Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study
Background: Stroke prevention in dialysis-dependent patients with atrial fibrillation (AF) is an unresolved clinical dilemma. Indeed, no randomized controlled trial evaluating the efficacy and safety of oral anticoagulants in this population, has been conducted so far. Observational research on the use of warfarin in patients on dialysis has shown conflicting results. This uncertainty is mirrored by the wide variations in warfarin prescription patterns across centers. We sought to evaluate the association between the use of vitamin K antagonists (VKAs) and mortality among hemodialysis patient with AF and to assess potentia...
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Oral Anticoagulation in End-Stage Renal Disease: Is It Time to Absolve Warfarin?
Am J Nephrol 2016;44:255-257 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Patients' Characteristics Affect the Survival Benefit of Warfarin Treatment for Hemodialysis Patients with Atrial Fibrillation. A Historical Cohort Study.
Abstract BACKGROUND: Stroke prevention in dialysis-dependent patients with atrial fibrillation (AF) is an unresolved clinical dilemma. Indeed, no randomized controlled trial evaluating the efficacy and safety of oral anticoagulants in this population, has been conducted so far. Observational research on the use of warfarin in patients on dialysis has shown conflicting results. This uncertainty is mirrored by the wide variations in warfarin prescription patterns across centers. We sought to evaluate the association between the use of vitamin K antagonists (VKAs) and mortality among hemodialysis patient with AF and ...
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Brancaccio D, Neri L, Bellocchio F, Barbieri C, Amato C, Mari F, Canaud B, Stuard S Tags: Am J Nephrol Source Type: research

Oral Anticoagulation in End-Stage Renal Disease: Is It Time to Absolve Warfarin?
PMID: 27598337 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Genovesi S Tags: Am J Nephrol Source Type: research

Parathyroidectomy Increases Heart Rate Variability and Leptin Levels in Patients with Stage 5 Chronic Kidney Disease.
CONCLUSION: Circulating leptin levels may be a novel treatment target to reduce CVD risk in advanced CKD-MBD patients. PMID: 27598394 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Urology & Nephrology Authors: Jiang Y, Shen Z, Zhang J, Xing C, Zha X, Shen C, Zeng M, Yang G, Mao H, Zhang B, Yu X, Sun B, Ouyang C, Ge Y, Zhang L, Cheng C, Zhang J, Yin C, Chen H, Wang N Tags: Am J Nephrol Source Type: research

Erratum
Am J Nephrol 2016;44:170 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 6, 2016 Category: Neurology Source Type: research

Serum Potassium Levels and Mortality in Hemodialysis Patients: A Retrospective Cohort Study.
This study used annual cohorts of hemodialysis patients during 2007-2010. To determine hyperkalemia prevalence, monthly hyperkalemia was defined as serum potassium level ≥5.5 mEq/l; prevalence was calculated as a ratio of hyperkalemia episodes to follow-up time, reported separately by long and short interdialytic interval. To determine the impact of hyperkalemia on mortality, patients in the 2010 cohort were followed from first potassium measurement until death or a censoring event; hyperkalemia was defined, sequentially, by potassium levels 5.5-6.0 mEq/l at 0.1 mEq/l intervals. Time-dependent Cox proportional hazards m...
Source: American Journal of Nephrology - September 2, 2016 Category: Urology & Nephrology Authors: Yusuf AA, Hu Y, Singh B, Menoyo JA, Wetmore JB Tags: Am J Nephrol Source Type: research

Prognostic Utility of a Self-Reported Depression Questionnaire versus Clinician-Based Assessment on Renal Outcomes.
CONCLUSIONS: QIDS-SR16 cutoff ≥8 adds to the prognostic information available to practicing nephrologists during routine clinic visits from comorbidities and laboratory data. This cutoff score performs similar to a clinician diagnosis of MDD and provides a feasible and time-saving alternative to an interview-based MDD diagnosis for determining prognosis in CKD patients. PMID: 27592294 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 2, 2016 Category: Urology & Nephrology Authors: Jain N, Carmody T, Minhajuddin AT, Toups M, Trivedi MH, Rush AJ, Hedayati SS Tags: Am J Nephrol Source Type: research

