Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review.
Abstract BACKGROUND: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers. SUMMARY: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-ind...
Source: American Journal of Nephrology - January 12, 2017 Category: Urology & Nephrology Authors: Wanchoo R, Karam S, Uppal NN, Barta VS, Deray G, Devoe C, Launay-Vacher V, Jhaveri KD, Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors Tags: Am J Nephrol Source Type: research

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Background: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor rather than targeting the cancer directly. These therapies have demonstrated a significant benefit in the treatment of melanomas and other cancers.Summary: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-induced kidney toxicity. In...
Source: American Journal of Nephrology - January 11, 2017 Category: Neurology Source Type: research

Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents.
Abstract BACKGROUND: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. METHODS: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary...
Source: American Journal of Nephrology - January 6, 2017 Category: Urology & Nephrology Authors: Avasare RS, Rosenstiel PE, Zaky ZS, Tsapepas DS, Appel GB, Markowitz GS, Bomback AS, Canetta PA Tags: Am J Nephrol Source Type: research

Predicting Post-Transplant Recurrence of IgA Nephropathy: The Importance of Crescents
Background: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression.Methods: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to rec...
Source: American Journal of Nephrology - January 5, 2017 Category: Neurology Source Type: research

Is Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
PMID: 28006763 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 23, 2016 Category: Urology & Nephrology Authors: Filler G, McIntyre C Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 Predicts All-Cause Mortality in a Dose-Response Fashion in Pre-Dialysis Patients with Chronic Kidney Disease.
This study aimed to summarize and quantify the predictive effects of FGF23 among the pre-dialysis CKD stages 1-5 population. METHODS: Data sources included PubMed, EMBASE, and Web of Science. Prospective cohort studies assessing the associations between FGF23 and all-cause mortality, CVD, and renal events in CKD patients were selected. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using the random-effects model. The composite higher or the highest level in FGF23 categories of each study was considered the high level. The reference level was regarded as the low level in the overall analys...
Source: American Journal of Nephrology - December 23, 2016 Category: Urology & Nephrology Authors: Xue C, Yang B, Zhou C, Dai B, Liu Y, Mao Z, Yu S, Mei C Tags: Am J Nephrol Source Type: research

Fibroblast Growth Factor 23 Predicts All-Cause Mortality in a Dose-Response Fashion in Pre-Dialysis Patients with Chronic Kidney Disease
This study aimed to summarize and quantify the predictive effects of FGF23 among the pre-dialysis CKD stages 1-5 population.Methods: Data sources included PubMed, EMBASE, and Web of Science. Prospective cohort studies assessing the associations between FGF23 and all-cause mortality, CVD, and renal events in CKD patients were selected. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using the random-effects model. The composite higher or the highest level in FGF23 categories of each study was considered the high level. The reference level was regarded as the low level in the overall analysis. Th...
Source: American Journal of Nephrology - December 22, 2016 Category: Neurology Source Type: research

Is Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
Am J Nephrol 2017;45:146-148 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 22, 2016 Category: Neurology Source Type: research

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study
Background: The role of high density lipoprotein-raising interventions in addition to statin therapy in patients with diabetes remains controversial. Chronic kidney disease (CKD) is a strong modifier of cardiovascular (CV) outcomes. We therefore investigated the impact of CKD status at baseline on outcomes in patients with diabetes randomized to standard statin or statin plus fenofibrate treatment in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial.Methods: Among 5,464 participants in the ACCORD lipid trial, 3,554 (65%) were free of CKD at baseline, while 1,910 (35%) had mild to moderate CKD. Diff...
Source: American Journal of Nephrology - December 19, 2016 Category: Neurology Source Type: research

Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study.
Abstract BACKGROUND: The role of high density lipoprotein-raising interventions in addition to statin therapy in patients with diabetes remains controversial. Chronic kidney disease (CKD) is a strong modifier of cardiovascular (CV) outcomes. We therefore investigated the impact of CKD status at baseline on outcomes in patients with diabetes randomized to standard statin or statin plus fenofibrate treatment in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial. METHODS: Among 5,464 participants in the ACCORD lipid trial, 3,554 (65%) were free of CKD at baseline, while 1,910 (35%) had mi...
Source: American Journal of Nephrology - December 17, 2016 Category: Urology & Nephrology Authors: Papademetriou V, Lovato L, Tsioufis C, Cushman W, Applegate WB, Mottle A, Punthakee Z, Nylen E, Doumas M, ACCORD Study Group Tags: Am J Nephrol Source Type: research

Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
Conclusion: Daprodustat 4-10 mg once-daily produced dose-dependent increase in hemoglobin relative to placebo in Japanese HD subjects. The doses evaluated in the study have moderately increased endogenous EPO without changes in circulating VEGF levels.Am J Nephrol 2017;45:127-135 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 16, 2016 Category: Neurology Source Type: research

Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects.
CONCLUSION: Daprodustat 4-10 mg once-daily produced dose-dependent increase in hemoglobin relative to placebo in Japanese HD subjects. The doses evaluated in the study have moderately increased endogenous EPO without changes in circulating VEGF levels. PMID: 27978511 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 16, 2016 Category: Urology & Nephrology Authors: Akizawa T, Tsubakihara Y, Nangaku M, Endo Y, Nakajima H, Kohno T, Imai Y, Kawase N, Hara K, Lepore J, Cobitz A Tags: Am J Nephrol Source Type: research

Does Serum HCO3 Predict Risk for Cardiovascular Disease
Am J Nephrol 2017;45:115-117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 12, 2016 Category: Neurology Source Type: research

Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis
Conclusion: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure.Am J Nephrol 2017;45:118-126 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Does Serum HCO < sub > 3 < /sub > Predict Risk for Cardiovascular Disease?
Am J Nephrol 2017;45:115-117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients
Background: We evaluated the prevalence, determinants and prognosis value of pulmonary hypertension (PH) in non-dialysis chronic kidney disease (CKD) patients.Methods: This is a prospective study with stages 3-5 non-dialysis-dependent CKD patients. PH was estimated by Doppler echocardiography and defined as a pulmonary artery systolic pressure above 35 mm Hg.Results: Three hundred fifty-three patients were recruited, of whom 94 (26.6%) had PH. Prevalence of PH increased with the decline of renal function: 21.6, 24.1, and 31.7% in stages 3, 4, and 5, respectively. Independent predictors of PH were age, estimated glomerular ...
Source: American Journal of Nephrology - December 10, 2016 Category: Neurology Source Type: research

Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis.
CONCLUSION: Among nonusers of diuretics in a large community-based study, higher serum bicarbonate concentrations are associated with subclinical CVD and new heart failure. PMID: 27941322 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Urology & Nephrology Authors: Kendrick JB, Zelnick L, Chonchol MB, Siscovick D, Hoofnagle AN, Ix JH, Sarnak M, Shlipak MG, Kestenbaum B, de Boer IH Tags: Am J Nephrol Source Type: research

Does Serum HCO3 Predict Risk for Cardiovascular Disease?
PMID: 27941338 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 10, 2016 Category: Urology & Nephrology Authors: Wesson DE Tags: Am J Nephrol Source Type: research

Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients.
cute;mez JM Abstract BACKGROUND: We evaluated the prevalence, determinants and prognosis value of pulmonary hypertension (PH) in non-dialysis chronic kidney disease (CKD) patients. METHODS: This is a prospective study with stages 3-5 non-dialysis-dependent CKD patients. PH was estimated by Doppler echocardiography and defined as a pulmonary artery systolic pressure above 35 mm Hg. RESULTS: Three hundred fifty-three patients were recruited, of whom 94 (26.6%) had PH. Prevalence of PH increased with the decline of renal function: 21.6, 24.1, and 31.7% in stages 3, 4, and 5, respectively. Independent predic...
Source: American Journal of Nephrology - December 10, 2016 Category: Urology & Nephrology Authors: Reque J, Garcia-Prieto A, Linares T, Vega A, Abad S, Panizo N, Quiroga B, Collado Boira EJ, López-Gómez JM Tags: Am J Nephrol Source Type: research

