MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4647. doi: 10.26355/eurrev_202107_26368.ABSTRACTThe article "MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway, by S.-W. Wang, L.-X. Deng, H.-Y. Chen, Z.-Q. Su, S.-L. Ye, W.-Y. Xu, published in Eur Rev Med Pharmacol Sci 2018; 22 (2): 498-505-DOI: 10.26355/eurrev_201801_14201-PMID: 29424909" has been withdrawn from the authors due to inaccuracies (there are some errors and incorrect data). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S-W Wang L-X Deng H-Y Chen Z-Q Su S-L Ye W-Y Xu Source Type: research

MiR-1269a acts as an onco-miRNA in non-small cell lung cancer via down-regulating SOX6
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4648. doi: 10.26355/eurrev_202107_26371.ABSTRACTThe article "MiR-1269a acts as an onco-miRNA in non-small cell lung cancer via down-regulating SOX6, by R.-H. Jin, D.-J. Yu, M. Zhong, published in Eur Rev Med Pharmacol Sci 2018; 22 (15): 4888-4897- DOI: 10.26355/eurrev_201808_15625-PMID: 30070324" has been withdrawn from the authors to some technical reasons (there are some errors and incorrect data). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15625.PMID:34337710 | DOI:10.26355/eurrev_202107_26371 (Source: Europea...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: R-H Jin D-J Yu M Zhong Source Type: research

Comment on the article by Zaami et al "Increasing abuse of anabolic steroids and chemsex drugs as performance and image-enhancing agents". Eur Rev Med Pharmacol Sci 2021; 25: 455-458
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4649-4652. doi: 10.26355/eurrev_202107_26374.NO ABSTRACTPMID:34337711 | DOI:10.26355/eurrev_202107_26374 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: F Umani Ronchi M C Varone G Rallo Source Type: research

Cutis laxa after Mariana dam disaster in Brazil
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4653-4654. doi: 10.26355/eurrev_202107_26375.NO ABSTRACTPMID:34337712 | DOI:10.26355/eurrev_202107_26375 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: U Rebou ças Athayde J F de Carvalho Source Type: research

A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer
CONCLUSIONS: In sum, our study demonstrated that ELFN1-AS1 sponges miR-1205 to upregulate MTA1, which is essential for CRC cell proliferation, migration, and invasion as well as apoptosis induction.PMID:34337713 | DOI:10.26355/eurrev_202107_26376 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: L-Q Zhai X-X Wang C-X Qu L-Z Yang C-M Jia X-C Shi Source Type: research

LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer
CONCLUSIONS: This newly identified HOXA11-AS/miR-24-3p/JPT1 axis may provide novel angle for the better control of PCa.PMID:34337714 | DOI:10.26355/eurrev_202107_26377 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: Y Cheng H-Y Xiong Y-M Li H-R Zuo Y Liu G-L Liao Source Type: research

Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis
CONCLUSIONS: The present study confirmed a variable expression of the endocannabinoid system in human ovarian tumors. Cannabinoid Receptor Type 1 expression was significantly different in malignant epithelial ovarian tumors according to dualistic model of ovarian carcinogenesis. Thus, in the most aggressive types II ovarian tumors, Cannabinoid Receptor Type 1 expression resulted predominantly negative or weak.PMID:34337715 | DOI:10.26355/eurrev_202107_26378 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: A Ronchi F Grauso F Zito Marino V Quagliariello N Maurea G Facchini M Montopoli R Franco M Berretta E M Messalli Source Type: research

Iguratimod attenuates general disease activity and improves lung function in rheumatoid arthritis-associated interstitial lung disease patients
CONCLUSIONS: Iguratimod attenuates general inflammation, disease activity, and improves lung function in RA-ILD patients.PMID:34337716 | DOI:10.26355/eurrev_202107_26379 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: P Shu S-Q Shao X-N Cai D-M Zhou H Ma L Lu H-Q Yin S-L Yin Source Type: research

