Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials.
Abstract BACKGROUND: Regression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials. METHODS: This was a post hoc observational cohort study. We hypothesized LVH regression with frequent HD was associated with a different cardiovascular biomarker profile. Regressors were defined as patients who achieved a reduction of more than 10% in LVM at 12 months. Progressors were defined as patients who had a minimum of 10% increase in L...
Source: American Journal of Nephrology - April 5, 2018 Category: Urology & Nephrology Authors: Chan CT, Kaysen GA, Beck GJ, Li M, Lo J, Rocco MV, Kliger AS, FHN Trials Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline.
CONCLUSION: Higher FGF-23 concentrations were not consistently associated with decline in kidney function or incident CKD in community-dwelling older adults. PMID: 29621752 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 5, 2018 Category: Urology & Nephrology Authors: Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle A, Fried L, Sarnak MJ, Gutierrez OM Tags: Am J Nephrol Source Type: research

Nail in the Coffin for Fibroblast Growth Factor 23 as a Predictor of Kidney Function Decline
Am J Nephrol 2018;47:239 –241 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2018 Category: Neurology Source Type: research

Nail in the Coffin for Fibroblast Growth Factor 23 as a Predictor of Kidney Function Decline.
PMID: 29614496 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 3, 2018 Category: Urology & Nephrology Authors: Jovanovich AJ, Chonchol MB Tags: Am J Nephrol Source Type: research

Hypoxia-Inducible Factor 1 α (HIF-1α), Angiopoietin-2 (ANG-2) and Endocan: Novel Biomarkers of Disease Progression Involving Polycystic Kidney Disease
Am J Nephrol 2018;47:228 –230 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 29, 2018 Category: Neurology Source Type: research

Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function
Conclusions: This study suggests that endothelial dysfunction causing microcirculatory changes, linked to angiogenesis and hypoxia, may come early in the course of ADPKD and could be a key regulator of renal injury progression.Am J Nephrol 2018;47:231 –238 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 29, 2018 Category: Neurology Source Type: research

Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function.
This study investigated the levels of emerging biomarkers of endothelial function, angiogenesis and hypoxia, in ADPKD patients with different renal function. METHODS: The study population consisted of three groups: 26 ADPKD patients with impaired renal function (Group A; estimated glomerular filtration rate [eGFR] 45-70 mL/min/1.73 m2), 26 ADPKD patients with preserved renal function (Group B; eGFR>70 mL/min/1.73 m2), and 26 age- and sex-matched controls with no history of renal disease. Circulating levels of endocan (endothelial cell-specific molecule-1) angiopoietin-2, and hypoxia-inducible factor-1a (HIF-1a) wer...
Source: American Journal of Nephrology - March 29, 2018 Category: Urology & Nephrology Authors: Raptis V, Bakogiannis C, Loutradis C, Boutou AK, Lampropoulou I, Intzevidou E, Sioulis A, Balaskas E, Sarafidis PA Tags: Am J Nephrol Source Type: research

Hypoxia-Inducible Factor 1 α (HIF-1α), Angiopoietin-2 (ANG-2) and Endocan: Novel Biomarkers of Disease Progression Involving Polycystic Kidney Disease.
Hypoxia-Inducible Factor 1α (HIF-1α), Angiopoietin-2 (ANG-2) and Endocan: Novel Biomarkers of Disease Progression Involving Polycystic Kidney Disease. Am J Nephrol. 2018 Mar 29;47(4):228-230 Authors: Rahbari-Oskoui FF, Chapman AB PMID: 29597208 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 29, 2018 Category: Urology & Nephrology Authors: Rahbari-Oskoui FF, Chapman AB Tags: Am J Nephrol Source Type: research

Pregnancy Outcomes in French Hemodialysis Patients
Conclusions: Our study is one of the largest series of ­pregnancies in HD patients. Despite recent progresses, these pregnancies remain at high risk, reinforcing the need for an early nephrologist-obstetrician skilled team co-management.Am J Nephrol 2018;47:219 –227 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 27, 2018 Category: Neurology Source Type: research