Acknowledgement to the Reviewers
Am J Nephrol 2016;44:493-495 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 7, 2016 Category: Neurology Source Type: research

Contents Vol. 44, 2016
Am J Nephrol 2016;44:I-V (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 7, 2016 Category: Neurology Source Type: research

The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation
Background: Non-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes.Methods: This was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival.Results: The number of transplants that were included in the analysis was 4,646 (3,656 with complet...
Source: American Journal of Nephrology - December 2, 2016 Category: Neurology Source Type: research

Adherence in Kidney Transplant Recipients
Am J Nephrol 2017;45:89-90 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 2, 2016 Category: Neurology Source Type: research

Simple Cysts in Donor Kidney Contribute to Reduced Allograft Function
Background: Simple renal cysts may be an early marker of renal disease. We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation.Methods: We retrospectively reviewed records of donors and recipients from 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital. Ninety-one donors with renal cysts and 64 recipients with cysts in donor kidney were noted. We compared these 64 cases to 128 no cyst-bearing controls matched for the donor gender, recipient gender, donor baseline serum creatinine (sCr), do...
Source: American Journal of Nephrology - December 2, 2016 Category: Neurology Source Type: research

Adherence in Kidney Transplant Recipients.
PMID: 27907912 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - December 2, 2016 Category: Urology & Nephrology Authors: Cukor D Tags: Am J Nephrol Source Type: research

Simple Cysts in Donor Kidney Contribute to Reduced Allograft Function.
Abstract BACKGROUND: Simple renal cysts may be an early marker of renal disease. We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation. METHODS: We retrospectively reviewed records of donors and recipients from 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital. Ninety-one donors with renal cysts and 64 recipients with cysts in donor kidney were noted. We compared these 64 cases to 128 no cyst-bearing controls matched for the donor gender, recipient gender, donor baseline se...
Source: American Journal of Nephrology - December 2, 2016 Category: Urology & Nephrology Authors: Qiu W, Jiang Y, Wu J, Huang H, Xie W, Xie X, Chen J, Peng W Tags: Am J Nephrol Source Type: research

The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation.
Abstract BACKGROUND: Non-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes. METHODS: This was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival. RESULTS: The number of transplants that were included in the analysis...
Source: American Journal of Nephrology - December 2, 2016 Category: Urology & Nephrology Authors: Taber DJ, Fleming JN, Fominaya CE, Gebregziabher M, Hunt KJ, Srinivas TR, Baliga PK, McGillicuddy JW, Egede LE Tags: Am J Nephrol Source Type: research

High Pulse-Wave Velocity Defines a Very High Cardiovascular Risk Cohort of Dialysis Patients under Age 60.
Abstract BACKGROUND: Patients with end-stage renal disease (ESRD) are at a high risk of cardiovascular mortality (CVM). In patients with ESRD, arterial stiffness increases at an earlier age when compared to the general population and this contributes to the overall risk of cardiovascular mortality. The main objective of this study was to clarify the interplay between age and cardiovascular alterations in ESRD. METHODS: Prospective, observational cohort study initiated in April 1987 until the end of 1998 with events recorded until the end of the year 2000 at the F.H. Manhes Hospital Center, Fleury-Mérog...
Source: American Journal of Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Ferreira JP, Girerd N, Pannier B, Rossignol P, London GM Tags: Am J Nephrol Source Type: research

Arterial Stiffness as a Cardiovascular Risk Factor in Stage 5D Chronic Kidney Disease Patients: An Age Affair.
PMID: 27898424 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Zoccali C, Mallamaci F Tags: Am J Nephrol Source Type: research

High Pulse-Wave Velocity Defines a Very High Cardiovascular Risk Cohort of Dialysis Patients under Age 60
Background: Patients with end-stage renal disease (ESRD) are at a high risk of cardiovascular mortality (CVM). In patients with ESRD, arterial stiffness increases at an earlier age when compared to the general population and this contributes to the overall risk of cardiovascular mortality. The main objective of this study was to clarify the interplay between age and cardiovascular alterations in ESRD.Methods: Prospective, observational cohort study initiated in April 1987 until the end of 1998 with events recorded until the end of the year 2000 at the F.H. Manhes Hospital Center, Fleury-M érogis (in the Paris/Ile de...
Source: American Journal of Nephrology - November 29, 2016 Category: Neurology Source Type: research

