Acute Kidney Injury after Transcatheter Aortic Valve Replacement
Am J Nephrol 2015;41:370-371 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Neurology Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement.
PMID: 26113253 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Urology & Nephrology Authors: Mohandas R, Anderson RD, Pepine CJ Tags: Am J Nephrol Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Our meta-analysis demonstrates an association between TAVR and lower AKI risk. © 2015 S. Karger AG, Basel. PMID: 26113391 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Urology & Nephrology Authors: Thongprayoon C, Cheungpasitporn W, Srivali N, Ungprasert P, Kittanamongkolchai W, Greason KL, Kashani KB Tags: Am J Nephrol Source Type: research

Interpreting CD56+ and CD163+ Infiltrates in Early versus Late Renal Transplant Biopsies.
CONCLUSIONS: Intragraft CD56+ cell infiltrates were significantly associated with AMR and subsequent poor clinical outcomes. © 2015 S. Karger AG, Basel. PMID: 26087825 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 18, 2015 Category: Urology & Nephrology Authors: Shin S, Kim YH, Cho YM, Park Y, Han S, Choi BH, Choi JY, Han DJ Tags: Am J Nephrol Source Type: research

Interpreting CD56+ and CD163+ Infiltrates in Early versus Late Renal Transplant Biopsies
Conclusions: Intragraft CD56+ cell infiltrates were significantly associated with AMR and subsequent poor clinical outcomes.Am J Nephrol 2015;41:362-369 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 17, 2015 Category: Neurology Source Type: research

Trends in Anemia Management Practices in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Retrospective Cohort Analysis
Conclusions: In patients receiving persistent dialysis, dose and frequency of ESA administrations decreased during the period 2007-2011. Mean hemoglobin levels decreased by more than 1 g/dl, while transfusion rates increased by approximately 25%.Am J Nephrol 2015;41:354-361 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 16, 2015 Category: Neurology Source Type: research

A Pathological Scoring System to Predict Renal Outcome in Diabetic Nephropathy
Conclusion: Prediction of DN patients' renal outcome was better with the D-score than without it. Patients with a D-score ≤14 had excellent renal prognosis.Am J Nephrol 2015;41:337-344 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption
Background: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle dysfunction, which can be applied to study the severity and the reversibility of ESRD myopathy. We tested the hypothesis that deconditioning is a relevant factor in ESRD myopathy. Methods: The whole dialysis population (n = 59) of two of the eight centers participating into the EXCITE study (ClinicalTrials.gov NCT01255969), a randomized trial evaluating the effect of a home-based exerc...
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy
Conclusion: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN.Am J Nephrol 2015;41:345-353 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Estimated Pulmonary Artery Systolic Pressure and Self-Reported Physical Function in Patients on Hemodialysis
Conclusion: Left ventricular hypertrophy and elevated pulmonary pressure are associated with worse self-reported physical function in patients on hemodialysis. The role of chronic volume overload on PASP and PF score should be evaluated in a prospective manner.Am J Nephrol 2015;41:313-319 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy.
CONCLUSION: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN. © 2015 S. Karger AG, Basel. PMID: 26087695 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 13, 2015 Category: Urology & Nephrology Authors: Xie Q, Li Y, Xue J, Xiong Z, Wang L, Sun Z, Ren Y, Zhu X, Hao CM Tags: Am J Nephrol Source Type: research

Estimated Pulmonary Artery Systolic Pressure and Self-Reported Physical Function in Patients on Hemodialysis.
CONCLUSION: Left ventricular hypertrophy and elevated pulmonary pressure are associated with worse self-reported physical function in patients on hemodialysis. The role of chronic volume overload on PASP and PF score should be evaluated in a prospective manner. © 2015 S. Karger AG, Basel. PMID: 26089100 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 13, 2015 Category: Urology & Nephrology Authors: Abreo AP, Herzog CA, Kutner NG, Lea J, Johansen KL Tags: Am J Nephrol Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption.
ali C Abstract BACKGROUND: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle dysfunction, which can be applied to study the severity and the reversibility of ESRD myopathy. We tested the hypothesis that deconditioning is a relevant factor in ESRD myopathy. METHODS: The whole dialysis population (n = 59) of two of the eight centers participating into the EXCITE study (ClinicalTrials.gov NCT01255969), a randomized trial evaluating the...
Source: American Journal of Nephrology - June 11, 2015 Category: Urology & Nephrology Authors: Manfredini F, Lamberti N, Malagoni AM, Felisatti M, Zuccalà A, Torino C, Tripepi G, Catizone L, Mallamaci F, Zoccali C Tags: Am J Nephrol Source Type: research

