A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.
Authors: Yamamuro T, Inoue K, Nagai Y, Azuma D, Yamamoto A, Hara K, Kohara M, Iwata T, Nakatsuka S, Morii E, Yamamoto T Abstract Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical exami...
Source: Endocrine Journal - September 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Rescue of the fetal damage associated with high intrauterine pressure by 17 β-estradiol injection in ovariectomized progesterone-treated pregnant mice.
Rescue of the fetal damage associated with high intrauterine pressure by 17β-estradiol injection in ovariectomized progesterone-treated pregnant mice. Endocr J. 2018 Sep 19;: Authors: Tadotsu D, Kawate N, Tamada H Abstract The present study examined the effects of progesterone (P) and 17β-estradiol (E2) on fetal damage and intrauterine pressure in ovariectomized pregnant mice. The mice were ovariectomized on gestational day (GD) 9 (copulation plug = GD 0), and daily subcutaneous injection of various doses of P (2, 3 or 4 mg) or 4 mg P plus E2 (0.05 or 0.1 μg) was given thereafter. Although...
Source: Endocrine Journal - September 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Spontaneous virilization around puberty in NR5A1-related 46,XY sex reversal: additional case and a literature review.
Authors: Adachi M, Hasegawa T, Tanaka Y, Asakura Y, Hanakawa J, Muroya K Abstract A heterozygous NR5A1 mutation is one of the most frequent causes of 46,XY DSD (disorders of sex development). We here reported a NR5A1-related 46,XY DSD patient, who first received endocrinological attention at 10 years of age for clitoromegaly. The patient had been reared as a girl, and no signs of virilization had been detected before. On examination, her clitoris was 35 mm long and 10 mm wide, with Tanner 3° pubic hair. Urogenital sinus and labial fusion was absent, while her uterus was found to be severely hypoplastic. Her bas...
Source: Endocrine Journal - September 19, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of diet control on puberty onset and immunoreactivity of kisspeptin and neurokinin B in female rats.
We examined kisspeptin/Kiss1-receptor and neurokinin B/neurokinin3-receptor immunoreactivity (IR) in the arcuate nucleus of the pups. The onset of puberty in the high-fat group was significantly earlier than the control group. At the onset of puberty, the densities of kisspeptin and neurokinin B IR cells were significantly higher in the high-fat diet group than in the control group; however, the densities of KISS1 and neurokinin 3-receptor IR cells did not differ between the two groups. At PND 85, the density of kisspeptin and neurokinin B IR cells did not differ between control and high fat group. The density of densities...
Source: Endocrine Journal - September 19, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Utility of monoclonal PAX8 antibody for distinguishing intrathyroid thymic carcinoma from follicular cell-derived thyroid carcinoma.
Authors: Suzuki A, Hirokawa M, Takada N, Higuchi M, Tanaka A, Hayashi T, Kuma S, Miyauchi A Abstract Follicular cell-derived thyroid carcinomas, including thyroid squamous cell carcinomas (SCCs) and anaplastic carcinomas, are immunoreactive for paired-box gene 8 (PAX8), while non-follicular cell-derived thyroid carcinomas stain negative for the PAX8 antibody. Intrathyroid thymic carcinoma (ITTC) arising from the intrathyroidal ectopic thymus exhibits moderate-to-strong nuclear reactivity for polyclonal PAX8. This is difficult to understand given that PAX8 is not associated with embryonic thymic development. We aime...
Source: Endocrine Journal - September 15, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Vanishing of ruptured adrenal mass with takotsubo cardiomyopathy.
Authors: Takeshita Y, Teramura C, Takamura T Abstract A 45-year-old male suddenly experienced left-flank abdominal pain. Echocardiography revealed akinesis of the 'takotsubo cardiomyopathy' type. He experienced a sudden haemodynamic collapse (blood pressure, 324/154 mmHg; pulse rate, 180 beats/min) during emergency cardiac catheterisation. An abdominal computed tomography (CT) revealed expansion of a soft tissue mass 64 × 33 mm in dimension in the left adrenal region, with accumulation of fluid surrounding the left pararenal space. Three days after the attack, his urinary catecholamine concentrations were sli...
