Two Novel HOGA1 Splicing Mutations Identified in a Chinese Patient with Primary Hyperoxaluria Type 3.
CONCLUSION: Two novel HOGA1 mutations were identified in association with PH3. This is the first description and investigation on mutant gene analysis of PH3 in an Asian. PMID: 26340091 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2015 Category: Urology & Nephrology Authors: Wang X, Zhao X, Wang X, Yao J, Zhang F, Lang Y, Tuffery-Giraud S, Bottillo I, Shao L Tags: Am J Nephrol Source Type: research

Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review.
CONCLUSION: The prevalence of HNF1B mutations and the relative contribution of hypomagnesemia to its symptoms are underestimated. Therefore, patients with primary renal magnesium wasting should be tested for HNF1B mutations to ensure early detection and optimal management of ADTKD-HNF1B. PMID: 26340261 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 5, 2015 Category: Urology & Nephrology Authors: van der Made CI, Hoorn EJ, de la Faille R, Karaaslan H, Knoers NV, Hoenderop JG, Vargas Poussou R, de Baaij JH Tags: Am J Nephrol Source Type: research

Serum β2-Microglobulin Predicts Mortality in Peritoneal Dialysis Patients: A Prospective Cohort Study
Conclusions: These results are supportive of the potential role of the serum β2-M level as a predictor of mortality in PD patients.Am J Nephrol 2015;42:91-98 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review
Conclusion: The prevalence of HNF1B mutations and the relative contribution of hypomagnesemia to its symptoms are underestimated. Therefore, patients with primary renal magnesium wasting should be tested for HNF1B mutations to ensure early detection and optimal management of ADTKD-HNF1B.Am J Nephrol 2015;42:85-90 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

Two Novel HOGA1 Splicing Mutations Identified in a Chinese Patient with Primary Hyperoxaluria Type 3
Conclusion: Two novel HOGA1 mutations were identified in association with PH3. This is the first description and investigation on mutant gene analysis of PH3 in an Asian.Am J Nephrol 2015;42:78-84 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - September 4, 2015 Category: Neurology Source Type: research

External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs
Conclusions: Using a multicenter database of AKI patients requiring CRRT, this study externally validated new AKI severity scores. While the Demirjian's score and Liano's score showed a better performance, further research will be required to confirm these findings.Am J Nephrol 2015;42:57-64 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Contents Vol. 41, 2015
Am J Nephrol 2015;41:I-VI (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Sildenafil for the Treatment of Congenital Nephrogenic Diabetes Insipidus
Conclusions: Sildenafil citrate should be considered an alternative agent in the treatment of X-linked NDI resistant to conventional therapy.Am J Nephrol 2015;42:65-69 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Neurology Source Type: research

Sildenafil for the Treatment of Congenital Nephrogenic Diabetes Insipidus.
CONCLUSIONS: Sildenafil citrate should be considered an alternative agent in the treatment of X-linked NDI resistant to conventional therapy. © 2015 S. Karger AG, Basel. PMID: 26337818 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 26, 2015 Category: Urology & Nephrology Authors: Assadi F, Ghane Sharbaf F Tags: Am J Nephrol Source Type: research

Differentiating Glomerular Inflammation from Fibrosis in a Bone Marrow Chimera for Rat Anti-Glomerular Basement Membrane Glomerulonephritis
Conclusion: Inflammation alone was not sufficient to trigger fibrosis, suggesting a critical role of glomerular cells in the fibrotic process. As LEWWKY chimera allows us to separate glomerular inflammation from fibrosis, this model provides a useful tool to study how fibrosis is initiated following inflammation.Am J Nephrol 2015;42:42-53 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 25, 2015 Category: Neurology Source Type: research

Expression of Cell Membrane Antigens in Cells Excreted in the Urinary Sediment Predicts Progression of Renal Disease in Patients with Focal Segmental Glomerulosclerosis
Conclusion: Urinary sediment PDX positive cell numbers do not predict the progression of FSGS, whereas CD68 and Ki67 phenotype of urinary podocytic lineage clearly has a prognostic significance in 36 months' observation of primary FSGS.Am J Nephrol 2015;42:35-41 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 25, 2015 Category: Neurology Source Type: research

