Gene polymorphisms of VEGF and VEGFR2 are associated with the severity of Hashimoto's disease and the intractability of Graves' disease, respectively.
In conclusion, VEGF polymorphisms with lower activity were associated with the severity of HD, while VEGFR2 polymorphisms and the combinations of VEGF and VEGFR2 polymorphisms, which have stronger interactions, were associated with the intractability of GD. VEGF and VEGFR2 polymorphisms were associated with HD severity and GD intractability, respectively. PMID: 32074519 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 21, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Papillary thyroid carcinomas are highly obscured by inflammatory hypoechoic regions caused by subacute thyroiditis: a longitudinal evaluation of 710 patients using ultrasonography.
The objective of the study was to assess the diagnostic accuracy of ultrasonography in detecting nodular lesions in patients with subacute thyroiditis. We conducted a longitudinal study involving 710 patients with subacute thyroiditis who underwent ultrasonographic examinations in a single center between 2008 and 2018. These examinations were performed at initial diagnosis and during follow-up, with subsequent evaluation of nodules using fine needle aspiration cytology. Ultrasonographic examination used for the initial screening of thyroid nodules in patients with subacute thyroiditis showed a sensitivity of 72.4%, specifi...
Source: Endocrine Journal - February 20, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Diagnosis and treatment of autoimmune and IgG4-related hypophysitis: clinical guidelines of the Japan Endocrine Society.
Authors: Takagi H, Iwama S, Sugimura Y, Takahashi Y, Oki Y, Akamizu T, Arima H Abstract Hypophysitis, which is often accompanied by pituitary dysfunction, is classified into several subtypes based on the cause, histology, and the location of inflammation in the pituitary gland. A definitive diagnosis requires pituitary biopsy, which is invasive, and the process is limited to specialized clinical settings. In this opinion paper, we review the literature associated with hypophysitis, and provide the guidelines of the Japan Endocrine Society for the diagnosis and treatment of autoimmune and IgG4-related hypophysitis. ...
Source: Endocrine Journal - February 11, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Evaluation of the relationship between glycated hemoglobin A1c and mean glucose levels derived from the professional continuous flash glucose monitoring system.
Authors: Yamada M, Okada S, Oda H, Nakajima Y, C Bastie C, Kasai Y, Osaki A, Shimoda Y, Shibusawa R, Uehara R, Saito T, Ozawa A, Yamada E Abstract Previously, we reported that short-term continuous glucose monitoring (CGM) with the professional iPro2© CGM device is a good clinical indicator of glycated hemoglobin (HbA1c) levels. However, there was no significant correlation between CGM and HbA1c levels when HbA1c levels were>8.0%. To further investigate this issue, we performed a similar study using the FreeStyle Libre Pro©, a newer device that does not require glucose calibration and allows patients t...
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of long-term insulin pump treatment in patients with type 1 diabetes aged over 50 years.
Authors: Matejko B, Krzyżowska S, Kieć-Wilk B, Malecki MT, Klupa T Abstract Continuous subcutaneous insulin infusion (CSII) therapy using insulin pumps has become widely used in the treatment of type 1 diabetes mellitus (T1DM). This retrospective study aimed to assess the efficacy and safety of long-term insulin pump treatment in patients with T1DM aged ≥50 years. The study included patients aged ≥50 years, who had a diagnosis of T1DM based on clinical criteria and/or presence of autoantibodies characteristic of autoimmune diabetes, and had received ≥5 years of recent and uninterrupted treatment with a p...
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Association of diabetic nephropathy with the severity of obstructive sleep apnea-hypopnea syndrome in patients with type 2 diabetes mellitus.
This study aimed to analyze the effect of the severity of obstructive sleep apnea-hypopnea syndrome (OSAHS) on diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). A total of 322 patients with T2DM participated in this cross-sectional study. OSAHS was diagnosed according to the apnea-hypopnea index (AHI) and it was categorized as follows: normal, mild, moderate, and severe. Relevant clinical data retrieved from medical charts were cross-analyzed between different groups. The relationship between urinary albumin/creatinine ratio(UACR) and OSAHS parameters, which included AHI, lowest oxygen saturation ...
