Thiazide-Associated Hyponatremia, Report of the Hyponatremia Registry: An Observational Multicenter International Study.
CONCLUSIONS: Despite its high incidence and potential risks, the management of TAH is often poor. Immediate withdrawal of the thiazide is crucial for treatment success. Hypertonic saline is most effective in correcting hyponatremia but associated with a high rate of overly rapid correction. We could not establish a diagnostic laboratory-based test to differentiate TIH from SIADH. PMID: 28419981 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 19, 2017 Category: Urology & Nephrology Authors: Burst V, Grundmann F, Kubacki T, Greenberg A, Becker I, Rudolf D, Verbalis J Tags: Am J Nephrol Source Type: research

Thiazide-Associated Hyponatremia: A Major Dilemma Affecting Treatment.
PMID: 28420005 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 19, 2017 Category: Urology & Nephrology Authors: Palmer BF, Clegg DJ Tags: Am J Nephrol Source Type: research

Thiazide-Associated Hyponatremia, Report of the Hyponatremia Registry: An Observational Multicenter International Study
Conclusions: Despite its high incidence and potential risks, the management of TAH is often poor. Immediate withdrawal of the thiazide is crucial for treatment success. Hypertonic saline is most effective in correcting hyponatremia but associated with a high rate of overly rapid correction. We could not establish a diagnostic laboratory-based test to differentiate TIH from SIADH.Am J Nephrol 2017;45:420-430 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 18, 2017 Category: Neurology Source Type: research

Thiazide-Associated Hyponatremia: A Major Dilemma Affecting Treatment
Am J Nephrol 2017;45:417-419 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 18, 2017 Category: Neurology Source Type: research

Psychosocial Factors and 30-Day Hospital Readmission among Individuals Receiving Maintenance Dialysis: A Prospective Study.
CONCLUSION: Poor social support and depressive symptoms identified during hospitalizations may represent targetable readmission risk factors among dialysis patients. Our findings suggest that hospital-based assessments of select psychosocial factors may improve readmission risk prediction. PMID: 28407633 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 14, 2017 Category: Urology & Nephrology Authors: Flythe JE, Hilbert J, Kshirsagar AV, Gilet CA Tags: Am J Nephrol Source Type: research

Pneumatic Compression, But Not Exercise, Can Avoid Intradialytic Hypotension: A Randomized Trial.
CONCLUSION: Pneumatic compression during the first hour of dialysis was associated with less DIH, albeit there was no effect on fluid parameters. Neither exercise nor pneumatic compression increased phosphate removal. PMID: 28407637 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 14, 2017 Category: Urology & Nephrology Authors: Álvares VR, Ramos CD, Pereira BJ, Pinto AL, Moysés RM, Gualano B, Elias RM Tags: Am J Nephrol Source Type: research

Pneumatic Compression, But Not Exercise, Can Avoid Intradialytic Hypotension: A Randomized Trial
Conclusion: Pneumatic compression during the first hour of dialysis was associated with less DIH, albeit there was no effect on fluid parameters. Neither exercise nor pneumatic compression increased phosphate removal.Am J Nephrol 2017;45:409-416 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2017 Category: Neurology Source Type: research

Psychosocial Factors and 30-Day Hospital Readmission among Individuals Receiving Maintenance Dialysis: A Prospective Study
Conclusion: Poor social support and depressive symptoms identified during hospitalizations may represent targetable readmission risk factors among dialysis patients. Our findings suggest that hospital-based assessments of select psychosocial factors may improve readmission risk prediction.Am J Nephrol 2017;45:400-408 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 13, 2017 Category: Neurology Source Type: research

Cardiac Troponins in Chronic Kidney Disease: A Marker of Global Cardiovascular Risk.
PMID: 28376487 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 5, 2017 Category: Urology & Nephrology Authors: Vaduganathan M, Bhatt DL Tags: Am J Nephrol Source Type: research