A Pathological Scoring System to Predict Renal Outcome in Diabetic Nephropathy.
CONCLUSION: Prediction of DN patients' renal outcome was better with the D-score than without it. Patients with a D-score ≤14 had excellent renal prognosis. © 2015 S. Karger AG, Basel. PMID: 26067713 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 11, 2015 Category: Urology & Nephrology Authors: Hoshino J, Mise K, Ueno T, Imafuku A, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Sawa N, Hara S, Fujii T, Ohashi K, Ubara Y, Takaichi K Tags: Am J Nephrol Source Type: research

Renal Function and Long-Term Decline in Cognitive Function: The Baltimore Longitudinal Study of Aging
Background: Renal disease has been associated with greater risk of dementia and greater cognitive impairment. However, the relationship of lower renal function with long-term decline in specific domains of cognitive function remains unclear among community-dwelling, non-demented individuals. Methods: Stroke- and dementia-free participants (n = 2,116) were enrolled in the Baltimore Longitudinal Study of Aging, a community-based, prospective, longitudinal study. Renal function was estimated by the inverse of serum creatinine adjusted for age, sex and race and (in sensitivity analyses) estimated glomerular filtration rate (eG...
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Aortic Stiffness and Kidney Disease in an Elderly Population
Conclusion: Greater aortic stiffness may be associated with modestly higher levels of albuminuria in the elderly. The association between aortic stiffness and lower eGFR may be confounded by age and CVD risk factors.Am J Nephrol 2015;41:320-328 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Early Kidney Disease, an Important Factor in Cognitive Decline or Merely a Harbinger of Early Vascular Brain Injury?
Am J Nephrol 2015;41:303-304 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Early Kidney Disease, an Important Factor in Cognitive Decline or Merely a Harbinger of Early Vascular Brain Injury?
PMID: 26067178 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Urology & Nephrology Authors: Lewis JR Tags: Am J Nephrol Source Type: research

Aortic Stiffness and Kidney Disease in an Elderly Population.
CONCLUSION: Greater aortic stiffness may be associated with modestly higher levels of albuminuria in the elderly. The association between aortic stiffness and lower eGFR may be confounded by age and CVD risk factors. © 2015 S. Karger AG, Basel. PMID: 26067356 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Urology & Nephrology Authors: Michener KH, Mitchell GF, Noubary F, Huang N, Harris T, Andresdottir MB, Palsson R, Gudnason V, Levey AS Tags: Am J Nephrol Source Type: research

Hemodialysis Patients with Hepatitis C Infection Are Not Receiving the New Antiviral Medications
Am J Nephrol 2015;41:302 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 3, 2015 Category: Neurology Source Type: research

Hemodialysis Patients with Hepatitis C Infection Are Not Receiving the New Antiviral Medications.
PMID: 26044708 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 3, 2015 Category: Urology & Nephrology Authors: Goodkin DA, Bieber B Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab.
CONCLUSION: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide. © 2015 S. Karger AG, Basel. PMID: 26044574 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 2, 2015 Category: Urology & Nephrology Authors: Shah S, Hruskova Z, Segelmark M, Morgan MD, Hogan J, Lee SK, Dale J, Harper L, Tesar V, Jayne DR, Geetha D Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab
Conclusion: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide.Am J Nephrol 2015;41:296-301 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2015 Category: Neurology Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States.
CONCLUSIONS: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society. © 2015 S. Karger AG, Basel. PMID: 26044456 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 30, 2015 Category: Urology & Nephrology Authors: Moradi H, Abhari P, Streja E, Kashyap ML, Shah G, Gillen D, Pahl MV, Vaziri ND, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States
Conclusions: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society.Am J Nephrol 2015;41:284-295 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2015 Category: Neurology Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients
Conclusion: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN.Am J Nephrol 2015;41:277-283 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future
Am J Nephrol 2015;41:275-276 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future?
PMID: 26021407 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: White K Tags: Am J Nephrol Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients.
CONCLUSION: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN. © 2015 S. Karger AG, Basel. PMID: 26021523 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: Harindhanavudhi T, Parks A, Mauer M, Caramori ML Tags: Am J Nephrol Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study
Background and Objectives: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 20, 2015 Category: Neurology Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study.
Abstract BACKGROUND AND OBJECTIVES: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR)
Source: American Journal of Nephrology - May 20, 2015 Category: Urology & Nephrology Authors: Foster MC, Hwang SJ, Massaro JM, Jacques PF, Fox CS, Chu AY Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells.
CONCLUSION: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy. © 2015 S. Karger AG, Basel. PMID: 25924590 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2015 Category: Urology & Nephrology Authors: Cheng M, Liu H, Zhang D, Liu Y, Wang C, Liu F, Chen J Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells
Conclusion: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy.Am J Nephrol 2015;41:257-266 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 27, 2015 Category: Neurology Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus.
CONCLUSION: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations. © 2015 S. Karger AG, Basel. PMID: 25926050 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Orjuela A, Suwanichkul A, Canter D, Minard CG, Devaraj S, Hicks MJ, Muscal E, Wenderfer SE Tags: Am J Nephrol Source Type: research

