The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature
Background: The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance.Summary: The mechanism for MR activation in tissu...
Source: American Journal of Nephrology - October 10, 2017 Category: Neurology Source Type: research

Patiromer Lowers Serum Potassium When Taken < b > < i > without Food < /i > < /b > : Comparison to Dosing < b > < i > with Food < /i > < /b > from an Open-Label, Randomized, Parallel Group Hyperkalemia Study
Background: Patiromer is a sodium-free, nonabsorbed, potassium binder approved for treatment of hyperkalemia. This open-label study compares the efficacy and safety of patiromer administeredwithout food versuswith food.Methods: Adults with hyperkalemia (potassium ≥5.0 mEq/L) were randomized (1:1) to receive patiromer once dailywithout food orwith food for 4 weeks. The dosage was adjusted (maximum: 25.2 g/day) using a prespecified titration schedule to achieve and maintain potassium within a target range (3.8-5.0 mEq/L). The primary efficacy endpoint was the proportion of patients with serum potassium in the target range...
Source: American Journal of Nephrology - October 10, 2017 Category: Neurology Source Type: research

High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway.
CONCLUSIONS: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF-κB signaling pathway, and the targeted intervention of the TLR4/NF-κB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT. PMID: 29017152 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 10, 2017 Category: Urology & Nephrology Authors: Liu H, Xiong J, He T, Xiao T, Li Y, Yu Y, Huang Y, Xu X, Huang Y, Zhang J, Zhang B, Zhao J Tags: Am J Nephrol Source Type: research

Effectiveness of IHD with Adsorptive PMMA Membrane in Myeloma Cast Nephropathy: A Cohort Study.
CONCLUSION: In patients with dialysis-dependent myeloma cast nephropathy, early FLC removal by IHD-PMMA combined with chemotherapy was associated with high rates of renal recovery and survival. PMID: 29017155 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 10, 2017 Category: Urology & Nephrology Authors: Sens F, Chaintreuil D, Jolivot A, Guebre-Egziabher F, Robinson P, Karlin L, Bridoux F, Juillard L Tags: Am J Nephrol Source Type: research

The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature.
Abstract BACKGROUND: The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance. SUMMARY: The mechanism fo...
Source: American Journal of Nephrology - October 10, 2017 Category: Urology & Nephrology Authors: Belden Z, Deiuliis JA, Dobre M, Rajagopalan S Tags: Am J Nephrol Source Type: research

The Importance of a "Just Right" Serum Potassium Level.
The Importance of a "Just Right" Serum Potassium Level. Am J Nephrol. 2017;46(3):210-212 Authors: Mehta A, Emmett M PMID: 28950266 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 28, 2017 Category: Urology & Nephrology Authors: Mehta A, Emmett M Tags: Am J Nephrol Source Type: research

Association of Serum Amyloid A with Kidney Outcomes and All-Cause Mortality in American Indians with Type 2 Diabetes.
CONCLUSIONS: Higher circulating SAA concentration is associated with a reduced risk of ESRD in American Indians with type 2 diabetes. PMID: 28934744 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 22, 2017 Category: Urology & Nephrology Authors: Saulnier PJ, Dieter BP, Tanamas SK, McPherson SM, Wheelock KM, Knowler WC, Looker HC, Meek RL, Nelson RG, Tuttle KR Tags: Am J Nephrol Source Type: research

Association of Serum Amyloid A with Kidney Outcomes and All-Cause Mortality in American Indians with Type 2 Diabetes
Conclusions: Higher circulating SAA concentration is associated with a reduced risk of ESRD in American Indians with type 2 diabetes.Am J Nephrol 2017;46:276-284 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 21, 2017 Category: Neurology Source Type: research

