Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. METHODS: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR ((125)I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. RESULTS: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-...
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Casteleijn NF, Zittema D, Bakker SJ, Boertien WE, Gaillard CA, Meijer E, Spithoven EM, Struck J, Gansevoort RT Tags: Am J Nephrol Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus
Conclusion: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations.Am J Nephrol 2015;41:241-247 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. Methods: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (125I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. Results: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m2, TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, ...
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications
Conclusion: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment.Am J Nephrol 2015;41:231-240 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications.
CONCLUSION: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment. © 2015 S. Karger AG, Basel. PMID: 25896309 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Urology & Nephrology Authors: Lam NN, Garg AX, Segev DL, Schnitzler MA, Xiao H, Axelrod D, Brennan DC, Kasiske BL, Tuttle-Newhall JE, Lentine KL Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice.
CONCLUSION: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease. © 2015 S. Karger AG, Basel. PMID: 25896231 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 16, 2015 Category: Urology & Nephrology Authors: Ranganathan P, Mohamed R, Jayakumar C, Brands MW, Ramesh G Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice
Conclusion: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease.Am J Nephrol 2015;41:220-230 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy.
ter A, Bjørneklett R Abstract BACKGROUND: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filt...
Source: American Journal of Nephrology - April 9, 2015 Category: Urology & Nephrology Authors: Knoop T, Vågane AM, Vikse BE, Svarstad E, Magnúsdóttir BT, Leh S, Varberg Reisæter A, Bjørneklett R Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy
Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filtration rate (eGFR) and age improved prediction...
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible.
Abstract Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinico-radiological condition that can result in severe brain injury. The pathogenesis of cerebral vasogenic edema, the hallmark of PRES, is not fully understood. Despite its name, there is substantial heterogeneity both in terms of imaging findings and outcome. Relatively little is known about PRES in kidney disease despite the clustering of risk factors including hypertension, autoimmune disease and immunosuppression. In a retrospective observational study of incident end-stage kidney disease patients in Southwest Ireland over a ten yea...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Canney M, Kelly D, Clarkson M Tags: Am J Nephrol Source Type: research

The Risk of Hyponatremia with Desmopressin Use for Nocturnal Polyuria.
This study was undertaken to characterize hyponatremia occurring in adults using desmopressin for nocturnal polyuria. METHODS: Data from 172 patients who were prescribed desmopressin for nocturnal polyuria at a urology clinic from September 2010 through February 2013 were retrospectively analyzed. Demographic and laboratory parameters were investigated to examine the risk factors for desmopressin-associated hyponatremia. RESULTS: The average follow-up serum sodium measured 21 ± 22 days after using desmopressin was 138 ± 5 mmol/l. Hyponatremia (
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Choi EY, Park JS, Kim YT, Park SY, Kim GH Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
CONCLUSION: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity. © 2015 S. Karger AG, Basel. PMID: 25871823 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Loeser H, von Brandenstein M, Herschung A, Schlosser M, Büttner R, Fries JW Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort.
Abstract BACKGROUND: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. METHODS: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na(+)) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and Na(+) ...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Han SW, Tilea A, Gillespie BW, Finkelstein FO, Kiser MA, Eisele G, Kotanko P, Levin N, Saran R Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort
Background: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. Methods: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na+) and clinical outcomes. Results: Baseline estimated glomerular filtration rate (eGFR) and Na+ were 26 ± 11 ml/min/1.73 ...
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

The Risk of Hyponatremia with Desmopressin Use for Nocturnal Polyuria
This study was undertaken to characterize hyponatremia occurring in adults using desmopressin for nocturnal polyuria. Methods: Data from 172 patients who were prescribed desmopressin for nocturnal polyuria at a urology clinic from September 2010 through February 2013 were retrospectively analyzed. Demographic and laboratory parameters were investigated to examine the risk factors for desmopressin-associated hyponatremia. Results: The average follow-up serum sodium measured 21 ± 22 days after using desmopressin was 138 ± 5 mmol/l. Hyponatremia ( (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible
Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinico-radiological condition that can result in severe brain injury. The pathogenesis of cerebral vasogenic edema, the hallmark of PRES, is not fully understood. Despite its name, there is substantial heterogeneity both in terms of imaging findings and outcome. Relatively little is known about PRES in kidney disease despite the clustering of risk factors including hypertension, autoimmune disease and immunosuppression. In a retrospective observational study of incident end-stage kidney disease patients in Southwest Ireland over a ten year period, we disco...
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

