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Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes.
In conclusion, SGLT2i reduced not only HbA1c, BW and BMI but also AHI significantly and therefore has potential as an effective treatment of OSAS. PMID: 29459554 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Metabolic and immunological assessment of small-for-gestational-age children during one-year treatment with growth hormone: the clinical impact of apolipoproteins.
In conclusion, there was no evidence suggesting metabolic abnormalities in SGA children. Serum apolipoprotein changes might predict the beneficial role of GH treatment in lowering cardiometabolic risk. PMID: 29459555 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Concurrent variant type 3 autoimmune polyglandular syndrome and pulmonary arterial hypertension in a  Japanese woman.
We describe a very rare case of concurrent variant type 3 autoimmune polyglandular syndrome (APS) and pulmonary arterial hypertension (PAH). A previously healthy 65-year-old Japanese woman was referred to our university hospital with a 2-month history of general fatigue and hyperglycemia. Laboratory tests revealed severe hyperglycemia (plasma glucose 543 mg/dL and HbA1c 10.7%) with ketonuria (3+). Glutamic acid decarboxylase (GAD) and IA-2 antibodies were positive, and the serum C peptide level was markedly decreased to 0.2 ng/mL. Accordingly, type 1 diabetes was diagnosed. Hashimoto's thyroiditis was also diagnosed becaus...
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma.
Authors: Takenobu M, Moritani S, Yoshioka K, Morisaki T, Kitano H Abstract Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemoth...
Source: Endocrine Journal - February 17, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity.
Authors: Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi KS, Choo YS, Yoon D, Kim MO, Ryoo ZY Abstract Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a major role in angiogenesis and vasculogenesis. Previous study demonstrated that PlGF-overexpressing transgenic (Tg) mice had gestational loss. In addition, PlGF secretion was up-regulated in isolated T lymphocytes (T-cell) upon CD3/CD28 stimulation, suggesting that PlGF could be a regulator of T-cell differentiation and development. T-cells are well known to play a critical role in obe...
Source: Endocrine Journal - February 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Validation of simple indexes for nonalcoholic fatty liver disease in western China: a retrospective cross-sectional study.
This study was aimed to evaluate various indexes for NAFLD in western China. It was a retrospective cross-sectional study, using data from a large-scale health check-up project at Sichuan provincial hospital. Receiver operating characteristic (ROC) curves of eight indexes, including the fatty liver index (FLI), the hepatic steatosis index, lipid accumulation product and etc., were developed to predict ultrasonographic NAFLD. There were 13,122 subjects in this study (2,692 NAFLD patients and 10,430 non-NAFLD participants). The area under ROC curve of FLI for predicting NAFLD was 0.880 (95% confidence interval, 0.874-0.886),...
Source: Endocrine Journal - February 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type.
In conclusion, thyroid SMECE has favorable outcomes and seems to be genetically different from salivary MEC. This is the first report to describe the presence of increased IgG4-positive plasma cells in the stroma of SMECE. PMID: 29415898 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 10, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study.
We examined the differences in clinical and metabolic parameters between those who have late-night-dinner and those who do not have. We also examined the relationship between late-night-dinner and HbA1c, using multiple regression analysis. Ninety-five people (23.2%) had a late-night-dinner, among 409 people with type 2 diabetes. Metabolic parameters (mean (SD) or median (interquartile range)) of people with late-night-dinner were worse than those of without, including body mass index (BMI) (24.4 (4.0) vs. 23.2 (3.4) kg/m2, p = 0.006), triglycerides (1.5 (1.1-2.1) vs. 1.2 (0.8-1.7) mmol/L, p
Source: Endocrine Journal - January 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of sodium-glucose cotransporter 2 inhibitors as add-on to metformin and sulfonylurea treatment for the management of type 2 diabetes: a meta-analysis.
This study evaluates the efficacy and safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors as add-on to metformin and sulfonylurea treatment for type 2 diabetes management. The literature search was conducted in electronic databases and meta-analyses of mean differences in the changes from baseline in selected disease endpoints (efficacy endpoints) or odds ratios (for safety endpoints) were performed to compare outcomes between SGLT2 inhibitor- and placebo-/comparator-treatments. Seven studies (5,143 patients; age 56.75 years [95% CI: 56.19, 57.37]; body mass index 29.53 kg/m2 [28.23, 30.83]; and 51.87% [50.46, 53.5...
