Acknowledgement to the Reviewers
Am J Nephrol 2018;48:482 –484 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2018 Category: Neurology Source Type: research

Contents Vol. 48, 2018
Am J Nephrol 2018;48:I –VI (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2018 Category: Neurology Source Type: research

Increased Mortality Associated with Higher Pre-Dialysis Serum Sodium Variability: Results of the International MONitoring Dialysis Outcome Initiative
Conclusion: Higher SNa variability associated with increased all-cause mortality at all levels of SNa. DR of SNa showed the strongest association with mortality and may constitute a Simple and novel prognostic indicator, easily applicable at the bedside.Am J Nephrol 2019;49:1 –10 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2018 Category: Neurology Source Type: research

Gender Disparities in Vascular Access Surgical Outcomes in Elderly Hemodialysis Patients
Conclusions: While AVFs should be considered the preferred vascular access in most circumstances, clinical AVF surgical outcomes are uniformly worse in females. Clinicians should also consider AVGs as a viable alternative in elderly female patients initiating hemodialysis with a CVC to avoid extended CVC dependence.Am J Nephrol 2019;49:11 –19 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2018 Category: Neurology Source Type: research

Trends in Opioid Prescribing Among Hemodialysis Patients, 2007 –2014
Conclusion: Opioid prescribing among HD patients declined between 2012 and 2014. However, HD patients continue receiving substantially more opioids than the general US population.Am J Nephrol 2019;49:20 –31 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2018 Category: Neurology Source Type: research

Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We are Not There Yet
Am J Nephrol 2018;48:434 –437 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Antibodies against M-Type Phospholipase A2 Receptor May Predict Treatment Response and Outcome in Membranous Nephropathy
Conclusion: We documented correlations between anti-PLA2R antibody levels and clinical severity in this large Chinese pMN cohort. Antibody positivity and higher antibody level might predict treatment responses and kidney outcomes of pMN.Am J Nephrol 2018;48:438 –446 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Identifying High-Risk Individuals for Chronic Kidney Disease: Results of the CHERISH Community Demonstration Project
Conclusions: Using targeted selection criteria and simple clinical measures, CHERISH successfully identified a population with a high CKD prevalence and with poor control of CKD risk factors. CHERISH may prove helpful to state and local programs in implementing CKD detection programs in their communities.Am J Nephrol 2018;48:447 –455 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Itraconazole Attenuates Peritoneal Fibrosis Through Its Effect on the Sonic Hedgehog Signaling Pathway in Mice
Conclusion: Our study provides the first evidence that the SHH signaling pathway may be implicated in peritoneal fibrosis. It also demonstrates that itraconazole treatment has protective effects on peritoneal fibrosis through the regulation of the SHH signaling pathway. These findings suggest that blockage of the SHH signaling pathway is a potential therapeutic strategy for peritoneal fibrosis.Am J Nephrol 2018;48:456 –464 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Predictors of Renal Outcomes in Sclerotic Class Anti-Neutrophil Cytoplasmic Antibody Glomerulonephritis
Conclusions: Renal recovery is rare among sclerotic ANCA GN patients requiring dialysis at entry and 12% of patients died in the first year. Entry GFR and tubular atrophy were significant predictors of GFR at 12 months and renal survival in patients with sclerotic class ANCA GN.Am J Nephrol 2018;48:465 –471 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Trends in the Causes of Death among Kidney Transplant Recipients in the United States (1996 –2014)
Conclusions: Despite the downtrend in mortality over the last 2 decades, a significant percentage of KTRs die in 10-years with a functioning graft, and cardiovascular mortality remains the leading cause of death. These data also highlight the need for diligent collection of mortality data in KTRs.Am J Nephrol 2018;48:472 –481 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Neurology Source Type: research

Predictors of Renal Outcomes in Sclerotic Class Anti-Neutrophil Cytoplasmic Antibody Glomerulonephritis.
CONCLUSIONS: Renal recovery is rare among sclerotic ANCA GN patients requiring dialysis at entry and 12% of patients died in the first year. Entry GFR and tubular atrophy were significant predictors of GFR at 12 months and renal survival in patients with sclerotic class ANCA GN. PMID: 30472700 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Menez S, Hruskova Z, Scott J, Cormican S, Chen M, Salama AD, Alasfar S, Little MA, Safrankova H, Honsova E, Tesar V, Geetha D Tags: Am J Nephrol Source Type: research

