpandi V Balachandar N Arul Source Type: research

SARS-CoV-2 vaccine development: where are we?
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2752-2784. doi: 10.26355/eurrev_202103_25439.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proved to be one of the most challenging infectious diseases in the modern era, and despite several countermeasures to lessen its impact, the spread of the virus is still affecting most countries. This renders the goal of active immunization of the population through vaccination a worldwide public health priority. In fact, only when efficient vaccination programs will be successfully implemented, a return to...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Galdiero M Galdiero V Folliero C Zannella A De Filippis A Mali L Rinaldi G Franci Source Type: research

Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): preliminary results from a retrospective cohort study
CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.PMID:33829463 | DOI:10.26355/eurrev_202103_25440 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: G Vetrugno P Laurenti F Franceschi F Foti F D'Ambrosio M Cicconi D I LA Milia M Di Pumpo E Carini D Pascucci S Boccia R Pastorino G Damiani F De-Giorgio A Oliva N Nicolotti A Cambieri R Ghisellini R Murri G Sabatelli M Musolino A Gasbarrini Gemelli-Agains Source Type: research

SARS-CoV-2 infection and H1N1 vaccination: does a relationship between the two factors really exist? A retrospective analysis of a territorial cohort in Ferrara, Italy
CONCLUSIONS: In our groups of patients, we found a relationship between seasonal influenza vaccinations and SARS-CoV-2 infection. Age seems to be the main risk factor for short-term mortality in COVID-19 inpatients, while the influenza vaccination is, together with gender and age itself, a determining factor in predicting the need for hospitalization.PMID:33829464 | DOI:10.26355/eurrev_202103_25441 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: S Greco A Bella B Bonsi N Fabbri A Califano S Morrone P Chessa C Pistolesi G Zuliani F De Motoli R Manfredini A De Giorgi A Passaro Source Type: research

Therapeutic potential of N-acetyl cysteine (NAC) in preventing cytokine storm in COVID-19: review of current evidence
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2802-2807. doi: 10.26355/eurrev_202103_25442.ABSTRACTSince November 2019, SARS Coronavirus 2 disease (COVID-19) pandemic has spread through more than 195 nations worldwide. Though the coronavirus infection affects all age and sex groups, the mortality is skewed towards the elderly population and the cause of death is mostly acute respiratory distress syndrome (ARDS). There are data suggesting the role of excessive immune activation and cytokine storm as the cause of lung injury in COVID-19. The excessive immune activation and cytokine storm usually occurs due to an imbalance in red...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: R R Mohanty B M Padhy S Das B R Meher Source Type: research

Effects of increasing aerobic capacity on improving psychological problems seen in patients with COVID-19: a review
CONCLUSIONS: This review demonstrated that increasing the aerobic capacity is a recommended treatment for decreasing the psychological problems commonly seen in people with COVID-19 because it has the potential for decreasing psychological problems and improving immune functions which would help counter COVID-19.PMID:33829466 | DOI:10.26355/eurrev_202103_25443 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: M Amro A Mohamed M Alawna Source Type: research

Circ_0001982 accelerates the progression of colorectal cancer via sponging microRNA-144
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2458. doi: 10.26355/eurrev_202103_25394.ABSTRACTThe article "Circ_0001982 accelerates the progression of colorectal cancer via sponging microRNA-144, by Q. Deng, C.-J. Wang, R. Hao, Q.-Y. Yang, published in Eur Rev Med Pharmacol Sci 2020; 24 (4): 1755-1762-DOI: 10.26355/eurrev_202002_20352-PMID: 32141543" has been withdrawn from the authors due to some inaccuracies about pictures and data (Figures 2C and 2D need to be further confirmed). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/20352.PMID:33829421 | DOI:10.26355...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Q Deng C-J Wang R Hao Q-Y Yang Source Type: research

MOTS-c accelerates bone fracture healing by stimulating osteogenesis of bone marrow mesenchymal stem cells via positively regulating FOXF1 to activate the TGF- β pathway
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2459. doi: 10.26355/eurrev_202103_25396.ABSTRACTThe article "MOTS-c accelerates bone fracture healing by stimulating osteogenesis of bone marrow mesenchymal stem cells via positively regulating FOXF1 to activate the TGF-β pathway, by F.-B. Weng, L.-F. Zhu, J.-X. Zhou, Y. Shan, Z.-G. Tian, L.-W. Yang, published in Eur Rev Med Pharmacol Sci 2019; 23 (24): 10623-10630-DOI: 10.26355/eurrev_201912_19759-PMID: 31858528" has been withdrawn from the authors due to inaccuracies during the process of organizing the images. The Publisher apologizes for any inconvenience this ma...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: F-B Weng L-F Zhu J-X Zhou Y Shan Z-G Tian L-W Yang Source Type: research

LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2460. doi: 10.26355/eurrev_202103_25398.ABSTRACTThe article "LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway, by Y. Lei, Y.-H. Wang, X.-F. Wang, J. Bai, published in Eur Rev Med Pharmacol Sci 2018; 22 (19): 6315-6323-DOI: 10.26355/eurrev_201810_16042-PMID: 30338799" has been withdrawn from the authors due to inaccuracies and mistakes throughout the paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16042.PMID:33829423 | DOI:10.26355/eurrev_202103_25398 (Source: European Review for ...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Y Lei Y-H Wang X-F Wang J Bai Source Type: research

MicroRNA-130b-5p accelerates the migration and invasion of osteosarcoma via binding to TIMP2
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2461. doi: 10.26355/eurrev_202103_25400.ABSTRACTThe article "MicroRNA-130b-5p accelerates the migration and invasion of osteosarcoma via binding to TIMP2, by Z.-H. Cheng, C. Luo, Z.-L. Guo, published in Eur Rev Med Pharmacol Sci 2019; 23 (21): 9267-9276-DOI: 10.26355/eurrev_201911_19419-PMID: 31773678" has been withdrawn from the authors stating that "some data has to be verified by future research". The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19419.PMID:33829424 | DOI:10.26355/eurrev_202103_25400 (Source...
Source: European Review for Medical and Pharmacological Sciences - April 8, 2021 Category: Drugs & Pharmacology Authors: Z-H Cheng C Luo Z-L Guo Source Type: research