Superagonistic CD28 Protects against Renal Ischemic Injury by Expansion of Regulatory T-Cell
This study aims to test the protection and discover the mechanisms of CD28sa treatment against renal ischemia-reperfusion (IR) injury (IRI).Methods: Male C57BL/6N mice were treated with CD28sa via peritoneal injection (0.1 mg) 6 days before the induction of IRI, or with 18-min ischemic precondition (IPC). IRI was induced by bilateral clamping of renal pedicles for 35 min followed by reperfusion. The role of Treg expansion in renal protection conferred by CD28sa treatment was examined using anti-CD25 antibody.Results: CD28sa treatment alone significantly increased the percentage of Treg cells in the spleen (18.10 ± 2...
Source: American Journal of Nephrology - March 29, 2017 Category: Neurology Source Type: research

Superagonistic CD28 Protects against Renal Ischemic Injury by Expansion of Regulatory T-Cell.
This study aims to test the protection and discover the mechanisms of CD28sa treatment against renal ischemia-reperfusion (IR) injury (IRI). METHODS: Male C57BL/6N mice were treated with CD28sa via peritoneal injection (0.1 mg) 6 days before the induction of IRI, or with 18-min ischemic precondition (IPC). IRI was induced by bilateral clamping of renal pedicles for 35 min followed by reperfusion. The role of Treg expansion in renal protection conferred by CD28sa treatment was examined using anti-CD25 antibody. RESULTS: CD28sa treatment alone significantly increased the percentage of Treg cells in the spleen (18.1...
Source: American Journal of Nephrology - March 29, 2017 Category: Urology & Nephrology Authors: Liang Y, Li Y, Kuang Q, Ding X, Wei Z, Fang Y Tags: Am J Nephrol Source Type: research

Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease.
Abstract BACKGROUND: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being investigated for the treatment of anemia secondary to CKD. METHODS: A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4. Eligible subjects were evenly randomized to 5 groups: 240, 370, 500, or 630 mg of once-daily oral vadadustat or placebo for 6 weeks...
Source: American Journal of Nephrology - March 25, 2017 Category: Urology & Nephrology Authors: Martin ER, Smith MT, Maroni BJ, Zuraw QC, deGoma EM Tags: Am J Nephrol Source Type: research

Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease
Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being investigated for the treatment of anemia secondary to CKD.Methods: A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4. Eligible subjects were evenly randomized to 5 groups: 240, 370, 500, or 630 mg of once-daily oral vadadustat or placebo for 6 weeks. All subjects received ...
Source: American Journal of Nephrology - March 24, 2017 Category: Neurology Source Type: research

The Evolving Role of Rituximab in Adult Minimal Change Glomerulopathy.
CONCLUSION: Rituximab induced remission in all patients with corticosteroid-dependent or -resistant minimal-change glomerulopathy, and may hold great therapeutic potential with good efficacy and minimal toxicity. Mounting evidence implies that a well-conducted randomized controlled clinical trial using rituximab in adults with minimal-change glomerulopathy in both corticosteroid-resistant and corticosteroid-dependent patients is warranted. PMID: 28315862 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2017 Category: Urology & Nephrology Authors: Brown LC, Jobson MA, Payan Schober F, Chang EH, Falk RJ, Nachman PH, Pendergraft WF Tags: Am J Nephrol Source Type: research

Comparison of Total Kidney Volume Quantification Methods in Autosomal Dominant Polycystic Disease for a Comprehensive Disease Assessment.
CONCLUSION: Considering the fact that the image-based technique is the only approach providing a 3D patient-specific kidney model and allowing further analysis including cyst volume computation and monitoring disease progression, we suggest that geometric assumption (e.g., EL method) should be avoided. The contour-detection approach should be used for a reproducible and precise morphologic classification of the renal volume of ADPKD patients. PMID: 28315882 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2017 Category: Urology & Nephrology Authors: Turco D, Busutti M, Mignani R, Magistroni R, Corsi C Tags: Am J Nephrol Source Type: research

The Evolving Role of Rituximab in Adult Minimal Change Glomerulopathy
Conclusion: Rituximab induced remission in all patients with corticosteroid-dependent or -resistant minimal-change glomerulopathy, and may hold great therapeutic potential with good efficacy and minimal toxicity. Mounting evidence implies that a well-conducted randomized controlled clinical trial using rituximab in adults with minimal-change glomerulopathy in both corticosteroid-resistant and corticosteroid-dependent patients is warranted.Am J Nephrol 2017;45:365-372 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2017 Category: Neurology Source Type: research