Source: Endocrine Journal - January 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The roles of kisspeptin and gonadotropin inhibitory hormone in stress-induced reproductive disorders.
Authors: Iwasa T, Matsuzaki T, Yano K, Mayila Y, Irahara M Abstract Several kinds of stress suppress the hypothalamic-pituitary-gonadal (HPG) axis and reproductive behavior in humans and animals. These changes can eventually cause diseases and disorders, such as amenorrhea and infertility. In previous studies, it has been shown that stress-related factors, e.g., corticotropin-releasing hormone, cortisol, and pro-inflammatory cytokines, promote the stress-induced suppression of the HPG axis. However, these mechanisms are not sufficient to explain how stress suppresses HPG axis activity, and it has been suggested tha...
Source: Endocrine Journal - January 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of linagliptin monotherapy compared with voglibose on postprandial lipid profiles in Japanese patients with type 2 diabetes: linagliptin study of effects on postprandial blood glucose (L-STEP) sub-study 1.
Authors: Kurozumi A, Okada Y, Satoh H, Inoue I, Chimori H, Akita E, Shiraiwa T, Fujitani Y, Mita T, Gosho M, Watada H Abstract Recently, we reported that linagliptin had equivalent efficacy to voglibose in reducing postprandial blood glucose levels in drug-naïve patients with type 2 diabetes (L-STEP Study). As a sub-study of the L-STEP Study we examined the effect of linagliptin on postprandial lipids profile. Between October 2012 and April 2014, the study enrolled patients with type 2 diabetes mellitus who had inadequate glycemic control. Patients were randomly assigned to either the linagliptin group (5 mg o...
Source: Endocrine Journal - January 27, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells.
Authors: Nakashima K, Takeuchi S, Iwama S, Kiyota A, Yasuda Y, Iwata N, Enomoto A, Arima H, Sugimura Y Abstract The molecular mechanism involved in the exocytosis of arginine vasopressin (AVP) is not fully known. Rabphilin-3A has been suggested as a novel autoantigen in infundibulo-neurohypophysitis (LINH), which leads to central diabetes insipidus through insufficient secretion of AVP. However, the role of rabphilin-3A in the pathogenesis of LINH remains unclear. Thus, the aim of the present study was to identify proteins binding rabphilin-3A in the posterior pituitary. Using glutathione S-transferase (GST)-pulldo...
Source: Endocrine Journal - January 27, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan.
Authors: Naruse M, Satoh F, Tanabe A, Okamoto T, Ichihara A, Tsuiki M, Katabami T, Nomura M, Tanaka T, Matsuda T, Imai T, Yamada M, Harada T, Kawata N, Takekoshi K Abstract To assess the efficacy, safety, and pharmacokinetics of metyrosine (an inhibitor of catecholamine synthesis) in patients with pheochromocytoma/paraganglioma (PPGL), we conducted a prospective, multi-center, open-label study at 11 sites in Japan. We recruited PPGL patients aged ≥12 years requiring preoperative or chronic treatment, receiving α-blocker treatment, having baseline urinary metanephrine (uMN) or normetanephrine (uNMN) levels ...
Source: Endocrine Journal - January 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis.
Authors: Shu X, Shu S, Tang S, Yang L, Liu D, Li K, Dong Z, Ma Z, Zhu Z, Din J Abstract Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. To assess the current evidence regarding the efficiency and potential advantages of stem cell-based therapy compared with conventional standard treatment and/or placebo in the tr...
Source: Endocrine Journal - January 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Determining patient selection tool and response predictor for outpatient 30 mCi radioiodine ablation dose in non-metastatic differentiated thyroid carcinoma: a Japanese perspective.
This study evaluated factors to find response predictor and determinant for the suitable patients. The retrospective study reviewed 47 eligible non-metastatic papillary DTC patients whose had first 30 mCi RAI ablation after total thyroidectomy. Age, gender, clinical stage, risk category, and pre-ablation serum thyroglobulin (Tg) level were among covariates analyzed to determine the patient selection factors; while the thyroid bed uptake on initial whole body scan (WBS) was later also included in determining RAI ablation response. Thirteen (28%) patients had a low risk (T1-2) while 23 (49%) and 11 (23%) had an intermediate ...
Source: Endocrine Journal - January 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients.
Authors: Arici M, Oztas E, Yanar F, Aksakal N, Ozcinar B, Ozhan G Abstract Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Generally, dose adjustment is made by trial and error approach. However,...
Source: Endocrine Journal - January 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases.
