Efficacy of Prophylactic Antibiotics at Peritoneal Catheter Insertion on Early Peritonitis: Data from the Catheter Section of the French Language Peritoneal Dialysis Registry.
CONCLUSION: There is a beneficial effect of prophylactic antibiotic used prior to peritoneal catheter placement, on the occurence of early peritonitis. However, the beneficial effect could be masked by a centre effect. PMID: 27784007 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2016 Category: Urology & Nephrology Authors: Lanot A, Lobbedez T, Bechade C, Verger C, Fabre E, Dratwa M, Vernier I Tags: Am J Nephrol Source Type: research

Does Intragastric Balloon Treatment for Obesity in Chronic Kidney Disease Heighten Acute Kidney Injury Risk?
CONCLUSIONS: Treatment with IGB has only moderate efficacy on weight loss; yet it results in a high rate of complications in obese patients with established CKD. The risk of AKI may be raised due to increased risk of dehydration secondary to gastrointestinal symptoms associated with IGB placement and reduced baseline kidney function. PMID: 27784008 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2016 Category: Urology & Nephrology Authors: MacLaughlin HL, Macdougall IC, Hall WL, Dew T, Mantzoukis K, Oben JA Tags: Am J Nephrol Source Type: research

Circulating Progenitor Cells Affect Thrombosis of Dialysis Arteriovenous Fistulas
Background: Arteriovenous fistula (AVF) thrombosis is a relevant cause of morbidity in hemodialysis (HD) patients. The number of circulating endothelial progenitor cells (EPCs) has been identified as a surrogate marker for vascular repair and health. Deficiency of EPCs has been demonstrated in dialysis patients to be associated with vascular events. Nonetheless, their role in thrombosis of AVFs remains unknown.Methods: From January 2010 to May 2013, 147 HD patients with dysfunctional AVFs were enrolled. Surface makers including CD34, KDR and CD133 were used in combination to determine the number of circulating EPCs. All pa...
Source: American Journal of Nephrology - October 26, 2016 Category: Neurology Source Type: research

Importance of the Endothelium in Arteriovenous Fistula Outcomes
Am J Nephrol 2016;44:426-427 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2016 Category: Neurology Source Type: research

Efficacy of Prophylactic Antibiotics at Peritoneal Catheter Insertion on Early Peritonitis: Data from the Catheter Section of the French Language Peritoneal Dialysis Registry
Conclusion: There is a beneficial effect of prophylactic antibiotic used prior to peritoneal catheter placement, on the occurence of early peritonitis. However, the beneficial effect could be masked by a centre effect.Am J Nephrol 2016;44:419-425 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2016 Category: Neurology Source Type: research

Does Intragastric Balloon Treatment for Obesity in Chronic Kidney Disease Heighten Acute Kidney Injury Risk?
Conclusions: Treatment with IGB has only moderate efficacy on weight loss; yet it results in a high rate of complications in obese patients with established CKD. The risk of AKI may be raised due to increased risk of dehydration secondary to gastrointestinal symptoms associated with IGB placement and reduced baseline kidney function.Am J Nephrol 2016;44:411-418 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2016 Category: Neurology Source Type: research

Patiromer Decreases Serum Potassium and Phosphate Levels in Patients on Hemodialysis
Background: Persistent hyperkalemia (serum potassium (K) ≥5.5 mEq/l) is a common condition in hemodialysis (HD) patients, is associated with increased mortality, and treatment options are limited. The effect of patiromer, a gastrointestinal K binder, on serum K was examined in HD patients.Methods: Six hyperkalemic HD patients (5 anuric) were admitted to clinical research units for 15 days (1 pretreatment week and 1 patiromer treatment week) and they received a controlled diet with identical meals on corresponding days of pretreatment and treatment weeks. Phosphate (P) binders were discontinued on admission. Patiromer, 1...
Source: American Journal of Nephrology - October 26, 2016 Category: Neurology Source Type: research

