NET Formation in Dialysis: A Valuable, albeit Mysterious and Enticing Predictor of Mortality
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2020 Category: Neurology Source Type: research

Elevated Circulating Cell-Free DNA in Hemodialysis-Treated Patients Is Associated with Increased Mortality
Conclusions: Post-HD cfDNA level was superior to standard blood tests and could serve as a biomarker to assist in decision-making for HD-treated patients.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2020 Category: Neurology Source Type: research

Relationship between Serum Uric Acid and Mortality Risk in Hemodialysis Patients: A Multicenter Prospective Cohort Study
Conclusion: There was a U-shaped relationship between SUA levels and the risk of all-cause mortality, CVD mortality, and non-CVD mortality in MHD patients.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 16, 2020 Category: Neurology Source Type: research

Relationship between Serum Uric Acid and Mortality Risk in Hemodialysis Patients: A Multicenter Prospective Cohort Study.
Abstract BACKGROUND: Several studies have reported that low serum uric acid (SUA) levels are related to increased risk of mortality in maintenance hemodialysis (MHD) patients. However, the possible detrimental effects of high SUA on the mortality risk have not been well examined. Moreover, the possible effect modifiers for the SUA-mortality association have not been fully investigated. To address the aforementioned gap, we aimed to explore the nonlinear relationship between SUA levels and all-cause and cardiovascular disease (CVD) mortality risk, and to examine any possible effect modifiers in MHD patients. M...
Source: American Journal of Nephrology - October 16, 2020 Category: Urology & Nephrology Authors: Yang Y, Qin X, Li Y, Yang S, Chen J, He Y, Huang Y, Lin Z, Li Y, Kong Y, Lu Y, Zhao Y, Wan Q, Wang Q, Huang S, Liu Y, Liu A, Liu F, Hou FF, Liang M Tags: Am J Nephrol Source Type: research

Acute Kidney Injury in COVID-19: Another Challenge for Nephrology
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 15, 2020 Category: Neurology Source Type: research

Acute Kidney Injury in COVID-19: Another Challenge for Nephrology.
PMID: 33059350 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 15, 2020 Category: Urology & Nephrology Authors: Rudnick MR, Hilburg R Tags: Am J Nephrol Source Type: research

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes
Conclusion: Known risk factors provide moderate discrimination of rapid eGFR decline. Identification of blood and urine biomarkers associated with rapid eGFR decline in T1D using targeted omics strategies may provide insight into disease mechanisms and improve upon clinical predictive models using traditional risk factors.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 14, 2020 Category: Neurology Source Type: research

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes.
Abstract BACKGROUND: Individuals with type 1 diabetes (T1D) demonstrate varied trajectories of estimated glomerular filtration rate (eGFR) decline. The molecular pathways underlying rapid eGFR decline in T1D are poorly understood, and individual-level risk of rapid eGFR decline is difficult to predict. METHODS: We designed a case-control study with multiple exposure measurements nested within 4 well-characterized T1D cohorts (FinnDiane, Steno, EDC, and CACTI) to identify biomarkers associated with rapid eGFR decline. Here, we report the rationale for and design of these studies as well as results of models te...
Source: American Journal of Nephrology - October 14, 2020 Category: Urology & Nephrology Authors: Limonte CP, Valo E, Montemayor D, Afshinnia F, Ahluwalia TS, Costacou T, Darshi M, Forsblom C, Hoofnagle AN, Groop PH, Miller RG, Orchard TJ, Pennathur S, Rossing P, Sandholm N, Snell-Bergeon JK, Ye H, Zhang J, Natarajan L, de Boer IH, Sharma K Tags: Am J Nephrol Source Type: research

Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications
Conclusion: AKI in our hospitalized COVID-19 patients was common and carried a high mortality, especially in patients with AKI stage 3. RRT did not improve survival. Policy changes and planning for this high incidence of AKI in COVID-19 patients and its associated high mortality are necessary at the local and national levels.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 2, 2020 Category: Neurology Source Type: research

Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications.
In this study, we report our unique experience with AKI in COVID-19 patients in a low socioeconomic and predominantly ethnic minority group and provide its incidence, risk factors, and prognosis to expand the current understanding of this complication. METHODS: In this single-center, retrospective cohort study, we analyzed the data of 469 COVID-19 patients admitted to the Brookdale University Hospital in Brooklyn, NY, from March 18 through April 23, 2020. Information regarding demographics, comorbidities, medications, clinical and laboratory data, and outcomes was collected from the electronic medical records. Both un...
Source: American Journal of Nephrology - October 1, 2020 Category: Urology & Nephrology Authors: Zahid U, Ramachandran P, Spitalewitz S, Alasadi L, Chakraborti A, Azhar M, Mikhalina G, Sherazi A, Narh JT, Khattar P, Bedi P Tags: Am J Nephrol Source Type: research

Characteristics and Graft Survival of Kidney Transplant Recipients with Renal Cell Carcinoma
Conclusion: In our experience, RCC had a detrimental impact on graft survival among KTRs, highlighting the potential benefit of early diagnosis and optimal immunosuppression management in optimizing graft survival.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2020 Category: Neurology Source Type: research

Characteristics and Graft Survival of Kidney Transplant Recipients with Renal Cell Carcinoma.
Abstract BACKGROUND: The incidence of renal cell carcinoma (RCC) is higher in kidney transplant recipients (KTRs) compared to the general population. However, the risk factors and outcomes based on the diagnosis of RCC after kidney transplantation are limited. METHODS: We analyzed risk factors for the development of RCC in KTRs transplanted at our institution between 1994 and 2016. We compared the incidence of graft failure and mortality in KTRs with RCC to matched controls using 5:1 event density sampling. Identifying the risk factors of RCC and patient and graft survival were outcomes of interest. RESU...
Source: American Journal of Nephrology - September 29, 2020 Category: Urology & Nephrology Authors: Machhi R, Mandelbrot DA, Al-Qaoud T, Astor BC, Parajuli S Tags: Am J Nephrol Source Type: research

Real World Use and Effects of Calcimimetics in Treating Mineral and Bone Disorder in Hemodialysis Patients
Conclusion: Both calcimimetics were effective in keeping PTH, Ca, and Phos levels within target. Patients receiving etelcalcetide tended to have lower laboratory values for PTH, Ca, and Phos over time, while patients receiving cinacalcet tended to be more likely to be in target for Ca over time.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 23, 2020 Category: Neurology Source Type: research

Exenatide and Renal Outcomes in Patients with Type 2 Diabetes and Diabetic Kidney Disease
Conclusion: Exenatide plus insulin glargine treatment for 24 weeks resulted in a reduction of albuminuria in T2DM patients with DKD.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 23, 2020 Category: Neurology Source Type: research

Exenatide and Renal Outcomes in Patients with Type 2 Diabetes and Diabetic Kidney Disease.
CONCLUSION: Exenatide plus insulin glargine treatment for 24 weeks resulted in a reduction of albuminuria in T2DM patients with DKD. PMID: 32966971 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 22, 2020 Category: Urology & Nephrology Authors: Wang X, Zhang H, Zhang Q, Guan M, Sheng S, Mo W, Zou M, Li J, Bi J, Tang X, Zeng H, He J, Xu G, Li P, Xue Y Tags: Am J Nephrol Source Type: research

Real World Use and Effects of Calcimimetics in Treating Mineral and Bone Disorder in Hemodialysis Patients.
CONCLUSION: Both calcimimetics were effective in keeping PTH, Ca, and Phos levels within target. Patients receiving etelcalcetide tended to have lower laboratory values for PTH, Ca, and Phos over time, while patients receiving cinacalcet tended to be more likely to be in target for Ca over time. PMID: 32966995 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 22, 2020 Category: Urology & Nephrology Authors: Danese MD, Lubeck D, Belozeroff V, Lin TC, Desai P, Gleeson M, Martin K, Chonchol M Tags: Am J Nephrol Source Type: research