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Usefulness of the index calculated as the product of levels of fasting plasma glucose and hemoglobin A1c for insulinoma screening.
Authors: Torimoto K, Okada Y, Tanaka Y, Matsuoka A, Hirota Y, Ogawa W, Saisho Y, Kurihara I, Itoh H, Inada S, Koga M Abstract Hypoglycemia is the major symptom of insulinoma. Chronic and recurrent hypoglycemia leads to the disappearance of autonomic symptoms and persistence of non-specific symptoms alone, possibly contributing to the delayed diagnosis of insulinoma and accounting for several undiagnosed cases. We previously reported the usefulness of hemoglobin A1c (HbA1c) and glycated albumin as markers for early insulinoma screening; however, their diagnostic prediction performance and diagnostic performance were...
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Relation between HOMA-IR and insulin sensitivity index determined by hyperinsulinemic-euglycemic clamp analysis during treatment with a sodium-glucose cotransporter 2 inhibitor.
In conclusion, HOMA-IR was well correlated with ISI during SGLT2i treatment, but values corresponding to the same ISI were lower in the SGLT2i group than in the control group. PMID: 32023587 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Assessment of factors that determine the mean absolute relative difference in flash glucose monitoring with reference to plasma glucose levels in Japanese subjects without diabetes.
Authors: Yoshino S, Yamada E, Okada S, Nakajima Y, Shibusawa R, Uehara R, Matsumoto S, Horiguchi K, Ishida E, Saito T, Yamada M Abstract The Abbott FreeStyle Libre flash glucose monitoring system (FGM) is a recently introduced, but widespread continuous glucose monitoring system. While its mean absolute relative difference (MARD) value indicating its accuracy is acceptable with reference to the self-monitoring of blood glucose (SMBG) levels, few reports have examined the MARD in sensor glucose values of FGM (FGM-SG) with reference to plasma glucose (PG) levels and the factors determining it. We performed oral gluco...
Source: Endocrine Journal - February 7, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Reduced pubertal growth in children with obesity regardless of pubertal timing.
Authors: Yoshii K, Isojima T, Piedvache A, Morisaki N, Tanaka T, Nagata S Abstract Childhood obesity affects both pubertal growth and pubertal timing. We evaluated pubertal timing-mediated effects of childhood obesity on pubertal growth. This retrospective, representative-population-based cohort study included 6,733 boys and 6,916 girls born between April 1975 and March 1976 in Akita Prefecture, Japan. Individual changes in height standard deviation score between 7 and 17 years (ΔHtSDS), body mass index Z-score at 7 years (BMIZ), and estimated age at peak height velocity (ÂPHV) were used as surrogate in...
Source: Endocrine Journal - February 5, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice.
In this study, the mice fed high-fat high sucrose diet (HFHSD) containing a DPP4 inhibitor, anagliptin, showed reduced food intake and body weight compared to the mice fed non-treated HFHSD, but oxygen consumption and respiratory exchange ratio (RER) were not altered. Sequential administration of leptin suppressed food intake and body weight more apparently in anagliptin treated HFHSD fed mice than non-treated HFHSD fed mice. Oxygen consumption and RER were comparable between anagliptin treated and non-treated mice after leptin administration. The number of phospho STAT3 expressed cells in the arcuate nucleus after leptin ...
Source: Endocrine Journal - February 5, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Analysis of the effect of liraglutide on glycemic variability in patients with type 2 diabetes.
Authors: Xing Y, Chen J, Zhao L, Ma H Abstract The efficacy of liraglutide in the treatment of glycemic variability in type 2 diabetic patients remains to be fully elucidated. Some studies evaluated the efficacy and safety of liraglutide in glycemic variability, and this meta-analysis was performed to evaluate the accuracy of the results of existing studies on the efficacy of liraglutide. We conducted a comprehensive search for all relevant studies published in PubMed, EMBASE, Cochrane Library, and China Academic Journal Full-Text Database from the beginning of 2011 to October 31, 2019. The mean ± SD and 95%...
