Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Musculoskeletal health worsened from carnitine supplementation and not impacted by a novel individualized treadmill training protocol
CONCLUSION: Carnitine supplementation worsened CKD progression, mineral metabolism biochemistries and cortical porosity, and did not have an impact on physical function. Individualized treadmill running improved maximal aerobic capacity but did not have an impact on CKD progression or bone properties. Future studies should seek to better understand carnitine doses in conditions of compromised renal function to prevent toxicity which may result from elevated carnitine levels and to optimize exercise prescriptions for musculoskeletal health.PMID:38377965 | DOI:10.1159/000537827 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 20, 2024 Category: Urology & Nephrology Authors: Ashley D Troutman Shruthi Srinivasan Corinne E Metzger Paul B Fallen Neal Chen Kalisha D O'Neill Matthew R Allen Annabel Biruete Sharon M Moe Keith G Avin Source Type: research
Erratum
Am J Nephrol. 2024 Feb 16:1. doi: 10.1159/000536477. Online ahead of print.NO ABSTRACTPMID:38368865 | DOI:10.1159/000536477 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 18, 2024 Category: Urology & Nephrology Source Type: research
Erratum
Am J Nephrol. 2024 Feb 16:1. doi: 10.1159/000536477. Online ahead of print.NO ABSTRACTPMID:38368865 | DOI:10.1159/000536477 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 18, 2024 Category: Urology & Nephrology Source Type: research
Availability and quality of dialysis care in rural versus urban U.S. counties
CONCLUSION: The majority of rural counites lack a single dialysis facility. Counties with high rates of chronic kidney disease, diabetes, and blood pressure, deemed high need, were less likely to have a highly rated dialysis facility. The findings can be used to further inform targeted efforts to increase diabetes educational programming and design appropriate interventions to those residing in rural communities and high need counties who may need it the most.PMID:38342081 | DOI:10.1159/000537763 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2024 Category: Urology & Nephrology Authors: Elizabeth Crouch Nick Yell Laura Herbert Teri Browne Peiyin Hung Source Type: research
Availability and quality of dialysis care in rural versus urban U.S. counties
CONCLUSION: The majority of rural counites lack a single dialysis facility. Counties with high rates of chronic kidney disease, diabetes, and blood pressure, deemed high need, were less likely to have a highly rated dialysis facility. The findings can be used to further inform targeted efforts to increase diabetes educational programming and design appropriate interventions to those residing in rural communities and high need counties who may need it the most.PMID:38342081 | DOI:10.1159/000537763 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2024 Category: Urology & Nephrology Authors: Elizabeth Crouch Nick Yell Laura Herbert Teri Browne Peiyin Hung Source Type: research
Availability and quality of dialysis care in rural versus urban U.S. counties
CONCLUSION: The majority of rural counites lack a single dialysis facility. Counties with high rates of chronic kidney disease, diabetes, and blood pressure, deemed high need, were less likely to have a highly rated dialysis facility. The findings can be used to further inform targeted efforts to increase diabetes educational programming and design appropriate interventions to those residing in rural communities and high need counties who may need it the most.PMID:38342081 | DOI:10.1159/000537763 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2024 Category: Urology & Nephrology Authors: Elizabeth Crouch Nick Yell Laura Herbert Teri Browne Peiyin Hung Source Type: research
Availability and quality of dialysis care in rural versus urban U.S. counties
CONCLUSION: The majority of rural counites lack a single dialysis facility. Counties with high rates of chronic kidney disease, diabetes, and blood pressure, deemed high need, were less likely to have a highly rated dialysis facility. The findings can be used to further inform targeted efforts to increase diabetes educational programming and design appropriate interventions to those residing in rural communities and high need counties who may need it the most.PMID:38342081 | DOI:10.1159/000537763 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 11, 2024 Category: Urology & Nephrology Authors: Elizabeth Crouch Nick Yell Laura Herbert Teri Browne Peiyin Hung Source Type: research