Expression of Cell Membrane Antigens in Cells Excreted in the Urinary Sediment Predicts Progression of Renal Disease in Patients with Focal Segmental Glomerulosclerosis.
CONCLUSION: Urinary sediment PDX positive cell numbers do not predict the progression of FSGS, whereas CD68 and Ki67 phenotype of urinary podocytic lineage clearly has a prognostic significance in 36 months' observation of primary FSGS. © 2015 S. Karger AG, Basel. PMID: 26337565 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 25, 2015 Category: Urology & Nephrology Authors: Konieczny A, Czyżewska-Buczyńska A, Ryba M, Rukasz D, Krajewska M, Witkiewicz W, Hruby Z Tags: Am J Nephrol Source Type: research

Differentiating Glomerular Inflammation from Fibrosis in a Bone Marrow Chimera for Rat Anti-Glomerular Basement Membrane Glomerulonephritis.
CONCLUSION: Inflammation alone was not sufficient to trigger fibrosis, suggesting a critical role of glomerular cells in the fibrotic process. As LEW(WKY) chimera allows us to separate glomerular inflammation from fibrosis, this model provides a useful tool to study how fibrosis is initiated following inflammation. © 2015 S. Karger AG, Basel. PMID: 26337665 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 25, 2015 Category: Urology & Nephrology Authors: Zhou C, Lou K, Tatum K, Funk J, Wu J, Bartkowiak T, Kagan D, Lou Y Tags: Am J Nephrol Source Type: research

External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs.
CONCLUSIONS: Using a multicenter database of AKI patients requiring CRRT, this study externally validated new AKI severity scores. While the Demirjian's score and Liano's score showed a better performance, further research will be required to confirm these findings. © 2015 S. Karger AG, Basel. PMID: 26337793 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 22, 2015 Category: Urology & Nephrology Authors: Ohnuma T, Uchino S, Toki N, Takeda K, Namba Y, Katayama S, Kawarazaki H, Yasuda H, Izawa J, Uji M, Tokuhira N, Nagata I Tags: Am J Nephrol Source Type: research

Predicting Mortality after Severe Acute Kidney Injury: A Step Forward but Not Close to the Finish Line.
PMID: 26303823 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 22, 2015 Category: Urology & Nephrology Authors: Sharma S, Navaneethan SD Tags: Am J Nephrol Source Type: research

Predicting Mortality after Severe Acute Kidney Injury: A Step Forward but Not Close to the Finish Line
Am J Nephrol 2015;42:54-56 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 21, 2015 Category: Neurology Source Type: research

Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis
Conclusions: Aberrant phosphorus homeostasis, reflected by higher phosphorus and FGF23, may be a risk factor for mortality in patients initiating hemodialysis, particularly among African Americans.Am J Nephrol 2015;42:25-34 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2015 Category: Neurology Source Type: research

Why Is the Association of Phosphorus and FGF23 with Mortality Stronger in African-American Hemodialysis Patients?
Am J Nephrol 2015;42:22-24 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2015 Category: Neurology Source Type: research

Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis.
CONCLUSIONS: Aberrant phosphorus homeostasis, reflected by higher phosphorus and FGF23, may be a risk factor for mortality in patients initiating hemodialysis, particularly among African Americans. PMID: 26287973 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2015 Category: Urology & Nephrology Authors: Scialla JJ, Parekh RS, Eustace JA, Astor BC, Plantinga L, Jaar BG, Shafi T, Coresh J, Powe NR, Melamed ML Tags: Am J Nephrol Source Type: research

Why Is the Association of Phosphorus and FGF23 with Mortality Stronger in African-American Hemodialysis Patients?
PMID: 26288017 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2015 Category: Urology & Nephrology Authors: Lau WL, Kalantar-Zadeh K Tags: Am J Nephrol Source Type: research