Pregnancy Outcomes in French Hemodialysis Patients.
CONCLUSIONS: Our study is one of the largest series of -pregnancies in HD patients. Despite recent progresses, these pregnancies remain at high risk, reinforcing the need for an early nephrologist-obstetrician skilled team co-management. PMID: 29587251 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 27, 2018 Category: Urology & Nephrology Authors: Normand G, Xu X, Panaye M, Jolivot A, Lemoine S, Guebre-Egziabher F, Decullier E, Bin S, Doret M, Juillard L Tags: Am J Nephrol Source Type: research

Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease
Conclusions: Remote CKD care delivered through telenephrology improves renal clinic visit adherence while delivering comparable renal outcomes. Application of this technology is a promising method to provide access to care to rural CKD patients and to minimize the disparity between urban/rural patients.Am J Nephrol 2018;47:200 –207 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 20, 2018 Category: Neurology Source Type: research

Telenephrology: Providing Healthcare to Remotely Located Patients with Chronic Kidney Disease.
Abstract BACKGROUND: Chronic kidney disease (CKD) patients who live far (>30 miles) from their nephrologist experience lower rates of clinic visit adherence, limited access to treatment, and higher rates of hospitalization and mortality than patients who live in close proximity to their nephrologist. Strategies to minimize disparities between urban and remotely located CKD patients are needed. The purpose of this study was to determine whether adherence to clinic visits and clinical outcomes in the remote management of CKD via telenephrology is comparable to in-person conventional care. METHODS: Renal clin...
Source: American Journal of Nephrology - March 20, 2018 Category: Urology & Nephrology Authors: Tan J, Mehrotra A, Nadkarni GN, He JC, Langhoff E, Post J, Galvao-Sobrinho C, Thode HC, Rohatgi R Tags: Am J Nephrol Source Type: research

The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity
Conclusion: In conclusion, our results suggest that donorCYP3A5 non-expressor genotype (*3/*3) is a risk for CNI nephrotoxicity.Am J Nephrol 2018;47:182 –190 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 14, 2018 Category: Neurology Source Type: research

Renal Function Variability: An Independent Risk Factor for Graft Loss and Death following Kidney Transplantation
Conclusion: This study provides a novel analysis of the utility of eGFR variability in a large cohort. The clinical use of the slope of eGFR and eGFR variability may aid in predicting long-term graft outcomes and facilitate early patient discussions to change the trajectory of allograft function.Am J Nephrol 2018;47:191 –199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 14, 2018 Category: Neurology Source Type: research

The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity.
CONCLUSION: In conclusion, our results suggest that donor CYP3A5 non-expressor genotype (*3/*3) is a risk for CNI nephrotoxicity. PMID: 29539600 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 14, 2018 Category: Urology & Nephrology Authors: Udomkarnjananun S, Townamchai N, Chariyavilaskul P, Iampenkhae K, Pongpirul K, Sirichindakul B, Panumatrassamee K, Vanichanan J, Avihingsanon Y, Eiam-Ong S, Praditpornsilpa K Tags: Am J Nephrol Source Type: research

Renal Function Variability: An Independent Risk Factor for Graft Loss and Death following Kidney Transplantation.
Abstract BACKGROUND: Several studies have been performed to evaluate surrogate markers of long-term allograft function in renal transplant recipients. These include serum creatinine, estimated glomerular filtration rate (eGFR), slope of eGFR, and more recently eGFR variability. The aim of this study was to measure eGFR slope while assessing the variability of this slope and if high variability occurring at any time post-transplant was predictive of poorer long-term outcomes in a large cohort of kidney transplant recipients. METHODS: Adult solitary kidney transplant recipients transplanted between July 1, 2005...
Source: American Journal of Nephrology - March 14, 2018 Category: Urology & Nephrology Authors: Pilch NA, Rohan V, Rao V, Mauldin PD, Su Z, Dubay DA, Morinelli TA, Taber DJ Tags: Am J Nephrol Source Type: research