Comparison of Total Kidney Volume Quantification Methods in Autosomal Dominant Polycystic Disease for a Comprehensive Disease Assessment
Conclusion: Considering the fact that the image-based technique is the only approach providing a 3D patient-specific kidney model and allowing further analysis including cyst volume computation and monitoring disease progression, we suggest that geometric assumption (e.g., EL method) should be avoided. The contour-detection approach should be used for a reproducible and precise morphologic classification of the renal volume of ADPKD patients.Am J Nephrol 2017;45:373-379 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2017 Category: Neurology Source Type: research

Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients.
CONCLUSIONS: A low incidence of unnecessary AVF creation was revealed among Japanese patients who received AVF at CKD stage 5. These results may help clarify the natural history of unnecessary AVF creation for other countries reformatting their guidelines regarding late vascular access creation. PMID: 28301835 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 16, 2017 Category: Urology & Nephrology Authors: Miyamoto M, Kurita N, Suemitsu K, Murakami M Tags: Am J Nephrol Source Type: research

When Is the Right Time for Arteriovenous Fistula Placement in Patients with End-Stage Renal Disease?
PMID: 28301841 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 16, 2017 Category: Urology & Nephrology Authors: Hammes M Tags: Am J Nephrol Source Type: research

Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients
Conclusions: A low incidence of unnecessary AVF creation was revealed among Japanese patients who received AVF at CKD stage 5. These results may help clarify the natural history of unnecessary AVF creation for other countries reformatting their guidelines regarding late vascular access creation.Am J Nephrol 2017;45:356-364 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 16, 2017 Category: Neurology Source Type: research

When Is the Right Time for Arteriovenous Fistula Placement in Patients with End-Stage Renal Disease?
Am J Nephrol 2017;45:353-355 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 16, 2017 Category: Neurology Source Type: research

Patient-Doctor Contact Interval and Clinical Outcomes in Continuous Ambulatory Peritoneal Dialysis Patients.
Abstract BACKGROUND: The optimal patient-doctor contact (PDC) interval remains unknown in peritoneal dialysis (PD) patients. The aim was to investigate the association between PDC interval and clinical outcomes in continuous ambulatory PD (CAPD) patients. METHODS: In this retrospective cohort study, CAPD patients who resided in Guangzhou city between January 2006 and December 2012 were included. According to receiver operating characteristic curve analysis, all patients were classified as high (PDC interval ≤2 months) and low (PDC interval>2 months) PDC frequency groups. Biochemical data, clinical event...
Source: American Journal of Nephrology - March 13, 2017 Category: Urology & Nephrology Authors: Yi C, Guo Q, Lin J, Li J, Yu X, Yang X Tags: Am J Nephrol Source Type: research

Patient-Doctor Contact Interval and Clinical Outcomes in Continuous Ambulatory Peritoneal Dialysis Patients
Background: The optimal patient-doctor contact (PDC) interval remains unknown in peritoneal dialysis (PD) patients. The aim was to investigate the association between PDC interval and clinical outcomes in continuous ambulatory PD (CAPD) patients.Methods: In this retrospective cohort study, CAPD patients who resided in Guangzhou city between January 2006 and December 2012 were included. According to receiver operating characteristic curve analysis, all patients were classified as high (PDC interval ≤2 months) and low (PDC interval>2 months) PDC frequency groups. Biochemical data, clinical events, and clinical outcomes...
Source: American Journal of Nephrology - March 13, 2017 Category: Neurology Source Type: research

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function.
Abstract BACKGROUND: While elevated serum uric acid level (SUA) is a recognized risk factor for chronic kidney disease, it remains unclear whether change in SUA is independently associated with change in estimated glomerular filtration rate (eGFR) over time. Accordingly, we examined the longitudinal associations between change in SUA and change in eGFR over 5 years in a general Japanese population. METHODS: This was a large, single-center, retrospective 5-year cohort study at St. Luke's International Hospital, Tokyo, Japan, between 2004 and 2009. We included 13,070 subjects (30-85 years) in our analyses whose...
Source: American Journal of Nephrology - March 10, 2017 Category: Urology & Nephrology Authors: Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ Tags: Am J Nephrol Source Type: research

Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease.
Abstract BACKGROUND: Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD). METHODS: Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet history questionnaire and lifestyle assessment. We divided OBS into quartiles (Q1-Q4), with Q1 (predominance of pro-oxidants) as the reference. We analyzed OBS quartiles as an ordin...
Source: American Journal of Nephrology - March 10, 2017 Category: Urology & Nephrology Authors: Ilori TO, Wang X, Huang M, Gutierrez OM, Narayan KM, Goodman M, McClellan W, Plantinga L, Ojo AO Tags: Am J Nephrol Source Type: research

Uric Acid and Decline in Renal Function-Partners in Crime.
PMID: 28285315 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 10, 2017 Category: Urology & Nephrology Authors: Dawson J, Mark PB Tags: Am J Nephrol Source Type: research

Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease
Background: Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD).Methods: Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet history questionnaire and lifestyle assessment. We divided OBS into quartiles (Q1-Q4), with Q1 (predominance of pro-oxidants) as the reference. We analyzed OBS quartiles as an ordinal variable. Crude and a...
Source: American Journal of Nephrology - March 10, 2017 Category: Neurology Source Type: research

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function
Background: While elevated serum uric acid level (SUA) is a recognized risk factor for chronic kidney disease, it remains unclear whether change in SUA is independently associated with change in estimated glomerular filtration rate (eGFR) over time. Accordingly, we examined the longitudinal associations between change in SUA and change in eGFR over 5 years in a general Japanese population.Methods: This was a large, single-center, retrospective 5-year cohort study at St. Luke's International Hospital, Tokyo, Japan, between 2004 and 2009. We included 13,070 subjects (30-85 years) in our analyses whose data were available bet...
Source: American Journal of Nephrology - March 10, 2017 Category: Neurology Source Type: research

Uric Acid and Decline in Renal Function-Partners in Crime
Am J Nephrol 2017;45:327-329 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 10, 2017 Category: Neurology Source Type: research

Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition.
Abstract BACKGROUND: Creatinine and cystatin C concentrations are commonly used to estimate glomerular filtration rate (eGFR) in clinical practice and epidemiological studies. To estimate the influence of different body composition measures on eGFR from creatinine and cystatin C blood concentrations, we compared the associations of different anthropometric and body composition measures with eGFR derived from creatinine (eGFRcreat) and cystatin C (eGFRcystC) blood concentrations. METHODS: In a population-based cohort study among 4,305 children aged 6.0 years (95% range 5.7-8.0), we measured weight and height a...
Source: American Journal of Nephrology - February 28, 2017 Category: Urology & Nephrology Authors: Miliku K, Bakker H, Dorresteijn EM, Cransberg K, Franco OH, Felix JF, Jaddoe VW Tags: Am J Nephrol Source Type: research

Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition
Background: Creatinine and cystatin C concentrations are commonly used to estimate glomerular filtration rate (eGFR) in clinical practice and epidemiological studies. To estimate the influence of different body composition measures on eGFR from creatinine and cystatin C blood concentrations, we compared the associations of different anthropometric and body composition measures with eGFR derived from creatinine (eGFRcreat) and cystatin C (eGFRcystC) blood concentrations.Methods: In a population-based cohort study among 4,305 children aged 6.0 years (95% range 5.7-8.0), we measured weight and height and calculated body mass ...
Source: American Journal of Nephrology - February 28, 2017 Category: Neurology Source Type: research

Targeting Immunity in End-Stage Renal Disease.
Abstract BACKGROUND: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk. SUMMARY: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD. Indeed, this contrasts with the extensive scientific breakthroughs made in the basic field of sci...
Source: American Journal of Nephrology - February 24, 2017 Category: Urology & Nephrology Authors: Baragetti I, El Essawy B, Fiorina P Tags: Am J Nephrol Source Type: research

Rapamycin Enhances Repressed Autophagy and Attenuates Aggressive Progression in a Rat Model of IgA Nephropathy.
CONCLUSION: These results may suggest that mTOR-mediated autophagy inhibition may result in mesangial cell proliferation in IgAN. PMID: 28237991 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 24, 2017 Category: Urology & Nephrology Authors: Liu D, Liu Y, Chen G, He L, Tang C, Wang C, Yang D, Li H, Dong Z, Liu H Tags: Am J Nephrol Source Type: research

