Anti-Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy.
Abstract BACKGROUND: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R-Ab enzyme-linked immunosorbent assay (ELISA) in patients with IMN. METHODS: We measured PLA2R-Ab with an ELISA kit from the serum of 160 patients with IMN (n = 93), secondary MN (n = 14) and other glomerulonephritis (n = 41) as well as healthy controls (n = 12) at the time of renal biopsy and investigated the correlation of titers of PLA2R-Ab with clinical parameters. RESULTS: PLA2R-Ab was positive in 41 of 93 patients (44...
Source: American Journal of Nephrology - October 21, 2015 Category: Urology & Nephrology Authors: Kim YG, Choi YW, Kim SY, Moon JY, Ihm CG, Lee TW, Jeong KH, Yang SH, Kim YS, Oh YJ, Lee SH Tags: Am J Nephrol Source Type: research

Anti-Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy
Background: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R-Ab enzyme-linked immunosorbent assay (ELISA) in patients with IMN. Methods: We measured PLA2R-Ab with an ELISA kit from the serum of 160 patients with IMN (n = 93), secondary MN (n = 14) and other glomerulonephritis (n = 41) as well as healthy controls (n = 12) at the time of renal biopsy and investigated the correlation of titers of PLA2R-Ab with clinical parameters. Results: PLA2R-Ab was positive in 41 of 93 patients (44.1%) with IMN. No samples fr...
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Predictive Value of Atrial Electromechanical Delay on Long-Term Cardiovascular Outcomes in Hemodialysis Patients
Conclusions: Increased LIAT and inflammation were found to be closely associated with 2 years combined CV events and all-cause mortality in HD patients.Am J Nephrol 2015;42:239-249 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Cardiac Electromechanical Abnormalities in Hemodialysis Patients: Indicators of Cardiomyopathy and Future Risk?
Am J Nephrol 2015;42:237-238 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Trends in Anemia Management in Hemodialysis Patients with Cancer.
CONCLUSIONS: Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed. PMID: 26439712 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Butler AM, Kshirsagar AV, Olshan AF, Nielsen ME, Wheeler SB, Brookhart MA Tags: Am J Nephrol Source Type: research

Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury.
CONCLUSION: In our study, we first demonstrated the ability of SPE to reduce proteinuria, preserve the morphology and structure of podocytes and retain the levels of slit diaphragm proteins on PAN-induced rat podocytes injury. PMID: 26439819 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Dai DS, Liu X, Yang Y, Luo XM, Tang RX, Yin ZC, Ren HQ Tags: Am J Nephrol Source Type: research

Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors.
Abstract BACKGROUND: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be ...
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Cozzolino M, Covic A, Martinez-Placencia B, Xynos K Tags: Am J Nephrol Source Type: research

Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors
Background: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be used to define the...
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury
Conclusion: In our study, we first demonstrated the ability of SPE to reduce proteinuria, preserve the morphology and structure of podocytes and retain the levels of slit diaphragm proteins on PAN-induced rat podocytes injury.Am J Nephrol 2015;42:216-227 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Trends in Anemia Management in Hemodialysis Patients with Cancer
Conclusions: Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed.Am J Nephrol 2015;42:206-215 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Association of P-Wave Dispersion with Overall and Cardiovascular Mortality in Hemodialysis Patients
Conclusions: We concluded that PWdisperC was positively associated with overall and cardiovascular mortalities in hemodialysis patients and could provide additional prognostic values. Screening hemodialysis patients by using PWdisperC may facilitate identifying a group of patients with poor prognosis.Am J Nephrol 2015;42:198-205 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 2, 2015 Category: Neurology Source Type: research

Association of P-Wave Dispersion with Overall and Cardiovascular Mortality in Hemodialysis Patients.
CONCLUSIONS: We concluded that PWdisperC was positively associated with overall and cardiovascular mortalities in hemodialysis patients and could provide additional prognostic values. Screening hemodialysis patients by using PWdisperC may facilitate identifying a group of patients with poor prognosis. PMID: 26422319 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 1, 2015 Category: Urology & Nephrology Authors: Chen SC, Su HM, Huang JC, Chang K, Tsai YC, Chen LI, Chang JM, Hwang SJ, Chen HC Tags: Am J Nephrol Source Type: research

Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis
Conclusion: These data points toward the role of TLR3/BAFF axis in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with virus infection results in impaired mucosal and systemic IgA responses.Am J Nephrol 2015;42:185-197 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Neurology Source Type: research

End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases
Conclusion: Patients with FGN have comparable dialysis and renal transplant outcomes to patients with other causes of ESKD. IG patients have inferior survival on dialysis, although renal transplant outcomes are acceptable. Disease recurrence in renal-allografts was low for both FGN and IG.Am J Nephrol 2015;42:177-184 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Neurology Source Type: research

Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis.
CONCLUSION: These data points toward the role of TLR3/BAFF axis in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with virus infection results in impaired mucosal and systemic IgA responses. PMID: 26417991 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Urology & Nephrology Authors: He L, Peng X, Wang J, Tang C, Zhou X, Liu H, Liu F, Sun L, Peng Y Tags: Am J Nephrol Source Type: research

End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases.
CONCLUSION: Patients with FGN have comparable dialysis and renal transplant outcomes to patients with other causes of ESKD. IG patients have inferior survival on dialysis, although renal transplant outcomes are acceptable. Disease recurrence in renal-allografts was low for both FGN and IG. PMID: 26418732 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Urology & Nephrology Authors: Mallett A, Tang W, Hart G, McDonald SP, Hawley CM, Badve SV, Boudville N, Brown FG, Campbell SB, Clayton PA, Johnson DW Tags: Am J Nephrol Source Type: research

MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury
Conclusion: This study indicated that miR-34a might regulate the autophagic activity and can cause injury in I/R RTECs via targeting Atg4B.Am J Nephrol 2015;42:168-175 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Neurology Source Type: research

Improved Mortality Prediction in Dialysis Patients Using Specific Clinical and Laboratory Data
Conclusion: A simple model based on registry data was enhanced by adding easily available clinical parameters.Am J Nephrol 2015;42:158-167 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Neurology Source Type: research

Improved Mortality Prediction in Dialysis Patients Using Specific Clinical and Laboratory Data.
CONCLUSION: A simple model based on registry data was enhanced by adding easily available clinical parameters. PMID: 26406283 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Urology & Nephrology Authors: Hemke AC, Heemskerk MB, van Diepen M, Dekker FW, Hoitsma AJ Tags: Am J Nephrol Source Type: research

MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury.
CONCLUSION: This study indicated that miR-34a might regulate the autophagic activity and can cause injury in I/R RTECs via targeting Atg4B. PMID: 26406385 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Urology & Nephrology Authors: Liu XJ, Hong Q, Wang Z, Yu YY, Zou X, Xu LH Tags: Am J Nephrol Source Type: research

Impact of Non-Adherence on Renal and Cardiovascular Outcomes in US Veterans
Conclusions: Assignment of V15.81 code prior to AHD therapy was associated with higher risks of renal and cardiovascular outcomes in incident hypertensive US veterans. Previous history of non-adherence is a poor prognostic marker in hypertensive individuals; therefore, patients with V15.81 code may require close monitoring. The observational nature of this study limits our ability to make firm recommendations for clinical practice.Am J Nephrol 2015;42:151-157 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2015 Category: Neurology Source Type: research

Non-Adherence Codes in the New ICD-10: Need for Prospective Trials
Am J Nephrol 2015;42:148-150 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2015 Category: Neurology Source Type: research

Impact of Non-Adherence on Renal and Cardiovascular Outcomes in US Veterans.
CONCLUSIONS: Assignment of V15.81 code prior to AHD therapy was associated with higher risks of renal and cardiovascular outcomes in incident hypertensive US veterans. Previous history of non-adherence is a poor prognostic marker in hypertensive individuals; therefore, patients with V15.81 code may require close monitoring. The observational nature of this study limits our ability to make firm recommendations for clinical practice. PMID: 26398170 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2015 Category: Urology & Nephrology Authors: Gosmanova EO, Molnar MZ, Alrifai A, Lu JL, Streja E, Cushman WC, Kalantar-Zadeh K, Kovesdy CP Tags: Am J Nephrol Source Type: research

