Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers after Acute Kidney Injury: Friend, Foe, or Acquaintance?
PMID: 32074594 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 19, 2020 Category: Urology & Nephrology Authors: Coca SG Tags: Am J Nephrol Source Type: research

Sodium Fate after Sodium Bicarbonate Infusion: Influence of Altered Acid-Base Status.
CONCLUSIONS: This study demonstrates that hypobicarbonatemic animals have a Na+ space that exceeds TBW after an acute infusion of hypertonic NaHCO3 indicating osmotic inactivation of a fraction of retained sodium. In addition to an expanded Na+ space, these animals have a larger HCO3- space compared with hyperbicarbonatemic animals. Both phenomena appear to reflect the wider range of titration of nonbicarbonate buffers (Δ pH) occurring during NaHCO3- loading whenever initial [HCO3-]e is low. The data indicate that the fate of administered bicarbonate drives the internal distribution and the external disposal of sodiu...
Source: American Journal of Nephrology - February 18, 2020 Category: Urology & Nephrology Authors: Adrogué HJ, Awan AA, Madias NE Tags: Am J Nephrol Source Type: research

Glucose Exposure in Peritoneal Dialysis Is a Significant Factor Predicting Peritonitis.
CONCLUSION: A higher exposure to glucose rather than loss of RRF is associated with an increased risk of peritonitis. This confirms the detrimental effects of glycemic harm to the peritoneal host defense on invading microorganisms and argues for the use of the lowest PD glucose concentrations possible. PMID: 32069459 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 18, 2020 Category: Urology & Nephrology Authors: Uiterwijk H, Franssen CFM, Kuipers J, Westerhuis R, Nauta FL Tags: Am J Nephrol Source Type: research

Nephrology Training: Time to Revisit Integrative Physiology.
PMID: 32062651 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 14, 2020 Category: Urology & Nephrology Authors: Bansal S, Kanakia R, Sharma K, Tsai S, Prasad A Tags: Am J Nephrol Source Type: research

Pregnancy-Related Acute Kidney Injury in the United States: Clinical Outcomes and Health Care Utilization.
CONCLUSION: The rates of pregnancy-related AKI hospitalizations have increased during the last decade. Factors associated with a higher likelihood of AKI during pregnancy included older age, black and Native American race/ethnicity, and diabetes. Hospitalizations with pregnancy-related AKI have an increased risk of inpatient mortality and CV events, and a higher health care utilization than do those without AKI. PMID: 32045905 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2020 Category: Urology & Nephrology Authors: Shah S, Meganathan K, Christianson AL, Harrison K, Leonard AC, Thakar CV Tags: Am J Nephrol Source Type: research

Aortic Calcification and Arterial Stiffness Burden in a Chronic Kidney Disease Cohort with High Cardiovascular Risk: Baseline Characteristics of the IMpact of Phosphate Reduction On Vascular End-Points in Chronic Kidney Disease Trial.
In conclusion, IMPROVE-CKD participants had high baseline risk for cardiovascular events, as suggested by high baseline PWV and AAC values. PMID: 32023606 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 5, 2020 Category: Urology & Nephrology Authors: Lioufas NM, Pedagogos E, Hawley CM, Pascoe EM, Elder GJ, Badve SV, Valks A, Toussaint ND, on behalf of the IMPROVE-CKD Investigators Tags: Am J Nephrol Source Type: research

Factors Associated with Elective Withdrawal of Maintenance Hemodialysis: A Case-Control Analysis.
CONCLUSIONS: Important differences separate patients who electively withdraw from those who die of non-withdrawal causes. Worsening disability, in particular, may be a marker for withdrawal. PMID: 32018244 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 4, 2020 Category: Urology & Nephrology Authors: Wetmore JB, Yan H, Gilbertson DT, Liu J Tags: Am J Nephrol Source Type: research