Source: Endocrine Journal - September 12, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Visceral adipose tissue increases shortly after the cessation of GH therapy in adults with Prader-Willi syndrome.
In conclusion, discontinuation of GH therapy caused rapid increases in visceral adipose tissue and LDL cholesterol levels. These findings indicate that continuation of GH therapy may be a therapeutic option to maintain body composition; however, further studies regarding the long-term benefits and adverse effects of GH therapy in adults with PWS are required. PMID: 30185718 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Pharmacokinetics of insulin disappearance after massive overdosing.
In conclusion, the t1/2 for insulin was elongated 2 to 7 times after massive overdosing, explaining why glucose supplementation is needed for long periods in these cases. PMID: 30185719 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Sex hormones play roles in determining musk composition during the early stages of musk secretion by musk deer (Moschus berezovskii).
In this study, we analyzed the dynamic changes in musk components from June to April of the following year. The result showed that musk morphological character, water content, total ion chromatographic pattern, and composition undergo seasonal change. Luminescence immunoassay and radioimmunoassay analyses were performed to determine corresponding fecal hormone levels. The results showed that testosterone, estrogen, and cortisol levels in feces change on a seasonal basis, and are significantly higher in June than in other months (p
Source: Endocrine Journal - September 5, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year's bone mineral density change.
In conclusion, thyroxine suppressive therapy in postmenopausal women had significant reduction in nodule volume at initial 2 years of treatment, especially in volume larger than 2.6 mL. Prolonged thyroxine treatment did not benefit nodular size reduction and may affect BMD minimally in postmenopausal women. PMID: 30158361 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Glucocorticoid resistance syndrome caused by a novel NR3C1 point mutation.
In conclusion, in patients with clinically unexpected ACTH-dependent hypercortisolemia, primary glucocorticoid resistance (GRS) should be considered. PMID: 30158362 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of anti-TNF therapy on thyroid function in patients with inflammatory bowel disease.
In conclusion, patients with IBD showed a quite high percentage of thyroid autoimmunity. After treatment with anti-TNF, FT4 levels were found to be reduced, while no changes in TSH, T3 levels and thyroid auto-antibodies were noted. PMID: 30135331 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Comment on: "Derivation of thyroid lymphoepithelial cysts from follicular cells".
Comment on: "Derivation of thyroid lymphoepithelial cysts from follicular cells". Endocr J. 2018 Aug 10;: Authors: Hirokawa M, Suzuki A, Miyauchi A PMID: 30101807 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Impact of preoperative pasireotide therapy on invasive octreotide-resistant acromegaly.
Authors: Yamamoto R, Robert Shima K, Igawa H, Kaikoi Y, Sasagawa Y, Hayashi Y, Inoshita N, Fukuoka H, Takahashi Y, Takamura T Abstract A 43-year-old woman with an 8-year history of diabetes, hypertension, and dyslipidemia presented with amenorrhea and convulsion. Her MRI scan revealed a 3.5-cm T2-hyperintense pituitary macroadenoma with suprasellar extension to the frontal lobe and bilateral cavernous sinus invasion. Her serum levels of GH and insulin-like growth factor-I (IGF-I) were elevated to 9.08 ng/mL (normal range:
Source: Endocrine Journal - August 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case of pheochromocytoma with a marked decrease in catecholamine levels after rupture in which a good outcome was achieved by elective surgery.
Authors: Murai N, Azami T, Iida T, Mikura K, Imai H, Kaji M, Hashizume M, Kigawa Y, Koizumi G, Tadokoro R, Endo K, Iizaka T, Saiki R, Otsuka F, Norose T, Yamagishi M, Kurokawa I, Oike N, Sasaki H, Nagasaka S Abstract Changes in imaging findings and hormone levels before and after pheochromocytoma rupture, as well as detailed histopathology of resected tumors, have rarely been reported. A 52-year-old woman developed hypertension and diabetes mellitus in 2014, but despite treatment with antihypertensive and hypoglycemic drugs, good control was not achieved. On April 2, 2016, the patient started to have headaches and ...