Source: Endocrine Journal - February 1, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Solid variant of papillary thyroid carcinoma: an under-recognized entity.
Authors: Ohashi R Abstract Solid variant of papillary thyroid carcinoma (SVPTC) is a rare morphological variant of papillary thyroid carcinoma (PTC). SVPTC is histologically characterized by predominant solid, trabecular and insular nests of tumor cells while cytological features of PTC such as nuclear grooves and nuclear inclusions are preserved. In fine needle aspiration cytology smears, tumor cells of SVPTC may be presented in cohesive, syncytial or trabecular clusters accompanied by some discohesiveness in the absence of necrosis. Although SVPTC and poorly differentiated thyroid carcinoma (PDTC) share similar h...
Source: Endocrine Journal - January 29, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Overestimation of glomerular filtration rate calculated from serum creatinine as compared with cystatin C in patients with subclinical hypercortisolism: Hyogo Adrenal Metabolic Registry.
Authors: Naka M, Kadoya M, Kosaka-Hamamoto K, Morimoto A, Miyoshi A, Kakutani M, Shoji T, Koyama H Abstract The skeletal muscle mass are decreased in the patients with hypercortisolism. Glomerular filtration rate (eGFR) is not accurately evaluated by calculation from serum creatinine (eGFRcre) in these patients. However, it is not known whether it applies to patients with subclinical hypercortisolism. We investigated the dissociation between eGFRcre and eGFR calculated from cystatin C (eGFRcys) in patients with subclinical hypercortisolism and its association with the skeletal muscle mass. This cross-sectional stud...
Source: Endocrine Journal - January 25, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes.
Authors: Kawasaki M, Arata N, Sakamoto N, Osamura A, Sato S, Ogawa Y, Yasuhi I, Waguri M, Hiramatsu Y Abstract For women with gestational diabetes mellitus (GDM), the evaluation of glucose tolerance (GT) in the early postpartum period is universally recommended. Nevertheless, few studies have evaluated the risk factors for T2DM on the basis of GT data obtained during the early postpartum period. We aimed to identify the risk factors for type 2 diabetes mellitus (T2DM) by evaluating GT in the first 12 weeks postpartum (12wPP) in women with GDM and to categorize the risk using a combination of the principal risk fact...
Source: Endocrine Journal - January 25, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants.
In conclusion, a direct stimulatory effect of thyroid hormone on the secretion (or production) of BNP was confirmed even in a large number of health examination participants. PMID: 31956210 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - January 22, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Anti-oxidative and anti-adipogenic effects of caffeine in an in vitro model of Graves' orbitopathy.
In conclusion, caffeine decreased oxidative stress and adipogenesis in GO orbital fibroblasts in vitro. These findings may contribute to the development of new types of caffeine-containing pharmacological agents for use in the management of GO. PMID: 31941844 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - January 18, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats.
Authors: Ieda N, Assadullah, Minabe S, Ikegami K, Watanabe Y, Sugimoto Y, Sugimoto A, Kawai N, Ishii H, Inoue N, Uenoyama Y, Tsukamura H Abstract Accumulating evidence suggests that kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B and dynorphin, are involved in gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) pulse generation, while the anteroventral periventricular nucleus (AVPV) kisspeptin neurons are responsible for GnRH/LH surge generation. The present study aims to examine whether GnRH(1-5), a GnRH metabolite, regulates LH release via kisspeptin neurons. GnRH(1-5) was...
Source: Endocrine Journal - January 18, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Living alone is associated with visit-to-visit HbA1c variability in men but not in women in people with type 2 diabetes: KAMOGAWA-DM cohort study.
Authors: Sakai R, Hashimoto Y, Hamaguchi M, Ushigome E, Okamura T, Majima S, Asano M, Yamazaki M, Fukui M Abstract The purpose of this study was to evaluate the association between living alone and glycemic parameters, especially glycemic variability, in men and women with type 2 diabetes. Lifestyle factors, including living alone, were assessed by a questionnaire in this cross-sectional study. Average, standard deviation (SD), and coefficient of variation (CV) of HbA1c were calculated using the values of HbA1c, which were extracted from the medical record for 1 year. Eighteen percent of men (35/198) and 17% of wom...
