Corticosteroid for IgA Nephropathy: Are They Really Therapeutic?
Conclusion: This study provides the clear beneficial effects of the steroids therapy on the kidney function and proteinuria, although it should be used with caution.Am J Nephrol 2018;47:385 –394 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2018 Category: Neurology Source Type: research

Association of Monocyte Chemoattractant Protein-1 with Death and Atherosclerotic Events in Chronic Kidney Disease
Conclusions: Although plasma MCP-1 increased with decreased eGFR, it remained an independent risk factor for death in CKD. MCP-1 did not correlate with intermediate CV outcomes, implicating pathways other than atherosclerosis in the association of MCP-1 with death in CKD.Am J Nephrol 2018;47:395 –405 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2018 Category: Neurology Source Type: research

Ferric Citrate Decreases Fibroblast Growth Factor 23 and Improves Erythropoietin Responsiveness in Hemodialysis Patients
Conclusion: In patients on hemodialysis, 24-week treatment with ferric citrate hydrate resulted in significant reduction in FGF23 and ERI independently of serum phosphate level.Am J Nephrol 2018;47:406 –414 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2018 Category: Neurology Source Type: research

Corticosteroid for IgA Nephropathy: Are They Really Therapeutic?
Abstract BACKGROUND: IgA nephropathy (IgAN) is a common chronic glomerular disease that, in most patients, slowly progresses to end-stage kidney disease. The therapy with corticosteroid in IgAN is still a worldwide problem that is confusing the clinicians. METHODS: MEDLINE, EMBASE, the Cochrane Library, and article reference lists were searched for randomized controlled trials (RCTs) that compared corticosteroids with placebo and any other non-immunosuppressive agents in treating IgAN. Twelve RCTs involving 1,057 patients were included. RESULTS: Overall, we found that steroids had statistically significa...
Source: American Journal of Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Lin Y, Jia J, Guo Y, He D, Zhang Y, Wang F, Yan T, Liu Y, Lin S Tags: Am J Nephrol Source Type: research

Ferric Citrate Decreases Fibroblast Growth Factor 23 and Improves Erythropoietin Responsiveness in Hemodialysis Patients.
CONCLUSION: In patients on hemodialysis, 24-week treatment with ferric citrate hydrate resulted in significant reduction in FGF23 and ERI independently of serum phosphate level. PMID: 29874654 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Maruyama N, Otsuki T, Yoshida Y, Nagura C, Kitai M, Shibahara N, Tomita H, Maruyama T, Abe M Tags: Am J Nephrol Source Type: research

Association of Monocyte Chemoattractant Protein-1 with Death and Atherosclerotic Events in Chronic Kidney Disease.
Abstract BACKGROUND: Monocyte chemoattractant protein-1 -(MCP-1), a marker of inflammation and monocyte recruitment to atherosclerotic plaques, is associated with cardiovascular (CV) outcomes in patients with acute coronary syndrome. Although plasma levels are elevated in chronic kidney disease (CKD), associations with reduced kidney function or outcomes in CKD have not been explored. METHODS: In this population-based, probability-sampled, longitudinal cohort of 3,257 participants, including 286 (8.8%) patients with CKD, we studied the association of plasma MCP-1 with estimated glomerular filtration rate (eGF...
Source: American Journal of Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Gregg LP, Tio MC, Li X, Adams-Huet B, de Lemos JA, Hedayati SS Tags: Am J Nephrol Source Type: research

PRELIMS: Proteinuria in Nephrotic Syndrome: Mechanistic and Clinical Considerations in Optimizing Management.
Authors: PMID: 29860245 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 5, 2018 Category: Urology & Nephrology Tags: Am J Nephrol Source Type: research

PRELIMS: Proteinuria in Nephrotic Syndrome: Mechanistic and Clinical Considerations in Optimizing Management
Am J Nephrol 2018;47(suppl 1):I –IV (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2018 Category: Neurology Source Type: research

Proteinuria in Nephrotic Syndrome: Mechanistic and Clinical Considerations in Optimizing Management
Am J Nephrol 2018;47(suppl 1):1 –2 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 31, 2018 Category: Neurology Source Type: research

