Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation
Conclusions: The nuclear p16-staining rate in donated kidney tubules is a predictor for allograft kidney function but not donor remnant kidney function. Detection of tubular cell senescence may facilitate selection of appropriate living donor candidates.Am J Nephrol 2018;47:8 –17 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2017 Category: Neurology Source Type: research

Glycemic Control Assessment in the Dialysis Patient: Is Glycated Albumin the Answer?
Am J Nephrol 2018;47:18 –20 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2017 Category: Neurology Source Type: research

Experimental Inhibition of Periostin Attenuates Kidney Fibrosis
Conclusion: Periostin is a marker of renal fibrosis and may augment the progression of fibrogenesis as an extracellular matrix protein. Periostin blockade effectively attenuated renal fibrogenesis. Thus, periostin inhibition may be a therapeutic strategy for the amelioration of renal disease progression.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2017 Category: Neurology Source Type: research

Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation.
In this study, we assessed the association of tubular cell senescence with allograft and remnant kidney function by a prospective observational clinical study. METHODS: Thirty-eight living donor kidney transplantations were analyzed prospectively. Tissue sections obtained from preimplantation kidney biopsies were immunostained for p16INK4a to indicate cell senescence. Various kidney biomarkers were analyzed in urine and blood samples. RESULTS: Of the 38 donors, 21 had marginal factors. Severe tubular senescence was found in living donors with overlapping marginal criteria. Tubular senescence in living donor kidne...
Source: American Journal of Nephrology - December 22, 2017 Category: Urology & Nephrology Authors: Sofue T, Kushida Y, Ozaki T, Moritoki M, Nishijima Y, Ohsaki H, Ueda N, Kakehi Y, Nishiyama A, Minamino T Tags: Am J Nephrol Source Type: research

Glycemic Control Assessment in the Dialysis Patient: Is Glycated Albumin the Answer?
PMID: 29275401 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2017 Category: Urology & Nephrology Authors: Molitch ME Tags: Am J Nephrol Source Type: research

Comparison of Glycemic Markers in Chronic Hemodialysis Using Continuous Glucose Monitoring.
This study evaluated glycated albumin (GA) and glycated serum protein (GSP) as alternatives to HbA1c in detecting glycemic control among diabetic hemodialysis patients using continuous-glucose-monitoring (CGM)-derived glucose as reference standard. METHODS: A CGM system (iPRO) was applied for 7 days in 37 diabetic hemodialysis patients to determine glycemic control. The accuracy of GA and GSP versus HbA1c in detecting a 7-day average glucose ≥184 mg/dL was evaluated via receiver-operating-characteristic (ROC) analysis. RESULTS: CGM-derived glucose exhibited strong correlation (r = 0.970, p 20.3% had ...
Source: American Journal of Nephrology - December 22, 2017 Category: Urology & Nephrology Authors: Divani M, Georgianos PI, Didangelos T, Iliadis F, Makedou A, Hatzitolios A, Liakopoulos V, Grekas DM Tags: Am J Nephrol Source Type: research

Experimental Inhibition of Periostin Attenuates Kidney Fibrosis.
CONCLUSION: Periostin is a marker of renal fibrosis and may augment the progression of fibrogenesis as an extracellular matrix protein. Periostin blockade effectively attenuated renal fibrogenesis. Thus, periostin inhibition may be a therapeutic strategy for the amelioration of renal disease progression. PMID: 29268247 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 21, 2017 Category: Urology & Nephrology Authors: Hwang JH, Yang SH, Kim YC, Kim JH, An JN, Moon KC, Oh YK, Park JY, Kim DK, Kim YS, Lim CS, Lee JP Tags: Am J Nephrol Source Type: research

Periostin: The Missing Link to Attenuate Kidney Fibrosis
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 19, 2017 Category: Neurology Source Type: research

Racial/Ethnic Differences in Barriers to Kidney Transplant Evaluation among Hemodialysis Patients
Conclusion: Timely referral by providers and improved kidney transplantation education may reduce disparities in access to kidney transplantation.Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 19, 2017 Category: Neurology Source Type: research

Racial/Ethnic Differences in Barriers to Kidney Transplant Evaluation among Hemodialysis Patients.
CONCLUSION: Timely referral by providers and improved kidney transplantation education may reduce disparities in access to kidney transplantation. PMID: 29258094 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 19, 2017 Category: Urology & Nephrology Authors: Jones D, You Z, Kendrick JB Tags: Am J Nephrol Source Type: research

