Hemodialysis Patients with Hepatitis C Infection Are Not Receiving the New Antiviral Medications.
PMID: 26044708 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 3, 2015 Category: Urology & Nephrology Authors: Goodkin DA, Bieber B Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab.
CONCLUSION: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide. © 2015 S. Karger AG, Basel. PMID: 26044574 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 2, 2015 Category: Urology & Nephrology Authors: Shah S, Hruskova Z, Segelmark M, Morgan MD, Hogan J, Lee SK, Dale J, Harper L, Tesar V, Jayne DR, Geetha D Tags: Am J Nephrol Source Type: research

Treatment of Severe Renal Disease in ANCA Positive and Negative Small Vessel Vasculitis with Rituximab
Conclusion: Patients with AAV and severe renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide.Am J Nephrol 2015;41:296-301 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2015 Category: Neurology Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States.
CONCLUSIONS: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society. © 2015 S. Karger AG, Basel. PMID: 26044456 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 30, 2015 Category: Urology & Nephrology Authors: Moradi H, Abhari P, Streja E, Kashyap ML, Shah G, Gillen D, Pahl MV, Vaziri ND, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States
Conclusions: Substantial differences exist in the association of serum lipids with mortality in MHD patients of Hispanic background depending on whether they reside on the West or East Coast of the United States. These geographical variances most likely reflect ethnic, racial and genetic distinctions, which are usually ignored. Future studies should take into account these critical variations in a population of patients who make up a significant portion of our society.Am J Nephrol 2015;41:284-295 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 29, 2015 Category: Neurology Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients
Conclusion: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN.Am J Nephrol 2015;41:277-283 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future
Am J Nephrol 2015;41:275-276 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Neurology Source Type: research

Glomerular Structure in Diabetes - Can It Predict the Future?
PMID: 26021407 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: White K Tags: Am J Nephrol Source Type: research

Podocyte Structural Parameters Do Not Predict Progression to Diabetic Nephropathy in Normoalbuminuric Type 1 Diabetic Patients.
CONCLUSION: This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN. © 2015 S. Karger AG, Basel. PMID: 26021523 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2015 Category: Urology & Nephrology Authors: Harindhanavudhi T, Parks A, Mauer M, Caramori ML Tags: Am J Nephrol Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study
Background and Objectives: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR) (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 20, 2015 Category: Neurology Source Type: research

Lifestyle Factors and Indices of Kidney Function in the Framingham Heart Study.
Abstract BACKGROUND AND OBJECTIVES: Lifestyle characteristics are modifiable factors that could be targeted as part of chronic kidney disease (CKD) prevention. We sought to determine the association of lifestyle characteristics with incident estimated glomerular filtration rate (eGFR)
Source: American Journal of Nephrology - May 20, 2015 Category: Urology & Nephrology Authors: Foster MC, Hwang SJ, Massaro JM, Jacques PF, Fox CS, Chu AY Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells.
CONCLUSION: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy. © 2015 S. Karger AG, Basel. PMID: 25924590 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2015 Category: Urology & Nephrology Authors: Cheng M, Liu H, Zhang D, Liu Y, Wang C, Liu F, Chen J Tags: Am J Nephrol Source Type: research

HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells
Conclusion: Our results indicated that AGEs induced HMGB-1 and promoted the CTGF and TGF-β in renal epithelial HK-2 cells RAGE-dependently. And there was a synergism between AGEs and HMGB1 in the RAGE signaling activation. The in vitro data suggested that the AGE-RAGE and HMGB-1-RAGE signaling might play an important role in the promotion of CTGF and TGF-β in the renal fibrosis process of diabetic nephropathy.Am J Nephrol 2015;41:257-266 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 27, 2015 Category: Neurology Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus.
CONCLUSION: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations. © 2015 S. Karger AG, Basel. PMID: 25926050 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Orjuela A, Suwanichkul A, Canter D, Minard CG, Devaraj S, Hicks MJ, Muscal E, Wenderfer SE Tags: Am J Nephrol Source Type: research

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. METHODS: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR ((125)I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. RESULTS: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-...
Source: American Journal of Nephrology - April 25, 2015 Category: Urology & Nephrology Authors: Casteleijn NF, Zittema D, Bakker SJ, Boertien WE, Gaillard CA, Meijer E, Spithoven EM, Struck J, Gansevoort RT Tags: Am J Nephrol Source Type: research

High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus
Conclusion: The addition of anti-basement membrane antibody testing to serologic testing in pSLE may help to monitor disease activity or to define important subsets of patients with risks for specific disease manifestations.Am J Nephrol 2015;41:241-247 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?
This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. Methods: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (125I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. Results: Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m2, TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, ...
Source: American Journal of Nephrology - April 24, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications
Conclusion: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment.Am J Nephrol 2015;41:231-240 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Neurology Source Type: research

Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications.
CONCLUSION: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment. © 2015 S. Karger AG, Basel. PMID: 25896309 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 17, 2015 Category: Urology & Nephrology Authors: Lam NN, Garg AX, Segev DL, Schnitzler MA, Xiao H, Axelrod D, Brennan DC, Kasiske BL, Tuttle-Newhall JE, Lentine KL Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice.
CONCLUSION: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease. © 2015 S. Karger AG, Basel. PMID: 25896231 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 16, 2015 Category: Urology & Nephrology Authors: Ranganathan P, Mohamed R, Jayakumar C, Brands MW, Ramesh G Tags: Am J Nephrol Source Type: research

Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice
Conclusion: Our data suggested that netrin-1 signaling in proximal tubular epithelium may play a critical role in the protection of kidney against diabetic kidney disease.Am J Nephrol 2015;41:220-230 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 15, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy.
ter A, Bjørneklett R Abstract BACKGROUND: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filt...
Source: American Journal of Nephrology - April 9, 2015 Category: Urology & Nephrology Authors: Knoop T, Vågane AM, Vikse BE, Svarstad E, Magnúsdóttir BT, Leh S, Varberg Reisæter A, Bjørneklett R Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy
Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filtration rate (eGFR) and age improved prediction...
Source: American Journal of Nephrology - April 8, 2015 Category: Neurology Source Type: research

Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible.
Abstract Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinico-radiological condition that can result in severe brain injury. The pathogenesis of cerebral vasogenic edema, the hallmark of PRES, is not fully understood. Despite its name, there is substantial heterogeneity both in terms of imaging findings and outcome. Relatively little is known about PRES in kidney disease despite the clustering of risk factors including hypertension, autoimmune disease and immunosuppression. In a retrospective observational study of incident end-stage kidney disease patients in Southwest Ireland over a ten yea...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Canney M, Kelly D, Clarkson M Tags: Am J Nephrol Source Type: research

The Risk of Hyponatremia with Desmopressin Use for Nocturnal Polyuria.
This study was undertaken to characterize hyponatremia occurring in adults using desmopressin for nocturnal polyuria. METHODS: Data from 172 patients who were prescribed desmopressin for nocturnal polyuria at a urology clinic from September 2010 through February 2013 were retrospectively analyzed. Demographic and laboratory parameters were investigated to examine the risk factors for desmopressin-associated hyponatremia. RESULTS: The average follow-up serum sodium measured 21 ± 22 days after using desmopressin was 138 ± 5 mmol/l. Hyponatremia (
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Choi EY, Park JS, Kim YT, Park SY, Kim GH Tags: Am J Nephrol Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
CONCLUSION: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity. © 2015 S. Karger AG, Basel. PMID: 25871823 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Loeser H, von Brandenstein M, Herschung A, Schlosser M, Büttner R, Fries JW Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort.
Abstract BACKGROUND: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. METHODS: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na(+)) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and Na(+) ...
Source: American Journal of Nephrology - April 8, 2015 Category: Urology & Nephrology Authors: Han SW, Tilea A, Gillespie BW, Finkelstein FO, Kiser MA, Eisele G, Kotanko P, Levin N, Saran R Tags: Am J Nephrol Source Type: research

Serum Sodium Levels and Patient Outcomes in an Ambulatory Clinic-Based Chronic Kidney Disease Cohort
Background: Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. Methods: Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum sodium (Na+) and clinical outcomes. Results: Baseline estimated glomerular filtration rate (eGFR) and Na+ were 26 ± 11 ml/min/1.73 ...
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
Conclusion: This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.Am J Nephrol 2015;41:191-199 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

The Risk of Hyponatremia with Desmopressin Use for Nocturnal Polyuria
This study was undertaken to characterize hyponatremia occurring in adults using desmopressin for nocturnal polyuria. Methods: Data from 172 patients who were prescribed desmopressin for nocturnal polyuria at a urology clinic from September 2010 through February 2013 were retrospectively analyzed. Demographic and laboratory parameters were investigated to examine the risk factors for desmopressin-associated hyponatremia. Results: The average follow-up serum sodium measured 21 ± 22 days after using desmopressin was 138 ± 5 mmol/l. Hyponatremia ( (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