A Review of Podocyte Biology
Background: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte epithelial cells, including podocyte foot process effacement.Summary: Developments in imaging technology are improving knowledge of the detailed structure of the human renal glomerulus and cortex. Podocyte foot processes attach themselves to the glomerular capillaries at the glomerular basement membrane (GBM) forming i...
Source: American Journal of Nephrology - May 31, 2018 Category: Neurology Source Type: research

Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis
Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury demonstrated by renal biopsy that can arise from a diverse range of causes and mechanisms. It has an estimated incidence of 7 per 1 million and is the most common primary glomerular disorder leading to end-stage renal disease in the United States. This review focuses on damage to the podocyte and the consequences of this injury in patients with FSGS, the genetics of FSGS, and approaches to treatment with a focus on the effects on podocytes.Summary: The podocyte is central to the glomerular filtration barrier and is particularly vulnerab...
Source: American Journal of Nephrology - May 31, 2018 Category: Neurology Source Type: research

Membranous Nephropathy: Approaches to Treatment
Background: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. This review focuses on mechanisms involved in the pathogenesis of MN and approaches to treatment of this disease.Summary: Our understanding of the pathogenesis of primary MN has advanced greatly with the identification of M-type phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A as target antigens whose antibodies serve as biomarkers of this disease. Additional research, including investigations into the roles of complement and melanocortin receptors on the podocyte, may further improve our understanding of how ...
Source: American Journal of Nephrology - May 31, 2018 Category: Neurology Source Type: research

Immunoglobulin A Nephropathy: Advances in Understanding of Pathogenesis and Treatment
Background: Immunoglobulin A (IgA) nephropathy is the most common form of primary glomerulonephritis and has clinical associations with a wide range of inflammatory and infectious diseases. There is a substantial variation in clinical course and outcomes, with many patients not diagnosed until they present with sequelae, which may include gross hematuria, hypertension, renal insufficiency, and/or significant proteinuria. Treatment options are currently limited and directed mainly toward control of these sequelae and have limited ability to reduce the incidence of end-stage renal disease or treat the primary IgA defect.Summ...
Source: American Journal of Nephrology - May 31, 2018 Category: Neurology Source Type: research

Membranous Nephropathy: Approaches to Treatment.
Abstract BACKGROUND: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. This review focuses on mechanisms involved in the pathogenesis of MN and approaches to treatment of this disease. SUMMARY: Our understanding of the pathogenesis of primary MN has advanced greatly with the identification of M-type phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A as target antigens whose antibodies serve as biomarkers of this disease. Additional research, including investigations into the roles of complement and melanocortin receptors on the podocyte, may further improve o...
Source: American Journal of Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Bomback AS, Fervenza FC Tags: Am J Nephrol Source Type: research

A Review of Podocyte Biology.
Abstract BACKGROUND: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte epithelial cells, including podocyte foot process effacement. SUMMARY: Developments in imaging technology are improving knowledge of the detailed structure of the human renal glomerulus and cortex. Podocyte foot processes attach themselves to the glomerular capillaries at the glomerular basement ...
Source: American Journal of Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Garg P Tags: Am J Nephrol Source Type: research

Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis.
Abstract BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury demonstrated by renal biopsy that can arise from a diverse range of causes and mechanisms. It has an estimated incidence of 7 per 1 million and is the most common primary glomerular disorder leading to end-stage renal disease in the United States. This review focuses on damage to the podocyte and the consequences of this injury in patients with FSGS, the genetics of FSGS, and approaches to treatment with a focus on the effects on podocytes. SUMMARY: The podocyte is central to the glomerular filtration barrier and ...
Source: American Journal of Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Campbell KN, Tumlin JA Tags: Am J Nephrol Source Type: research

Proteinuria in Nephrotic Syndrome: Mechanistic and Clinical Considerations in Optimizing Management.
PMID: 29852500 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Tumlin JA, Campbell KN Tags: Am J Nephrol Source Type: research