Non-Adherence Codes in the New ICD-10: Need for Prospective Trials.
PMID: 26398206 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2015 Category: Urology & Nephrology Authors: Baines LS, Little DJ, Nee R, Jindal RM Tags: Am J Nephrol Source Type: research

A Risk Score to Guide Cystatin C Testing to Detect Occult-Reduced Estimated Glomerular Filtration Rate
Background/Aims: Persons with occult-reduced estimated glomerular filtration rate (eGFR 60 ml/min/1.73 m2), tools to guide cystatin C testing are needed. Methods: We developed a risk score to estimate an individual's probability of reduced eGFR by cystatin C (eGFRcys (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2015 Category: Neurology Source Type: research

Association of Self-Reported Frailty with Falls and Fractures among Patients New to Dialysis
Conclusion: Participants reporting frailty experienced nearly twice the risk of medically urgent falls or fractures compared to those who did not report frailty.Am J Nephrol 2015;42:134-140 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2015 Category: Neurology Source Type: research

Association of Self-Reported Frailty with Falls and Fractures among Patients New to Dialysis.
CONCLUSION: Participants reporting frailty experienced nearly twice the risk of medically urgent falls or fractures compared to those who did not report frailty. PMID: 26381744 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 19, 2015 Category: Urology & Nephrology Authors: Delgado C, Shieh S, Grimes B, Chertow GM, Dalrymple LS, Kaysen GA, Kornak J, Johansen KL Tags: Am J Nephrol Source Type: research

A Risk Score to Guide Cystatin C Testing to Detect Occult-Reduced Estimated Glomerular Filtration Rate.
Abstract BACKGROUND/AIMS: Persons with occult-reduced estimated glomerular filtration rate (eGFR 60 ml/min/1.73 m2), tools to guide cystatin C testing are needed. METHODS: We developed a risk score to estimate an individual's probability of reduced eGFR by cystatin C (eGFRcys
Source: American Journal of Nephrology - September 19, 2015 Category: Urology & Nephrology Authors: Peralta CA, Muntner P, Scherzer R, Judd S, Cushman M, Shlipak MG Tags: Am J Nephrol Source Type: research

Eccentric Left Ventricular Hypertrophy and Sudden Death in Patients with End-Stage Kidney Disease
Conclusions: (1) The hazard for all-cause mortality, cardiovascular mortality and sudden death is markedly increased in patients with LVH. (2) The sudden death risk is significantly higher in ESKD patients with eccentric LVH compared to subjects with concentric LVH.Am J Nephrol 2015;42:126-133 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 18, 2015 Category: Neurology Source Type: research

Eccentric Left Ventricular Hypertrophy and Sudden Death in Patients with End-Stage Kidney Disease.
CONCLUSIONS: (1) The hazard for all-cause mortality, cardiovascular mortality and sudden death is markedly increased in patients with LVH. (2) The sudden death risk is significantly higher in ESKD patients with eccentric LVH compared to subjects with concentric LVH. PMID: 26382055 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 18, 2015 Category: Urology & Nephrology Authors: de Roij van Zuijdewijn CL, Hansildaar R, Bots ML, Blankestijn PJ, van den Dorpel MA, Grooteman MP, Kamp O, Ter Wee PM, Nubé MJ Tags: Am J Nephrol Source Type: research

Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients.
CONCLUSION: PlGF is independently associated with mortality and cardiovascular events, but the association between VEGF and adverse events was attenuated with covariate adjustment. The addition of PlGF to models with established clinical predictors provides additional useful prognostic information in patients receiving dialysis. PMID: 26368550 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 15, 2015 Category: Urology & Nephrology Authors: Matsui M, Samejima KI, Takeda Y, Tanabe K, Morimoto K, Okamoto K, Tagawa M, Onoue K, Okayama S, Kawata H, Kawakami R, Akai Y, Saito Y Tags: Am J Nephrol Source Type: research

