Autosomal Dominant Polycystic Kidney Disease: Clinical Assessment of Rapid Progression
Conclusions: The ERA-EDTA WGIKD/ERBP algorithm provides a valuable means of identifying in routine clinical practice patients who may be eligible for treatment with tolvaptan. The impact of a new threshold for age and eGFR may increase the percentage of patients to be treated.Am J Nephrol 2018;48:308 –317 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Changing Trends in the Performance of Percutaneous Renal Biopsy from Nephrologist to Interventional Radiologist: A Single-Center Experience
Conclusion: We find that there has been a significant transition over time in the performance of PRB by a nephrologist to IR. The major reason for this is the time burden associated with PRB and the availability of IRs.Am J Nephrol 2018;48:326 –329 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2018 Category: Neurology Source Type: research

Changing Trends in the Performance of Percutaneous Renal Biopsy from Nephrologist to Interventional Radiologist: A Single-Center Experience.
Abstract BACKGROUND: Percutaneous renal biopsy of native kidneys (PRB) has been an integral part of the practice of nephrology. However, over the past 30 years, PRB has transitioned from a procedure performed only by nephrologists to interventional radiologists (IRs). We surveyed practicing nephrologists completing training in our program to determine the clinical practice patterns of PRB. METHODS: The 78 fellows completing the nephrology program at Rush University Medical Center from June 1984 through June 2017 were successfully contacted and surveyed regarding their opinion on adequacy of their training and...
Source: American Journal of Nephrology - October 24, 2018 Category: Urology & Nephrology Authors: Korbet SM, Whittier WL, Rodby RA Tags: Am J Nephrol Source Type: research

Polycystic Kidney Disease Progression: Learning from Europe.
PMID: 30347387 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Cowley BD Tags: Am J Nephrol Source Type: research

Meet the Twins: Intradialytic and Interdialytic Hypertension.
PMID: 30347388 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Georgianos PI, Agarwal R Tags: Am J Nephrol Source Type: research

Autosomal Dominant Polycystic Kidney Disease: Clinical Assessment of Rapid Progression.
CONCLUSIONS: The ERA-EDTA WGIKD/ERBP algorithm provides a valuable means of identifying in routine clinical practice patients who may be eligible for treatment with tolvaptan. The impact of a new threshold for age and eGFR may increase the percentage of patients to be treated. PMID: 30347391 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Furlano M, Loscos I, Martí T, Bullich G, Ayasreh N, Rius A, Roca L, Ballarín J, Ars E, Torra R Tags: Am J Nephrol Source Type: research

A Comparative Study of Short-Term Blood Pressure Variability in Hemodialysis Patients with and without Intradialytic Hypertension.
CONCLUSIONS: BPV is similar between those with and without intradialytic hypertension. However, those with intradialytic hypertension have a sustained increase in systolic and diastolic BP during the entire interdialytic interval. PMID: 30347395 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 22, 2018 Category: Urology & Nephrology Authors: Bikos A, Angeloudi E, Memmos E, Loutradis C, Karpetas A, Ginikopoulou E, Panagoutsos S, Pasadakis P, Liakopoulos V, Papagianni A, Sarafidis P Tags: Am J Nephrol Source Type: research

Gastrointestinal Disorders in Peritoneal Dialysis Patients
Background: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies.Summary: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or adhesions and abdominal ...
Source: American Journal of Nephrology - October 19, 2018 Category: Neurology Source Type: research

Gastrointestinal Disorders in Peritoneal Dialysis Patients.
Abstract BACKGROUND: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies. SUMMARY: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or ...
Source: American Journal of Nephrology - October 19, 2018 Category: Urology & Nephrology Authors: Kosmadakis G, Albaret J, da Costa Correia E, Somda F, Aguilera D Tags: Am J Nephrol Source Type: research

Age-Related Macular Degeneration in Chronic Kidney Disease: A Meta-Analysis of Observational Studies
Conclusions: The overall results support a positive association between CKD and AMD, although some limitations exist. Given the risk that AMD is increased in CKD, regular eye screenings for the CKD population is recommended for an early detection and intervention.Am J Nephrol 2018;48:278 –291 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 18, 2018 Category: Neurology Source Type: research

Age-Related Macular Degeneration in Chronic Kidney Disease: A Meta-Analysis of Observational Studies.
CONCLUSIONS: The overall results support a positive association between CKD and AMD, although some limitations exist. Given the risk that AMD is increased in CKD, regular eye screenings for the CKD population is recommended for an early detection and intervention. PMID: 30336463 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 18, 2018 Category: Urology & Nephrology Authors: Chen YJ, Yeung L, Sun CC, Huang CC, Chen KS, Lu YH Tags: Am J Nephrol Source Type: research

Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients
Conclusion: This study provides evidence for alterations in gut-microbiota-derived SCFAs with advancing CKD, demonstrates the association of higher plasma valerate levels with pre-existing CVD, and reveals areas for future exploration of  cardiovascular risk in patients with CKD.Am J Nephrol 2018;48:269 –277 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 16, 2018 Category: Neurology Source Type: research

Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients.
This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD. METHODS: SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD were randomly assigned to training and validation subsets. The primary outcome was a history of CAD and the secondary outcome was a composite history of cardiovascular disea...
Source: American Journal of Nephrology - October 16, 2018 Category: Urology & Nephrology Authors: Jadoon A, Mathew AV, Byun J, Gadegbeku CA, Gipson DS, Afshinnia F, Pennathur S, for the Michigan Kidney Translational Core CPROBE Investigator Group Tags: Am J Nephrol Source Type: research

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data
Conclusions: PIVOTAL will provide important information about the optimum dosing of IV iron in HD patients representative of usual clinical practice.Trial Registration: EudraCT number: 2013-002267-25.Am J Nephrol 2018;48:260 –268 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 10, 2018 Category: Neurology Source Type: research

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data.
rial investigators Abstract BACKGROUND: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. METHODS: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin
Source: American Journal of Nephrology - October 10, 2018 Category: Urology & Nephrology Authors: Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Steenkamp R, Tomson CRV, Wheeler DC, Winearls CG, Ford I, on behalf of the PIVOTAL Trial investigators Tags: Am J Nephrol Source Type: research

Comparing Therapeutic Efficacy and Safety of Epoetin Beta and Epoetin Alfa in the Treatment of Anemia in End-Stage Renal Disease Hemodialysis Patients
Conclusion: CinnaPoietin ® was proved to be non-inferior to Eprex® in the treatment of anemia in ESRD hemodialysis patients. The trial was registered in Clinicaltrials.gov (NCT03408639).Am J Nephrol 2018;48:251 –259 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 5, 2018 Category: Neurology Source Type: research

Comparing Therapeutic Efficacy and Safety of Epoetin Beta and Epoetin Alfa in the Treatment of Anemia in End-Stage Renal Disease Hemodialysis Patients.
CONCLUSION: CinnaPoietin® was proved to be non-inferior to Eprex® in the treatment of anemia in ESRD hemodialysis patients. The trial was registered in Clinicaltrials.gov (NCT03408639). PMID: 30253403 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2018 Category: Urology & Nephrology Authors: Azmandian J, Abbasi MR, Pourfarziani V, Nasiri AA, Ossareh S, Ezzatzadegan Jahromi S, Sanadgol H, Amini S, Shahvaroughi Farahani A Tags: Am J Nephrol Source Type: research

Cardiac Troponin T Risk Stratification Model Predicts All-Cause Mortality Following Kidney Transplant
Conclusions: We developed a risk schema predictive of all-cause mortality after kidney transplant in a derivation cohort. The ACTV score, including an elevated cTnT, provided superior prediction compared to a scoring system without cTnT. Further studies to validate these findings are needed.Am J Nephrol 2018;48:242 –250 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2018 Category: Neurology Source Type: research

Cardiac Troponin T Risk Stratification Model Predicts All-Cause Mortality Following Kidney Transplant.
CONCLUSIONS: We developed a risk schema predictive of all-cause mortality after kidney transplant in a derivation cohort. The ACTV score, including an elevated cTnT, provided superior prediction compared to a scoring system without cTnT. Further studies to validate these findings are needed. PMID: 30235441 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2018 Category: Urology & Nephrology Authors: Firth C, Shamoun F, Cha S, Zhang N, Patel S, Wennberg P, Amer H, Wadei H, Heilman R, Keddis M Tags: Am J Nephrol Source Type: research

Early Hospital Readmission in Older and Younger Kidney Transplant Recipients
Conclusions: Older KT recipients are more likely to experience EHR and are at a higher risk of graft loss after EHR than younger recipients. Targeted interventions to prevent EHR and subsequent graft loss in this population should be identified.Am J Nephrol 2018;48:235 –241 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 18, 2018 Category: Neurology Source Type: research