Towards real-time diagnosis for pediatric sepsis using graph neural network and ensemble methods
CONCLUSIONS: The prediction model toward a real-time diagnosis of sepsis shows more accurate predictions at each stage compared to other control methods. When the first two stages of data are obtained as input, the model accuracy is close to using complete test data, which can help compress the time to diagnosis to about an hour after the test and significantly reduce waiting time.PMID:34337717 | DOI:10.26355/eurrev_202107_26380 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: X Chen R Zhang X-Y Tang Source Type: research

Efficacy of suprascapular nerve blocks for management of hemiplegic shoulder pain: a systematic review and meta-analysis
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4702-4713. doi: 10.26355/eurrev_202107_26381.ABSTRACTOBJECTIVE: To compare the efficacy of suprascapular nerve block (SSNB) with other treatment modalities for management of HSP in terms of relieving pain and improving range of motion of shoulder joints.MATERIALS AND METHODS: An electronic search was carried out in PubMed, CENTRAL, SCOPUS and EMBASE databases using a series of relevant keywords, along with a manual search. Randomized clinical trials comparing the efficacy of SSNB with placebo injections, intra-articular injections (IAI), ultrasound and Pulsed RF were identified. T...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: Y-G Wang Y-D Fu N-J Zhou J-K Yang Source Type: research

One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis
CONCLUSIONS: Taken together, these results demonstrate that F. nucleatum is mechanically, biologically and clinically connected to NEC. LncRNA ENO1-IT1 may be important targets for F. nucleatum in NEC-inflammation, and a meaningful in treating patients with Neonatal NEC with elevated F. nucleatum.PMID:34337719 | DOI:10.26355/eurrev_202107_26382 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: J-C Lin X-Y Ma J-Y Liu Y-Z Luo L Lin L-Y Zhang Source Type: research

Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention
CONCLUSIONS: Furosemide combined with hydration therapy has no significant effect on the incidence of CI-AKI in patients after coronary intervention but can reduce the incidence of MACEs and mortality, thereby providing clinical benefits.PMID:34337720 | DOI:10.26355/eurrev_202107_26383 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: M-J Hu E-F Luo C-C Tang L Wang Q-G Zhang J-B Gong Source Type: research

A novel modification of frozen elephant trunk technique: unique protocol from one institution
CONCLUSIONS: Our modification of FET technique was feasible, effective, and safe, with good postoperative outcomes.PMID:34337721 | DOI:10.26355/eurrev_202107_26384 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: D H S Phung T S Nguyen H-L Vo N T Vu N T Duong V L Pham Q H Doan H U Nguyen Source Type: research

Pathophysiology and management of Akathisia 70 years after the introduction of the chlorpromazine, the first antipsychotic
CONCLUSIONS: Pharmacological management may pose a challenge in chronic akathisia. Rotation between different pharmacological management strategies may be optimal in resistant cases. Discontinuation of the causative drug and use of b-blockers, mirtazapine, benzodiazepines or gabapentinoids for symptomatic relief is the basis of management.PMID:34337722 | DOI:10.26355/eurrev_202101_26386 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: N Zareifopoulos M Katsaraki P Stratos V Villiotou M Skaltsa A Dimitriou M Karveli P Efthimiou M Lagadinou D Velissaris Source Type: research

Potential mechanisms of metformin-induced memory impairment
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4757-4761. doi: 10.26355/eurrev_202107_26387.ABSTRACTMetformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus. In addition to its ability to lower glucose levels, it has recently been reported to be potentially useful for the treatment of other conditions because of its anticancer activity, cardiovascular protective effect, neuroprotective effect, and efficacy in the treatment of polycystic ovary syndrome. However, long-term use of metformin may lead to side-effects such as memory impairment. Here, we critically review the effect of metformin on...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: A Alhowail Source Type: research

PCSK9 and inflammatory biomarkers in the early post kidney transplantation period
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4762-4772. doi: 10.26355/eurrev_202107_26388.ABSTRACTOBJECTIVE: Various biomarkers have been studied in the early post-kidney transplantation (post-KTx) period in order to identify potential therapeutic targets for improving long-term graft survival. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a biomarker that has recently gained interest in cardiovascular disease but its role still remains to be defined post-KTx.PATIENTS AND METHODS: We prospectively evaluated the levels of PCSK9, interleukin (IL)-6, WBC and C-reactive protein in seventy-three hemodialysis patients u...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: C Melexopoulou S Marinaki E Oikonomou M J Bonios P Theofilis A Miliou G Siasos D Tousoulis J N Boletis Source Type: research