Arterial Stiffness as a Cardiovascular Risk Factor in Stage 5D Chronic Kidney Disease Patients: An Age Affair
Am J Nephrol 2017;45:69-71 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 29, 2016 Category: Neurology Source Type: research

Complement Activation-Related Pseudo-Allergy: A Fresh Look at Hypersensitivity Reactions to Intravenous Iron.
PMID: 27894115 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 29, 2016 Category: Urology & Nephrology Authors: Macdougall IC, Vernon K Tags: Am J Nephrol Source Type: research

Trajectories and Predictors of Allograft Dysfunction after Renal Transplantation in Children.
CONCLUSION: This study suggests that donation from living donors and from younger donors are favorable factors for long-term allograft function. PMID: 27894119 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 29, 2016 Category: Urology & Nephrology Authors: de Souza VC, Rabilloud M, Cochat P, Wagner MB, Garcia CD, Ranchin B, Iwaz J, Selistre L, Dubourg L Tags: Am J Nephrol Source Type: research

Trajectories and Predictors of Allograft Dysfunction after Renal Transplantation in Children
Conclusion: This study suggests that donation from living donors and from younger donors are favorable factors for long-term allograft function.Am J Nephrol 2017;45:63-68 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 28, 2016 Category: Neurology Source Type: research

Complement Activation-Related Pseudo-Allergy: A Fresh Look at Hypersensitivity Reactions to Intravenous Iron
Am J Nephrol 2017;45:60-62 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 28, 2016 Category: Neurology Source Type: research

Distinct in vitro Complement Activation by Various Intravenous Iron Preparations.
CONCLUSION: This study provides evidence that iron dextran and ferric carboxymaltose have complement-activating capacities in-vitro, and hypersensitivity reactions to these drugs could be CARPA-mediated. PMID: 27889746 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 26, 2016 Category: Urology & Nephrology Authors: Hempel JC, Poppelaars F, Gaya da Costa M, Franssen CF, de Vlaam TP, Daha MR, Berger SP, Seelen MA, Gaillard CA Tags: Am J Nephrol Source Type: research

Distinct in vitro Complement Activation by Various Intravenous Iron Preparations
Conclusion: This study provides evidence that iron dextran and ferric carboxymaltose have complement-activating capacities in-vitro, and hypersensitivity reactions to these drugs could be CARPA-mediated.Am J Nephrol 2017;45:49-59 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 25, 2016 Category: Neurology Source Type: research

2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial.
Abstract BACKGROUND: Vitamin D analogs and calcimimetics are used to manage secondary hyperparathyroidism (SHPT) in dialysis patients. DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients. The safety and effectiveness of DP001 suppressing PTH in dialysis patients previously managed with active vitamin D with or without a calcimimetic are presented. METHODS: A multicenter, randomized, double-blind study compared DP001 to placebo in hemodialysis patients with serum-intact PTH (iPTH) ≥300 pg/ml. The primary efficacy endpoint wa...
Source: American Journal of Nephrology - November 24, 2016 Category: Urology & Nephrology Authors: Thadhani R, Zella JB, Knutson DC, Blaser WJ, Plum LA, Clagett-Dame M, Buck RD, DeLuca HF Tags: Am J Nephrol Source Type: research

2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial
Background: Vitamin D analogs and calcimimetics are used to manage secondary hyperparathyroidism (SHPT) in dialysis patients. DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients. The safety and effectiveness of DP001 suppressing PTH in dialysis patients previously managed with active vitamin D with or without a calcimimetic are presented.Methods: A multicenter, randomized, double-blind study compared DP001 to placebo in hemodialysis patients with serum-intact PTH (iPTH) ≥300 pg/ml. The primary efficacy endpoint was the proportion of pati...
Source: American Journal of Nephrology - November 23, 2016 Category: Neurology Source Type: research