Early Hospital Readmission in Older and Younger Kidney Transplant Recipients.
Abstract BACKGROUND: Up to 31% of kidney transplant (KT) recipients experience early hospital readmission (EHR). We hypothesized that EHR among older KT recipients is higher than younger recipients due to increased comorbidities and higher prevalence of frailty. METHODS: We identified 22,458 older (age ≥65) and 86,372 younger (18 to
Source: American Journal of Nephrology - September 18, 2018 Category: Urology & Nephrology Authors: Haugen CE, King EA, Bae S, Bowring MG, Holscher CM, Garonzik-Wang J, McAdams-DeMarco M, Segev DL Tags: Am J Nephrol Source Type: research

Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury
Conclusion: Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance.Am J Nephrol 2018;48:225 –233 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 11, 2018 Category: Neurology Source Type: research

Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury.
CONCLUSION: Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance. PMID: 30205388 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 11, 2018 Category: Urology & Nephrology Authors: Cao M, Leite BN, Ferreiro T, Calvo M, Fernández C, Alonso Á, Rodriguez A, Salvador P, Seijo R, Pita S, Arjona E, Rodríguez de Córdoba S, Valdés Cañedo F Tags: Am J Nephrol Source Type: research

Novel Compound Induces Erythropoietin Secretion through Liver Effects in Chronic Kidney Disease Patients and Healthy Volunteers
Conclusions: TP0463518 induced dose-dependent EPO production, mainly derived from the liver in HV and CKD patients. These results suggest that TP0463518 is a new strategy for treating anemia in CKD, which can be used regardless of renal functions.Am J Nephrol 2018;48:157 –164 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

A New Treatment for Calciphylaxis in Hemodialysis Patients?
Am J Nephrol 2018;48:165 –167 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require Anticoagulation: A Retrospective Analysis
Calciphylaxis is a disease of dermal arteriolar calcification that results in necrosis. It commonly occurs in individuals with end-stage renal disease (ESRD) on hemodialysis and is associated with a high morbidity and mortality. Warfarin use is an identified risk factor. Twenty patients with ESRD on dialysis with calciphylaxis who were treated with apixaban for indications of deep vein thrombosis or atrial fibrillation were identified. There were no reports of thrombosis. Three individuals experienced bleeding requiring a transfusion, and anticoagulation was resumed without further event. Findings suggest that apixaban may...
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study
Conclusion: AMBER will define the ability of patiromer to facilitate the use of spironolactone, an effective antihypertensive therapy for patients with RHTN and CKD.Am J Nephrol 2018;48:172 –180 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients
Conclusions: Hemodialysis patients with more active intradialytic activities report better mental and kidney-disease-specific HRQOL. These results should be confirmed in a prospective study with a broader cohort of hemodialysis patients. Dialysis providers may consider offering patients with low levels of activity additional support and opportunities to engage in beneficial intradialytic activities.Am J Nephrol 2018;48:181 –189 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Have We Made “Rapid Progress” Understanding the Pathogenesis in Rapidly Progressive Glomerulonephritis?
Am J Nephrol 2018;48:190 –192 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

< b > < i > PYCARD < /i > < /b > Gene Plays a Key Role in Rapidly Progressive Glomerulonephritis: Results of a Weighted Gene Co-Expression Network Analysis
Conclusions: WGCNA in RPGN expression profiling was used for the first time in this paper. A novel hub gene closely associated with RPGN was screened out, thereby providing the brand-new molecular candidate for RPGN.Am J Nephrol 2018;48:193 –204 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Prognostic Significance of Asymptomatic Brain Natriuretic Peptide Elevation at Nephrology Referral in Patients with Chronic Kidney Disease
Conclusion: Asymptomatic elevation of BNP is strongly predictive for CVEs and HF, which might help to integrate cardio-renal risk stratification in predialysis CKD patients.Am J Nephrol 2018;48:205 –213 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Switching from Epoetin Alfa (Epogen ®) to Epoetin Alfa-Epbx (Retacrit < sup > TM < /sup > ) Using a Specified Dosing Algorithm: A Randomized, Non-Inferiority Study in Adults on Hemodialysis
Conclusions: Switching to RetacritTM was non-inferior to continuing ­Epogen® in maintaining hemoglobin levels in patients receiving hemodialysis, when both ESAs were dosed using a specified algorithm (ClinicalTrials.gov, NCT02504294).Am J Nephrol 2018;48:214 –224 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Neurology Source Type: research