Efficacy and effect of intracameral adrenaline infusion on pulse rate and blood pressure during phacoemulsification in patients with dark irides
Eur Rev Med Pharmacol Sci. 2021 Jan;25(14):4773-4778. doi: 10.26355/eurrev_202101_26389.ABSTRACTOBJECTIVE: Phacoemulsification is the most common cataract surgery that needs optimum circumstances in the field of surgery. This comparative pre- and postoperative study assessed the efficacy and safety of using adrenaline in the irrigating solution as an adjunct to preoperative topical mydriatics in dark irides during Phaco surgery.PATIENTS AND METHODS: This was a prospective observational study that enrolled 421 cataract patients (421 eyes) with dark irides, who were scheduled for Phaco surgery from January 2019 to August 202...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: K M Alabdulwahhab Source Type: research

Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial
CONCLUSIONS: Although the perioperative administration of parecoxib did not provide significantly better postoperative pain control or reduce the opioid requirement relative to placebo, its use led to a shorter hospital stay.PMID:34337726 | DOI:10.26355/eurrev_202107_26390 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: C Angthong S Manuwong V Singh P Rajbhandari A Veljkovic Source Type: research

A new and reliable landmark in parotid surgery: tragomastoid groove (Akil Groove)
CONCLUSIONS: The tragomastoid groove was defined for the first time in the literature as a reliable landmark for identifying the facial nerve truncus easily during parotid surgery.PMID:34337727 | DOI:10.26355/eurrev_202107_26391 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: F Akil V Kinis U Yilmaz M Akdag S F Toprak M Ayral H Durak Source Type: research

Endoscopic laser diverticulotomy in Zenker's diverticulum: experiences with basal wound sealing using a collagen-fibrin patch
CONCLUSIONS: These findings suggest that use of a collagen-fibrin sealant patch in endoscopic laser diverticulotomy may contribute to the safety of endoscopic controlled laser diverticulotomy without comprising the success rates.PMID:34337728 | DOI:10.26355/eurrev_202107_26392 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: M Koch V Thimsen M Traxdorf J Zenk H Iro E Treutlein K Mantsopoulos Source Type: research

The relevance of inositols treatment for PCOS before and during ART
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4799-4809. doi: 10.26355/eurrev_202107_26393.ABSTRACTPolycystic ovary syndrome (PCOS) is an endo-crine disorder that occurs in 8-10% of women of reproduc-tive age. It is characterized by oligo or anovulation, hyperandrogenism and/or polycystic ovaries, but also by an increased insulin plasma level especially in overweight/obese women or in those with familial diabetes. In the last years, among the insulin sensitizers, the use of the two active isoforms of inositols (myo-inositol and d-chiro-inositol) has been spreading for the treatment of PCOS insulin resistance. Several studies ...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: P G Artini E Malacarne V Tomatis A D Genazzani Source Type: research

Polypharmacy is a determinant of hospitalization in Parkinson's disease
CONCLUSIONS: Among patients with PD, the number of daily medications is associated with increased risk of hospitalization; an increasing number of drugs is associated with increasing number of hospitalizations.PMID:34337730 | DOI:10.26355/eurrev_202107_26394 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S Giovannini A Laudisio L Navarini M R Lo Monaco M Ciaburri E Serafini C Loreti D Coraci P Caliandro L Padua R Bernabei L Biscotti G Zuccal à Source Type: research

