Intradialytic Blood Pressure Abnormalities: The Highs, The Lows and All That Lies Between.
We present evidence associating intradialytic BP phenomena including fall, rise and variability with adverse clinical outcomes and review related pathophysiologic mechanisms and potential management strategies. SUMMARY: Observational studies demonstrate associations between intradialytic hypotension, hypertension and BP variability and mortality. Lack of consensus regarding diagnostic criteria has hampered data synthesis, and prospective studies investigating optimal management strategies for BP phenomena are lacking. Mechanistic data suggest that cardiac, gut, kidney and brain ischemia may lie on the causal pathway b...
Source: American Journal of Nephrology - November 20, 2015 Category: Urology & Nephrology Authors: Assimon MM, Flythe JE Tags: Am J Nephrol Source Type: research

Impact of Poverty and Health Care Insurance on Arteriovenous Fistula Use among Incident Hemodialysis Patients
Background: The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiated on HD. Methods: In this retrospective cohort study using the United States Renal Data System database, we identified 669,206 patients initiated on maintenance HD from January 1, 2007 through December 31, 2012. We assessed the Medicare-Medicaid dual-eligibility status as an indicator of individual-level pov...
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Oxidative Balance Score and Chronic Kidney Disease
Background: The oxidative balance score (OBS) is a composite estimate of the overall pro- and antioxidant exposure status in an individual. The aim of this study was to determine the association between OBS and renal disease. Methods: Using the Reasons for Geographic and Racial Differences in Stroke cohort study, OBS was calculated by combining 13 a priori-defined pro- and antioxidant factors by using baseline dietary and lifestyle assessment. OBS was divided into quartiles (Q1-Q4) with the lowest quartile, Q1 (predominance of pro-oxidants), as the reference. Multivariable logistic regression and Cox proportional hazards m...
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Antioxidants Therapy for Patients with Chronic Kidney Disease: A Question of Balance
Am J Nephrol 2015;42:318-319 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 17, 2015 Category: Neurology Source Type: research

Oxidative Balance Score and Chronic Kidney Disease.
Abstract BACKGROUND: The oxidative balance score (OBS) is a composite estimate of the overall pro- and antioxidant exposure status in an individual. The aim of this study was to determine the association between OBS and renal disease. METHODS: Using the Reasons for Geographic and Racial Differences in Stroke cohort study, OBS was calculated by combining 13 a priori-defined pro- and antioxidant factors by using baseline dietary and lifestyle assessment. OBS was divided into quartiles (Q1-Q4) with the lowest quartile, Q1 (predominance of pro-oxidants), as the reference. Multivariable logistic regression and Cox...
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Ilori TO, Sun Ro Y, Kong SY, Gutierrez OM, Ojo AO, Judd SE, Narayan KM, Goodman M, Plantinga L, McClellan W Tags: Am J Nephrol Source Type: research

Antioxidants Therapy for Patients with Chronic Kidney Disease: A Question of Balance.
PMID: 26569480 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Chen J, Siriki R Tags: Am J Nephrol Source Type: research

Impact of Poverty and Health Care Insurance on Arteriovenous Fistula Use among Incident Hemodialysis Patients.
Abstract BACKGROUND: The impact of socioeconomic factors on arteriovenous fistula (AVF) creation in hemodialysis (HD) patients is not well understood. We assessed the association of area and individual-level indicators of poverty and health care insurance on AVF use among incident end-stage renal disease (ESRD) patients initiated on HD. METHODS: In this retrospective cohort study using the United States Renal Data System database, we identified 669,206 patients initiated on maintenance HD from January 1, 2007 through December 31, 2012. We assessed the Medicare-Medicaid dual-eligibility status as an indicator ...
Source: American Journal of Nephrology - November 17, 2015 Category: Urology & Nephrology Authors: Nee R, Moon DS, Jindal RM, Hurst FP, Yuan CM, Agodoa LY, Abbott KC Tags: Am J Nephrol Source Type: research

Clinical Outcomes in Patients with Severe Renal Dysfunction Including Dialysis Following Defibrillator Implantation
Background: Renal dysfunction is associated with increased mortality in heart failure (HF) patients. However, there are limited data regarding clinical and arrhythmic outcomes associated with implantable cardioverter defibrillator (ICD) therapy in this population. Methods: We evaluated outcomes associated with the severity of renal dysfunction with or without dialysis among 2,289 patients who were enrolled and prospectively followed up in the Israeli ICD Registry. The primary endpoint of the study was all-cause mortality. Secondary endpoints included cardiac mortality, HF hospitalization, non-cardiac hospitalization, and a...
Source: American Journal of Nephrology - November 4, 2015 Category: Neurology Source Type: research