Immunoglobulin A Nephropathy: Advances in Understanding of Pathogenesis and Treatment.
Abstract BACKGROUND: Immunoglobulin A (IgA) nephropathy is the most common form of primary glomerulonephritis and has clinical associations with a wide range of inflammatory and infectious diseases. There is a substantial variation in clinical course and outcomes, with many patients not diagnosed until they present with sequelae, which may include gross hematuria, hypertension, renal insufficiency, and/or significant proteinuria. Treatment options are currently limited and directed mainly toward control of these sequelae and have limited ability to reduce the incidence of end-stage renal disease or treat the prima...
Source: American Journal of Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Lafayette RA, Kelepouris E Tags: Am J Nephrol Source Type: research

Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease
We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2 –4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglobin-phosphate and bowel-kidney phosp...
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study
Conclusion: Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr  2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.Am J Nephrol 2018;47:304 –316 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study
Conclusion: This prospective study suggested that the intraperitoneal inflammation marker, dialysate IL-6 level, might be a potential predictor of peritonitis development in patients undergoing PD.Am J Nephrol 2018;47:317 –324 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Dietary Changes Involving < b > < i > Bifidobacterium < /i > < /b > < b > < i > longum < /i > < /b > and Other Nutrients Delays Chronic Kidney Disease Progression
Conclusion: Improving the gut environment using synbiotics ameliorated kidney function and might be a pharmacological treatment for SHPT without any serious adverse events.Am J Nephrol 2018;47:325 –332 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Association of Pre-End-Stage Renal Disease Hemoglobin with Early Dialysis Outcomes
Conclusions: Lower and higher pre-ESRD Hgb levels are associated with a higher risk of early post-ESRD mortality, while there was no association between the pre-ESRD slope and mortality. An increase in pre-ESRD Hgb slope was associated with higher risk of post-ESRD hospitalization. Additional studies aimed at anemia management prior to ESRD transition are warranted.Am J Nephrol 2018;47:333 –342 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Parathyroid Hormone, Fibroblast Growth Factor 23, and Parameters of Phosphate Reabsorption
Conclusions: Hyperbolas describe relationships of TRP/Ccr and TmP/GFR to [PTH] and [FGF23] if subjects with normal and reduced GFR are analyzed together. Although FEP rises with [PTH] and [FGF23] as GFR falls, the simultaneous increments do not signify hormonally mediated reductions in phosphate reabsorption.Am J Nephrol 2018;47:343 –351 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease
Conclusions: Results of this trial will provide important information on the feasibility, safety, and tolerability of long-term use of metformin in patients with ­ADPKD and provide preliminary information regarding its efficacy in slowing disease progression. Furthermore, results may support or refute the hypothesis that metformin effects on disease progression are mediated through the activation of the AMPK pathway. These results will be essential for the justification and design of a full-scale efficacy trial.Am J Nephrol 2018;47:352 –360 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction
Conclusions: Plasma H2S level decreased with the decline of eGFR, which may contribute to the cardiac dysfunction in CKD ­patients.Am J Nephrol 2018;47:361 –371 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Cortical or Trabecular Bone: What ’s the Difference?
Am J Nephrol 2018;47:373 –375 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation
Conclusions: Deterioration of cortical ­microarchitecture despite predominantly normal trabecular parameters reinforces the importance of comprehensive cortical evaluation in patients with CKD.Am J Nephrol 2018;47:376 –384 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2018 Category: Neurology Source Type: research

Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation.
CONCLUSIONS: Deterioration of cortical -microarchitecture despite predominantly normal trabecular parameters reinforces the importance of comprehensive cortical evaluation in patients with CKD. PMID: 29791896 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 23, 2018 Category: Urology & Nephrology Authors: Sharma AK, Toussaint ND, Masterson R, Holt SG, Rajapakse CS, Ebeling PR, Mohanty ST, Baldock P, Elder GJ Tags: Am J Nephrol Source Type: research

Cortical or Trabecular Bone: What's the Difference?
PMID: 29788030 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2018 Category: Urology & Nephrology Authors: Ott SM Tags: Am J Nephrol Source Type: research