An automated synthesis of 177Lu-EDTMP as an efficient bone-seeking therapeutic radiopharmaceutical
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4829-4834. doi: 10.26355/eurrev_202107_26396.ABSTRACTOBJECTIVE: Radiolabeled bisphosphonates have found wide clinical use in nuclear medicine for palliative therapy of bone metastases. 177Lu-EDTMP was used to relieve metastatic bone pain in patients with breast or prostate cancer. The therapeutic efficacy of 177Lu-EDTMP at 1-, 3-, 6-, and 8-weeks post-therapy was evaluated using Standard Pain Scoring Assessment Criteria. In addition, toxicity was evaluated in terms of hematological parameters using the Common Terminology Criteria for Adverse Events V4.0.PATIENTS AND METHODS: A ful...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: U Elboga B Kilbas E Sahin Y B Cay ırlı K Eryilmaz T Begec H E Bakar G Mercanoglu Y Z Celen Source Type: research

The evaluation of the trachea as a new parameter in determining the prognosis of COVID-19: first pilot study
CONCLUSIONS: The tracheal diameter may increase in proportion to the severity of inflammation, indicating or accompanying a poor prognosis. Patients with extensive involvement should be monitored closely for the development of tracheal stenosis.PMID:34337732 | DOI:10.26355/eurrev_202107_26397 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S Ünlü M Ilgar M Ak çiçek Source Type: research

Liraglutide improves pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus by inhibiting the IKKε/NF-κB pathway
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4818-4828. doi: 10.26355/eurrev_202107_26395.ABSTRACTOBJECTIVE: The purpose of this study was to explore the effect of liraglutide on pancreatic islet β cell apoptosis in rats with type 2 diabetes mellitus (T2DM) and the potential mechanisms.MATERIALS AND METHODS: SD rats were randomly divided into control group, model group, and liraglutide groups (200 and 100 μg/(kg·d)). Rats were fed with high sugar and high-fat diet for 8 weeks, and then streptozotocin (STZ) 40 mg/kg was intraperitoneally injected to establish T2DM model. After successful modeling, rats in the i...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: Y-T Liu T He H-Q Li P Jiang Source Type: research

Plasma convalescent decrease mortality in COVID-19 patients: a systematic review and meta-analysis
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4841-4853. doi: 10.26355/eurrev_202107_26398.ABSTRACTOBJECTIVE: To investigate the role of Convalescent Plasma (CP) in reducing mortality of COVID-19 patients.MATERIALS AND METHODS: A systematic literature search was conducted from PubMed, Embase, Medrxiv, and Google Scholar from April and finalized in December 2020 using the following terms: covid-19, convalescent plasma, cp, ccp, copla. The studies were screened, extracted, and evaluated by two authors independently. Comparative retrospective or prospective studies with a control group were included. Mortality was defined as the...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: A Yuwono Soeroto A Purwiga A Alam D Prasetya Source Type: research

Should we be concerned when COVID-19-positive patients take opioids to control their pain? Insights from a pharmacological point of view
CONCLUSIONS: Clinicians should keep in mind the frequent DDIs with drugs extensively metabolized by the CYP450 system and prefer opioids undergoing a limited hepatic metabolism. Identification and management of DDIs and dissemination of the related knowledge should be a major goal in the delivery of chronic care to ensure optimized patient outcomes and facilitate updating recommendations for COVID-19 therapy in frail populations, namely comorbid, poly-medicated patients or individuals suffering from substance use disorder.PMID:34337735 | DOI:10.26355/eurrev_202107_26399 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S Natoli R Carpenedo E Chin è F Vannicola F Leonardis M Dauri Source Type: research

MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4647. doi: 10.26355/eurrev_202107_26368.ABSTRACTThe article "MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway, by S.-W. Wang, L.-X. Deng, H.-Y. Chen, Z.-Q. Su, S.-L. Ye, W.-Y. Xu, published in Eur Rev Med Pharmacol Sci 2018; 22 (2): 498-505-DOI: 10.26355/eurrev_201801_14201-PMID: 29424909" has been withdrawn from the authors due to inaccuracies (there are some errors and incorrect data). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S-W Wang L-X Deng H-Y Chen Z-Q Su S-L Ye W-Y Xu Source Type: research