Genotype-Guided Hydralazine Therapy
Background: Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a condition frequently managed by nephrologists and other clinicians. Hydralazine hydrochloride undergoes metabolism by the N-acetyltransferase 2 (NAT2) enzyme. NAT2 is highly polymorphic as approximately 50% of the general population are slow acetylators. In this review, we first evaluate the link between NAT2 genotype and phenotype. We then assess the evidence available for genotype-guided therapy of hydralazine, specifically addressing associations of NAT2 acetylator status with hydralazi...
Source: American Journal of Nephrology - September 14, 2020 Category: Neurology Source Type: research

Genotype-Guided Hydralazine Therapy.
Abstract BACKGROUND: Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a condition frequently managed by nephrologists and other clinicians. Hydralazine hydrochloride undergoes metabolism by the N-acetyltransferase 2 (NAT2) enzyme. NAT2 is highly polymorphic as approximately 50% of the general population are slow acetylators. In this review, we first evaluate the link between NAT2 genotype and phenotype. We then assess the evidence available for genotype-guided therapy of hydralazine, specifically addressing associations of NAT2 acetylator sta...
Source: American Journal of Nephrology - September 13, 2020 Category: Urology & Nephrology Authors: Collins KS, Raviele ALJ, Elchynski AL, Woodcock AM, Zhao Y, Cooper-DeHoff RM, Eadon MT Tags: Am J Nephrol Source Type: research

Cortical Bone Microarchitecture in Dialysis Patients
Conclusions: 3D- µCT is a reliable method for the measurement of cortical bone in bone biopsies. Prospective studies are awaited to address its value in discriminating fracture risk.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 10, 2020 Category: Neurology Source Type: research

Cortical Bone Microarchitecture in Dialysis Patients.
lal M Abstract BACKGROUND: The incidence of skeletal fractures is high in dialysis patients. Current available tools are insufficient to predict bone fragility. We analyzed the microarchitecture in patients on dialysis therapy using bone biopsies and peripheral microcomputed tomography. METHODS: We analyzed 12 trans-iliac bone biopsies of patients with recent fractures. Bone microarchitecture was assessed in the bone cores by histology (2D-), microcomputed tomography (3D-µCT), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia. RESULTS: Trabecular bone volume/tis...
Source: American Journal of Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Benillouche E, Ostertag A, Marty C, Ureña Torres P, Cohen-Solal M Tags: Am J Nephrol Source Type: research

Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants
Conclusions: Among trial participants with hypertension and CKD, baseline measures of tubular function were associated with subsequent declines in kidney function, although these associations were diminished by intensive blood pressure control.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 9, 2020 Category: Neurology Source Type: research

Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants.
Abstract BACKGROUND: Kidney tubular atrophy on biopsy is a strong predictor of chronic kidney disease (CKD) progression, but tubular health is poorly quantified by traditional measures including estimated glomerular filtration rate (eGFR) and albuminuria. We hypothesized that urinary biomarkers of impaired tubule function would be associated with faster eGFR declines in persons with CKD. METHODS: We measured baseline urine concentrations of uromodulin, β2-microglobulin (β2m), and α1-microglobulin (α1m) among 2,428 participants of the Systolic Blood Pressure Intervention Trial with an eGFR
Source: American Journal of Nephrology - September 8, 2020 Category: Urology & Nephrology Authors: Jotwani V, Garimella PS, Katz R, Malhotra R, Bates J, Cheung AK, Chonchol M, Drawz PE, Freedman BI, Haley WE, Killeen AA, Punzi H, Sarnak MJ, Segal MS, Shlipak MG, Ix JH, SPRINT Research Group Tags: Am J Nephrol Source Type: research

APOL1, Acidity, and ATP: Affecting Mitochondrial Function
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2020 Category: Neurology Source Type: research

APOL1, Acidity, and ATP: Affecting Mitochondrial Function.
PMID: 32882695 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 2, 2020 Category: Urology & Nephrology Authors: Kopp JB Tags: Am J Nephrol Source Type: research

Publisher's Note
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 1, 2020 Category: Neurology Source Type: research

