Primary and Secondary Thrombotic Microangiopathy Referred to a Single Plasma Exchange Center for Suspected Thrombotic Thrombocytopenic Purpura: 2000-2011.
CONCLUSIONS: In contrast to patients with secondary TTP or HUS, those with primary TTP have a higher refractory and relapse rate, but are also more likely to achieve remission and survive. © 2015 S. Karger AG, Basel. PMID: 26183258 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 14, 2015 Category: Urology & Nephrology Authors: Dahlan R, Sontrop JM, Li L, Ghadieh O, Clark WF Tags: Am J Nephrol Source Type: research

Primary and Secondary Thrombotic Microangiopathy Referred to a Single Plasma Exchange Center for Suspected Thrombotic Thrombocytopenic Purpura: 2000-2011
Conclusions: In contrast to patients with secondary TTP or HUS, those with primary TTP have a higher refractory and relapse rate, but are also more likely to achieve remission and survive.Am J Nephrol 2015;41:429-437 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2015 Category: Neurology Source Type: research

Treatment and Outcome of Primary and Secondary Thrombotic Microangiopathies
Am J Nephrol 2015;41:427-428 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2015 Category: Neurology Source Type: research

Arteriovenous Grafts: Early Ultrasonography Tells Their Fortune
Background: The patency of arteriovenous grafts (AVG) for hemodialysis is mostly limited by growing stenoses that lead to decreasing of blood flow, thromboses and finally to access failure. The aim of this study was to find out if detection of any pathology by duplex Doppler ultrasonography (DDU) early after creation of AVG could identify those with lower survival. Methods: We retrospectively enrolled AVG examined by DDU in our center within 40 days after their creation during the last 10 years. The findings were divided into 4 subgroups: (1a) normal finding, (1b) DDU risk factor (low flow volume, medial calcinosis of the ...
Source: American Journal of Nephrology - July 11, 2015 Category: Neurology Source Type: research

Can We Improve Dialysis Arteriovenous Graft Survival
Am J Nephrol 2015;41:418-419 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 11, 2015 Category: Neurology Source Type: research

Can We Improve Dialysis Arteriovenous Graft Survival?
PMID: 26183377 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 10, 2015 Category: Urology & Nephrology Authors: Karnabatidis D Tags: Am J Nephrol Source Type: research

Arteriovenous Grafts: Early Ultrasonography Tells Their Fortune.
Abstract BACKGROUND: The patency of arteriovenous grafts (AVG) for hemodialysis is mostly limited by growing stenoses that lead to decreasing of blood flow, thromboses and finally to access failure. The aim of this study was to find out if detection of any pathology by duplex Doppler ultrasonography (DDU) early after creation of AVG could identify those with lower survival. METHODS: We retrospectively enrolled AVG examined by DDU in our center within 40 days after their creation during the last 10 years. The findings were divided into 4 subgroups: (1a) normal finding, (1b) DDU risk factor (low flow volume, me...
Source: American Journal of Nephrology - July 10, 2015 Category: Urology & Nephrology Authors: Kudlicka J, Malik J, Tuka V, Chytilova E, Krupickova Z, Grauova B, Vorcakova J, Janak D, Kavan J, Kittnar O, Slavikova M Tags: Am J Nephrol Source Type: research

Kidney Measures with Diabetes and Hypertension on Cardiovascular Disease: The Atherosclerosis Risk in Communities Study
Background: Whether the association of chronic kidney disease (CKD) with cardiovascular risk differs based on diabetes mellitus (DM) and hypertension (HTN) status remains unanswered. Methods: We investigated 11,050 participants from the Atherosclerosis Risk in Communities Study (fourth examination (1996-1998)) with follow-up for cardiovascular outcomes (coronary disease, heart failure and stroke) through 2009. Using the Cox regression models, we quantified cardiovascular risk associated with estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) in individuals with and without DM and/or H...
Source: American Journal of Nephrology - June 30, 2015 Category: Neurology Source Type: research

Kidney Measures with Diabetes and Hypertension on Cardiovascular Disease: The Atherosclerosis Risk in Communities Study.
Abstract BACKGROUND: Whether the association of chronic kidney disease (CKD) with cardiovascular risk differs based on diabetes mellitus (DM) and hypertension (HTN) status remains unanswered. METHODS: We investigated 11,050 participants from the Atherosclerosis Risk in Communities Study (fourth examination (1996-1998)) with follow-up for cardiovascular outcomes (coronary disease, heart failure and stroke) through 2009. Using the Cox regression models, we quantified cardiovascular risk associated with estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) in individuals with ...
Source: American Journal of Nephrology - June 30, 2015 Category: Urology & Nephrology Authors: Alexander N, Matsushita K, Sang Y, Ballew S, Mahmoodi BK, Astor BC, Coresh J Tags: Am J Nephrol Source Type: research

