Obesity and Kidney Disease: Hidden Consequences of the Epidemic
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in the long-term. The ...
Source: American Journal of Nephrology - February 8, 2017 Category: Neurology Source Type: research

Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients.
Abstract BACKGROUND: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. METHODS: This is a multicenter randomized controlled trial performed on 163 patients from 17 dialysis centers in Shanghai who were allocated to high- (n = 98) and standard-dose groups (n = 65) and followed through 96 weeks of study period. Therapeutic approaches were given to increase spKt/V to over 1.70 in the high-dose group. Data were collected every 12-24 weeks. The primary outcomes were al...
Source: American Journal of Nephrology - February 7, 2017 Category: Urology & Nephrology Authors: Fan Q, Yan Y, Gu L, He L, Chen N, Jiang G, Yuan L, Xue J, Zhang Y, Ma J, Jin H, Yuan W, Guo Z, Guo L, Wang N, Zhang W, Ye Z, Mao P, Pi X, Lu R, Zhu M, Zhang W, Ni Z, Qian J, Pang H Tags: Am J Nephrol Source Type: research

Obesity and Kidney Disease: Hidden Consequences of the Epidemic.
Abstract Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in t...
Source: American Journal of Nephrology - February 7, 2017 Category: Urology & Nephrology Authors: Kovesdy CP, Furth SL, Zoccali C, World Kidney Day Steering Committee Tags: Am J Nephrol Source Type: research

Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients
Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD.Methods: This is a multicenter randomized controlled trial performed on 163 patients from 17 dialysis centers in Shanghai who were allocated to high- (n = 98) and standard-dose groups (n = 65) and followed through 96 weeks of study period. Therapeutic approaches were given to increase spKt/V to over 1.70 in the high-dose group. Data were collected every 12-24 weeks. The primary outcomes were all-cause mortality and ma...
Source: American Journal of Nephrology - February 7, 2017 Category: Neurology Source Type: research

Rationale and Design of a Clinical Trial Investigating Tolvaptan Safety and Efficacy in Autosomal Dominant Polycystic Kidney Disease.
CONCLUSION: Replicating Evidence of Preserved Renal Function: An Investigation of Tolvaptan Safety and Efficacy (REPRISE) determines whether tolvaptan administered over 1 year exhibits disease-modifying properties in ADPKD patients with late stage 2 to early stage 4 CKD, which provides an important therapeutic advancement for this difficult-to-treat disease. PMID: 28166521 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 6, 2017 Category: Urology & Nephrology Authors: Torres VE, Devuyst O, Chapman AB, Gansevoort RT, Perrone RD, Ouyang J, Blais JD, Czerwiec FS, Sergeyeva O, REPRISE Trial Investigators Tags: Am J Nephrol Source Type: research

Rationale and Design of a Clinical Trial Investigating Tolvaptan Safety and Efficacy in Autosomal Dominant Polycystic Kidney Disease
Conclusion: Replicating Evidence of Preserved Renal Function: An Investigation of Tolvaptan Safety and Efficacy (REPRISE) determines whether tolvaptan administered over 1 year exhibits disease-modifying properties in ADPKD patients with late stage 2 to early stage 4 CKD, which provides an important therapeutic advancement for this difficult-to-treat disease.Am J Nephrol 2017;45:257-266 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 6, 2017 Category: Neurology Source Type: research

Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis.
CONCLUSION: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome. PMID: 28161700 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 3, 2017 Category: Urology & Nephrology Authors: Payan Schober F, Jobson MA, Poulton CJ, Singh HK, Nickeleit V, Falk RJ, Jennette JC, Nachman PH, Pendergraft Iii WF Tags: Am J Nephrol Source Type: research

Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis
Conclusion: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome.Am J Nephrol 2017;45:248-256 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 3, 2017 Category: Neurology Source Type: research

The Association between Biomarker Profiles, Etiology of Chronic Kidney Disease, and Mortality.
CONCLUSIONS: Biomarkers profiles differ according to the etiology of CKD and are associated with mortality. PMID: 28147348 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2017 Category: Urology & Nephrology Authors: Langsford D, Tang M, Cheikh Hassan HI, Djurdjev O, Sood MM, Levin A Tags: Am J Nephrol Source Type: research

The Association between Biomarker Profiles, Etiology of Chronic Kidney Disease, and Mortality
Conclusions: Biomarkers profiles differ according to the etiology of CKD and are associated with mortality.Am J Nephrol 2017;45:226-234 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2017 Category: Neurology Source Type: research