Cigarette Smoking Attenuates Kidney Protection by Angiotensin-Converting Enzyme Inhibition in Nondiabetic Chronic Kidney Disease.
Abstract BACKGROUND: Cigarette smoking exacerbates the estimated glomerular filtration rate (eGFR) decline in nondiabetic chronic kidney disease (CKD) despite the kidney protection that is achieved by angiotensin converting enzyme inhibition (ACEI). Whether smoking cessation restores ACEI-related kidney protection is not known. METHODS: This 5-year, prospective, prevention trial recruited 108 smokers and 108 nonsmokers with stage-2 nondiabetic CKD with primary hypertension and urine albumin-to-creatinine ratio (Ualb)>200 mg/g. All smokers underwent smoking cessation intervention programs. Blood pressure wa...
Source: American Journal of Nephrology - September 21, 2017 Category: Urology & Nephrology Authors: Roehm B, Simoni J, Pruszynski J, Wesson DE Tags: Am J Nephrol Source Type: research

Vascular Access Placement Order and Outcomes in Hemodialysis Patients: A Longitudinal Study.
CONCLUSIONS: HD vascular access outcomes differ based on the sequence of placement. In spite of frequent AVA placements, only half of patients effectively achieved a "permanent" vascular access and used an AVA for the majority of HD treatments. PMID: 28930719 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 21, 2017 Category: Urology & Nephrology Authors: Murea M, Brown WM, Divers J, Moossavi S, Robinson TW, Bagwell B, Burkart JM, Freedman BI Tags: Am J Nephrol Source Type: research

Tobacco Use: A Chronic Kidney Disease Accelerant.
PMID: 28930748 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 21, 2017 Category: Urology & Nephrology Authors: Leonberg-Yoo AK, Rudnick MR Tags: Am J Nephrol Source Type: research

Cigarette Smoking Attenuates Kidney Protection by Angiotensin-Converting Enzyme Inhibition in Nondiabetic Chronic Kidney Disease
Background: Cigarette smoking exacerbates the estimated glomerular filtration rate (eGFR) decline in nondiabetic chronic kidney disease (CKD) despite the kidney protection that is achieved by angiotensin converting enzyme inhibition (ACEI). Whether smoking cessation restores ACEI-related kidney protection is not known.Methods: This 5-year, prospective, prevention trial recruited 108 smokers and 108 nonsmokers with stage-2 nondiabetic CKD with primary hypertension and urine albumin-to-creatinine ratio (Ualb)>200 mg/g. All smokers underwent smoking cessation intervention programs. Blood pressure was reduced in all partici...
Source: American Journal of Nephrology - September 20, 2017 Category: Neurology Source Type: research

Vascular Access Placement Order and Outcomes in Hemodialysis Patients: A Longitudinal Study
Conclusions:HD vascular access outcomes differ based on the sequence of placement. In spite of frequent AVA placements, only half of patients effectively achieved a “permanent” vascular access and used an AVA for the majority of HD treatments.Am J Nephrol 2017;46:268-275 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2017 Category: Neurology Source Type: research

Tobacco Use: A Chronic Kidney Disease Accelerant
Am J Nephrol 2017;46:257-259 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2017 Category: Neurology Source Type: research

Warfarin Use and Increased Mortality in End-Stage Renal Disease.
In this study, we assessed mortality and cardiovascular outcomes associated with warfarin treatment in patients with stages 3-5 CKD and ESRD admitted to the University of California-Irvine Medical Center. METHODS: In a retrospective matched cohort study, we identified 59 adult patients with stages 3-6 CKD initiated on warfarin during the period 2011-2013, and 144 patients with stages 3-6 CKD who had indications for anticoagulation therapy but were not initiated on warfarin. All-cause mortality risk associated with warfarin treatment was estimated using Cox proportional hazard regression analysis, and the risk of signi...
Source: American Journal of Nephrology - September 15, 2017 Category: Urology & Nephrology Authors: Lin MC, Streja E, Soohoo M, Hanna M, Savoj J, Kalantar-Zadeh K, Lau WL Tags: Am J Nephrol Source Type: research

