Prolonged Duration of Renal Recovery Following ANCA-Associated Glomerulonephritis
Background: As renal biopsies are not routinely repeated to monitor treatment response in anti-neutrophil cytoplasm antibody (ANCA)-associated glomerulonephritis, serum creatinine (SC) and proteinuria assessed by urine protein:creatinine ratio (UPCR) measurements are relied upon to provide a non-invasive estimate of disease activity within the kidney. However, sparse information exists about the time to achieve maximal improvement in these parameters, which has important implications for treatment decisions and disease-scoring systems. Methods: We analysed patients with ANCA-associated glomerulonephritis and renal impairme...
Source: American Journal of Nephrology - March 23, 2016 Category: Neurology Source Type: research

Prolonged Duration of Renal Recovery Following ANCA-Associated Glomerulonephritis.
Abstract BACKGROUND: As renal biopsies are not routinely repeated to monitor treatment response in anti-neutrophil cytoplasm antibody (ANCA)-associated glomerulonephritis, serum creatinine (SC) and proteinuria assessed by urine protein:creatinine ratio (UPCR) measurements are relied upon to provide a non-invasive estimate of disease activity within the kidney. However, sparse information exists about the time to achieve maximal improvement in these parameters, which has important implications for treatment decisions and disease-scoring systems. METHODS: We analysed patients with ANCA-associated glomerulonephr...
Source: American Journal of Nephrology - March 22, 2016 Category: Urology & Nephrology Authors: Oomatia A, Moran SM, Kennedy C, Sequeira R, Hamour S, Burns A, Little MA, Salama AD Tags: Am J Nephrol Source Type: research

Trends and Outcomes of Severe Sepsis in Patients on Maintenance Dialysis.
The objectives of this study were to measure the incidence and outcomes of severe sepsis in those on maintenance dialysis. METHODS: Using data from Nationwide Inpatient Sample database from 2005 to 2010, we included all hospitalizations of adults with severe sepsis based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Those on maintenance dialysis were identified by ICD-9-CM codes. We calculated incidence of severe sepsis and mortality. We used logistic regression to assess independent effect of maintenance dialysis status on mortality. RESULTS: Of the esti...
Source: American Journal of Nephrology - March 10, 2016 Category: Urology & Nephrology Authors: Sakhuja A, Nanchal RS, Gupta S, Amer H, Kumar G, Albright RC, Kashani KB Tags: Am J Nephrol Source Type: research

Impact of Pre-Dialysis Care on Clinical Outcomes in Peritoneal Dialysis Patients
This study aimed at analyzing the impact of pre-dialysis care on these outcomes. Methods: All incident patients starting PD between 2004 and 2011 in a Brazilian prospective cohort were included in this analysis. Patients were divided into 2 groups: early pre-dialysis care (90 days of follow-up by a nephrology team); and late pre-dialysis care (absent or less than 90 days follow-up). The socio-demographic, clinical and biochemical characteristics between the 2 groups were compared. Risk factors for the time to the first peritonitis episode, technique failure and mortality based on Cox proportional hazards models. Results: F...
Source: American Journal of Nephrology - March 9, 2016 Category: Neurology Source Type: research

Trends and Outcomes of Severe Sepsis in Patients on Maintenance Dialysis
The objectives of this study were to measure the incidence and outcomes of severe sepsis in those on maintenance dialysis. Methods: Using data from Nationwide Inpatient Sample database from 2005 to 2010, we included all hospitalizations of adults with severe sepsis based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Those on maintenance dialysis were identified by ICD-9-CM codes. We calculated incidence of severe sepsis and mortality. We used logistic regression to assess independent effect of maintenance dialysis status on mortality. Results: Of the estimated 5,00...
Source: American Journal of Nephrology - March 9, 2016 Category: Neurology Source Type: research

Impact of Pre-Dialysis Care on Clinical Outcomes in Peritoneal Dialysis Patients.
This study aimed at analyzing the impact of pre-dialysis care on these outcomes. METHODS: All incident patients starting PD between 2004 and 2011 in a Brazilian prospective cohort were included in this analysis. Patients were divided into 2 groups: early pre-dialysis care (90 days of follow-up by a nephrology team); and late pre-dialysis care (absent or less than 90 days follow-up). The socio-demographic, clinical and biochemical characteristics between the 2 groups were compared. Risk factors for the time to the first peritonitis episode, technique failure and mortality based on Cox proportional hazards models. ...
Source: American Journal of Nephrology - March 9, 2016 Category: Urology & Nephrology Authors: Spigolon DN, de Moraes TP, Figueiredo AE, Modesto AP, Barretti P, Bastos MG, Barreto DV, Pecoits-Filho R, BRAZPD Investigators Tags: Am J Nephrol Source Type: research