In conclusion, pediatric prolactinoma exhibits a broad clinical spectrum, a relatively high incidence of macroadenoma, resistance to medical therapy, and frequent tumor relapses. In addition, a poor prognosis appears to be correlated with male sex, age at disease onset, and histopathological characteristics. PMID: 29279457 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - December 29, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Whole-genome sequencing revealed armadillo repeat containing 5 (ARMC5) mutation in a Chinese family with ACTH-independent macronodular adrenal hyperplasia.
Authors: Zhang Q, Cui L, Gao JP, Yan WH, Jin N, Chen K, Zang L, Du J, Wang XL, Guo QH, Yang GQ, Yang LJ, Ba JM, Gu WJ, Lv ZH, Dou JT, Mu YM, Lu JM Abstract Primary macronodular adrenal hyperplasia (PMAH), also known in the past as bilateral macronodular adrenalhyperplasia or adrenocorticotropin (ACTH)-independent macronodular adrenal hyperplasia, is a rare type of Cushing's syndrome (CS) and is associated with bilateralenlargement of the adrenal glands. It accounts for
Source: Endocrine Journal - December 29, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Clinical factors related to the efficacy of tyrosine kinase inhibitor therapy in radioactive iodine refractory recurrent differentiated thyroid cancer patients.
Authors: Sugino K, Nagahama M, Kitagawa W, Ohkuwa K, Uruno T, Matsuzu K, Suzuki A, Masaki C, Akaishi J, Hames KY, Tomoda C, Ogimi Y, Ito K Abstract New insights in thyroid cancer biology propelled the development of targeted therapies as salvage treatment for radioiodine-refractory differentiated thyroid cancer (RR-DTC), and the tyrosine kinase inhibitor (TKI) lenvatinib has recently become available as a new line of therapy for RR-DTC. The aim of this study is to investigate clinical factors related to the efficacy of TKI therapy in recurrent RR-DTC patients and identify the optimal timing for the start of TKI the...
Source: Endocrine Journal - December 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts via Smad-independent mechanisms.
Authors: Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T Abstract Previous studies showed that adenosine monophosphate-activated protein kinase (AMPK), which plays as an intracellular energy sensor, promotes the differentiation and mineralization of osteoblasts via enhancing expression of bone morphogenetic protein (BMP)-2, which is a potent inducer of osteoblastogenesis. Thus, the aim of this study was to examine the roles of AMPK in BMP-2-induced osteoblastogenesis. We used a murine osteoblastic cell line MC3T3-E1 and a murine marrow stromal cell line ST2. BMP-2 (50 and 100 ng/mL) stimulated alkaline phospha...
Source: Endocrine Journal - December 19, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The relationships among hyperuricemia, body mass index and impaired renal function in type 2 diabetic patients.
This study was conceived to explore the possible mechanisms of how hyperuricemia and obesity contribute to renal function impairment in type 2 diabetic (T2DM) patients. A cross-sectional study in 609 participants recruited from a T2DM population in North China was conducted. The multiplicative interaction between body mass index (BMI) and uric acid (UA) level was assessed using an interaction term in a logistic regression analysis. Our results indicate that male T2DM patients having higher BMI (OR 1.711, p = 0.038), blood urine nitrogen (BUN) (OR 1.100, p = 0.034), and 24-hour urinary micro-albumin levels (OR 1.004, p = 0....
Source: Endocrine Journal - December 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Frailty in elderly diabetes patients.
Authors: Yanase T, Yanagita I, Muta K, Nawata H Abstract Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/fra...
Source: Endocrine Journal - December 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat.
Authors: Sun D, Zhou L, Wang S, Liu T, Zhu J, Jia Y, Xu J, Chen H, Wang Q, Xu F, Zhang Y, Ye L Abstract Di-(2-ethylhexyl) phthalate (DEHP) is extensively used in many personal care and consumer products, which has resulted in widespread human exposure. Limited studies have suggested that exposure to DEHP may affect thyroid function, but little is known about the effect and mechanisms of DEHP exposure on the hypothalamic-pituitary-thyroid axis (HPTA). The present study was conducted to elucidate the potential mechanisms in which DEHP disrupts the function of the HPTA. Wistar rats were administered DEHP by gavage at ...
Source: Endocrine Journal - December 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Prevalence of central fatness in 1992-1994: 40% of Japanese boys 6-17 years.
