Cardiovascular Benefits of a Diet Enriched in Fruits and Vegetables
Am J Nephrol 2019;49:435 –437 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Neurology Source Type: research

Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate
Conclusion: Metabolic acidosis improvement and eGFR preservation were comparable in CKD patients treated with F + V or oral NaHCO3 but F + V better improved CVD risk indicators, making it a potentially better treatment option for reducing CVD risk.Am J Nephrol 2019;49:438 –448 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Neurology Source Type: research

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury
Conclusions: Most patients with moderate to severe AKI are unaware of their condition, lack understanding of risk factors for recurrent AKI, and desire more information. Patient-centered communication to optimize awareness, understanding, and care will require coordinated educational strategies throughout the continuum of AKI care.Am J Nephrol 2019;49:449 –459 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Neurology Source Type: research

Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort
Conclusions: Severe ci + ct and cg at biopsy were predictors of unfavorable allograft prognosis in TG patients even after taking into consideration clinical characteristics. Histologic severity of cg and g + ptc was significantly associated with clinical proteinuria.Am J Nephrol 2019;49:425 –434 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Neurology Source Type: research

Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate.
Abstract BACKGROUND: Current guidelines recommend treatment of metabolic acidosis in chronic kidney disease (CKD) with sodium-based alkali. We tested the hypothesis that treatment with base-producing fruits and vegetables (F + V) better improves cardiovascular disease (CVD) risk indicators than oral sodium bicarbonate (NaHCO3). METHODS: We randomized 108 macroalbuminuric, matched, nondiabetic CKD patients with metabolic acidosis to F + V (n = 36) in amounts to reduce dietary acid by half, oral NaHCO3 (HCO3, n = 36) 0.3 mEq/kg bw/day, or to Usual Care (UC, n = 36) to assess the 5-year effect of these intervent...
Source: American Journal of Nephrology - April 17, 2019 Category: Urology & Nephrology Authors: Goraya N, Munoz-Maldonado Y, Simoni J, Wesson DE Tags: Am J Nephrol Source Type: research

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury.
CONCLUSIONS: Most patients with moderate to severe AKI are unaware of their condition, lack understanding of risk factors for recurrent AKI, and desire more information. Patient-centered communication to optimize awareness, understanding, and care will require coordinated educational strategies throughout the continuum of AKI care. PMID: 30995659 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Urology & Nephrology Authors: Siew ED, Parr SK, Wild MG, Levea SL, Mehta KG, Umeukeje EM, Silver SA, Ikizler TA, Cavanaugh KL Tags: Am J Nephrol Source Type: research

Cardiovascular Benefits of a Diet Enriched in Fruits and Vegetables.
PMID: 30995660 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2019 Category: Urology & Nephrology Authors: Palmer BF, Clegg DJ Tags: Am J Nephrol Source Type: research

Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort.
Abstract BACKGROUND: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS: A single-center retrospective cohort with biopsy-proven TG was investigated. Renal biopsies were scored according to Banff 2017. The primary outcome was death-censored graft failure defined as return to dialysis or estimated glomerular filtration rate (eGFR) decreased to
Source: American Journal of Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: Li X, Chen J, Cheng D, Wang W, Xie K, Zhang M, Xu F, Wen J, Tang Z Tags: Am J Nephrol Source Type: research

Open-Label Clinical Trials of Oral Pulse Dexamethasone for Adults with Idiopathic Nephrotic Syndrome
Conclusion: We conclude that high dose oral dexamethasone is well tolerated by adults with idiopathic nephrotic syndrome and may have some efficacy.Am J Nephrol 2019;49:377 –385 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease
Conclusions: Underserved CKD Mexican women have a high rate of adverse maternal-fetal outcomes during pregnancy. The risk may be higher in patients needing dialysis during pregnancy, many of whom remained dialysis dependent after delivery.Am J Nephrol 2019;49:386 –396 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