Source: Endocrine Journal - August 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Heterogeneous nature of diabetes in a family with a gain-of-function mutation in the ATP-binding cassette subfamily C member 8 (ABCC8) gene.
Authors: Shima KR, Usuda R, Futatani T, Akahori H, Kaneko S, Yorifuji T, Takamura T Abstract Gain-of-function ATP-binding cassette subfamily C member 8 (ABCC8) mutations are known to cause neonatal diabetes mellitus and maturity-onset diabetes in the young. However, the intrafamilial heterogeneous nature of diabetes caused by the ABCC8 mutation is not fully understood to date. To clarify the intrafamilial heterogeneous nature of monogenetic diabetes, we conducted a case study on a family with ABCC8 mutations. We investigated eight family members, including a neonatal diabetes patient, based on metabolic features an...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Age-related change in thyroid-stimulating hormone: a cross-sectional study in healthy euthyroid population.
Authors: Chen J, Zhou W, Pan F, Cui W, Li M, Hu Y Abstract This cross-sectional study aimed to examine changes in thyroid-stimulating hormone (TSH) concentration over age in China and investigate relationship between TSH and risk factors for cardiovascular disease (CVD) among euthyroid subjects. TSH, free triiodothyronine (FT3), free thyroxine (FT4), blood lipid, and glucose were measured. 7,693 individuals were subdivided into different age groups. Associations between TSH and CVD risk factors [age, body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), triglycerides, low density lip...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Clinical relevance of low androgen to gastroesophageal reflux symptoms.
Authors: Harada K, Hanayama Y, Yasuda M, Hasegawa K, Obika M, Kataoka H, Itoshima K, Okada K, Otsuka F Abstract The aim of this study was to determine the relationships between free testosterone (FT) level and parameters including laboratory data and data from questionnaires and to determine symptoms leading to the detection of late onset hypogonadism (LOH). We retrospectively reviewed medical records of patients in whom serum FT was measured in our hospital. Aging Male Symptoms (AMS) score, self-rating depression scale (SDS) and frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) score were ...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Unexpected high plasma xanthine oxidoreductase activity in female subjects with low levels of uric acid.
In conclusion, unexpected high plasma XOR activities were found in some female subjects with relatively low levels of uric acid. Measurement of plasma XOR activity may help to identify hypouricemic patients with a high risk for EIAKI. PMID: 30068899 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effectiveness of dapagliflozin for sleep-disordered breathing among Japanese patients with obesity and type 2 diabetes mellitus.
In conclusion, dapagliflozin might improve moderate to severe SDB but not mild SDB in Japanese patients with obesity and type 2 diabetes mellitus. PMID: 30047511 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 1, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.
Authors: Botelho IMB, Moura Neto A, Silva CA, Tambascia MA, Alegre SM, Zantut-Wittmann DE Abstract Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytok...
Source: Endocrine Journal - August 1, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Factors associated with treatment satisfaction in patients with type 2 diabetes mellitus using oral glucose-lowering agents: a cross-sectional study in urban districts in Japan.
Authors: Hayashi I, Watanabe N, Nakata S, Komatsu R, Motoda S, Fujita Y, Ishibashi C, Yamaguchi Baden M, Kimura T, Takahara M, Kozawa J, Imagawa A, Iwahashi H, Shimomura I Abstract Various oral glucose-lowering agents are available in Japan. Although the objective characteristics of these drugs are well described, little is known about treatment satisfaction by patients using these agents. The aim of this study was to assess treatment satisfaction of diabetic patients visiting diabetes clinics using the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and to determine the association of the DTSQ scores with var...
Source: Endocrine Journal - July 25, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Targeted next-generation sequencing of thirteen causative genes in Chinese patients with congenital hypothyroidism.
Authors: Long W, Lu G, Zhou W, Yang Y, Zhang B, Zhou H, Jiang L, Yu B Abstract To identify the spectrum and prevalence of thirteen causative genes mutations in congenital hypothyroidism (CH) patients, we collected blood samples and extracted genomic DNA of 106 CH patients, and designed a customized targeted next-generation sequencing panel containing 13 CH-causing genes to detect mutations. A total of 132 mutations were identified in 65.09% of patients (69/106) on the following nine genes: DUOX2, TG, TPO, TSHR, TTF1, TTF2, NKX2-5, PAX8 and GNAS. 69.70% (92/132) mutations related to thyroid dyshormonogenesis genes, ...
