Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research
Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research
Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research
Deliverables from Metabolomics in Kidney Disease: Adenine, New Insights and Implication for Clinical Decision Making
Am J Nephrol. 2024 Mar 3. doi: 10.1159/000538051. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression.SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative pote...
Source: American Journal of Nephrology - March 3, 2024 Category: Urology & Nephrology Authors: Nagarjunachary Ragi Kumar Sharma Source Type: research
Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research
Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research
Rilparencel (Renal Autologous Cell Therapy-REACT ®) for Chronic Kidney Disease and Type 1 and 2 Diabetes: Phase 2 Trial Design Evaluating Bilateral Kidney Dosing and Re-Dosing Triggers
CONCLUSION: This multicenter phase 2 RCT is designed to investigate the efficacy and safety of rilparencel with bilateral kidney dosing and comparing two injection schedules with the potential of preserving or improving kidney function and delaying kidney disease progression among patients with Stages 3a-4 CKD with diabetes.PMID:38423000 | DOI:10.1159/000537942 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 29, 2024 Category: Urology & Nephrology Authors: Joseph Stavas Arnold L Silva Thomas D Wooldridge Ahmed Aqeel Theodore Saad Rachita Prakash George Bakris Source Type: research
Expanding the Impact of SGLT2 Inhibitors in Chronic Kidney Disease
Am J Nephrol. 2024 Feb 28:1-4. doi: 10.1159/000536540. Online ahead of print.NO ABSTRACTPMID:38417403 | DOI:10.1159/000536540 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 28, 2024 Category: Urology & Nephrology Authors: Alaa T Makawi Yahya M K Tawfik Dave L Dixon Gearoid M McMahon Leo F Buckley Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