MiR-1269a acts as an onco-miRNA in non-small cell lung cancer via down-regulating SOX6
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4648. doi: 10.26355/eurrev_202107_26371.ABSTRACTThe article "MiR-1269a acts as an onco-miRNA in non-small cell lung cancer via down-regulating SOX6, by R.-H. Jin, D.-J. Yu, M. Zhong, published in Eur Rev Med Pharmacol Sci 2018; 22 (15): 4888-4897- DOI: 10.26355/eurrev_201808_15625-PMID: 30070324" has been withdrawn from the authors to some technical reasons (there are some errors and incorrect data). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15625.PMID:34337710 | DOI:10.26355/eurrev_202107_26371 (Source: Europea...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: R-H Jin D-J Yu M Zhong Source Type: research

Comment on the article by Zaami et al "Increasing abuse of anabolic steroids and chemsex drugs as performance and image-enhancing agents". Eur Rev Med Pharmacol Sci 2021; 25: 455-458
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4649-4652. doi: 10.26355/eurrev_202107_26374.NO ABSTRACTPMID:34337711 | DOI:10.26355/eurrev_202107_26374 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: F Umani Ronchi M C Varone G Rallo Source Type: research

Cutis laxa after Mariana dam disaster in Brazil
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4653-4654. doi: 10.26355/eurrev_202107_26375.NO ABSTRACTPMID:34337712 | DOI:10.26355/eurrev_202107_26375 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: U Rebou ças Athayde J F de Carvalho Source Type: research

A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer
CONCLUSIONS: In sum, our study demonstrated that ELFN1-AS1 sponges miR-1205 to upregulate MTA1, which is essential for CRC cell proliferation, migration, and invasion as well as apoptosis induction.PMID:34337713 | DOI:10.26355/eurrev_202107_26376 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: L-Q Zhai X-X Wang C-X Qu L-Z Yang C-M Jia X-C Shi Source Type: research

LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer
CONCLUSIONS: This newly identified HOXA11-AS/miR-24-3p/JPT1 axis may provide novel angle for the better control of PCa.PMID:34337714 | DOI:10.26355/eurrev_202107_26377 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: Y Cheng H-Y Xiong Y-M Li H-R Zuo Y Liu G-L Liao Source Type: research

Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis
CONCLUSIONS: The present study confirmed a variable expression of the endocannabinoid system in human ovarian tumors. Cannabinoid Receptor Type 1 expression was significantly different in malignant epithelial ovarian tumors according to dualistic model of ovarian carcinogenesis. Thus, in the most aggressive types II ovarian tumors, Cannabinoid Receptor Type 1 expression resulted predominantly negative or weak.PMID:34337715 | DOI:10.26355/eurrev_202107_26378 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: A Ronchi F Grauso F Zito Marino V Quagliariello N Maurea G Facchini M Montopoli R Franco M Berretta E M Messalli Source Type: research

Iguratimod attenuates general disease activity and improves lung function in rheumatoid arthritis-associated interstitial lung disease patients
CONCLUSIONS: Iguratimod attenuates general inflammation, disease activity, and improves lung function in RA-ILD patients.PMID:34337716 | DOI:10.26355/eurrev_202107_26379 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: P Shu S-Q Shao X-N Cai D-M Zhou H Ma L Lu H-Q Yin S-L Yin Source Type: research

Towards real-time diagnosis for pediatric sepsis using graph neural network and ensemble methods
CONCLUSIONS: The prediction model toward a real-time diagnosis of sepsis shows more accurate predictions at each stage compared to other control methods. When the first two stages of data are obtained as input, the model accuracy is close to using complete test data, which can help compress the time to diagnosis to about an hour after the test and significantly reduce waiting time.PMID:34337717 | DOI:10.26355/eurrev_202107_26380 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: X Chen R Zhang X-Y Tang Source Type: research

Efficacy of suprascapular nerve blocks for management of hemiplegic shoulder pain: a systematic review and meta-analysis
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4702-4713. doi: 10.26355/eurrev_202107_26381.ABSTRACTOBJECTIVE: To compare the efficacy of suprascapular nerve block (SSNB) with other treatment modalities for management of HSP in terms of relieving pain and improving range of motion of shoulder joints.MATERIALS AND METHODS: An electronic search was carried out in PubMed, CENTRAL, SCOPUS and EMBASE databases using a series of relevant keywords, along with a manual search. Randomized clinical trials comparing the efficacy of SSNB with placebo injections, intra-articular injections (IAI), ultrasound and Pulsed RF were identified. T...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: Y-G Wang Y-D Fu N-J Zhou J-K Yang Source Type: research