Serum S100A12: A Risk Marker or Risk Factor of Vascular Calcification in Chronic Kidney Disease
Am J Nephrol 2015;42:1-3 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 14, 2015 Category: Neurology Source Type: research

Sodium Citrate Inhibits Endoplasmic Reticulum Stress in Rats with Adenine-Induced Chronic Renal Failure
Conclusions: Sodium citrate has a protective effect on CRF through its effects on ERS.Am J Nephrol 2015;42:14-21 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 14, 2015 Category: Neurology Source Type: research

Serum S100A12: A Risk Marker or Risk Factor of Vascular Calcification in Chronic Kidney Disease?
PMID: 26278719 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 13, 2015 Category: Urology & Nephrology Authors: Lindholm B Tags: Am J Nephrol Source Type: research

Serum S100A12 and Progression of Coronary Artery Calcification Over 4 Years in Hemodialysis Patients.
Abstract BACKGROUND/AIM: Vascular calcification is common and contributes to increased cardiovascular mortality in hemodialysis (HD) patients. In this prospective study, we aimed to investigate the associations of serum S100A12 in the presence of severe coronary artery calcification (CAC) and the progression of CAC in HD patients. METHODS: Sixty maintenance HD patients and 30 controls were enrolled. Serum S100A12 levels were measured using ELISA. CAC scores (CACs) were measured twice at a 4-year interval using multislice spiral CT. The HD patients were classified as rapid progressors or slow progressors accor...
Source: American Journal of Nephrology - August 13, 2015 Category: Urology & Nephrology Authors: Wang YN, Sun Y, Wang Y, Jia YL Tags: Am J Nephrol Source Type: research

Serum S100A12 and Progression of Coronary Artery Calcification Over 4 Years in Hemodialysis Patients
Background/Aim: Vascular calcification is common and contributes to increased cardiovascular mortality in hemodialysis (HD) patients. In this prospective study, we aimed to investigate the associations of serum S100A12 in the presence of severe coronary artery calcification (CAC) and the progression of CAC in HD patients. Methods: Sixty maintenance HD patients and 30 controls were enrolled. Serum S100A12 levels were measured using ELISA. CAC scores (CACs) were measured twice at a 4-year interval using multislice spiral CT. The HD patients were classified as rapid progressors or slow progressors according to the change in t...
Source: American Journal of Nephrology - August 12, 2015 Category: Neurology Source Type: research

Serum S100A12: A Risk Marker or Risk Factor of Vascular Calcification in Chronic Kidney Disease?
Am J Nephrol 2015;42:1-3 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 12, 2015 Category: Neurology Source Type: research

Do the Eyes Reveal More Than Scleral Icterus in Sickle Cell Disease
Am J Nephrol 2015;41:485-486 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 7, 2015 Category: Neurology Source Type: research

Dialysis Facility Transplant Philosophy and Access to Kidney Transplantation in the Southeast
Conclusions: Facilities with staff who had a more positive transplant philosophy were more likely to have better facility waitlisting performance. Future prospective studies are needed to further investigate if improving the kidney transplant philosophy in dialysis facilities improves access to transplantation.Am J Nephrol 2015;41:504-511 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 7, 2015 Category: Neurology Source Type: research

Access to Kidney Transplantation: Is There a Potential Conflict of Interest
Am J Nephrol 2015;41:502-503 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 7, 2015 Category: Neurology Source Type: research

Access to Kidney Transplantation: Is There a Potential Conflict of Interest?
PMID: 26278422 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 6, 2015 Category: Urology & Nephrology Authors: Rubin MF, Weir MR Tags: Am J Nephrol Source Type: research

Dialysis Facility Transplant Philosophy and Access to Kidney Transplantation in the Southeast.
CONCLUSIONS: Facilities with staff who had a more positive transplant philosophy were more likely to have better facility waitlisting performance. Future prospective studies are needed to further investigate if improving the kidney transplant philosophy in dialysis facilities improves access to transplantation. © 2015 S. Karger AG, Basel. PMID: 26278585 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 6, 2015 Category: Urology & Nephrology Authors: Gander J, Browne T, Plantinga L, Pastan SO, Sauls L, Krisher J, Patzer RE Tags: Am J Nephrol Source Type: research