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. METHODS: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR ((125)I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. RESULTS: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-...
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Casteleijn NF, Zittema D, Bakker SJ, Boertien WE, Gaillard CA, Meijer E, Spithoven EM, Struck J, Gansevoort RT Tags: Am J Nephrol Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus
Conclusion: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations.Am J Nephrol 2015;41:241-247 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. Methods: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (125I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. Results: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m2, TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, ...
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications
Conclusion: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment.Am J Nephrol 2015;41:231-240 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications.
CONCLUSION: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment. © 2015 S. Karger AG, Basel. PMID: 25896309 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Urology & Nephrology Authors: Lam NN, Garg AX, Segev DL, Schnitzler MA, Xiao H, Axelrod D, Brennan DC, Kasiske BL, Tuttle-Newhall JE, Lentine KL Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice.
CONCLUSION: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease. © 2015 S. Karger AG, Basel. PMID: 25896231 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 16, 2015 Category: Urology & Nephrology Authors: Ranganathan P, Mohamed R, Jayakumar C, Brands MW, Ramesh G Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice
Conclusion: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease.Am J Nephrol 2015;41:220-230 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy.
ter A, Bjørneklett R Abstract BACKGROUND: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filt...
Source: American Journal of Nephrology - April 9, 2015 Category: Urology & Nephrology Authors: Knoop T, Vågane AM, Vikse BE, Svarstad E, Magnúsdóttir BT, Leh S, Varberg Reisæter A, Bjørneklett R Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy
Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filtration rate (eGFR) and age improved prediction...
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible.
Abstract Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinico-radiological condition that can result in severe brain injury. The pathogenesis of cerebral vasogenic edema, the hallmark of PRES, is not fully understood. Despite its name, there is substantial heterogeneity both in terms of imaging findings and outcome. Relatively little is known about PRES in kidney disease despite the clustering of risk factors including hypertension, autoimmune disease and immunosuppression. In a retrospective observational study of incident end-stage kidney disease patients in Southwest Ireland over a ten yea...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Canney M, Kelly D, Clarkson M Tags: Am J Nephrol Source Type: research

The Risk of Hyponatremia with Desmopressin Use for Nocturnal Polyuria.
This study was undertaken to characterize hyponatremia occurring in adults using desmopressin for nocturnal polyuria. METHODS: Data from 172 patients who were prescribed desmopressin for nocturnal polyuria at a urology clinic from September 2010 through February 2013 were retrospectively analyzed. Demographic and laboratory parameters were investigated to examine the risk factors for desmopressin-associated hyponatremia. RESULTS: The average follow-up serum sodium measured 21 ± 22 days after using desmopressin was 138 ± 5 mmol/l. Hyponatremia (
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Choi EY, Park JS, Kim YT, Park SY, Kim GH Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
CONCLUSION: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity. © 2015 S. Karger AG, Basel. PMID: 25871823 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Loeser H, von Brandenstein M, Herschung A, Schlosser M, Büttner R, Fries JW Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort.
Abstract BACKGROUND: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. METHODS: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na(+)) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and Na(+) ...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Han SW, Tilea A, Gillespie BW, Finkelstein FO, Kiser MA, Eisele G, Kotanko P, Levin N, Saran R Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort
Background: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. Methods: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na+) and clinical outcomes. Results: Baseline estimated glomerular filtration rate (eGFR) and Na+ were 26 ± 11 ml/min/1.73 ...
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research