Cardiac Hepcidin Expression Associates with Injury Independent of Iron.
Abstract BACKGROUND: Hepcidin regulates systemic iron homeostasis by downregulating the iron exporter ferroportin. Circulating hepcidin is mainly derived from the liver but hepcidin is also produced in the heart. We studied the differential and local regulation of hepcidin gene expression in response to myocardial infarction (MI) and/or chronic kidney disease (CKD). We hypothesized that cardiac hepcidin gene expression is induced by and regulated to severity of cardiac injury, either through direct (MI) or remote (CKD) stimuli, as well as through increased local iron content. METHODS: Nine weeks after subtota...
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: van Breda GF, Bongartz LG, Zhuang W, van Swelm RP, Pertijs J, Braam B, Cramer MJ, Swinkels DW, Doevendans PA, Verhaar MC, Masereeuw R, Joles JA, Gaillard CA Tags: Am J Nephrol Source Type: research

Early Activation of PINCH/ Glycogen-Synthase Kinase 3 β/ERK Pathway in Obstructive Nephropathy Rat Model.
CONCLUSIONS: PINCH/GSK3β/ERK pathway was early molecular responses to obstructed kidney induced by UUO in rat. PMID: 27771700 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: Jia L, Li X, Gu Y, Cui W Tags: Am J Nephrol Source Type: research

Role of the Renal Microcirculation in Progression of Chronic Kidney Injury in Obesity.
Abstract BACKGROUND: Obesity is largely responsible for the growing incidence and prevalence of diabetes, cardiovascular and renal diseases. Current strategies to prevent and treat obesity and its consequences have been insufficient to reverse the ongoing trends. Lifestyle modification or pharmacological therapies often produce modest weight loss which is not sustained and recurrence of obesity is frequently observed, leading to progression of target organ damage in many obese subjects. Therefore, research efforts have focused not only on the factors that regulate energy balance, but also on understanding mechanis...
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: Chade AR, Hall JE Tags: Am J Nephrol Source Type: research

High Coronary Heart Disease Risk in Hemodialysis Patients with Central Sleep Apnea: A Pilot Study.
Abstract BACKGROUND: The high prevalence of sleep apnea is reported in hemodialysis patients despite the low prevalence of obesity. The present study compared the occurrence of central sleep apnea (CSA) in hemodialysis patients with that in non-hemodialysis patients, and its association with new-onset coronary heart disease (CHD) events. METHODS: Seventy-three hemodialysis and 444 non-hemodialysis patients were examined for CSA and obstructive sleep apnea (OSA) occurrence using polysomnography. Hemodialysis patients were monitored for the occurrence of new-onset CHD events. RESULTS: Hemodialysis patients...
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: Sakura M, Inaba M, Yoda K, Ichii M, Yamada S, Yamakawa T, Ishimura E, Okuno S, Shoji S Tags: Am J Nephrol Source Type: research

Magnesium and Kidney Health - More on the 'Forgotten Electrolyte'.
PMID: 27771706 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: Vormann J Tags: Am J Nephrol Source Type: research

Dietary Magnesium and Kidney Function Decline: The Healthy Aging in Neighborhoods of Diversity across the Life Span Study.
CONCLUSIONS: In this urban population, lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline. PMID: 27771720 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Urology & Nephrology Authors: Rebholz CM, Tin A, Liu Y, Kuczmarski MF, Evans MK, Zonderman AB, Crews DC Tags: Am J Nephrol Source Type: research

Early Activation of PINCH/ Glycogen-Synthase Kinase 3 β/ERK Pathway in Obstructive Nephropathy Rat Model
Conclusions: PINCH/GSK3 β/ERK pathway was early molecular responses to obstructed kidney induced by UUO in rat.Am J Nephrol 2016;44:396-403 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

High Coronary Heart Disease Risk in Hemodialysis Patients with Central Sleep Apnea: A Pilot Study
Background: The high prevalence of sleep apnea is reported in hemodialysis patients despite the low prevalence of obesity. The present study compared the occurrence of central sleep apnea (CSA) in hemodialysis patients with that in non-hemodialysis patients, and its association with new-onset coronary heart disease (CHD) events.Methods: Seventy-three hemodialysis and 444 non-hemodialysis patients were examined for CSA and obstructive sleep apnea (OSA) occurrence using polysomnography. Hemodialysis patients were monitored for the occurrence of new-onset CHD events.Results: Hemodialysis patients had a significantly higher ce...
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