Do the Eyes Reveal More Than Scleral Icterus in Sickle Cell Disease?
PMID: 26277980 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 5, 2015 Category: Urology & Nephrology Authors: Pittman CA, Fitzhugh CD Tags: Am J Nephrol Source Type: research

Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy.
Abstract BACKGROUND: Albuminuria is an early manifestation of deterioration in renal function in subjects with sickle cell disease (SCD). Hyperfiltration may be an early mechanism for kidney damage in SCD. The purpose of the current study was to determine the association between conjunctival hemodynamics and albuminuria in SCD subjects with preserved glomerular filtration rate. METHODS: Conjunctival microcirculation imaging was performed to measure conjunctival diameter and axial blood velocity (V) in 35 SCD and 10 healthy control subjects. Albuminuria, defined as albumin excretion ratio (AER), was obtained f...
Source: American Journal of Nephrology - August 5, 2015 Category: Urology & Nephrology Authors: Kord Valeshabad A, Wanek J, Saraf SL, Gaynes BI, Gordeuk VR, Molokie RE, Shahidi M Tags: Am J Nephrol Source Type: research

Total Convection Affects Serum β2 Microglobulin and C-Reactive Protein but Not Erythropoietin Requirement following Post-Dilutional Hemodiafiltration.
Total Convection Affects Serum β2 Microglobulin and C-Reactive Protein but Not Erythropoietin Requirement following Post-Dilutional Hemodiafiltration. Am J Nephrol. 2015 Aug 5;41(6):494-501 Authors: Movilli E, Camerini C, Gaggia P, Zubani R, Feller P, Salviani C, Facchini A, Cancarini G Abstract BACKGROUND: Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which de...
Source: American Journal of Nephrology - August 5, 2015 Category: Urology & Nephrology Authors: Movilli E, Camerini C, Gaggia P, Zubani R, Feller P, Salviani C, Facchini A, Cancarini G Tags: Am J Nephrol Source Type: research

Total Convection Affects Serum β2 Microglobulin and C-Reactive Protein but Not Erythropoietin Requirement following Post-Dilutional Hemodiafiltration
Background: Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which depurative component plays a major role in determining this result. The aim of the study was to evaluate the role of convection and diffusion on long-term variations of serum β2 microglobulin (#x0394;β2M), high-sensitive C-reactive protein (#x0394;hsCRP) concentrations, and ESA requirement (#x0394;ESA) in ol-HDF. M...
Source: American Journal of Nephrology - August 4, 2015 Category: Neurology Source Type: research

Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy
Background: Albuminuria is an early manifestation of deterioration in renal function in subjects with sickle cell disease (SCD). Hyperfiltration may be an early mechanism for kidney damage in SCD. The purpose of the current study was to determine the association between conjunctival hemodynamics and albuminuria in SCD subjects with preserved glomerular filtration rate. Methods: Conjunctival microcirculation imaging was performed to measure conjunctival diameter and axial blood velocity (V) in 35 SCD and 10 healthy control subjects. Albuminuria, defined as albumin excretion ratio (AER), was obtained from the medical charts....
Source: American Journal of Nephrology - August 4, 2015 Category: Neurology Source Type: research

Do the Eyes Reveal More Than Scleral Icterus in Sickle Cell Disease?
Am J Nephrol 2015;41:485-486 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 4, 2015 Category: Neurology Source Type: research

Pre-Transplant Weight Loss and Survival after Kidney Transplantation
We examined post-transplant survival among obese kidney candidates who were temporarily designated waitlist inactive (status 7) due to their weight. Methods: Using OPTN/United Network for Organ Sharing data, patient and graft survival of adult status 7 recipients with a registration body mass index (BMI) ≥30 kg/m2 (n = 328) were compared to all others (controls; n = 74,066). Status 7 recipients were then matched to controls to assess whether pre-transplant weight loss was associated with a survival benefit. Results: Median BMI at registration (38 vs. 27 kg/m2, p
Source: American Journal of Nephrology - July 25, 2015 Category: Neurology Source Type: research