Targeting Immunity in End-Stage Renal Disease
Background: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk.Summary: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD. Indeed, this contrasts with the extensive scientific breakthroughs made in the basic field of science in targeting inflam...
Source: American Journal of Nephrology - February 24, 2017 Category: Neurology Source Type: research

Rapamycin Enhances Repressed Autophagy and Attenuates Aggressive Progression in a Rat Model of IgA Nephropathy
Conclusion: These results may suggest that mTOR-mediated autophagy inhibition may result in mesangial cell proliferation in IgAN.Am J Nephrol 2017;45:293-300 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 24, 2017 Category: Neurology Source Type: research

Renal Function and Scaled Troponin in Patients Presenting to the Emergency Department with Symptoms of Myocardial Infarction.
CONCLUSIONS: One or more elevated troponin values are common in those with renal dysfunction. Scaled troponins for eGFR groups were similar, indicating that the use of this interpretative technique is applicable in discerning AMI for those with and without renal dysfunction. PMID: 28192777 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 13, 2017 Category: Urology & Nephrology Authors: Vasudevan A, Singer AJ, DeFilippi C, Headden G, Schussler JM, Daniels LB, Reed M, Than MP, Birkhahn R, Smith SW, Barrett TW, Arnold W, Peacock WF, McCullough PA Tags: Am J Nephrol Source Type: research

Renal Function and Scaled Troponin in Patients Presenting to the Emergency Department with Symptoms of Myocardial Infarction
Conclusions: One or more elevated troponin values are common in those with renal dysfunction. Scaled troponins for eGFR groups were similar, indicating that the use of this interpretative technique is applicable in discerning AMI for those with and without renal dysfunction.Am J Nephrol 2017;45:304-309 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 13, 2017 Category: Neurology Source Type: research

Cardiac Troponins in Chronic Kidney Disease: A Marker of Global Cardiovascular Risk
Am J Nephrol 2017;45:301-303 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 13, 2017 Category: Neurology Source Type: research

Obesity and Kidney Disease: Hidden Consequences of the Epidemic
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in the long-term. The ...
Source: American Journal of Nephrology - February 8, 2017 Category: Neurology Source Type: research

Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients.
Abstract BACKGROUND: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. METHODS: This is a multicenter randomized controlled trial performed on 163 patients from 17 dialysis centers in Shanghai who were allocated to high- (n = 98) and standard-dose groups (n = 65) and followed through 96 weeks of study period. Therapeutic approaches were given to increase spKt/V to over 1.70 in the high-dose group. Data were collected every 12-24 weeks. The primary outcomes were al...
Source: American Journal of Nephrology - February 7, 2017 Category: Urology & Nephrology Authors: Fan Q, Yan Y, Gu L, He L, Chen N, Jiang G, Yuan L, Xue J, Zhang Y, Ma J, Jin H, Yuan W, Guo Z, Guo L, Wang N, Zhang W, Ye Z, Mao P, Pi X, Lu R, Zhu M, Zhang W, Ni Z, Qian J, Pang H Tags: Am J Nephrol Source Type: research

Obesity and Kidney Disease: Hidden Consequences of the Epidemic.
Abstract Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in t...
Source: American Journal of Nephrology - February 7, 2017 Category: Urology & Nephrology Authors: Kovesdy CP, Furth SL, Zoccali C, World Kidney Day Steering Committee Tags: Am J Nephrol Source Type: research

Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients
Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD.Methods: This is a multicenter randomized controlled trial performed on 163 patients from 17 dialysis centers in Shanghai who were allocated to high- (n = 98) and standard-dose groups (n = 65) and followed through 96 weeks of study period. Therapeutic approaches were given to increase spKt/V to over 1.70 in the high-dose group. Data were collected every 12-24 weeks. The primary outcomes were all-cause mortality and ma...
Source: American Journal of Nephrology - February 7, 2017 Category: Neurology Source Type: research