Does Dysbiosis in Intestinal Microbiome Plays a Role in Children with Relapsing Idiopathic Nephrotic Syndrome?
Am J Nephrol 2018;47:162 –163 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Neurology Source Type: research

Gut Microbiota Dysbiosis in Children with Relapsing Idiopathic Nephrotic Syndrome
Conclusion: Pediatric relapsing INS patients show gut microbiota dysbiosis, characterized by a decreased proportion of butyric acid-producing bacteria and lower fecal butyric acid quantities, concomitant with reduced circulatory Tregs.Am J Nephrol 2018;47:164 –170 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Neurology Source Type: research

Addressing Racial Disparity in the Progression of Chronic Kidney Disease: Prescribe More Fruits and Vegetables?
Am J Nephrol 2018;47:171 –173 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Neurology Source Type: research

Does Dysbiosis in Intestinal Microbiome Plays a Role in Children with Relapsing Idiopathic Nephrotic Syndrome?
PMID: 29533944 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Urology & Nephrology Authors: Crespo-Salgado J, Stewart T, Aviles DH Tags: Am J Nephrol Source Type: research

Gut Microbiota Dysbiosis in Children with Relapsing Idiopathic Nephrotic Syndrome.
CONCLUSION: Pediatric relapsing INS patients show gut microbiota dysbiosis, characterized by a decreased proportion of butyric acid-producing bacteria and lower fecal butyric acid quantities, concomitant with reduced circulatory Tregs. PMID: 29533950 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Urology & Nephrology Authors: Tsuji S, Suruda C, Hashiyada M, Kimata T, Yamanouchi S, Kitao T, Kino J, Akane A, Kaneko K Tags: Am J Nephrol Source Type: research

Addressing Racial Disparity in the Progression of Chronic Kidney Disease: Prescribe More Fruits and Vegetables?
PMID: 29533958 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 13, 2018 Category: Urology & Nephrology Authors: Chen W, Bushinsky DA Tags: Am J Nephrol Source Type: research

Race/Ethnicity, Dietary Acid Load, and Risk of End-Stage Renal Disease among US Adults with Chronic Kidney Disease
Conclusions: Among US adults with CKD, the association of DAL with progression to ESRD is stronger among NHBs than NHWs. DAL is worthy of further investigation for its contribution to kidney outcomes across race/ethnic groups.Am J Nephrol 2018;47:174 –181 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 9, 2018 Category: Neurology Source Type: research

Race/Ethnicity, Dietary Acid Load, and Risk of End-Stage Renal Disease among US Adults with Chronic Kidney Disease.
CONCLUSIONS: Among US adults with CKD, the association of DAL with progression to ESRD is stronger among NHBs than NHWs. DAL is worthy of further investigation for its contribution to kidney outcomes across race/ethnic groups. PMID: 29525790 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 9, 2018 Category: Urology & Nephrology Authors: Crews DC, Banerjee T, Wesson DE, Morgenstern H, Saran R, Burrows NR, Williams DE, Powe NR, Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team Tags: Am J Nephrol Source Type: research

Real-World Scenario Improvements in Serum Phosphorus Levels and Pill Burden in Peritoneal Dialysis Patients Treated with Sucroferric Oxyhydroxide
Conclusion: Among PD patients prescribed SO as part of routine care, improvements in serum phosphorus control and #x3e;50% reduction in PB pills/day were observed.Am J Nephrol 2018;47:153 –161 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2018 Category: Neurology Source Type: research