Adverse Effects of Conventional Thrice-Weekly Hemodialysis: Is It Time to Avoid 3-Day Interdialytic Intervals?
This article summarizes currently available epidemiologic and pathophysiologic evidence on the adverse effects related to the long interdialytic interval of thrice-weekly hemodialysis and discusses the need to research further alternative dialysis practices that could mitigate these risks.Am J Nephrol 2015;41:400-408 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 27, 2015 Category: Neurology Source Type: research

Adverse Effects of Conventional Thrice-Weekly Hemodialysis: Is It Time to Avoid 3-Day Interdialytic Intervals?
This article summarizes currently available epidemiologic and pathophysiologic evidence on the adverse effects related to the long interdialytic interval of thrice-weekly hemodialysis and discusses the need to research further alternative dialysis practices that could mitigate these risks. © 2015 S. Karger AG, Basel. PMID: 26139107 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 27, 2015 Category: Urology & Nephrology Authors: Georgianos PI, Sarafidis PA, Sinha AD, Agarwal R Tags: Am J Nephrol Source Type: research

Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning
Conclusions: We propose that transient early hemoglobinuria (associated with oxidative stress) with consecutive late hematuria (associated with anticoagulation) are novel biomarkers of BDF poisoning, and they can be used in clinical setting or in mass casualty with BDF to identify poisoned patients.Am J Nephrol 2015;41:392-399 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 20, 2015 Category: Neurology Source Type: research

Intensive Perioperative Simvastatin Treatment Protects from Chronic Kidney Allograft Injury
Conclusion: Our data suggest that perioperative recipient statin treatment reduces inflammation and may protect the graft in the long term.Am J Nephrol 2015;41:383-391 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 20, 2015 Category: Neurology Source Type: research

Intensive Perioperative Simvastatin Treatment Protects from Chronic Kidney Allograft Injury.
CONCLUSION: Our data suggest that perioperative recipient statin treatment reduces inflammation and may protect the graft in the long term. © 2015 S. Karger AG, Basel. PMID: 26111494 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 20, 2015 Category: Urology & Nephrology Authors: Palin NK, Savikko J, Rintala JM, Koskinen PK Tags: Am J Nephrol Source Type: research

Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning.
CONCLUSIONS: We propose that transient early hemoglobinuria (associated with oxidative stress) with consecutive late hematuria (associated with anticoagulation) are novel biomarkers of BDF poisoning, and they can be used in clinical setting or in mass casualty with BDF to identify poisoned patients. © 2015 S. Karger AG, Basel. PMID: 26111556 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 20, 2015 Category: Urology & Nephrology Authors: Ware KM, Feinstein DL, Rubinstein I, Weinberg G, Rovin BH, Hebert L, Muni N, Cianciolo RE, Satoskar AA, Nadasdy T, Brodsky SV Tags: Am J Nephrol Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis
Conclusions: Our meta-analysis demonstrates an association between TAVR and lower AKI risk.Am J Nephrol 2015;41:372-382 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Neurology Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement
Am J Nephrol 2015;41:370-371 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Neurology Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement.
PMID: 26113253 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Urology & Nephrology Authors: Mohandas R, Anderson RD, Pepine CJ Tags: Am J Nephrol Source Type: research

Acute Kidney Injury after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Our meta-analysis demonstrates an association between TAVR and lower AKI risk. © 2015 S. Karger AG, Basel. PMID: 26113391 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 19, 2015 Category: Urology & Nephrology Authors: Thongprayoon C, Cheungpasitporn W, Srivali N, Ungprasert P, Kittanamongkolchai W, Greason KL, Kashani KB Tags: Am J Nephrol Source Type: research

Interpreting CD56+ and CD163+ Infiltrates in Early versus Late Renal Transplant Biopsies.
CONCLUSIONS: Intragraft CD56+ cell infiltrates were significantly associated with AMR and subsequent poor clinical outcomes. © 2015 S. Karger AG, Basel. PMID: 26087825 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 18, 2015 Category: Urology & Nephrology Authors: Shin S, Kim YH, Cho YM, Park Y, Han S, Choi BH, Choi JY, Han DJ Tags: Am J Nephrol Source Type: research