Comparing Patient Survival of Home Hemodialysis and Peritoneal Dialysis Patients.
We examined a national cohort of incident end-stage renal disease patients that was comprised of 1,993 and 16,514 patients transitioning to HHD and PD, respectively, from 2007 to 2011. The HHD patients were matched with PD patients using propensity score (PS). Demographics, comorbidities, duration of dialysis, and body mass index were adjusted for in logistic regression models using PS matching. We matched 1,915 HHD patients with 1,915 PD patients based on the PS. The patients were categorized by their vintage (duration of dialysis) at the time of the transition to HHD or PD (
Source: American Journal of Nephrology - January 28, 2020 Category: Urology & Nephrology Authors: Choi SJ, Obi Y, Ko GJ, You AS, Eriguchi R, Wang M, Rhee CM, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Acute Kidney Injury: To Be or Not to Be: That Is the Question: It's the Company It Keeps.
;a IL PMID: 31991404 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 28, 2020 Category: Urology & Nephrology Authors: Piña IL Tags: Am J Nephrol Source Type: research

Improved Sleep Quality Improves Blood Pressure Control among Patients with Chronic Kidney Disease: A Pilot Study.
Abstract BACKGROUND: Despite the abundance of data documenting the consequences of poor sleep quality on blood pressure (BP), no previous study to our knowledge has addressed the impact of sleep improvement on resistant hypertension among patients with chronic kidney disease (CKD). METHODS: The aim of this pilot study was to determine whether improved sleep quality and duration will improve BP control in patients with resistant hypertension and CKD. It was a prospective single-center cohort study that involved 30 hypertensive subjects with CKD presenting with primary resistant hypertension and poor sleep quality or duration
Source: American Journal of Nephrology - January 24, 2020 Category: Urology & Nephrology Authors: Ali W, Gao G, Bakris GL Tags: Am J Nephrol Source Type: research

Calcium-Alkali Syndrome Associated with Hypoparathyroidism Following Total Thyroidectomy.
This study aimed to investigate the incidence of hypercalcemia, renal impairment, metabolic alkalosis, and CAS in patients treated for presumed hypoparathyroidism after total thyroidectomy. METHODS: Twenty-seven patients with neck cancers who underwent total thyroidectomy without parathyroid autotransplantation between January 2010 and October 2013 at our hospital were consecutively included. All patients received calcium lactate and alfacalcidol for postsurgical hypocalcemia. We defined hypercalcemia as a corrected serum calcium level (cCa) ≥10.5 mg/dL, metabolic alkalosis as a difference in serum sodium and serum...
Source: American Journal of Nephrology - January 22, 2020 Category: Urology & Nephrology Authors: Kuroya S, Yazawa M, Shibagaki Y, Tominaga N Tags: Am J Nephrol Source Type: research

Membranous Nephropathy Due to Anti-GBM Antibodies of Mice and Men.
PMID: 31962308 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2020 Category: Urology & Nephrology Authors: Glassock RJ Tags: Am J Nephrol Source Type: research

Readmissions after Acute Kidney Injury during Left Ventricular Assist Device Implantation Hospitalization.
CONCLUSION: AKI-D was associated with highest -30-day readmission risk, possibly related to negatively synergistic effects of LVAD, kidney dysfunction, and dialysis related factors on infection and GI bleeding risks. AKI alone was not associated with increased readmission risk. PMID: 31962311 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2020 Category: Urology & Nephrology Authors: Walther CP, Winkelmayer WC, Deswal A, Niu J, Navaneethan SD Tags: Am J Nephrol Source Type: research

Management of Presumed Acute Kidney Injury during Hypertensive Therapy: Stay Calm and Carry on?
Abstract BACKGROUND: Recent studies have demonstrated that intensive blood pressure control is associated with improved cardiovascular outcomes. Acute kidney injury (AKI), however, was more common in the intensive treatment group prompting concern in the nephrology community. SUMMARY: Clinical trials on hypertension control have traditionally defined AKI by changes in serum creatinine. However, serum creatinine has several inherent limitations as a marker of kidney injury, with various factors influencing its production, secretion, and elimination. Urinary biomarkers of kidney injury and repair have the poten...
Source: American Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Authors: Chen TK, Parikh CR Tags: Am J Nephrol Source Type: research

APOL1 Genotyping in Potential African American Living Kidney Donors: Utility and Cost-Effectiveness.
CONCLUSION: We propose a role for systematically incorporating APOL1 genotyping in the evaluation and informed consent process of potential AA donors while acknowledging the controversial considerations associated with it. PMID: 31940609 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Authors: Gudsoorkar P, Anand M, Abu Jawdeh BG Tags: Am J Nephrol Source Type: research