Failure in Physiologic Flexibility: Adverse Pregnancy Outcomes in Women with Reduced Renal Reserve
Am J Nephrol 2019;49:397 –399 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study
Conclusions: In a cohort of #x3e; 1,300 women with varied kidney disorders, increased adverse obstetric and perinatal events were observed, and the nature and magnitude of risk differed according to diagnosis. In particular, vesicoureteric reflux is not a benign condition in pregnancy. Women with nonchronic conditions still had increased risk of preterm birth. We confirm that women with kidney disorders warrant vigilant and tailored prepregnancy care and clinical care in pregnancy.Am J Nephrol 2019;49:400 –409 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

Treating Systemic Klotho Deficiency
Am J Nephrol 2019;49:410 –412 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

Therapeutic Challenge of Minicircle Vector Encoding Klotho in Animal Model
Conclusion: Together, these findings implied that self-generated Klotho protein, using MC technology, is functionally active and relevant as a therapeutic approach in renal injury.Am J Nephrol 2019;49:413 –423 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2019 Category: Neurology Source Type: research

Therapeutic Challenge of Minicircle Vector Encoding Klotho in Animal Model.
CONCLUSION: Together, these findings implied that self-generated Klotho protein, using MC technology, is functionally active and relevant as a therapeutic approach in renal injury. PMID: 30982029 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 12, 2019 Category: Urology & Nephrology Authors: Shin YJ, Luo K, Quan Y, Ko EJ, Chung BH, Lim SW, Yang CW Tags: Am J Nephrol Source Type: research

Treating Systemic Klotho Deficiency.
PMID: 30982040 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 12, 2019 Category: Urology & Nephrology Authors: Pastor J, Moe OW Tags: Am J Nephrol Source Type: research

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study.
This study examined the prevalence and outcomes of varied kidney disorders using population-level perinatal data from a large cohort. METHODS: Women with singleton pregnancies> 20 weeks' gestation from the South Australian Pregnancy Outcomes Unit (1990-2012). Women with a kidney disorders diagnostic code were grouped into categories (immunological, cystic/genetic, urological, vesicoureteral reflux (VUR), pyelonephritis and "other"). Key pregnancy outcomes were assessed, with adjustment for demographic variables. RESULTS: Kidney disorders were reported in 1,392 (0.3%) of 407,580 births. These pregnanc...
Source: American Journal of Nephrology - April 12, 2019 Category: Urology & Nephrology Authors: Fitzpatrick A, Venugopal K, Scheil W, McDonald SP, Jesudason S Tags: Am J Nephrol Source Type: research

Failure in Physiologic Flexibility: Adverse Pregnancy Outcomes in Women with Reduced Renal Reserve.
PMID: 30982043 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 12, 2019 Category: Urology & Nephrology Authors: Lemoine E, Karumanchi SA Tags: Am J Nephrol Source Type: research

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.
CONCLUSIONS: Underserved CKD Mexican women have a high rate of adverse maternal-fetal outcomes during pregnancy. The risk may be higher in patients needing dialysis during pregnancy, many of whom remained dialysis dependent after delivery. PMID: 30982046 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 12, 2019 Category: Urology & Nephrology Authors: Ibarra-Hernandez M, Alcantar-Vallin ML, Soto-Cruz A, Jimenez-Alvarado PM, Villa-Villagran F, Diaz-Avila JJ, Tamez-Hernandez F, Leon-Barrios M, Chatrenet A, Piccoli GB, Garcia-Garcia G Tags: Am J Nephrol Source Type: research

Open-Label Clinical Trials of Oral Pulse Dexamethasone for Adults with Idiopathic Nephrotic Syndrome.
CONCLUSION: We conclude that high dose oral dexamethasone is well tolerated by adults with idiopathic nephrotic syndrome and may have some efficacy. PMID: 30965344 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 9, 2019 Category: Urology & Nephrology Authors: Cho ME, Branton MH, Smith DA, Bartlett L, Howard L, Reynolds JC, Rosenstein D, Sethi S, Nava MB, Barisoni L, Fervenza FC, Kopp JB Tags: Am J Nephrol Source Type: research

Extracting Meaning of Tubular Injury Molecules: Implications for Cardiorenal Health
Am J Nephrol 2019;49:343 –345 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2019 Category: Neurology Source Type: research

Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease
Conclusions: Among hypertensive trial participants with CKD, higher urinary IL-18 and YKL-40 were associated with higher risk of mortality, but not CVD.Am J Nephrol 2019;49:346 –355 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2019 Category: Neurology Source Type: research