Changes in Markers of Mineral and Bone Disorders and Mortality in Incident Hemodialysis Patients
We examined the association of change in MBD markers (serum phosphorus (Phos), albumin-corrected calcium (CaAlb), intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP)) during the first 6 months of hemodialysis (HD) with all-cause mortality across baseline MBD strata using survival models adjusted for clinical characteristics and laboratory measurements in 102,754 incident HD patients treated in a large dialysis organization between 2007 and 2011. Results: Across all MBD markers (Phos, CaAlb, iPTH and ALP), among patients whose baseline MBD levels were higher than the reference range, increase in MBD levels was ...
Source: American Journal of Nephrology - March 8, 2016 Category: Neurology Source Type: research

Changes in Markers of Mineral and Bone Disorders and Mortality in Incident Hemodialysis Patients.
We examined the association of change in MBD markers (serum phosphorus (Phos), albumin-corrected calcium (CaAlb), intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP)) during the first 6 months of hemodialysis (HD) with all-cause mortality across baseline MBD strata using survival models adjusted for clinical characteristics and laboratory measurements in 102,754 incident HD patients treated in a large dialysis organization between 2007 and 2011. RESULTS: Across all MBD markers (Phos, CaAlb, iPTH and ALP), among patients whose baseline MBD levels were higher than the reference range, increase in MBD levels...
Source: American Journal of Nephrology - March 8, 2016 Category: Urology & Nephrology Authors: Soohoo M, Feng M, Obi Y, Streja E, Rhee CM, Lau WL, Wang J, Ravel VA, Brunelli S, Kovesdy CP, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Vascular Endothelial Growth Factor and Podocyte Protection in Chronic Hypoxia: Effects of Endothelin-A Receptor Antagonism.
CONCLUSION: ET-A antagonism preserves podocyte viability and integrity under chronic hypoxia, whereas ET-B antagonism exacerbates podocyte dysfunction and death. Enhanced bioavailability of VEGF after ET-A antagonism could be a pivotal mechanism of podocyte protection that significantly contributes to ET-A receptor blockade-induced renal recovery in chronic RVD. PMID: 26930122 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 2, 2016 Category: Urology & Nephrology Authors: Harvey TW, Engel JE, Chade AR Tags: Am J Nephrol Source Type: research

Life and Death of Podocytes: Not Only a Matter of Vascular Endothelial Growth Factor.
PMID: 26930245 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 2, 2016 Category: Urology & Nephrology Authors: Novelli R, Benigni A Tags: Am J Nephrol Source Type: research

Vascular Endothelial Growth Factor and Podocyte Protection in Chronic Hypoxia: Effects of Endothelin-A Receptor Antagonism
Conclusion: ET-A antagonism preserves podocyte viability and integrity under chronic hypoxia, whereas ET-B antagonism exacerbates podocyte dysfunction and death. Enhanced bioavailability of VEGF after ET-A antagonism could be a pivotal mechanism of podocyte protection that significantly contributes to ET-A receptor blockade-induced renal recovery in chronic RVD.Am J Nephrol 2016;43:74-84 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 1, 2016 Category: Neurology Source Type: research

Life and Death of Podocytes: Not Only a Matter of Vascular Endothelial Growth Factor
Am J Nephrol 2016;43:71-73 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 1, 2016 Category: Neurology Source Type: research

Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges.
CONCLUSION: Adrenocorticotropic hormone gel might be useful in the management of complex cases of idiopathic MN. PMID: 26914654 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 26, 2016 Category: Urology & Nephrology Authors: El-Husseini A, Saxon D, Jennings S, Cornea V, Beck L, Sawaya BP Tags: Am J Nephrol Source Type: research

Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges
Conclusion: Adrenocorticotropic hormone gel might be useful in the management of complex cases of idiopathic MN.Am J Nephrol 2016;43:65-70 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 25, 2016 Category: Neurology Source Type: research

Cognitive Function and White Matter Changes Associated with Renal Transplantation.
Abstract BACKGROUND: End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cognition and associated changes in brain structure after renal transplantation can help define the mechanisms underlying cognitive impairment in ESRD. METHODS: We conducted a prospective, observational cohort study in ESRD patients listed for renal transplantation and followed them post-tran...
Source: American Journal of Nephrology - February 20, 2016 Category: Urology & Nephrology Authors: Gupta A, Lepping RJ, Yu AS, Perea RD, Honea RA, Johnson DK, Brooks WM, Burns JM Tags: Am J Nephrol Source Type: research