Circulating Endocannabinoid Levels as Potential Biomarkers for Mortality in Hemodialysis Patients.
PMID: 31935722 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 14, 2020 Category: Urology & Nephrology Authors: Beberashvili I Tags: Am J Nephrol Source Type: research

Effect of Ultrafiltration on Sleep Apnea and Cardiac Function in End-Stage Renal Disease.
Abstract RATIONALE: End-stage renal disease (ESRD) patients have high annual mortality mainly due to cardiovascular causes. The acute effects of obstructive and central sleep apnea on cardiac function in ESRD patients have not been determined. We therefore tested, in patients with ESRD, the hypotheses that (1) sleep apnea induces deterioration in cardiac function overnight and (2) attenuation of sleep apnea severity by ultrafiltration (UF) attenuates this deterioration. METHODS: At baseline, ESRD patients, on conventional hemodialysis, with left ventricular ejection fraction (LVEF)>45% had polysomnography ...
Source: American Journal of Nephrology - January 14, 2020 Category: Urology & Nephrology Authors: Inami T, Lyons OD, Perger E, Yadollahi A, Floras JS, Chan CT, Bradley TD Tags: Am J Nephrol Source Type: research

Circulating Endocannabinoids and Mortality in Hemodialysis Patients.
CONCLUSIONS: In MHD patients, the circulating levels of ECB ligand, 2-AG, may play an important role in determining body mass and risk of mortality. These observations were unique to 2-AG as similar findings were not obtained with serum AEA. Future studies need to investigate the mechanisms responsible for these associations and examine the modulation of the ECB system as a potential target for therapy in ESRD. PMID: 31935741 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 14, 2020 Category: Urology & Nephrology Authors: Moradi H, Park C, Streja E, Argueta DA, DiPatrizio NV, You AS, Rhee CM, Vaziri ND, Kalantar-Zadeh K, Piomelli D Tags: Am J Nephrol Source Type: research

Epitope Mapping of Human α3(IV)NC1-Induced Membranous Nephropathy in Mice.
CONCLUSION: The linear peptide of α3141-154 could induce clinical and histopathological features of MN in DBA/1 mice, which might give clues to the mechanism of MN in combination with anti-GBM disease. PMID: 31927545 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 10, 2020 Category: Urology & Nephrology Authors: Wang J, Wang M, Cui Z, Zhao MH Tags: Am J Nephrol Source Type: research

Renal Anti-Fibrotic Effect of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension.
Abstract BACKGROUND: Clinical trials have shown that empagliflozin (Empa), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, promotes nephroprotective effects in diabetic patients. The mechanisms underlying nephroprotection are not completely known and it is not known whether the renal beneficial action is present even in non-diabetic kidney disease. The aim of this study was to evaluate the effect of Empa administration on the development of renal fibrosis in an experimental model of angiotensin II (Ang II)-dependent hypertension. METHODS: Sprague Dawley rats (n = 31) were divided into 4 experimental group...
Source: American Journal of Nephrology - January 7, 2020 Category: Urology & Nephrology Authors: Castoldi G, Carletti R, Ippolito S, Colzani M, Barzaghi F, Stella A, Zerbini G, Perseghin G, di Gioia CRT Tags: Am J Nephrol Source Type: research

Erratum.
Authors: PMID: 31910426 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 7, 2020 Category: Urology & Nephrology Tags: Am J Nephrol Source Type: research

Novel Model Predicts Diabetic Nephropathy in Type 2 Diabetes.
CONCLUSION: The novel model was very useful for predicting DN in patients with T2D and kidney disease, and thereby could be used by clinicians either in triage or as a replacement for biopsy. PMID: 31865340 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 19, 2019 Category: Urology & Nephrology Authors: Jiang S, Fang J, Yu T, Liu L, Zou G, Gao H, Zhuo L, Li W Tags: Am J Nephrol Source Type: research

Research Themes and Trends in Ten Top-Ranked Nephrology Journals: A Text Mining Analysis.
CONCLUSION: Stakeholders of nephrology research may use these trends further to develop priorities and enrich the research agenda for the future. PMID: 31838480 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2019 Category: Urology & Nephrology Authors: Zengul FD, Lee T, Delen D, Almehmi A, Ivankova NV, Mehta T, Topuz K Tags: Am J Nephrol Source Type: research