Real-World Scenario Improvements in Serum Phosphorus Levels and Pill Burden in Peritoneal Dialysis Patients Treated with Sucroferric Oxyhydroxide.
Abstract BACKGROUND: A database analysis was conducted to assess the effectiveness of sucroferric oxyhydroxide (SO) on lowering serum phosphorus and phosphate binder (PB) pill burden among adult peritoneal dialysis (PD) patients prescribed SO as part of routine care. METHODS: Adult PD patients (n = 258) prescribed SO through a renal pharmacy service were analyzed. Baseline was 3 months before SO prescription. SO-treated follow-up was for 6 months or until either a new PB was prescribed, SO was not refilled, PD modality changed, or patient was discharged. In-range serum phosphorus was defined as ≤5.5 m...
Source: American Journal of Nephrology - March 7, 2018 Category: Urology & Nephrology Authors: Kalantar-Zadeh K, Parameswaran V, Ficociello LH, Anderson L, Ofsthun NJ, Kwoh C, Mullon C, Kossmann RJ, Coyne DW Tags: Am J Nephrol Source Type: research

Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy
Conclusion: The addition of HCQ to RAASi resulted in a significant and safe reduction in proteinuria in patients with IgAN.Am J Nephrol 2018;47:145 –152 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 2, 2018 Category: Neurology Source Type: research

Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy.
CONCLUSION: The addition of HCQ to RAASi resulted in a significant and safe reduction in proteinuria in patients with IgAN. PMID: 29502121 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 2, 2018 Category: Urology & Nephrology Authors: Yang YZ, Liu LJ, Shi SF, Wang JW, Chen YQ, Lv JC, Zhang H Tags: Am J Nephrol Source Type: research

Awareness of the New Kidney Allocation System among United States Dialysis Providers with Low Waitlisting
It is unknown whether dialysis facility staff are aware of the new kidney allocation system implemented in December 2014, which changed how deceased donor kidneys are allocated and waiting time is calculated. U.S. dialysis facilities with low annual waitlisting (#x3c;15.2%) were surveyed as part of a large randomized study. Among 653 facilities, 57.9% of staff were aware of the policy change, with medical directors (84.4%) being more aware than social workers (73.3%), facility administrators (53.1%), nurse managers (46.4%), and other staff (43.8%). Targeted education among dialysis facilities with low waitlisting may help ...
Source: American Journal of Nephrology - February 22, 2018 Category: Neurology Source Type: research

Repeated Bioimpedance Measurements Predict Prognosis of Peritoneal Dialysis Patients
Conclusions: One-year chronic exposure to fluid overload is a strong independent risk factor for transfer to HD and death in prevalent PD patients. Although the fluid status of most PD patients is not easily changed over time, becoming euvolemic during the entire PD treatment period seems to be very important.Am J Nephrol 2018;47:120 –129 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 22, 2018 Category: Neurology Source Type: research

Pulmonary Arterial Hypertension and the Kidney: Getting to the Heart of the Matter
Am J Nephrol 2018;47:130 –133 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 22, 2018 Category: Neurology Source Type: research

Presence of Kidney Disease as an Outcome Predictor in Patients with Pulmonary Arterial Hypertension
Conclusion: CKD is frequent at PAH diagnosis and is independently associated with increased mortality. Right heart failure may induce renal hypoperfusion and congestion, and is associated with eGFR decrease.Am J Nephrol 2018;47:134 –143 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 22, 2018 Category: Neurology Source Type: research

Presence of Kidney Disease as an Outcome Predictor in Patients with Pulmonary Arterial Hypertension.
Abstract BACKGROUND: Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR
Source: American Journal of Nephrology - February 22, 2018 Category: Urology & Nephrology Authors: Bitker L, Sens F, Payet C, Turquier S, Duclos A, Cottin V, Juillard L Tags: Am J Nephrol Source Type: research

Repeated Bioimpedance Measurements Predict Prognosis of Peritoneal Dialysis Patients.
CONCLUSIONS: One-year chronic exposure to fluid overload is a strong independent risk factor for transfer to HD and death in prevalent PD patients. Although the fluid status of most PD patients is not easily changed over time, becoming euvolemic during the entire PD treatment period seems to be very important. PMID: 29471301 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 22, 2018 Category: Urology & Nephrology Authors: Kim JK, Song YR, Lee HS, Kim HJ, Kim SG Tags: Am J Nephrol Source Type: research