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus
Conclusions: In this largest-to-date randomized controlled trial in uremic pruritus, NAL 120 durably and significantly reduced the itching intensity among hemodialysis patients.Am J Nephrol 2017;46:450 –458 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 18, 2017 Category: Neurology Source Type: research

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus.
CONCLUSIONS: In this largest-to-date randomized controlled trial in uremic pruritus, NAL 120 durably and significantly reduced the itching intensity among hemodialysis patients. PMID: 29253847 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Mathur VS, Kumar J, Crawford PW, Hait H, Sciascia T, TR02 Study Investigators Tags: Am J Nephrol Source Type: research

Change in Hemoglobin Trajectory and Darbepoetin Dose Approaching End-Stage Renal Disease: Data from the Trial to Reduce Cardiovascular Events with Aranesp Therapy Trial
Conclusions: Our analyses provide descriptive insights regarding the temporal changes of Hb, darbepoetin dose, and related parameters as ESRD approaches in participants of TREAT. Hb declined as much as 1 –2 years prior to the development of ESRD, without biochemical evidence of iron deficiency. The most precipitous decline occurred in the months immediately prior to ESRD, despite administration of escalating doses of darbepoetin and in parallel with an increase in CRP.Am J Nephrol 2017;46:488 –497 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 14, 2017 Category: Neurology Source Type: research

Combination Cyclophosphamide/Glucocorticoids Provide Better Tolerability and Outcomes versus Glucocorticoids Alone in Patients with Sjogren ’s Associated Chronic Interstitial Nephritis
Conclusions: CTX therapy is suggested for primary Sjogren ’s syndrome patients with chronic TIN, especially those with higher IgG levels and abnormal renal function at baseline.Am J Nephrol 2017;46:473 –480 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 14, 2017 Category: Neurology Source Type: research

Change in Hemoglobin Trajectory and Darbepoetin Dose Approaching End-Stage Renal Disease: Data from the Trial to Reduce Cardiovascular Events with Aranesp Therapy Trial.
CONCLUSIONS: Our analyses provide descriptive insights regarding the temporal changes of Hb, darbepoetin dose, and related parameters as ESRD approaches in participants of TREAT. Hb declined as much as 1-2 years prior to the development of ESRD, without biochemical evidence of iron deficiency. The most precipitous decline occurred in the months immediately prior to ESRD, despite administration of escalating doses of darbepoetin and in parallel with an increase in CRP. PMID: 29241199 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 14, 2017 Category: Urology & Nephrology Authors: Mc Causland FR, Claggett B, Pfeffer MA, Burdmann EA, Eckardt KU, Levey AS, McMurray JJV, Remuzzi G, Singh AK, Solomon SD, Toto RD, Parfrey P Tags: Am J Nephrol Source Type: research

Combination Cyclophosphamide/Glucocorticoids Provide Better Tolerability and Outcomes versus Glucocorticoids Alone in Patients with Sjogren's Associated Chronic Interstitial Nephritis.
Abstract BACKGROUND: Steroid therapy has become an effective option for patients with primary Sjogren's syndrome with tubulointerstitial nephritis (TIN), while the use of cytotoxic agents is still debated. Our study aimed to compare the clinical outcomes of patients treated with cyclophosphamide (CTX) combined with glucocorticoids with those of patients treated with glucocorticoids alone. METHODS: All patients with primary Sjogren's syndrome with chronic TIN admitted to the Division of Nephrology, Ruijin Hospital, from January 1, 2002, to April 30, 2016, and treated with steroids alone or combined with CTX we...
Source: American Journal of Nephrology - December 14, 2017 Category: Urology & Nephrology Authors: Shen Y, Xie J, Lin L, Li X, Shen P, Pan X, Ren H, Chen N Tags: Am J Nephrol Source Type: research

The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics
Conclusion: CREDENCE will provide definitive evidence about the effects of canagliflozin on renal (and cardiovascular) outcomes in patients with type 2 diabetes and established kidney disease.Trial Registration: EudraCT number: 2013-004494-28; ClinicalTrials.gov identifier: NCT02065791. (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2017 Category: Neurology Source Type: research

Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis
Conclusion: In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.Am J Nephrol 2017;46:481 –487 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2017 Category: Neurology Source Type: research

Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis.
CONCLUSION: In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset. PMID: 29237149 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 13, 2017 Category: Urology & Nephrology Authors: Hughes-Austin JM, Gan RW, Deane KD, Weisman MH, Demoruelle MK, Sokolove J, Robinson WH, Holers VM, Norris JM, Ix JH Tags: Am J Nephrol Source Type: research

Will Canagliflozin Lend Credence to the Potential Effects of Sodium-Glucose Co-Transporter 2 Inhibitors on Renal Endpoints in Diabetic Nephropathy
Am J Nephrol 2017;46:459 –461 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 11, 2017 Category: Neurology Source Type: research

Will Canagliflozin Lend Credence to the Potential Effects of Sodium-Glucose Co-Transporter 2 Inhibitors on Renal Endpoints in Diabetic Nephropathy.
PMID: 29227973 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 11, 2017 Category: Urology & Nephrology Authors: Neumiller JJ, Rhee CM, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Uremic Pruritus: An Itch with Ominous Consequences
Am J Nephrol (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 28, 2017 Category: Neurology Source Type: research

Uremic Pruritus: An Itch with Ominous Consequences.
PMID: 29183013 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 28, 2017 Category: Urology & Nephrology Authors: Germain MJ Tags: Am J Nephrol Source Type: research

Interactive Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers or Their Combination on Survival of Hemodialysis Patients
Conclusion: Among hemodialysis patients with secondary hyperparathyroidism, unlike ACEI use, ARB use was associated with greater survival than non-use. Conversely, combination use was associated with greater mortality. Controlled trials are warranted to verify the causality factors of these associations.Am J Nephrol 2017;46:439 –447 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2017 Category: Neurology Source Type: research

Interactive Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers or Their Combination on Survival of Hemodialysis Patients.
CONCLUSION: Among hemodialysis patients with secondary hyperparathyroidism, unlike ACEI use, ARB use was associated with greater survival than non-use. Conversely, combination use was associated with greater mortality. Controlled trials are warranted to verify the causality factors of these associations. PMID: 29161689 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 21, 2017 Category: Urology & Nephrology Authors: Kido R, Akizawa T, Fukagawa M, Onishi Y, Yamaguchi T, Fukuhara S Tags: Am J Nephrol Source Type: research

Calciphylaxis: Another Piece of the Puzzle
Am J Nephrol 2017;46:427 –428 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 9, 2017 Category: Neurology Source Type: research

Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis
Conclusions: The BMP signal transduction pathway is activated in the cutaneous vasculature of calciphylaxis patients. The ability to detect p-SMAD 1/5/9, Id1, and Id3 in cutaneous vasculature may assist in the diagnosis of calciphylaxis. As BMP signaling inhibitors become available, this pathway may serve as a future therapeutic target for calciphylaxis.Am J Nephrol 2017;46:429 –438 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 9, 2017 Category: Neurology Source Type: research

Calciphylaxis: Another Piece of the Puzzle.
PMID: 29130965 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 9, 2017 Category: Urology & Nephrology Authors: Brandenburg VM, Sinha S Tags: Am J Nephrol Source Type: research

Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis.
CONCLUSIONS: The BMP signal transduction pathway is activated in the cutaneous vasculature of calciphylaxis patients. The ability to detect p-SMAD 1/5/9, Id1, and Id3 in cutaneous vasculature may assist in the diagnosis of calciphylaxis. As BMP signaling inhibitors become available, this pathway may serve as a future therapeutic target for calciphylaxis. PMID: 29130990 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 9, 2017 Category: Urology & Nephrology Authors: Nigwekar SU, Jiramongkolchai P, Wunderer F, Bloch E, Ichinose R, Nazarian RM, Thadhani RI, Malhotra R, Bloch DB Tags: Am J Nephrol Source Type: research

A Review of Anesthetic Effects on Renal Function: Potential Organ Protection
Background: Renal protection is a critical concept for anesthesiologists, nephrologists, and urologists, since anesthesia and renal function are highly interconnected and can potentially interfere with one another. Therefore, a comprehensive understanding of anesthetic drugs and their effects on renal function remains fundamental to the success of renal surgeries, especially transplant procedures. Some experimental studies have shown that some anesthetics provide protection against renal ischemia/reperfusion (IR) injury, but there is limited clinical evidence.Summary: The effects of anesthetic drugs on renal failure are pa...
Source: American Journal of Nephrology - November 7, 2017 Category: Neurology Source Type: research