Warfarin Use and Increased Mortality in End-Stage Renal Disease
In this study, we assessed mortality and cardiovascular outcomes associated with warfarin treatment in patients with stages 3-5 CKD and ESRD admitted to the University of California-Irvine Medical Center.Methods: In a retrospective matched cohort study, we identified 59 adult patients with stages 3-6 CKD initiated on warfarin during the period 2011-2013, and 144 patients with stages 3-6 CKD who had indications for anticoagulation therapy but were not initiated on warfarin. All-cause mortality risk associated with warfarin treatment was estimated using Cox proportional hazard regression analysis, and the risk of significant...
Source: American Journal of Nephrology - September 14, 2017 Category: Neurology Source Type: research

Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.
CONCLUSIONS: In ANCA-associated GN, the interstitial infiltrate contains mainly T lymphocytes. However, it is neither reflecting baseline renal function nor predictive of response to treatment, regardless of the immunosuppression regimen employed. PMID: 28881339 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 8, 2017 Category: Urology & Nephrology Authors: Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC, RAVE-ITN Research Group Tags: Am J Nephrol Source Type: research

The Association of Combined Total Kidney and Liver Volume with Pain and Gastrointestinal Symptoms in Patients with Later Stage Autosomal Dominant Polycystic Kidney Disease.
CONCLUSIONS: This study indicates that combined kidney and liver volume was associated with the presence and severity of pain and GI symptoms in ADPKD, with a more prominent role for hTLV than for hTKV. PMID: 28881341 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 8, 2017 Category: Urology & Nephrology Authors: D'Agnolo HMA, Casteleijn NF, Gevers TJG, de Fijter H, van Gastel MDA, Messchendorp AL, Peters DJM, Salih M, Soonawala D, Spithoven EM, Visser FW, Wetzels JFM, Zietse R, Gansevoort RT, Drenth JPH Tags: Am J Nephrol Source Type: research

Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis
Conclusions: In ANCA-associated GN, the interstitial infiltrate contains mainly T lymphocytes. However, it is neither reflecting baseline renal function nor predictive of response to treatment, regardless of the immunosuppression regimen employed.Am J Nephrol 2017;46:231-238 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2017 Category: Neurology Source Type: research

The Association of Combined Total Kidney and Liver Volume with Pain and Gastrointestinal Symptoms in Patients with Later Stage Autosomal Dominant Polycystic Kidney Disease
Conclusions: This study indicates that combined kidney and liver volume was associated with the presence and severity of pain and GI symptoms in ADPKD, with a more prominent role for hTLV than for hTKV.Am J Nephrol 2017;46:239-248 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 7, 2017 Category: Neurology Source Type: research

Uremic Restless Legs Syndrome Pleads "Not Guilty".
Uremic Restless Legs Syndrome Pleads "Not Guilty". Am J Nephrol. 2017 Sep 05;46(3):222-223 Authors: Sakkas GK PMID: 28869930 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2017 Category: Urology & Nephrology Authors: Sakkas GK Tags: Am J Nephrol Source Type: research

Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study.
CONCLUSIONS: Our study suggests that mortality in ESRD patients is not influenced by concomitant RLS/WED. After a 15-year follow-up, survival rates in our cohort were significantly longer in uremic subjects with RLS/WED than in those without RLS/WED. Finally, we found no relationship between RLS/WED severity and mortality. PMID: 28869939 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2017 Category: Urology & Nephrology Authors: Baiardi S, Mondini S, Baldi Antognini A, Santoro A, Cirignotta F Tags: Am J Nephrol Source Type: research

The Importance of a “Just Right” Serum Potassium Level
Am J Nephrol 2017;46:210-212 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2017 Category: Neurology Source Type: research

Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study
Conclusions: Our study suggests that mortality in ESRD patients is not influenced by concomitant RLS/WED. After a 15-year follow-up, survival rates in our cohort were significantly longer in uremic subjects with RLS/WED than in those without RLS/WED. Finally, we found no relationship between RLS/WED severity and mortality.Am J Nephrol 2017;46:224-230 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2017 Category: Neurology Source Type: research

Uremic Restless Legs Syndrome Pleads “Not Guilty”
Am J Nephrol 2017;46:222-223 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2017 Category: Neurology Source Type: research

Association of Serum Potassium with All-Cause Mortality in Patients with and without Heart Failure, Chronic Kidney Disease, and/or Diabetes.
We examined the association between all-cause mortality and potassium using a cubic spline regression analysis in the total population, a control group, and in HF, CKD, DM, and a combined cohort. RESULTS: 27.6% had a potassium
Source: American Journal of Nephrology - September 2, 2017 Category: Urology & Nephrology Authors: Collins AJ, Pitt B, Reaven N, Funk S, McGaughey K, Wilson D, Bushinsky DA Tags: Am J Nephrol Source Type: research

Association of Serum Potassium with All-Cause Mortality in Patients with and without Heart Failure, Chronic Kidney Disease, and/or Diabetes
We examined the association between all-cause mortality and potassium using a cubic spline regression analysis in the total population, a control group, and in HF, CKD, DM, and a combined cohort.Results: 27.6% had a potassium (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 1, 2017 Category: Neurology Source Type: research

Independent Risk Factors and 2-Year Outcomes of Acute Kidney Injury after Surgery for Congenital Heart Disease.
Abstract BACKGROUND: Data are limited regarding risk factors for acute kidney injury (AKI) following cardiac surgery in children with congenital heart disease (CHD). This observational study was performed to examine temporal trends in AKI incidence according to the Pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease (pRIFLE) criteria, identify independent risk factors for AKI after cardiac surgery, and examine associations between AKI and long-term mortality. METHODS: We retrospectively evaluated 418 patients (259 males, 159 females; median age, 5 months) who underwent cardiac surgery for CHD betwe...
Source: American Journal of Nephrology - September 1, 2017 Category: Urology & Nephrology Authors: Hirano D, Ito A, Yamada A, Kakegawa D, Miwa S, Umeda C, Chiba K, Takemasa Y, Tokunaga A, Ida H Tags: Am J Nephrol Source Type: research

Association between Testosterone and Mortality Risk among U.S. Males Receiving Dialysis.
We examined a nationally representative cohort of male dialysis patients from a large US dialysis organization who underwent one or more total testosterone measurements from 1/2007 to 12/2011. The association between total testosterone categorized as quartiles and all-cause mortality was studied using Cox models adjusted for expanded case-mix and laboratory covariates. We also examined total testosterone as a continuous predictor of all-cause mortality using restricted cubic splines. RESULTS: Among 624 male dialysis patients, 51% of patients demonstrated testosterone deficiency (total testosterone
Source: American Journal of Nephrology - September 1, 2017 Category: Urology & Nephrology Authors: Yu J, Ravel VA, You AS, Streja E, Rivara MB, Potukuchi PK, Brunelli SM, Kovesdy CP, Kalantar-Zadeh K, Rhee CM Tags: Am J Nephrol Source Type: research

Independent Risk Factors and 2-Year Outcomes of Acute Kidney Injury after Surgery for Congenital Heart Disease
Background:Data are limited regarding risk factors for acute kidney injury (AKI) following cardiac surgery in children with congenital heart disease (CHD). This observational study was performed to examine temporal trends in AKI incidence according to the Pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease (pRIFLE) criteria, identify independent risk factors for AKI after cardiac surgery, and examine associations between AKI and long-term mortality.Methods: We retrospectively evaluated 418 patients (259 males, 159 females; median age, 5 months) who underwent cardiac surgery for CHD between April 2007 and August ...
Source: American Journal of Nephrology - August 31, 2017 Category: Neurology Source Type: research