Source: Endocrine Journal - January 15, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Circular RNA HIPK3 contributes to hyperglycemia and insulin homeostasis by sponging miR-192-5p and upregulating transcription factor forkhead box O1.
Authors: Cai H, Jiang Z, Yang X, Lin J, Cai Q, Li X Abstract It has been shown that circular RNAs, a class of non-coding RNA molecules, play an important role in the regulation of glucose and lipid homeostasis. In the present study, we sought to investigate the function of circular RNA HIPK3 (circHIPK3) in diabetes-associated metabolic disorders, including hyperglycemia and insulin resistance. Results show that oleate stimulated circHIPK3 increase, and that circHIPK3 enhanced the stimulatory effect of oleate on adipose deposition, triglyceride (TG) content, and cellular glucose content in HepG2 cells. MiR-192-5p wa...
Source: Endocrine Journal - December 26, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation.
Authors: Tanaka M Abstract Metabolic syndrome is a common metabolic disorder that involves multiple organs and is predominantly influenced by obesity, especially the accumulation of visceral fat. It is also known that macrophages that infiltrate obese adipose tissue play an important role in inflammation of the adipose tissue. Macrophage-inducible C-type lectin (Mincle), a new inflammatory regulator found in obese adipose tissue, is expressed in pro-inflammatory M1 macrophages in adipose tissue. In addition, Mincle is expressed in macrophages that form a crown-like structure, where dead or dying adipocytes are surr...
Source: Endocrine Journal - December 20, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells.
Authors: Kanda R, Miyagawa Y, Wada-Hiraike O, Hiraike H, Fukui S, Nagasaka K, Ryo E, Fujii T, Osuga Y, Ayabe T Abstract Rikkunshito, a traditional Japanese herbal medicine, improves appetite via activation of gastrointestinal hormone ghrelin pathway. The function of ghrelin is mediated by growth hormone secretagogue receptor (GHSR1a), and ghrelin has been known to possess diverse physiological functions including growth suppression of some cancer cells. Considering that increased ghrelin signaling by Rikkunshito could enhance sirtuin1 (SIRT1) activity in nervous system, we aimed to investigate the effect of Rikkuns...
Source: Endocrine Journal - December 18, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis.
Authors: Chen Z, Wang Y, Ding X, Zhang M, He M, Zhao Y, Hu S, Zhao F, Wang J, Xie B, Shi B Abstract Autoimmune thyroid disease (AITD) is characterized by a loss of self-tolerance to thyroid antigen. Tregs, whose proportions are controversial among CD4+ T cell from AITD patients (AITDs), are crucial in immune tolerance. Considering that drugs might affect Treg levels, we assumed that the differences originated from different treatment statuses. Thus, we performed a meta-analysis to explore proportions of Tregs in untreated and treated AITDs. PubMed, Embase and ISI Web of Knowledge were searched for relevant studies....
Source: Endocrine Journal - December 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Role of a new bioassay for thyroid-stimulating antibodies (aequorin TSAb) in Graves' ophthalmopathy.
Authors: Hiromatsu Y, Eguchi H, Matsuo Y, Kato T, Tani J, Watanabe S, Teshima Y, Araki N Abstract Graves' ophthalmopathy (GO) is characterized by an autoimmune reaction against thyrotropin (TSH) receptors and is diagnosed by TSH receptor antibody (TRAb). A novel assay for thyroid-stimulating antibody (TSAb) was recently introduced using a frozen Chinese hamster ovary cell line expressing TSH receptors, cyclic adenosine monophosphate (cAMP)-gated calcium channel, and aequorin (aequorin TSAb). The aim of this study was to evaluate the role of aequorin TSAb in GO. We studied 136 Japanese patients with GO (22 euthyroid...
Source: Endocrine Journal - December 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Increased dietary fatty acids determine the fatty-acid profiles of human pancreatic cancer cells and their carrier's plasma, pancreas and liver.