Trends in the Causes of Death among Kidney Transplant Recipients in the United States (1996-2014).
CONCLUSIONS: Despite the downtrend in mortality over the last 2 decades, a significant percentage of KTRs die in 10-years with a functioning graft, and cardiovascular mortality remains the leading cause of death. These data also highlight the need for diligent collection of mortality data in KTRs. PMID: 30472701 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Awan AA, Niu J, Pan JS, Erickson KF, Mandayam S, Winkelmayer WC, Navaneethan SD, Ramanathan V Tags: Am J Nephrol Source Type: research

Itraconazole Attenuates Peritoneal Fibrosis Through Its Effect on the Sonic Hedgehog Signaling Pathway in Mice.
In this study, we used a mouse model to investigate whether the SHH signaling pathway is involved in the development of peritoneal fibrosis and the effects of itraconazole on peritoneal fibrosis. METHODS: Peritoneal fibrosis was induced by intraperitoneal (IP) injection of 0.1% chlorhexidine gluconate (CG) solution every other day for 4 weeks, with or without itraconazole treatment (20 mg/kg, IP injection on a daily basis). Male C57BL/6 mice were divided into 4 groups: saline group, saline plus itraconazole group, CG group, and CG plus itraconazole group. Isotonic saline was administered intraperitoneally to the contr...
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Kim JS, Cho KS, Park SH, Lee SH, Lee JH, Jeong KH, Lee TW Tags: Am J Nephrol Source Type: research

Identifying High-Risk Individuals for Chronic Kidney Disease: Results of the CHERISH Community Demonstration Project.
Abstract BACKGROUND: Most people with chronic kidney disease (CKD) are not aware of their condition. OBJECTIVES: To assess screening criteria in identifying a population with or at high risk for CKD and to determine their level of control of CKD risk factors. METHOD: CKD Health Evaluation Risk Information Sharing (CHERISH), a demonstration project of the Centers for Disease Control and Prevention, hosted screenings at 2 community locations in each of 4 states. People with diabetes, hypertension, or aged ≥50 years were eligible to participate. In addition to CKD, screening included testing and measures...
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Burrows NR, Vassalotti JA, Saydah SH, Stewart R, Gannon M, Chen SC, Li S, Pederson S, Collins AJ, Williams DE Tags: Am J Nephrol Source Type: research

Antibodies against M-Type Phospholipase A2 Receptor May Predict Treatment Response and Outcome in Membranous Nephropathy.
Abstract BACKGROUND: Anti-phospholipase A2 receptor (PLA2R) antibodies are specific to the diagnosis of primary membranous nephropathy (pMN). The prevalence of positive antibodies varies among different cohorts. Still there is discrepancy in regard to the association between antibody levels and clinical courses, and the prognostic value of antibodies to treatment responses and kidney outcomes. METHODS: Three hundred fifty-nine consecutive kidney biopsy-proven pMN patients were enrolled. Anti-PLA2R antibodies were detected by immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA). RE...
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Qu Z, Zhang MF, Cui Z, Wang J, Wang M, Zhang YM, Wang F, Wang X, Meng LQ, Cheng XY, Liu G, Zhao MH Tags: Am J Nephrol Source Type: research

Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We are Not There Yet.
PMID: 30472711 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 23, 2018 Category: Urology & Nephrology Authors: Wetzels JFM Tags: Am J Nephrol Source Type: research

Genome-Scale Single Nucleotide Resolution Analysis of DNA Methylation in Human Autosomal Dominant Polycystic Kidney Disease
Conclusion: This genome-scale single nucleotide resolution analysis of DNA methylation in human polycystic kidneys suggests that DNA methylation differences at specific loci are associated with ADPKD. Further exploration into the significance of these preliminary results may shed light on the disease process, and potentially reveal new therapeutic possibilities.Am J Nephrol 2018;48:415 –424 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2018 Category: Neurology Source Type: research

