Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study.
Abstract BACKGROUND: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. METHODS: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Rhee EP, Clish CB, Wenger J, Roy J, Elmariah S, Pierce KA, Bullock K, Anderson AH, Gerszten RE, Feldman HI Tags: Am J Nephrol Source Type: research

Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway.
CONCLUSION: Reduced Klotho expression aggravates Tac-induced renal injury via the PI3K-Akt-FoxO pathway. PMID: 27174564 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Jin J, Jin L, Lim SW, Yang CW Tags: Am J Nephrol Source Type: research

Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury.
Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury. Am J Nephrol. 2016 May 13;43(5):375-382 Authors: Kimmel M, Shi J, Wasser C, Biegger D, Alscher MD, Schanz MB Abstract BACKGROUND: Urine microscopy is an established technique to assess kidney disease, and can add valuable information about the mechanism of damage. However, it requires the time and expertise of an experienced nephrologist and, therefore, is typically used for a limited number of patients in practice. A rapid biomarker test that identifies patients from the emergency department (ED) who are likely to hav...
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Kimmel M, Shi J, Wasser C, Biegger D, Alscher MD, Schanz MB Tags: Am J Nephrol Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal
Background: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. Methods: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD-EPIcr,cysc), CKD-EPIcy...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander
Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potent...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury
Background: Urine microscopy is an established technique to assess kidney disease, and can add valuable information about the mechanism of damage. However, it requires the time and expertise of an experienced nephrologist and, therefore, is typically used for a limited number of patients in practice. A rapid biomarker test that identifies patients from the emergency department (ED) who are likely to have positive urine microscopy findings would enable more efficient use of this technique. Methods: Four hundred patients were enrolled in the ED; thereof 362 patients had available both tissue inhibitor of metalloproteinases-2...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study
Background: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. Methods: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway
Conclusion: Reduced Klotho expression aggravates Tac-induced renal injury via the PI3K-Akt-FoxO pathway.Am J Nephrol 2016;43:357-365 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal?
Background: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. Methods: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD-EPIcr,cysc), CKD-EPIcy...
Source: American Journal of Nephrology - May 11, 2016 Category: Neurology Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal?
Abstract BACKGROUND: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. METHODS: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD...
Source: American Journal of Nephrology - May 11, 2016 Category: Urology & Nephrology Authors: Canales MT, Blackwell T, Ishani A, Taylor BC, Hart A, Barrett-Connor E, Lewis C, Beyth RJ, Stone K, Ensrud KE, Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study Tags: Am J Nephrol Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?
Abstract BACKGROUND: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. SUMMARY: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally,...
Source: American Journal of Nephrology - May 11, 2016 Category: Urology & Nephrology Authors: Desmedt V, Desmedt S, Delanghe JR, Speeckaert R, Speeckaert MM Tags: Am J Nephrol Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?
Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potent...
Source: American Journal of Nephrology - May 11, 2016 Category: Neurology Source Type: research

Outcomes of IgA Nephropathy with Segmental Glomerular Necrosis But without Crescent Formation.
CONCLUSIONS: SGN can be found in mild pathological damage patients and is not always associated with crescent formation. Heavier proteinuria was found in these IgAN patients. SGN was not an independent predictor for the prognosis of IgAN. PMID: 27166147 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Tan M, Li W, Zou G, Zhang C, Fang J Tags: Am J Nephrol Source Type: research

Reduced Cardiovascular Mortality Associated with Early Vascular Access Placement in Elderly Patients with Chronic Kidney Disease.
Abstract BACKGROUND: Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this consideration. We assessed whether there has been a parallel decrease in cardiovascular comorbidity in elderly chronic kidney disease (CKD) patients undergoing predialysis access surgery, and whether this impacted clinical outcomes after access creation and cardiovascular events after hemo...
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Lee T, Thamer M, Zhang Q, Zhang Y, Allon M Tags: Am J Nephrol Source Type: research

Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy.
Abstract BACKGROUND: Little is known about the endoplasmic reticulum stress (ERS) marker glucose regulated protein 78 (GRP78) and calcineurin in the kidney in primary membranous nephropathy (PMN) and if they could predict post-cyclosporine treatment outcome. METHODS: This is a retrospective study using a dataset of biopsy-confirmed PMN from Peking Union Medical College Hospital from 1996 to 2014. Seventy-six adult patients treated with cyclosporine as primary immunosuppression for at least 6 months were studied. Immunohistochemistry was used to detect GRP78 and calcineurin in the kidney. Serum calcineurin was...
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Tao J, Zhang W, Wen Y, Sun Y, Chen L, Li H, Li M, Li X, Lafayette RA, Li X Tags: Am J Nephrol Source Type: research

Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study.
CONCLUSIONS: The findings of this exploratory study suggest that older patients with high comorbidities and highly complex regimen are more likely to be adherent based on an objective measure. Future research is needed using objective measures of adherence suitable for all patients and reflecting all medications. PMID: 27166159 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Ghimire S, Peterson GM, Castelino RL, Jose MD, Zaidi ST Tags: Am J Nephrol Source Type: research

Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy
Background: Little is known about the endoplasmic reticulum stress (ERS) marker glucose regulated protein 78 (GRP78) and calcineurin in the kidney in primary membranous nephropathy (PMN) and if they could predict post-cyclosporine treatment outcome. Methods: This is a retrospective study using a dataset of biopsy-confirmed PMN from Peking Union Medical College Hospital from 1996 to 2014. Seventy-six adult patients treated with cyclosporine as primary immunosuppression for at least 6 months were studied. Immunohistochemistry was used to detect GRP78 and calcineurin in the kidney. Serum calcineurin was assayed by ELISA. Pati...
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Outcomes of IgA Nephropathy with Segmental Glomerular Necrosis But without Crescent Formation
Conclusions: SGN can be found in mild pathological damage patients and is not always associated with crescent formation. Heavier proteinuria was found in these IgAN patients. SGN was not an independent predictor for the prognosis of IgAN.Am J Nephrol 2016;43:341-347 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Reduced Cardiovascular Mortality Associated with Early Vascular Access Placement in Elderly Patients with Chronic Kidney Disease
Background: Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this consideration. We assessed whether there has been a parallel decrease in cardiovascular comorbidity in elderly chronic kidney disease (CKD) patients undergoing predialysis access surgery, and whether this impacted clinical outcomes after access creation and cardiovascular events after hemodialysis initiatio...
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study
Conclusions: The findings of this exploratory study suggest that older patients with high comorbidities and highly complex regimen are more likely to be adherent based on an objective measure. Future research is needed using objective measures of adherence suitable for all patients and reflecting all medications.Am J Nephrol 2016;43:318-324 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria.
Abstract BACKGROUND: Primary hyperoxaluria type 1 (PH1) and idiopathic hypercalciuria (IHC) are stone-forming diseases that may result in the formation of calcium (Ca) oxalate (Ox) stones, nephrocalcinosis, and progressive chronic kidney disease (CKD). Poorer clinical outcome in PH1 is segregated by the highest urine (Ur)-Ox (UrOx), while IHC outcomes are not predictable by UrCa. We hypothesized that differences would be found in selected Ur-protein (PRO) patterns in PH1 and IHC, compared to healthy intra-familial sibling controls (C) of PH1 patients. We also hypothesized that the PRO patterns associated with high...
Source: American Journal of Nephrology - May 2, 2016 Category: Urology & Nephrology Authors: Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB Tags: Am J Nephrol Source Type: research

Hydration and Chronic Kidney Disease Progression: A Critical Review of the Evidence.
Abstract We performed a comprehensive literature review to examine evidence on the effects of hydration on the kidney. By reducing vasopressin secretion, increasing water intake may have a beneficial effect on renal function in patients with all forms of chronic kidney disease (CKD) and in those at risk of CKD. This potential benefit may be greater when the kidney is still able to concentrate urine (high fluid intake is contraindicated in dialysis-dependent patients). Increasing water intake is a well-accepted method for preventing renal calculi, and current evidence suggests that recurrent dehydration and heat st...
Source: American Journal of Nephrology - May 2, 2016 Category: Urology & Nephrology Authors: Clark WF, Sontrop JM, Huang SH, Moist L, Bouby N, Bankir L Tags: Am J Nephrol Source Type: research