Klotho stabilizes the podocyte actin cytoskeleton in idiopathic membranous nephropathy through regulating the TRPC6/CatL pathway
CONCLUSION: Klotho may protect against podocyte injury in IMN patients by inhibiting the TRPC6/CatL pathway. Klotho is a potential target for reducing proteinuria in IMN patients.PMID:38330925 | DOI:10.1159/000537732 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 8, 2024 Category: Urology & Nephrology Authors: Hongyun Wang Hongyan Liu Hong Cheng Xue Xue Yamei Ge Xiaoqin Wang Jun Yuan Source Type: research
Association between serum 25-hydroxyvitamin D levels and sarcopenia in patients undergoing chronic haemodialysis
CONCLUSION: Lower serum 25(OH)D levels were associated with sarcopenia independent of traditional risk factors in patients undergoing haemodialysis with suppressed vitamin D activation in the kidney. This finding implies that circulating 25(OH)D may have an important relationship with the skeletal muscle function of patients undergoing haemodialysis, and its measurement may be recommended to identify patients at high risk for sarcopenia among those undergoing haemodialysis.PMID:38310857 | DOI:10.1159/000536582 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - February 4, 2024 Category: Urology & Nephrology Authors: Mayuko Hori Hiroshi Takahashi Chika Kondo Fumihito Hayashi Shigehiro Tokoroyama Yoshiko Mori Makoto Tsujita Yuichi Shirasawa Asami Takeda Kunio Morozumi Shoichi Maruyama Source Type: research
Difelikefalin in Black/African American Hemodialysis Patients with Moderate-to-Severe Pruritus: Post-hoc Analysis of KALM-1 and KALM-2
Am J Nephrol. 2024 Jan 22. doi: 10.1159/000534227. Online ahead of print.ABSTRACTBlack and African American (AA) people are over-represented in the kidney failure population; therefore, the safety and efficacy of difelikefalin in Black/AA patients was evaluated. This was a post hoc, pooled exploratory subgroup analysis of the Phase 3 KALM-1 and -2 studies. Patients undergoing hemodialysis (HD) who had moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) at enrollment were stratified into self-reported Black/AA or White subgroups. Patients were randomized (1:1) to receive intravenous (IV) difelikefalin 0.5...
Source: American Journal of Nephrology - January 22, 2024 Category: Urology & Nephrology Authors: Steven Fishbane Deborah J Clegg Edgar V Lerma Anjay Rastogi Jeffrey Budden Isabelle Morin Warren Wen Fr édérique Menzaghi Joel Topf Source Type: research
Expression of Concern
Am J Nephrol. 2024 Jan 19:1. doi: 10.1159/000536261. Online ahead of print.NO ABSTRACTPMID:38246139 | DOI:10.1159/000536261 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 21, 2024 Category: Urology & Nephrology Source Type: research
Amide proton transfer-weighted magnetic resonance imaging for application in renal fibrosis: A radiological-pathological based analysis
CONCLUSION: APT values had better diagnostic capability at early stage of RF compared to ADC values, and the addition of APT imaging to conventional ADC will significantly improve the diagnostic performance for predicting kidney fibrosis.PMID:38228096 | DOI:10.1159/000536232 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 16, 2024 Category: Urology & Nephrology Authors: Dan Zhao Wei Wang Yang-Yang Niu Xi-Hui Ren Ai-Jun Shen Yong-Sheng Xiang Hong-Yan Xie Le-Hao Wu Yu Chen Ying-Ying Zhang Source Type: research
Klotho and Mortality in Chronic Kidney Disease: Actor, Risk Factor, or Predictor?
Am J Nephrol. 2024 Jan 10:1-3. doi: 10.1159/000535752. Online ahead of print.NO ABSTRACTPMID:38198777 | DOI:10.1159/000535752 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 10, 2024 Category: Urology & Nephrology Authors: Aurora P érez-Gómez Lucie Fernandez Joost P Schanstra Julie Klein Source Type: research
Association of serum activin levels with allograft outcomes in patients with kidney transplant: Results from the KNOW-KT
CONCLUSION: Post-transplant activin levels were independently associated with allograft functions as well as coronary artery calcification in kidney transplant patients.PMID:38198780 | DOI:10.1159/000536198 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - January 10, 2024 Category: Urology & Nephrology Authors: Hui-Yun Jung Jung-Hwa Ryu Myung-Gyu Kim Kyu Ha Huh Kyo Won Lee Hee-Yeon Jung Kyung Pyo Kang Han Ro Seungyeup Han Jaeseok Yang Source Type: research