Blood Pressure Control, Acute Kidney Injury, and Cardiovascular Events: Separating the Chaff from the Wheat
Am J Nephrol 2019;49:356 –358 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2019 Category: Neurology Source Type: research

Association of Acute Kidney Injury with Cardiovascular Events and Death in Systolic Blood Pressure Intervention Trial
Conclusions: Among older adults with hypertension at high cardiovascular risk, intensive treatment of blood pressure independently increased risk of AKI, which substantially raised risks of major cardiovascular events and death.Am J Nephrol 2019;49:359 –367 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2019 Category: Neurology Source Type: research

Modeled Daily Ingested, Absorbed and Bound Phosphorus: New Measures of Mineral Balance in Hemodialysis Patients
Conclusions: The combination of urea kinetic and phosphorus modeling can be used to estimate measures related to phosphorus intake. High DIP/PCR or DIP/kg body weight values in anuric patients suggest consumption of a diet high in phosphorus additives or noncompliance with the prescribed amount of phosphorus binders.Am J Nephrol 2019;49:368 –376 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2019 Category: Neurology Source Type: research

Modeled Daily Ingested, Absorbed and Bound Phosphorus: New Measures of Mineral Balance in Hemodialysis Patients.
Abstract BACKGROUND: Control of predialysis serum phosphorus in hemodialysis patients is challenging. We explored the utility of a novel kinetic phosphorus modeling program. METHODS: As part of a quality assurance program, urea kinetic modeling results were combined with those from phosphorus kinetic modeling to compute modeled daily ingested phosphorus (DIP) and components making up this metric, including absorbed, bound, and nonabsorbed, nonbound phosphorus. RESULTS: In 182 hemodialysis patients, DIP averaged 1,089 ± 348 mg/day in men and 934 ± 292 in women (p
Source: American Journal of Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Kapoian T, Khalil S, O'Mara NB, Brink DM, Daugirdas JT Tags: Am J Nephrol Source Type: research

Extracting Meaning of Tubular Injury Molecules: Implications for Cardiorenal Health.
PMID: 30939471 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Rossignol P, Ferreira JP Tags: Am J Nephrol Source Type: research

Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease.
arch Group Abstract BACKGROUND: Kidney tubulointerstitial fibrosis on biopsy is a strong predictor of chronic kidney disease (CKD) progression, and CKD is associated with elevated risk of cardiovascular disease (CVD). Tubular health is poorly quantified by traditional kidney function measures, including estimated glomerular filtration rate (eGFR) and albuminuria. We hypothesized that urinary biomarkers of tubular injury, inflammation, and repair would be associated with higher risk of CVD and mortality in persons with CKD. METHODS: We measured urinary concentrations of interleukin-18 (IL-18), kidney inju...
Source: American Journal of Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Jotwani VK, Lee AK, Estrella MM, Katz R, Garimella PS, Malhotra R, Rifkin DE, Ambrosius W, Freedman BI, Cheung AK, Raphael KL, Drawz P, Neyra JA, Oparil S, Punzi H, Shlipak MG, Ix JH, for the SPRINT Research Group Tags: Am J Nephrol Source Type: research

Blood Pressure Control, Acute Kidney Injury, and Cardiovascular Events: Separating the Chaff from the Wheat.
PMID: 30939475 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Thomas G, Schold JD Tags: Am J Nephrol Source Type: research

Association of Acute Kidney Injury with Cardiovascular Events and Death in Systolic Blood Pressure Intervention Trial.
Abstract RATIONALE AND OBJECTIVE: In the Systolic Blood Pressure Intervention Trial, the possible relationships between acute kidney injury (AKI) and risk of major cardiovascular events and death are not known. STUDY DESIGN: Post hoc analysis of a multicenter, randomized, controlled, open-label clinical trial. SETTING AND PARTICIPANTS: Hypertensive adults without diabetes who were ≥50 years of age with prior cardiovascular disease, chronic kidney disease (CKD), 10-year Framingham risk score> 15%, or age> 75 years were assigned to a systolic blood pressure target of
Source: American Journal of Nephrology - April 2, 2019 Category: Urology & Nephrology Authors: Dieter BP, Daratha KB, McPherson SM, Short R, Alicic RZ, Tuttle KR Tags: Am J Nephrol Source Type: research