Clinical Outcomes in Patients with Severe Renal Dysfunction Including Dialysis Following Defibrillator Implantation.
Abstract BACKGROUND: Renal dysfunction is associated with increased mortality in heart failure (HF) patients. However, there are limited data regarding clinical and arrhythmic outcomes associated with implantable cardioverter defibrillator (ICD) therapy in this population. METHODS: We evaluated outcomes associated with the severity of renal dysfunction with or without dialysis among 2,289 patients who were enrolled and prospectively followed up in the Israeli ICD Registry. The primary endpoint of the study was all-cause mortality. Secondary endpoints included cardiac mortality, HF hospitalization, non-cardiac...
Source: American Journal of Nephrology - October 31, 2015 Category: Urology & Nephrology Authors: Bogdan S, Nof E, Eisen A, Sela R, Rosenheck S, Freedberg N, Geist M, Ben-Zvi S, Haim M, Glikson M, Goldenberg I, Suleiman M, Israeli working group of pacing and electrophysiology of the Israeli Heart Society Tags: Am J Nephrol Source Type: research

Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages.
CONCLUSION: Taken together, our findings show that endotoxemia results in activation of mTOR signaling in macrophages, leading to progressive kidney inflammatory injuries and subsequent fibrosis. Our study may reveal a mechanism involved in the development of sepsis-associated CKD and kidney fibrosis. PMID: 26517816 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 31, 2015 Category: Urology & Nephrology Authors: Chen H, Zhu J, Liu Y, Dong Z, Liu H, Liu Y, Zhou X, Liu F, Chen G Tags: Am J Nephrol Source Type: research

Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages
Conclusion: Taken together, our findings show that endotoxemia results in activation of mTOR signaling in macrophages, leading to progressive kidney inflammatory injuries and subsequent fibrosis. Our study may reveal a mechanism involved in the development of sepsis-associated CKD and kidney fibrosis.Am J Nephrol 2015;42:305-317 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 30, 2015 Category: Neurology Source Type: research

Intervention Associated Acute Kidney Injury and Long-Term Cardiovascular Outcomes
Background: Acute kidney injury (AKI) has been associated with all-cause short- and long-term mortality. However, its association with cardiovascular (CV) events remains unclear. We sought to investigate this in patients undergoing open (OAR) or endovascular (EVAR) abdominal aortic aneurysm repair, as they are likely to develop both AKI and CV morbidity. A meta-analysis was subsequently performed to confirm this in other CV-interventions. Methods: AKI-incidence was assessed in a multicentre-cohort of 1,068 patients undergoing EVAR (947 individuals) or OAR electively using the ‘Acute Kidney Injury Network' criteria. A...
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Acute Kidney Injury: A Modifiable Risk Factor for Cardiovascular Morbidity and Mortality
Am J Nephrol 2015;42:282-284 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease
Conclusion: Lifestyle modification is feasible in obese patients with CKD and produces weight loss that is related to improvements in exercise capacity, insulin resistance and adipokines. Whether lifestyle-induced weight loss and fitness can be sustained and whether it will mediate improvements in kidney function over time merits further investigation.Am J Nephrol 2015;42:274-281 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Paricalcitol, Microvascular and Endothelial Function in Non-Diabetic Chronic Kidney Disease: A Randomized Trial
Conclusions: Endothelial function declined significantly over 3 months in patients with moderate CKD, and this decline could be ameliorated by VDRA treatment (NCT01204528).Am J Nephrol 2015;42:265-273 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Association Analysis of the Reticulon 1 Gene in End-Stage Kidney Disease
Conclusions: These results suggest evidence of genetic association between common variants in RTN1 and ESKD in AAs and EAs.Am J Nephrol 2015;42:259-264 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Neurology Source Type: research

Intervention Associated Acute Kidney Injury and Long-Term Cardiovascular Outcomes.
Abstract BACKGROUND: Acute kidney injury (AKI) has been associated with all-cause short- and long-term mortality. However, its association with cardiovascular (CV) events remains unclear. We sought to investigate this in patients undergoing open (OAR) or endovascular (EVAR) abdominal aortic aneurysm repair, as they are likely to develop both AKI and CV morbidity. A meta-analysis was subsequently performed to confirm this in other CV-interventions. METHODS: AKI-incidence was assessed in a multicentre-cohort of 1,068 patients undergoing EVAR (947 individuals) or OAR electively using the 'Acute Kidney Injury Net...
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Saratzis A, Harrison S, Barratt J, Sayers RD, Sarafidis PA, Bown MJ Tags: Am J Nephrol Source Type: research