An Acidic Environment Induces < b > < i > APOL1 < /i > < /b > -Associated Mitochondrial Fragmentation
Conclusion: Acidic pH facilitates early mitochondrial dysfunction induced byAPOL1 G1 and G2 KRVs in HEK293 cells. We propose that the acidic kidney interstitium may play a role inAPOL1-mediated mitochondrial pathophysiology and nephropathy.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 31, 2020 Category: Neurology Source Type: research

An Acidic Environment Induces APOL1-Associated Mitochondrial Fragmentation.
Abstract BACKGROUND: Apolipoprotein L1 gene (APOL1) G1 and G2 kidney-risk variants (KRVs) cause CKD in African Americans, inducing mitochondrial dysfunction. Modifying factors are required, because a minority of individuals with APOL1 high-risk genotypes develop nephropathy. Given that APOL1 function is pH-sensitive and the pH of the kidney interstitium is
Source: American Journal of Nephrology - August 30, 2020 Category: Urology & Nephrology Authors: Li D, Snipes JA, Murea M, Molina AJA, Divers J, Freedman BI, Ma L, Petrovic S Tags: Am J Nephrol Source Type: research

Podocyte Involvement in Renal Thrombotic Microangiopathy: A Clinicopathological Study
Conclusion: The podocyte injury was prevalent and the FPW levels were closely associated with clinicopathological features, especially prognosis, in renal TMA patients.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 28, 2020 Category: Neurology Source Type: research

Podocyte Involvement in Renal Thrombotic Microangiopathy: A Clinicopathological Study.
CONCLUSION: The podocyte injury was prevalent and the FPW levels were closely associated with clinicopathological features, especially prognosis, in renal TMA patients. PMID: 32862175 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 27, 2020 Category: Urology & Nephrology Authors: Hu YF, Tan Y, Yu XJ, Wang H, Wang SX, Yu F, Zhao MH Tags: Am J Nephrol Source Type: research

AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3
Conclusions: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 27, 2020 Category: Neurology Source Type: research

AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
CONCLUSIONS: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD. PMID: 32854097 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2020 Category: Urology & Nephrology Authors: Liebisch M, Wolf G Tags: Am J Nephrol Source Type: research

Use of a Supportive Kidney Care Video Decision Aid in Older Patients: A Randomized Controlled Trial
Conclusions: Among older patients with advanced CKD, we did not detect a significant difference between an educational verbal script and a video decision aid in improving knowledge of supportive kidney care or preferences. However, patients who received video education reported high satisfaction and acceptability ratings. Future research will determine the effectiveness of a supportive kidney care video decision aid on real-world patient outcomes.Trial Registration: NCT02698722 (ClinicalTrials.gov).Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 13, 2020 Category: Neurology Source Type: research

Use of a Supportive Kidney Care Video Decision Aid in Older Patients: A Randomized Controlled Trial.
Abstract BACKGROUND: There are few studies of patient-facing decision aids that include supportive kidney care as an option. We tested the efficacy of a video decision aid on knowledge of supportive kidney care among older patients with advanced CKD. METHODS: Participants (age ≥ 65 years with advanced CKD) were randomized to receive verbal or video education. Primary outcome was knowledge of supportive kidney care (score range 0-3). Secondary outcomes included preference for supportive kidney care, and satisfaction and acceptability of the video. RESULTS: Among all participants (n = 100), knowledge of...
Source: American Journal of Nephrology - August 12, 2020 Category: Urology & Nephrology Authors: Eneanya ND, Percy SG, Stallings TL, Wang W, Steele DJR, Germain MJ, Schell JO, Paasche-Orlow MK, Volandes AE Tags: Am J Nephrol Source Type: research

Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease
Conclusion: Patients with ADPKD and noPKD1/2 mutation showed less improvement in ΔeGFR/y and the annual rate of increase in TKV with tolvaptan. DetectingPKD1/2 mutations may be useful for predicting the effectiveness of tolvaptan.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 12, 2020 Category: Neurology Source Type: research

Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease.
CONCLUSION: Patients with ADPKD and no PKD1/2 mutation showed less improvement in ΔeGFR/y and the annual rate of increase in TKV with tolvaptan. Detecting PKD1/2 mutations may be useful for predicting the effectiveness of tolvaptan. PMID: 32784291 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 11, 2020 Category: Urology & Nephrology Authors: Sekine A, Hoshino J, Fujimaru T, Suwabe T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y Tags: Am J Nephrol Source Type: research

Mobility Impairment in Patients New to Dialysis
Conclusions: In our cohort of incident dialysis patients, overall gait speed is very low and 54.2% of the subjects continue to lose gait speed over 2 years. Older age, lower handgrip strength, and quality of life are risk factors for slowness. Patients at highest risk of poor gait speed can be identified at dialysis initiation to allow targeted implementation of therapeutic options.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 11, 2020 Category: Neurology Source Type: research

Mobility Impairment in Patients New to Dialysis.
CONCLUSIONS: In our cohort of incident dialysis patients, overall gait speed is very low and 54.2% of the subjects continue to lose gait speed over 2 years. Older age, lower handgrip strength, and quality of life are risk factors for slowness. Patients at highest risk of poor gait speed can be identified at dialysis initiation to allow targeted implementation of therapeutic options. PMID: 32781443 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 10, 2020 Category: Urology & Nephrology Authors: Moorthi RN, Fadel WF, Cranor A, Hindi J, Avin KG, Lane KA, Thadhani RI, Moe SM Tags: Am J Nephrol Source Type: research

Mortality Risk in Chronic Kidney Disease Patients Transitioning to Dialysis: Impact of Opiate and Non-Opiate Use
Conclusions: In NDD-CKD patients transitioning to dialysis, pre-ESRD opiate and gabapentin/pregabalin use were associated with higher post-ESRD mortality, whereas non-opiate analgesic use was not associated with death. There was a graded association between increasing frequency of pre-ESRD opiate use and incrementally higher mortality.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 10, 2020 Category: Neurology Source Type: research

Cardiovascular Determinants of Mortality in Advanced Chronic Kidney Disease
Conclusion: Stress ergometry performance, abdominal aortic calcification score,E/e′ of echocardiography, and plasma cardiac biomarkers and albumin predict mortality in advanced CKD.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 10, 2020 Category: Neurology Source Type: research

Mortality Risk in Chronic Kidney Disease Patients Transitioning to Dialysis: Impact of Opiate and Non-Opiate Use.
CONCLUSIONS: In NDD-CKD patients transitioning to dialysis, pre-ESRD opiate and gabapentin/pregabalin use were associated with higher post-ESRD mortality, whereas non-opiate analgesic use was not associated with death. There was a graded association between increasing frequency of pre-ESRD opiate use and incrementally higher mortality. PMID: 32777779 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 9, 2020 Category: Urology & Nephrology Authors: You AS, Kalantar-Zadeh K, Streja E, Park C, Sim JJ, Tantisattamo E, Hsiung JT, Obi Y, Potukuchi PK, Amin AN, Nguyen DV, Kovesdy CP, Rhee CM Tags: Am J Nephrol Source Type: research

Cardiovascular Determinants of Mortality in Advanced Chronic Kidney Disease.
CONCLUSION: Stress ergometry performance, abdominal aortic calcification score, E/e' of echocardiography, and plasma cardiac biomarkers and albumin predict mortality in advanced CKD. PMID: 32777781 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 9, 2020 Category: Urology & Nephrology Authors: Lankinen R, Hakamäki M, Metsärinne K, Koivuviita NS, Pärkkä JP, Hellman T, Kartiosuo N, Raitakari OT, Järvisalo MJ Tags: Am J Nephrol Source Type: research

Changes in Quality of Life in Older Hemodialysis Patients: A Cohort Study on Dialysis Outcomes and Practice Patterns
Conclusions: Physical QOL became worse as dialysis vintage lengthened. In contrast, mental QOL declined over time within a relatively short period among older maintenance hemodialysis patients.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 31, 2020 Category: Neurology Source Type: research

