TSH ratio as a novel diagnostic method for Cushing's syndrome.
Authors: Tamada D, Kitamura T, Takahara M, Tanaka T, Takeda M, Otsuki M, Shimomura I Abstract Circadian variations impact thyrotropin (TSH) secretion; in Cushing's syndrome (CS) patients, the nocturnal serum TSH surge is abolished. The aim of this prospective study is to examine whether serum TSH surge may be a useful diagnostic method for CS. This prospective study recruited 136 inpatients for differential diagnosis of CS or subclinical CS (SCS), and 21 inpatients with depression at Osaka University Hospital. Serum TSH surge was assessed by the midnight-to-morning serum TSH ratio (2300-2400 h to 0800-0900 h). The ...
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of lipoprotein-associated phospholipase A2 inhibitor on insulin resistance in streptozotocin-induced diabetic pregnant rats.
Authors: Wang GH, Jin J, Sun LZ Abstract This paper aims to investigate the influence of lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, darapladib, on insulin resistance (IR) in streptozotocin (STZ)-induced diabetic pregnant rats. The rat models were divided into Control (normal pregnancy), STZ + saline (STZ-induced diabetic pregnant rats), STZ + Low-dose and STZ + High-dose darapladib (STZ-induced diabetic pregnant rats treated with low-/high-dose darapladib) groups. Pathological changes were observed by Hematoxylin-eosin (HE) and Immunohistochemistry staining. Lp-PLA2 levels were determined by enzym...
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

False-positive TSH receptor antibody results in an infant with activating TSHR mutation.
Authors: Wong FC, Au EY, Ip RW, Yau HC, Lit LC PMID: 29925745 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 23, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Postoperative growth hormone dynamics in clinically nonfunctioning pituitary adenoma.
In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion. We also investigated how several factors affected GH dynamics. Of 119 patients analyzed, 94 (79.0%) had peak GH levels less than 9.0 ng/mL and were diagnosed with severe GHD (sGHD) immediately after surgery. Of those patients, 27 (28.7%) recovered from sGHD within 1-2 years after surgery. Univariate analyses confirmed that sGHD recovery improved significantly in patients that were younger, had only undergone a single primary surgery, had n...
Source: Endocrine Journal - June 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of total testosterone, free testosterone, bioavailable testosterone and sex hormone-binding globulin with hepatic steatosis and the ratio of aspartate aminotransferase to alanine aminotransferase.
In conclusion, higher TT and SHBG levels in men are associated with the reduced risk of hepatic steatosis and elevated AST/ALT ratios, independent of age, smoking, alcohol consumption and physical activity. PMID: 29910248 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the  expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.
Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway. Endocr J. 2018 Jun 09;: Authors: Lin YC, Chiu CH, Liu HC, Wang JY Abstract Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our enzyme immunoassay results showed that cu...
Source: Endocrine Journal - June 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI).
Authors: Babinska A, Kaszubowski M, Sworczak K Abstract Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor &...
Source: Endocrine Journal - June 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Caveolin-1 regulates autophagy activity in thyroid follicular cells and is involved in Hashimoto's thyroiditis disease.
In this study, we examined Th1 cytokines and Cav-1 expression in HT thyroid tissues, determined the effects of interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ) on Cav-1 and autophagy activity in TFC, and investigated the association between Cav-1 and autophagy activity in vitro. Our results indicate that higher levels of IL-1β and IFN-γ and lower levels of Cav-1 were expressed in thyroid tissues of HT patients than in those of normal controls. Cav-1 mRNA and protein levels were significantly decreased in TFC exposed to IL-1β and IFN-γ, accompanied by decreased expression of autophagy-...
Source: Endocrine Journal - June 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases.
In conclusion, the CRTH2 rs545659 and rs634681 SNPs were associated with the severity of HD, and the TARC/CCL17 rs223828 SNP was associated with the intractability of GD. PMID: 29848886 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - June 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Improved cardiometabolic risk factors in Japanese patients with type 2 diabetes treated with ipragliflozin: a pooled analysis of six randomized, placebo-controlled trials.