Impact of Assisted Peritoneal Dialysis Modality on Outcomes: A Cohort Study of the French Language Peritoneal Dialysis Registry
Conclusions: In assisted PD, technique survival was not associated with PD modality. Nurse-assisted patients had a lower risk of transfer to HD than family assisted patients. Peritonitis risk was not influenced either by PD modality, or by type of assistance. Both APD and CAPD should be offered to assisted-PD patients.Am J Nephrol 2018;48:425 –433 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2018 Category: Neurology Source Type: research

Genome-Scale Single Nucleotide Resolution Analysis of DNA Methylation in Human Autosomal Dominant Polycystic Kidney Disease.
CONCLUSION: This genome-scale single nucleotide resolution analysis of DNA methylation in human polycystic kidneys suggests that DNA methylation differences at specific loci are associated with ADPKD. Further exploration into the significance of these preliminary results may shed light on the disease process, and potentially reveal new therapeutic possibilities. PMID: 30463078 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2018 Category: Urology & Nephrology Authors: Bowden SA, Rodger EJ, Bates M, Chatterjee A, Eccles MR, Stayner C Tags: Am J Nephrol Source Type: research

Impact of Assisted Peritoneal Dialysis Modality on Outcomes: A Cohort Study of the French Language Peritoneal Dialysis Registry.
CONCLUSIONS: In assisted PD, technique survival was not associated with PD modality. Nurse-assisted patients had a lower risk of transfer to HD than family assisted patients. Peritonitis risk was not influenced either by PD modality, or by type of assistance. Both APD and CAPD should be offered to assisted-PD patients. PMID: 30463079 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2018 Category: Urology & Nephrology Authors: Guilloteau S, Lobbedez T, Guillouët S, Verger C, Ficheux M, Lanot A, Béchade C Tags: Am J Nephrol Source Type: research

Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes
Conclusion: After adjustment, patients with rhabdomyolysis were not at an increased risk of HTN compared to patients without rhabdomyolysis. eGFR was paradoxically higher in patients with rhabdomyolysis. There was no association found between rhabdomyolysis and mortality.Am J Nephrol 2018;48:399 –405 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 14, 2018 Category: Neurology Source Type: research

Association of Abdominal Adiposity with Cardiovascular Mortality in Incident Hemodialysis
Conclusions: WHR is significantly associated with CVD mortality including SCD, independently of other CVD risk factors in incident hemodialysis. This simple, easily obtained bedside metric may be useful in dialysis patients for CVD risk stratification.Am J Nephrol 2018;48:406 –414 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 14, 2018 Category: Neurology Source Type: research

Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes.
Abstract BACKGROUND: Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011. METHODS: Information on age, sex, injury severity score, mechanism of injury, serum creatinine, burn injury, ...
Source: American Journal of Nephrology - November 14, 2018 Category: Urology & Nephrology Authors: Faulk T, Walker LE, Howard JT, Janak JC, Sosnov JA, Stewart IJ Tags: Am J Nephrol Source Type: research

Association of Abdominal Adiposity with Cardiovascular Mortality in Incident Hemodialysis.
Abstract BACKGROUND: The risk of cardiovascular mortality is high among adults with end-stage renal disease (ESRD) undergoing hemodialysis. Waist-to-hip ratio (WHR), a metric of abdominal adiposity, is a predictor of cardiovascular disease (CVD) and mortality in the general population; however, no studies have examined the association with CVD mortality, particularly sudden cardiac death (SCD), in incident hemodialysis. METHODS: Among 379 participants incident (
Source: American Journal of Nephrology - November 14, 2018 Category: Urology & Nephrology Authors: Fitzpatrick J, Sozio SM, Jaar BG, McAdams-DeMarco MA, Estrella MM, Tereshchenko LG, Monroy-Trujillo JM, Parekh RS Tags: Am J Nephrol Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells
Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in  HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin or regul...
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis
Conclusions: Peritoneal dialysis is not associated with less CAC or CAC progression than hemodialysis, and perhaps with even more progression. This indicates that vascular calcification does not develop less in peritoneal dialysis than in hemodialysis.Am J Nephrol 2018;48:369 –377 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

Intradialytic Hypotension: Is Midodrine the Answer?
Am J Nephrol 2018;48:378 –380 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension
Conclusion: Although residual confounding may have influenced the results, the associations observed here are not consistent with a potent beneficial effect of midodrine with respect to either clinical or hemodynamic outcomes.Am J Nephrol 2018;48:381 –388 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