Validation of a Risk Equation Predicting Hemodialysis Arteriovenous Fistula Primary Failure in Elderly.
CONCLUSIONS: When externally applied to a cohort of U.S. older hemodialysis patients, the Lok's risk equation exhibited poor discrimination and calibration accuracy. It is invalid to use it to predict AVF primary failure. A more complex model with strong predictors is expected to better serve clinical determination for AVF placement in this population. PMID: 31822005 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2019 Category: Urology & Nephrology Authors: Qian JZ, McAdams-DeMarco MA, Ng D, Lau B Tags: Am J Nephrol Source Type: research

Utility of Genomic Testing after Renal Biopsy.
CONCLUSIONS: An accurate genetic diagnosis can result in changes in clinical diagnosis, understanding of pathological mechanism, and treatment. NGS should be considered as a complementary diagnostic technique to kidney biopsy in the evaluation of patients with kidney disease. PMID: 31822006 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2019 Category: Urology & Nephrology Authors: Murray SL, Dorman A, Benson KA, Connaughton DM, Stapleton CP, Fennelly NK, Kennedy C, McDonnell CA, Kidd K, Cormican SM, Ryan LA, Lavin P, Little MA, Bleyer AJ, Doyle B, Cavalleri GL, Hildebrandt F, Conlon PJ Tags: Am J Nephrol Source Type: research

Impact of Cardio-Renal-Metabolic Comorbidities on Cardiovascular Outcomes and Mortality in Type 2 Diabetes Mellitus.
CONCLUSION: In T2DM patients, CKD presence was associated with higher risk of modified MACE, HF, and ACM. This may have risk-stratification implications for T2DM patients based on background CKD and highlights the potential importance of novel renoprotective strategies. PMID: 31812955 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 6, 2019 Category: Urology & Nephrology Authors: Cherney DZI, Repetto E, Wheeler DC, Arnold SV, MacLachlan S, Hunt PR, Chen H, Vora J, Kosiborod M Tags: Am J Nephrol Source Type: research

Analysis of Factors Influencing the Prognostic Significance of Hyponatremia in Peritoneal Dialysis Patients.
CONCLUSIONS: Our results suggest that hyponatremia performs as a consistent correlate of the risk of mortality mainly in PD patients manifesting direct or indirect signs of inflammation and wasting, while this association is not apparently linked to the presence of overhydration or nominal, preexisting comorbid conditions. PMID: 31812962 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 6, 2019 Category: Urology & Nephrology Authors: Bravo González-Blas L, García-Gago L, Astudillo-Jarrín D, Rodríguez-Magariños C, López-Iglesias A, García Falcón T, Rodríguez-Carmona A, Pérez Fontán M Tags: Am J Nephrol Source Type: research

Matters of Life and Death: Why Do Older Patients Choose Conservative Management?
CONCLUSION: Patients' decisions to choose CM were influenced by their values and previous experience with dialysis, in addition to comorbidities and limited prognoses. Promoting the choice of CM in the United States will require training of clinicians in primary palliative care competencies, including communication and decision-making skills, as well as basic symptom management proficiencies. PMID: 31775149 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 27, 2019 Category: Urology & Nephrology Authors: Saeed F, Adams H, Epstein RM Tags: Am J Nephrol Source Type: research

Parathyroidectomy Influences Coronary Artery Calcium Score in Asymptomatic Hemodialysis Patients with Secondary Hyperparathyroidism.
This study was performed with institutional review board approval. Written consent was obtained from each patient. Forty-eight patients (mean age ± SD 54.50 ± 13.14 years; range 33-77 years) undergoing maintenance hemodialysis who underwent PTX and 56 patients (mean age 55.28 ± 12.32 years; range 35-76 years) who did not undergo PTX received prospective follow-up for 2 years. CACS was quantitatively performed using the Agatston method after CT scan. The differences between baseline and end-of-study PTX parameters were analyzed with the paired Student t test. RESULTS: For patients who underwen...
Source: American Journal of Nephrology - November 26, 2019 Category: Urology & Nephrology Authors: Ma Q, Su D, Liu F, Xing H, Han X, Ma D Tags: Am J Nephrol Source Type: research