Awareness of the New Kidney Allocation System among United States Dialysis Providers with Low Waitlisting.
Abstract It is unknown whether dialysis facility staff are aware of the new kidney allocation system implemented in December 2014, which changed how deceased donor kidneys are allocated and waiting time is calculated. U.S. dialysis facilities with low annual waitlisting (
Source: American Journal of Nephrology - February 22, 2018 Category: Urology & Nephrology Authors: Patzer RE, Basu M, Smith KD, Plantinga L, Mohan S, Escoffery C, Kim JJ, Melanson T, Pastan SO Tags: Am J Nephrol Source Type: research

Pulmonary Arterial Hypertension and the Kidney: Getting to the Heart of the Matter.
PMID: 29471304 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 22, 2018 Category: Urology & Nephrology Authors: Kazory A, Ross EA Tags: Am J Nephrol Source Type: research

What We Do and Do Not Know about Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Women ’s Day
Chronic kidney disease affects approximately 10% of the world ’s adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women’s Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women’s health and specificall y their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50%...
Source: American Journal of Nephrology - February 16, 2018 Category: Neurology Source Type: research

What We Do and Do Not Know about Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Women's Day.
Abstract Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% o...
Source: American Journal of Nephrology - February 16, 2018 Category: Urology & Nephrology Authors: Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A, World Kidney Day Steering Committee Tags: Am J Nephrol Source Type: research

miR-499 Ameliorates Podocyte Injury by Targeting Calcineurin in Minimal Change Disease
Conclusions: MiR-499 ameliorated podocyte injury by targeting CnA α and CnAβ in a PAN-induced MCD mouse model. Delivery of miR-499 can be a novel strategy for MCD treatment.Am J Nephrol 2018;47:94 –102 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 16, 2018 Category: Neurology Source Type: research

miR-499 Ameliorates Podocyte Injury by Targeting Calcineurin in Minimal Change Disease.
CONCLUSIONS: MiR-499 ameliorated podocyte injury by targeting CnAα and CnAβ in a PAN-induced MCD mouse model. Delivery of miR-499 can be a novel strategy for MCD treatment. PMID: 29448244 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 15, 2018 Category: Urology & Nephrology Authors: Zhang K, Sun W, Zhang L, Xu X, Wang J, Hong Y Tags: Am J Nephrol Source Type: research

Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?
Background: Regulation of body iron occurs at cellular, tissue, and systemic levels. In healthy individuals, iron absorption and losses are minimal, creating a virtually closed system. In the setting of chronic kidney disease and hemodialysis (HD), increased iron losses, reduced iron absorption, and limited iron availability lead to iron deficiency. Intravenous (IV) iron therapy is frequently prescribed to replace lost iron, but determining an individual ’s iron balance and stores can be challenging and imprecise, contributing to uncertainty about the long-term safety of IV iron therapy.Summary: Patients on HD receiv...
Source: American Journal of Nephrology - February 13, 2018 Category: Neurology Source Type: research

Effect of the Opioid Crisis on the Donor Pool for Kidney Transplantation: An Analysis of National Kidney Deceased Donor Trends from 2010 –2016
Conclusion: The opioid crisis in the United States has substantially altered the kidney donor pool. Strategies to increase utilization of all potentially viable kidneys for transplant are needed, particularly in this era of new, highly effective, direct-acting antiviral therapy for HCV infection.Am J Nephrol 2018;47:84 –93 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 13, 2018 Category: Neurology Source Type: research

Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?
AJ, Wood JC Abstract BACKGROUND: Regulation of body iron occurs at cellular, tissue, and systemic levels. In healthy individuals, iron absorption and losses are minimal, creating a virtually closed system. In the setting of chronic kidney disease and hemodialysis (HD), increased iron losses, reduced iron absorption, and limited iron availability lead to iron deficiency. Intravenous (IV) iron therapy is frequently prescribed to replace lost iron, but determining an individual's iron balance and stores can be challenging and imprecise, contributing to uncertainty about the long-term safety of IV iron therapy. S...
Source: American Journal of Nephrology - February 13, 2018 Category: Urology & Nephrology Authors: Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC Tags: Am J Nephrol Source Type: research