Authors: Kashiwagi A, Sakatani T, Nakamura I, Akiyama N, Kazuta K, Ueyama E, Takahashi H, Kosakai Y Abstract To examine differential improvements among cardiovascular risk factors in response to treatment with ipragliflozin in Japanese type 2 diabetes mellitus (T2DM) patients, we conducted a pooled analysis of six randomized, double-blind trials of Japanese T2DM patients who received ipragliflozin 50 mg/day or placebo and had patient-level data for cardiometabolic risk parameters. Risk factors included glycated hemoglobin (HbA1c), body weight, homeostatic model assessment for insulin resistance and beta-cell functi...
Source: Endocrine Journal - June 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Transducin β-like 1, X-linked and nuclear receptor co-‍repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors.
Transducin β-like 1, X-linked and nuclear receptor co-‍repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors. Endocr J. 2018 May 23;: Authors: Takamizawa T, Satoh T, Miyamoto T, Nakajima Y, Ishizuka T, Tomaru T, Yoshino S, Katano-Toki A, Nishikido A, Sapkota S, Watanabe T, Okamura T, Ishida E, Horiguchi K, Matsumoto S, Ishii S, Ozawa A, Shibusawa N, Okada S, Yamada M Abstract Mutations in TBL1X, a component of the nuclear receptor co-repressor (N-CoR) and silencing mediator of retinoic acid and thyroid hormone recept...
Source: Endocrine Journal - May 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the  Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.
Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes. Endocr J. 2018 May 22;: Authors: Shiga K, Urakami T, Suzuki J, Igarashi Y, Tajima H, Amemiya S, Sugihara S, Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) Abstract Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1...
Source: Endocrine Journal - May 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The relationship between vitronectin and hepatic insulin resistance in type 2 diabetes mellitus.
In this study, we aimed to compare the plasma vitronectin (VN) levels between patients with T2DM and insulin resistance (IR) and healthy controls. Seventy patients with IR and 70 age- and body mass index (BMI)-matched healthy controls were included in the study. The insulin, Waist-to-Hip Ratio (WHR), C-peptide (CP) and VN levels of all participants were examined. The homeostasis model of assessment for insulin resistence index (HOMA-IR (CP)) formula was used to calculate insulin resistance. The levels of BMI, fasting plasma gluose (FPG), 2-hour postprandial glucose (2hPG), glycated hemoglobins (HbA1c), and HOMA-IR (CP) wer...
Source: Endocrine Journal - May 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Metyrapone-responsive ectopic ACTH-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism.
Authors: Inoue M, Okamura K, Kitaoka C, Kinoshita F, Namitome R, Nakamura U, Shiota M, Goto K, Ohtsubo T, Matsumura K, Oda Y, Eto M, Kitazono T Abstract In ectopic ACTH-secreting pheochromocytoma, combined ACTH-driven hypercortisolemia and hyper-catecholaminemia are serious conditions, which can be fatal if not diagnosed and managed appropriately, especially when glucocorticoid-driven positive feedback is suggested with a high ACTH/cortisol ratio. A 46-year-old man presented with headache, rapid weight loss, hyperhidrosis, severe hypertension and hyperglycemia without typical Cushingoid appearance. Endocrinological...
Source: Endocrine Journal - May 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Identification of urinary biomarkers for the prediction of gestational diabetes mellitus in early second trimester of young gravidae based on iTRAQ quantitative proteomics.
Authors: Guo Y, Han Z, Guo L, Liu Y, Li G, Li H, Zhang J, Bai L, Wu H, Chen B Abstract Gestational Diabetes Mellitus (GDM) has brought great harm to maternal and fetus. Up to now, only a few plasma biomarkers for its early diagnosis have been reported; nevertheless, there is no report about identification of urinary biomarkers for prediction of GDM. Thus, it is necessary to correct this deficiency. In our study, urine samples were collected from 889 healthy young gravidae at the early second trimester (15 to 20 weeks), 69 of whom were subsequently diagnosed with GDM at 24 to 28 weeks. iTRAQ (the isobaric tags for r...
Source: Endocrine Journal - May 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Hydrogen sulfide ameliorates rat myocardial fibrosis induced by thyroxine through PI3K/AKT signaling pathway.