Authors: Inokuchi M, Matsuo N, I Takayama J, Hasegawa T Abstract Obesity in children is a serious public health problem in Japan. However, the prevalence of central fatness has not been well determined in Japanese youth. We studied the relationship between body mass index (BMI) and waist circumference (WC) using line of equality analysis in 5,787 boys and 4,639 girls aged 6 to 17 years who participated in the 1992-1994 national survey on body sizes. WC was measured at the level of maximum waist narrowing in girls (WC1) and at the level of the top of iliac crest in boys (WC2). Using the 1978-1981 national survey dat...
Source: Endocrine Journal - December 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Parathyroid carcinoma occurred in two glands in multiple endocrine neoplasia 1: a report on a rare case.
Authors: Omi Y, Horiuchi K, Haniu K, Tokura M, Nagai E, Isozaki O, Nagashima Y, Okamoto T Abstract Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, re...
Source: Endocrine Journal - December 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.
In this study, we present a "sporadic/isolated" Japanese woman who was ultimately diagnosed with mandibular hypoplasia, deafness, progeroid features, and progressive lipodystrophy (MDPL) syndrome (MIM #615381) using whole exome sequencing analysis. She had been suspected as having atypical Werner syndrome and/or progeroid syndrome based on observations spanning a 30-year period; however, repeated genetic testing by Sanger sequencing did not identify any causative mutation related to various subtypes of congenital partial lipodystrophy (CPLD) and/or mandibular dysplasia with lipodystrophy (MAD). Recently, MDPL syn...
Source: Endocrine Journal - December 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Re-evaluation of MIB-1 immunostaining for diagnosing hyalinizing trabecular tumour of the thyroid: semi-automated techniques with manual antigen retrieval are more accurate than fully automated techniques.
Authors: Takada N, Hirokawa M, Ohbayashi C, Nishikawa T, Itoh T, Imagawa N, Oyama T, Handa T, Hasegawa T, Sugita S, Murata A, Miyauchi A Abstract Hyalinizing trabecular tumour (HTT) immunohistochemically shows cell membranous immunoreactivity for MIB-1. This aberrant immunoreactivity is an important factor for the diagnosis of HTT. However, fully automated stainers frequently fail to confirm the immunoreactivity. The aim of this study is to investigate the cause of false negative cell membranous immunoreactivity for MIB-1 in HTT using fully automated stainers, to determine potential reasons for the problem, and to ...
Source: Endocrine Journal - December 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Paraganglioma as a risk factor for bone metastasis.
Authors: Yokomoto-Umakoshi M, Umakoshi H, Tsuiki M, Ogasawara T, Hamanaka-Hiroshima K, Tanabe A, Tagami T, Shimatsu A, Naruse M Abstract Malignant pheochromocytoma (PHEO) and paraganglioma (PGL) (PHEO and PGL: PPGL) are frequently associated with bone metastasis. Bone metastasis requires long-term management and may lead to skeletal-related events (SREs) that remarkably reduce patients' quality of life (QOL). The aim of this study was to elucidate the risk factors for developing bone metastasis in patients with PPGL. The medical records of 40 consecutive adult patients with malignant PPGL at the National Hospital O...
Source: Endocrine Journal - December 2, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Impact of macroprolactin on galactorrhea and the rate of patients possibly affected by macroprolactin.
Authors: Aisaka K, Tsuchiya F, Sueta M, Itabashi K, Nose S, Hasegawa A, Obata S, Hiraike H, Yokoyama T Abstract The clinical influence of macroprolactin (MPRL) is not clearly understood and the rate of patients potentially affected by MPRL is unknown. We investigated the influence of MPRL on the onset of galactorrhea and estimated the rate of patients with a proportion of MPRL fraction that may possibly affect galactorrhea. Data of patients with obstetric or gynecological symptoms who had undergone PRL fractionation testing were retrospectively analyzed. To evaluate factors influencing galactorrhea, a multivariate ...
Source: Endocrine Journal - November 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
In conclusion, FRAX without femoral neck BMD reflects bone status, and may be useful to diagnose osteoporosis in Japanese women aged 55 and above, although the sensitivity was low for osteoporosis screening, especially in middle-aged women. PMID: 29151451 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 22, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Mismatch between fetal sexing and birth phenotype: a  case of complete androgen insensitivity syndrome.