Parathyroid Hormone, Fibroblast Growth Factor 23, and Parameters of Phosphate Reabsorption.
CONCLUSIONS: Hyperbolas describe relationships of TRP/Ccr and TmP/GFR to [PTH] and [FGF23] if subjects with normal and reduced GFR are analyzed together. Although FEP rises with [PTH] and [FGF23] as GFR falls, the simultaneous increments do not signify hormonally mediated reductions in phosphate reabsorption. PMID: 29779023 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Phelps KR, Mason DL Tags: Am J Nephrol Source Type: research

A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.
Abstract BACKGROUND: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD). METHODS: A phase II, double-blinded randomized placebo-controlled trial of 26 months duration. Participants will include nondiabetic adults (n = 96) aged 18-60 years, with an estimated glomerular filtration rate (eGFR) ≥50 mL/min/1.73 m2 and ADPKD, recruited from university-ba...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT Tags: Am J Nephrol Source Type: research

Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease.
Abstract We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglobin-phosphate and bowel-k...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Tabibzadeh N, Mentaverri R, Daroux M, Mesbah R, Delpierre A, Paul JG, Deken V, Massy ZA, Bataille P Tags: Am J Nephrol Source Type: research

Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus.
CONCLUSION: Urinary EV UMOD mRNA levels are progressively elevated from T2DM to DKD groups and correlate with widely used eGFR and ACR diagnostic criteria. An EV mRNA signature could identify DKD with greater than 90% sensitivity and 70% specificity. PMID: 29779026 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Yamamoto CM, Murakami T, Oakes ML, Mitsuhashi M, Kelly C, Henry RR, Sharma K Tags: Am J Nephrol Source Type: research

Association of Pre-End-Stage Renal Disease Hemoglobin with Early Dialysis Outcomes.
Abstract BACKGROUND: Incident hemodialysis patients have a high mortality risk within the first months after dialysis initiation. Pre-end-stage renal disease (ESRD) factors like anemia management may impact early post-ESRD outcomes. Therefore, we evaluated the impact of pre-ESRD hemoglobin (Hgb) and pre-ESRD Hgb slope on post-ESRD mortality and hospitalization outcomes. METHODS: The study included 31,472 veterans transitioning to ESRD. Using Cox and negative binomial regression models, we evaluated the association of pre-ESRD Hgb and Hgb slope with 12-month post-ESRD all-cause and cardiovascular mortality and...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Kleine CE, Soohoo M, Ranasinghe ON, Park C, Marroquin MV, Obi Y, Rhee CM, Moradi H, Kovesdy CP, Kalantar-Zadeh K, Streja E Tags: Am J Nephrol Source Type: research

Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression.
CONCLUSION: Improving the gut environment using synbiotics ameliorated kidney function and might be a pharmacological treatment for SHPT without any serious adverse events. PMID: 29779028 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Iwashita Y, Ohya M, Yashiro M, Sonou T, Kawakami K, Nakashima Y, Yano T, Iwashita Y, Mima T, Negi S, Kubo K, Tomoda K, Odamaki T, Shigematsu T Tags: Am J Nephrol Source Type: research

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction.
Abstract BACKGROUND: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. METHODS: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control. Plasma concentration of H2S was measured wi...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Kuang Q, Xue N, Chen J, Shen Z, Cui X, Fang Y, Ding X Tags: Am J Nephrol Source Type: research

High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study.
CONCLUSION: This prospective study suggested that the intraperitoneal inflammation marker, dialysate IL-6 level, might be a potential predictor of peritonitis development in patients undergoing PD. PMID: 29779030 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Yang X, Tong Y, Yan H, Ni Z, Qian J, Fang W Tags: Am J Nephrol Source Type: research

Kidney Disease in Women is Associated with Disadvantaged Childhood Socioeconomic Position.
Abstract BACKGROUND: Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. METHODS: Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years. We defined childhood and adulthood SEP according to father's and respondent's occupation respectively. SEP was categorised as hig...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Canney M, Leahy S, Scarlett S, Kenny RA, Little MA, O'Seaghdha CM, McCrory C Tags: Am J Nephrol Source Type: research

