Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications
Background: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. Summary: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indications. The evidence-based a...
Source: American Journal of Nephrology - February 5, 2016 Category: Neurology Source Type: research

Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications.
Abstract BACKGROUND: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. SUMMARY: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indication...
Source: American Journal of Nephrology - February 5, 2016 Category: Urology & Nephrology Authors: Fiorentino M, Bolignano D, Tesar V, Pisano A, Van Biesen W, D'Arrigo G, Tripepi G, Gesualdo L, ERA-EDTA Immunonephrology Working Group Tags: Am J Nephrol Source Type: research

Novel Stratification of Mortality Risk by Kidney Disease Stage
Conclusion: IMRS is a strong predictor of mortality in patients with CKD and is robustly complementary to CKD stage in refining risk prediction. Given the universal availability and low cost of the CBC and BMP, IMRS may be of a substantial value in CKD risk assessment and management.Am J Nephrol 2015;42:443-450 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2016 Category: Neurology Source Type: research

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature
We present a case of a 49-year-old female with an atypical presentation of LN who initially presented with new-onset hypertension, edema, arthritis, serositis and recently diagnosed leukocytoclastic vasculitis who later developed acute kidney injury, hematuria and nephrotic syndrome. Laboratory testing showed mixed cryoglobulinemia and elevated perinuclear anti-neutrophil cytoplasmic (p-ANCA) and myeloperoxidase (MPO) antibodies. SLE-related serologies were negative. Kidney biopsy showed diffuse proliferative global glomerulonephritis with a full-house nephropathy pattern on immunofluorescence suggestive of LN. Due to high...
Source: American Journal of Nephrology - January 27, 2016 Category: Neurology Source Type: research

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature.
We present a case of a 49-year-old female with an atypical presentation of LN who initially presented with new-onset hypertension, edema, arthritis, serositis and recently diagnosed leukocytoclastic vasculitis who later developed acute kidney injury, hematuria and nephrotic syndrome. Laboratory testing showed mixed cryoglobulinemia and elevated perinuclear anti-neutrophil cytoplasmic (p-ANCA) and myeloperoxidase (MPO) antibodies. SLE-related serologies were negative. Kidney biopsy showed diffuse proliferative global glomerulonephritis with a full-house nephropathy pattern on immunofluorescence suggestive of LN. Due to high...
Source: American Journal of Nephrology - January 27, 2016 Category: Urology & Nephrology Authors: Simmons SC, Smith ML, Chang-Miller A, Keddis MT Tags: Am J Nephrol Source Type: research

Novel Stratification of Mortality Risk by Kidney Disease Stage.
CONCLUSION: IMRS is a strong predictor of mortality in patients with CKD and is robustly complementary to CKD stage in refining risk prediction. Given the universal availability and low cost of the CBC and BMP, IMRS may be of a substantial value in CKD risk assessment and management. PMID: 26812216 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 27, 2016 Category: Urology & Nephrology Authors: Rassa AC, Horne BD, McCubrey RO, Bair TL, Muhlestein JB, Morris DR, Anderson JL Tags: Am J Nephrol Source Type: research

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers.
CONCLUSIONS: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. Published by S. Karger AG, Basel. PMID: 26800100 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 23, 2016 Category: Urology & Nephrology Authors: Little DJ, Yuan CM, Thurlow JS, Gounden V, Doi SQ, Pruziner A, Abbott KC, Theeler BJ, Olson SW Tags: Am J Nephrol Source Type: research

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers
Conclusions: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. Published by S. Karger AG, BaselAm J Nephrol 2015;42:436-442 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 22, 2016 Category: Neurology Source Type: research

Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study
Background: Higher dietary acid load can result in metabolic acidosis and is associated with faster kidney disease progression in patients with chronic kidney disease (CKD). However, the relationship between dietary acid load and incident CKD has not been evaluated. Methods: We conducted prospective analyses of the Atherosclerosis Risk in Communities study participants without CKD at baseline (1987-1989, n = 15,055). Dietary acid load was estimated using the equation for potential renal acid load by Remer and Manz, incorporating dietary intake data from a food frequency questionnaire. Incident CKD was assessed from baselin...
Source: American Journal of Nephrology - January 21, 2016 Category: Neurology Source Type: research