History of Erythropoiesis-Stimulating Agents, the Development of Biosimilars, and the Future of Anemia Treatment in Nephrology.
Abstract BACKGROUND: Exogenous replacement of erythropoietin (EPO) by recombinant human EPO has been considered a standard of care for the treatment of anemia in patients with chronic kidney disease for more than 20 years. Genetically engineered biologic proteins derived from human, animal, or microorganism sources are a major area of growth in modern medical care, accounting for one-third of new drug approvals in the past decade. Despite benefit to patients, the use of biologics comes at a significant cost, representing one of the fastest growing segments of strained healthcare budgets around the world. SUMM...
Source: American Journal of Nephrology - January 31, 2017 Category: Urology & Nephrology Authors: Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

History of Erythropoiesis-Stimulating Agents, the Development of Biosimilars, and the Future of Anemia Treatment in Nephrology
Background: Exogenous replacement of erythropoietin (EPO) by recombinant human EPO has been considered a standard of care for the treatment of anemia in patients with chronic kidney disease for more than 20 years. Genetically engineered biologic proteins derived from human, animal, or microorganism sources are a major area of growth in modern medical care, accounting for one-third of new drug approvals in the past decade. Despite benefit to patients, the use of biologics comes at a significant cost, representing one of the fastest growing segments of strained healthcare budgets around the world.Summary: Biosimilars, or bio...
Source: American Journal of Nephrology - January 31, 2017 Category: Neurology Source Type: research

Acute Kidney Injury and In-Hospital Mortality after Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention: A Nationwide Study.
Abstract BACKGROUND: Post-procedural acute kidney injury (AKI) is associated with significantly increased short- and long-term mortalities, and renal loss. Few studies have compared the incidence of post-procedural AKI and in-hospital mortality between 2 major modalities of revascularization - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - and results have been inconsistent. METHODS: We generated a propensity score-matched cohort that includes a total of 286,670 hospitalizations with multi-vessel coronary disease undergoing CABG or PCI (2004-2012) from the National Inpat...
Source: American Journal of Nephrology - January 30, 2017 Category: Urology & Nephrology Authors: Shen W, Aguilar R, Montero AR, Fernandez SJ, Taylor AJ, Wilcox CS, Lipkowitz MS, Umans JG Tags: Am J Nephrol Source Type: research

Acute Kidney Injury and In-Hospital Mortality after Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention: A Nationwide Study
Background: Post-procedural acute kidney injury (AKI) is associated with significantly increased short- and long-term mortalities, and renal loss. Few studies have compared the incidence of post-procedural AKI and in-hospital mortality between 2 major modalities of revascularization - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - and results have been inconsistent.Methods: We generated a propensity score-matched cohort that includes a total of 286,670 hospitalizations with multi-vessel coronary disease undergoing CABG or PCI (2004-2012) from the National Inpatient Sample database. We...
Source: American Journal of Nephrology - January 30, 2017 Category: Neurology Source Type: research

ANCA Associated Vasculitis Secondary to Levamisole-Adultered Cocaine with Associated Membranous Nephropathy: A Case Series.
CONCLUSIONS: Clinicians should be aware of this novel association of LAC with MN. PMID: 28132051 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Collister D, Sathianathan C, Ryz K, Karpinski M, Bernstein K, Gibson IW Tags: Am J Nephrol Source Type: research

ANCA Associated Vasculitis Secondary to Levamisole-Adultered Cocaine with Associated Membranous Nephropathy: A Case Series
Conclusions: Clinicians should be aware of this novel association of LAC with MN.Am J Nephrol 2017;45:209-216 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2017 Category: Neurology Source Type: research

Insights from Screening a Racially and Ethnically Diverse Population for Chronic Kidney Disease.
CONCLUSIONS: NKFH-KEDS participants of older age; Asian and Pacific Islander race/ethnicity; and with obesity, hypertension, and diabetes had higher risk of kidney damage defined by elevated ACR and urine albumin levels. Further studies are needed to determine whether targeted screening programs can result in timely identification of CKD and implementation of interventions that reduce cardiovascular disease, death, and progression to end-stage renal disease. PMID: 28125810 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 26, 2017 Category: Urology & Nephrology Authors: Wong LL, Kalantar-Zadeh K, Page V, Hayashida G, You AS, Rhee CM Tags: Am J Nephrol Source Type: research