Interpreting CD56+ and CD163+ Infiltrates in Early versus Late Renal Transplant Biopsies
Conclusions: Intragraft CD56+ cell infiltrates were significantly associated with AMR and subsequent poor clinical outcomes.Am J Nephrol 2015;41:362-369 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 17, 2015 Category: Neurology Source Type: research

Trends in Anemia Management Practices in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Retrospective Cohort Analysis
Conclusions: In patients receiving persistent dialysis, dose and frequency of ESA administrations decreased during the period 2007-2011. Mean hemoglobin levels decreased by more than 1 g/dl, while transfusion rates increased by approximately 25%.Am J Nephrol 2015;41:354-361 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 16, 2015 Category: Neurology Source Type: research

A Pathological Scoring System to Predict Renal Outcome in Diabetic Nephropathy
Conclusion: Prediction of DN patients' renal outcome was better with the D-score than without it. Patients with a D-score ≤14 had excellent renal prognosis.Am J Nephrol 2015;41:337-344 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption
Background: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle dysfunction, which can be applied to study the severity and the reversibility of ESRD myopathy. We tested the hypothesis that deconditioning is a relevant factor in ESRD myopathy. Methods: The whole dialysis population (n = 59) of two of the eight centers participating into the EXCITE study (ClinicalTrials.gov NCT01255969), a randomized trial evaluating the effect of a home-based exerc...
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy
Conclusion: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN.Am J Nephrol 2015;41:345-353 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Estimated Pulmonary Artery Systolic Pressure and Self-Reported Physical Function in Patients on Hemodialysis
Conclusion: Left ventricular hypertrophy and elevated pulmonary pressure are associated with worse self-reported physical function in patients on hemodialysis. The role of chronic volume overload on PASP and PF score should be evaluated in a prospective manner.Am J Nephrol 2015;41:313-319 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 15, 2015 Category: Neurology Source Type: research

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy.
CONCLUSION: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN. © 2015 S. Karger AG, Basel. PMID: 26087695 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 13, 2015 Category: Urology & Nephrology Authors: Xie Q, Li Y, Xue J, Xiong Z, Wang L, Sun Z, Ren Y, Zhu X, Hao CM Tags: Am J Nephrol Source Type: research

Estimated Pulmonary Artery Systolic Pressure and Self-Reported Physical Function in Patients on Hemodialysis.
CONCLUSION: Left ventricular hypertrophy and elevated pulmonary pressure are associated with worse self-reported physical function in patients on hemodialysis. The role of chronic volume overload on PASP and PF score should be evaluated in a prospective manner. © 2015 S. Karger AG, Basel. PMID: 26089100 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 13, 2015 Category: Urology & Nephrology Authors: Abreo AP, Herzog CA, Kutner NG, Lea J, Johansen KL Tags: Am J Nephrol Source Type: research

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption.
ali C Abstract BACKGROUND: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle dysfunction, which can be applied to study the severity and the reversibility of ESRD myopathy. We tested the hypothesis that deconditioning is a relevant factor in ESRD myopathy. METHODS: The whole dialysis population (n = 59) of two of the eight centers participating into the EXCITE study (ClinicalTrials.gov NCT01255969), a randomized trial evaluating the...
Source: American Journal of Nephrology - June 11, 2015 Category: Urology & Nephrology Authors: Manfredini F, Lamberti N, Malagoni AM, Felisatti M, Zuccalà A, Torino C, Tripepi G, Catizone L, Mallamaci F, Zoccali C Tags: Am J Nephrol Source Type: research

A Pathological Scoring System to Predict Renal Outcome in Diabetic Nephropathy.
CONCLUSION: Prediction of DN patients' renal outcome was better with the D-score than without it. Patients with a D-score ≤14 had excellent renal prognosis. © 2015 S. Karger AG, Basel. PMID: 26067713 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 11, 2015 Category: Urology & Nephrology Authors: Hoshino J, Mise K, Ueno T, Imafuku A, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Sawa N, Hara S, Fujii T, Ohashi K, Ubara Y, Takaichi K Tags: Am J Nephrol Source Type: research