Food for Thought: Diet as a Risk Factor for CKD
Am J Nephrol 2015;42:425-426 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2016 Category: Neurology Source Type: research

Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study.
Abstract BACKGROUND: Higher dietary acid load can result in metabolic acidosis and is associated with faster kidney disease progression in patients with chronic kidney disease (CKD). However, the relationship between dietary acid load and incident CKD has not been evaluated. METHODS: We conducted prospective analyses of the Atherosclerosis Risk in Communities study participants without CKD at baseline (1987-1989, n = 15,055). Dietary acid load was estimated using the equation for potential renal acid load by Remer and Manz, incorporating dietary intake data from a food frequency questionnaire. Incident CKD wa...
Source: American Journal of Nephrology - January 21, 2016 Category: Urology & Nephrology Authors: Rebholz CM, Coresh J, Grams ME, Steffen LM, Anderson CA, Appel LJ, Crews DC Tags: Am J Nephrol Source Type: research

Food for Thought: Diet as a Risk Factor for CKD.
PMID: 26789532 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2016 Category: Urology & Nephrology Authors: Chen X, Beddhu S Tags: Am J Nephrol Source Type: research

Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis.
CONCLUSIONS: Our study had demonstrated a favorable test performance and cost efficiency of 2-stage BKV screening. PMID: 26756552 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 13, 2016 Category: Urology & Nephrology Authors: Ma MK, Leung AY, Lo KY, Lio WI, Chan HW, Wong I, Hau AK, Tam CH, Wong AK, Kuok UI, Chau KF, Fung SK, Kwan TH, Wong SS, Tang SC Tags: Am J Nephrol Source Type: research

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine.
CONCLUSION: In conclusion, these results confirmed our hypothesis that protein markers in urinary exosomes better reflected the underlying protein changes in the kidney than in whole urine samples. PMID: 26756605 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 13, 2016 Category: Urology & Nephrology Authors: Gudehithlu KP, Garcia-Gomez I, Vernik J, Brecklin C, Kraus M, Cimbaluk DJ, Hart P, Dunea G, Arruda JA, Singh AK Tags: Am J Nephrol Source Type: research

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study
Background: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and AKI as assessed by neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine (SCr) and kinetic estimated glomerular filtration rate (KeGFR). Results: Patients undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present between SUA and NGAL measured at...
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

Screening Algorithm for BK Virus-Associated Nephropathy Using Sequential Testing of Urinary Cytology: A Probabilistic Model Analysis
Conclusions: Our study had demonstrated a favorable test performance and cost efficiency of 2-stage BKV screening.Am J Nephrol 2015;42:410-417 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine
Conclusion: In conclusion, these results confirmed our hypothesis that protein markers in urinary exosomes better reflected the underlying protein changes in the kidney than in whole urine samples.Am J Nephrol 2015;42:418-424 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 12, 2016 Category: Neurology Source Type: research

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study.
Abstract BACKGROUND: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. METHODS: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and AKI as assessed by neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine (SCr) and kinetic estimated glomerular filtration rate (KeGFR). RESULTS: Patients undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present betw...
Source: American Journal of Nephrology - January 6, 2016 Category: Urology & Nephrology Authors: Ejaz AA, Alquadan KF, Dass B, Shimada M, Kanbay M, Johnson RJ Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 and Vascular Calcification: Is It Set in Stone
Am J Nephrol 2015;42:389-390 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 23, 2015 Category: Neurology Source Type: research

Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus.
Abstract BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. The role of FGF23 in vascular calcification remains controversial. METHODS: Relationships between FGF23 and coronary artery calcified atherosclerotic plaque (CAC), aortoiliac calcified plaque (CP), carotid artery CP, volumetric bone mineral density (vBMD), albuminuria, and estimated glomerular filtration rate (eGFR) were determined in 545 African Americans with type 2 diabetes (T2D) and preserved kidney function in African American-Diabetes Heart Study par...
Source: American Journal of Nephrology - December 23, 2015 Category: Urology & Nephrology Authors: Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 and Vascular Calcification: Is It Set in Stone?
PMID: 26693905 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 23, 2015 Category: Urology & Nephrology Authors: Chan GC, Tang SC Tags: Am J Nephrol Source Type: research

Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus
Background: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. The role of FGF23 in vascular calcification remains controversial. Methods: Relationships between FGF23 and coronary artery calcified atherosclerotic plaque (CAC), aortoiliac calcified plaque (CP), carotid artery CP, volumetric bone mineral density (vBMD), albuminuria, and estimated glomerular filtration rate (eGFR) were determined in 545 African Americans with type 2 diabetes (T2D) and preserved kidney function in African American-Diabetes Heart Study participants. Generalized ...
Source: American Journal of Nephrology - December 22, 2015 Category: Neurology Source Type: research

Fibroblast Growth Factor 23 and Vascular Calcification: Is It Set in Stone?
Am J Nephrol 2015;42:389-390 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2015 Category: Neurology Source Type: research

Treatment of Secondary Hyperparathyroidism: Results of a Phase 2 Trial Evaluating an Intravenous Peptide Agonist of the Calcium-Sensing Receptor.
CONCLUSION: AMG416 was well tolerated and appears to be an effective agent for the treatment of SHPT in patients on hemodialysis. PMID: 26684933 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 19, 2015 Category: Urology & Nephrology Authors: Bushinsky DA, Block GA, Martin KJ, Bell G, Huang S, Sun Y, Spiegel DM, Walsh L, Mix TC, Kewalramani R Tags: Am J Nephrol Source Type: research

Febuxostat Prevents Renal Interstitial Fibrosis by the Activation of BMP-7 Signaling and Inhibition of USAG-1 Expression in Rats
Conclusion: Febuxostat was able to attenuate RIF caused by UUO, which was associated with the activation of BMP-7-Smad1/5/8 pathway and the inhibition of USAG-1 expression in the kidneys of UUO rats.Am J Nephrol 2015;42:369-378 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 18, 2015 Category: Neurology Source Type: research

Treatment of Secondary Hyperparathyroidism: Results of a Phase 2 Trial Evaluating an Intravenous Peptide Agonist of the Calcium-Sensing Receptor
Conclusion: AMG416 was well tolerated and appears to be an effective agent for the treatment of SHPT in patients on hemodialysis.Am J Nephrol 2015;42:379-388 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 18, 2015 Category: Neurology Source Type: research

Febuxostat Prevents Renal Interstitial Fibrosis by the Activation of BMP-7 Signaling and Inhibition of USAG-1 Expression in Rats.
CONCLUSION: Febuxostat was able to attenuate RIF caused by UUO, which was associated with the activation of BMP-7-Smad1/5/8 pathway and the inhibition of USAG-1 expression in the kidneys of UUO rats. PMID: 26680283 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 18, 2015 Category: Urology & Nephrology Authors: Cao J, Li Y, Peng Y, Zhang Y, Li H, Li R, Xia A Tags: Am J Nephrol Source Type: research

Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease
Background: Evidence suggests that the renin-angiotensin-aldosterone system (RAAS) interacts with the vitamin D-fibroblast growth factor 23-Klotho axis. We investigated whether circulating mineral metabolism markers modify outcomes in response to RAAS inhibition in subjects with advanced chronic kidney disease (CKD). Methods: In this retrospective cohort study, we analyzed the association of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) use with all-cause mortality and dialysis initiation among 1,753 subjects (1,099 CKD, estimated glomerular filtration rate 18 ± 6 ml/min/1.73 ...
Source: American Journal of Nephrology - November 26, 2015 Category: Neurology Source Type: research