Impact of Serum Bicarbonate Levels on Muscle Mass and Kidney Function in Pre-Dialysis Chronic Kidney Disease Patients.
Abstract BACKGROUND: Treatment of metabolic acidosis to target the higher serum bicarbonate level than guideline recommendation may downregulate muscle protein degradation and improve renal function among chronic kidney disease (CKD) patients. We conducted a study to test the effects of increased serum bicarbonate level on muscle parameters, nutrition, and renal function in pre-dialysis CKD patients. METHODS: This was a randomized, controlled study. CKD stage 3-4 patients with serum HCO3-
Source: American Journal of Nephrology - November 21, 2019 Category: Urology & Nephrology Authors: Kittiskulnam P, Srijaruneruang S, Chulakadabba A, Thokanit NS, Praditpornsilpa K, Tungsanga K, Eiam-Ong S Tags: Am J Nephrol Source Type: research

Increasing Nephrologist Awareness of Symptom Burden in Older Hospitalized End-Stage Renal Disease Patients.
CONCLUSIONS: Our findings reinforce the high symptom burden prevalent in older ESRD patients. The improvement in total scores, and individual symptoms of pain and itching in group 1 indicates better symptom control when physician awareness is increased. Residual symptoms post hospitalization and low utilization of palliative care resources are suggestive of a missed opportunity by nephrologists to address the high symptom burden at the inpatient encounter, which is selective for sick patients and/or indication of inadequacy of dialysis to control these symptoms. PMID: 31743896 [PubMed - as supplied by publisher] (Sour...
Source: American Journal of Nephrology - November 19, 2019 Category: Urology & Nephrology Authors: Jawed A, Moe SM, Moorthi RN, Torke AM, Eadon MT Tags: Am J Nephrol Source Type: research

A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats.
CONCLUSION: FTY720 treatment reduced the expression of inflammatory cytokines and attenuated the activation of NK-κB and STAT3 pathways in Cy/+ Han:SPRD rats. It suggests that FTY720 may serve as a therapeutic agent for clinical autosomal dominant PKD treatment. PMID: 31694015 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 6, 2019 Category: Urology & Nephrology Authors: Li X, Wu M, Chen L, Lu J, Li G, Fu L, Qi N, Lin Y, Sun Z, Wang X, Zhang H, Liu J, Jiang H, Li L, Mei CL, Luo C Tags: Am J Nephrol Source Type: research

Assessment for Assisted Peritoneal Dialysis by Peritoneal Dialysis Nurses: Results of a Cohort Study.
CONCLUSION: Our results showed that the nurse's subjective assessment of the patient's inability to be treated by self-care PD and the patient's disabilities were strongly associated with the utilization of nurse- and family assisted PD. PMID: 31671419 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 31, 2019 Category: Urology & Nephrology Authors: Guillouët S, Boyer A, Lanot A, Ficheux M, Lobbedez T, Béchade C Tags: Am J Nephrol Source Type: research

Impact of Kidney Function on Cardiovascular Risk and Mortality: A Comparison of South Asian and European Cohorts.
CONCLUSIONS: Strong associations between ACR and outcomes in South Asians of predominantly Indian origin, and null associations for eGFRcys and eGFRcreat, suggest that ACR may have greater utility in CVD risk prediction in South Asians. Further work is needed to validate these -findings. PMID: 31665726 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2019 Category: Urology & Nephrology Authors: Eastwood SV, Chaturvedi N, Sattar N, Welsh PI, Hughes AD, Tillin T Tags: Am J Nephrol Source Type: research

Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.
CONCLUSIONS: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. TRIAL REGISTRATION: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049. PMID: 31665733 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2019 Category: Urology & Nephrology Authors: Ruilope LM, Agarwal R, Anker SD, Bakris GL, Filippatos G, Nowack C, Kolkhof P, Joseph A, Mentenich N, Pitt B, FIGARO-DKD study investigators Tags: Am J Nephrol Source Type: research