Brain Imaging and Cognition after Kidney Transplantation.
PMID: 26895038 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2016 Category: Urology & Nephrology Authors: Srinivas T Tags: Am J Nephrol Source Type: research

Averting the Legacy of Kidney Disease - Focus on Childhood.
Abstract World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for ...
Source: American Journal of Nephrology - February 20, 2016 Category: Urology & Nephrology Authors: Ingelfinger JR, Kalantar-Zadeh K, Schaefer F, World Kidney Day Steering Committee Tags: Am J Nephrol Source Type: research

Mortality Outcomes of Patients with Chronic Kidney Disease and Chronic Obstructive Pulmonary Disease
Conclusions: COPD is associated with higher risk for death among those with CKD, and an underlying lung disease accounts for significant proportion of deaths. These data highlight the need for further prospective studies to understand the underlying mechanisms and potential interventions to improve outcomes in this population.Am J Nephrol 2016;43:39-46 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 19, 2016 Category: Neurology Source Type: research

Averting the Legacy of Kidney Disease - Focus on Childhood
World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for date newborns have...
Source: American Journal of Nephrology - February 19, 2016 Category: Neurology Source Type: research

Cognitive Function and White Matter Changes Associated with Renal Transplantation
Background: End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cognition and associated changes in brain structure after renal transplantation can help define the mechanisms underlying cognitive impairment in ESRD. Methods: We conducted a prospective, observational cohort study in ESRD patients listed for renal transplantation and followed them post-transplantation. We assesse...
Source: American Journal of Nephrology - February 19, 2016 Category: Neurology Source Type: research

Brain Imaging and Cognition after Kidney Transplantation
Am J Nephrol 2016;43:47-49 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 19, 2016 Category: Neurology Source Type: research

Mortality Outcomes of Patients with Chronic Kidney Disease and Chronic Obstructive Pulmonary Disease.
CONCLUSIONS: COPD is associated with higher risk for death among those with CKD, and an underlying lung disease accounts for significant proportion of deaths. These data highlight the need for further prospective studies to understand the underlying mechanisms and potential interventions to improve outcomes in this population. PMID: 26891053 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 19, 2016 Category: Urology & Nephrology Authors: Navaneethan SD, Schold JD, Huang H, Nakhoul G, Jolly SE, Arrigain S, Dweik RA, Nally JV Tags: Am J Nephrol Source Type: research

Annual Iron Loss Associated with Hemodialysis.
CONCLUSIONS: Five hundred milligram of annual iron supplementation might be sufficient to maintain iron status in hemodialysis patients, which is less than the dose recommended as 1,000-2,000 mg a year. Further study will be required to verify this iron supplementation dosage with recent hemodialysis procedure. PMID: 26885949 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 18, 2016 Category: Urology & Nephrology Authors: Tsukamoto T, Matsubara T, Akashi Y, Kondo M, Yanagita M Tags: Am J Nephrol Source Type: research

Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease
Conclusions: These data indicate that while calcitriol effectively lowered PTH in rats with CKD, it did little to prevent the negative effects of secondary hyperparathyroidism on the skeleton.Am J Nephrol 2016;43:20-31 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 17, 2016 Category: Neurology Source Type: research

Annual Iron Loss Associated with Hemodialysis
Conclusions: Five hundred milligram of annual iron supplementation might be sufficient to maintain iron status in hemodialysis patients, which is less than the dose recommended as 1,000-2,000 mg a year. Further study will be required to verify this iron supplementation dosage with recent hemodialysis procedure.Am J Nephrol 2016;43:32-38 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 17, 2016 Category: Neurology Source Type: research

Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease.
CONCLUSIONS: These data indicate that while calcitriol effectively lowered PTH in rats with CKD, it did little to prevent the negative effects of secondary hyperparathyroidism on the skeleton. PMID: 26881752 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 17, 2016 Category: Urology & Nephrology Authors: Newman CL, Tian N, Hammond MA, Wallace JM, Brown DM, Chen NX, Moe SM, Allen MR Tags: Am J Nephrol Source Type: research

Acknowledgement to the Reviewers
Am J Nephrol 2015;42:460-462 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 10, 2016 Category: Neurology Source Type: research