Performance of the Surprise Question Compared to Prediction Models in Hemodialysis Patients: A Prospective Study
Conclusion: PMs exhibit superior sensitivity compared to the SQ for mortality prognostication in HD patients.Am J Nephrol 2017;46:390 –396 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Neurology Source Type: research

Pre-End-Stage Renal Disease Hemoglobin Variability Predicts Post-End-Stage Renal Disease Mortality in Patients Transitioning to Dialysis
Conclusions: High pre-ESRD Hb-var is associated with higher mortality, particularly from infectious causes rather than cardiovascular causes. Further research is required to clarify the underlying mechanisms and true causal nature of the observed association.Am J Nephrol 2017;46:397 –407 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Neurology Source Type: research

Lymphocyte Cell Ratios and Mortality among Incident Hemodialysis Patients
Conclusions: High NLR in incident hemodialysis patients predicted mortality, especially in the short-term period. NLR, but not PLR, added modest benefit in predicting mortality along with demographics, comorbidities, and serum albumin, and should be included in prognostication approaches.Am J Nephrol 2017;46:408 –416 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Neurology Source Type: research

Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study
Conclusion: Tolvaptan added to furosemide resulted in a greater diuretic effect than increased furosemide, even in normonatremia patients with CHF complicated by CKD stages G3b-5 in the very early treatment phase.Am J Nephrol 2017;46:417 –426 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Neurology Source Type: research

Performance of the Surprise Question Compared to Prediction Models in Hemodialysis Patients: A Prospective Study.
CONCLUSION: PMs exhibit superior sensitivity compared to the SQ for mortality prognostication in HD patients. PMID: 29130949 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Urology & Nephrology Authors: Malhotra R, Tao X, Wang Y, Chen Y, Apruzzese RH, Balter P, Xiao Q, Usvyat LA, Kotanko P, Thijssen S Tags: Am J Nephrol Source Type: research

Effects of Tolvaptan Addition to Furosemide in Normo- and Hyponatremia Patients with Heart Failure and Chronic Kidney Disease Stages G3b-5: A Subanalysis of the K-STAR Study.
CONCLUSION: Tolvaptan added to furosemide resulted in a greater diuretic effect than increased furosemide, even in normonatremia patients with CHF complicated by CKD stages G3b-5 in the very early treatment phase. PMID: 29130954 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Urology & Nephrology Authors: Tominaga N, Kida K, Inomata T, Sato N, Izumi T, Akashi YJ, Shibagaki Y Tags: Am J Nephrol Source Type: research

Lymphocyte Cell Ratios and Mortality among Incident Hemodialysis Patients.
CONCLUSIONS: High NLR in incident hemodialysis patients predicted mortality, especially in the short-term period. NLR, but not PLR, added modest benefit in predicting mortality along with demographics, comorbidities, and serum albumin, and should be included in prognostication approaches. PMID: 29130984 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Urology & Nephrology Authors: Catabay C, Obi Y, Streja E, Soohoo M, Park C, Rhee CM, Kovesdy CP, Hamano T, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Pre-End-Stage Renal Disease Hemoglobin Variability Predicts Post-End-Stage Renal Disease Mortality in Patients Transitioning to Dialysis.
CONCLUSIONS: High pre-ESRD Hb-var is associated with higher mortality, particularly from infectious causes rather than cardiovascular causes. Further research is required to clarify the underlying mechanisms and true causal nature of the observed association. PMID: 29130991 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2017 Category: Urology & Nephrology Authors: Sumida K, Diskin CD, Molnar MZ, Potukuchi PK, Thomas F, Lu JL, Rhee CM, Streja E, Yamagata K, Kalantar-Zadeh K, Kovesdy CP Tags: Am J Nephrol Source Type: research

A Review of Anesthetic Effects on Renal Function: Potential Organ Protection.
Abstract BACKGROUND: Renal protection is a critical concept for anesthesiologists, nephrologists, and urologists, since anesthesia and renal function are highly interconnected and can potentially interfere with one another. Therefore, a comprehensive understanding of anesthetic drugs and their effects on renal function remains fundamental to the success of renal surgeries, especially transplant procedures. Some experimental studies have shown that some anesthetics provide protection against renal ischemia/reperfusion (IR) injury, but there is limited clinical evidence. SUMMARY: The effects of anesthetic drugs...
Source: American Journal of Nephrology - November 7, 2017 Category: Urology & Nephrology Authors: Motayagheni N, Phan S, Eshraghi C, Nozari A, Atala A Tags: Am J Nephrol Source Type: research