Ultrafiltration Rate Effects Declines in Residual Kidney Function in Hemodialysis Patients.
Abstract BACKGROUND: High ultrafiltration rate (UFR) has been associated with increased mortality in hemodialysis (HD) patients. However, the impact of UFR on decline of residual kidney function (RKF) has not been elucidated among patients receiving conventional HD. METHODS: We performed a retrospective cohort study of 7,753 patients who initiated conventional HD from 2007 to 2011 and survived the first year of dialysis with baseline UFR and renal urea clearance (KRU) data at baseline and 1 year (5th patient-quarter). The primary exposure was average UFR at the 1st patient-quarter from dialysis initiation (
Source: American Journal of Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Lee Y, Okuda Y, Sy J, Kim SR, Obi Y, Kovesdy CP, Rhee CM, Streja E, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Aldosterone: The Missing Cardiorenal Link.
PMID: 31661688 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 29, 2019 Category: Urology & Nephrology Authors: Williams GH Tags: Am J Nephrol Source Type: research

Efficacy and Safety of Sodium Zirconium Cyclosilicate for Treatment of Hyperkalemia: An 11-Month Open-Label Extension of HARMONIZE.
CONCLUSION: In the HARMONIZE OLE, most patients maintained mean serum K+ within the normokalemic range for ≤11 months during ongoing SZC treatment. PMID: 31658466 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 28, 2019 Category: Urology & Nephrology Authors: Roger SD, Spinowitz BS, Lerma EV, Singh B, Packham DK, Al-Shurbaji A, Kosiborod M Tags: Am J Nephrol Source Type: research

Percutaneous Coronary Intervention Does Not Lower Cardiovascular Outcomes in Patients with Chronic Kidney Disease.
This study investigates the impact of moderate-CKD on patients undergoing PCI in the current era. METHODS: Patient level data were pooled from 2 multicenter randomized trials (BIONICS and NIREUS trials) with a near "all-comers" design, comparing PCI with ridaforolimus-eluting stents vs. zotarolimus-eluting stents in patients with CAD. Patients were classified according to the presence or absence of moderate-CKD, defined as creatinine clearance (CrCl)
Source: American Journal of Nephrology - October 25, 2019 Category: Urology & Nephrology Authors: Chernin G, Chen S, Ozan O, Liu M, Haberman D, Perlman G, Ben-Yehuda O, Jonas M Tags: Am J Nephrol Source Type: research

Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
CONCLUSIONS: Ser interfered with albumin internalization through the caveolae into GEnCs and podocytes and reduced albuminuria. Dynamin inhibitors may serve as a novel therapeutic option for reducing albuminuria in glomerulonephritis. PMID: 31655808 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2019 Category: Urology & Nephrology Authors: Moriyama T, Karasawa K, Hasegawa F, Uchida K, Nitta K Tags: Am J Nephrol Source Type: research

Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial.
tudy investigators Abstract BACKGROUND: Among diabetics, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality, and progression of their underlying disease. Finerenone is a novel, non-steroidal, selective mineralocorticoid-receptor antagonist which has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD), while revealing only a low risk of hyperkalemia. However, the effect of finerenone on renal and CV outcomes has not been investigated in long-term trials yet. METHODS: The Finerenone in Reducing Kidney Failure an...
Source: American Journal of Nephrology - October 25, 2019 Category: Urology & Nephrology Authors: Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Nowack C, Kolkhof P, Ferreira AC, Schloemer P, Filippatos G, on behalf of the FIDELIO-DKD study investigators Tags: Am J Nephrol Source Type: research

Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.
In this study, we aim to determine whether venous intimal hyperplasia in hemodialysis (HD) vascular access is influenced by common polymorphisms in the DDAH1 genes. METHODS: This is a prospective observational cohort study. A total of 473 HD patients referred for the angioplasty of vascular access were enrolled. There were 190 arteriovenous grafts (AVG) and 283 arteriovenous fistulas (AVF). The follow-up lasted for 2 years after the interventions. Seven single nucleotide polymorphisms (SNPs) in DDAH1 were genotyped and ADMA were measured at baseline. The primary outcome was restenosis after angioplasty. RESULTS: ...
Source: American Journal of Nephrology - October 22, 2019 Category: Urology & Nephrology Authors: Wu CC, Hsieh MY, Lee CK, Chuang SY, Chung MY, Lin CC Tags: Am J Nephrol Source Type: research

