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Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats.
In conclusion, the increased expression of EPOR by hyperglycemia is mainly associated with an augmented expression of nuclear STAT3, which was identified both in vivo and in vitro in the present study. PMID: 29109360 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of two doses of Norditropin ® (somatropin) in short stature due to Noonan syndrome: a 2-year randomized, double-blind, multicenter trial in Japanese patients.
Efficacy and safety of two doses of Norditropin® (somatropin) in short stature due to Noonan syndrome: a 2-year randomized, double-blind, multicenter trial in Japanese patients. Endocr J. 2017 Nov 07;: Authors: Ozono K, Ogata T, Horikawa R, Matsubara Y, Ogawa Y, Nishijima K, Yokoya S Abstract This randomized double-blind multicenter trial (NCT01927861) evaluated the growth-promoting effect and safety of Norditropin(®) (NN220; somatropin) in Japanese children with short stature due to Noonan syndrome. Prepubertal children aged 3-
Source: Endocrine Journal - November 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes -Randomized controlled study.
Authors: Oita M, Miyoshi H, Ono K, Nakamura A, Cho KY, Nomoto H, Yamamoto K, Omori K, Manda N, Kurihara Y, Aoki S, Atsumi T Abstract We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) ...
Source: Endocrine Journal - November 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Warthin-like papillary thyroid carcinoma with immunoglobulin G4-positive plasma cells possibly related to Hashimoto's thyroiditis.
This study is the first to demonstrate the presence of IgG4(+)PCs in the stroma of WL-PTC. We concluded that the appearance of IgG4(+)PCs in the stroma of WL-PTC may be related to Hashimoto's thyroiditis with rich IgG4(+)PC. PMID: 29093307 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals.
In conclusion, although cecal intubation during colonoscopy was successful in all participants, it required a longer time in patients with acromegaly. Our results underscore the importance of and certain technical difficulties involved in colonoscopy procedures in patients with acromegaly, especially in older patients. PMID: 29081443 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 1, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017].
Authors: Hirokawa M, Kudo T, Ota H, Suzuki A, Kobayashi K, Miyauchi A Abstract Abstract, Table 4, and the paragraph of "Diagnostic accuracy (Table 4)" on page 863 contain some typographical errors. There are some typographical errors on page 864. PMID: 29081471 [PubMed - in process] (Source: Endocrine Journal)
Source: Endocrine Journal - November 1, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The synergic effect of BRAF(V600E) mutation and multifocality on central lymph node metastasis in unilateral papillary thyroid carcinoma.
Authors: Qu HJ, Qu XY, Hu Z, Lin Y, Wang JR, Zheng CF, Tan Z Abstract The purpose of this study is to evaluate the potential synergic effect of BRAF(V600E) mutation and multifocality on central lymph nodes metastasis (CLNM) in the patients with unilateral papillary thyroid carcinoma (PTC). We enrolled 413 patients with unilateral PTCs who accepted prophylactic unilateral or bilateral central lymph node dissection (LND). Univariate and multivariate analyses were made to determine the association between related factors and CLNM. Then, all patients were divided into 4 groups based on their status of BRAF(V600E) mutat...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study.
This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled. The following parameters were evaluated at baseline (before treatment), and after 24 weeks of GH replacement therapy: endothelial function using the reactive hyperemia index (RHI; EndoPAT(®) system), d-ROMs, blood pressure, and fasting lipid levels. Plasma ...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Ghrelin protects adult rat hippocampal neural stem cells from excessive autophagy during oxygen-glucose deprivation.
In conclusion, our data suggest that ghrelin protects adult rat hippocampal NSCs from excessive autophagy in experimental stroke (oxygen-glucose deprivation) model. Regulating autophagic activity may be a potential optimizing target for promoting adult rat hippocampal NSCs based therapy for stroke. PMID: 29057768 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - October 24, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly.
In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p
Source: Endocrine Journal - October 20, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy.
Authors: He L, Shen C, Zhang Y, Chen Z, Ding H, Liu J, Zha B Abstract Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Pregnant women with sufficient iodine intake and normal antithyroid antibodies during the second trimester were recruited from the obstetric outpatient department of the Fifth People's Hospital of Fudan University. Serum ferritin (SF...