Authors: Qiu S, Wang F, Hu J, Yang Y, Li D, Tian W, Yuan X, Lv Y, Yu M Abstract Primary contents of dietary fat are three or four types of fatty acids, namely saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), n6-polyunsaturated fatty acid (n6PUFA) and, to less extent, n3-polyunsaturated fatty acid (n3PUFA). Previous studies suggest that increased SFA, MUFA, and n6PUFA in high fat diets (HFDs) stimulate the origination, growth, and liver metastasis of pancreatic cancer cells, whereas increased n3PUFA has the opposite effects. It is unclear whether the fatty acid-induced effects are based on changed fatt...
Source: Endocrine Journal - December 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney.
Authors: Suzuki S, Yokoyama A, Noro E, Aoki S, Shimizu K, Shimada H, Sugawara A Abstract Carbohydrate response element binding protein (ChREBP), a glucose responsive transcription factor, mainly regulates expression of genes involved in glucose metabolism and lipogenesis. Recently, ChREBP is speculated to be involved in the onset and progression of diabetic nephropathy (DN). However, there exists no report regarding the localization and function of ChREBP in the kidney. Therefore, we analyzed the localization of Chrebp mRNA expression in the wild type (WT) mice kidney using laser microdissection method, and observe...
Source: Endocrine Journal - December 10, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Diagnostic accuracy of selective arterial calcium injection test for localization of gastrinoma.
In conclusion, our data suggest the strongest gastrin response evoked by SACI indicates the definitive location in patients with gastrinomas. In contrast, SACI could not accurately locate multiple gastrin-secreting lesions due to poor specificity. PMID: 31813923 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - December 10, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Left-right differences in adrenal vein sampling for primary aldosteronism.
Authors: Miyoshi A, Wada N, Baba S, Obara S, Takahashi B, Usubuchi H, Terae S Abstract In adrenal venous sampling (AVS) for patients with primary aldosteronism (PA), adrenocorticotropic hormone (ACTH) stimulation generally increased the success rate. The effect of ACTH stimulation on the left-right differences of laterality diagnosis in AVS remains unclear. A total of 167 patients with PA underwent successful AVS were examined. Patients with autonomous cortisol secretion were excluded. The proportion of dominant side in AVS was compared before and after ACTH stimulation. Unilateral disease on AVS was defined as a l...
Source: Endocrine Journal - December 6, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Presence of aberrant adrenocorticotropic hormone precursors in two cases of McCune-Albright syndrome.
Authors: Takayasu S, Makita K, Kageyama K, Okawa Y, Oki Y, Yamagata S, Asari Y, Terui K, Daimon M Abstract McCune-Albright syndrome (MAS) is a rare disorder. MAS is classically defined by the occurrence of fibrous dysplasia, café-au-lait skin macules, and precocious puberty. In addition to precocious puberty, other hyperfunctioning endocrinopathies may occur. We evaluated hypothalamic-pituitary-adrenal function in two cases of typical MAS associated with fibrous dysplasia and growth hormone excess. Pituitary adenoma or hyperplasia was not detected by magnetic resonance imaging. Hormonal data showed normal or...
Source: Endocrine Journal - December 6, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Sentinel lymph node biopsy in medullary thyroid microcarcinomas.
Authors: Santrac N, Markovic I, Medic Milijic N, Goran M, Buta M, Djurisic I, Dzodic R Abstract The aim of this prospective study was to analyze accuracy of sentinel lymph node biopsy with methylene blue dye for intraoperative detection of lateral metastases in clinically N0M0 medullary microcarcinomas with calcitonin
Source: Endocrine Journal - December 6, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Authors: Ishii S, Yamada M, Koibuchi N Abstract The chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays essential roles in organogenesis of embryos. Recently COUP-TFII is also implicated in several diseases in adults. Here we focus on the role of COUP-TFII in cisplatin-induced acute kidney injury (AKI). COUP-TFII was the most abundantly expressed in the kidney among organs. Male tamoxifen-inducible COUP-TFII-knockout mice or control mice were intraperitoneally treated with 30 mg/kg body weight of cisplatin at 12 weeks old to induce AKI. The kidney samples were subject to morphological stud...