Insights from Screening a Racially and Ethnically Diverse Population for Chronic Kidney Disease
Conclusions: NKFH-KEDS participants of older age; Asian and Pacific Islander race/ethnicity; and with obesity, hypertension, and diabetes had higher risk of kidney damage defined by elevated ACR and urine albumin levels. Further studies are needed to determine whether targeted screening programs can result in timely identification of CKD and implementation of interventions that reduce cardiovascular disease, death, and progression to end-stage renal disease.Am J Nephrol 2017;45:200-208 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 26, 2017 Category: Neurology Source Type: research

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients.
Abstract BACKGROUND: Anemia, a common complication of chronic kidney disease (CKD), has previously been attributed primarily to decreased production of erythropoietin. More recently, it has become apparent that the etiology of anemia involves several other factors, most notably dysfunctional iron metabolism, mediated via increased hepcidin activity and reduced clearance. Current management of anemia in patients with advanced CKD is based on erythropoiesis-stimulating agents and iron supplementation, along with red blood cell transfusions when necessary; however, safety considerations associated with these therapie...
Source: American Journal of Nephrology - January 24, 2017 Category: Urology & Nephrology Authors: Locatelli F, Fishbane S, Block GA, Macdougall IC Tags: Am J Nephrol Source Type: research

Association of Albuminuria and Estimated Glomerular Filtration Rate with Functional Performance Measures in Older Adults with Chronic Kidney Disease
Background: Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear.Methods: This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from the Systolic Blood Pressure Intervention Trial. We evaluated estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) as predictors of 3 measures of functional status: EuroQol-5 Dimensional (EQ-5D) score, Falls Efficacy Scale (FES) score, and gait spe ed. Linear regression mo...
Source: American Journal of Nephrology - January 24, 2017 Category: Neurology Source Type: research

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Background: Anemia, a common complication of chronic kidney disease (CKD), has previously been attributed primarily to decreased production of erythropoietin. More recently, it has become apparent that the etiology of anemia involves several other factors, most notably dysfunctional iron metabolism, mediated via increased hepcidin activity and reduced clearance. Current management of anemia in patients with advanced CKD is based on erythropoiesis-stimulating agents and iron supplementation, along with red blood cell transfusions when necessary; however, safety considerations associated with these therapies highlight the ne...
Source: American Journal of Nephrology - January 24, 2017 Category: Neurology Source Type: research

Albuminuria: A Novel Marker for Functional Impairment in Older Adults
Am J Nephrol 2017;45:170-171 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 23, 2017 Category: Neurology Source Type: research

Association of Albuminuria and Estimated Glomerular Filtration Rate with Functional Performance Measures in Older Adults with Chronic Kidney Disease.
Abstract BACKGROUND: Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS: This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from the Systolic Blood Pressure Intervention Trial. We evaluated estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) as predictors of 3 measures of functional status: EuroQol-5 Dimensional (EQ-5D) score, Falls Efficacy Scale (FES) score, and gait spee...
Source: American Journal of Nephrology - January 20, 2017 Category: Urology & Nephrology Authors: Wolfgram DF, Garcia K, Evans G, Zamanian S, Tang R, Wiegmann T, Sharma R, Campbell R, Whittle J, SPRINT Study Research Group Tags: Am J Nephrol Source Type: research

Mortality after Renal Allograft Failure and Return to Dialysis.
Abstract INTRODUCTION: The outcomes of patients who fail their kidney transplant and return to dialysis (RTD) has not been investigated in a nationally representative sample. We hypothesized that variations in management of transplant chronic kidney disease stage 5 leading to kidney allograft failure (KAF) and RTD, such as access, nutrition, timing of dialysis, and anemia management predict long-term survival. METHODS: We used an incident cohort of patients from the United States Renal Data System who initiated hemodialysis between January 1, 2003 and December 31, 2008, after KAF. We used Cox regression analy...
Source: American Journal of Nephrology - January 20, 2017 Category: Urology & Nephrology Authors: Brar A, Markell M, Stefanov DG, Timpo E, Jindal RM, Nee R, Sumrani N, John D, Tedla F, Salifu MO Tags: Am J Nephrol Source Type: research

Albuminuria: A Novel Marker for Functional Impairment in Older Adults?
PMID: 28110340 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 20, 2017 Category: Urology & Nephrology Authors: Heung M Tags: Am J Nephrol Source Type: research