Association between Testosterone and Mortality Risk among U.S. Males Receiving Dialysis
We examined a nationally representative cohort of male dialysis patients from a large US dialysis organization who underwent one or more total testosterone measurements from 1/2007 to 12/2011. The association between total testosterone categorized as quartiles and all-cause mortality was studied using Cox models adjusted for expanded case-mix and laboratory covariates. We also examined total testosterone as a continuous predictor of all-cause mortality using restricted cubic splines.Results: Among 624 male dialysis patients, 51% of patients demonstrated testosterone deficiency (total testosterone (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 31, 2017 Category: Neurology Source Type: research

Quantification of Interstitial Fibrosis in Renal Allografts and Clinical Correlates of Long-Term Graft Function.
CONCLUSIONS: A correlation was not found between %IF and Banff code scores. Greater increases in %IF within 1 year post transplantation may influence long-term graft survival. Computer-analyzed increases in %IF at 1 year may be a surrogate marker for long-term graft function. PMID: 28848141 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 22, 2017 Category: Urology & Nephrology Authors: Nara M, Komatsuda A, Numakura K, Saito M, Inoue T, Niioka T, Miura M, Mitobe Y, Okuyama S, Takahashi N, Habuchi T, Satoh S Tags: Am J Nephrol Source Type: research

Quantification of Interstitial Fibrosis in Renal Allografts and Clinical Correlates of Long-Term Graft Function
Conclusions: A correlation was not found between %IF and Banff code scores. Greater increases in %IF within 1 year post transplantation may influence long-term graft survival. Computer-analyzed increases in %IF at 1 year may be a surrogate marker for long-term graft function.Am J Nephrol 2017;46:187-194 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 21, 2017 Category: Neurology Source Type: research

Health Disparities in Kidney Transplantation for African Americans.
Abstract BACKGROUND: The persistent challenges of bridging healthcare disparities for African Americans (AAs) in need of kidney transplantation continue to be unresolved at the national level. This healthcare disparity is multifactorial: stemming from limited kidney donors suitable for AAs; inconsistent care coordination and suboptimal risk factor control; social determinants, low socioeconomic status, reduced access to care; and mistrust of clinicians and the healthcare system. SUMMARY: There are numerous opportunities to significantly lessen the disparities in kidney transplantation for AAs through the foll...
Source: American Journal of Nephrology - August 5, 2017 Category: Urology & Nephrology Authors: Harding K, Mersha TB, Pham PT, Waterman AD, Webb FA, Vassalotti JA, Nicholas SB Tags: Am J Nephrol Source Type: research

Current State and Future Trends to Optimize the Care of Chronic Kidney Disease in African Americans.
Abstract BACKGROUND: African Americans (AAs) suffer the widest gaps in chronic kidney disease (CKD) outcomes compared to Caucasian Americans (CAs) and this is because of the disparities that exist in both health and healthcare. In fact, the prevalence of CKD is 3.5 times higher in AAs compared to CAs. The disparities exist at all stages of CKD. Importantly, AAs are 10 times more likely to develop hypertension-related kidney failure and 3 times more likely to progress to kidney failure compared to CAs. SUMMARY: Several factors contribute to these disparities including genetic and social determinants, late refe...
Source: American Journal of Nephrology - August 5, 2017 Category: Urology & Nephrology Authors: Harding K, Mersha TB, Vassalotti JA, Webb FA, Nicholas SB Tags: Am J Nephrol Source Type: research