Prevalence of Hyperkalemia in Diabetic and Non-Diabetic Patients with Chronic Kidney Disease: A Nested Case-Control Study.
CONCLUSIONS: Diabetes mellitus was found to elevate the prevalence of hyperkalemia only in CKD Stage 3 patients (moderately impaired renal function). Advanced CKD at Stage 4 and ACEIs are major determinants of hyperkalemia occurrence. PMID: 26599956 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 25, 2015 Category: Urology & Nephrology Authors: Loutradis C, Tolika P, Skodra A, Avdelidou A, Sarafidis PA Tags: Am J Nephrol Source Type: research

Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease.
Abstract BACKGROUND: Evidence suggests that the renin-angiotensin-aldosterone system (RAAS) interacts with the vitamin D-fibroblast growth factor 23-Klotho axis. We investigated whether circulating mineral metabolism markers modify outcomes in response to RAAS inhibition in subjects with advanced chronic kidney disease (CKD). METHODS: In this retrospective cohort study, we analyzed the association of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) use with all-cause mortality and dialysis initiation among 1,753 subjects (1,099 CKD, estimated glomerular filtration rate 18 ...
Source: American Journal of Nephrology - November 25, 2015 Category: Urology & Nephrology Authors: Jovanovich AJ, Chonchol MB, Sobhi A, Kendrick JB, Cheung AK, Kaufman JS, Smits G, Jablonski KL, and the HOST Investigators Tags: Am J Nephrol Source Type: research

Prevalence of Hyperkalemia in Diabetic and Non-Diabetic Patients with Chronic Kidney Disease: A Nested Case-Control Study
Conclusions: Diabetes mellitus was found to elevate the prevalence of hyperkalemia only in CKD Stage 3 patients (moderately impaired renal function). Advanced CKD at Stage 4 and ACEIs are major determinants of hyperkalemia occurrence.Am J Nephrol 2015;42:351-360 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 25, 2015 Category: Neurology Source Type: research

Intradialytic Blood Pressure Abnormalities: The Highs, The Lows and All That Lies Between
We present evidence associating intradialytic BP phenomena including fall, rise and variability with adverse clinical outcomes and review related pathophysiologic mechanisms and potential management strategies. Summary: Observational studies demonstrate associations between intradialytic hypotension, hypertension and BP variability and mortality. Lack of consensus regarding diagnostic criteria has hampered data synthesis, and prospective studies investigating optimal management strategies for BP phenomena are lacking. Mechanistic data suggest that cardiac, gut, kidney and brain ischemia may lie on the causal pathway betwee...
Source: American Journal of Nephrology - November 21, 2015 Category: Neurology Source Type: research

Intradialytic Blood Pressure Abnormalities: The Highs, The Lows and All That Lies Between.
We present evidence associating intradialytic BP phenomena including fall, rise and variability with adverse clinical outcomes and review related pathophysiologic mechanisms and potential management strategies. SUMMARY: Observational studies demonstrate associations between intradialytic hypotension, hypertension and BP variability and mortality. Lack of consensus regarding diagnostic criteria has hampered data synthesis, and prospective studies investigating optimal management strategies for BP phenomena are lacking. Mechanistic data suggest that cardiac, gut, kidney and brain ischemia may lie on the causal pathway b...
Source: American Journal of Nephrology - November 20, 2015 Category: Urology & Nephrology Authors: Assimon MM, Flythe JE Tags: Am J Nephrol Source Type: research