This study aims to investigate the role and regulatory mechanism of the Hydrogen sulfide (H2S) in amelioration of rat myocardial fibrosis induced by thyroxine through interfering the autophagy via regulating the activity of PI3K/AKT1 signaling pathway and the expression of relative miRNA. 40 adult male SD rats were randomly divided into 4 groups (n = 10): the control group, the thyroxine model group (TH group), the model group with H2S intervention (TH + H2S group) and the normal group with H2S intervention (H2S group). Pathological changes were observed via H&E staining and Masson staining, Expressions of MMPs/TIMPs, ...
Source: Endocrine Journal - May 12, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Angiotensin II aggravates lipopolysaccharide induced human pulmonary microvascular endothelial cells permeability in high glucose status.
This study suggests that in a diabetic infectious lung injury cellular model, AngII could aggravate the permeability of HPMVEC via F-actin dynamics and cell apoptosis. Furthermore, blocking the Angiotension II Type 1 Receptor could significantly alleviate the hyperpermeability of HPMVECs. PMID: 29709898 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - May 2, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case of TSH-secreting pituitary adenoma with cyclic fluctuations in serum TSH levels.
Authors: Okuma H, Hashimoto K, Ohashi T, Mihara M, Minami I, Izumiyama H, Sasaki S, Inoshita N, Nishioka H, Yamada S, Yoshimoto T Abstract A 29-year-old man was referred to our department due to adrenal insufficiency with the inappropriate secretion of TSH (SITSH). Magnetic resonance imaging revealed a pituitary tumor. A weak TSH response in the TRH test, elevated sex hormone binding globulin (SHBG) levels, and the absence of a family medical history of SITSH or TRβ gene mutations supported the diagnosis of TSH-secreting pituitary adenoma (TSHoma). However, complete TSH suppression and a blunted cholesterol re...
Source: Endocrine Journal - April 28, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Prognostic value of the 8th edition of the tumor-node-metastasis classification for patients with papillary thyroid carcinoma: a single-institution study at a high-volume center in Japan.
Authors: Ito Y, Miyauchi A, Hirokawa M, Yamamoto M, Oda H, Masuoka H, Sasai H, Fukushima M, Higashiyama T, Kihara M, Miya A Abstract The tumor-node-metastasis (TNM) staging system is most commonly adopted to evaluate the prognosis of patients with thyroid carcinoma. The 8th edition of the TNM staging system, an extensively revised version of the 7th edition, was recently released. We aimed to investigate whether and how well the 8th edition reflects the cause-specific survival (CSS) of patients with papillary thyroid carcinoma by analyzing the cases in 5,892 patients who underwent initial surgery at Kuma Hospital b...
Source: Endocrine Journal - April 25, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index.
Authors: Zang H, Jiang F, Cheng X, Xu H, Hu X Abstract Adropin has been identified as potent regulatory hormone implicated in insulin sensitivity and the maintenance of energy homeostasis. The aim of current study was to investigate serum adropin concentrations of type 2 diabetes mellitus (T2DM) patients in the fasting status, especially those overweight/obese and evaluate the relationships between adropin levels and metabolic parameters. A total of 116 T2DM patients and 60 controls with normal glucose tolerance (NGT) were recruited to the study. Adropin concentration was determined using commercial ELISA kits. Ant...
Source: Endocrine Journal - April 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.
Authors: Chen B, Li Z, Chen J, Ji J, Shen J, Xu Y, Zhao Y, Liu D, Shen Y, Zhang W, Shen J, Wang Y, Shi Y Abstract Body mass index (BMI) is the most commonly used quantitative measure of adiposity. It is a kind of complex genetic diseases which are caused by multiple susceptibility genes. The first intron of fat mass and obesity-associated (FTO) has been widely discovered to be associated with BMI. Retinitis pigmentosa GTPase regulator-interacting protein-1 like (RPGRIP1L) is located in the upstream region of FTO and has been proved to be linked with obesity through functional tests. We carried out a genetic associa...
Source: Endocrine Journal - April 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Proposed cut-off value of CA19-9 for detecting pancreatic cancer in patients with diabetes: a case-control study.