Posterior Reversible Encephalopathy Syndrome in End-Stage Kidney Disease: Not Strictly Posterior or Reversible
Posterior reversible encephalopathy syndrome (PRES) is an uncommon clinico-radiological condition that can result in severe brain injury. The pathogenesis of cerebral vasogenic edema, the hallmark of PRES, is not fully understood. Despite its name, there is substantial heterogeneity both in terms of imaging findings and outcome. Relatively little is known about PRES in kidney disease despite the clustering of risk factors including hypertension, autoimmune disease and immunosuppression. In a retrospective observational study of incident end-stage kidney disease patients in Southwest Ireland over a ten year period, we disco...
Source: American Journal of Nephrology - April 7, 2015 Category: Neurology Source Type: research

Associations of Pre-Transplant Prescription Narcotic Use with Clinical Complications after Kidney Transplantation.
We examined integrated national transplant registry, pharmacy records, and Medicare billing claims to follow 16,322 kidney transplant recipients, of whom 28.3% filled a narcotic prescription in the year before transplantation. Opioid analgesic fills were normalized to morphine equivalents (ME) and expressed as mg/kg exposures (approximate quartiles: 0.1-1.7, 1.8-5.4, 5.5-23.7, and ≥23.8 mg/kg, respectively). Post-transplant cardiovascular, respiratory, neurological, accidents, substance abuse, and noncompliance events were identified using diagnosis codes on Medicare billing claims. Adjusted associations of ME level wit...
Source: American Journal of Nephrology - April 3, 2015 Category: Urology & Nephrology Authors: Lentine KL, Lam NN, Xiao H, Tuttle-Newhall JE, Axelrod D, Brennan DC, Dharnidharka VR, Yuan H, Nazzal M, Zheng J, Schnitzler MA Tags: Am J Nephrol Source Type: research

Association between Circulating Thrombopoietin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients
Background/Aims: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoietin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. Methods: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (MVA) was performed betwe...
Source: American Journal of Nephrology - April 3, 2015 Category: Neurology Source Type: research

Associations of Pre-Transplant Prescription Narcotic Use with Clinical Complications after Kidney Transplantation
We examined integrated national transplant registry, pharmacy records, and Medicare billing claims to follow 16,322 kidney transplant recipients, of whom 28.3% filled a narcotic prescription in the year before transplantation. Opioid analgesic fills were normalized to morphine equivalents (ME) and expressed as mg/kg exposures (approximate quartiles: 0.1-1.7, 1.8-5.4, 5.5-23.7, and ≥23.8 mg/kg, respectively). Post-transplant cardiovascular, respiratory, neurological, accidents, substance abuse, and noncompliance events were identified using diagnosis codes on Medicare billing claims. Adjusted associations of ME level wit...
Source: American Journal of Nephrology - March 27, 2015 Category: Neurology Source Type: research

Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Function Decline and Kidney Disease-Related Clinical Events in Older Women.
Abstract BACKGROUND: It is still unclear whether serum neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal tubular injury, is a prognostic marker for the progression of chronic kidney disease (CKD) in the general population. METHODS: A prospective-cohort study of 1,245 women aged ≥70 from the general population. Associations between plasma NGAL and change in 5-year estimated glomerular filtration rate (eGFR), rapid renal decline and 10-year risk of acute or chronic renal disease-related hospitalisations and/or mortality were examined. RESULTS: Compared to women with above-median pl...
Source: American Journal of Nephrology - March 25, 2015 Category: Urology & Nephrology Authors: Lim WH, Lewis JR, Wong G, Teo R, Lim EM, Byrnes E, Prince RL Tags: Am J Nephrol Source Type: research

Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Function Decline and Kidney Disease-Related Clinical Events in Older Women
Background: It is still unclear whether serum neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal tubular injury, is a prognostic marker for the progression of chronic kidney disease (CKD) in the general population. Methods: A prospective-cohort study of 1,245 women aged ≥70 from the general population. Associations between plasma NGAL and change in 5-year estimated glomerular filtration rate (eGFR), rapid renal decline and 10-year risk of acute or chronic renal disease-related hospitalisations and/or mortality were examined. Results: Compared to women with above-median plasma NGAL of 76.5 ng/l, wome...
Source: American Journal of Nephrology - March 24, 2015 Category: Neurology Source Type: research

Association between Circulating Thrombopoeitin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients
Background/Aims: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoeitin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. Methods: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (MVA) was performed betwe...
Source: American Journal of Nephrology - March 20, 2015 Category: Neurology Source Type: research

Association between Circulating Thrombopoeitin Levels and Cardiovascular Risk Prediction Scores in Renal Transplant Recipients.
Abstract BACKGROUND/AIMS: The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoeitin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TPO levels in stable RTR are positively associated with variable(s) in the CRCRTR-MACE score. METHODS: CRCRTR-MACE scores were calculated in 95 stable RTR. TPO levels were measured by multiplexed fluorescent bead-based immunoassay in all patients and 48 controls. Multivariate analysis (M...
Source: American Journal of Nephrology - March 19, 2015 Category: Urology & Nephrology Authors: Mansell H, Elmoselhi H, Shoker A Tags: Am J Nephrol Source Type: research

