Complement-C1q TNF-Related Protein 3 Alleviates Mesangial Cell Activation and Inflammatory Response Stimulated by Secretory IgA
Conclusion: CTRP3 potentially targeted to NF-#x03BA;B and TGF-β-Src-Smad3 signaling and exerted anti-inflammatory and anti-fibrotic roles to attenuate the progression of IgAN, which may represent a new strategy for the treatment of IgAN.Am J Nephrol 2016;43:460-468 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 17, 2016 Category: Neurology Source Type: research

Complement-C1q TNF-Related Protein 3 Alleviates Mesangial Cell Activation and Inflammatory Response Stimulated by Secretory IgA.
CONCLUSION: CTRP3 potentially targeted to NF-x03BA;B and TGF-β-Src-Smad3 signaling and exerted anti-inflammatory and anti-fibrotic roles to attenuate the progression of IgAN, which may represent a new strategy for the treatment of IgAN. PMID: 27309491 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 16, 2016 Category: Urology & Nephrology Authors: Zhang R, Zhong L, Zhou J, Peng Y Tags: Am J Nephrol Source Type: research

Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1
Conclusion: Urine MCP-1 may detect early tubulointerstitial fibrosis in adults with normal kidney function.Am J Nephrol 2016;43:454-459 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 10, 2016 Category: Neurology Source Type: research

Urinary Chemoattractant Protein 1: A New Biomarker of Renal Fibrosis
Am J Nephrol 2016;43:451-453 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 10, 2016 Category: Neurology Source Type: research

Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1.
CONCLUSION: Urine MCP-1 may detect early tubulointerstitial fibrosis in adults with normal kidney function. PMID: 27288357 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 9, 2016 Category: Urology & Nephrology Authors: Wang X, Lieske JC, Alexander MP, Jayachandran M, Denic A, Mathew J, Lerman LO, Kremers WK, Larson JJ, Rule AD Tags: Am J Nephrol Source Type: research

Urinary Chemoattractant Protein 1: A New Biomarker of Renal Fibrosis.
PMID: 27288367 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 9, 2016 Category: Urology & Nephrology Authors: Glassock RJ Tags: Am J Nephrol Source Type: research

Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics.
CONCLUSION: HO-1 is a putative regulator of proteins important in preserving glomerular structural stability and integrity, and in minimizing the activity of proinflammatory pathways. PMID: 27251563 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2016 Category: Urology & Nephrology Authors: Detsika MG, Lygirou V, Frantzis V, Zoidakis J, Atsaves V, Poulaki E, Gakiopoulou H, Vlahou A, Lianos EA Tags: Am J Nephrol Source Type: research

Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics
Conclusion: HO-1 is a putative regulator of proteins important in preserving glomerular structural stability and integrity, and in minimizing the activity of proinflammatory pathways.Am J Nephrol 2016;43:441-450 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - June 1, 2016 Category: Neurology Source Type: research

Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study
Conclusions: In a large CKD study, serum bicarbonate was associated with LV mass and concentric LVH; however, this association was attenuated after adjustment for clinical factors suggesting that the observed cardiac effects are mediated through yet unknown mechanisms.Am J Nephrol 2016;43:411-420 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 31, 2016 Category: Neurology Source Type: research

Does an Acid-Milieu in Chronic Kidney Disease Contribute to Its Increased Cardiovascular Mortality
Am J Nephrol 2016;43:408-410 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 30, 2016 Category: Neurology Source Type: research

Obesity, Renin-Angiotensin System Blockade and Risk of Adverse Renal Outcomes: A Population-Based Cohort Study
Conclusion: This study, conducted in a large real-world cohort, provides evidence that RAS blockade may not provide benefit with regard to longitudinal renal outcomes in obese, hypertensive patients. Further research is needed to elucidate the hemodynamic and renoprotective role of antihypertensive medications in obese patients.Am J Nephrol 2016;43:431-440 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 28, 2016 Category: Neurology Source Type: research

Furosemide Increases the Risk of Hyperparathyroidism in Chronic Kidney Disease
Conclusion: Furo increased the risk of HPT2 among CKD patients compared to Hydro. This effect was independent of eGFR or calcium excretion. The use of LD in CKD, currently preferred in advanced stages, should be reappraised.Am J Nephrol 2016;43:421-430 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 28, 2016 Category: Neurology Source Type: research