Associations of Pre-Transplant Prescription Narcotic Use with Clinical Complications after Kidney Transplantation.
We examined integrated national transplant registry, pharmacy records, and Medicare billing claims to follow 16,322 kidney transplant recipients, of whom 28.3% filled a narcotic prescription in the year before transplantation. Opioid analgesic fills were normalized to morphine equivalents (ME) and expressed as mg/kg exposures (approximate quartiles: 0.1-1.7, 1.8-5.4, 5.5-23.7, and ≥23.8 mg/kg, respectively). Post-transplant cardiovascular, respiratory, neurological, accidents, substance abuse, and noncompliance events were identified using diagnosis codes on Medicare billing claims. Adjusted associations of ME level wit...
Source: American Journal of Nephrology - April 3, 2015 Category: Urology & Nephrology Authors: Lentine KL, Lam NN, Xiao H, Tuttle-Newhall JE, Axelrod D, Brennan DC, Dharnidharka VR, Yuan H, Nazzal M, Zheng J, Schnitzler MA Tags: Am J Nephrol Source Type: research

Association between Circulating Thrombopoietin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients
Background/Aims: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoietin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. Methods: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (MVA) was performed betwe...
Source: American Journal of Nephrology - April 3, 2015 Category: Neurology Source Type: research

Associations of Pre-Transplant Prescription Narcotic Use with Clinical Complications after Kidney Transplantation
We examined integrated national transplant registry, pharmacy records, and Medicare billing claims to follow 16,322 kidney transplant recipients, of whom 28.3% filled a narcotic prescription in the year before transplantation. Opioid analgesic fills were normalized to morphine equivalents (ME) and expressed as mg/kg exposures (approximate quartiles: 0.1-1.7, 1.8-5.4, 5.5-23.7, and ≥23.8 mg/kg, respectively). Post-transplant cardiovascular, respiratory, neurological, accidents, substance abuse, and noncompliance events were identified using diagnosis codes on Medicare billing claims. Adjusted associations of ME level wit...
Source: American Journal of Nephrology - March 27, 2015 Category: Neurology Source Type: research

Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Function Decline and Kidney Disease-Related Clinical Events in Older Women.
Abstract BACKGROUND: It is still unclear whether serum neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal tubular injury, is a prognostic marker for the progression of chronic kidney disease (CKD) in the general population. METHODS: A prospective-cohort study of 1,245 women aged ≥70 from the general population. Associations between plasma NGAL and change in 5-year estimated glomerular filtration rate (eGFR), rapid renal decline and 10-year risk of acute or chronic renal disease-related hospitalisations and/or mortality were examined. RESULTS: Compared to women with above-median pl...
Source: American Journal of Nephrology - March 25, 2015 Category: Urology & Nephrology Authors: Lim WH, Lewis JR, Wong G, Teo R, Lim EM, Byrnes E, Prince RL Tags: Am J Nephrol Source Type: research

Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Function Decline and Kidney Disease-Related Clinical Events in Older Women
Background: It is still unclear whether serum neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal tubular injury, is a prognostic marker for the progression of chronic kidney disease (CKD) in the general population. Methods: A prospective-cohort study of 1,245 women aged ≥70 from the general population. Associations between plasma NGAL and change in 5-year estimated glomerular filtration rate (eGFR), rapid renal decline and 10-year risk of acute or chronic renal disease-related hospitalisations and/or mortality were examined. Results: Compared to women with above-median plasma NGAL of 76.5 ng/l, wome...
Source: American Journal of Nephrology - March 24, 2015 Category: Neurology Source Type: research

Association between Circulating Thrombopoeitin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients
Background/Aims: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoeitin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. Methods: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (MVA) was performed betwe...
Source: American Journal of Nephrology - March 20, 2015 Category: Neurology Source Type: research