Dietary Magnesium and Kidney Function Decline: The Healthy Aging in Neighborhoods of Diversity across the Life Span Study
Conclusions: In this urban population, lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline.Am J Nephrol 2016;44:381-387 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

Magnesium and Kidney Health - More on the ‘Forgotten Electrolyte'
Am J Nephrol 2016;44:379-380 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

Cardiac Hepcidin Expression Associates with Injury Independent of Iron
Background: Hepcidin regulates systemic iron homeostasis by downregulating the iron exporter ferroportin. Circulating hepcidin is mainly derived from the liver but hepcidin is also produced in the heart. We studied the differential and local regulation of hepcidin gene expression in response to myocardial infarction (MI) and/or chronic kidney disease (CKD). We hypothesized that cardiac hepcidin gene expression is induced by and regulated to severity of cardiac injury, either through direct (MI) or remote (CKD) stimuli, as well as through increased local iron content.Methods: Nine weeks after subtotal nephrectomy (SNX) or s...
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

Role of the Renal Microcirculation in Progression of Chronic Kidney Injury in Obesity
Background: Obesity is largely responsible for the growing incidence and prevalence of diabetes, cardiovascular and renal diseases. Current strategies to prevent and treat obesity and its consequences have been insufficient to reverse the ongoing trends. Lifestyle modification or pharmacological therapies often produce modest weight loss which is not sustained and recurrence of obesity is frequently observed, leading to progression of target organ damage in many obese subjects. Therefore, research efforts have focused not only on the factors that regulate energy balance, but also on understanding mechanisms of target organ...
Source: American Journal of Nephrology - October 21, 2016 Category: Neurology Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study.
Abstract BACKGROUND: Stroke prevention in dialysis-dependent patients with atrial fibrillation (AF) is an unresolved clinical dilemma. Indeed, no randomized controlled trial evaluating the efficacy and safety of oral anticoagulants in this population, has been conducted so far. Observational research on the use of warfarin in patients on dialysis has shown conflicting results. This uncertainty is mirrored by the wide variations in warfarin prescription patterns across centers. We sought to evaluate the association between the use of vitamin K antagonists (VKAs) and mortality among hemodialysis patient with AF and ...
Source: American Journal of Nephrology - October 20, 2016 Category: Urology & Nephrology Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Am J Nephrol Source Type: research

Oral Anticoagulation in End-Stage Renal Disease: Is It Time to Absolve Warfarin?
PMID: 27598337 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2016 Category: Urology & Nephrology Authors: Genovesi S Tags: Am J Nephrol Source Type: research

Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor- α Levels in Chronic Kidney Disease - A 5-Year Prospective Study.
Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor-α Levels in Chronic Kidney Disease - A 5-Year Prospective Study. Am J Nephrol. 2016;44(4):268-275 Authors: Wallquist C, Mansouri L, Norrbäck M, Hylander B, Jacobson SH, Lundahl J Abstract BACKGROUND: Despite the absence of clinical symptoms, patients with chronic kidney disease (CKD) exhibit elevated levels of pro-inflammatory markers. To investigate whether it is possible to detect inflammatory activity and altered monocyte function at an early stage of renal disease, we studied patients with CKD stages 2-3 ov...
Source: American Journal of Nephrology - October 20, 2016 Category: Urology & Nephrology Authors: Wallquist C, Mansouri L, Norrbäck M, Hylander B, Jacobson SH, Lundahl J Tags: Am J Nephrol Source Type: research

Hypoxia-Inducible Factor-1 α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.
CONCLUSIONS: These findings suggest that HIF-1α induced by hypoxia activates the TGF-β/SMAD3 pathway. This mechanism may promote kidney injury, especially by upregulating genes related to fibrosis. PMID: 27607351 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2016 Category: Urology & Nephrology Authors: Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H Tags: Am J Nephrol Source Type: research

Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy.
CONCLUSION: Male obese ZSF-1 rats represent an important DN model, manifesting key pathophysiological features including metabolic syndrome, proteinuria, progressive tubular and glomerular fibrosis, and transient hyperfiltration followed by progressive decline in renal function. Uninephrectomy significantly accelerated disease progression. Females were less severe in disease manifestation. Several urinary and tissue biomarkers were identified in the male obese rats that tracked with disease progression. PMID: 27736813 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 13, 2016 Category: Urology & Nephrology Authors: Su Z, Widomski D, Ma J, Namovic M, Nikkel A, Leys L, Olson L, Salte K, Donnelly-Roberts D, Esbenshade T, McGaraughty S Tags: Am J Nephrol Source Type: research

Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy
Conclusion: Male obese ZSF-1 rats represent an important DN model, manifesting key pathophysiological features including metabolic syndrome, proteinuria, progressive tubular and glomerular fibrosis, and transient hyperfiltration followed by progressive decline in renal function. Uninephrectomy significantly accelerated disease progression. Females were less severe in disease manifestation. Several urinary and tissue biomarkers were identified in the male obese rats that tracked with disease progression.Am J Nephrol 2016;44:339-353 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 13, 2016 Category: Neurology Source Type: research

ST-Segment Elevation Myocardial Infarction in Dialysis and Renal Transplant Patients. How Does It Compare to That in the General Population?
Am J Nephrol 2016;44:327-328 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 11, 2016 Category: Neurology Source Type: research

ST-Segment Elevation Myocardial Elevation in Dialysis and Renal Transplant Patients. How Does It Compare to That in the General Population?
PMID: 27705980 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 5, 2016 Category: Urology & Nephrology Authors: Bolad IA Tags: Am J Nephrol Source Type: research

National Impact of Maintenance Dialysis or Renal Transplantation on Outcomes Following ST Elevation Myocardial Infarction.
This study included STEMI hospitalizations in patients aged ≥20 using Nationwide Inpatient Sample Database from 2006 to 2010. Primary outcomes were incidence and trends of STEMI hospitalizations based on renal function status. We also looked at utilization of revascularization procedures, all-cause-hospital mortality and predictors of mortality. RESULTS: Of the estimated 882,447 STEMI hospitalizations, 11,383 were on maintenance dialysis and 1,076 had renal transplants. The incidence of STEMI was over 7 times in patients on maintenance dialysis and 1.73 times in renal transplant recipients compared to the general p...
Source: American Journal of Nephrology - October 5, 2016 Category: Urology & Nephrology Authors: Sakhuja A, Wright RS, Schold JD, McCarthy JT, Williams AW, Amer H, Albright RC Tags: Am J Nephrol Source Type: research

National Impact of Maintenance Dialysis or Renal Transplantation on Outcomes Following ST Elevation Myocardial Infarction
This study included STEMI hospitalizations in patients aged ≥20 using Nationwide Inpatient Sample Database from 2006 to 2010. Primary outcomes were incidence and trends of STEMI hospitalizations based on renal function status. We also looked at utilization of revascularization procedures, all-cause-hospital mortality and predictors of mortality.Results: Of the estimated 882,447 STEMI hospitalizations, 11,383 were on maintenance dialysis and 1,076 had renal transplants. The incidence of STEMI was over 7 times in patients on maintenance dialysis and 1.73 times in renal transplant recipients compared to the general populat...
Source: American Journal of Nephrology - October 5, 2016 Category: Neurology Source Type: research

ST-Segment Elevation Myocardial Elevation in Dialysis and Renal Transplant Patients. How Does It Compare to That in the General Population?
Am J Nephrol 2016;44:327-328 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 5, 2016 Category: Neurology Source Type: research

Use of Extended-Release Calcifediol to Treat Secondary Hyperparathyroidism in Stages 3 and 4 Chronic Kidney Disease.
CONCLUSION: Oral ER calcifediol is safe and effective in treating SHPT and vitamin D insufficiency in CKD. PMID: 27676085 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 27, 2016 Category: Urology & Nephrology Authors: Sprague SM, Crawford PW, Melnick JZ, Strugnell SA, Ali S, Mangoo-Karim R, Lee S, Petkovich PM, Bishop CW Tags: Am J Nephrol Source Type: research