Source: Endocrine Journal - July 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

11-oxygenated C19 steroids as circulating androgens in women with polycystic ovary syndrome.
Authors: Yoshida T, Matsuzaki T, Miyado M, Saito K, Iwasa T, Matsubara Y, Ogata T, Irahara M, Fukami M Abstract 11-oxygenated C19 steroids (11oxC19s) are newly specified human androgens. Although median serum levels of 11oxC19 were reported to be higher in patients with polycystic ovary syndrome (PCOS) than in unaffected women, inter-individual variations in androgen levels among PCOS patients have poorly been investigated. Here, we quantified four 11oxC19s, i.e., 11-ketotestosterone (11KT), 11β-hydroxytestosterone (11OHT), 11β-hydroxyandrostenedione (11OHΔ4A), and 11-ketoandrostenedione (11KΔ...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Neutrophil-lymphocyte ratio correlates with limited joint mobility of hand in patients with type 2 diabetes.
Authors: Mineoka Y, Ishii M, Hashimoto Y, Nakamura N, Katsumi Y, Isono M, Fukui M Abstract Limited joint mobility (LJM) of hand, which is one of the complications of diabetic hand, is associated with diabetic micro- and macroangiopathy although the precise pathogenesis is not completely understood. Neutrophil-lymphocyte ratio (NLR), a simple and novel inflammatory marker, has been reported to have a predictive effect to some diabetic complications in recent years. However, it is not elucidated about the relationship between LJM of hand and NLR in patients with type 2 diabetes. We evaluated the relationships between...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of surgical treatment for acromegaly on knee MRI structural features.
This study was undertaken to analyze the effects of transsphenoidal surgery (TSS) on acromegalic arthropathy and elucidate whether knee MRI findings are reversible or irreversible. We analyzed 22 patients with acromegaly (63.7% females, median age 58 years) by knee MRI at diagnosis. Out of these 22 patients, 16 who underwent TSS (68.9% female, median age 58 years) were also subjected to knee MRI 2 months after TSS. As for X-ray undetectable findings, MRI detected synovial thickening, bone marrow lesion, ligament injury and meniscus injury in 22.7%, 22.7%, 4.7% and 59.1% of the patients, respectively. With respect to the 16...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Ethylenecarbodiimide-fixed splenocytes carrying whole islet antigens decrease the incidence of diabetes in NOD mice via down-regulation of effector memory T cells and autoantibodies.
In conclusion, ECDI-fixed splenocytes carrying whole islet antigens effectively prevented the onset of T1DM in NOD mice, via suppressing the production of autoantibodies and inducing anergy of autoreactive T cells. PMID: 29998909 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - July 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Regulation of compensatory β-cell proliferation by inter-organ networks from the liver to pancreatic β-cells.
Regulation of compensatory β-cell proliferation by inter-organ networks from the liver to pancreatic β-cells. Endocr J. 2018 Jul 03;: Authors: Imai J Abstract In insulin-resistant states such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. However, the mechanism(s) by which obesity induces compensatory β-cell responses is not fully understood. Recently, several studies have shown that signals from the liver, such as neuronal signals or humoral factors, regulate β-cell proliferation during obesity development. We previously reported a liver-brain-...
Source: Endocrine Journal - July 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas.
Authors: Kageyama K, Sakihara S, Kameda W, Sugiyama A, Takayasu S, Terui K, Daimon M Abstract Thyrotropin (TSH)-producing adenomas are a rare cause of hyperthyroidism and are a type of functional pituitary adenoma. The diagnosis of TSH-producing adenoma is a challenging problem in clinical endocrinology. Since growth hormone-releasing peptide-2 (GHRP-2) fails to induce TSH secretion in normal subjects, the effect of GHRP-2 on TSH levels was therefore examined in patients with TSH-producing adenomas. A total of 5 patients (4 women and 1 man) referred to our departments for further evaluation of pituitary hormones we...