Source: Endocrine Journal - October 17, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.
In this study we investigated the physiological roles of p62 by inactivating p62 in a β-cell specific manner. We found that firstly, rat insulin-2 promoter-Cre (RIP-Cre)-mediated p62 inactivation did not cause body weight gain, although ubiquitous inactivation of p62 was previously shown to result in severe obesity. Secondly, we found no gross structural disorganization of the islets of p62-deficient mice. Consistent with normal islet morphology, no impairment in glucose tolerance was observed in mice with RIP-Cre-mediated p62 deletion. These results suggest that p62 is dispensable for normal islet organization and &b...
Source: Endocrine Journal - October 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Which cytokine is the most related to weight loss- ‍induced decrease in arterial stiffness in overweight and obese men?
Which cytokine is the most related to weight loss-‍induced decrease in arterial stiffness in overweight and obese men? Endocr J. 2017 Sep 30;: Authors: Kumagai H, Zempo-Miyaki A, Yoshikawa T, Eto M, So R, Tsujimoto T, Nishiyasu T, Tanaka K, Maeda S Abstract Obesity and increased arterial stiffness are risk factors for cardiovascular disease. A well-known characteristic of obesity is the chronic low-grade inflammatory state, and it causes elevation of arterial stiffness. Weight-loss reduces arterial stiffness and inflammatory level in obese individuals. However, it is unclear which inflammatory fact...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Interaction between bone and glucose metabolism [Review].
Authors: Kanazawa I Abstract Accumulating evidence has shown that bone and glucose metabolism are closely associated with each other. Since the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM), osteoporosis is recently recognized as one of diabetic complications, called DM-induced bone fragility. Previous studies showed that collagen cross-links of advanced glycation end products (AGEs) and dysfunctions of osteoblast and osteocyte are involved in DM-induced bone fragility. Circulating levels of AGEs and homocysteine are increased in patients with DM, and they directly impair the f...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

A case report of fulminant type 1 diabetes mellitus associated with drug-induced hypersensitivity syndrome in an elderly patient with coxsackie B4 virus infection and human leukocyte antigen-A24 haplotype.
Authors: Takeno A, Kanazawa I, Morita M, Takedani K, Miyake H, Yamamoto M, Nogami K, Kaneko S, Sugimoto T Abstract Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic adverse drug reaction. Previous studies showed that DIHS is associated with the onset of fulminant type 1 diabetes mellitus (FT1D). Although genetic background and abnormalities in immune response or viral infection are considered to be associated with pathogenesis of FT1D, it remains unclear whether virus infection and specific human leukocyte antigen (HLA) typing are involved in DIHS-associated FT1D. Here, we report a case of a 78-yea...
Source: Endocrine Journal - October 3, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Neuropeptide Y promotes adipogenic differentiation in primary cultured human adipose-derived stem cells.
Authors: Liu M, Liu H, Liang F, Song XQ, Hu PA Abstract Neuropeptide Y (NPY) is an important neurotransmitter in the control of energy metabolism. Several studies have shown that obesity is associated with increased levels of NPY in the hypothalamus. We hypothesized that the release of NPY has coordinated and integrated effects on energy metabolism in different tissues, such as adipocyte tissue, resulting in increased energy storage and decreased energy expenditure. Whether NPY has role in the molecular mechanism of human adipocyte tissue remains unclear. We established the model of human adipose derived stem cells...
Source: Endocrine Journal - September 30, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The efficacy of medical treatment in patients with acromegaly in clinical practice.
Authors: Young Lee S, Hee Kim J, Hyun Lee J, Hwy Kim Y, Jin Cha H, Wan Kim S, Ha Paek S, Soo Shin C Abstract Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (4...
Source: Endocrine Journal - September 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.
Authors: Kurosawa H, Saisho Y, Fukunaga K, Haraguchi M, Yamasawa W, Kurihara I, Betsuyaku T, Itoh H Abstract Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPAP) therapy was introduced (N = 115, 44 with T2DM, age 62 ± 11 years, BMI 27.0 ± 4.4 kg/m(2) and AHI median 36.1; interquartile range 27.2-48.1). During admission, the severity o...
