Diagnostic yield of exome sequencing in early onset hypertensive nephropathy in adults
CONCLUSIONS: The high diagnostic yield of ES (15%) in a population of patients thought to have HN casts further doubts on the validity of the existing diagnosis criteria, including histological criteria, supposed to characterize the condition. This was especially true in patients with no African ancestry where ES positivity reached 30%.PMID:38471460 | DOI:10.1159/000538173 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 12, 2024 Category: Urology & Nephrology Authors: Justine Serre Alice Doreille Laure Raymond Gaspard Suc Micka ël Bobot Marine Dancer C édric Rafat Laurent Mesnard Source Type: research

Association of Proton Pump Inhibitor Use and Immune Checkpoint Inhibitor Mediated Acute Kidney Injury: A Meta-Analysis and a Review of Related Outcomes
CONCLUSION: This meta-analysis highlights the importance of cautious PPI prescription in cancer patients undergoing ICI therapy. Clinicians are advised to evaluate the risks and benefits of PPI use and consider alternative therapies when feasible.PMID:38471492 | DOI:10.1159/000538274 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 12, 2024 Category: Urology & Nephrology Authors: Arjunmohan Mohan Pajaree Krisanapan Supawit Tangpanithandee Charat Thongprayoon Swetha Rani Kanduri Wisit Cheungpasitporn Sandra M Herrmann Source Type: research

Diagnostic yield of exome sequencing in early onset hypertensive nephropathy in adults
CONCLUSIONS: The high diagnostic yield of ES (15%) in a population of patients thought to have HN casts further doubts on the validity of the existing diagnosis criteria, including histological criteria, supposed to characterize the condition. This was especially true in patients with no African ancestry where ES positivity reached 30%.PMID:38471460 | DOI:10.1159/000538173 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 12, 2024 Category: Urology & Nephrology Authors: Justine Serre Alice Doreille Laure Raymond Gaspard Suc Micka ël Bobot Marine Dancer C édric Rafat Laurent Mesnard Source Type: research

Association of Proton Pump Inhibitor Use and Immune Checkpoint Inhibitor Mediated Acute Kidney Injury: A Meta-Analysis and a Review of Related Outcomes
CONCLUSION: This meta-analysis highlights the importance of cautious PPI prescription in cancer patients undergoing ICI therapy. Clinicians are advised to evaluate the risks and benefits of PPI use and consider alternative therapies when feasible.PMID:38471492 | DOI:10.1159/000538274 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 12, 2024 Category: Urology & Nephrology Authors: Arjunmohan Mohan Pajaree Krisanapan Supawit Tangpanithandee Charat Thongprayoon Swetha Rani Kanduri Wisit Cheungpasitporn Sandra M Herrmann Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research

Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research

Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research

Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research