Effect of the Opioid Crisis on the Donor Pool for Kidney Transplantation: An Analysis of National Kidney Deceased Donor Trends from 2010-2016.
CONCLUSION: The opioid crisis in the United States has substantially altered the kidney donor pool. Strategies to increase utilization of all potentially viable kidneys for transplant are needed, particularly in this era of new, highly effective, direct-acting antiviral therapy for HCV infection. PMID: 29439266 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 13, 2018 Category: Urology & Nephrology Authors: Chute DF, Sise ME Tags: Am J Nephrol Source Type: research

Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y < sub > 12 < /sub > Inhibitors among Veterans
Conclusion: CKD is common among Veterans and its true prevalence is likely being underestimated. The prevalence of dialysis-dependent CKD is higher among Veterans than the non-Veteran US population. CV events are widely co-prevalent and these patients are commonly prescribed P2Y12i. The recent increase in ticagrelor prescriptions in this patient population and large cost differences between the 3 P2Y12i underline the need for future studies to identify the preferred P2Y12i for these patients.Am J Nephrol 2018;47:67 –71 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2018 Category: Neurology Source Type: research

Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y12 Inhibitors among Veterans.
CONCLUSION: CKD is common among Veterans and its true prevalence is likely being underestimated. The prevalence of dialysis-dependent CKD is higher among Veterans than the non-Veteran US population. CV events are widely co-prevalent and these patients are commonly prescribed P2Y12i. The recent increase in ticagrelor prescriptions in this patient population and large cost differences between the 3 P2Y12i underline the need for future studies to identify the preferred P2Y12i for these patients. PMID: 29393120 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 1, 2018 Category: Urology & Nephrology Authors: Singh M, Raghavan D, Williams JS, Martin BC, Hudson TJ, Owen RR, Jain N Tags: Am J Nephrol Source Type: research

Body Mass Index Change and Hospitalization Risk in Elderly Hemodialysis Patients: Results from Japanese Dialysis Outcomes and Practice Patterns Study
Conclusions: Decreases in BMI over a relatively short-term period were independently associated with higher risk of subsequent hospitalization, particularly cardiovascular-related hospitalization, among elderly HD patients.Am J Nephrol 2018;47:48 –56 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 24, 2018 Category: Neurology Source Type: research

Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices
Conclusions: In community-dwelling older adults, higher sodium:potassium, but not sodium or potassium intake alone, was associated with decline in cognitive function, with no associations observed with micro- and macro-structural brain MRI indices. These findings do not support reduction dietary sodium/increased potassium intake to prevent cognitive decline with aging.Am J Nephrol 2018;47:57 –65 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 24, 2018 Category: Neurology Source Type: research

Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices.
CONCLUSIONS: In community-dwelling older adults, higher sodium:potassium, but not sodium or potassium intake alone, was associated with decline in cognitive function, with no associations observed with micro- and macro-structural brain MRI indices. These findings do not support reduction dietary sodium/increased potassium intake to prevent cognitive decline with aging. PMID: 29393090 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 24, 2018 Category: Urology & Nephrology Authors: Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M Tags: Am J Nephrol Source Type: research

Body Mass Index Change and Hospitalization Risk in Elderly Hemodialysis Patients: Results from Japanese Dialysis Outcomes and Practice Patterns Study.
Abstract BACKGROUND: Short-term weight gains and losses are associated with a lower and higher mortality risk, respectively, in patients undergoing hemodialysis (HD). However, little is known about their association with the risk of subsequent hospitalization. METHODS: In a prospective cohort of 1,804 HD patients aged ≥65 years enrolled in the Japanese Dialysis Outcomes and Practice Patterns Study phases 3 (2005-2008) and 4 (2009-2011), we examined the associations between changes in body mass index (BMI) over a 4-month baseline period (
Source: American Journal of Nephrology - January 24, 2018 Category: Urology & Nephrology Authors: Sumida K, Yamamoto S, Akizawa T, Fukuhara S, Fukuma S Tags: Am J Nephrol Source Type: research