Prognostic Utility of a Self-Reported Depression Questionnaire versus Clinician-Based Assessment on Renal Outcomes
Conclusions: QIDS-SR16 cutoff ≥8 adds to the prognostic information available to practicing nephrologists during routine clinic visits from comorbidities and laboratory data. This cutoff score performs similar to a clinician diagnosis of MDD and provides a feasible and time-saving alternative to an interview-based MDD diagnosi s for determining prognosis in CKD patients.Am J Nephrol 2016;44:234-244 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 2, 2016 Category: Neurology Source Type: research

Serum Potassium Levels and Mortality in Hemodialysis Patients: A Retrospective Cohort Study
This study used annual cohorts of hemodialysis patients during 2007-2010. To determine hyperkalemia prevalence, monthly hyperkalemia was defined as serum potassium level ≥5.5 mEq/l; prevalence was calculated as a ratio of hyperkalemia episodes to follow-up time, reported separately by long and short interdialytic interval. To determine the impact of hyperkalemia on mortality, patients in the 2010 cohort were followed from first potassium measurement until death or a censoring event; hyperkalemia was defined, sequentially, by potassium levels 5.5-6.0 mEq/l at 0.1 mEq/l intervals. Time-dependent Cox proportional hazards m...
Source: American Journal of Nephrology - September 2, 2016 Category: Neurology Source Type: research

Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients
Background: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy andHelicobacter pylori status.Methods: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by gastroduodenoscopy and fo...
Source: American Journal of Nephrology - August 30, 2016 Category: Neurology Source Type: research

New Onset Hypertension Linked to Generic Cyclosporine Substitution in Post-Renal Transplant Patient
This is case report and review of the literature focused on generic substitutions of cyclosporine and its consequences. The pharmacokinetics and pharmacodynamics of the generic substitutions are clear different than the parent compound Sandimmune and can lead to different outcomes, as was the case in this report. A detailed accounting of the patients history led to the discovery of the problem and sorting back to a the branded drug supported the hypothesis.Am J Nephrol 2016;44:219-223 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Neurology Source Type: research

Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis
Conclusions: Not all generic immunosuppressive drugs have similar relative bioavailability to their brand name counterparts. Evidence on their efficacy and safety is inconclusive. Tighter regulatory requirement for approval of generic drugs with narrow therapeutic index is needed.Am J Nephrol 2016;44:206-218 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Neurology Source Type: research

The Tyranny of Generic Immunosuppressants
Am J Nephrol 2016;44:204-205 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Neurology Source Type: research

Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease
Conclusions: Titration of a V2RA aimed to maintain aquaresis at a high level showed a better renoprotective effect compared to FD administration. However, this treatment regimen was poorly tolerated and did not overcome treatment unresponsiveness when started later in the disease.Am J Nephrol 2016;44:194-203 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Neurology Source Type: research

Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Not all generic immunosuppressive drugs have similar relative bioavailability to their brand name counterparts. Evidence on their efficacy and safety is inconclusive. Tighter regulatory requirement for approval of generic drugs with narrow therapeutic index is needed. PMID: 27576318 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Tsipotis E, Gupta NR, Raman G, Zintzaras E, Jaber BL Tags: Am J Nephrol Source Type: research

New Onset Hypertension Linked to Generic Cyclosporine Substitution in Post-Renal Transplant Patient.
Abstract This is case report and review of the literature focused on generic substitutions of cyclosporine and its consequences. The pharmacokinetics and pharmacodynamics of the generic substitutions are clear different than the parent compound Sandimmune and can lead to different outcomes, as was the case in this report. A detailed accounting of the patients history led to the discovery of the problem and sorting back to a the branded drug supported the hypothesis. PMID: 27576478 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Al Dhaybi O, Bakris G Tags: Am J Nephrol Source Type: research

The Tyranny of Generic Immunosuppressants.
PMID: 27576500 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Ravichandran B, Weir MR Tags: Am J Nephrol Source Type: research

Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease.
CONCLUSIONS: Titration of a V2RA aimed to maintain aquaresis at a high level showed a better renoprotective effect compared to FD administration. However, this treatment regimen was poorly tolerated and did not overcome treatment unresponsiveness when started later in the disease. PMID: 27578560 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Zittema D, Versteeg IB, Gansevoort RT, van Goor H, de Heer E, Veraar KA, Peters DJ, Meijer E Tags: Am J Nephrol Source Type: research

Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients.
Abstract BACKGROUND: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy and Helicobacter pylori status. METHODS: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by ...
Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Sakao Y, Sugimoto M, Ichikawa H, Sahara S, Tsuji T, Ohashi N, Kato A, Fujigaki Y, Sugimoto K, Furuta T, Sakao T, Yasuda H Tags: Am J Nephrol Source Type: research

A Systematic Review and Meta-Analysis of Kidney and Pregnancy Outcomes in IgA Nephropathy.
CONCLUSIONS: Pregnancy in IgAN patients with preserved kidney function did not accelerate deterioration of renal function. But pregnant women with IgAN are at higher risk of pregnancy complications. PMID: 27578454 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2016 Category: Urology & Nephrology Authors: Liu Y, Ma X, Zheng J, Liu X, Yan T Tags: Am J Nephrol Source Type: research

A Systematic Review and Meta-Analysis of Kidney and Pregnancy Outcomes in IgA Nephropathy
Conclusions: Pregnancy in IgAN patients with preserved kidney function did not accelerate deterioration of renal function. But pregnant women with IgAN are at higher risk of pregnancy complications.Am J Nephrol 2016;44:187-193 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2016 Category: Neurology Source Type: research

Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease.
Abstract BACKGROUND: Long-term clinical outcomes in children with very-early onset (VEO; diagnosis in utero or within the first 18 months of life) autosomal dominant polycystic kidney disease (ADPKD) are currently not well understood. We conducted a longitudinal retrospective cohort study to assess the association between VEO status and adverse clinical outcomes. METHODS: Seventy patients with VEO-ADPKD matched (by year of birth, sex and race/ethnicity) to 70 patients with non-VEO-ADPKD who participated in research at the University of Colorado were studied. Kaplan-Meier survival analysis was performed. The p...
Source: American Journal of Nephrology - August 22, 2016 Category: Urology & Nephrology Authors: Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer B Tags: Am J Nephrol Source Type: research

Rivaroxaban in Chronic Hemodialysis Patients: Clarification of an Editorial Error.
PMID: 27548702 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 22, 2016 Category: Urology & Nephrology Authors: Dias C, Moore KT, Murphy J, Ariyawansa J, Smith W, Mills RM, Weir MR Tags: Am J Nephrol Source Type: research

Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease
Background: Long-term clinical outcomes in children with very-early onset (VEO; diagnosis in utero or within the first 18 months of life) autosomal dominant polycystic kidney disease (ADPKD) are currently not well understood. We conducted a longitudinal retrospective cohort study to assess the association between VEO status and adverse clinical outcomes.Methods: Seventy patients with VEO-ADPKD matched (by year of birth, sex and race/ethnicity) to 70 patients with non-VEO-ADPKD who participated in research at the University of Colorado were studied. Kaplan-Meier survival analysis was performed. The predictor was VEO status,...
Source: American Journal of Nephrology - August 22, 2016 Category: Neurology Source Type: research

Rivaroxaban in Chronic Hemodialysis Patients: Clarification of an Editorial Error
Am J Nephrol 2016;44:169 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 22, 2016 Category: Neurology Source Type: research

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome.
This study was designed to analyze the characteristics of the genotype and phenotype, and follow-up in the largest group of Chinese patients with GS. METHODS: Sixty-seven patients with GS underwent SLCl2A3 analysis, and their clinical characteristics and biochemical findings as well as follow-up were reviewed, aiming to achieve a better description of GS. Additionally, the association of genotype and phenotype was explored. RESULTS: Forty-one different mutations were identified within these 67 GS patients, including 11 novel mutations and 5 recurrent ones. Typical hypocalciuria and hypomagnesemia were not found i...
Source: American Journal of Nephrology - August 16, 2016 Category: Urology & Nephrology Authors: Liu T, Wang C, Lu J, Zhao X, Lang Y, Shao L Tags: Am J Nephrol Source Type: research