Source: Endocrine Journal - September 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of subgroup analysis stratified by baseline HbA1c in a Japanese phase 3 study of dulaglutide 0.75 mg compared with insulin glargine in patients with type 2 diabetes.
Authors: Kaneko S, Oura T, Matsui A, Shingaki T, Takeuchi M Abstract The efficacy and safety of once-weekly dulaglutide 0.75 mg (dulaglutide) compared with once-daily insulin glargine (glargine) in Japanese patients with type 2 diabetes were evaluated according to subgroups stratified by baseline glycated hemoglobin (HbA1c) (≤8.5% or>8.5%). This exploratory analysis of a randomized, open-label, phase 3 study included 361 patients. In both HbA1c subgroups (patients with baseline HbA1c ≤8.5% or>8.5%), a statistically significantly greater reduction in HbA1c was observed in dulaglutide-treated patients com...
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Impaired β-cell function and decreased insulin sensitivity in subjects with normal oral glucose tolerance but isolated high glycosylated hemoglobin.
Impaired β-cell function and decreased insulin sensitivity in subjects with normal oral glucose tolerance but isolated high glycosylated hemoglobin. Endocr J. 2017 Sep 13;: Authors: Fu Q, Sun M, Wang Z, He W, Duan Y, Yang T Abstract The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According to the ADA criteria of HbA1c cut-off point (5.7%...
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a single-institutional experience in Japan.
This study aimed to evaluate the clinical, cytological, and pathological findings of 54 cases of NIFTP from a single center in Japan, and compare them with those in the western countries. There were no significant differences in age, sex, or tumor size between patients with NIFTP and those with invasive encapsulated follicular variant -PTC. Ultrasound investigation showed a high suspicion lesion in NIFTP and invasive encapsulated follicular variant -PTC in 6.5% and 44.1%, respectively (p
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Irisin is a biomarker for metabolic syndrome in prepubertal children.
Authors: Suk Shim Y, Jae Kang M, Yang S, Tae Hwang I Abstract The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared t...
Source: Endocrine Journal - September 16, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of treatment with epoprostenol and endothelin receptor antagonists on the development of thyrotoxicosis in patients with pulmonary arterial hypertension.
Authors: Satoh M, Aso K, Nakayama T, Saji T Abstract Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HPAH who had been diagnosed with PAH before the age of 20 years. Thyrotoxicosis was detected in 12 of the 59 patients (6 patients with Graves' disease, 3 with hashitoxicosis, and 3 with silent thyroiditis) after the start of PAH treatment. The proporti...
Source: Endocrine Journal - September 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Free testosterone concentration is inversely associated with markers of liver fibrosis in men with type 2 diabetes mellitus.
Authors: Miyauchi S, Miyake T, Miyazaki M, Eguchi T, Niiya T, Yamamoto S, Senba H, Furukawa S, Matsuura B, Hiasa Y Abstract The association between serum testosterone level and liver fibrosis in patients with non-alcoholic fatty liver disease is unclear. To clarify this association, we investigated the relationship between serum free testosterone concentration and markers of liver fibrosis in men with type 2 diabetes mellitus but no obvious features of alcohol consumption. This retrospective observational cross-sectional study enrolled 248 men with type 2 diabetes mellitus. The FIB-4 index was measured as a marker ...
Source: Endocrine Journal - September 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The relationship between chronic kidney function and homeostasis model assessment of insulin resistance and beta cell function in Korean adults with or without type 2 diabetes mellitus.
In conclusion, insulin resistance was positively associated CKD with in Korean adults with or without T2DM. Beta cell function was positively associated CKD with in Korean adults without T2DM but not in Korean adults with T2DM. PMID: 28890482 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 13, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Developmental changes in hypothalamic SF-1, POMC, and ER α mRNA expression and their sensitivity to fasting in male and female rats.