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease.
CONCLUSION: Lifestyle modification is feasible in obese patients with CKD and produces weight loss that is related to improvements in exercise capacity, insulin resistance and adipokines. Whether lifestyle-induced weight loss and fitness can be sustained and whether it will mediate improvements in kidney function over time merits further investigation. PMID: 26495987 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Navaneethan SD, Fealy CE, Scelsi AC, Arrigain S, Malin SK, Kirwan JP Tags: Am J Nephrol Source Type: research

Association Analysis of the Reticulon 1 Gene in End-Stage Kidney Disease.
CONCLUSIONS: These results suggest evidence of genetic association between common variants in RTN1 and ESKD in AAs and EAs. PMID: 26496126 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Bonomo JA, Palmer ND, He JC, Fan Y, Hicks PJ, Lea JP, Okusa MD, Bowden DW, Freedman BI Tags: Am J Nephrol Source Type: research

Paricalcitol, Microvascular and Endothelial Function in Non-Diabetic Chronic Kidney Disease: A Randomized Trial.
CONCLUSIONS: Endothelial function declined significantly over 3 months in patients with moderate CKD, and this decline could be ameliorated by VDRA treatment (NCT01204528). PMID: 26496210 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Lundwall K, Jörneskog G, Jacobson SH, Spaak J Tags: Am J Nephrol Source Type: research

Acute Kidney Injury: A Modifiable Risk Factor for Cardiovascular Morbidity and Mortality.
PMID: 26496654 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 24, 2015 Category: Urology & Nephrology Authors: Alreja G, Koyner JL Tags: Am J Nephrol Source Type: research

Cardiac Electromechanical Abnormalities in Hemodialysis Patients: Indicators of Cardiomyopathy and Future Risk.
PMID: 26484657 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2015 Category: Urology & Nephrology Authors: Fallahzadeh MK, McCullough PA Tags: Am J Nephrol Source Type: research

Predictive Value of Atrial Electromechanical Delay on Long-Term Cardiovascular Outcomes in Hemodialysis Patients.
CONCLUSIONS: Increased LIAT and inflammation were found to be closely associated with 2 years combined CV events and all-cause mortality in HD patients. PMID: 26484658 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 21, 2015 Category: Urology & Nephrology Authors: Turkmen K, Demirtas L, Topal E, Gaipov A, Kocyigit I, Orscelik O, Guney I, Kılıc S, Yilmaz MI Tags: Am J Nephrol Source Type: research

Anti-Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy.
Abstract BACKGROUND: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R-Ab enzyme-linked immunosorbent assay (ELISA) in patients with IMN. METHODS: We measured PLA2R-Ab with an ELISA kit from the serum of 160 patients with IMN (n = 93), secondary MN (n = 14) and other glomerulonephritis (n = 41) as well as healthy controls (n = 12) at the time of renal biopsy and investigated the correlation of titers of PLA2R-Ab with clinical parameters. RESULTS: PLA2R-Ab was positive in 41 of 93 patients (44...
Source: American Journal of Nephrology - October 21, 2015 Category: Urology & Nephrology Authors: Kim YG, Choi YW, Kim SY, Moon JY, Ihm CG, Lee TW, Jeong KH, Yang SH, Kim YS, Oh YJ, Lee SH Tags: Am J Nephrol Source Type: research

Anti-Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy
Background: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R-Ab enzyme-linked immunosorbent assay (ELISA) in patients with IMN. Methods: We measured PLA2R-Ab with an ELISA kit from the serum of 160 patients with IMN (n = 93), secondary MN (n = 14) and other glomerulonephritis (n = 41) as well as healthy controls (n = 12) at the time of renal biopsy and investigated the correlation of titers of PLA2R-Ab with clinical parameters. Results: PLA2R-Ab was positive in 41 of 93 patients (44.1%) with IMN. No samples fr...
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Predictive Value of Atrial Electromechanical Delay on Long-Term Cardiovascular Outcomes in Hemodialysis Patients
Conclusions: Increased LIAT and inflammation were found to be closely associated with 2 years combined CV events and all-cause mortality in HD patients.Am J Nephrol 2015;42:239-249 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Cardiac Electromechanical Abnormalities in Hemodialysis Patients: Indicators of Cardiomyopathy and Future Risk?
Am J Nephrol 2015;42:237-238 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 20, 2015 Category: Neurology Source Type: research