This study evaluated the sensitivity, specificity, and cut-off value of serum CA19-9 for detection of pancreatic cancer in patients with diabetes. A case-control study of 236 patients was performed. The case group was selected from diabetic patients with pancreatic cancer, while one control was selected for each case from among diabetic patients without pancreatic cancer during the same period. The case group (n = 118) and the control group (n = 118) were matched for age, sex, and pancreatic cancer risk factors. Receiver operating characteristic (ROC) curves were plotted to determine the serum CA19-9 level that predicted p...
Source: Endocrine Journal - April 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Clinical and molecular characterization of 5 α-reductase type 2 deficiency due to mutations (p.Q6X, p.R246Q) in SRD5A2 gene.
In conclusion, we analyzed the genotype-phenotype correlations of 5α-RD2 caused by a heterozygotes mutation (p.Q6X, p.R246Q). Importantly, we conducted the homology modeling and molecular docking for the first time, which provided a homology model for further investigations. Immunohistochemical results suggested gonadectomy or testis descent should be performed early for 5α-RD2 patient, as delayed treatment would have maintained the testes in a tumorigenic condition. PMID: 29643321 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - April 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study.
Authors: Okamura T, Hashimoto Y, Hamaguchi M, Ohbora A, Kojima T, Fukui M Abstract Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis. We used common clinic...
Source: Endocrine Journal - April 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of linagliptin versus voglibose on treatment-related quality of life in patients with type 2 diabetes: sub-analysis of the L-STEP study.
Authors: Goto H, Mita T, Fujitani Y, Fujimoto S, Takahashi K, Satoh H, Hirose T, Hiyoshi T, Ai M, Okada Y, Nishimura H, Kuroda H, Matsubara T, Gosho M, Ishii H, Watada H Abstract Treatment-related quality of life (QOL) is an important aspect of diabetes management. However, no studies have compared the influence of dipeptidyl peptidase-4 inhibitors versus alpha-glucosidase inhibitors on treatment-related QOL. This prespecified sub-analysis of the Linagliptin Study of Effects on Postprandial blood glucose (L-STEP) compared the effects of linagliptin (5 mg once daily) and voglibose (0.2 mg/meal thrice daily) on treat...
Source: Endocrine Journal - April 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Usage of continuous glucose monitoring (CGM) for detecting an unrecognized hypoglycemia and management of glucocorticoid replacement therapy in adult patients with central hypoadrenalism.
Authors: Watanabe T, Ozawa A, Ishii S, Tomaru T, Shibusawa N, Saito T, Yamada E, Horiguchi K, Nakajima Y, Matsumoto S, Yoshino S, Katano-Toki A, Hashimoto K, Mori M, Okada S, Satoh T, Yamada M Abstract Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestive of over- or under-replacement. We have found that some patients who are viewed as receiving suffici...
Source: Endocrine Journal - April 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Prognostic value of the 8th tumor-node-metastasis classification for follicular carcinoma and poorly differentiated carcinoma of the thyroid in Japan.
In this study, we investigated whether these changes are appropriate for accurately predicting prognosis. Three hundred and twenty-nine patients diagnosed with postoperative pathologically confirmed FTC, who underwent initial surgery at our hospital between 1984 and 2004, were enrolled. For this study, patients were re-evaluated and diagnosed with FTC (N = 285) or PDC (N = 44) without typical nuclear findings of papillary thyroid carcinoma. For FTC, the 8th TNM classification was a more accurate predictor of prognosis than the 7th TNM classification. In the 8th TNM classification, cause-specific survival became significant...
Source: Endocrine Journal - April 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Eldecalcitol increases bone mass in patients with Turner syndrome who have insufficient bone mass acquisition after estrogen replacement therapy.
This study was conducted in two stages, involving a cross-sectional and a prospective interventional study. We recruited 52 TS patients undergoing ERT due to amenorrhea (categorized into low (LB group; n = 23), and normal (NB group; n = 29) bone mass groups) and 7 TS patients who maintained ovarian function (spontaneous menstrual cycle group (MC group)) as controls. We compared bone associated markers between the three groups (LB, NB, and MC). Furthermore, the LB group had concomitant treatment with eldecalcitol (ELD) and ERT for 12 months. The bone mineral density (BMD) of the lumber spine (L2-4) and the bone metabolism m...