Switching from Epoetin Alfa (Epogen ®) to Epoetin Alfa-Epbx (RetacritTM) Using a Specified Dosing Algorithm: A Randomized, Non-Inferiority Study in Adults on Hemodialysis.
CONCLUSIONS: Switching to RetacritTM was non-inferior to continuing -Epogen® in maintaining hemoglobin levels in patients receiving hemodialysis, when both ESAs were dosed using a specified algorithm (ClinicalTrials.gov, NCT02504294). PMID: 30196301 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Authors: Thadhani R, Guilatco R, Hymes J, Maddux FW, Ahuja A Tags: Am J Nephrol Source Type: research

Prognostic Significance of Asymptomatic Brain Natriuretic Peptide Elevation at Nephrology Referral in Patients with Chronic Kidney Disease.
CONCLUSION: Asymptomatic elevation of BNP is strongly predictive for CVEs and HF, which might help to integrate cardio-renal risk stratification in predialysis CKD patients. PMID: 30196305 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Authors: Hayashi T, Yasuda K, Kimura T, Sasaki K, Shimada K, Hashimoto N, Isaka Y Tags: Am J Nephrol Source Type: research

PYCARD Gene Plays a Key Role in Rapidly Progressive Glomerulonephritis: Results of a Weighted Gene Co-Expression Network Analysis.
CONCLUSIONS: WGCNA in RPGN expression profiling was used for the first time in this paper. A novel hub gene closely associated with RPGN was screened out, thereby providing the brand-new molecular candidate for RPGN. PMID: 30189426 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2018 Category: Urology & Nephrology Authors: Wang Z, Chen X, Zhang D, Cao Y, Zhang L, Tang W Tags: Am J Nephrol Source Type: research

Have We Made "Rapid Progress" Understanding the Pathogenesis in Rapidly Progressive Glomerulonephritis?
Have We Made "Rapid Progress" Understanding the Pathogenesis in Rapidly Progressive Glomerulonephritis? Am J Nephrol. 2018 Sep 05;48(3):190-192 Authors: Palmer ND, Ma L, Freedman BI PMID: 30184521 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2018 Category: Urology & Nephrology Authors: Palmer ND, Ma L, Freedman BI Tags: Am J Nephrol Source Type: research

Novel Compound Induces Erythropoietin Secretion through Liver Effects in Chronic Kidney Disease Patients and Healthy Volunteers.
CONCLUSIONS: TP0463518 induced dose-dependent EPO production, mainly derived from the liver in HV and CKD patients. These results suggest that TP0463518 is a new strategy for treating anemia in CKD, which can be used regardless of renal functions. PMID: 30176654 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2018 Category: Urology & Nephrology Authors: Shinfuku A, Shimazaki T, Fujiwara M, Sato F, Watase H, Numazaki T, Kawakita Y, Mutoh M, Yamasaki H, Takayama N, Kato S, Sugimoto T, Maruyama J Tags: Am J Nephrol Source Type: research

A New Treatment for Calciphylaxis in Hemodialysis Patients?
PMID: 30176667 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2018 Category: Urology & Nephrology Authors: Zoccali C, Mallamaci F Tags: Am J Nephrol Source Type: research

Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients.
CONCLUSIONS: Hemodialysis patients with more active intradialytic activities report better mental and kidney-disease-specific HRQOL. These results should be confirmed in a prospective study with a broader cohort of hemodialysis patients. Dialysis providers may consider offering patients with low levels of activity additional support and opportunities to engage in beneficial intradialytic activities. PMID: 30176670 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2018 Category: Urology & Nephrology Authors: Warsame F, Ying H, Haugen CE, Thomas AG, Crews DC, Shafi T, Jaar B, Chu NM, Segev DL, McAdams-DeMarco MA Tags: Am J Nephrol Source Type: research

Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study.
CONCLUSION: AMBER will define the ability of patiromer to facilitate the use of spironolactone, an effective antihypertensive therapy for patients with RHTN and CKD. PMID: 30176673 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 3, 2018 Category: Urology & Nephrology Authors: Agarwal R, Rossignol P, Garza D, Mayo MR, Warren S, Arthur S, Romero A, White WB, Williams B Tags: Am J Nephrol Source Type: research

The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require Anticoagulation: A Retrospective Analysis.
Abstract Calciphylaxis is a disease of dermal arteriolar calcification that results in necrosis. It commonly occurs in individuals with end-stage renal disease (ESRD) on hemodialysis and is associated with a high morbidity and mortality. Warfarin use is an identified risk factor. Twenty patients with ESRD on dialysis with calciphylaxis who were treated with apixaban for indications of deep vein thrombosis or atrial fibrillation were identified. There were no reports of thrombosis. Three individuals experienced bleeding requiring a transfusion, and anticoagulation was resumed without further event. Findings suggest...
Source: American Journal of Nephrology - September 3, 2018 Category: Urology & Nephrology Authors: Garza-Mayers AC, Shah R, Sykes DB, Nigwekar SU, Kroshinsky D Tags: Am J Nephrol Source Type: research