Hypocalcemia Post Denosumab in Patients with Chronic Kidney Disease Stage 4-5.
CONCLUSIONS: A high rate of severe hypocalcemia was observed in patients with advanced CKD treated with denosumab. If denosumab is used in patients with severe CKD, close monitoring and aggressive replacement of calcium and calcitriol is required to avoid the development of hypocalcemia. © 2015 S. Karger AG, Basel. PMID: 25790847 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 18, 2015 Category: Urology & Nephrology Authors: Dave V, Chiang CY, Booth J, Mount PF Tags: Am J Nephrol Source Type: research

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan.
Abstract BACKGROUND: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. METHODS: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis...
Source: American Journal of Nephrology - March 18, 2015 Category: Urology & Nephrology Authors: Wakasugi M, Kazama JJ, Narita I, Konta T, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Asahi K, Kimura K, Kondo M, Kurahashi I, Ohashi Y, Watanabe T Tags: Am J Nephrol Source Type: research

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan
Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine th...
Source: American Journal of Nephrology - March 17, 2015 Category: Neurology Source Type: research

Hypocalcemia Post Denosumab in Patients with Chronic Kidney Disease Stage 4-5
Conclusions: A high rate of severe hypocalcemia was observed in patients with advanced CKD treated with denosumab. If denosumab is used in patients with severe CKD, close monitoring and aggressive replacement of calcium and calcitriol is required to avoid the development of hypocalcemia.Am J Nephrol 2015;41:129-137 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 17, 2015 Category: Neurology Source Type: research

CKD in Disadvantaged Populations.
PMID: 25766137 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2015 Category: Urology & Nephrology Authors: Garcia-Garcia G, Jha V Tags: Am J Nephrol Source Type: research

One-Year Mortality Rates in US Children with End-Stage Renal Disease.
CONCLUSIONS: One-year mortality rates differ by treatment modality in pediatric ESRD patients. © 2015 S. Karger AG, Basel. PMID: 25766310 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 7, 2015 Category: Urology & Nephrology Authors: Chavers BM, Molony JT, Solid CA, Rheault MN, Collins AJ Tags: Am J Nephrol Source Type: research

CKD in Disadvantaged Populations
Am J Nephrol 2015;41:116-120 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 6, 2015 Category: Neurology Source Type: research

One-Year Mortality Rates in US Children with End-Stage Renal Disease
Conclusions: One-year mortality rates differ by treatment modality in pediatric ESRD patients.Am J Nephrol 2015;41:121-128 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 6, 2015 Category: Neurology Source Type: research

Fasting Plasma Glucose Levels Predict Steroid-Induced Abnormal Glucose Metabolism in Patients with Non-Diabetic Chronic Kidney Disease: A Prospective Cohort Study.
Abstract BACKGROUND/AIMS: Glucocorticoids-induced abnormal glucose metabolism (AGM) is a common medical problem in patients with non-diabetic chronic kidney disease (CKD). However, little information is available regarding the prediction of steroid-induced AGM in this patient population. METHODS: In this prospective cohort study, we consecutively enrolled 303 non-diabetic CKD patients with fasting plasma glucose (FPG) levels
Source: American Journal of Nephrology - March 4, 2015 Category: Urology & Nephrology Authors: Yang X, Lin X, Lu T, Chen P, Wang X, Hou FF Tags: Am J Nephrol Source Type: research

Fasting Plasma Glucose Levels Predict Steroid-Induced Abnormal Glucose Metabolism in Patients with Non-Diabetic Chronic Kidney Disease: A Prospective Cohort Study
Background/Aims: Glucocorticoids-induced abnormal glucose metabolism (AGM) is a common medical problem in patients with non-diabetic chronic kidney disease (CKD). However, little information is available regarding the prediction of steroid-induced AGM in this patient population. Methods: In this prospective cohort study, we consecutively enrolled 303 non-diabetic CKD patients with fasting plasma glucose (FPG) levels (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 3, 2015 Category: Neurology Source Type: research

Clinicopathologic Features of IgA-Dominant Infection-Associated Glomerulonephritis: A Pooled Analysis of 78 Cases
Conclusions: IgA-dominant IAGN has unique clinicopathological manifestations and treatment responses. Age and DM are independent risk factors associated with an unfavorable prognosis for IgA-dominant IAGN.Am J Nephrol 2015;41:98-106 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - March 3, 2015 Category: Neurology Source Type: research