Source: Endocrine Journal - December 6, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Preoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas.
Authors: Soga A, Fukuda I, Kobayashi S, Tahara S, Morita A, Sugihara H Abstract Non-functioning pituitary adenoma (NFPA) is one common cause of adult growth hormone deficiency (AGHD). In Japan, a GH-releasing peptide (GHRP)-2 test is used to evaluate GH secretion. Although the cut-off for peak GH during a GHRP-2 test for severe AGHD is ≤9 ng/mL, severe AGHD may further diminish responses (range, nearly no-response to ≤9 ng/mL). We studied whether the peak GH responses during a GHRP-2 test could be predicted based on clinical characteristics of patients with NFPA. We compared patients with almost no-response d...
Source: Endocrine Journal - November 30, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Subset analysis of the Japanese risk classification guidelines for papillary thyroid carcinoma.
Authors: Ito Y, Miyauchi A, Yamamoto M, Masuoka H, Higashiyama T, Kihara M, Miya A Abstract Guidelines published by the Japan Association of Endocrine Surgeons (JAES)/Japanese Society of Thyroid Surgery (JSTS) for patients with papillary thyroid carcinoma describe four risk classes (very low-, low-, intermediate- and high-risk) for deciding on therapeutic strategies. Here, we investigate cause-specific survival (CSS) of high- and intermediate-risk patients, taking their age into consideration. CSS of intermediate-risk patients ≥55 years was poorer than that of those
Source: Endocrine Journal - November 30, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation.
Authors: Komatsu S, Nomiyama T, Numata T, Kawanami T, Hamaguchi Y, Iwaya C, Horikawa T, Fujimura-Tanaka Y, Hamanoue N, Motonaga R, Tanabe M, Inoue R, Yanase T, Kawanami D Abstract Cancer is currently one of the major causes of death in patients with type 2 diabetes mellitus. We previously reported the beneficial effects of the glucagon-like peptide-1 receptor agonist exendin-4 against prostate and breast cancer. In the present study, we examined the anti-cancer effect of the sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin using a breast cancer model. In human breast cancer MCF-7 cells, SGLT2 expressi...
Source: Endocrine Journal - November 30, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Factory-calibrated continuous glucose monitoring and capillary blood glucose monitoring in a case with insulinoma: usefulness and possible pitfall under chronic hyperinsulinemic hypoglycemia.
Authors: Suminaga K, Murakami T, Yabe D, Sone M, Sugawa T, Masui T, Uza N, Yoshizawa A, Ogura M, Yasoda A, Inagaki N Abstract The accuracy of factory-calibrated continuous glucose monitoring (fCGM) within hypoglycemic ranges, especially under the status of chronic hyperinsulinemic hypoglycemia like insulinomas, remains an issue. Even so, fCGM is known to be useful for detecting hypoglycemia unawareness in insulinoma cases. A 25-year-old woman presenting with sudden unconsciousness was diagnosed with insulinoma; fCGM facilitated diagnosis by continuous monitoring for hypoglycemia. Before surgery, she was treated wit...
Source: Endocrine Journal - November 26, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Association between circulating zinc- α2-glycoprotein levels and the different phenotypes of polycystic ovary syndrome.
Association between circulating zinc-α2-glycoprotein levels and the different phenotypes of polycystic ovary syndrome. Endocr J. 2019 Nov 21;: Authors: Tang C, Li X, Tang S, Wang Y, Tan X Abstract Polycystic ovary syndrome (PCOS) diagnosis combines various clinical phenotypes. The definition of PCOS is still controversial because insulin resistance (IR) and dysmetabolism do not constitute PCOS diagnostic criteria. We analyzed whether a circulating biomarker zinc-α2-glycoprotein (ZAG) related to IR and metabolic dysfunction can predict PCOS phenotypes. We then recruited 100 PCOS patients and...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion.
In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen control subjects, mostly with hypothalamo-pituitary disease but without CDI, and 13 patients with CDI were enrolled in the study. Whether or not subjects had CDI was determined based on the totality of clinical data, which included urine volumes and osmolality. Regression analysis of plasma AVP and serum Na concentrations revealed that the gradient was significantly lower in the CDI group than in the control group. The area under the receiver-operati...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver.
Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver. Endocr J. 2019 Nov 19;: Authors: Nakata T, Hirano Y, Katsumata H, Tokita R, Yagi T, Toyoshima Y, Minami S Abstract Growth hormone (GH) has multiple physiological roles, acting on many organs. In order to investigate its roles in rat liver, we tried to identify novel genes whose transcription was regulated by GH. We identified X-box binding protein 1 (Xbp1) as a candidate gene. XBP1 is a key transcription...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Morphological and functional changes in neonatally X- ‍irradiated thyroid gland in rats.
In conclusion, our results clearly demonstrated that neonatal rat thyroid was sensitive to ionized radiation, developing specific morphological changes characterized by smaller thyroid follicles along with changes in serum TSH levels and Tg expressions in the thyroid tissue. PMID: 31748432 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Identification of novel mutations of ovarian cancer-related genes from RNA-sequencing data for Japanese epithelial ovarian cancer patients.
Authors: Nagasawa S, Ikeda K, Horie-Inoue K, Sato S, Takeda S, Hasegawa K, Inoue S Abstract Ovarian cancer has the highest mortality rate among gynecological cancers. Gene mutations are involved in the carcinogenesis, metastasis, and therapeutic response in ovarian cancer. However, the variety and proportion of gene mutation is not fully analyzed in Japanese ovarian cancer patients, especially, in those with recurrent tumors. In the present study, RNA-sequencing was performed for 32 clinical ovarian specimens obtained from 24 Japanese patients (24 primary cancer specimens and 8 recurrent specimens paired with corre...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Urinary equol is associated with bioavailable testosterone but not total testosterone in women.
In this study, we examined the associations of urinary equol concentrations with serum concentrations of total, bioavailable and free testosterone (FT), dehydroepiandrosterone sulfide (DHEAS), free androgen index (FAI) and sex hormone-binding globulin (SHBG). This cross-sectional study included 1,904 women with a mean age of 59.7 years. Urinary equol concentrations were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The serum androgenic indices and SHBG were also determined. Overall, urinary equol tended to be inversely associated with bioactive forms of androgenic indices (BT,...
Source: Endocrine Journal - November 23, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Long-term safety and treatment outcomes of pegvisomant in Japanese patients with acromegaly: results from the post-marketing surveillance.
Authors: Yamaguchi H, Shimatsu A, Okayama A, Sato T Abstract This post-marketing surveillance is to investigate the long-term safety and effectiveness of the growth hormone receptor antagonist pegvisomant, which is used in patients with acromegaly in routine clinical practice. This surveillance included all cases treated with pegvisomant during the study period from the start of marketing (June 5, 2007) to December 2015. Data for 251 patients with acromegaly treated with pegvisomant were collected from 119 institutions nationwide in Japan. Eighty-five patients received pegvisomant monotherapy throughout their treat...
Source: Endocrine Journal - November 16, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Diagnostic values of thyroglobulin in lymph node fine-needle aspiration washout: a systematic review and meta-analysis diagnostic values of FNA-Tg.
Authors: Zhu XH, Zhou JN, Qian YY, Yang K, Wen QL, Zhang QH, Xia L, Ge MH, Sun CX Abstract Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) served as an important measurement for suspicious recurrent or metastatic lesions. We conducted a pooled analysis to evaluate the diagnostic accuracy of FNA-Tg and searched electronic databases for original articles in English from 1993 through 2017. Finally, a total of 22 studies containing 2,670 lymph nodes (LNs) that enrolled participants with suspicious neck LNs during thyroid nodule workup or papillary thyroid cancer (PTC) follow-up wer...
Source: Endocrine Journal - November 16, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles.
Authors: Fukaishi T, Minami I, Masuda S, Miyachi Y, Tsujimoto K, Izumiyama H, Hashimoto K, Yoshida M, Takahashi S, Kashimada K, Morio T, Kosaki K, Maezawa Y, Yokote K, Yoshimoto T, Yamada T Abstract We herein report a case of a 28-year-old man with generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement. He showed symptoms of generalized lipodystrophy around onset of puberty. His body mass index was 11.9 kg/m2, and he had a short stature, birdlike facies, dental crowding due to micrognathia, partial graying and loss of hair, and a high-pitched voice, all of which are typical features o...