Current State and Future Trends to Optimize the Care of African Americans with End-Stage Renal Disease.
Abstract BACKGROUND: Chronic kidney disease is a progressive disease, which terminates in end-stage renal diseases (ESRD) that requires either dialysis or kidney transplantation for the patient to survive. There is an alarming trend in the disparities of ESRD in African Americans (AAs). Currently, AAs represent more than 30% of incident ESRD cases, yet they constitute 15% of the overall US population. Despite the reductions in mortality, increases in access to patient-centered home dialysis and preemptive kidney transplantation for the overall US ESRD population over the last decade, disparities in the care of AAs...
Source: American Journal of Nephrology - August 5, 2017 Category: Urology & Nephrology Authors: Harding K, Mersha TB, Webb FA, Vassalotti JA, Nicholas SB Tags: Am J Nephrol Source Type: research

Current State and Future Trends to Optimize the Care of Chronic Kidney Disease in African Americans
Background: African Americans (AAs) suffer the widest gaps in chronic kidney disease (CKD) outcomes compared to Caucasian Americans (CAs) and this is because of the disparities that exist in both health and healthcare. In fact, the prevalence of CKD is 3.5 times higher in AAs compared to CAs. The disparities exist at all stages of CKD. Importantly, AAs are 10 times more likely to develop hypertension-related kidney failure and 3 times more likely to progress to kidney failure compared to CAs.Summary: Several factors contribute to these disparities including genetic and social determinants, late referrals, poor care coordin...
Source: American Journal of Nephrology - August 4, 2017 Category: Neurology Source Type: research

Health Disparities in Kidney Transplantation for African Americans
Background: The persistent challenges of bridging healthcare disparities for African Americans (AAs) in need of kidney transplantation continue to be unresolved at the national level. This healthcare disparity is multifactorial: stemming from limited kidney donors suitable for AAs; inconsistent care coordination and suboptimal risk factor control; social determinants, low socioeconomic status, reduced access to care; and mistrust of clinicians and the healthcare system.Summary: There are numerous opportunities to significantly lessen the disparities in kidney transplantation for AAs through the following measures: the adop...
Source: American Journal of Nephrology - August 4, 2017 Category: Neurology Source Type: research

Current State and Future Trends to Optimize the Care of African Americans with End-Stage Renal Disease
Background: Chronic kidney disease is a progressive disease, which terminates in end-stage renal diseases (ESRD) that requires either dialysis or kidney transplantation for the patient to survive. There is an alarming trend in the disparities of ESRD in African Americans (AAs). Currently, AAs represent more than 30% of incident ESRD cases, yet they constitute 15% of the overall US population. Despite the reductions in mortality, increases in access to patient-centered home dialysis and preemptive kidney transplantation for the overall US ESRD population over the last decade, disparities in the care of AAs with ESRD remain ...
Source: American Journal of Nephrology - August 4, 2017 Category: Neurology Source Type: research

Impact of Renin-Angiotensin Aldosterone System Inhibition on Serum Potassium Levels among Peritoneal Dialysis Patients
Conclusion: The use of ACEi and ARB was not associated with a greater risk for hyperkalemia in stable peritoneal dialysis patients independently of residual renal function.Am J Nephrol 2017;46:150-155 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 24, 2017 Category: Neurology Source Type: research

Review of Extracorporeal Membrane Oxygenation and Dialysis-Based Liver Support Devices for the Use of Nephrologists.
This article provides a simplified review of the technical aspects of extracorporeal cardiopulmonary and liver support devices used in the adult ICU patient, as well as a summary of the most relevant and up-to-date clinical evidence that supports their use. PMID: 28738354 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 22, 2017 Category: Urology & Nephrology Authors: Hamdi T, Palmer BF Tags: Am J Nephrol Source Type: research

Impact of Renin-Angiotensin Aldosterone System Inhibition on Serum Potassium Levels among Peritoneal Dialysis Patients.
CONCLUSION: The use of ACEi and ARB was not associated with a greater risk for hyperkalemia in stable peritoneal dialysis patients independently of residual renal function. PMID: 28738355 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 22, 2017 Category: Urology & Nephrology Authors: Ribeiro SC, Figueiredo AE, Barretti P, Pecoits-Filho R, de Moraes TP, BRAZPD Investigators Tags: Am J Nephrol Source Type: research