In this study, we showed that hypothalamic SF-1 and ERα mRNA expression did not change during the neonatal to pre-pubertal period (from postnatal day 10 to 30), and there were no significant differences in the hypothalamic mRNA expression levels of these molecules between males and females at any examined age. On the other hand, hypothalamic POMC mRNA expression and the serum estradiol (E2) level increased during development in both males and females. Significant positive correlations were detected between the serum E2 level and hypothalamic POMC mRNA expression in both males and females. Hypothalamic ERα and P...
Source: Endocrine Journal - September 10, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

A case of metastatic follicular thyroid carcinoma complicated with Graves' disease after total thyroidectomy.
Authors: Aoyama M, Takizawa H, Tsuboi M, Nakagawa Y, Tangoku A Abstract Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) ther...
Source: Endocrine Journal - September 10, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Fine-needle aspiration cytology for medullary thyroid carcinoma: a single institutional experience in Japan.
Authors: Suzuki A, Hirokawa M, Takada N, Higuchi M, Ito A, Yamao N, Hayashi T, Kuma S, Miyauchi A Abstract Many cytological studies on medullary thyroid carcinoma (MTC) have been reported; however, such studies in large series of patients with MTC have not been performed. We investigated MTC at a single institution in Japan using fine-needle aspiration cytology (FNAC), and aimed to establish a preoperative diagnostic algorithm for MTC. FNAC was performed in 119 of 149 patients with nodules (79.9%) who ultimately underwent surgical resection. Moreover, hereditary MTC was diagnosed preoperatively in 22 nodules that d...
Source: Endocrine Journal - September 10, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Impact of fatty liver disease and metabolic syndrome on incident type 2 diabetes; a population based cohort study.
Authors: Mitsuhashi K, Hashimoto Y, Hamaguchi M, Obora A, Kojima T, Fukuda T, Fukui M Abstract Fatty liver disease and metabolic syndrome (MetS) are both shown to increase the risk of type 2 diabetes. The aim of this study was to investigate the combined effect of fatty liver and MetS on incident diabetes. In this cohort study of 17,810 participants, fatty liver was diagnosed by abdominal ultrasonography and MetS was defined by a joint interim statement. We divided the participants into four groups according to the presence of fatty liver and/or MetS. Type 2 diabetes was defined as HbA1c ≥6.5%, fasting plasma gl...
Source: Endocrine Journal - September 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Mild thyroid peroxidase deficiency caused by TPO mutations with residual activity: Correlation between clinical phenotypes and enzymatic activity.
In conclusion, we report that TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T3 to T4 molar ratio, and high serum thyroglobulin levels. Our findings illuminate the hitherto under-recognized correlation between clinical phenotypes and residual enzymatic activity among patients with TPO deficiency. PMID: 28867693 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules.
Authors: Wu W, Gong X, Zhou Q, Chen X, Chen X, Shi B Abstract The aim of this study was to define the effectiveness and safety of ultrasound(US)-guided percutaneous microwave ablation(MWA) for benign thyroid nodules with one session treatment. A total 121 benign thyroid nodules in 100 euthyroid patients underwent MWA in one medical center between August 2014 and December 2015. MWA was performed with an internally cooled antenna under local anesthesia. The volume of the nodule, cosmetic score and symptom score were compared before and after the procedure. The volume reduction rate(VRR) was also evaluated. The side e...
Source: Endocrine Journal - September 2, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well-differentiated thyroid cancer cells.
Authors: Sawa A, Chiba T, Ishii J, Yamamoto H, Hara H, Kamma H Abstract Well-differentiated thyroid carcinomas have driver mutations involving growth factor receptor-tyrosine kinases (RTKs) or their intracellular signaling pathway, that is, the mitogen-activated protein kinase (MAPK) pathway. Sorafenib is a multikinase inhibitor of RTKs and the MAPK pathway and has recently been used for the treatment of unresectable well-differentiated thyroid carcinoma. In normal thyroid follicular cells, stimulation of the thyroid-stimulating hormone (TSH) receptor activates the cyclic adenosine monophosphate (cAMP) pathway and ...
Source: Endocrine Journal - September 2, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

B-type natriuretic peptide and renal function in Japanese patients with type 2 diabetes mellitus: The Dogo Study.