Systolic Blood Pressure Intervention Trial and Statins, a Story of Statistical Interaction
Am J Nephrol 2019;49:294 –296 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Modifying Effect of Statins on Fatal Outcomes in Chronic Kidney Disease Patients in the Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis
Conclusion: The combination of statin therapy and intensive SBP management leads to improved survival in hypertensive patients with CKD.Am J Nephrol 2019;49:297 –306 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy
Conclusion: We identified and demonstrated that GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by negatively  regulating C1GALT1 expression. We believe that this finding will provide theoretical foundations for a new mechanism of Gd-IgA1 production in IgAN patients.Am J Nephrol 2019;49:307 –316 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients
Conclusions: Comparing both measurements, 24 h-PWV is an independent predictor for all-cause-mortality in hemodialysis patients beyond Office-PWV.Am J Nephrol 2019;49:317 –327 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Renal Angiotensinogen and Sodium-Glucose Cotransporter-2 Inhibition: Insights from Experimental Diabetic Kidney Disease
Am J Nephrol 2019;49:328 –330 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Canagliflozin Prevents Intrarenal Angiotensinogen Augmentation and Mitigates Kidney Injury and Hypertension in Mouse Model of Type 2 Diabetes Mellitus
Conclusions: CANA prevents intrarenal AGT upregulation and oxidative stress and which may mitigate high blood pressure, renal tubular fibrosis, and renal inflammation in T2DM.Am J Nephrol 2019;49:331 –341 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 31, 2019 Category: Neurology Source Type: research

Renal Angiotensinogen and Sodium-Glucose Cotransporter-2 Inhibition: Insights from Experimental Diabetic Kidney Disease.
PMID: 30921790 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 28, 2019 Category: Urology & Nephrology Authors: Burns KD, Cherney D Tags: Am J Nephrol Source Type: research

Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy.
CONCLUSION: We identified and demonstrated that GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by negatively regulating C1GALT1 expression. We believe that this finding will provide theoretical foundations for a new mechanism of Gd-IgA1 production in IgAN patients. PMID: 30917363 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 27, 2019 Category: Urology & Nephrology Authors: Wang C, Ye M, Zhao Q, Xia M, Liu D, He L, Chen G, Peng Y, Liu H Tags: Am J Nephrol Source Type: research

Modifying Effect of Statins on Fatal Outcomes in Chronic Kidney Disease Patients in the Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis.
Abstract BACKGROUND: Management of chronic kidney disease (CKD) patients includes efforts directed toward modifying traditional cardiovascular risk factors. Such efforts include optimal management of hypertension together with the initiation of statin therapy. METHODS: In this observational study, we determine the modifying effect of statins on the relationship of systolic blood pressure (SBP) goal with mortality and other outcomes in patients with CKD participating in a clinical trial. At baseline, 2,646 CKD patients (estimated glomerular filtration rate
Source: American Journal of Nephrology - March 27, 2019 Category: Urology & Nephrology Authors: Rivera M, Tamariz L, Suarez M, Contreras G Tags: Am J Nephrol Source Type: research

Systolic Blood Pressure Intervention Trial and Statins, a Story of Statistical Interaction.
PMID: 30917365 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 27, 2019 Category: Urology & Nephrology Authors: Tu W, Agarwal R Tags: Am J Nephrol Source Type: research

Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients.
CONCLUSIONS: Comparing both measurements, 24 h-PWV is an independent predictor for all-cause-mortality in hemodialysis patients beyond Office-PWV. PMID: 30917369 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 27, 2019 Category: Urology & Nephrology Authors: Matschkal J, Mayer CC, Sarafidis PA, Lorenz G, Braunisch MC, Guenthner R, Angermann S, Steubl D, Kemmner S, Bachmann Q, Hauser C, Nerl L, Baumann M, Mann JF, Moog P, Kuechle C, Renders L, Heemann U, Wassertheurer S, Schmaderer C Tags: Am J Nephrol Source Type: research