Trends in Anemia Management in Hemodialysis Patients with Cancer.
CONCLUSIONS: Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed. PMID: 26439712 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Butler AM, Kshirsagar AV, Olshan AF, Nielsen ME, Wheeler SB, Brookhart MA Tags: Am J Nephrol Source Type: research

Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury.
CONCLUSION: In our study, we first demonstrated the ability of SPE to reduce proteinuria, preserve the morphology and structure of podocytes and retain the levels of slit diaphragm proteins on PAN-induced rat podocytes injury. PMID: 26439819 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Dai DS, Liu X, Yang Y, Luo XM, Tang RX, Yin ZC, Ren HQ Tags: Am J Nephrol Source Type: research

Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors.
Abstract BACKGROUND: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be ...
Source: American Journal of Nephrology - October 7, 2015 Category: Urology & Nephrology Authors: Cozzolino M, Covic A, Martinez-Placencia B, Xynos K Tags: Am J Nephrol Source Type: research

Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors
Background: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be used to define the...
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury
Conclusion: In our study, we first demonstrated the ability of SPE to reduce proteinuria, preserve the morphology and structure of podocytes and retain the levels of slit diaphragm proteins on PAN-induced rat podocytes injury.Am J Nephrol 2015;42:216-227 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Trends in Anemia Management in Hemodialysis Patients with Cancer
Conclusions: Despite safety concerns about ESAs in both the ESRD and cancer populations, the proportion of hemodialysis patients with cancer who used ESAs between 2000 and 2011 remained extremely high. EPO dose and hemoglobin levels increased and then decreased. Iron use, iron dose, and transfusions increased substantially. Future research examining the risk-benefit profile of different anemia management strategies in the dialysis population with cancer is needed.Am J Nephrol 2015;42:206-215 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 6, 2015 Category: Neurology Source Type: research

Association of P-Wave Dispersion with Overall and Cardiovascular Mortality in Hemodialysis Patients
Conclusions: We concluded that PWdisperC was positively associated with overall and cardiovascular mortalities in hemodialysis patients and could provide additional prognostic values. Screening hemodialysis patients by using PWdisperC may facilitate identifying a group of patients with poor prognosis.Am J Nephrol 2015;42:198-205 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 2, 2015 Category: Neurology Source Type: research

Association of P-Wave Dispersion with Overall and Cardiovascular Mortality in Hemodialysis Patients.
CONCLUSIONS: We concluded that PWdisperC was positively associated with overall and cardiovascular mortalities in hemodialysis patients and could provide additional prognostic values. Screening hemodialysis patients by using PWdisperC may facilitate identifying a group of patients with poor prognosis. PMID: 26422319 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 1, 2015 Category: Urology & Nephrology Authors: Chen SC, Su HM, Huang JC, Chang K, Tsai YC, Chen LI, Chang JM, Hwang SJ, Chen HC Tags: Am J Nephrol Source Type: research

Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis
Conclusion: These data points toward the role of TLR3/BAFF axis in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with virus infection results in impaired mucosal and systemic IgA responses.Am J Nephrol 2015;42:185-197 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Neurology Source Type: research

End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases
Conclusion: Patients with FGN have comparable dialysis and renal transplant outcomes to patients with other causes of ESKD. IG patients have inferior survival on dialysis, although renal transplant outcomes are acceptable. Disease recurrence in renal-allografts was low for both FGN and IG.Am J Nephrol 2015;42:177-184 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Neurology Source Type: research

Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis.
CONCLUSION: These data points toward the role of TLR3/BAFF axis in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with virus infection results in impaired mucosal and systemic IgA responses. PMID: 26417991 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Urology & Nephrology Authors: He L, Peng X, Wang J, Tang C, Zhou X, Liu H, Liu F, Sun L, Peng Y Tags: Am J Nephrol Source Type: research

End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases.
CONCLUSION: Patients with FGN have comparable dialysis and renal transplant outcomes to patients with other causes of ESKD. IG patients have inferior survival on dialysis, although renal transplant outcomes are acceptable. Disease recurrence in renal-allografts was low for both FGN and IG. PMID: 26418732 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 30, 2015 Category: Urology & Nephrology Authors: Mallett A, Tang W, Hart G, McDonald SP, Hawley CM, Badve SV, Boudville N, Brown FG, Campbell SB, Clayton PA, Johnson DW Tags: Am J Nephrol Source Type: research

MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury
Conclusion: This study indicated that miR-34a might regulate the autophagic activity and can cause injury in I/R RTECs via targeting Atg4B.Am J Nephrol 2015;42:168-175 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Neurology Source Type: research

Improved Mortality Prediction in Dialysis Patients Using Specific Clinical and Laboratory Data
Conclusion: A simple model based on registry data was enhanced by adding easily available clinical parameters.Am J Nephrol 2015;42:158-167 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Neurology Source Type: research

Improved Mortality Prediction in Dialysis Patients Using Specific Clinical and Laboratory Data.
CONCLUSION: A simple model based on registry data was enhanced by adding easily available clinical parameters. PMID: 26406283 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Urology & Nephrology Authors: Hemke AC, Heemskerk MB, van Diepen M, Dekker FW, Hoitsma AJ Tags: Am J Nephrol Source Type: research

MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury.
CONCLUSION: This study indicated that miR-34a might regulate the autophagic activity and can cause injury in I/R RTECs via targeting Atg4B. PMID: 26406385 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 26, 2015 Category: Urology & Nephrology Authors: Liu XJ, Hong Q, Wang Z, Yu YY, Zou X, Xu LH Tags: Am J Nephrol Source Type: research

Impact of Non-Adherence on Renal and Cardiovascular Outcomes in US Veterans
Conclusions: Assignment of V15.81 code prior to AHD therapy was associated with higher risks of renal and cardiovascular outcomes in incident hypertensive US veterans. Previous history of non-adherence is a poor prognostic marker in hypertensive individuals; therefore, patients with V15.81 code may require close monitoring. The observational nature of this study limits our ability to make firm recommendations for clinical practice.Am J Nephrol 2015;42:151-157 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2015 Category: Neurology Source Type: research

Non-Adherence Codes in the New ICD-10: Need for Prospective Trials
Am J Nephrol 2015;42:148-150 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 25, 2015 Category: Neurology Source Type: research

Impact of Non-Adherence on Renal and Cardiovascular Outcomes in US Veterans.
CONCLUSIONS: Assignment of V15.81 code prior to AHD therapy was associated with higher risks of renal and cardiovascular outcomes in incident hypertensive US veterans. Previous history of non-adherence is a poor prognostic marker in hypertensive individuals; therefore, patients with V15.81 code may require close monitoring. The observational nature of this study limits our ability to make firm recommendations for clinical practice. PMID: 26398170 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2015 Category: Urology & Nephrology Authors: Gosmanova EO, Molnar MZ, Alrifai A, Lu JL, Streja E, Cushman WC, Kalantar-Zadeh K, Kovesdy CP Tags: Am J Nephrol Source Type: research

Non-Adherence Codes in the New ICD-10: Need for Prospective Trials.
PMID: 26398206 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 24, 2015 Category: Urology & Nephrology Authors: Baines LS, Little DJ, Nee R, Jindal RM Tags: Am J Nephrol Source Type: research

A Risk Score to Guide Cystatin C Testing to Detect Occult-Reduced Estimated Glomerular Filtration Rate
Background/Aims: Persons with occult-reduced estimated glomerular filtration rate (eGFR 60 ml/min/1.73 m2), tools to guide cystatin C testing are needed. Methods: We developed a risk score to estimate an individual's probability of reduced eGFR by cystatin C (eGFRcys (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2015 Category: Neurology Source Type: research

Association of Self-Reported Frailty with Falls and Fractures among Patients New to Dialysis
Conclusion: Participants reporting frailty experienced nearly twice the risk of medically urgent falls or fractures compared to those who did not report frailty.Am J Nephrol 2015;42:134-140 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 20, 2015 Category: Neurology Source Type: research

Association of Self-Reported Frailty with Falls and Fractures among Patients New to Dialysis.
CONCLUSION: Participants reporting frailty experienced nearly twice the risk of medically urgent falls or fractures compared to those who did not report frailty. PMID: 26381744 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 19, 2015 Category: Urology & Nephrology Authors: Delgado C, Shieh S, Grimes B, Chertow GM, Dalrymple LS, Kaysen GA, Kornak J, Johansen KL Tags: Am J Nephrol Source Type: research