Impact of Poverty and Health Care Insurance on Arteriovenous Fistula Use among Incident Hemodialysis Patients
Background: The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiated on HD. Methods: In this retrospective cohort study using the United States Renal Data System database, we identified 669,206 patients initiated on maintenance HD from January 1, 2007 through December 31, 2012. We assessed the Medicare-Medicaid dual-eligibility status as an indicator of individual-level pov...
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Oxidative Balance Score and Chronic Kidney Disease
Background: The oxidative balance score (OBS) is a composite estimate of the overall pro- and antioxidant exposure status in an individual. The aim of this study was to determine the association between OBS and renal disease. Methods: Using the Reasons for Geographic and Racial Differences in Stroke cohort study, OBS was calculated by combining 13 a priori-defined pro- and antioxidant factors by using baseline dietary and lifestyle assessment. OBS was divided into quartiles (Q1-Q4) with the lowest quartile, Q1 (predominance of pro-oxidants), as the reference. Multivariable logistic regression and Cox proportional hazards m...
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Antioxidants Therapy for Patients with Chronic Kidney Disease: A Question of Balance
Am J Nephrol 2015;42:318-319 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Oxidative Balance Score and Chronic Kidney Disease.
Abstract BACKGROUND: The oxidative balance score (OBS) is a composite estimate of the overall pro- and antioxidant exposure status in an individual. The aim of this study was to determine the association between OBS and renal disease. METHODS: Using the Reasons for Geographic and Racial Differences in Stroke cohort study, OBS was calculated by combining 13 a priori-defined pro- and antioxidant factors by using baseline dietary and lifestyle assessment. OBS was divided into quartiles (Q1-Q4) with the lowest quartile, Q1 (predominance of pro-oxidants), as the reference. Multivariable logistic regression and Cox...
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Ilori TO, Sun Ro Y, Kong SY, Gutierrez OM, Ojo AO, Judd SE, Narayan KM, Goodman M, Plantinga L, McClellan W Tags: Am J Nephrol Source Type: research

Antioxidants Therapy for Patients with Chronic Kidney Disease: A Question of Balance.
PMID: 26569480 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Chen J, Siriki R Tags: Am J Nephrol Source Type: research

Impact of Poverty and Health Care Insurance on Arteriovenous Fistula Use among Incident Hemodialysis Patients.
Abstract BACKGROUND: The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiated on HD. METHODS: In this retrospective cohort study using the United States Renal Data System database, we identified 669,206 patients initiated on maintenance HD from January 1, 2007 through December 31, 2012. We assessed the Medicare-Medicaid dual-eligibility status as an indicator ...
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Nee R, Moon DS, Jindal RM, Hurst FP, Yuan CM, Agodoa LY, Abbott KC Tags: Am J Nephrol Source Type: research

Clinical Outcomes in Patients with Severe Renal Dysfunction Including Dialysis Following Defibrillator Implantation
Background: Renal dysfunction is associated with increased mortality in heart failure (HF) patients. However, there are limited data regarding clinical and arrhythmic outcomes associated with implantable cardioverter defibrillator (ICD) therapy in this population. Methods: We evaluated outcomes associated with the severity of renal dysfunction with or without dialysis among 2,289 patients who were enrolled and prospectively followed up in the Israeli ICD Registry. The primary endpoint of the study was all-cause mortality. Secondary endpoints included cardiac mortality, HF hospitalization, non-cardiac hospitalization, and a...
Source: American Journal of Nephrology - November 4, 2015 Category: Neurology Source Type: research

Clinical Outcomes in Patients with Severe Renal Dysfunction Including Dialysis Following Defibrillator Implantation.
Abstract BACKGROUND: Renal dysfunction is associated with increased mortality in heart failure (HF) patients. However, there are limited data regarding clinical and arrhythmic outcomes associated with implantable cardioverter defibrillator (ICD) therapy in this population. METHODS: We evaluated outcomes associated with the severity of renal dysfunction with or without dialysis among 2,289 patients who were enrolled and prospectively followed up in the Israeli ICD Registry. The primary endpoint of the study was all-cause mortality. Secondary endpoints included cardiac mortality, HF hospitalization, non-cardiac...
Source: American Journal of Nephrology - October 31, 2015 Category: Urology & Nephrology Authors: Bogdan S, Nof E, Eisen A, Sela R, Rosenheck S, Freedberg N, Geist M, Ben-Zvi S, Haim M, Glikson M, Goldenberg I, Suleiman M, Israeli working group of pacing and electrophysiology of the Israeli Heart Society Tags: Am J Nephrol Source Type: research

Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages.
CONCLUSION: Taken together, our findings show that endotoxemia results in activation of mTOR signaling in macrophages, leading to progressive kidney inflammatory injuries and subsequent fibrosis. Our study may reveal a mechanism involved in the development of sepsis-associated CKD and kidney fibrosis. PMID: 26517816 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 31, 2015 Category: Urology & Nephrology Authors: Chen H, Zhu J, Liu Y, Dong Z, Liu H, Liu Y, Zhou X, Liu F, Chen G Tags: Am J Nephrol Source Type: research

Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages
Conclusion: Taken together, our findings show that endotoxemia results in activation of mTOR signaling in macrophages, leading to progressive kidney inflammatory injuries and subsequent fibrosis. Our study may reveal a mechanism involved in the development of sepsis-associated CKD and kidney fibrosis.Am J Nephrol 2015;42:305-317 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2015 Category: Neurology Source Type: research

Intervention Associated Acute Kidney Injury and Long-Term Cardiovascular Outcomes
Background: Acute kidney injury (AKI) has been associated with all-cause short- and long-term mortality. However, its association with cardiovascular (CV) events remains unclear. We sought to investigate this in patients undergoing open (OAR) or endovascular (EVAR) abdominal aortic aneurysm repair, as they are likely to develop both AKI and CV morbidity. A meta-analysis was subsequently performed to confirm this in other CV-interventions. Methods: AKI-incidence was assessed in a multicentre-cohort of 1,068 patients undergoing EVAR (947 individuals) or OAR electively using the ‘Acute Kidney Injury Network' criteria. A...
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Acute Kidney Injury: A Modifiable Risk Factor for Cardiovascular Morbidity and Mortality
Am J Nephrol 2015;42:282-284 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease
Conclusion: Lifestyle modification is feasible in obese patients with CKD and produces weight loss that is related to improvements in exercise capacity, insulin resistance and adipokines. Whether lifestyle-induced weight loss and fitness can be sustained and whether it will mediate improvements in kidney function over time merits further investigation.Am J Nephrol 2015;42:274-281 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Paricalcitol, Microvascular and Endothelial Function in Non-Diabetic Chronic Kidney Disease: A Randomized Trial
Conclusions: Endothelial function declined significantly over 3 months in patients with moderate CKD, and this decline could be ameliorated by VDRA treatment (NCT01204528).Am J Nephrol 2015;42:265-273 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Association Analysis of the Reticulon 1 Gene in End-Stage Kidney Disease
Conclusions: These results suggest evidence of genetic association between common variants in RTN1 and ESKD in AAs and EAs.Am J Nephrol 2015;42:259-264 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Intervention Associated Acute Kidney Injury and Long-Term Cardiovascular Outcomes.
Abstract BACKGROUND: Acute kidney injury (AKI) has been associated with all-cause short- and long-term mortality. However, its association with cardiovascular (CV) events remains unclear. We sought to investigate this in patients undergoing open (OAR) or endovascular (EVAR) abdominal aortic aneurysm repair, as they are likely to develop both AKI and CV morbidity. A meta-analysis was subsequently performed to confirm this in other CV-interventions. METHODS: AKI-incidence was assessed in a multicentre-cohort of 1,068 patients undergoing EVAR (947 individuals) or OAR electively using the 'Acute Kidney Injury Net...
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Saratzis A, Harrison S, Barratt J, Sayers RD, Sarafidis PA, Bown MJ Tags: Am J Nephrol Source Type: research

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease.
CONCLUSION: Lifestyle modification is feasible in obese patients with CKD and produces weight loss that is related to improvements in exercise capacity, insulin resistance and adipokines. Whether lifestyle-induced weight loss and fitness can be sustained and whether it will mediate improvements in kidney function over time merits further investigation. PMID: 26495987 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Navaneethan SD, Fealy CE, Scelsi AC, Arrigain S, Malin SK, Kirwan JP Tags: Am J Nephrol Source Type: research