Mismatch between fetal sexing and birth phenotype: a case of complete androgen insensitivity syndrome. Endocr J. 2017 Nov 09;: Authors: Yoshii K, Naiki Y, Terada Y, Fukami M, Horikawa R Abstract With advancing maternal age, the number of prenatal genetic tests is increasing in many countries. Prenatal genetic tests, such as amniocentesis, chorionic villus sampling and non-invasive prenatal testing, can disclose fetal chromosomal sex, although these tests were originally designed to prenatally diagnose chromosomal aneuploidies, such as trisomy 21, 18 and 13. Complete androgen insensitivity syndrome...
Source: Endocrine Journal - November 11, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats.
In conclusion, the increased expression of EPOR by hyperglycemia is mainly associated with an augmented expression of nuclear STAT3, which was identified both in vivo and in vitro in the present study. PMID: 29109360 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of two doses of Norditropin ® (somatropin) in short stature due to Noonan syndrome: a 2-year randomized, double-blind, multicenter trial in Japanese patients.
Efficacy and safety of two doses of Norditropin® (somatropin) in short stature due to Noonan syndrome: a 2-year randomized, double-blind, multicenter trial in Japanese patients. Endocr J. 2017 Nov 07;: Authors: Ozono K, Ogata T, Horikawa R, Matsubara Y, Ogawa Y, Nishijima K, Yokoya S Abstract This randomized double-blind multicenter trial (NCT01927861) evaluated the growth-promoting effect and safety of Norditropin(®) (NN220; somatropin) in Japanese children with short stature due to Noonan syndrome. Prepubertal children aged 3-
Source: Endocrine Journal - November 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes -Randomized controlled study.
Authors: Oita M, Miyoshi H, Ono K, Nakamura A, Cho KY, Nomoto H, Yamamoto K, Omori K, Manda N, Kurihara Y, Aoki S, Atsumi T Abstract We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) ...
Source: Endocrine Journal - November 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Warthin-like papillary thyroid carcinoma with immunoglobulin G4-positive plasma cells possibly related to Hashimoto's thyroiditis.
This study is the first to demonstrate the presence of IgG4(+)PCs in the stroma of WL-PTC. We concluded that the appearance of IgG4(+)PCs in the stroma of WL-PTC may be related to Hashimoto's thyroiditis with rich IgG4(+)PC. PMID: 29093307 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals.
In conclusion, although cecal intubation during colonoscopy was successful in all participants, it required a longer time in patients with acromegaly. Our results underscore the importance of and certain technical difficulties involved in colonoscopy procedures in patients with acromegaly, especially in older patients. PMID: 29081443 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 1, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017].
Authors: Hirokawa M, Kudo T, Ota H, Suzuki A, Kobayashi K, Miyauchi A Abstract Abstract, Table 4, and the paragraph of "Diagnostic accuracy (Table 4)" on page 863 contain some typographical errors. There are some typographical errors on page 864. PMID: 29081471 [PubMed - in process] (Source: Endocrine Journal)
Source: Endocrine Journal - November 1, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The synergic effect of BRAF(V600E) mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma.
Authors: Qu HJ, Qu XY, Hu Z, Lin Y, Wang JR, Zheng CF, Tan Z Abstract The purpose of this study is to evaluate the potential synergic effect of BRAF(V600E) mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAF(V600E) mutat...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study.
This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled. The following parameters were evaluated at baseline (before treatment), and after 24 weeks of GH replacement therapy: endothelial function using the reactive hyperemia index (RHI; EndoPAT(®) system), d-ROMs, blood pressure, and fasting lipid levels. Plasma ...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Ghrelin protects adult rat hippocampal neural stem cells from excessive autophagy during oxygen-glucose deprivation.
In conclusion, our data suggest that ghrelin protects adult rat hippocampal NSCs from excessive autophagy in experimental stroke (oxygen-glucose deprivation) model. Regulating autophagic activity may be a potential optimizing target for promoting adult rat hippocampal NSCs based therapy for stroke. PMID: 29057768 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - October 24, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly.
In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p
Source: Endocrine Journal - October 20, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy.
Authors: He L, Shen C, Zhang Y, Chen Z, Ding H, Liu J, Zha B Abstract Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Pregnant women with sufficient iodine intake and normal antithyroid antibodies during the second trimester were recruited from the obstetric outpatient department of the Fifth People's Hospital of Fudan University. Serum ferritin (SF...
Source: Endocrine Journal - October 17, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.