Source: Endocrine Journal - July 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Cortisol cut-points for the glucagon stimulation test in the evaluation of hypothalamic pituitary adrenal axis.
Authors: Taieb A, Yosra H, Jihen M, Abdelkarim Asma B, Maha K, Molka C, Rouatbi S, Monia Z, Koussay A Abstract Diagnosis of adrenal insufficiency requires evaluation by dynamic stimulation tests. The insulin tolerance test (ITT) is accepted as the gold-standard test for the evaluation of hypothalamo-pituitary-adrenal (HPA) axis but the test is unpleasant and dangerous. Although it takes more time, glucagon stimulation test (GST) is a good alternative to ITT. The primary aim of this study was to compare the ITT and GSTs in the evaluation of HPA axe in patients with pituitary disorders. We conducted a prospective stu...
Source: Endocrine Journal - June 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The association between birth weight and the risk of type 2 diabetes mellitus: a systematic review and meta-analysis.
Authors: Zhao H, Song A, Zhang Y, Zhen Y, Song G, Ma H Abstract Previous studies have shown a relationship between type 2 diabetes mellitus and birth weight. We performed this meta-analysis to resolve the problem of inconsistent results. We conducted a literature search of PubMed, Embase and the Cochrane Library using "Diabetes Mellitus, Type 2," "Birth Weight," and some related free words. Twenty-one studies were included in accordance with inclusion and exclusion criteria, involving a total of 313,165 participants and 22,341 type 2 diabetes mellitus cases. A modified version of the Newcastle-O...
Source: Endocrine Journal - June 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Enduring remission of active and sight-threatening Graves' orbitopathy with rituximab: report of two cases.
Authors: Adamidou F, Anagnostis P, Boboridis K, Manani C, Georgiou T, Veneti S, Kita M Abstract Intravenous (i.v.) glucocorticosteroids (GCs) constitute the first-line treatment for active and moderate-to-severe Graves' orbitopathy (GO). In cases of persistent disease, rituximab, a monoclonal anti-CD20 antibody, may be used, although studies have yielded conflicting results. In case 1, a 50-year-old female heavy smoker presented with severe bilateral disfiguring eyelid edema of four months, bilateral exophthalmos and a clinical activity score (CAS) of 5/7. Laboratory investigation showed thyrotoxicosis and high thy...
Source: Endocrine Journal - June 27, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011-2012.
Authors: Kwak SY, Yongjoo Park C, Jo G, Yoen Kim O, Shin MJ Abstract Vitamin D deficiency affects>60% of the Korean population. Recent reports in Caucasian, African American, and Chinese populations indicate an association between vitamin D status and related single nucleotide polymorphisms (SNPs), but specific associations differ among study populations. We investigated the relationship between five SNPs involved in the vitamin D metabolic pathway (DHCR7 rs12785878, GC rs2282679, CYP2R1 rs12794714, CYP2R1 rs10741657, and CYP24A1 rs6013897) and serum 25-hydroxyvitamin D [25(OH)D] status in Koreans using the Kore...
Source: Endocrine Journal - June 27, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

TSH ratio as a novel diagnostic method for Cushing's syndrome.
Authors: Tamada D, Kitamura T, Takahara M, Tanaka T, Takeda M, Otsuki M, Shimomura I Abstract Circadian variations impact thyrotropin (TSH) secretion; in Cushing's syndrome (CS) patients, the nocturnal serum TSH surge is abolished. The aim of this prospective study is to examine whether serum TSH surge may be a useful diagnostic method for CS. This prospective study recruited 136 inpatients for differential diagnosis of CS or subclinical CS (SCS), and 21 inpatients with depression at Osaka University Hospital. Serum TSH surge was assessed by the midnight-to-morning serum TSH ratio (2300-2400 h to 0800-0900 h). The ...
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of lipoprotein-associated phospholipase A2 inhibitor on insulin resistance in streptozotocin-induced diabetic pregnant rats.