Aiming Too Low: Reevaluation of Target Concentrations of Serum 25-Hydroxyvitamin D in Secondary Hyperparathyroidism
Am J Nephrol 2019;49:281 –283 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 15, 2019 Category: Neurology Source Type: research

Rationale for Raising Current Clinical Practice Guideline Target for Serum 25-Hydroxyvitamin D in Chronic Kidney Disease
Conclusion: ERC therapy produced exposure-dependent reductions in plasma iPTH and bone turnover markers only when mean serum total 25-hydroxyvitamin D reached at least 50.8 ng/mL, indicating that current targets for vitamin D repletion therapy in CKD are too low. Gradual elevation of mean serum 25-hydroxyvitamin D to 92.5 ng/mL was not associated with significant adverse changes in safety parameters.Am J Nephrol 2019;49:284 –293 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 15, 2019 Category: Neurology Source Type: research

Rationale for Raising Current Clinical Practice Guideline Target for Serum 25-Hydroxyvitamin D in Chronic Kidney Disease.
CONCLUSION: ERC therapy produced exposure-dependent reductions in plasma iPTH and bone turnover markers only when mean serum total 25-hydroxyvitamin D reached at least 50.8 ng/mL, indicating that current targets for vitamin D repletion therapy in CKD are too low. Gradual elevation of mean serum 25-hydroxyvitamin D to 92.5 ng/mL was not associated with significant adverse changes in safety parameters. PMID: 30878999 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 15, 2019 Category: Urology & Nephrology Authors: Strugnell SA, Sprague SM, Ashfaq A, Petkovich M, Bishop CW Tags: Am J Nephrol Source Type: research

Aiming Too Low: Reevaluation of Target Concentrations of Serum 25-Hydroxyvitamin D in Secondary Hyperparathyroidism.
PMID: 30879016 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 15, 2019 Category: Urology & Nephrology Authors: Berg AH, Thadhani RI Tags: Am J Nephrol Source Type: research

Long-Term Efficacy and Safety of Molidustat for Anemia in Chronic Kidney Disease: DIALOGUE Extension Studies
Conclusions: Molidustat was well tolerated for up to 36 months and appears to be an effective alternative to darbepoetin and epoetin in the long-term management of anemia associated with CKD.Am J Nephrol 2019;49:271 –280 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 8, 2019 Category: Neurology Source Type: research

Long-Term Efficacy and Safety of Molidustat for Anemia in Chronic Kidney Disease: DIALOGUE Extension Studies.
CONCLUSIONS: Molidustat was well tolerated for up to 36 months and appears to be an effective alternative to darbepoetin and epoetin in the long-term management of anemia associated with CKD. PMID: 30852574 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 8, 2019 Category: Urology & Nephrology Authors: Akizawa T, Macdougall IC, Berns JS, Bernhardt T, Staedtler G, Taguchi M, Iekushi K, Krueger T Tags: Am J Nephrol Source Type: research

Adherence to Kidney Disease: Improving Global Outcomes Mineral and Bone Guidelines for Monitoring Biochemical Parameters
Conclusions: In fee-for-service Medicare beneficiaries, laboratory testing for CKD-MBD biochemical markers appears to be suboptimal in relation to KDIGO guidelines. Competing priories, such as management of comorbid disease and preparation for renal replacement therapy, may distract from CKD-MBD monitoring.Am J Nephrol 2019;49:225 –232 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2019 Category: Neurology Source Type: research

Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History
Conclusion: Detection ofPKD1/PKD2 mutation, especiallyPKD1 truncating, is useful for predicting the renal outcome and rate of TKV increase in PKD patients with no apparent family history.Am J Nephrol 2019;49:233 –240 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2019 Category: Neurology Source Type: research

Fibroblast Growth Factor 23 Trajectories in Chronic Hemodialysis Patients: Lessons from the HEMO Study
Conclusions: We identified 5 distinct FGF23 trajectories over 24 months among HEMO study participants including a decreasing trajectory. The low stable FGF23 trajectory was associated with a reduced HR of all-cause mortality.Am J Nephrol 2019;49:263 –270 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2019 Category: Neurology Source Type: research