Does an Acid-Milieu in Chronic Kidney Disease Contribute to Its Increased Cardiovascular Mortality?
Am J Nephrol 2016;43:408-410 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 28, 2016 Category: Neurology Source Type: research

Vitamin D in Kidney Transplant Recipients: Mechanisms and Therapy
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is common in kidney transplant recipients (KTRs), where secondary hyperparathyroidism (HPTH) and post-transplantation bone disease (PTBD) are potential effectors of both graft and vascular aging. Reduced 25(OH)D levels are highly prevalent in KTRs. Experimental and clinical evidence support the direct involvement of deranged vitamin D metabolism in CKD-MBD among KTRs. This review analyzes the pathophysiology of vitamin D derangement in KTRs and its fall out on patient and graft outcome, highlighting the roles of both nutritional and active vitamin D compounds to tr...
Source: American Journal of Nephrology - May 28, 2016 Category: Neurology Source Type: research

Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study.
CONCLUSIONS: In a large CKD study, serum bicarbonate was associated with LV mass and concentric LVH; however, this association was attenuated after adjustment for clinical factors suggesting that the observed cardiac effects are mediated through yet unknown mechanisms. PMID: 27241893 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 27, 2016 Category: Urology & Nephrology Authors: Dobre M, Roy J, Tao K, Anderson AH, Bansal N, Chen J, Deo R, Drawz P, Feldman HI, Hamm LL, Hostetter T, Kusek JW, Lora C, Ojo AO, Shrama K, Rahman M, CRIC Study Investigators Tags: Am J Nephrol Source Type: research

Obesity, Renin-Angiotensin System Blockade and Risk of Adverse Renal Outcomes: A Population-Based Cohort Study.
CONCLUSION: This study, conducted in a large real-world cohort, provides evidence that RAS blockade may not provide benefit with regard to longitudinal renal outcomes in obese, hypertensive patients. Further research is needed to elucidate the hemodynamic and renoprotective role of antihypertensive medications in obese patients. PMID: 27228992 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 27, 2016 Category: Urology & Nephrology Authors: Cohen JB, Stephens-Shields AJ, Denburg MR, Anderson AH, Townsend RR, Reese PP Tags: Am J Nephrol Source Type: research

Vitamin D in Kidney Transplant Recipients: Mechanisms and Therapy.
Abstract Chronic kidney disease-mineral and bone disorder (CKD-MBD) is common in kidney transplant recipients (KTRs), where secondary hyperparathyroidism (HPTH) and post-transplantation bone disease (PTBD) are potential effectors of both graft and vascular aging. Reduced 25(OH)D levels are highly prevalent in KTRs. Experimental and clinical evidence support the direct involvement of deranged vitamin D metabolism in CKD-MBD among KTRs. This review analyzes the pathophysiology of vitamin D derangement in KTRs and its fall out on patient and graft outcome, highlighting the roles of both nutritional and active vitamin...
Source: American Journal of Nephrology - May 27, 2016 Category: Urology & Nephrology Authors: Cianciolo G, Galassi A, Capelli I, Angelini ML, La Manna G, Cozzolino M Tags: Am J Nephrol Source Type: research

Does an Acid-Milieu in Chronic Kidney Disease Contribute to Its Increased Cardiovascular Mortality?
PMID: 27229524 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 27, 2016 Category: Urology & Nephrology Authors: Wesson DE Tags: Am J Nephrol Source Type: research

Furosemide Increases the Risk of Hyperparathyroidism in Chronic Kidney Disease.
CONCLUSION: Furo increased the risk of HPT2 among CKD patients compared to Hydro. This effect was independent of eGFR or calcium excretion. The use of LD in CKD, currently preferred in advanced stages, should be reappraised. PMID: 27231243 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 27, 2016 Category: Urology & Nephrology Authors: Vasco RF, Moyses RM, Zatz R, Elias RM Tags: Am J Nephrol Source Type: research

Erratum.
Authors: PMID: 27215747 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 26, 2016 Category: Urology & Nephrology Tags: Am J Nephrol Source Type: research