Source: Endocrine Journal - April 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Poor toe flexor strength, but not handgrip strength, is associated with the prevalence of diabetes mellitus in middle-aged males.
Authors: Suwa M, Imoto T, Kida A, Yokochi T, Iwase M, Kozawa K Abstract Previous studies suggested that reduced muscular strength was one of the potential predictor of prevalence of diabetes mellitus. The purpose of this study was to investigate the association between toe flexor strength (TFS) and handgrip strength (HGS) and the prevalence of diabetes mellitus. Cross-sectional analysis was conducted using data from 1,390 Japanese males (35-59 years). TFS and HGS were measured and medical examinations undertaken. The prevalence of diabetes mellitus was defined as fasting blood glucose ≥126 mg/dL, glycated hemogl...
Source: Endocrine Journal - March 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Optimal weight gain in obese and overweight pregnant Japanese women.
Authors: Hirooka-Nakama J, Enomoto K, Sakamaki K, Kurasawa K, Miyagi E, Aoki S Abstract We aimed to determine the optimal gestational weight gain (GWG) in Japanese women with a Body Mass Index (BMI) ≥25 kg/m2. The present retrospective study investigated singleton pregnancies in 6,781 Japanese women registered in the Japan Society of Obstetrics and Gynecology system in 2013. We divided overweight and obese women into four GWG categories based on the Institute of Medicine (IOM) recommended: weight loss, small weight gain, within IOM criteria, and above IOM criteria. The adjusted odds ratios and predicted probabil...
Source: Endocrine Journal - March 28, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

New diagnostic criteria of adrenal subclinical Cushing's syndrome: opinion from the Japan Endocrine Society.
Authors: Yanase T, Oki Y, Katabami T, Otsuki M, Kageyama K, Tanaka T, Kawate H, Tanabe M, Doi M, Akehi Y, Ichijo T Abstract New diagnostic criteria and the treatment policy for adrenal subclinical Cushing's syndrome (SCS) are proposed on behalf of the Japan Endocrine Society. The Japanese version has been published, and the essential contents are presented in this English-language version. The current diagnostic criteria for SCS have elicited two main problems: (i) the relatively low reliability of a low range of serum cortisol essential for the diagnosis by an overnight 1-mg dexamethasone suppression test (DST); (...
Source: Endocrine Journal - March 28, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Tumor necrosis factor alpha improves glucose homeostasis in diabetic mice independent with tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2.
Authors: Wu S, Dong K, Wang J, Bi Y Abstract Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes. And tumor necrosis factor alpha (TNF-α) is one of the most important cytokines related with obesity. To explore the functional role of TNF-α in the regulation of glucose homeostasis, TNF-α receptor 1 and TNF-α receptor 2 double knockout (TNFR1/R2 DKO) mouse model were used in our study. ...
Source: Endocrine Journal - March 28, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Derivation of thyroid lymphoepithelial cysts from follicular cells.
Authors: Suzuki A, Hirokawa M, Ito A, Takada N, Higuchi M, Hayashi T, Kuma S, Daa T, Miyauchi A Abstract The pathogenesis of thyroid lymphoepithelial cysts is controversial, and two hypotheses have been proposed, namely derivation from branchial-derived remnants or from squamous metaplasia of the follicular cells. The aim of this study was to clarify the pathogenesis of thyroid lymphoepithelial cysts. We performed pathological and immunohistochemical examination of 21 thyroid lymphoepithelial cysts, 13 non-neoplastic squamous metaplasia samples without thyroid carcinoma, 13 solid cell nests, and 14 lateral cervical...
Source: Endocrine Journal - March 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey.
This study aimed to examine 12-year trends of increasing obesity in Japanese patients with diabetes, and their clinical features. The study used results of the Shiga Diabetes Clinical Survey, which recorded medical performance in diabetic patients in 2000, 2006 and 2012. Data were analyzed from 14,205, 14,407 and 21,449 adult patients in these three years, respectively. Overweight and obesity prevalence and the clinical features of diabetes patients were examined, stratified by body mass index (BMI) and age. The prevalence of overweight (BMI 25-30 kg/m2) and obesity (BMI ≥30 kg/m2) were 27.0% and 5.1% in 2000, 28.9% and...