Association between Circulating Thrombopoeitin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients.
Abstract BACKGROUND/AIMS: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoeitin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. METHODS: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (M...
Source: American Journal of Nephrology - March 19, 2015 Category: Urology & Nephrology Authors: Mansell H, Elmoselhi H, Shoker A Tags: Am J Nephrol Source Type: research

Hypocalcemia Post Denosumab in Patients with Chronic Kidney Disease Stage 4-5.
CONCLUSIONS: A high rate of severe hypocalcemia was observed in patients with advanced CKD treated with denosumab. If denosumab is used in patients with severe CKD, close monitoring and aggressive replacement of calcium and calcitriol is required to avoid the development of hypocalcemia. © 2015 S. Karger AG, Basel. PMID: 25790847 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 18, 2015 Category: Urology & Nephrology Authors: Dave V, Chiang CY, Booth J, Mount PF Tags: Am J Nephrol Source Type: research

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan.
Abstract BACKGROUND: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. METHODS: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis...
Source: American Journal of Nephrology - March 18, 2015 Category: Urology & Nephrology Authors: Wakasugi M, Kazama JJ, Narita I, Konta T, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Asahi K, Kimura K, Kondo M, Kurahashi I, Ohashi Y, Watanabe T Tags: Am J Nephrol Source Type: research

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan
Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine th...
Source: American Journal of Nephrology - March 17, 2015 Category: Neurology Source Type: research

Hypocalcemia Post Denosumab in Patients with Chronic Kidney Disease Stage 4-5
Conclusions: A high rate of severe hypocalcemia was observed in patients with advanced CKD treated with denosumab. If denosumab is used in patients with severe CKD, close monitoring and aggressive replacement of calcium and calcitriol is required to avoid the development of hypocalcemia.Am J Nephrol 2015;41:129-137 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2015 Category: Neurology Source Type: research

CKD in Disadvantaged Populations.
PMID: 25766137 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2015 Category: Urology & Nephrology Authors: Garcia-Garcia G, Jha V Tags: Am J Nephrol Source Type: research

One-Year Mortality Rates in US Children with End-Stage Renal Disease.
CONCLUSIONS: One-year mortality rates differ by treatment modality in pediatric ESRD patients. © 2015 S. Karger AG, Basel. PMID: 25766310 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2015 Category: Urology & Nephrology Authors: Chavers BM, Molony JT, Solid CA, Rheault MN, Collins AJ Tags: Am J Nephrol Source Type: research

CKD in Disadvantaged Populations
Am J Nephrol 2015;41:116-120 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 6, 2015 Category: Neurology Source Type: research

One-Year Mortality Rates in US Children with End-Stage Renal Disease
Conclusions: One-year mortality rates differ by treatment modality in pediatric ESRD patients.Am J Nephrol 2015;41:121-128 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 6, 2015 Category: Neurology Source Type: research

Fasting Plasma Glucose Levels Predict Steroid-Induced Abnormal Glucose Metabolism in Patients with Non-Diabetic Chronic Kidney Disease: A Prospective Cohort Study.
Abstract BACKGROUND/AIMS: Glucocorticoids-induced abnormal glucose metabolism (AGM) is a common medical problem in patients with non-diabetic chronic kidney disease (CKD). However, little information is available regarding the prediction of steroid-induced AGM in this patient population. METHODS: In this prospective cohort study, we consecutively enrolled 303 non-diabetic CKD patients with fasting plasma glucose (FPG) levels
Source: American Journal of Nephrology - March 4, 2015 Category: Urology & Nephrology Authors: Yang X, Lin X, Lu T, Chen P, Wang X, Hou FF Tags: Am J Nephrol Source Type: research

Fasting Plasma Glucose Levels Predict Steroid-Induced Abnormal Glucose Metabolism in Patients with Non-Diabetic Chronic Kidney Disease: A Prospective Cohort Study
Background/Aims: Glucocorticoids-induced abnormal glucose metabolism (AGM) is a common medical problem in patients with non-diabetic chronic kidney disease (CKD). However, little information is available regarding the prediction of steroid-induced AGM in this patient population. Methods: In this prospective cohort study, we consecutively enrolled 303 non-diabetic CKD patients with fasting plasma glucose (FPG) levels (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 3, 2015 Category: Neurology Source Type: research