Use of Extended-Release Calcifediol to Treat Secondary Hyperparathyroidism in Stages 3 and 4 Chronic Kidney Disease
Conclusion: Oral ER calcifediol is safe and effective in treating SHPT and vitamin D insufficiency in CKD.Am J Nephrol 2016;44:316-325 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 27, 2016 Category: Neurology Source Type: research

Medical Neighborhood Model for the Care of Chronic Kidney Disease Patients.
CONCLUSIONS: We implemented a PCMN that allowed for easy identification of a high-risk, high-cost population of CKD patients and optimized their care to reflect guideline-based standards. PMID: 27657555 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 22, 2016 Category: Urology & Nephrology Authors: Smith ZG, McNicoll L, Clark TL, Cohen AJ, Ross AL, Monteiro JF, Dworkin LD Tags: Am J Nephrol Source Type: research

Medical Neighborhood Model for the Care of Chronic Kidney Disease Patients
Conclusions: We implemented a PCMN that allowed for easy identification of a high-risk, high-cost population of CKD patients and optimized their care to reflect guideline-based standards.Am J Nephrol 2016;44:308-315 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 22, 2016 Category: Neurology Source Type: research

Intensive Home Hemodialysis Results in Regression of Left Ventricular Hypertrophy and Better Clinical Outcomes.
CONCLUSIONS: Regression of LVH with intensive hemodialysis is associated with favorable clinical outcomes. PMID: 27640181 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 16, 2016 Category: Urology & Nephrology Authors: Trinh E, Chan CT Tags: Am J Nephrol Source Type: research

Intensive Home Hemodialysis Results in Regression of Left Ventricular Hypertrophy and Better Clinical Outcomes
Conclusions: Regression of LVH with intensive hemodialysis is associated with favorable clinical outcomes.Am J Nephrol 2016;44:300-307 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 16, 2016 Category: Neurology Source Type: research

Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts.
CONCLUSION: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients. PMID: 27626625 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2016 Category: Urology & Nephrology Authors: Menn-Josephy H, Lee CS, Nolin A, Christov M, Rybin DV, Weinberg JM, Henderson J, Bonegio R, Havasi A Tags: Am J Nephrol Source Type: research

Should We Always Defer Treatment of Kidney Disease When There Is Extensive Interstitial Fibrosis on Biopsy?
Abstract Severity of interstitial fibrosis and tubular atrophy (IFTA) seen on kidney biopsy has been used by nephrologist as prognostic marker of kidney disease. While IFTA is a very strong predictor of kidney failure, some patients with severe fibrosis will still not progress to kidney failure within 5 years. Treatment of underlying kidney disease in select patients with severe IFTA should be considered when risks of treatment are reasonable despite the low potential for benefit. PMID: 27626794 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2016 Category: Urology & Nephrology Authors: Hommos MS, Rule AD Tags: Am J Nephrol Source Type: research

Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts
Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients.Am J Nephrol 2016;44:289-299 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2016 Category: Neurology Source Type: research

Should We Always Defer Treatment of Kidney Disease When There Is Extensive Interstitial Fibrosis on Biopsy?
Severity of interstitial fibrosis and tubular atrophy (IFTA) seen on kidney biopsy has been used by nephrologist as prognostic marker of kidney disease. While IFTA is a very strong predictor of kidney failure, some patients with severe fibrosis will still not progress to kidney failure within 5 years. Treatment of underlying kidney disease in select patients with severe IFTA should be considered when risks of treatment are reasonable despite the low potential for benefit.Am J Nephrol 2016;44:286-288 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2016 Category: Neurology Source Type: research

Hypoxia-Inducible Factor-1 α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells
Conclusions: These findings suggest that HIF-1 α induced by hypoxia activates the TGF-β/SMAD3 pathway. This mechanism may promote kidney injury, especially by upregulating genes related to fibrosis.Am J Nephrol 2016;44:276-285 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 9, 2016 Category: Neurology Source Type: research