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria
Background: Primary hyperoxaluria type 1 (PH1) and idiopathic hypercalciuria (IHC) are stone-forming diseases that may result in the formation of calcium (Ca) oxalate (Ox) stones, nephrocalcinosis, and progressive chronic kidney disease (CKD). Poorer clinical outcome in PH1 is segregated by the highest urine (Ur)-Ox (UrOx), while IHC outcomes are not predictable by UrCa. We hypothesized that differences would be found in selected Ur-protein (PRO) patterns in PH1 and IHC, compared to healthy intra-familial sibling controls (C) of PH1 patients. We also hypothesized that the PRO patterns associated with higher UrOx levels wou...
Source: American Journal of Nephrology - May 2, 2016 Category: Neurology Source Type: research

Hydration and Chronic Kidney Disease Progression: A Critical Review of the Evidence
We performed a comprehensive literature review to examine evidence on the effects of hydration on the kidney. By reducing vasopressin secretion, increasing water intake may have a beneficial effect on renal function in patients with all forms of chronic kidney disease (CKD) and in those at risk of CKD. This potential benefit may be greater when the kidney is still able to concentrate urine (high fluid intake is contraindicated in dialysis-dependent patients). Increasing water intake is a well-accepted method for preventing renal calculi, and current evidence suggests that recurrent dehydration and heat stress from extreme ...
Source: American Journal of Nephrology - May 2, 2016 Category: Neurology Source Type: research

Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease
Background: Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseline CKD. Methods: Using current guideline criteria, 1,726 (36.9%) of 4,678 participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure (BP) arm had mild to moderate CKD (CKD1-3B) at baseline. Participants of this study were randomized to intensive (systolic (Source: American ...
Source: American Journal of Nephrology - April 29, 2016 Category: Neurology Source Type: research

Reduced Mortality Associated with Acute Kidney Injury Requiring Dialysis in the United States
Conclusions: The incidence rate of AKI-D has increased considerably in the US since 2001. However, in-hospital mortality associated with AKI-D hospital admissions has decreased significantly.Am J Nephrol 2016;43:261-270 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 29, 2016 Category: Neurology Source Type: research

Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study.
CONCLUSION: In this open, prospective study, RTX appeared to be very effective and safe in the treatment of the most severe cases of MC. PMID: 27161362 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2016 Category: Urology & Nephrology Authors: Roccatello D, Sciascia S, Baldovino S, Rossi D, Alpa M, Naretto C, Di Simone D, Menegatti E Tags: Am J Nephrol Source Type: research

Reduced Mortality Associated with Acute Kidney Injury Requiring Dialysis in the United States.
CONCLUSIONS: The incidence rate of AKI-D has increased considerably in the US since 2001. However, in-hospital mortality associated with AKI-D hospital admissions has decreased significantly. PMID: 27161485 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2016 Category: Urology & Nephrology Authors: Brown JR, Rezaee ME, Hisey WM, Cox KC, Matheny ME, Sarnak MJ Tags: Am J Nephrol Source Type: research

Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease.
Abstract BACKGROUND: Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseline CKD. METHODS: Using current guideline criteria, 1,726 (36.9%) of 4,678 participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure (BP) arm had mild to moderate CKD (CKD1-3B) at baseline. Participants of this study were randomized to intensive (systolic
Source: American Journal of Nephrology - April 28, 2016 Category: Urology & Nephrology Authors: Papademetriou V, Zaheer M, Doumas M, Lovato L, Applegate WB, Tsioufis C, Mottle A, Punthakee Z, Cushman WC, ACCORD Study Group Tags: Am J Nephrol Source Type: research

Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study
Conclusion: In this open, prospective study, RTX appeared to be very effective and safe in the treatment of the most severe cases of MC.Am J Nephrol 2016;43:251-260 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2016 Category: Neurology Source Type: research

A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia.
CONCLUSION: We report the identification of a novel mutation in SLC2A9 as the cause of RHUC2 in a native Austrian family. We show that glucose transporter 9 mutations cause severe hypouricemia in homozygous individuals and confirm the high risk of AKI in male individuals harbouring these mutations. In our literature review, we provide an overview of the putative underlying pathophysiology, potential renal complications, findings on kidney biopsy as well as potential long-time renal sequelae. PMID: 27116386 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2016 Category: Urology & Nephrology Authors: Windpessl M, Ritelli M, Wallner M, Colombi M Tags: Am J Nephrol Source Type: research