Source: Endocrine Journal - March 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

False-positive TSH receptor antibody-a pitfall of third-generation TSH receptor antibody measurements in neonates.
Authors: Wada M, Kita M, Kawasaki K, Kusakabe T, Tagami T, Satoh-Asahara N, Shimatsu A, Hashimoto K Abstract Maternal Graves' disease (GD) during pregnancy may influence thyroid function in fetuses. Neonates born to mothers with high serum TSH receptor antibody (TRAb) levels have been reported to develop 'neonatal GD'. Therefore, evaluations of serum thyroid hormone and TRAb levels in neonates upon birth are crucial for a prompt diagnosis. At delivery, we measured TRAb with third-generation TRAb test using an M22 human monoclonal antibody in neonates by collecting umbilical cord blood in a blood collection tube wit...
Source: Endocrine Journal - March 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Protective effects of astaxanthin on a combination of D- ‍galactose and jet lag-induced aging model in mice.
In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model. PMID: 29526991 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - March 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan.
Authors: Kubota T, Nakayama H, Kitaoka T, Nakamura Y, Fukumoto S, Fujiwara I, Hasegawa Y, Ihara K, Kitanaka S, Koyama S, Kusuda S, Mizuno H, Nagasaki K, Oba K, Sakamoto Y, Takubo N, Shimizu T, Tanahashi Y, Hasegawa K, Tsukahara H, Yorifuji T, Michigami T, Ozono K Abstract There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia fo...
Source: Endocrine Journal - March 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Prevalence of diverse complications and its association with karyotypes in Japanese adult women with Turner syndrome-a questionnaire survey by the Foundation for Growth Science.
In conclusion, the more exact prevalence of diverse complications was clarified and it exceeded the prevalence of the majority of complications in general population. As novel findings, it was observed that the prevalence of epilepsy was significantly high, and epilepsy and low BMD were frequently associated with the specific karyotypes. PMID: 29515055 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - March 9, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps.
This study aimed to compare the quality of life (QOL) of diabetic patients with and without muscle cramps and to investigate the effect of L-carnitine supplementation in diabetic patients with muscle cramps. A total of 91 patients with diabetes were enrolled in this study: 69 patients with muscle cramps and 22 patients without muscle cramps. Muscle cramps and QOL were evaluated using the muscle cramp questionnaire and the Short Form 36 health survey version 2 (SF-36), respectively. Clinical characteristics were compared between diabetic patients with and without muscle cramps. In the prospective portion of the study, 25 di...
Source: Endocrine Journal - March 9, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Divergent patterns of genic copy number variation in KCNIP1 gene reveal risk locus of type 2 diabetes in Chinese population.
Authors: Xu Y, Shi W, Song R, Long W, Guo H, Yuan S, Zhang T Abstract Copy number variation (CNV) has emerged as another important genetic marker in addition to SNP for understanding etiology of complex disease. Kv channel interacting protein 1 (KCNIP1) is a Ca2+-dependent transcriptional modulator that contributes to the regulation of insulin secretion. Previous genome-wide CNV assay identified the KCNIP1 gene encompassing a CNV region, however, its further effect and risk rate on type 2 diabetes (T2D) have rarely been addressed, especially in Chinese population. The current study aims to detect and excavate genet...
Source: Endocrine Journal - March 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women.
Authors: Yuan XS, Zhang M, Wang HY, Jiang J, Yu B Abstract By biochemical and epidemiological similarity with type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) has some overlap between prediction markers and risk factors of T2DM. The present study aimed to establish that secreted frizzled-related protein 4 (SFRP4) and ficolin-3 levels, which have been linked to insulin resistance and the development of T2DM, are elevated in GDM women. A longitudinal prospective cohort study of 86 GDM and 273 normal glucose tolerant (NGT) pregnant women was performed. The clinical parameters, lipid profiles, and s...
Source: Endocrine Journal - March 3, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents.