A Double-Blind, Placebo Controlled, Randomized Phase 1 Cross-Over Study with ALLN-177, an Orally Administered Oxalate Degrading Enzyme.
CONCLUSIONS: In healthy volunteers, with diet-induced hyperoxaluria treatment with ALLN-177, when compared to placebo, significantly reduced urinary oxalate excretion by degrading dietary oxalate in the gastrointestinal tract and thereby reducing its absorption. ALLN-177 may represent a new approach for managing secondary hyperoxaluria and its complications. PMID: 27529510 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 16, 2016 Category: Urology & Nephrology Authors: Langman CB, Grujic D, Pease RM, Easter L, Nezzer J, Margolin A, Brettman L Tags: Am J Nephrol Source Type: research

Plasma Exchange as an Adjunctive Therapy for Crescentic IgA Nephropathy.
Abstract BACKGROUND: Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined. METHODS: Twelve patients with severe CreIgAN who received PE as addition to routine immunosuppressive therapy, followed for more than 6 months, were involved. Twelve matched historical controls who received immunosuppressive therapy alone were selected by propensity score matching. Renal survival, plasma IgA-IgG complex and active complement products were assessed. RESULTS: Nine men and 3 women received a median o...
Source: American Journal of Nephrology - August 16, 2016 Category: Urology & Nephrology Authors: Xie X, Lv J, Shi S, Zhu L, Liu L, Chen M, Wang Y, Cui Z, Wang X, Liu L, Yu X, Zhou F, Zhao MH, Zhang H Tags: Am J Nephrol Source Type: research

Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome
This study was designed to analyze the characteristics of the genotype and phenotype, and follow-up in the largest group of Chinese patients with GS.Methods: Sixty-seven patients with GS underwentSLCl2A3 analysis, and their clinical characteristics and biochemical findings as well as follow-up were reviewed, aiming to achieve a better description of GS. Additionally, the association of genotype and phenotype was explored.Results: Forty-one different mutations were identified within these 67 GS patients, including 11 novel mutations and 5 recurrent ones. Typical hypocalciuria and hypomagnesemia were not found in 6 (9%) and ...
Source: American Journal of Nephrology - August 16, 2016 Category: Neurology Source Type: research

A Double-Blind, Placebo Controlled, Randomized Phase 1 Cross-Over Study with ALLN-177, an Orally Administered Oxalate Degrading Enzyme
Conclusions: In healthy volunteers, with diet-induced hyperoxaluria treatment with ALLN-177, when compared to placebo, significantly reduced urinary oxalate excretion by degrading dietary oxalate in the gastrointestinal tract and thereby reducing its absorption. ALLN-177 may represent a new approach for managing secondary hyperoxaluria and its complications.Am J Nephrol 2016;44:150-158 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 16, 2016 Category: Neurology Source Type: research

Plasma Exchange as an Adjunctive Therapy for Crescentic IgA Nephropathy
Background: Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined.Methods: Twelve patients with severe CreIgAN who received PE as addition to routine immunosuppressive therapy, followed for more than 6 months, were involved. Twelve matched historical controls who received immunosuppressive therapy alone were selected by propensity score matching. Renal survival, plasma IgA-IgG complex and active complement products were assessed.Results: Nine men and 3 women received a median of 7 PE courses (range 5-10). T...
Source: American Journal of Nephrology - August 16, 2016 Category: Neurology Source Type: research