Authors: Wang GH, Jin J, Sun LZ Abstract This paper aims to investigate the influence of lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, darapladib, on insulin resistance (IR) in streptozotocin (STZ)-induced diabetic pregnant rats. The rat models were divided into Control (normal pregnancy), STZ + saline (STZ-induced diabetic pregnant rats), STZ + Low-dose and STZ + High-dose darapladib (STZ-induced diabetic pregnant rats treated with low-/high-dose darapladib) groups. Pathological changes were observed by Hematoxylin-eosin (HE) and Immunohistochemistry staining. Lp-PLA2 levels were determined by enzym...
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

False-positive TSH receptor antibody results in an infant with activating TSHR mutation.
Authors: Wong FC, Au EY, Ip RW, Yau HC, Lit LC PMID: 29925745 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Postoperative growth hormone dynamics in clinically nonfunctioning pituitary adenoma.
In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion. We also investigated how several factors affected GH dynamics. Of 119 patients analyzed, 94 (79.0%) had peak GH levels less than 9.0 ng/mL and were diagnosed with severe GHD (sGHD) immediately after surgery. Of those patients, 27 (28.7%) recovered from sGHD within 1-2 years after surgery. Univariate analyses confirmed that sGHD recovery improved significantly in patients that were younger, had only undergone a single primary surgery, had n...
Source: Endocrine Journal - June 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of total testosterone, free testosterone, bioavailable testosterone and sex hormone-binding globulin with hepatic steatosis and the ratio of aspartate aminotransferase to alanine aminotransferase.
In conclusion, higher TT and SHBG levels in men are associated with the reduced risk of hepatic steatosis and elevated AST/ALT ratios, independent of age, smoking, alcohol consumption and physical activity. PMID: 29910248 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the  expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.
Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway. Endocr J. 2018 Jun 09;: Authors: Lin YC, Chiu CH, Liu HC, Wang JY Abstract Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our enzyme immunoassay results showed that cu...
Source: Endocrine Journal - June 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI).
Authors: Babinska A, Kaszubowski M, Sworczak K Abstract Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor &...
Source: Endocrine Journal - June 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Caveolin-1 regulates autophagy activity in thyroid follicular cells and is involved in Hashimoto's thyroiditis disease.
In this study, we examined Th1 cytokines and Cav-1 expression in HT thyroid tissues, determined the effects of interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ) on Cav-1 and autophagy activity in TFC, and investigated the association between Cav-1 and autophagy activity in vitro. Our results indicate that higher levels of IL-1β and IFN-γ and lower levels of Cav-1 were expressed in thyroid tissues of HT patients than in those of normal controls. Cav-1 mRNA and protein levels were significantly decreased in TFC exposed to IL-1β and IFN-γ, accompanied by decreased expression of autophagy-...
Source: Endocrine Journal - June 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases.
In conclusion, the CRTH2 rs545659 and rs634681 SNPs were associated with the severity of HD, and the TARC/CCL17 rs223828 SNP was associated with the intractability of GD. PMID: 29848886 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Improved cardiometabolic risk factors in Japanese patients with type 2 diabetes treated with ipragliflozin: a pooled analysis of six randomized, placebo-controlled trials.
Authors: Kashiwagi A, Sakatani T, Nakamura I, Akiyama N, Kazuta K, Ueyama E, Takahashi H, Kosakai Y Abstract To examine differential improvements among cardiovascular risk factors in response to treatment with ipragliflozin in Japanese type 2 diabetes mellitus (T2DM) patients, we conducted a pooled analysis of six randomized, double-blind trials of Japanese T2DM patients who received ipragliflozin 50 mg/day or placebo and had patient-level data for cardiometabolic risk parameters. Risk factors included glycated hemoglobin (HbA1c), body weight, homeostatic model assessment for insulin resistance and beta-cell functi...
Source: Endocrine Journal - June 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Transducin β-like 1, X-linked and nuclear receptor co-‍repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors.
Transducin β-like 1, X-linked and nuclear receptor co-‍repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors. Endocr J. 2018 May 23;: Authors: Takamizawa T, Satoh T, Miyamoto T, Nakajima Y, Ishizuka T, Tomaru T, Yoshino S, Katano-Toki A, Nishikido A, Sapkota S, Watanabe T, Okamura T, Ishida E, Horiguchi K, Matsumoto S, Ishii S, Ozawa A, Shibusawa N, Okada S, Yamada M Abstract Mutations in TBL1X, a component of the nuclear receptor co-repressor (N-CoR) and silencing mediator of retinoic acid and thyroid hormone recept...