One gut microbiota, Fusobacterium nucleatum aggravates Neonatal necrotizing enterocolitis by induction of IRF5 expression through lncRNA ENO1-IT1/miR-22-3p axis
CONCLUSIONS: Taken together, these results demonstrate that F. nucleatum is mechanically, biologically and clinically connected to NEC. LncRNA ENO1-IT1 may be important targets for F. nucleatum in NEC-inflammation, and a meaningful in treating patients with Neonatal NEC with elevated F. nucleatum.PMID:34337719 | DOI:10.26355/eurrev_202107_26382 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: J-C Lin X-Y Ma J-Y Liu Y-Z Luo L Lin L-Y Zhang Source Type: research

Meta-analysis of the effects of furosemide combined with hydration therapy on contrast-induced acute kidney injury after coronary intervention
CONCLUSIONS: Furosemide combined with hydration therapy has no significant effect on the incidence of CI-AKI in patients after coronary intervention but can reduce the incidence of MACEs and mortality, thereby providing clinical benefits.PMID:34337720 | DOI:10.26355/eurrev_202107_26383 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: M-J Hu E-F Luo C-C Tang L Wang Q-G Zhang J-B Gong Source Type: research

A novel modification of frozen elephant trunk technique: unique protocol from one institution
CONCLUSIONS: Our modification of FET technique was feasible, effective, and safe, with good postoperative outcomes.PMID:34337721 | DOI:10.26355/eurrev_202107_26384 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: D H S Phung T S Nguyen H-L Vo N T Vu N T Duong V L Pham Q H Doan H U Nguyen Source Type: research

Pathophysiology and management of Akathisia 70 years after the introduction of the chlorpromazine, the first antipsychotic
CONCLUSIONS: Pharmacological management may pose a challenge in chronic akathisia. Rotation between different pharmacological management strategies may be optimal in resistant cases. Discontinuation of the causative drug and use of b-blockers, mirtazapine, benzodiazepines or gabapentinoids for symptomatic relief is the basis of management.PMID:34337722 | DOI:10.26355/eurrev_202101_26386 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: N Zareifopoulos M Katsaraki P Stratos V Villiotou M Skaltsa A Dimitriou M Karveli P Efthimiou M Lagadinou D Velissaris Source Type: research

Potential mechanisms of metformin-induced memory impairment
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4757-4761. doi: 10.26355/eurrev_202107_26387.ABSTRACTMetformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus. In addition to its ability to lower glucose levels, it has recently been reported to be potentially useful for the treatment of other conditions because of its anticancer activity, cardiovascular protective effect, neuroprotective effect, and efficacy in the treatment of polycystic ovary syndrome. However, long-term use of metformin may lead to side-effects such as memory impairment. Here, we critically review the effect of metformin on...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: A Alhowail Source Type: research

PCSK9 and inflammatory biomarkers in the early post kidney transplantation period
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4762-4772. doi: 10.26355/eurrev_202107_26388.ABSTRACTOBJECTIVE: Various biomarkers have been studied in the early post-kidney transplantation (post-KTx) period in order to identify potential therapeutic targets for improving long-term graft survival. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a biomarker that has recently gained interest in cardiovascular disease but its role still remains to be defined post-KTx.PATIENTS AND METHODS: We prospectively evaluated the levels of PCSK9, interleukin (IL)-6, WBC and C-reactive protein in seventy-three hemodialysis patients u...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: C Melexopoulou S Marinaki E Oikonomou M J Bonios P Theofilis A Miliou G Siasos D Tousoulis J N Boletis Source Type: research