Changes in Quality of Life in Older Hemodialysis Patients: A Cohort Study on Dialysis Outcomes and Practice Patterns.
This study aimed to describe the health-related QOL and its change in older maintenance hemodialysis patients and to demonstrate characteristics associated with health-related QOL. METHODS: Data on 892 maintenance hemodialysis patients aged 60 years or older who were surveyed using the Kidney Disease Quality of Life Short Form at baseline and 2 years after study enrollment in phases 4 (2009-2011) and 5 (2012-2014) of the Japanese Dialysis Outcomes and Practice Patterns Study were analyzed. We categorized participants into 3 age groups (60-69, 70-79, and ≥80 years) and described baseline physical component summary (...
Source: American Journal of Nephrology - July 30, 2020 Category: Urology & Nephrology Authors: Ishiwatari A, Yamamoto S, Fukuma S, Hasegawa T, Wakai S, Nangaku M Tags: Am J Nephrol Source Type: research

COVID-19 in Hospitalized Patients on Chronic Peritoneal Dialysis: A Case Series
Conclusion: Hospitalized patients on PD with COVID-19 had a relatively mild course, and majority of them were discharged home.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 30, 2020 Category: Neurology Source Type: research

COVID-19 in Hospitalized Patients on Chronic Peritoneal Dialysis: A Case Series.
CONCLUSION: Hospitalized patients on PD with COVID-19 had a relatively mild course, and majority of them were discharged home. PMID: 32731215 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 29, 2020 Category: Urology & Nephrology Authors: Sachdeva M, Uppal NN, Hirsch JS, Ng JH, Malieckal D, Fishbane S, Jhaveri KD, Northwell COVID-19 Research Consortium and the Northwell Nephrology COVID-19 Research Consortium Tags: Am J Nephrol Source Type: research

Increased Incident Ischemic Stroke Risk in Advanced Kidney Disease: A Large-Scale Real-World Data Study
Conclusion: Although we found that OAC use was effective and recommended for patients with AF, advanced kidney disease is still an independent risk factor for IS/SE, even in patients taking OAC. Physicians should be aware of this risk and strictly control modifiable risk factors, regardless of OAC use.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 29, 2020 Category: Neurology Source Type: research

Increased Incident Ischemic Stroke Risk in Advanced Kidney Disease: A Large-Scale Real-World Data Study.
CONCLUSION: Although we found that OAC use was effective and recommended for patients with AF, advanced kidney disease is still an independent risk factor for IS/SE, even in patients taking OAC. Physicians should be aware of this risk and strictly control modifiable risk factors, regardless of OAC use. PMID: 32726780 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 28, 2020 Category: Urology & Nephrology Authors: Maeda T, Nishi T, Funakoshi S, Tada K, Tsuji M, Satoh A, Kawazoe M, Yoshimura C, Arima H Tags: Am J Nephrol Source Type: research

Nephrology Provider Surprise Question Response and Hospitalizations in Older Adults with Advanced CKD
Conclusion: Nephrology providers ’ responses to the surprise question for older patients with advanced NDD-CKD were independently associated with proportion of future time spent hospitalized and time to first hospitalization. Additional studies should examine how to use this information to provide patients with anticipatory guida nce on their possible clinical trajectory and to target potentially preventable hospitalizations.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 28, 2020 Category: Neurology Source Type: research

Obesity: An Independent Predictor of Morbidity and Graft Loss after Kidney Transplantation
Conclusion: In the current era of renal transplant care, obesity is common, and high BMI remains associated with significant medical and surgical complications after transplant.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 28, 2020 Category: Neurology Source Type: research

Obesity: An Independent Predictor of Morbidity and Graft Loss after Kidney Transplantation.
CONCLUSION: In the current era of renal transplant care, obesity is common, and high BMI remains associated with significant medical and surgical complications after transplant. PMID: 32721967 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 27, 2020 Category: Urology & Nephrology Authors: Aziz F, Ramadorai A, Parajuli S, Garg N, Mohamed M, Mandelbrot DA, Foley DP, Garren M, Djamali A Tags: Am J Nephrol Source Type: research