Renal Function and Long-Term Decline in Cognitive Function: The Baltimore Longitudinal Study of Aging
Background: Renal disease has been associated with greater risk of dementia and greater cognitive impairment. However, the relationship of lower renal function with long-term decline in specific domains of cognitive function remains unclear among community-dwelling, non-demented individuals. Methods: Stroke- and dementia-free participants (n = 2,116) were enrolled in the Baltimore Longitudinal Study of Aging, a community-based, prospective, longitudinal study. Renal function was estimated by the inverse of serum creatinine adjusted for age, sex and race and (in sensitivity analyses) estimated glomerular filtration rate (eG...
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Aortic Stiffness and Kidney Disease in an Elderly Population
Conclusion: Greater aortic stiffness may be associated with modestly higher levels of albuminuria in the elderly. The association between aortic stiffness and lower eGFR may be confounded by age and CVD risk factors.Am J Nephrol 2015;41:320-328 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Early Kidney Disease, an Important Factor in Cognitive Decline or Merely a Harbinger of Early Vascular Brain Injury?
Am J Nephrol 2015;41:303-304 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Neurology Source Type: research

Early Kidney Disease, an Important Factor in Cognitive Decline or Merely a Harbinger of Early Vascular Brain Injury?
PMID: 26067178 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Urology & Nephrology Authors: Lewis JR Tags: Am J Nephrol Source Type: research

Aortic Stiffness and Kidney Disease in an Elderly Population.
CONCLUSION: Greater aortic stiffness may be associated with modestly higher levels of albuminuria in the elderly. The association between aortic stiffness and lower eGFR may be confounded by age and CVD risk factors. © 2015 S. Karger AG, Basel. PMID: 26067356 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 6, 2015 Category: Urology & Nephrology Authors: Michener KH, Mitchell GF, Noubary F, Huang N, Harris T, Andresdottir MB, Palsson R, Gudnason V, Levey AS Tags: Am J Nephrol Source Type: research

Hemodialysis Patients with Hepatitis C Infection Are Not Receiving the New Antiviral Medications
Am J Nephrol 2015;41:302 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 3, 2015 Category: Neurology Source Type: research

Hemodialysis Patients with Hepatitis C Infection Are Not Receiving the New Antiviral Medications.
PMID: 26044708 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 3, 2015 Category: Urology & Nephrology Authors: Goodkin DA, Bieber B Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab.
CONCLUSION: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide. © 2015 S. Karger AG, Basel. PMID: 26044574 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 2, 2015 Category: Urology & Nephrology Authors: Shah S, Hruskova Z, Segelmark M, Morgan MD, Hogan J, Lee SK, Dale J, Harper L, Tesar V, Jayne DR, Geetha D Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab
Conclusion: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide.Am J Nephrol 2015;41:296-301 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2015 Category: Neurology Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States.
CONCLUSIONS: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society. © 2015 S. Karger AG, Basel. PMID: 26044456 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 30, 2015 Category: Urology & Nephrology Authors: Moradi H, Abhari P, Streja E, Kashyap ML, Shah G, Gillen D, Pahl MV, Vaziri ND, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States
Conclusions: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society.Am J Nephrol 2015;41:284-295 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2015 Category: Neurology Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients
Conclusion: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN.Am J Nephrol 2015;41:277-283 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future
Am J Nephrol 2015;41:275-276 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future?
PMID: 26021407 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: White K Tags: Am J Nephrol Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients.
CONCLUSION: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN. © 2015 S. Karger AG, Basel. PMID: 26021523 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: Harindhanavudhi T, Parks A, Mauer M, Caramori ML Tags: Am J Nephrol Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study
Background and Objectives: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 20, 2015 Category: Neurology Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study.
Abstract BACKGROUND AND OBJECTIVES: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR)
Source: American Journal of Nephrology - May 20, 2015 Category: Urology & Nephrology Authors: Foster MC, Hwang SJ, Massaro JM, Jacques PF, Fox CS, Chu AY Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells.
CONCLUSION: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy. © 2015 S. Karger AG, Basel. PMID: 25924590 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2015 Category: Urology & Nephrology Authors: Cheng M, Liu H, Zhang D, Liu Y, Wang C, Liu F, Chen J Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells
Conclusion: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy.Am J Nephrol 2015;41:257-266 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 27, 2015 Category: Neurology Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus.
CONCLUSION: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations. © 2015 S. Karger AG, Basel. PMID: 25926050 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Orjuela A, Suwanichkul A, Canter D, Minard CG, Devaraj S, Hicks MJ, Muscal E, Wenderfer SE Tags: Am J Nephrol Source Type: research