Source: Endocrine Journal - May 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the  Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.
Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes. Endocr J. 2018 May 22;: Authors: Shiga K, Urakami T, Suzuki J, Igarashi Y, Tajima H, Amemiya S, Sugihara S, Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) Abstract Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1...
Source: Endocrine Journal - May 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The relationship between vitronectin and hepatic insulin resistance in type 2 diabetes mellitus.
In this study, we aimed to compare the plasma vitronectin (VN) levels between patients with T2DM and insulin resistance (IR) and healthy controls. Seventy patients with IR and 70 age- and body mass index (BMI)-matched healthy controls were included in the study. The insulin, Waist-to-Hip Ratio (WHR), C-peptide (CP) and VN levels of all participants were examined. The homeostasis model of assessment for insulin resistence index (HOMA-IR (CP)) formula was used to calculate insulin resistance. The levels of BMI, fasting plasma gluose (FPG), 2-hour postprandial glucose (2hPG), glycated hemoglobins (HbA1c), and HOMA-IR (CP) wer...
Source: Endocrine Journal - May 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Metyrapone-responsive ectopic ACTH-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism.
Authors: Inoue M, Okamura K, Kitaoka C, Kinoshita F, Namitome R, Nakamura U, Shiota M, Goto K, Ohtsubo T, Matsumura K, Oda Y, Eto M, Kitazono T Abstract In ectopic ACTH-secreting pheochromocytoma, combined ACTH-driven hypercortisolemia and hyper-catecholaminemia are serious conditions, which can be fatal if not diagnosed and managed appropriately, especially when glucocorticoid-driven positive feedback is suggested with a high ACTH/cortisol ratio. A 46-year-old man presented with headache, rapid weight loss, hyperhidrosis, severe hypertension and hyperglycemia without typical Cushingoid appearance. Endocrinological...
Source: Endocrine Journal - May 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Identification of urinary biomarkers for the prediction of gestational diabetes mellitus in early second trimester of young gravidae based on iTRAQ quantitative proteomics.
Authors: Guo Y, Han Z, Guo L, Liu Y, Li G, Li H, Zhang J, Bai L, Wu H, Chen B Abstract Gestational Diabetes Mellitus (GDM) has brought great harm to maternal and fetus. Up to now, only a few plasma biomarkers for its early diagnosis have been reported; nevertheless, there is no report about identification of urinary biomarkers for prediction of GDM. Thus, it is necessary to correct this deficiency. In our study, urine samples were collected from 889 healthy young gravidae at the early second trimester (15 to 20 weeks), 69 of whom were subsequently diagnosed with GDM at 24 to 28 weeks. iTRAQ (the isobaric tags for r...
Source: Endocrine Journal - May 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Hydrogen sulfide ameliorates rat myocardial fibrosis induced by thyroxine through PI3K/AKT signaling pathway.
This study aims to investigate the role and regulatory mechanism of the Hydrogen sulfide (H2S) in amelioration of rat myocardial fibrosis induced by thyroxine through interfering the autophagy via regulating the activity of PI3K/AKT1 signaling pathway and the expression of relative miRNA. 40 adult male SD rats were randomly divided into 4 groups (n = 10): the control group, the thyroxine model group (TH group), the model group with H2S intervention (TH + H2S group) and the normal group with H2S intervention (H2S group). Pathological changes were observed via H&E staining and Masson staining, Expressions of MMPs/TIMPs, ...
Source: Endocrine Journal - May 12, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Angiotensin II aggravates lipopolysaccharide induced human pulmonary microvascular endothelial cells permeability in high glucose status.
This study suggests that in a diabetic infectious lung injury cellular model, AngII could aggravate the permeability of HPMVEC via F-actin dynamics and cell apoptosis. Furthermore, blocking the Angiotension II Type 1 Receptor could significantly alleviate the hyperpermeability of HPMVECs. PMID: 29709898 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - May 2, 2018 Category: Endocrinology Tags: Endocr J Source Type: research