Disparities in Kidney Transplantation Access among Korean Patients Initiating Dialysis: A Population-Based Cohort Study Using National Health Insurance Data (2003-2013).
CONCLUSIONS: Our findings indicate that in South Korea, the total number of kidney transplants is remarkably low and there exists income disparity with regard to access to kidney transplantation. Thus, we suggest that plans be implemented to encourage organ donation and increase organ transplant accessibility for all patients irrespective of their socioeconomic status. PMID: 27866205 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 19, 2016 Category: Urology & Nephrology Authors: Choi Y, Shin J, Park JT, Cho KH, Park EC, Kim TH Tags: Am J Nephrol Source Type: research

Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis.
Abstract BACKGROUND: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. METHODS: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients i...
Source: American Journal of Nephrology - November 19, 2016 Category: Urology & Nephrology Authors: Lin YS, Yeh CC, Lin YC, Su CT, Sung FC, Chang SN, Liu YR, Su FH Tags: Am J Nephrol Source Type: research

Disparities in Kidney Transplantation Access among Korean Patients Initiating Dialysis: A Population-Based Cohort Study Using National Health Insurance Data (2003-2013)
Conclusions: Our findings indicate that in South Korea, the total number of kidney transplants is remarkably low and there exists income disparity with regard to access to kidney transplantation. Thus, we suggest that plans be implemented to encourage organ donation and increase organ transplant accessibility for all patients irrespective of their socioeconomic status.Am J Nephrol 2017;45:32-39 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 18, 2016 Category: Neurology Source Type: research

Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis
Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection.Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs w...
Source: American Journal of Nephrology - November 18, 2016 Category: Neurology Source Type: research

Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
CONCLUSION: Taken together, these findings suggest that CKD impacts vitamin K metabolism, and this occurs early in the disease course. Our findings that vitamin K metabolism is altered in the presence of CKD provides further support that sub-clinical vitamin K deficiency may represent a modifiable risk factor for vascular and bone health in this population. PMID: 27846632 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 16, 2016 Category: Urology & Nephrology Authors: McCabe KM, Booth SL, Fu X, Ward E, Adams MA, Holden RM Tags: Am J Nephrol Source Type: research

Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease
Conclusion: Taken together, these findings suggest that CKD impacts vitamin K metabolism, and this occurs early in the disease course. Our findings that vitamin K metabolism is altered in the presence of CKD provides further support that sub-clinical vitamin K deficiency may represent a modifiable risk factor for vascular and bone health in this population.Am J Nephrol 2017;45:4-13 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 15, 2016 Category: Neurology Source Type: research

Effect of a Dialysis Access Coordinator on Preemptive Access Placement among Veterans: A Quality Improvement Initiative.
CONCLUSIONS: Implementation of an access coordinator was associated with a modest increase in preemptive access placement among patients who are at high risk for ESRD without increasing the prevalence of unused access. PMID: 27842302 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 15, 2016 Category: Urology & Nephrology Authors: Gale RC, Kehoe D, Lit YZ, Asch SM, Kurella Tamura M Tags: Am J Nephrol Source Type: research

Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up.
PMID: 27842304 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 15, 2016 Category: Urology & Nephrology Authors: Fusaro M, Plebani M, Iervasi G, Gallieni M Tags: Am J Nephrol Source Type: research

Effect of a Dialysis Access Coordinator on Preemptive Access Placement among Veterans: A Quality Improvement Initiative
Conclusions: Implementation of an access coordinator was associated with a modest increase in preemptive access placement among patients who are at high risk for ESRD without increasing the prevalence of unused access.Am J Nephrol 2017;45:14-21 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 14, 2016 Category: Neurology Source Type: research

Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up
Am J Nephrol 2017;45:1-3 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 14, 2016 Category: Neurology Source Type: research

Urinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy
Background: Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN).Methods: Of 399 patients from a glomerulonephritis cohort recruited between January 2009 and December 2014, 314 were enrolled. Serum and urine periostin (uPOSTN) were measured using enzyme-linked immunosorbent assay. We divided the patients into 3 groups by uPOSTN/cre...
Source: American Journal of Nephrology - November 1, 2016 Category: Neurology Source Type: research