Review of Extracorporeal Membrane Oxygenation and Dialysis-Based Liver Support Devices for the Use of Nephrologists
This article provides a simplified review of the technical aspects of extracorporeal cardiopulmonary and liver support devices used in the adult ICU patient, as well as a summary of the most relevant and up-to-date clinical evidence that supports their use.Am J Nephrol 2017;46:139-149 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 21, 2017 Category: Neurology Source Type: research

Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction.
CONCLUSION: These findings suggest that the participation of necroptosis in UUO is partly demonstrated. And necroptosis inhibition may have a potential role in the treatment of diseases with increased inflammatory response and interstitial fibrosis in renal. PMID: 28723681 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 20, 2017 Category: Urology & Nephrology Authors: Xiao X, Du C, Yan Z, Shi Y, Duan H, Ren Y Tags: Am J Nephrol Source Type: research

Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction
Conclusion: These findings suggest that the participation of necroptosis in UUO is partly demonstrated. And necroptosis inhibition may have a potential role in the treatment of diseases with increased inflammatory response and interstitial fibrosis in renal.Am J Nephrol 2017;46:131-138 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 19, 2017 Category: Neurology Source Type: research

Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease.
PMID: 28715823 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 19, 2017 Category: Urology & Nephrology Authors: Sharma K Tags: Am J Nephrol Source Type: research

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients.
Abstract BACKGROUND: Higher serum ferritin levels may be influenced by iron use and inflammation, and are associated with higher mortality in hemodialysis (HD) patients. We hypothesized that a major rise in serum ferritin is associated with a higher risk of mortality, irrespective of baseline serum ferritin in incident HD patients. METHODS: In a cohort of 93,979 incident HD patients between 2007 and 2011, we examined the association of change in serum ferritin from the baseline patient quarter (first 91 days from dialysis start) to the subsequent quarter with mortality. Multivariable adjustments were done for...
Source: American Journal of Nephrology - July 14, 2017 Category: Urology & Nephrology Authors: Kim T, Streja E, Soohoo M, Rhee CM, Eriguchi R, Kim TW, Chang TI, Obi Y, Kovesdy CP, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Dialysis in the Elderly and Impact of Institutionalization in the United States Renal Data System.
CONCLUSION: There was increased mortality in institutionalized elderly patients as compared to noninstutionalized elderly patients in the same age group. In accordance with the increased frailty and decreased benefits of therapies in the very elderly, especially in those with additional co-morbidities besides age, palliative and end-of-life care should be considered. PMID: 28704826 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 14, 2017 Category: Urology & Nephrology Authors: Brar A, Mallappallil M, Stefanov DG, Kau D, Salifu MO Tags: Am J Nephrol Source Type: research

Serum Ferritin Variations and Mortality in Incident Hemodialysis Patients
Background: Higher serum ferritin levels may be influenced by iron use and inflammation, and are associated with higher mortality in hemodialysis (HD) patients. We hypothesized that a major rise in serum ferritin is associated with a higher risk of mortality, irrespective of baseline serum ferritin in incident HD patients.Methods: In a cohort of 93,979 incident HD patients between 2007 and 2011, we examined the association of change in serum ferritin from the baseline patient quarter (first 91 days from dialysis start) to the subsequent quarter with mortality. Multivariable adjustments were done for case-mix and markers of...
Source: American Journal of Nephrology - July 13, 2017 Category: Neurology Source Type: research

Dialysis in the Elderly and Impact of Institutionalization in the United States Renal Data System
Conclusion: There was increased mortality in institutionalized elderly patients as compared to noninstutionalized elderly patients in the same age group. In accordance with the increased frailty and decreased benefits of therapies in the very elderly, especially in those with additional co-morbidities besides age, palliative and end-of-life care should be considered.Am J Nephrol 2017;46:114-119 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2017 Category: Neurology Source Type: research