Hypoxia-Inducible Factor-1 α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.
CONCLUSIONS: These findings suggest that HIF-1α induced by hypoxia activates the TGF-β/SMAD3 pathway. This mechanism may promote kidney injury, especially by upregulating genes related to fibrosis. PMID: 27607351 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 8, 2016 Category: Urology & Nephrology Authors: Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H Tags: Am J Nephrol Source Type: research

Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor- α Levels in Chronic Kidney Disease - A 5-Year Prospective Study.
Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor-α Levels in Chronic Kidney Disease - A 5-Year Prospective Study. Am J Nephrol. 2016 Sep 8;44(4):268-275 Authors: Wallquist C, Mansouri L, Norrbäck M, Hylander B, Jacobson SH, Lundahl J Abstract BACKGROUND: Despite the absence of clinical symptoms, patients with chronic kidney disease (CKD) exhibit elevated levels of pro-inflammatory markers. To investigate whether it is possible to detect inflammatory activity and altered monocyte function at an early stage of renal disease, we studied patients with CKD stages ...
Source: American Journal of Nephrology - September 7, 2016 Category: Urology & Nephrology Authors: Wallquist C, Mansouri L, Norrbäck M, Hylander B, Jacobson SH, Lundahl J Tags: Am J Nephrol Source Type: research

Erratum.
Authors: PMID: 27598797 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2016 Category: Urology & Nephrology Tags: Am J Nephrol Source Type: research

Oral Anticoagulation in End-Stage Renal Disease: Is It Time to Absolve Warfarin
Am J Nephrol 2016;44:255-257 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2016 Category: Neurology Source Type: research

Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor- α Levels in Chronic Kidney Disease - A 5-Year Prospective Study
Background: Despite the absence of clinical symptoms, patients with chronic kidney disease (CKD) exhibit elevated levels of pro-inflammatory markers. To investigate whether it is possible to detect inflammatory activity and altered monocyte function at an early stage of renal disease, we studied patients with CKD stages 2-3 over 5 years.Methods: The expression of adhesion molecules on monocytes at resting state and after stimulation with formyl-methionyl-leucyl-phenylalanine (fMLP), as well as oxidative metabolism capacity was measured with flow cytometry in 108 CKD patients and healthy controls. Soluble markers of inflamm...
Source: American Journal of Nephrology - September 7, 2016 Category: Neurology Source Type: research

Parathyroidectomy Increases Heart Rate Variability and Leptin Levels in Patients with Stage 5 Chronic Kidney Disease
Conclusion: Circulating leptin levels may be a novel treatment target to reduce CVD risk in advanced CKD-MBD patients.Am J Nephrol 2016;44:245-254 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study
Background: Stroke prevention in dialysis-dependent patients with atrial fibrillation (AF) is an unresolved clinical dilemma. Indeed, no randomized controlled trial evaluating the efficacy and safety of oral anticoagulants in this population, has been conducted so far. Observational research on the use of warfarin in patients on dialysis has shown conflicting results. This uncertainty is mirrored by the wide variations in warfarin prescription patterns across centers. We sought to evaluate the association between the use of vitamin K antagonists (VKAs) and mortality among hemodialysis patient with AF and to assess potentia...
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Oral Anticoagulation in End-Stage Renal Disease: Is It Time to Absolve Warfarin?
Am J Nephrol 2016;44:255-257 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study.
Abstract BACKGROUND: Stroke prevention in dialysis-dependent patients with atrial fibrillation (AF) is an unresolved clinical dilemma. Indeed, no randomized controlled trial evaluating the efficacy and safety of oral anticoagulants in this population, has been conducted so far. Observational research on the use of warfarin in patients on dialysis has shown conflicting results. This uncertainty is mirrored by the wide variations in warfarin prescription patterns across centers. We sought to evaluate the association between the use of vitamin K antagonists (VKAs) and mortality among hemodialysis patient with AF and ...
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Am J Nephrol Source Type: research