Pro-Apoptotic Effects of Plasma from Patients with Cardiorenal Syndrome on Human Tubular Cells
This study seeks to provide insight into the pathophysiological pathways in CRS1; we evaluated in vitro the effects of CRS1 plasma on TECs. Methods: We enrolled 40 acute HF patients and 15 controls (CTR) without HF or acute kidney injury (AKI). Ten out of 40 HF patients exhibited AKI at the time of admission for HF or developed AKI during hospitalization and were classified as CRS1. In vitro, cell viability, DNA fragmentation and caspase-3 levels were investigated in TECs incubated with HF, CRS1, and CTR plasma. We assessed inflammatory cytokines and NGAL expression at the gene and protein levels. Results: We observed a ma...
Source: American Journal of Nephrology - July 25, 2015 Category: Neurology Source Type: research

Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation
Background: Low turnover bone (low bone formation rates (BFRs)) with decreased osteoblast number is common in patients with chronic kidney disease (CKD) and attributed to ‘over-suppression' of the parathyroid hormone (PTH) despite supra-physiologic levels. An alternative hypothesis is abnormal osteoblast differentiation, resulting in low BFRs due to reduced VEGF-A. Methods: We analyzed the expression of VEGF-A and mesenchymal stem cell (MSC) differentiation factors in freshly isolated bone marrow (BM) cells, and in BM cell-derived MSC in rats with different levels of BFRs and PTH (modulated by calcium and zoledronic ...
Source: American Journal of Nephrology - July 25, 2015 Category: Neurology Source Type: research

Serum Potassium, End-Stage Renal Disease and Mortality in Chronic Kidney Disease
Background/Aims: Hypokalemia and hyperkalemia are often noted in chronic kidney disease (CKD) patients, but their impact on mortality and end-stage renal disease (ESRD) is less well understood. We aimed at studying the associations between potassium disorders, and mortality and progression to ESRD in a CKD population. Methods: Using our electronic health record-based CKD registry, 36,359 patients with eGFR (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 25, 2015 Category: Neurology Source Type: research

Electrochemical Skin Conductance in Diabetic Kidney Disease
Conclusions: ESC measured using Sudoscan® is strongly associated with DKD in African Americans and European Americans. ESC is a useful screening test to identify DKD in patients with T2D.Am J Nephrol 2015;41:438-447 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 25, 2015 Category: Neurology Source Type: research

Electrochemical Skin Conductance in Diabetic Kidney Disease.
Abstract BACKGROUND: There is a need to identify patients with diabetic kidney disease (DKD) using noninvasive, cost-effective screening tests. Sudoscan®, a device using electrochemical skin conductance (ESC) to measure sweat gland dysfunction, is valuable for detecting peripheral neuropathy. ESC was tested for association with DKD (estimated glomerular filtration rate (eGFR)
Source: American Journal of Nephrology - July 25, 2015 Category: Urology & Nephrology Authors: Freedman BI, Smith SC, Bagwell BM, Xu J, Bowden DW, Divers J Tags: Am J Nephrol Source Type: research

Pre-Transplant Weight Loss and Survival after Kidney Transplantation.
We examined post-transplant survival among obese kidney candidates who were temporarily designated waitlist inactive (status 7) due to their weight. METHODS: Using OPTN/United Network for Organ Sharing data, patient and graft survival of adult status 7 recipients with a registration body mass index (BMI) ≥30 kg/m(2) (n = 328) were compared to all others (controls; n = 74,066). Status 7 recipients were then matched to controls to assess whether pre-transplant weight loss was associated with a survival benefit. RESULTS: Median BMI at registration (38 vs. 27 kg/m(2), p
Source: American Journal of Nephrology - July 25, 2015 Category: Urology & Nephrology Authors: Huang E, Bunnapradist S Tags: Am J Nephrol Source Type: research