Chronic Kidney Disease Classification in Systolic Blood Pressure Intervention Trial: Comparison Using Modification of Diet in Renal Disease and CKD-Epidemiology Collaboration Definitions.
We examined the classification of CKD at baseline using both equations in the Systolic Blood Pressure Intervention Trial (SPRINT). eGFR was calculated at baseline using fasting serum creatinine values from a central laboratory. RESULTS: Among 9,308 participants with baseline CKD classification using the 4-variable MDRD equation specified in the SPRINT protocol, 681 (7.3%) participants were reclassified to a less advanced CKD stage (higher eGFR) and 346 (3.7%) were reclassified to a more advanced CKD stage (lower eGFR) when the CKD-EPI equation was used to calculate eGFR. For eGFRs
Source: American Journal of Nephrology - August 11, 2016 Category: Urology & Nephrology Authors: Rocco MV, Chapman A, Chertow GM, Cohen D, Chen J, Cutler JA, Diamond MJ, Freedman BI, Hawfield A, Judd E, Killeen AA, Kirchner K, Lewis CE, Pajewski NM, Wall BM, Yee J, SPRINT Research Group Tags: Am J Nephrol Source Type: research

Chronic Kidney Disease Classification in Systolic Blood Pressure Intervention Trial: Comparison Using Modification of Diet in Renal Disease and CKD-Epidemiology Collaboration Definitions
We examined the classification of CKD at baseline using both equations in the Systolic Blood Pressure Intervention Trial (SPRINT). eGFR was calculated at baseline using fasting serum creatinine values from a central laboratory.Results: Among 9,308 participants with baseline CKD classification using the 4-variable MDRD equation specified in the SPRINT protocol, 681 (7.3%) participants were reclassified to a less advanced CKD stage (higher eGFR) and 346 (3.7%) were reclassified to a more advanced CKD stage (lower eGFR) when the CKD-EPI equation was used to calculate eGFR. For eGFRs (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 11, 2016 Category: Neurology Source Type: research

Medication Intervention for Chronic Kidney Disease Patients Transitioning from Hospital to Home: Study Design and Baseline Characteristics.
CONCLUSION: Participants in CKD-MIT are typical of acutely ill hospitalized patients with CKD. A medication management intervention after hospital discharge is under study to reduce post-hospitalization acute care utilization and to improve CKD management. PMID: 27487357 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 3, 2016 Category: Urology & Nephrology Authors: Alicic RZ, Short RA, Corbett CL, Neumiller JJ, Gates BJ, Daratha KB, Barbosa-Leiker C, McPherson S, Chaytor NS, Dieter BP, Setter SM, Tuttle KR Tags: Am J Nephrol Source Type: research

Medication Intervention for Chronic Kidney Disease Patients Transitioning from Hospital to Home: Study Design and Baseline Characteristics
Conclusion: Participants in CKD-MIT are typical of acutely ill hospitalized patients with CKD. A medication management intervention after hospital discharge is under study to reduce post-hospitalization acute care utilization and to improve CKD management.Am J Nephrol 2016;44:122-129 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 3, 2016 Category: Neurology Source Type: research

Erratum.
Authors: PMID: 27454610 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 29, 2016 Category: Urology & Nephrology Tags: Am J Nephrol Source Type: research

Genetic Features of Chinese Patients with Gitelman Syndrome: Sixteen Novel SLC12A3 Mutations Identified in a New Cohort
Conclusion: Sixteen novel SLC12A3 pathogenic mutations were identified in a cohort of Chinese patients with GS. T60M and D486N were most frequent and appear to be important candidate alleles in Chinese patients with GS. Am J Nephrol 2016;44:113-121 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 26, 2016 Category: Neurology Source Type: research

Genetic Features of Chinese Patients with Gitelman Syndrome: Sixteen Novel SLC12A3 Mutations Identified in a New Cohort.
CONCLUSION: Sixteen novel SLC12A3 pathogenic mutations were identified in a cohort of Chinese patients with GS. T60M and D486N were most frequent and appear to be important candidate alleles in Chinese patients with GS. PMID: 27454426 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 25, 2016 Category: Urology & Nephrology Authors: Ma J, Ren H, Lin L, Zhang C, Wang Z, Xie J, Shen PY, Zhang W, Wang W, Chen XN, Chen N Tags: Am J Nephrol Source Type: research