When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies
The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effective, eculizumab is costly and inconvenient. In this review, we evaluate the literature on eculizumab cessation in these diseases to better inform clinicians who consider stopping therapy. Reported relapse rates in aHUS after stopping eculizumab are as high as 30%, suggesting indefinite therapy is reasonable an...
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Serum Creatinine and Chronic Kidney Disease-Epidemiology Estimated Glomerular Filtration Rate: Independent Predictors of Renal Replacement Therapy following Cardiac Surgery
Conclusion: Preoperative renal function, defined by serum creatinine or eGFR by CKD-EPI, NYHA class II –IV, and the number of blood units transfused were all independent predictors of RRT postoperatively.Am J Nephrol 2018;48:108 –117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Changes in Total Protein Concentration Due to Fluid Removal During and Shortly after Hemodialysis
Conclusions: On average, after equilibration, the change in plasma volume due to fluid removal is similar to the modeled change in total body water (urea space), irrespective of dialysate to serum sodium gradient. This supports previous observations that during dialysis with ultrafiltration, plasma volume contracts to a lesser degree than the interstitial volume and that some fluid may be removed from spaces other than the extracellular fluid.Am J Nephrol 2018;48:118 –126 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Uric Acid as a Predictor of Immunoglobulin A Nephropathy Progression: A Cohort Study of 1965 Cases
Conclusions: SUA level may be positively associated with the progression of IgAN. It was noticeable that the association of hyperuricemia with IgAN progression was less significant in patients with elder age, lower eGFR, or tubular atrophy/interstitial fibrosis, which may be due to some more confounders in association with the IgA progression in these patients. Future prospective studies are warranted to confirm these findings and to investigate the underlying mechanisms.Am J Nephrol 2018;48:127 –136 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Clinic-Pathologic Features and Renal Outcome of Fabry Disease: Data from a Chinese Cohort
Conclusions: FD ’s clinical manifestations are heterogeneous and nonspecific. The ­10-year cumulative renal survival rate was low in Chinese patients. MSSI score and segmental sclerosis levels predict the renal prognosis of patients with FD sensitively.Am J Nephrol 2018;48:137 –146 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Obstructive Sleep Apnea Increases Sudden Cardiac Death in Incident Hemodialysis Patients
Conclusions: Incident hemodialysis patients with OSA are at increased risk of all-cause and cardiovascular mortality and SCD. Future studies should assess the impact of screening for OSA and OSA-targeted interventions on mortality in ESRD.Am J Nephrol 2018;48:147 –156 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

When to Stop Eculizumab in Complement-Mediated Thrombotic Microangiopathies.
Abstract The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effective, eculizumab is costly and inconvenient. In this review, we evaluate the literature on eculizumab cessation in these diseases to better inform clinicians who consider stopping therapy. Reported relapse rates in aHUS after stopping eculizumab are as high as 30%, suggesting indefinite therap...
Source: American Journal of Nephrology - August 15, 2018 Category: Urology & Nephrology Authors: Olson SR, Lu E, Sulpizio E, Shatzel JJ, Rueda JF, DeLoughery TG Tags: Am J Nephrol Source Type: research

Changes in Total Protein Concentration Due to Fluid Removal During and Shortly after Hemodialysis.
CONCLUSIONS: On average, after equilibration, the change in plasma volume due to fluid removal is similar to the modeled change in total body water (urea space), irrespective of dialysate to serum sodium gradient. This supports previous observations that during dialysis with ultrafiltration, plasma volume contracts to a lesser degree than the interstitial volume and that some fluid may be removed from spaces other than the extracellular fluid. PMID: 30110671 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Urology & Nephrology Authors: Daugirdas JT Tags: Am J Nephrol Source Type: research

Clinic-Pathologic Features and Renal Outcome of Fabry Disease: Data from a Chinese Cohort.
CONCLUSIONS: FD's clinical manifestations are heterogeneous and nonspecific. The -10-year cumulative renal survival rate was low in Chinese patients. MSSI score and segmental sclerosis levels predict the renal prognosis of patients with FD sensitively. PMID: 30110672 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Urology & Nephrology Authors: Zhang D, Zhang J, Liang S, Wang J, Liu Z Tags: Am J Nephrol Source Type: research