Authors: Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Iwasa T, Yano K, Mayila Y, Tokui T, Yanagihara R, Matsui S, Kato T, Kuwahara A, Irahara M Abstract Kisspeptin/neurokinin B (NKB)/dynorphin (Dyn) (KNDy) neuron in hypothalamic arcuate nucleus plays a key role in GnRH/LH pulsatile secretion. We aimed to determine whether stimulation of NKB/neurokinin 3 receptor (NK3R) signaling and inhibition of Dyn/kappa-opioid receptor (KOR) signaling recover LH secretion that is suppressed by acute fasting in male rats. Furthermore, we determined dose dependent effect of NKB/NK3R signaling on serum LH level under acute fasting con...
Source: Endocrine Journal - February 27, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Berberine inhibits glucose oxidation and insulin secretion in rat islets.
Authors: Bai M, Liu Y, Zhou F, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Wang X, Zhou L Abstract Glucose promotes insulin secretion primarily via its metabolism and the production of metabolic coupling factors in beta-cells. The activation of AMP-activated protein kinase (AMPK), an energy sensor, results in a decrease in insulin secretion from beta-cells, but its mechanism remains largely unknown. Berberine, an oral anti-diabetic drug, has been shown to activate AMPK in multiple peripheral tissues. Here, we examined the effects of berberine and AMPK activation on insulin secretion and glucose oxidation in ra...
Source: Endocrine Journal - February 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes.
In conclusion, SGLT2i reduced not only HbA1c, BW and BMI but also AHI significantly and therefore has potential as an effective treatment of OSAS. PMID: 29459554 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Metabolic and immunological assessment of small-for-gestational-age children during one-year treatment with growth hormone: the clinical impact of apolipoproteins.
In conclusion, there was no evidence suggesting metabolic abnormalities in SGA children. Serum apolipoprotein changes might predict the beneficial role of GH treatment in lowering cardiometabolic risk. PMID: 29459555 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Concurrent variant type 3 autoimmune polyglandular syndrome and pulmonary arterial hypertension in a  Japanese woman.
We describe a very rare case of concurrent variant type 3 autoimmune polyglandular syndrome (APS) and pulmonary arterial hypertension (PAH). A previously healthy 65-year-old Japanese woman was referred to our university hospital with a 2-month history of general fatigue and hyperglycemia. Laboratory tests revealed severe hyperglycemia (plasma glucose 543 mg/dL and HbA1c 10.7%) with ketonuria (3+). Glutamic acid decarboxylase (GAD) and IA-2 antibodies were positive, and the serum C peptide level was markedly decreased to 0.2 ng/mL. Accordingly, type 1 diabetes was diagnosed. Hashimoto's thyroiditis was also diagnosed becaus...
Source: Endocrine Journal - February 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma.
Authors: Takenobu M, Moritani S, Yoshioka K, Morisaki T, Kitano H Abstract Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemoth...
Source: Endocrine Journal - February 17, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity.
Authors: Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi KS, Choo YS, Yoon D, Kim MO, Ryoo ZY Abstract Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a major role in angiogenesis and vasculogenesis. Previous study demonstrated that PlGF-overexpressing transgenic (Tg) mice had gestational loss. In addition, PlGF secretion was up-regulated in isolated T lymphocytes (T-cell) upon CD3/CD28 stimulation, suggesting that PlGF could be a regulator of T-cell differentiation and development. T-cells are well known to play a critical role in obe...
Source: Endocrine Journal - February 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Validation of simple indexes for nonalcoholic fatty liver disease in western China: a retrospective cross-sectional study.
This study was aimed to evaluate various indexes for NAFLD in western China. It was a retrospective cross-sectional study, using data from a large-scale health check-up project at Sichuan provincial hospital. Receiver operating characteristic (ROC) curves of eight indexes, including the fatty liver index (FLI), the hepatic steatosis index, lipid accumulation product and etc., were developed to predict ultrasonographic NAFLD. There were 13,122 subjects in this study (2,692 NAFLD patients and 10,430 non-NAFLD participants). The area under ROC curve of FLI for predicting NAFLD was 0.880 (95% confidence interval, 0.874-0.886),...
Source: Endocrine Journal - February 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type.
In conclusion, thyroid SMECE has favorable outcomes and seems to be genetically different from salivary MEC. This is the first report to describe the presence of increased IgG4-positive plasma cells in the stroma of SMECE. PMID: 29415898 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 10, 2018 Category: Endocrinology Tags: Endocr J Source Type: research