No Survival Benefit in Octogenarians and Nonagenarians with Extended Hemodialysis Treatment Time
Conclusion: Extended HD was not associated with lower mortality among octogenarians and nonagenarians, while it was associated with better survival among younger patients. Further studies are needed to determine the optimal treatment session length in elderly incident HD patients.Am J Nephrol 2018;48:389 –398 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis.
CONCLUSIONS: Peritoneal dialysis is not associated with less CAC or CAC progression than hemodialysis, and perhaps with even more progression. This indicates that vascular calcification does not develop less in peritoneal dialysis than in hemodialysis. PMID: 30423550 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Jansz TT, van Reekum FE, Özyilmaz A, de Jong PA, Boereboom FTJ, Hoekstra T, Verhaar MC, van Jaarsveld BC Tags: Am J Nephrol Source Type: research

The Impact of Midodrine on Outcomes in Patients with Intradialytic Hypotension.
CONCLUSION: Although residual confounding may have influenced the results, the associations observed here are not consistent with a potent beneficial effect of midodrine with respect to either clinical or hemodynamic outcomes. PMID: 30423552 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Brunelli SM, Cohen DE, Marlowe G, Van Wyck D Tags: Am J Nephrol Source Type: research

Intradialytic Hypotension: Is Midodrine the Answer?
PMID: 30423560 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Hammes M, Bakris GL Tags: Am J Nephrol Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.
Abstract Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by r...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Liu J, Zhu W, Jiang CM, Feng Y, Xia YY, Zhang QY, Xu PF, Zhang M Tags: Am J Nephrol Source Type: research

No Survival Benefit in Octogenarians and Nonagenarians with Extended Hemodialysis Treatment Time.
Abstract BACKGROUND: The population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not yet clear how treatment session length affects mortality risk in octogenarians and nonagenarians. METHODS: In a cohort of 112,026 incident HD patients between 2007 and 2011, we examined the association of treatment session length with all-cause mortality, adjusting for demographics and comorbid conditions. We also used restricted spline functions f...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Ko GJ, Obi Y, Soohoo M, Chang TI, Choi SJ, Kovesdy CP, Streja E, Rhee CM, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial
Conclusion: L-carnitine supplementation increased calcium and phosphate plasma concentrations with no detected downregulation effect on PTH and FGF23. (Clinical Trial 00322322, May 5, 2006).Am J Nephrol 2018;48:349 –356 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 8, 2018 Category: Neurology Source Type: research

Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial.
te; D Abstract BACKGROUND: The use of L-carnitine has been proposed in haemodialysis (HD) when deficiency is present to improve anaemia resistant to erythropoietin stimulating agent, intradialytic hypotension or cardiac failure. We tested the effects of L-carnitine supplementation on parameters of chronic kidney disease-mineral bone disorder. METHODS: CARNIDIAL was a randomized, double-blinded trial having included 92 incident HD subjects for a 1-year period to receive L-carnitine versus placebo. Determinant factors of C-terminal fibroblast growth factor 23 (cFGF23) and intact FGF23 were studied including Klo...
Source: American Journal of Nephrology - November 8, 2018 Category: Urology & Nephrology Authors: Mercadal L, Tezenas du Montcel S, Chonchol MB, Debure A, Depreneuf H, Servais A, Bassilios N, Assogba U, Allouache M, Prié D Tags: Am J Nephrol Source Type: research

Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate
Conclusion: Increased levels of UA may play an important role in the renal alterations induced by heat stress and continuous episodes of rhabdomyolysis. Therefore, treatments aimed to reduce hyperuricemia may help to decrease the renal burden in these conditions. Clinical trials are suggested to test whether this is also true in humans.Am J Nephrol 2018;48:339 –348 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 2, 2018 Category: Neurology Source Type: research

Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.
CONCLUSION: Increased levels of UA may play an important role in the renal alterations induced by heat stress and continuous episodes of rhabdomyolysis. Therefore, treatments aimed to reduce hyperuricemia may help to decrease the renal burden in these conditions. Clinical trials are suggested to test whether this is also true in humans. PMID: 30391956 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 2, 2018 Category: Urology & Nephrology Authors: Sánchez-Lozada LG, García-Arroyo FE, Gonzaga G, Silverio O, Blas-Marron MG, Muñoz-Jimenez I, Tapia E, Osorio-Alonso H, Madero M, Roncal-Jiménez CA, Weiss I, Glaser J, Johnson RJ Tags: Am J Nephrol Source Type: research