Clinicopathologic Features of IgA-Dominant Infection-Associated Glomerulonephritis: A Pooled Analysis of 78 Cases
Conclusions: IgA-dominant IAGN has unique clinicopathological manifestations and treatment responses. Age and DM are independent risk factors associated with an unfavorable prognosis for IgA-dominant IAGN.Am J Nephrol 2015;41:98-106 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 3, 2015 Category: Neurology Source Type: research

Clinicopathologic Features of IgA-Dominant Infection-Associated Glomerulonephritis: A Pooled Analysis of 78 Cases.
CONCLUSIONS: IgA-dominant IAGN has unique clinicopathological manifestations and treatment responses. Age and DM are independent risk factors associated with an unfavorable prognosis for IgA-dominant IAGN. © 2015 S. Karger AG, Basel. PMID: 25765902 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 3, 2015 Category: Urology & Nephrology Authors: Bu R, Li Q, Duan ZY, Wu J, Chen P, Chen XM, Cai GY Tags: Am J Nephrol Source Type: research

The Cost Effectiveness of Erythropoietin-Stimulating Agents for Treating Anemia in Patients on Dialysis: A Systematic Review
Conclusions: There is substantial variability in the estimates of the cost-effectiveness of using ESAs in the dialysis population. New models incorporating recent meta-analyses for estimates of utility, mortality, and hospitalization changes would allow for a more comprehensive answer to this question.Am J Nephrol 2015;41:89-97 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 26, 2015 Category: Neurology Source Type: research

The Cost Effectiveness of Erythropoietin-Stimulating Agents for Treating Anemia in Patients on Dialysis: A Systematic Review.
Conclusions: There is substantial variability in the estimates of the cost-effectiveness of using ESAs in the dialysis population. New models incorporating recent meta-analyses for estimates of utility, mortality, and hospitalization changes would allow for a more comprehensive answer to this question. © 2015 S. Karger AG, Basel. PMID: 25721696 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 26, 2015 Category: Urology & Nephrology Authors: Ferguson T, Xu Y, Gunasekara R, Lerner B, Macdonald K, Rigatto C, Tangri N, Komenda P Tags: Am J Nephrol Source Type: research

Smoking-related glomerulopathy: expanding the morphologic spectrum.
CONCLUSIONS: Kidney biopsies from patients with proteinuria and chronic renal insufficiency in the setting of prolonged smoking and hypertension show either diffuse or nodular mesangial glomerulosclerosis. Chronic glomerular mesangial and endothelial injury associated with smoking leads to a chronic TMA appearance in the appropriate setting, even in the absence of mesangial nodule formation. © 2015 S. Karger AG, Basel. PMID: 25659349 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 14, 2015 Category: Urology & Nephrology Authors: Salvatore SP, Troxell ML, Hecox D, Sperling KR, Seshan SV Tags: Am J Nephrol Source Type: research

Renal c3 complement component: feed forward to diabetic kidney disease.
CONCLUSIONS: We conclude that local activation of the complement system mediates renal injury in diabetic nephropathy. © 2015 S. Karger AG, Basel. PMID: 25662584 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 14, 2015 Category: Urology & Nephrology Authors: Kelly KJ, Liu Y, Zhang J, Dominguez JH Tags: Am J Nephrol Source Type: research

Renal function decline in recipients and donors of kidney grafts: role of aortic stiffness.
Abstract BACKGROUND/AIMS: Renal function decreases over time as a result of reduction in the number of functioning nephrons with age. In recipients and donors of kidney grafts, renal function decline may be linked differently to various parameters, namely arterial stiffness. METHODS: We conducted a prospective cohort study including 101 recipients of kidney grafts and their donors aiming at determining the factors correlated to the renal function decline over time. Aortic stiffness was evaluated by the non-invasive measurement of aortic pulse wave velocity. The glomerular filtration rate was estimated using t...
Source: American Journal of Nephrology - February 14, 2015 Category: Urology & Nephrology Authors: Bahous SA, Khairallah M, Al Danaf J, Halaby R, Korjian S, Daaboul Y, Salameh P, Stephan A, Blacher J, Safar ME Tags: Am J Nephrol Source Type: research