Erratum
Am J Nephrol 2016;44:84 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 25, 2016 Category: Neurology Source Type: research

Genetic Features of Chinese Patients with Gitelman Syndrome: Sixteen Novel < b > < i > SLC12A3 < /i > < /b > Mutations Identified in a New Cohort
Conclusion: Sixteen novel SLC12A3 pathogenic mutations were identified in a cohort of Chinese patients with GS. T60M and D486N were most frequent and appear to be important candidate alleles in Chinese patients with GS. Am J Nephrol 2016;44:113-121 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 25, 2016 Category: Neurology Source Type: research

Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients.
CONCLUSIONS: In contrast with SEV, SFOH did not appear to impact the iPTH-lowering effect of oral VDRAs. PMID: 27434393 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 19, 2016 Category: Urology & Nephrology Authors: Sprague SM, Covic AC, Floege J, Ketteler M, Botha J, Chong EM, Rastogi A Tags: Am J Nephrol Source Type: research

Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients
Conclusions: In contrast with SEV, SFOH did not appear to impact the iPTH-lowering effect of oral VDRAs.Am J Nephrol 2016;44:104-112 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 19, 2016 Category: Neurology Source Type: research

Racial Disparities in End-of-Life Issues in Patients with Chronic Kidney Disease.
PMID: 27410237 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2016 Category: Urology & Nephrology Authors: Norris KC, Nicholas SB Tags: Am J Nephrol Source Type: research

Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria.
CONCLUSIONS: KTA in patients with CKD secondary to EH should not be recommended due to high risk of recurrence. Although other centers showed good long-term outcomes in CIKTx, our patient experienced recurrence of EH due to oxalate transporter defect, early kidney allograft dysfunction and prolonged antibiotic use. PMID: 27410399 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2016 Category: Urology & Nephrology Authors: Ekser B, Mangus RS, Kubal CA, Fridell JA, Powelson JA, Nagaraju S, Mihaylov P, Phillips CL, Saxena R, Goggins WC Tags: Am J Nephrol Source Type: research

Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer.
Abstract The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonance and mass spectroscopy, has allowed large-scale analysis of small molecules to be interrogated in a targeted or untargeted manner. Recent advances from both human and animal studies that have arisen from metabolomic analysis have recognized that mitochondrial function and fatty acid oxidatio...
Source: American Journal of Nephrology - July 13, 2016 Category: Urology & Nephrology Authors: Darshi M, Van Espen B, Sharma K Tags: Am J Nephrol Source Type: research

Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer
The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonance and mass spectroscopy, has allowed large-scale analysis of small molecules to be interrogated in a targeted or untargeted manner. Recent advances from both human and animal studies that have arisen from metabolomic analysis have recognized that mitochondrial function and fatty acid oxidation play key roles i...
Source: American Journal of Nephrology - July 13, 2016 Category: Neurology Source Type: research

Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria
Conclusions: KTA in patients with CKD secondary to EH should not be recommended due to high risk of recurrence. Although other centers showed good long-term outcomes in CIKTx, our patient experienced recurrence of EH due to oxalate transporter defect, early kidney allograft dysfunction and prolonged antibiotic use.Am J Nephrol 2016;44:85-91 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2016 Category: Neurology Source Type: research

Racial Disparities in End-of-Life Issues in Patients with Chronic Kidney Disease
Am J Nephrol 2016;44:81-83 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 13, 2016 Category: Neurology Source Type: research

Recurrent Vascular Access Dysfunction as a Novel Marker of Cardiovascular Outcome and Mortality in Hemodialysis Patients.
CONCLUSIONS: Recurrent VA dysfunction was a novel independent risk factor for CV and composite ACM/CV events in HD patients, but not for VA abandonment. Patients with recurrent vascular dysfunction should be carefully monitored not only for VA patency but also for CV events. PMID: 27398601 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 11, 2016 Category: Urology & Nephrology Authors: Kim HJ, Lee H, Kim DK, Oh KH, Kim YS, Ahn C, Han JS, Min SK, Min SI, Kim HC, Joo KW Tags: Am J Nephrol Source Type: research