Living Kidney Donors Who Develop Kidney Failure: Excerpts of Their Thoughts.
CONCLUSIONS: Most donors are positive about their donation decision and experience and would donate again, despite developing ESRD themselves. They propose some important changes to the decision-making and informed-consent processes. Our data are reassuring regarding lack of donor regret, but highlight the need for living donor transplant programs to ensure that living donors understand their long-term risks and receive appropriate life-long follow-up care to minimize these risks. PMID: 27222023 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 24, 2016 Category: Urology & Nephrology Authors: Halverson CM, Wang JY, Poulson M, Karlin J, Crowley-Matoka M, Ross LF Tags: Am J Nephrol Source Type: research

Living Kidney Donors Who Develop Kidney Failure: Excerpts of Their Thoughts
Conclusions: Most donors are positive about their donation decision and experience and would donate again, despite developing ESRD themselves. They propose some important changes to the decision-making and informed-consent processes. Our data are reassuring regarding lack of donor regret, but highlight the need for living donor transplant programs to ensure that living donors understand their long-term risks and receive appropriate life-long follow-up care to minimize these risks.Am J Nephrol 2016;43:389-396 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 24, 2016 Category: Neurology Source Type: research

Erratum
Am J Nephrol 2016;43:225 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 24, 2016 Category: Neurology Source Type: research

Best Albuminuria Measurement to Predict Cardiovascular and Renal Events.
CONCLUSION: Compared to ACR albuminuria categories, eAER categories are better associated with future cardiovascular events, but not with renal events. PMID: 27188712 [PubMed - in process] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 19, 2016 Category: Urology & Nephrology Authors: Bauer L, Emrich IE, Pickering JW, Untersteller K, Sandermann F, Rogacev KS, Seiler-Mussler S, Fliser D, Heine GH Tags: Am J Nephrol Source Type: research

Best Albuminuria Measurement to Predict Cardiovascular and Renal Events
Conclusion: Compared to ACR albuminuria categories, eAER categories are better associated with future cardiovascular events, but not with renal events.Am J Nephrol 2016;43:383-388 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 18, 2016 Category: Neurology Source Type: research

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study.
Abstract BACKGROUND: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. METHODS: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Rhee EP, Clish CB, Wenger J, Roy J, Elmariah S, Pierce KA, Bullock K, Anderson AH, Gerszten RE, Feldman HI Tags: Am J Nephrol Source Type: research

Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway.
CONCLUSION: Reduced Klotho expression aggravates Tac-induced renal injury via the PI3K-Akt-FoxO pathway. PMID: 27174564 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Jin J, Jin L, Lim SW, Yang CW Tags: Am J Nephrol Source Type: research

Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury.
Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury. Am J Nephrol. 2016 May 13;43(5):375-382 Authors: Kimmel M, Shi J, Wasser C, Biegger D, Alscher MD, Schanz MB Abstract BACKGROUND: Urine microscopy is an established technique to assess kidney disease, and can add valuable information about the mechanism of damage. However, it requires the time and expertise of an experienced nephrologist and, therefore, is typically used for a limited number of patients in practice. A rapid biomarker test that identifies patients from the emergency department (ED) who are likely to hav...
Source: American Journal of Nephrology - May 12, 2016 Category: Urology & Nephrology Authors: Kimmel M, Shi J, Wasser C, Biegger D, Alscher MD, Schanz MB Tags: Am J Nephrol Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal
Background: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. Methods: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD-EPIcr,cysc), CKD-EPIcy...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander
Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potent...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Urinary [TIMP-2]·[IGFBP7] - Novel Biomarkers to Predict Acute Kidney Injury
Background: Urine microscopy is an established technique to assess kidney disease, and can add valuable information about the mechanism of damage. However, it requires the time and expertise of an experienced nephrologist and, therefore, is typically used for a limited number of patients in practice. A rapid biomarker test that identifies patients from the emergency department (ED) who are likely to have positive urine microscopy findings would enable more efficient use of this technique. Methods: Four hundred patients were enrolled in the ED; thereof 362 patients had available both tissue inhibitor of metalloproteinases-2...
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study
Background: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. Methods: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway
Conclusion: Reduced Klotho expression aggravates Tac-induced renal injury via the PI3K-Akt-FoxO pathway.Am J Nephrol 2016;43:357-365 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 12, 2016 Category: Neurology Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal?
Background: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. Methods: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD-EPIcr,cysc), CKD-EPIcy...
Source: American Journal of Nephrology - May 11, 2016 Category: Neurology Source Type: research