Risk of Major Hemorrhage after Kidney Transplantation.
Conclusion: Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general population, with about 1 in 30 recipients experiencing a major hemorrhage in the three years following transplant. © 2015 S. Karger AG, Basel. PMID: 25677869 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 14, 2015 Category: Urology & Nephrology Authors: Sood MM, Garg AX, Bota SE, Marisiddappa L, McArthur E, Naylor KL, Kapral MK, Kim SJ, Lam NN, Molnar AO, Harel Z, Perl J, Knoll GA Tags: Am J Nephrol Source Type: research

Variation in Risk and Mortality of Acute Kidney Injury in Critically Ill Patients: A Multicenter Study.
Abstract Background: Despite standardized definitions of acute kidney injury (AKI), there is wide variation in the reported rates of AKI and hospital mortality for patients with AKI. Variation could be due to actual differences in disease incidence, clinical course, or a function of data ascertainment and application of diagnostic criteria. Using standard criteria may help determine and compare the risk and outcomes of AKI across centers. Methods: In this cohort study of critically ill patients admitted to the intensive care units at six hospitals in four countries, we used KDIGO criteria to define AKI. The main o...
Source: American Journal of Nephrology - February 14, 2015 Category: Urology & Nephrology Authors: Srisawat N, Sileanu FE, Murugan R, Bellomod R, Calzavacca P, Cartin-Ceba R, Cruz D, Finn J, Hoste EE, Kashani K, Ronco C, Webb S, Kellum JA Tags: Am J Nephrol Source Type: research

Risk of Major Hemorrhage after Kidney Transplantation
Conclusion: Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general population, with about 1 in 30 recipients experiencing a major hemorrhage in the three years following transplant.Am J Nephrol 2015;41:73-80 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2015 Category: Neurology Source Type: research

Variation in Risk and Mortality of Acute Kidney Injury in Critically Ill Patients: A Multicenter Study
Background: Despite standardized definitions of acute kidney injury (AKI), there is wide variation in the reported rates of AKI and hospital mortality for patients with AKI. Variation could be due to actual differences in disease incidence, clinical course, or a function of data ascertainment and application of diagnostic criteria. Using standard criteria may help determine and compare the risk and outcomes of AKI across centers. Methods: In this cohort study of critically ill patients admitted to the intensive care units at six hospitals in four countries, we used KDIGO criteria to define AKI. The main outcomes were the o...
Source: American Journal of Nephrology - February 11, 2015 Category: Neurology Source Type: research

Contents Vol. 40, 2014
Am J Nephrol 2014;40:I-VI (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 5, 2015 Category: Neurology Source Type: research

Smoking-Related Glomerulopathy: Expanding the Morphologic Spectrum
Conclusions: Kidney biopsies from patients with proteinuria and chronic renal insufficiency in the setting of prolonged smoking and hypertension show either diffuse or nodular mesangial glomerulosclerosis. Chronic glomerular mesangial and endothelial injury associated with smoking leads to a chronic TMA appearance in the appropriate setting, even in the absence of mesangial nodule formation.Am J Nephrol 2015;41:66-72 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 5, 2015 Category: Neurology Source Type: research

High Phosphorus Level Leads to Aortic Calcification via β-Catenin in Chronic Kidney Disease.
CONCLUSION: These results suggest that β-catenin is an important player in high phosphorus level-induced aortic calcification in CKD. © 2015 S. Karger AG, Basel. PMID: 25634106 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 5, 2015 Category: Urology & Nephrology Authors: Yao L, Sun YT, Sun W, Xu TH, Ren C, Fan X, Sun L, Liu LL, Feng JM, Ma JF, Wang LN Tags: Am J Nephrol Source Type: research

Single-dose rituximab for recurrent glomerulonephritis post-renal transplant.
CONCLUSION: Single-dose rituximab for treatment of recurrent GN was associated with less subsequent rejection and longer time to graft loss without increased infection, but was no more effective than regimens not using rituximab at 36-months except those with recurrent membranous GN. © 2015 S. Karger AG, Basel. PMID: 25634230 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 5, 2015 Category: Urology & Nephrology Authors: Spinner ML, Bowman LJ, Horwedel TA, Delos Santos RB, Klein CL, Brennan DC Tags: Am J Nephrol Source Type: research