Efficacy and effect of intracameral adrenaline infusion on pulse rate and blood pressure during phacoemulsification in patients with dark irides
Eur Rev Med Pharmacol Sci. 2021 Jan;25(14):4773-4778. doi: 10.26355/eurrev_202101_26389.ABSTRACTOBJECTIVE: Phacoemulsification is the most common cataract surgery that needs optimum circumstances in the field of surgery. This comparative pre- and postoperative study assessed the efficacy and safety of using adrenaline in the irrigating solution as an adjunct to preoperative topical mydriatics in dark irides during Phaco surgery.PATIENTS AND METHODS: This was a prospective observational study that enrolled 421 cataract patients (421 eyes) with dark irides, who were scheduled for Phaco surgery from January 2019 to August 202...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: K M Alabdulwahhab Source Type: research

Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial
CONCLUSIONS: Although the perioperative administration of parecoxib did not provide significantly better postoperative pain control or reduce the opioid requirement relative to placebo, its use led to a shorter hospital stay.PMID:34337726 | DOI:10.26355/eurrev_202107_26390 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: C Angthong S Manuwong V Singh P Rajbhandari A Veljkovic Source Type: research

A new and reliable landmark in parotid surgery: tragomastoid groove (Akil Groove)
CONCLUSIONS: The tragomastoid groove was defined for the first time in the literature as a reliable landmark for identifying the facial nerve truncus easily during parotid surgery.PMID:34337727 | DOI:10.26355/eurrev_202107_26391 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: F Akil V Kinis U Yilmaz M Akdag S F Toprak M Ayral H Durak Source Type: research

Endoscopic laser diverticulotomy in Zenker's diverticulum: experiences with basal wound sealing using a collagen-fibrin patch
CONCLUSIONS: These findings suggest that use of a collagen-fibrin sealant patch in endoscopic laser diverticulotomy may contribute to the safety of endoscopic controlled laser diverticulotomy without comprising the success rates.PMID:34337728 | DOI:10.26355/eurrev_202107_26392 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: M Koch V Thimsen M Traxdorf J Zenk H Iro E Treutlein K Mantsopoulos Source Type: research

The relevance of inositols treatment for PCOS before and during ART
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4799-4809. doi: 10.26355/eurrev_202107_26393.ABSTRACTPolycystic ovary syndrome (PCOS) is an endo-crine disorder that occurs in 8-10% of women of reproduc-tive age. It is characterized by oligo or anovulation, hyperandrogenism and/or polycystic ovaries, but also by an increased insulin plasma level especially in overweight/obese women or in those with familial diabetes. In the last years, among the insulin sensitizers, the use of the two active isoforms of inositols (myo-inositol and d-chiro-inositol) has been spreading for the treatment of PCOS insulin resistance. Several studies ...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: P G Artini E Malacarne V Tomatis A D Genazzani Source Type: research

Polypharmacy is a determinant of hospitalization in Parkinson's disease
CONCLUSIONS: Among patients with PD, the number of daily medications is associated with increased risk of hospitalization; an increasing number of drugs is associated with increasing number of hospitalizations.PMID:34337730 | DOI:10.26355/eurrev_202107_26394 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: S Giovannini A Laudisio L Navarini M R Lo Monaco M Ciaburri E Serafini C Loreti D Coraci P Caliandro L Padua R Bernabei L Biscotti G Zuccal à Source Type: research

An automated synthesis of 177Lu-EDTMP as an efficient bone-seeking therapeutic radiopharmaceutical
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4829-4834. doi: 10.26355/eurrev_202107_26396.ABSTRACTOBJECTIVE: Radiolabeled bisphosphonates have found wide clinical use in nuclear medicine for palliative therapy of bone metastases. 177Lu-EDTMP was used to relieve metastatic bone pain in patients with breast or prostate cancer. The therapeutic efficacy of 177Lu-EDTMP at 1-, 3-, 6-, and 8-weeks post-therapy was evaluated using Standard Pain Scoring Assessment Criteria. In addition, toxicity was evaluated in terms of hematological parameters using the Common Terminology Criteria for Adverse Events V4.0.PATIENTS AND METHODS: A ful...
Source: European Review for Medical and Pharmacological Sciences - August 2, 2021 Category: Drugs & Pharmacology Authors: U Elboga B Kilbas E Sahin Y B Cay ırlı K Eryilmaz T Begec H E Bakar G Mercanoglu Y Z Celen Source Type: research