Rationale and Design of a Clinical Trial Investigating Tolvaptan Safety and Efficacy in Autosomal Dominant Polycystic Kidney Disease.
CONCLUSION: Replicating Evidence of Preserved Renal Function: An Investigation of Tolvaptan Safety and Efficacy (REPRISE) determines whether tolvaptan administered over 1 year exhibits disease-modifying properties in ADPKD patients with late stage 2 to early stage 4 CKD, which provides an important therapeutic advancement for this difficult-to-treat disease. PMID: 28166521 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 6, 2017 Category: Urology & Nephrology Authors: Torres VE, Devuyst O, Chapman AB, Gansevoort RT, Perrone RD, Ouyang J, Blais JD, Czerwiec FS, Sergeyeva O, REPRISE Trial Investigators Tags: Am J Nephrol Source Type: research

Rationale and Design of a Clinical Trial Investigating Tolvaptan Safety and Efficacy in Autosomal Dominant Polycystic Kidney Disease
Conclusion: Replicating Evidence of Preserved Renal Function: An Investigation of Tolvaptan Safety and Efficacy (REPRISE) determines whether tolvaptan administered over 1 year exhibits disease-modifying properties in ADPKD patients with late stage 2 to early stage 4 CKD, which provides an important therapeutic advancement for this difficult-to-treat disease.Am J Nephrol 2017;45:257-266 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 6, 2017 Category: Neurology Source Type: research

Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis.
CONCLUSION: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome. PMID: 28161700 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 3, 2017 Category: Urology & Nephrology Authors: Payan Schober F, Jobson MA, Poulton CJ, Singh HK, Nickeleit V, Falk RJ, Jennette JC, Nachman PH, Pendergraft Iii WF Tags: Am J Nephrol Source Type: research

Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis
Conclusion: According to this study, fibrillary glomerulonephritis represents a secondary glomerular disease process (associated with autoimmune disease, infection or malignancy) in many cases and hence screening is essential. As the screening for comorbidities increased over time, more underlying causes were identified. We noted a high frequency of HCV among black patients, suggesting a possible causative association. Treatment of underlying disease is essential for patients for the best outcome.Am J Nephrol 2017;45:248-256 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 3, 2017 Category: Neurology Source Type: research

The Association between Biomarker Profiles, Etiology of Chronic Kidney Disease, and Mortality.
CONCLUSIONS: Biomarkers profiles differ according to the etiology of CKD and are associated with mortality. PMID: 28147348 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2017 Category: Urology & Nephrology Authors: Langsford D, Tang M, Cheikh Hassan HI, Djurdjev O, Sood MM, Levin A Tags: Am J Nephrol Source Type: research

The Association between Biomarker Profiles, Etiology of Chronic Kidney Disease, and Mortality
Conclusions: Biomarkers profiles differ according to the etiology of CKD and are associated with mortality.Am J Nephrol 2017;45:226-234 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2017 Category: Neurology Source Type: research

History of Erythropoiesis-Stimulating Agents, the Development of Biosimilars, and the Future of Anemia Treatment in Nephrology.
Abstract BACKGROUND: Exogenous replacement of erythropoietin (EPO) by recombinant human EPO has been considered a standard of care for the treatment of anemia in patients with chronic kidney disease for more than 20 years. Genetically engineered biologic proteins derived from human, animal, or microorganism sources are a major area of growth in modern medical care, accounting for one-third of new drug approvals in the past decade. Despite benefit to patients, the use of biologics comes at a significant cost, representing one of the fastest growing segments of strained healthcare budgets around the world. SUMM...
Source: American Journal of Nephrology - January 31, 2017 Category: Urology & Nephrology Authors: Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

History of Erythropoiesis-Stimulating Agents, the Development of Biosimilars, and the Future of Anemia Treatment in Nephrology
Background: Exogenous replacement of erythropoietin (EPO) by recombinant human EPO has been considered a standard of care for the treatment of anemia in patients with chronic kidney disease for more than 20 years. Genetically engineered biologic proteins derived from human, animal, or microorganism sources are a major area of growth in modern medical care, accounting for one-third of new drug approvals in the past decade. Despite benefit to patients, the use of biologics comes at a significant cost, representing one of the fastest growing segments of strained healthcare budgets around the world.Summary: Biosimilars, or bio...
Source: American Journal of Nephrology - January 31, 2017 Category: Neurology Source Type: research