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal?
Abstract BACKGROUND: Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was reported. To date, however, no study has examined the performance of the BIS2 to predict death in older adults as compared to equations used clinically and in research. METHODS: We prospectively followed 2,994 community-dwelling men (age 76.4 ± 5.6) enrolled in the MrOS Sleep Study. We calculated baseline eGFR from serum creatinine and cystatin-C using the BIS2, Chronic Kidney Disease Epidemiology (CKD...
Source: American Journal of Nephrology - May 11, 2016 Category: Urology & Nephrology Authors: Canales MT, Blackwell T, Ishani A, Taylor BC, Hart A, Barrett-Connor E, Lewis C, Beyth RJ, Stone K, Ensrud KE, Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study Tags: Am J Nephrol Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?
Abstract BACKGROUND: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. SUMMARY: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally,...
Source: American Journal of Nephrology - May 11, 2016 Category: Urology & Nephrology Authors: Desmedt V, Desmedt S, Delanghe JR, Speeckaert R, Speeckaert MM Tags: Am J Nephrol Source Type: research

Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?
Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potent...
Source: American Journal of Nephrology - May 11, 2016 Category: Neurology Source Type: research

Outcomes of IgA Nephropathy with Segmental Glomerular Necrosis But without Crescent Formation.
CONCLUSIONS: SGN can be found in mild pathological damage patients and is not always associated with crescent formation. Heavier proteinuria was found in these IgAN patients. SGN was not an independent predictor for the prognosis of IgAN. PMID: 27166147 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Tan M, Li W, Zou G, Zhang C, Fang J Tags: Am J Nephrol Source Type: research

Reduced Cardiovascular Mortality Associated with Early Vascular Access Placement in Elderly Patients with Chronic Kidney Disease.
Abstract BACKGROUND: Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this consideration. We assessed whether there has been a parallel decrease in cardiovascular comorbidity in elderly chronic kidney disease (CKD) patients undergoing predialysis access surgery, and whether this impacted clinical outcomes after access creation and cardiovascular events after hemo...
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Lee T, Thamer M, Zhang Q, Zhang Y, Allon M Tags: Am J Nephrol Source Type: research

Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy.
Abstract BACKGROUND: Little is known about the endoplasmic reticulum stress (ERS) marker glucose regulated protein 78 (GRP78) and calcineurin in the kidney in primary membranous nephropathy (PMN) and if they could predict post-cyclosporine treatment outcome. METHODS: This is a retrospective study using a dataset of biopsy-confirmed PMN from Peking Union Medical College Hospital from 1996 to 2014. Seventy-six adult patients treated with cyclosporine as primary immunosuppression for at least 6 months were studied. Immunohistochemistry was used to detect GRP78 and calcineurin in the kidney. Serum calcineurin was...
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Tao J, Zhang W, Wen Y, Sun Y, Chen L, Li H, Li M, Li X, Lafayette RA, Li X Tags: Am J Nephrol Source Type: research

Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study.
CONCLUSIONS: The findings of this exploratory study suggest that older patients with high comorbidities and highly complex regimen are more likely to be adherent based on an objective measure. Future research is needed using objective measures of adherence suitable for all patients and reflecting all medications. PMID: 27166159 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Urology & Nephrology Authors: Ghimire S, Peterson GM, Castelino RL, Jose MD, Zaidi ST Tags: Am J Nephrol Source Type: research

Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy
Background: Little is known about the endoplasmic reticulum stress (ERS) marker glucose regulated protein 78 (GRP78) and calcineurin in the kidney in primary membranous nephropathy (PMN) and if they could predict post-cyclosporine treatment outcome. Methods: This is a retrospective study using a dataset of biopsy-confirmed PMN from Peking Union Medical College Hospital from 1996 to 2014. Seventy-six adult patients treated with cyclosporine as primary immunosuppression for at least 6 months were studied. Immunohistochemistry was used to detect GRP78 and calcineurin in the kidney. Serum calcineurin was assayed by ELISA. Pati...
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Outcomes of IgA Nephropathy with Segmental Glomerular Necrosis But without Crescent Formation
Conclusions: SGN can be found in mild pathological damage patients and is not always associated with crescent formation. Heavier proteinuria was found in these IgAN patients. SGN was not an independent predictor for the prognosis of IgAN.Am J Nephrol 2016;43:341-347 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Reduced Cardiovascular Mortality Associated with Early Vascular Access Placement in Elderly Patients with Chronic Kidney Disease
Background: Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this consideration. We assessed whether there has been a parallel decrease in cardiovascular comorbidity in elderly chronic kidney disease (CKD) patients undergoing predialysis access surgery, and whether this impacted clinical outcomes after access creation and cardiovascular events after hemodialysis initiatio...
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study
Conclusions: The findings of this exploratory study suggest that older patients with high comorbidities and highly complex regimen are more likely to be adherent based on an objective measure. Future research is needed using objective measures of adherence suitable for all patients and reflecting all medications.Am J Nephrol 2016;43:318-324 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 10, 2016 Category: Neurology Source Type: research

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria.
Abstract BACKGROUND: Primary hyperoxaluria type 1 (PH1) and idiopathic hypercalciuria (IHC) are stone-forming diseases that may result in the formation of calcium (Ca) oxalate (Ox) stones, nephrocalcinosis, and progressive chronic kidney disease (CKD). Poorer clinical outcome in PH1 is segregated by the highest urine (Ur)-Ox (UrOx), while IHC outcomes are not predictable by UrCa. We hypothesized that differences would be found in selected Ur-protein (PRO) patterns in PH1 and IHC, compared to healthy intra-familial sibling controls (C) of PH1 patients. We also hypothesized that the PRO patterns associated with high...
Source: American Journal of Nephrology - May 2, 2016 Category: Urology & Nephrology Authors: Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB Tags: Am J Nephrol Source Type: research

Hydration and Chronic Kidney Disease Progression: A Critical Review of the Evidence.
Abstract We performed a comprehensive literature review to examine evidence on the effects of hydration on the kidney. By reducing vasopressin secretion, increasing water intake may have a beneficial effect on renal function in patients with all forms of chronic kidney disease (CKD) and in those at risk of CKD. This potential benefit may be greater when the kidney is still able to concentrate urine (high fluid intake is contraindicated in dialysis-dependent patients). Increasing water intake is a well-accepted method for preventing renal calculi, and current evidence suggests that recurrent dehydration and heat st...
Source: American Journal of Nephrology - May 2, 2016 Category: Urology & Nephrology Authors: Clark WF, Sontrop JM, Huang SH, Moist L, Bouby N, Bankir L Tags: Am J Nephrol Source Type: research

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria
Background: Primary hyperoxaluria type 1 (PH1) and idiopathic hypercalciuria (IHC) are stone-forming diseases that may result in the formation of calcium (Ca) oxalate (Ox) stones, nephrocalcinosis, and progressive chronic kidney disease (CKD). Poorer clinical outcome in PH1 is segregated by the highest urine (Ur)-Ox (UrOx), while IHC outcomes are not predictable by UrCa. We hypothesized that differences would be found in selected Ur-protein (PRO) patterns in PH1 and IHC, compared to healthy intra-familial sibling controls (C) of PH1 patients. We also hypothesized that the PRO patterns associated with higher UrOx levels wou...
Source: American Journal of Nephrology - May 2, 2016 Category: Neurology Source Type: research

Hydration and Chronic Kidney Disease Progression: A Critical Review of the Evidence
We performed a comprehensive literature review to examine evidence on the effects of hydration on the kidney. By reducing vasopressin secretion, increasing water intake may have a beneficial effect on renal function in patients with all forms of chronic kidney disease (CKD) and in those at risk of CKD. This potential benefit may be greater when the kidney is still able to concentrate urine (high fluid intake is contraindicated in dialysis-dependent patients). Increasing water intake is a well-accepted method for preventing renal calculi, and current evidence suggests that recurrent dehydration and heat stress from extreme ...
Source: American Journal of Nephrology - May 2, 2016 Category: Neurology Source Type: research

Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease
Background: Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseline CKD. Methods: Using current guideline criteria, 1,726 (36.9%) of 4,678 participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure (BP) arm had mild to moderate CKD (CKD1-3B) at baseline. Participants of this study were randomized to intensive (systolic (Source: American ...
Source: American Journal of Nephrology - April 29, 2016 Category: Neurology Source Type: research