Contents Vol. 42, 2015
Am J Nephrol 2015;42:I-V (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 10, 2016 Category: Neurology Source Type: research

Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications
Background: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. Summary: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indications. The evidence-based a...
Source: American Journal of Nephrology - February 5, 2016 Category: Neurology Source Type: research

Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications.
Abstract BACKGROUND: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. SUMMARY: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indication...
Source: American Journal of Nephrology - February 5, 2016 Category: Urology & Nephrology Authors: Fiorentino M, Bolignano D, Tesar V, Pisano A, Van Biesen W, D'Arrigo G, Tripepi G, Gesualdo L, ERA-EDTA Immunonephrology Working Group Tags: Am J Nephrol Source Type: research

Novel Stratification of Mortality Risk by Kidney Disease Stage
Conclusion: IMRS is a strong predictor of mortality in patients with CKD and is robustly complementary to CKD stage in refining risk prediction. Given the universal availability and low cost of the CBC and BMP, IMRS may be of a substantial value in CKD risk assessment and management.Am J Nephrol 2015;42:443-450 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2016 Category: Neurology Source Type: research

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature
We present a case of a 49-year-old female with an atypical presentation of LN who initially presented with new-onset hypertension, edema, arthritis, serositis and recently diagnosed leukocytoclastic vasculitis who later developed acute kidney injury, hematuria and nephrotic syndrome. Laboratory testing showed mixed cryoglobulinemia and elevated perinuclear anti-neutrophil cytoplasmic (p-ANCA) and myeloperoxidase (MPO) antibodies. SLE-related serologies were negative. Kidney biopsy showed diffuse proliferative global glomerulonephritis with a full-house nephropathy pattern on immunofluorescence suggestive of LN. Due to high...
Source: American Journal of Nephrology - January 27, 2016 Category: Neurology Source Type: research

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature.
We present a case of a 49-year-old female with an atypical presentation of LN who initially presented with new-onset hypertension, edema, arthritis, serositis and recently diagnosed leukocytoclastic vasculitis who later developed acute kidney injury, hematuria and nephrotic syndrome. Laboratory testing showed mixed cryoglobulinemia and elevated perinuclear anti-neutrophil cytoplasmic (p-ANCA) and myeloperoxidase (MPO) antibodies. SLE-related serologies were negative. Kidney biopsy showed diffuse proliferative global glomerulonephritis with a full-house nephropathy pattern on immunofluorescence suggestive of LN. Due to high...
Source: American Journal of Nephrology - January 27, 2016 Category: Urology & Nephrology Authors: Simmons SC, Smith ML, Chang-Miller A, Keddis MT Tags: Am J Nephrol Source Type: research

Novel Stratification of Mortality Risk by Kidney Disease Stage.
CONCLUSION: IMRS is a strong predictor of mortality in patients with CKD and is robustly complementary to CKD stage in refining risk prediction. Given the universal availability and low cost of the CBC and BMP, IMRS may be of a substantial value in CKD risk assessment and management. PMID: 26812216 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2016 Category: Urology & Nephrology Authors: Rassa AC, Horne BD, McCubrey RO, Bair TL, Muhlestein JB, Morris DR, Anderson JL Tags: Am J Nephrol Source Type: research

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers.
CONCLUSIONS: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. Published by S. Karger AG, Basel. PMID: 26800100 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 23, 2016 Category: Urology & Nephrology Authors: Little DJ, Yuan CM, Thurlow JS, Gounden V, Doi SQ, Pruziner A, Abbott KC, Theeler BJ, Olson SW Tags: Am J Nephrol Source Type: research

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers
Conclusions: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. Published by S. Karger AG, BaselAm J Nephrol 2015;42:436-442 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 22, 2016 Category: Neurology Source Type: research

Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study
Background: Higher dietary acid load can result in metabolic acidosis and is associated with faster kidney disease progression in patients with chronic kidney disease (CKD). However, the relationship between dietary acid load and incident CKD has not been evaluated. Methods: We conducted prospective analyses of the Atherosclerosis Risk in Communities study participants without CKD at baseline (1987-1989, n = 15,055). Dietary acid load was estimated using the equation for potential renal acid load by Remer and Manz, incorporating dietary intake data from a food frequency questionnaire. Incident CKD was assessed from baselin...
Source: American Journal of Nephrology - January 21, 2016 Category: Neurology Source Type: research

Food for Thought: Diet as a Risk Factor for CKD
Am J Nephrol 2015;42:425-426 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2016 Category: Neurology Source Type: research

Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study.
Abstract BACKGROUND: Higher dietary acid load can result in metabolic acidosis and is associated with faster kidney disease progression in patients with chronic kidney disease (CKD). However, the relationship between dietary acid load and incident CKD has not been evaluated. METHODS: We conducted prospective analyses of the Atherosclerosis Risk in Communities study participants without CKD at baseline (1987-1989, n = 15,055). Dietary acid load was estimated using the equation for potential renal acid load by Remer and Manz, incorporating dietary intake data from a food frequency questionnaire. Incident CKD wa...
Source: American Journal of Nephrology - January 21, 2016 Category: Urology & Nephrology Authors: Rebholz CM, Coresh J, Grams ME, Steffen LM, Anderson CA, Appel LJ, Crews DC Tags: Am J Nephrol Source Type: research

Food for Thought: Diet as a Risk Factor for CKD.
PMID: 26789532 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2016 Category: Urology & Nephrology Authors: Chen X, Beddhu S Tags: Am J Nephrol Source Type: research

Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis.
CONCLUSIONS: Our study had demonstrated a favorable test performance and cost efficiency of 2-stage BKV screening. PMID: 26756552 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 13, 2016 Category: Urology & Nephrology Authors: Ma MK, Leung AY, Lo KY, Lio WI, Chan HW, Wong I, Hau AK, Tam CH, Wong AK, Kuok UI, Chau KF, Fung SK, Kwan TH, Wong SS, Tang SC Tags: Am J Nephrol Source Type: research

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine.
CONCLUSION: In conclusion, these results confirmed our hypothesis that protein markers in urinary exosomes better reflected the underlying protein changes in the kidney than in whole urine samples. PMID: 26756605 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 13, 2016 Category: Urology & Nephrology Authors: Gudehithlu KP, Garcia-Gomez I, Vernik J, Brecklin C, Kraus M, Cimbaluk DJ, Hart P, Dunea G, Arruda JA, Singh AK Tags: Am J Nephrol Source Type: research

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study
Background: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and AKI as assessed by neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine (SCr) and kinetic estimated glomerular filtration rate (KeGFR). Results: Patients undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present between SUA and NGAL measured at...
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis
Conclusions: Our study had demonstrated a favorable test performance and cost efficiency of 2-stage BKV screening.Am J Nephrol 2015;42:410-417 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine
Conclusion: In conclusion, these results confirmed our hypothesis that protein markers in urinary exosomes better reflected the underlying protein changes in the kidney than in whole urine samples.Am J Nephrol 2015;42:418-424 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study.
Abstract BACKGROUND: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. METHODS: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and AKI as assessed by neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine (SCr) and kinetic estimated glomerular filtration rate (KeGFR). RESULTS: Patients undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present betw...
Source: American Journal of Nephrology - January 6, 2016 Category: Urology & Nephrology Authors: Ejaz AA, Alquadan KF, Dass B, Shimada M, Kanbay M, Johnson RJ Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 and Vascular Calcification: Is It Set in Stone
Am J Nephrol 2015;42:389-390 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 23, 2015 Category: Neurology Source Type: research

Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus.
Abstract BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. The role of FGF23 in vascular calcification remains controversial. METHODS: Relationships between FGF23 and coronary artery calcified atherosclerotic plaque (CAC), aortoiliac calcified plaque (CP), carotid artery CP, volumetric bone mineral density (vBMD), albuminuria, and estimated glomerular filtration rate (eGFR) were determined in 545 African Americans with type 2 diabetes (T2D) and preserved kidney function in African American-Diabetes Heart Study par...
Source: American Journal of Nephrology - December 23, 2015 Category: Urology & Nephrology Authors: Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 and Vascular Calcification: Is It Set in Stone?
PMID: 26693905 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 23, 2015 Category: Urology & Nephrology Authors: Chan GC, Tang SC Tags: Am J Nephrol Source Type: research

Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus
Background: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. The role of FGF23 in vascular calcification remains controversial. Methods: Relationships between FGF23 and coronary artery calcified atherosclerotic plaque (CAC), aortoiliac calcified plaque (CP), carotid artery CP, volumetric bone mineral density (vBMD), albuminuria, and estimated glomerular filtration rate (eGFR) were determined in 545 African Americans with type 2 diabetes (T2D) and preserved kidney function in African American-Diabetes Heart Study participants. Generalized ...
Source: American Journal of Nephrology - December 22, 2015 Category: Neurology Source Type: research