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study.
H, Arisawa K, Sasakabe T, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Wakai K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group Abstract BACKGROUND: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. METHODS: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data w...
Source: American Journal of Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Turin TC, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura Tags: Am J Nephrol Source Type: research

Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy
Conclusions: Serum SAA1 may be a candidate PMN biomarker that can be used to discriminate CNI NR cases from remission patients. The combination of SAA1 and the PLA2R antibody increases the accuracy of diagnosis.Am J Nephrol 2018;47:266 –274 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2018 Category: Neurology Source Type: research

Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure
Conclusions: Lower serum uromodulin, a possible indicator of less well-preserved renal tubular function, remained associated with greater risk for kidney allograft failure, after adjustment for major, established clinical kidney allograft failure and CVD risk factors, in a large, multiethnic cohort of long-term, stable KTRs.Am J Nephrol 2018;47:275 –282 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2018 Category: Neurology Source Type: research

Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy.
CONCLUSIONS: Serum SAA1 may be a candidate PMN biomarker that can be used to discriminate CNI NR cases from remission patients. The combination of SAA1 and the PLA2R antibody increases the accuracy of diagnosis. PMID: 29698936 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Authors: Yu X, Cai J, Jiao X, Zhang S, Liu H, Ding X Tags: Am J Nephrol Source Type: research

Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.
CONCLUSIONS: Lower serum uromodulin, a possible indicator of less well-preserved renal tubular function, remained associated with greater risk for kidney allograft failure, after adjustment for major, established clinical kidney allograft failure and CVD risk factors, in a large, multiethnic cohort of long-term, stable KTRs. PMID: 29698955 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Authors: Bostom A, Steubl D, Garimella PS, Franceschini N, Roberts MB, Pasch A, Ix JH, Tuttle KR, Ivanova A, Shireman T, Kim SJ, Gohh R, Weiner DE, Levey AS, Hsu CY, Kusek JW, Eaton CB Tags: Am J Nephrol Source Type: research

Obestatin, a Ghrelin-Cognate Protein, and Clinical Outcomes in Hemodialysis Patients
Am J Nephrol 2018;47:251 –253 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2018 Category: Neurology Source Type: research

Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients
Conclusion: Serum obestatin behaves as a biomarker for cardiovascular and all-cause mortality in MHD patients. The prognostic ability of obestatin in this regard is independent of inflammation, nutritional status, acyl-ghrelin ’s and adipokines’ activity and is modified by age being very prominent in patients older than 71 years.Am J Nephrol 2018;47:254 –265 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2018 Category: Neurology Source Type: research

Serum Obestatin: A Biomarker of Cardiovascular and All-Cause Mortality in Hemodialysis Patients.
CONCLUSION: Serum obestatin behaves as a biomarker for cardiovascular and all-cause mortality in MHD patients. The prognostic ability of obestatin in this regard is independent of inflammation, nutritional status, acyl-ghrelin's and adipokines' activity and is modified by age being very prominent in patients older than 71 years. PMID: 29694945 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2018 Category: Urology & Nephrology Authors: Beberashvili I, Katkov A, Sinuani I, Azar A, Shapiro G, Feldman L, Gorelik O, Stav K, Efrati S Tags: Am J Nephrol Source Type: research

Obestatin, a Ghrelin-Cognate Protein, and Clinical Outcomes in Hemodialysis Patients.
PMID: 29694953 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2018 Category: Urology & Nephrology Authors: Zoccali C, Mallamaci F Tags: Am J Nephrol Source Type: research

Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials
Conclusions: Markers of collagen turnover and changes in klotho levels are potential novel pathways associated with regression of LVH in the dialysis population, which will require further prospective validation.Am J Nephrol 2018;47:208 –217 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 5, 2018 Category: Neurology Source Type: research

Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline
Conclusion: Higher FGF-23 concentrations were not consistently associated with decline in kidney function or incident CKD in community-dwelling older adults.Am J Nephrol 2018;47:242 –250 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 5, 2018 Category: Neurology Source Type: research