Mortality after Renal Allograft Failure and Return to Dialysis
Introduction: The outcomes of patients who fail their kidney transplant and return to dialysis (RTD) has not been investigated in a nationally representative sample. We hypothesized that variations in management of transplant chronic kidney disease stage 5 leading to kidney allograft failure (KAF) and RTD, such as access, nutrition, timing of dialysis, and anemia management predict long-term survival.Methods: We used an incident cohort of patients from the United States Renal Data System who initiated hemodialysis between January 1, 2003 and December 31, 2008, after KAF. We used Cox regression analysis for statistical asso...
Source: American Journal of Nephrology - January 20, 2017 Category: Neurology Source Type: research

Albuminuria: A Novel Marker for Functional Impairment in Older Adults?
Am J Nephrol 2017;45:170-171 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 20, 2017 Category: Neurology Source Type: research

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review.
Abstract BACKGROUND: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers. SUMMARY: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-ind...
Source: American Journal of Nephrology - January 11, 2017 Category: Urology & Nephrology Authors: Wanchoo R, Karam S, Uppal NN, Barta VS, Deray G, Devoe C, Launay-Vacher V, Jhaveri KD, Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors Tags: Am J Nephrol Source Type: research

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Background: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers.Summary: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-induced kidney toxicity. In...
Source: American Journal of Nephrology - January 11, 2017 Category: Neurology Source Type: research

Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents.
Abstract BACKGROUND: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. METHODS: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary...
Source: American Journal of Nephrology - January 5, 2017 Category: Urology & Nephrology Authors: Avasare RS, Rosenstiel PE, Zaky ZS, Tsapepas DS, Appel GB, Markowitz GS, Bomback AS, Canetta PA Tags: Am J Nephrol Source Type: research

Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents
Background: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression.Methods: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to rec...
Source: American Journal of Nephrology - January 5, 2017 Category: Neurology Source Type: research

Is Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
PMID: 28006763 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2016 Category: Urology & Nephrology Authors: Filler G, McIntyre C Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 Predicts All-Cause Mortality in a Dose-Response Fashion in Pre-Dialysis Patients with Chronic Kidney Disease.
This study aimed to summarize and quantify the predictive effects of FGF23 among the pre-dialysis CKD stages 1-5 population. METHODS: Data sources included PubMed, EMBASE, and Web of Science. Prospective cohort studies assessing the associations between FGF23 and all-cause mortality, CVD, and renal events in CKD patients were selected. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using the random-effects model. The composite higher or the highest level in FGF23 categories of each study was considered the high level. The reference level was regarded as the low level in the overall analys...
Source: American Journal of Nephrology - December 22, 2016 Category: Urology & Nephrology Authors: Xue C, Yang B, Zhou C, Dai B, Liu Y, Mao Z, Yu S, Mei C Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 Predicts All-Cause Mortality in a Dose-Response Fashion in Pre-Dialysis Patients with Chronic Kidney Disease
This study aimed to summarize and quantify the predictive effects of FGF23 among the pre-dialysis CKD stages 1-5 population.Methods: Data sources included PubMed, EMBASE, and Web of Science. Prospective cohort studies assessing the associations between FGF23 and all-cause mortality, CVD, and renal events in CKD patients were selected. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using the random-effects model. The composite higher or the highest level in FGF23 categories of each study was considered the high level. The reference level was regarded as the low level in the overall analysis. Th...
Source: American Journal of Nephrology - December 22, 2016 Category: Neurology Source Type: research

Is Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
Am J Nephrol 2017;45:146-148 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2016 Category: Neurology Source Type: research

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study
Background: The role of high density lipoprotein-raising interventions in addition to statin therapy in patients with diabetes remains controversial. Chronic kidney disease (CKD) is a strong modifier of cardiovascular (CV) outcomes. We therefore investigated the impact of CKD status at baseline on outcomes in patients with diabetes randomized to standard statin or statin plus fenofibrate treatment in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial.Methods: Among 5,464 participants in the ACCORD lipid trial, 3,554 (65%) were free of CKD at baseline, while 1,910 (35%) had mild to moderate CKD. Diff...
Source: American Journal of Nephrology - December 19, 2016 Category: Neurology Source Type: research

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study.
Abstract BACKGROUND: The role of high density lipoprotein-raising interventions in addition to statin therapy in patients with diabetes remains controversial. Chronic kidney disease (CKD) is a strong modifier of cardiovascular (CV) outcomes. We therefore investigated the impact of CKD status at baseline on outcomes in patients with diabetes randomized to standard statin or statin plus fenofibrate treatment in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial. METHODS: Among 5,464 participants in the ACCORD lipid trial, 3,554 (65%) were free of CKD at baseline, while 1,910 (35%) had mi...
Source: American Journal of Nephrology - December 16, 2016 Category: Urology & Nephrology Authors: Papademetriou V, Lovato L, Tsioufis C, Cushman W, Applegate WB, Mottle A, Punthakee Z, Nylen E, Doumas M, ACCORD Study Group Tags: Am J Nephrol Source Type: research

Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
Conclusion: Daprodustat 4-10 mg once-daily produced dose-dependent increase in hemoglobin relative to placebo in Japanese HD subjects. The doses evaluated in the study have moderately increased endogenous EPO without changes in circulating VEGF levels.Am J Nephrol 2017;45:127-135 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 15, 2016 Category: Neurology Source Type: research

Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects.
CONCLUSION: Daprodustat 4-10 mg once-daily produced dose-dependent increase in hemoglobin relative to placebo in Japanese HD subjects. The doses evaluated in the study have moderately increased endogenous EPO without changes in circulating VEGF levels. PMID: 27978511 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 15, 2016 Category: Urology & Nephrology Authors: Akizawa T, Tsubakihara Y, Nangaku M, Endo Y, Nakajima H, Kohno T, Imai Y, Kawase N, Hara K, Lepore J, Cobitz A Tags: Am J Nephrol Source Type: research

Does Serum HCO3 Predict Risk for Cardiovascular Disease
Am J Nephrol 2017;45:115-117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 12, 2016 Category: Neurology Source Type: research

Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis
Conclusion: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure.Am J Nephrol 2017;45:118-126 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Does Serum HCO < sub > 3 < /sub > Predict Risk for Cardiovascular Disease?
Am J Nephrol 2017;45:115-117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients
Background: We evaluated the prevalence, determinants and prognosis value of pulmonary hypertension (PH) in non-dialysis chronic kidney disease (CKD) patients.Methods: This is a prospective study with stages 3-5 non-dialysis-dependent CKD patients. PH was estimated by Doppler echocardiography and defined as a pulmonary artery systolic pressure above 35 mm Hg.Results: Three hundred fifty-three patients were recruited, of whom 94 (26.6%) had PH. Prevalence of PH increased with the decline of renal function: 21.6, 24.1, and 31.7% in stages 3, 4, and 5, respectively. Independent predictors of PH were age, estimated glomerular ...
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis.
CONCLUSION: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure. PMID: 27941322 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 9, 2016 Category: Urology & Nephrology Authors: Kendrick JB, Zelnick L, Chonchol MB, Siscovick D, Hoofnagle AN, Ix JH, Sarnak M, Shlipak MG, Kestenbaum B, de Boer IH Tags: Am J Nephrol Source Type: research

Does Serum HCO3 Predict Risk for Cardiovascular Disease?
PMID: 27941338 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 9, 2016 Category: Urology & Nephrology Authors: Wesson DE Tags: Am J Nephrol Source Type: research

Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients.
cute;mez JM Abstract BACKGROUND: We evaluated the prevalence, determinants and prognosis value of pulmonary hypertension (PH) in non-dialysis chronic kidney disease (CKD) patients. METHODS: This is a prospective study with stages 3-5 non-dialysis-dependent CKD patients. PH was estimated by Doppler echocardiography and defined as a pulmonary artery systolic pressure above 35 mm Hg. RESULTS: Three hundred fifty-three patients were recruited, of whom 94 (26.6%) had PH. Prevalence of PH increased with the decline of renal function: 21.6, 24.1, and 31.7% in stages 3, 4, and 5, respectively. Independent predic...
Source: American Journal of Nephrology - December 9, 2016 Category: Urology & Nephrology Authors: Reque J, Garcia-Prieto A, Linares T, Vega A, Abad S, Panizo N, Quiroga B, Collado Boira EJ, López-Gómez JM Tags: Am J Nephrol Source Type: research

Acknowledgement to the Reviewers
Am J Nephrol 2016;44:493-495 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 7, 2016 Category: Neurology Source Type: research

Contents Vol. 44, 2016
Am J Nephrol 2016;44:I-V (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 7, 2016 Category: Neurology Source Type: research

The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation
Background: Non-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes.Methods: This was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival.Results: The number of transplants that were included in the analysis was 4,646 (3,656 with complet...
Source: American Journal of Nephrology - December 2, 2016 Category: Neurology Source Type: research

Adherence in Kidney Transplant Recipients
Am J Nephrol 2017;45:89-90 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 2, 2016 Category: Neurology Source Type: research