A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease
Conclusions: SC HX575 in dialysis patients with renal anemia was therapeutically equivalent to the reference medicine in terms of maintaining stable Hb levels and safety.Am J Nephrol 2017;46:364 –370 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2017 Category: Neurology Source Type: research

A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease.
CONCLUSIONS: SC HX575 in dialysis patients with renal anemia was therapeutically equivalent to the reference medicine in terms of maintaining stable Hb levels and safety. PMID: 29084409 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2017 Category: Urology & Nephrology Authors: Weir MR, Pergola PE, Agarwal RL, Fink JC, Kopyt NP, Singh AK, Kumar J, Schmitt S, Schaffar G, Rudy A, McKay JP, Kanceva R Tags: Am J Nephrol Source Type: research

The Systemic Activation of Programmed Death 1-PD-L1 Axis Protects Systemic Lupus Erythematosus Model from Nephritis.
CONCLUSION: Our research demonstrated that the protective function of systemic activation of PD-1-PD-L1 axis with PD-L1-Ig attenuates the nephritis in SLE-prone mice, which facilitates us to understand the suppressive function of PD-1-PD-L1 axis in the pathogenesis and progress of the lupus nephritis, and to explore a possible effective therapeutic strategy to SLE. PMID: 29069649 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 26, 2017 Category: Urology & Nephrology Authors: Liao W, Zheng H, Wu S, Zhang Y, Wang W, Zhang Z, Zhou C, Wu H, Min J Tags: Am J Nephrol Source Type: research

Association of Serum Amyloid A with Kidney Outcomes and All-Cause Mortality in American Indians with Type 2 Diabetes
Conclusions: Higher circulating SAA concentration is associated with a reduced risk of ESRD in American Indians with type 2 diabetes.Am J Nephrol 2017;46:276-284 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

Online Hemodiafiltration Improves Outcomes in Incident Patients with End-Stage Renal Disease: Another Brick in the Wall?
Am J Nephrol 2017;46:285 –287 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature
Background: The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance.Summary: The mechanism for MR activation in tissu...
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway
Conclusions: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF- κB signaling pathway, and the targeted intervention of the TLR4/NF-κB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT.Am J Nephrol 2017;46:333 –342 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

Effectiveness of IHD with Adsorptive PMMA Membrane in Myeloma Cast Nephropathy: A Cohort Study
Conclusion: In patients with dialysis-dependent myeloma cast nephropathy, early FLC removal by IHD-PMMA combined with chemotherapy was associated with high rates of renal recovery and survival.Am J Nephrol 2017;46:355 –363 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

Patiromer Lowers Serum Potassium When Taken < b > < i > without Food < /i > < /b > : Comparison to Dosing < b > < i > with Food < /i > < /b > from an Open-Label, Randomized, Parallel Group Hyperkalemia Study
Background: Patiromer is a sodium-free, nonabsorbed, potassium binder approved for treatment of hyperkalemia. This open-label study compares the efficacy and safety of patiromer administeredwithout food versuswith food.Methods: Adults with hyperkalemia (potassium ≥5.0 mEq/L) were randomized (1:1) to receive patiromer once dailywithout food orwith food for 4 weeks. The dosage was adjusted (maximum: 25.2 g/day) using a prespecified titration schedule to achieve and maintain potassium within a target range (3.8-5.0 mEq/L). The primary efficacy endpoint was the proportion of patients with serum potassium in the target range...
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

Venous Thromboembolism and the Risk of Death and Graft Loss in Kidney Transplant Recipients
Background: The implications of venous thromboembolism (VTE) for morbidity and mortality in kidney transplant recipients are not well described.Methods: We conducted a retrospective study using linked healthcare databases in Ontario, Canada to determine the risk and complications of VTE in kidney transplant recipients from 2003 to 2013. We compared the incidence rate of VTE in recipients (n = 4,343) and a matched (1:4) sample of the general population (n = 17,372). For recipients with evidence of a VTE posttransplant, we compared adverse clinical outcomes (death, graft loss) to matched (1:2) recipients without evidence of ...
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research

Impact of Uric Acid Levels on Kidney Disease Progression
Conclusions: Hyperuricemia is associated with increased risk of progression to ESRD in patients with CKD stages 3 and 4, but UALT does not ameliorate the risk, suggesting that the relationship is not causal.Am J Nephrol 2017;46:315 –322 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 25, 2017 Category: Neurology Source Type: research