Placental Growth Factor as a Novel Marker in Uremia-Related Cardiovascular Disease.
PMID: 26368672 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 15, 2015 Category: Urology & Nephrology Authors: Chen CW, Karumanchi SA Tags: Am J Nephrol Source Type: research

Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients
Conclusion: PlGF is independently associated with mortality and cardiovascular events, but the association between VEGF and adverse events was attenuated with covariate adjustment. The addition of PlGF to models with established clinical predictors provides additional useful prognostic information in patients receiving dialysis.Am J Nephrol 2015;42:117-125 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2015 Category: Neurology Source Type: research

Placental Growth Factor as a Novel Marker in Uremia-Related Cardiovascular Disease
Am J Nephrol 2015;42:115-116 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 14, 2015 Category: Neurology Source Type: research

Plasma Copeptin and Decline in Renal Function in a Cohort from the Community: The Prospective D.E.S.I.R. Study
Conclusion: The plasma copeptin level was independently and positively associated with progression towards CKD in a community-based cohort. Our results add to the available evidence for a deleterious effect of high vasopressin on renal health not only in selected groups of patients with CKD but also in the general population.Am J Nephrol 2015;42:107-114 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 11, 2015 Category: Neurology Source Type: research

Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy.
Abstract BACKGROUND: The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD). To prevent disease progression, patients at high risk to develop ESRD are treated with immunosuppressive agents. Therefore, a correct selection of patients who need immunosuppressive treatment is important. METHODS: Here, we evaluated the prognostic value of anti-phospholipase A2 receptor 1 antibody (anti-PLA2R) levels regarding clinical outcome in a well-de...
Source: American Journal of Nephrology - September 9, 2015 Category: Urology & Nephrology Authors: Timmermans SA, Abdul Hamid MA, Cohen Tervaert JW, Damoiseaux JG, van Paassen P, Limburg Renal Registry Tags: Am J Nephrol Source Type: research

Plasma Copeptin and Decline in Renal Function in a Cohort from the Community: The Prospective D.E.S.I.R. Study.
CONCLUSION: The plasma copeptin level was independently and positively associated with progression towards CKD in a community-based cohort. Our results add to the available evidence for a deleterious effect of high vasopressin on renal health not only in selected groups of patients with CKD but also in the general population. PMID: 26346607 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 9, 2015 Category: Urology & Nephrology Authors: Roussel R, Matallah N, Bouby N, El Boustany R, Potier L, Fumeron F, Mohammedi K, Balkau B, Marre M, Bankir L, Velho G Tags: Am J Nephrol Source Type: research

Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression.
Abstract BACKGROUND: In African Americans (AAs), APOL1 G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern. Additional risk and protective genetic variants may be present near the APOL1 loci, since earlier age ESKD is observed in some AAs with one APOL1 renal-risk variant, and because the adjacent gene MYH9 is associated with nephropathy in populations lacking G1 and G2 variants. METHODS: Re-sequencing was performed across a ∼275 kb region encompassing the APOL1-APOL4 and MYH9 genes in 154 AA cases with non-diabetic ESKD an...
Source: American Journal of Nephrology - September 8, 2015 Category: Urology & Nephrology Authors: Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD Tags: Am J Nephrol Source Type: research

Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy
Background: The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD). To prevent disease progression, patients at high risk to develop ESRD are treated with immunosuppressive agents. Therefore, a correct selection of patients who need immunosuppressive treatment is important. Methods: Here, we evaluated the prognostic value of anti-phospholipase A2 receptor 1 antibody (anti-PLA2R) levels regarding clinical outcome in a well-defined cohort of 73 PLA2...
Source: American Journal of Nephrology - September 7, 2015 Category: Neurology Source Type: research

Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression
Background: In African Americans (AAs), APOL1 G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern. Additional risk and protective genetic variants may be present near the APOL1 loci, since earlier age ESKD is observed in some AAs with one APOL1 renal-risk variant, and because the adjacent gene MYH9 is associated with nephropathy in populations lacking G1 and G2 variants. Methods: Re-sequencing was performed across a ∼275 kb region encompassing the APOL1-APOL4 and MYH9 genes in 154 AA cases with non-diabetic ESKD and 38 controls without n...
Source: American Journal of Nephrology - September 7, 2015 Category: Neurology Source Type: research

Serum β2-Microglobulin Predicts Mortality in Peritoneal Dialysis Patients: A Prospective Cohort Study.
CONCLUSIONS: These results are supportive of the potential role of the serum β2-M level as a predictor of mortality in PD patients. PMID: 26339999 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2015 Category: Urology & Nephrology Authors: Koh ES, Lee K, Kim SH, Kim YO, Jin DC, Song HC, Choi EJ, Kim YL, Kim YS, Kang SW, Kim NH, Yang CW, Kim YK Tags: Am J Nephrol Source Type: research

Two Novel HOGA1 Splicing Mutations Identified in a Chinese Patient with Primary Hyperoxaluria Type 3.
CONCLUSION: Two novel HOGA1 mutations were identified in association with PH3. This is the first description and investigation on mutant gene analysis of PH3 in an Asian. PMID: 26340091 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2015 Category: Urology & Nephrology Authors: Wang X, Zhao X, Wang X, Yao J, Zhang F, Lang Y, Tuffery-Giraud S, Bottillo I, Shao L Tags: Am J Nephrol Source Type: research

Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review.
CONCLUSION: The prevalence of HNF1B mutations and the relative contribution of hypomagnesemia to its symptoms are underestimated. Therefore, patients with primary renal magnesium wasting should be tested for HNF1B mutations to ensure early detection and optimal management of ADTKD-HNF1B. PMID: 26340261 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2015 Category: Urology & Nephrology Authors: van der Made CI, Hoorn EJ, de la Faille R, Karaaslan H, Knoers NV, Hoenderop JG, Vargas Poussou R, de Baaij JH Tags: Am J Nephrol Source Type: research

Serum β2-Microglobulin Predicts Mortality in Peritoneal Dialysis Patients: A Prospective Cohort Study
Conclusions: These results are supportive of the potential role of the serum β2-M level as a predictor of mortality in PD patients.Am J Nephrol 2015;42:91-98 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review
Conclusion: The prevalence of HNF1B mutations and the relative contribution of hypomagnesemia to its symptoms are underestimated. Therefore, patients with primary renal magnesium wasting should be tested for HNF1B mutations to ensure early detection and optimal management of ADTKD-HNF1B.Am J Nephrol 2015;42:85-90 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

Two Novel HOGA1 Splicing Mutations Identified in a Chinese Patient with Primary Hyperoxaluria Type 3
Conclusion: Two novel HOGA1 mutations were identified in association with PH3. This is the first description and investigation on mutant gene analysis of PH3 in an Asian.Am J Nephrol 2015;42:78-84 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs
Conclusions: Using a multicenter database of AKI patients requiring CRRT, this study externally validated new AKI severity scores. While the Demirjian's score and Liano's score showed a better performance, further research will be required to confirm these findings.Am J Nephrol 2015;42:57-64 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Contents Vol. 41, 2015
Am J Nephrol 2015;41:I-VI (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Sildenafil for the Treatment of Congenital Nephrogenic Diabetes Insipidus
Conclusions: Sildenafil citrate should be considered an alternative agent in the treatment of X-linked NDI resistant to conventional therapy.Am J Nephrol 2015;42:65-69 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Sildenafil for the Treatment of Congenital Nephrogenic Diabetes Insipidus.
CONCLUSIONS: Sildenafil citrate should be considered an alternative agent in the treatment of X-linked NDI resistant to conventional therapy. © 2015 S. Karger AG, Basel. PMID: 26337818 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Urology & Nephrology Authors: Assadi F, Ghane Sharbaf F Tags: Am J Nephrol Source Type: research