In this study we investigated the physiological roles of p62 by inactivating p62 in a β-cell specific manner. We found that firstly, rat insulin-2 promoter-Cre (RIP-Cre)-mediated p62 inactivation did not cause body weight gain, although ubiquitous inactivation of p62 was previously shown to result in severe obesity. Secondly, we found no gross structural disorganization of the islets of p62-deficient mice. Consistent with normal islet morphology, no impairment in glucose tolerance was observed in mice with RIP-Cre-mediated p62 deletion. These results suggest that p62 is dispensable for normal islet organization and &b...
Source: Endocrine Journal - October 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Which cytokine is the most related to weight loss- ‍induced decrease in arterial stiffness in overweight and obese men?
Which cytokine is the most related to weight loss-‍induced decrease in arterial stiffness in overweight and obese men? Endocr J. 2017 Sep 30;: Authors: Kumagai H, Zempo-Miyaki A, Yoshikawa T, Eto M, So R, Tsujimoto T, Nishiyasu T, Tanaka K, Maeda S Abstract Obesity and increased arterial stiffness are risk factors for cardiovascular disease. A well-known characteristic of obesity is the chronic low-grade inflammatory state, and it causes elevation of arterial stiffness. Weight-loss reduces arterial stiffness and inflammatory level in obese individuals. However, it is unclear which inflammatory fact...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Interaction between bone and glucose metabolism [Review].
Authors: Kanazawa I Abstract Accumulating evidence has shown that bone and glucose metabolism are closely associated with each other. Since the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM), osteoporosis is recently recognized as one of diabetic complications, called DM-induced bone fragility. Previous studies showed that collagen cross-links of advanced glycation end products (AGEs) and dysfunctions of osteoblast and osteocyte are involved in DM-induced bone fragility. Circulating levels of AGEs and homocysteine are increased in patients with DM, and they directly impair the f...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

A case report of fulminant type 1 diabetes mellitus associated with drug-induced hypersensitivity syndrome in an elderly patient with coxsackie B4 virus infection and human leukocyte antigen-A24 haplotype.
Authors: Takeno A, Kanazawa I, Morita M, Takedani K, Miyake H, Yamamoto M, Nogami K, Kaneko S, Sugimoto T Abstract Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-yea...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Neuropeptide Y promotes adipogenic differentiation in primary cultured human adipose-derived stem cells.
Authors: Liu M, Liu H, Liang F, Song XQ, Hu PA Abstract Neuropeptide Y (NPY) is an important neurotransmitter in the control of energy metabolism. Several studies have shown that obesity is associated with increased levels of NPY in the hypothalamus. We hypothesized that the release of NPY has coordinated and integrated effects on energy metabolism in different tissues, such as adipocyte tissue, resulting in increased energy storage and decreased energy expenditure. Whether NPY has role in the molecular mechanism of human adipocyte tissue remains unclear. We established the model of human adipose derived stem cells...
Source: Endocrine Journal - September 30, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The efficacy of medical treatment in patients with acromegaly in clinical practice.
Authors: Young Lee S, Hee Kim J, Hyun Lee J, Hwy Kim Y, Jin Cha H, Wan Kim S, Ha Paek S, Soo Shin C Abstract Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (4...
Source: Endocrine Journal - September 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.
Authors: Kurosawa H, Saisho Y, Fukunaga K, Haraguchi M, Yamasawa W, Kurihara I, Betsuyaku T, Itoh H Abstract Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPAP) therapy was introduced (N = 115, 44 with T2DM, age 62 ± 11 years, BMI 27.0 ± 4.4 kg/m(2) and AHI median 36.1; interquartile range 27.2-48.1). During admission, the severity o...
Source: Endocrine Journal - September 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of subgroup analysis stratified by baseline HbA1c in a Japanese phase 3 study of dulaglutide 0.75 mg compared with insulin glargine in patients with type 2 diabetes.
Authors: Kaneko S, Oura T, Matsui A, Shingaki T, Takeuchi M Abstract The efficacy and safety of once-weekly dulaglutide 0.75 mg (dulaglutide) compared with once-daily insulin glargine (glargine) in Japanese patients with type 2 diabetes were evaluated according to subgroups stratified by baseline glycated hemoglobin (HbA1c) (≤8.5% or>8.5%). This exploratory analysis of a randomized, open-label, phase 3 study included 361 patients. In both HbA1c subgroups (patients with baseline HbA1c ≤8.5% or>8.5%), a statistically significantly greater reduction in HbA1c was observed in dulaglutide-treated patients com...
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research