A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia
Conclusion: We report the identification of a novel mutation in SLC2A9 as the cause of RHUC2 in a native Austrian family. We show that glucose transporter 9 mutations cause severe hypouricemia in homozygous individuals and confirm the high risk of AKI in male individuals harbouring these mutations. In our literature review, we provide an overview of the putative underlying pathophysiology, potential renal complications, findings on kidney biopsy as well as potential long-time renal sequelae.Am J Nephrol 2016;43:245-250 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2016 Category: Neurology Source Type: research

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients
For patients on dialysis, infection is the second leading cause of mortality. Iron metabolism should be considered in the pathogenesis of infectious disease, as high local iron concentrations favor the growth of many microbes. This review is intended to provide information regarding iron metabolism and infection in chronic kidney disease (CKD) patients. There are 2 reasons these patients may be vulnerable to infection: (1) the excessive iron administered to treat renal anemia could be associated with impairments of the host's innate immune response, (2) CKD-associated inflammation could cause dysregulated iron metabolism. ...
Source: American Journal of Nephrology - April 21, 2016 Category: Neurology Source Type: research

Pharmacokinetics, Pharmacodynamics, and Safety of Single-Dose Rivaroxaban in Chronic Hemodialysis
Conclusions: Changes in PK and PD parameters in chronic dialysis patients were generally comparable to changes observed previously in patients with moderate-to-severe renal impairment who were not undergoing dialysis, and support use of a 15-mg dose in this patient population.Am J Nephrol 2016;43:229-236 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Neurology Source Type: research

Rivaroxaban in Chronic Hemodialysis Patients
Am J Nephrol 2016;43:227-228 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Neurology Source Type: research

Yet Another Vitamin D Analogue for the Management of Secondary Hyperparathyroidism: A Triton among the Minnows?
Am J Nephrol 2016;43:221-224 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Neurology Source Type: research

Pharmacokinetics, Pharmacodynamics, and Safety of Single-Dose Rivaroxaban in Chronic Hemodialysis.
CONCLUSIONS: Changes in PK and PD parameters in chronic dialysis patients were generally comparable to changes observed previously in patients with moderate-to-severe renal impairment who were not undergoing dialysis, and support use of a 15-mg dose in this patient population. PMID: 27100875 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Urology & Nephrology Authors: Dias C, Moore KT, Murphy J, Ariyawansa J, Smith W, Mills RM, Weir MR Tags: Am J Nephrol Source Type: research

Rivaroxaban in Chronic Hemodialysis Patients.
PMID: 27100995 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Urology & Nephrology Authors: Muster H, Alcorn H Tags: Am J Nephrol Source Type: research

Yet Another Vitamin D Analogue for the Management of Secondary Hyperparathyroidism: A Triton among the Minnows?
PMID: 27101129 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 21, 2016 Category: Urology & Nephrology Authors: Obi Y, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Iron Localization and Infectious Disease in Chronic Kidney Disease Patients.
Abstract For patients on dialysis, infection is the second leading cause of mortality. Iron metabolism should be considered in the pathogenesis of infectious disease, as high local iron concentrations favor the growth of many microbes. This review is intended to provide information regarding iron metabolism and infection in chronic kidney disease (CKD) patients. There are 2 reasons these patients may be vulnerable to infection: (1) the excessive iron administered to treat renal anemia could be associated with impairments of the host's innate immune response, (2) CKD-associated inflammation could cause dysregulated...
Source: American Journal of Nephrology - April 21, 2016 Category: Urology & Nephrology Authors: Nakanishi T, Kuragano T, Nanami M, Hasuike Y Tags: Am J Nephrol Source Type: research

Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD.
This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these variables after the exercise than healthy individuals. METHODS: Nine patients with stages 2-3 CKD (50 ± 8 years) and 12 healthy volunteers (50 ± 5 years) underwent 2 sessions, conducted in a random order: exercise (45 min, cycle ergometer, 50% of peak oxygen uptake) and rest (seated, 45 min). Sixty min...
Source: American Journal of Nephrology - April 20, 2016 Category: Urology & Nephrology Authors: Aprile DC, Oneda B, Gusmão JL, Costa LA, Forjaz CL, Mion D, Tinucci T Tags: Am J Nephrol Source Type: research