Cardiac Troponin T and Right Ventricular Systolic Pressure Predict Cardiovascular and Mortality Risk in Kidney Transplant Candidates.
CONCLUSION: Elevated cTnT and RVSP were independently predictive of CV events and mortality in the cohort. Clinicians should consider the value of RVSP and cTnT as markers of CV risk in KTx evaluation. PMID: 31639809 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2019 Category: Urology & Nephrology Authors: Firth C, Kaur T, Chakkera H, Zhang N, Shamoun F, Steidley E, Heilman R, Keddis M, Lerma E Tags: Am J Nephrol Source Type: research

Disparate Chronic Kidney Disease-Associated Outcomes in South Asians Ethnicity or Estimated Glomerular Filtration Rate?
PMID: 31639812 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2019 Category: Urology & Nephrology Authors: Modi GK, Jha V Tags: Am J Nephrol Source Type: research

Rationale and Strategies for Preserving Residual Kidney Function in Dialysis Patients.
Abstract BACKGROUND: Residual kidney function (RKF) conveys a survival benefit among dialysis patients, but the mechanism remains unclear. Improved volume control, clearance of protein-bound and middle molecules, reduced inflammation and preserved erythropoietin and vitamin D production are among the proposed mechanisms. Preservation of RKF requires techniques to measure it accurately to be able to uncover factors that accelerate its loss and interventions that preserve it and ultimately to individualize therapy. The average of renal creatinine and urea clearance provides a superior estimate of RKF in dialysis pat...
Source: American Journal of Nephrology - October 18, 2019 Category: Urology & Nephrology Authors: Li T, Wilcox CS, Lipkowitz MS, Gordon-Cappitelli J, Dragoi S Tags: Am J Nephrol Source Type: research

Rapid Progression of Autosomal Dominant Polycystic Kidney Disease: Urinary Biomarkers as Predictors.
CONCLUSION: Measurement of urinary β2MG and MCP-1 excretion allows selection of ADPKD patients with rapidly progressive disease, with a predictive value comparable to or even higher than that of TKV or PKD mutation. Easy and inexpensive to measure urinary markers therefore hold promise to help predict prognosis in ADPKD. PMID: 31600749 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: Messchendorp AL, Meijer E, Visser FW, Engels GE, Kappert P, Losekoot M, Peters DJM, Gansevoort RT, on behalf of the DIPAK-1 study investigators Tags: Am J Nephrol Source Type: research

Predictors of Care Gaps in Home Dialysis: The Home Dialysis Virtual Ward Study.
CONCLUSION: The HDVW was effective at identifying several potential care gaps, and patients were satisfied across several domains of care. This intervention may be valuable in supporting home dialysis patients during care transitions. PMID: 31600760 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 10, 2019 Category: Urology & Nephrology Authors: Nadeau-Fredette AC, Chan CT, Bargman JM, Copland MA, Finkle SN, Oliver MJ, Pauly RP, Perl J, Shah NA, Zimmerman DL, Tennankore KK Tags: Am J Nephrol Source Type: research

Sequential Therapy for Remission Induction in Severe Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis.
CONCLUSION: ST with GC and CYC followed by RTX is effective for in AAV patients with severe renal disease. Therapy-related adverse events are comparable to other studies, and further modification in ST with decrease in GC dosage should be explored. PMID: 31593967 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 8, 2019 Category: Urology & Nephrology Authors: Kant S, Habbach A, Gapud EJ, Manno RL, Gattu R, Seo P, Geetha D Tags: Am J Nephrol Source Type: research

Kidney Injury Biomarkers with Clinical Utility: Has Godot Finally Arrived?
PMID: 31553978 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2019 Category: Urology & Nephrology Authors: Coca SG Tags: Am J Nephrol Source Type: research

Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.
CONCLUSIONS: Among HIV+ men, higher urine albumin and α1m are associated with subsequent declines in kidney function, independent of eGFR. PMID: 31553981 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2019 Category: Urology & Nephrology Authors: Ascher SB, Scherzer R, Estrella MM, Shlipak MG, Ng DK, Palella FJ, Witt MD, Ho K, Bennett MR, Parikh CR, Ix JH, Jotwani V Tags: Am J Nephrol Source Type: research