Source: Endocrine Journal - November 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.
Authors: Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H Abstract Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted a clinical tria...
Source: Endocrine Journal - November 8, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Vocal cord paralysis due to ectopic parathyroid adenoma and function recovery: a case report and review of the literature.
Authors: Zhao T, Xin Y, Shen H, Liu X, Wang J, Wang Q, Wei B Abstract Ectopic parathyroid adenomas (PAs) can occur in numerous locations and are thought to be the cause of a significant portion of failed primary surgery for hyperparathyroidism. PA is a rare cause of hoarseness, which may be harbingers of a malignant process. Here, we describe an unusual case of an ectopic PA in the carotid sheath presenting as unilateral vocal cord paralysis (VCP). A 49-year-old lady presented with a 1-week history of hoarseness, irritating cough and shortness of breath. Fibreoptic laryngoscopy revealed left VCP. Ultrasound and com...
Source: Endocrine Journal - November 8, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality.
Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality. Endocr J. 2019 Nov 06;: Authors: Shirakawa J, Terauchi Y Abstract Insulin secretion by the pancreatic β-cells is elicited in response to elevated extracellular glucose concentration. In addition to triggering insulin secretion, glucose-induced signal regulates β-cell proliferation and survival. However, the molecular mechanism underlying the effects of glucose on the β-cell functionality still remains unclear. Glucokinase, a hexokinase isozyme that catalyzes the phosphorylation of glucose,...
Source: Endocrine Journal - November 8, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

A nationwide survey of adrenal incidentalomas in Japan: the first report of clinical and epidemiological features.
This study had been originally carried out as a project of a research proposed on behalf of the Japanese Ministry of Health, Labour and Welfare, from 1999 to 2004. This nationwide multicenter study on AIs included 3,672 cases with clinically diagnosed AIs, involving 1,874 males and 1,738 females, with mean age 58.1 ± 13.0 years (mean ± SD). In the present study, we focused on the investigation of the real prevalence of various adrenal disorders with AI. The mean nodule size of AI based on computed tomography was 3.0 ± 2.0 cm. Compared to non-functioning adenomas (NFAs), tumor diameters were significant...
Source: Endocrine Journal - November 8, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Ubiquitin-specific protease 8 inhibitor suppresses adrenocorticotropic hormone production and corticotroph tumor cell proliferation.
In this study, the effects of a potent USP8 inhibitor, DUBs-IN-2, on ACTH production and cell proliferation were examined in mouse corticotroph tumor (AtT-20) cells. Proopiomelanocortin (Pomc) mRNA levels and ACTH levels were decreased in AtT-20 cells by DUBs-IN-2. Further, cell proliferation was inhibited, and apoptosis was induced by DUBs-IN-2. Transcript levels of pituitary tumor-transforming gene 1 (Pttg1), a pituitary tumor growth marker, were increased; and transcript levels of stress response growth arrest and DNA damage-inducible 45 (Gadd45β) and Cdk5 and ABL enzyme substrate 1 (Cables1) mRNA levels were incre...
Source: Endocrine Journal - November 3, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital.
Authors: Shimazaki S, Kazukawa I, Mori K, Kihara M, Minagawa M Abstract We retrospectively analyzed endocrine late effects in 81 childhood cancer survivor (CCS) patients who had been referred to our endocrinology department in Chiba Children's Hospital between January 1, 2008 and December 31, 2016. Among 69 eligible patients (33 male, 36 female), endocrine late effects were identified in 56 patients (81.1%). The median age at the last visit to our endocrinology department was 17.4 years (range: 7.1-35.3 years). The most common primary cancer was acute lymphoblastic leukemia (22 patients, 31.8%). Forty-four patients...
Source: Endocrine Journal - October 29, 2019 Category: Endocrinology Tags: Endocr J Source Type: research