Vascular Calcification Markers and Hemodialysis Vascular Access Complications
Conclusion: Lower fetuin-A and higher OPN and BMP-7 are associated with complications in AVF but not in AVG, suggesting a role for calcification in the pathogenesis AVF failure.Am J Nephrol 2018;48:330 –338 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 31, 2018 Category: Neurology Source Type: research

Vascular Calcification Markers and Hemodialysis Vascular Access Complications.
CONCLUSION: Lower fetuin-A and higher OPN and BMP-7 are associated with complications in AVF but not in AVG, suggesting a role for calcification in the pathogenesis AVF failure. PMID: 30380526 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 31, 2018 Category: Urology & Nephrology Authors: Lyu B, Banerjee T, Scialla JJ, Shafi T, Yevzlin AS, Powe NR, Parekh RS, Astor BC Tags: Am J Nephrol Source Type: research

Meet the Twins: Intradialytic and Interdialytic Hypertension
Am J Nephrol 2018;48:292 –294 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

A Comparative Study of Short-Term Blood Pressure Variability in Hemodialysis Patients with and without Intradialytic Hypertension
Conclusions: BPV is similar between those with and without intradialytic hypertension. However, those with intradialytic hypertension have a sustained increase in systolic and diastolic BP during the entire interdialytic interval.Am J Nephrol 2018;48:295 –305 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Polycystic Kidney Disease Progression: Learning from Europe
Am J Nephrol 2018;48:306 –307 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Autosomal Dominant Polycystic Kidney Disease: Clinical Assessment of Rapid Progression
Conclusions: The ERA-EDTA WGIKD/ERBP algorithm provides a valuable means of identifying in routine clinical practice patients who may be eligible for treatment with tolvaptan. The impact of a new threshold for age and eGFR may increase the percentage of patients to be treated.Am J Nephrol 2018;48:308 –317 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Changing Trends in the Performance of Percutaneous Renal Biopsy from Nephrologist to Interventional Radiologist: A Single-Center Experience
Conclusion: We find that there has been a significant transition over time in the performance of PRB by a nephrologist to IR. The major reason for this is the time burden associated with PRB and the availability of IRs.Am J Nephrol 2018;48:326 –329 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Changing Trends in the Performance of Percutaneous Renal Biopsy from Nephrologist to Interventional Radiologist: A Single-Center Experience.
Abstract BACKGROUND: Percutaneous renal biopsy of native kidneys (PRB) has been an integral part of the practice of nephrology. However, over the past 30 years, PRB has transitioned from a procedure performed only by nephrologists to interventional radiologists (IRs). We surveyed practicing nephrologists completing training in our program to determine the clinical practice patterns of PRB. METHODS: The 78 fellows completing the nephrology program at Rush University Medical Center from June 1984 through June 2017 were successfully contacted and surveyed regarding their opinion on adequacy of their training and...
Source: American Journal of Nephrology - October 24, 2018 Category: Urology & Nephrology Authors: Korbet SM, Whittier WL, Rodby RA Tags: Am J Nephrol Source Type: research

Polycystic Kidney Disease Progression: Learning from Europe.
PMID: 30347387 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Cowley BD Tags: Am J Nephrol Source Type: research

Meet the Twins: Intradialytic and Interdialytic Hypertension.
PMID: 30347388 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Georgianos PI, Agarwal R Tags: Am J Nephrol Source Type: research

Autosomal Dominant Polycystic Kidney Disease: Clinical Assessment of Rapid Progression.
CONCLUSIONS: The ERA-EDTA WGIKD/ERBP algorithm provides a valuable means of identifying in routine clinical practice patients who may be eligible for treatment with tolvaptan. The impact of a new threshold for age and eGFR may increase the percentage of patients to be treated. PMID: 30347391 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Furlano M, Loscos I, Martí T, Bullich G, Ayasreh N, Rius A, Roca L, Ballarín J, Ars E, Torra R Tags: Am J Nephrol Source Type: research