Use of 2MD, a Novel Oral Calcitriol Analog, in Hemodialysis Patients with Secondary Hyperparathyroidism.
CONCLUSIONS: In hemodialysis patients with SHPT, 2MD, at thrice weekly oral doses of 440 and 550 ng, is well tolerated and effectively suppresses PTH without hypercalcemia. Future studies are needed to study the long-term implications of treating ESRD patients with this novel VDRA. PMID: 27096733 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 20, 2016 Category: Urology & Nephrology Authors: Pandey R, Zella J, Clagett-Dame M, Plum LA, DeLuca HF, Coyne DW Tags: Am J Nephrol Source Type: research

Use of 2MD, a Novel Oral Calcitriol Analog, in Hemodialysis Patients with Secondary Hyperparathyroidism
Conclusions: In hemodialysis patients with SHPT, 2MD, at thrice weekly oral doses of 440 and 550 ng, is well tolerated and effectively suppresses PTH without hypercalcemia. Future studies are needed to study the long-term implications of treating ESRD patients with this novel VDRA.Am J Nephrol 2016;43:213-220 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 20, 2016 Category: Neurology Source Type: research

Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD
This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these variables after the exercise than healthy individuals. Methods: Nine patients with stages 2-3 CKD (50 ± 8 years) and 12 healthy volunteers (50 ± 5 years) underwent 2 sessions, conducted in a random order: exercise (45 min, cycle ergometer, 50% of peak oxygen uptake) and rest (seated, 45 min). Sixty minutes ...
Source: American Journal of Nephrology - April 20, 2016 Category: Neurology Source Type: research

Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury.
CONCLUSION: Functional/histologic hallmarks of renal injury were ameliorated, renal functioning improved, intra-renal hypoxia decreased and intra-renal regeneration processes were activated. Thus, DNAse-I treatment protected the kidney from deleterious consequences of ischemia-induced AKI. PMID: 27073834 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2016 Category: Urology & Nephrology Authors: Peer V, Abu Hamad R, Berman S, Efrati S Tags: Am J Nephrol Source Type: research

Regulation of IgA Class Switch Recombination in Immunoglobulin A Nephropathy: Retinoic Acid Signaling and BATF.
CONCLUSION: These data point toward the role of RA signaling together with BATF in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with neoantigen results in impaired mucosal and systemic IgA responses. PMID: 27073891 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2016 Category: Urology & Nephrology Authors: He L, Peng X, Chen Y, Liu G, Liu Z, Zhu J, Liu Y, Liu H, Liang Y, Liu F, Sun L, Peng Y Tags: Am J Nephrol Source Type: research

Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury
Conclusion: Functional/histologic hallmarks of renal injury were ameliorated, renal functioning improved, intra-renal hypoxia decreased and intra-renal regeneration processes were activated. Thus, DNAse-I treatment protected the kidney from deleterious consequences of ischemia-induced AKI.Am J Nephrol 2016;43:195-205 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2016 Category: Neurology Source Type: research

Regulation of IgA Class Switch Recombination in Immunoglobulin A Nephropathy: Retinoic Acid Signaling and BATF
Conclusion: These data point toward the role of RA signaling together with BATF in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with neoantigen results in impaired mucosal and systemic IgA responses.Am J Nephrol 2016;43:179-194 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2016 Category: Neurology Source Type: research

Elevated Troponin Levels in Stable Patients Undergoing Hemodialysis: A Red Flag or a Red Herring
Am J Nephrol 2016;43:170-172 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2016 Category: Neurology Source Type: research

High Ultrafiltration Rates Increase Troponin Levels in Stable Hemodialysis Patients
Conclusions: A high UF rate during HD is associated with a biochemical evidence of myocardial injury. If confirmed, efforts to avoid rapid UF, protect residual kidney function or minimize weight gain between sessions may impact cardiovascular outcomes in this high-risk population.Am J Nephrol 2016;43:173-178 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 12, 2016 Category: Neurology Source Type: research