Serum Potassium, End-Stage Renal Disease and Mortality in Chronic Kidney Disease.
Abstract BACKGROUND/AIMS: Hypokalemia and hyperkalemia are often noted in chronic kidney disease (CKD) patients, but their impact on mortality and end-stage renal disease (ESRD) is less well understood. We aimed at studying the associations between potassium disorders, and mortality and progression to ESRD in a CKD population. METHODS: Using our electronic health record-based CKD registry, 36,359 patients with eGFR
Source: American Journal of Nephrology - July 25, 2015 Category: Urology & Nephrology Authors: Nakhoul GN, Huang H, Arrigain S, Jolly SE, Schold JD, Nally JV, Navaneethan SD Tags: Am J Nephrol Source Type: research

Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation.
Abstract BACKGROUND: Low turnover bone (low bone formation rates (BFRs)) with decreased osteoblast number is common in patients with chronic kidney disease (CKD) and attributed to 'over-suppression' of the parathyroid hormone (PTH) despite supra-physiologic levels. An alternative hypothesis is abnormal osteoblast differentiation, resulting in low BFRs due to reduced VEGF-A. METHODS: We analyzed the expression of VEGF-A and mesenchymal stem cell (MSC) differentiation factors in freshly isolated bone marrow (BM) cells, and in BM cell-derived MSC in rats with different levels of BFRs and PTH (modulated by calciu...
Source: American Journal of Nephrology - July 25, 2015 Category: Urology & Nephrology Authors: Chen NX, O'Neill KD, Allen MR, Newman CL, Moe SM Tags: Am J Nephrol Source Type: research

Pro-Apoptotic Effects of Plasma from Patients with Cardiorenal Syndrome on Human Tubular Cells.
This study seeks to provide insight into the pathophysiological pathways in CRS1; we evaluated in vitro the effects of CRS1 plasma on TECs. METHODS: We enrolled 40 acute HF patients and 15 controls (CTR) without HF or acute kidney injury (AKI). Ten out of 40 HF patients exhibited AKI at the time of admission for HF or developed AKI during hospitalization and were classified as CRS1. In vitro, cell viability, DNA fragmentation and caspase-3 levels were investigated in TECs incubated with HF, CRS1, and CTR plasma. We assessed inflammatory cytokines and NGAL expression at the gene and protein levels. RESULTS: We obs...
Source: American Journal of Nephrology - July 25, 2015 Category: Urology & Nephrology Authors: Virzì GM, de Cal M, Day S, Brocca A, Cruz DN, Castellani C, Cantaluppi V, Bolin C, Fedrigo M, Thiene G, Valente M, Angelini A, Vescovo G, Ronco C Tags: Am J Nephrol Source Type: research

Renal Function and Long-Term Decline in Cognitive Function: The Baltimore Longitudinal Study of Aging.
Abstract BACKGROUND: Renal disease has been associated with greater risk of dementia and greater cognitive impairment. However, the relationship of lower renal function with long-term decline in specific domains of cognitive function remains unclear among community-dwelling, non-demented individuals. METHODS: Stroke- and dementia-free participants (n = 2,116) were enrolled in the Baltimore Longitudinal Study of Aging, a community-based, prospective, longitudinal study. Renal function was estimated by the inverse of serum creatinine adjusted for age, sex and race and (in sensitivity analyses) estimated glomeru...
Source: American Journal of Nephrology - July 24, 2015 Category: Urology & Nephrology Authors: Seliger SL, Wendell CR, Waldstein SR, Ferrucci L, Zonderman AB Tags: Am J Nephrol Source Type: research

Can We Improve Dialysis Arteriovenous Graft Survival?
Am J Nephrol 2015;41:418-419 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 22, 2015 Category: Neurology Source Type: research

Treatment and Outcome of Primary and Secondary Thrombotic Microangiopathies.
PMID: 26183157 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 14, 2015 Category: Urology & Nephrology Authors: Eskazan AE, Salihoglu A Tags: Am J Nephrol Source Type: research