This study included 671 Japanese patients with type 2 diabetes mellitus. BNP levels were divided at quartile points on the basis of the distribution. We used four outcomes regarding the renal function: 1) chronic kidney disease (CKD): estimated glomerular filtration rate (eGFR)
Source: Endocrine Journal - September 2, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of TPOAb.
In conclusion, TPO rs2071400 and rs2071403 polymorphisms were associated with the development of HD and GD, but not with the prognosis. Moreover, TPO rs2071400 and rs2048722 polymorphisms were associated with the serum levels of TPOAb. PMID: 28845025 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 30, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Marked recovery from glucotoxicity of β-cell function after medical nutrition therapy without pharmacotherapy in type 2 diabetic outpatients with extreme hyperglycemia: a pilot retrospective study.
Marked recovery from glucotoxicity of β-cell function after medical nutrition therapy without pharmacotherapy in type 2 diabetic outpatients with extreme hyperglycemia: a pilot retrospective study. Endocr J. 2017 Aug 25;: Authors: Takahara M, Shiraiwa T, Katakami N, Matsuoka TA, Shimomura I Abstract We investigated whether glucotoxicity of β-cell function could be eliminated after medical nutrition therapy (MNT) without forced correction of hyperglycemia by anti-diabetic medications including exogenous insulin administration. We analyzed newly diagnosed type 2 diabetic outpatients with hemogl...
Source: Endocrine Journal - August 30, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Rasd1 is an estrogen-responsive immediate early gene and modulates expression of late genes in rat anterior pituitary cells.
Authors: Wang L, Mitsui T, Ishida M, Izawa M, Arita J Abstract Dexamethasone-induced Ras-related protein 1 (Rasd1) is a member of the Ras superfamily of monomeric G proteins that have a regulatory function in signal transduction. Here we investigated the role of Rasd1 in regulating estrogen-induced gene expression in primary cultures of rat anterior pituitary cells. Rasd1 mRNA expression in anterior pituitary cells decreased after treatment with forskolin or serum and increased after treatment with 17β-estradiol (E2). Increases in Rasd1 mRNA expression occurred as early as 0.5 h after E2 treatment, peaked at 1...
Source: Endocrine Journal - August 26, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
In this study, we further investigated the pathway mediating IGFBP-5 nuclear import after it retro-translocation. Importin-α5 was identified as an IGFBP-5-interacting protein with a yeast two-hybrid system, and its interaction with IGFBP-5 was further confirmed by GST pull down and co-immunoprecipitation. Binding affinity of IGFBP-5 and importins were determined by surface plasmon resonance (IGFBP-5/importin-β: KD=2.44e-7, IGFBP-5/importin-α5: KD=3.4e-7). Blocking the importin-α5/importin-β nuclear import pathway using SiRNA or dominant negative impotin-β dramatically inhibited IGFBP-5-EGFP...
Source: Endocrine Journal - August 26, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Pitfalls in early biochemical evaluation after transsphenoidal surgery in patients with acromegaly.
In conclusion, the long-term results can be reliably predicted by the remission criteria early after surgery in most patients with acromegaly. For the accurate evaluation within a year after surgery, however, influence of preoperative treatment with SSA, delayed normalization of IGF-1, and poor GH suppression due to low insulin resistance must be considered, particularly in women. PMID: 28835593 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 26, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of ovarian hormones on GPR120 mRNA expression in mouse pituitary gonadotrophs.
Authors: Moriyama R, Ueda K, Deura C Abstract GPR120 is a G-protein-coupled receptor that is activated by long-chain fatty acids. In our previous study, GPR120 expression was detected in gonadotrophs of the mouse anterior pituitary gland. It is well known that the function of anterior pituitary cells is largely under the influence of circulating sex steroids. Thus, in the present study, we investigated the modulatory roles of the ovarian hormones, estrogen (E2) and progesterone (P), on the expression levels of GPR120 mRNA in mouse pituitary glands. GPR120 mRNA expression levels in the pituitary gland were increased...
Source: Endocrine Journal - August 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review].
Authors: Takayama KI Abstract Hormonal alterations with aging contribute to the pathogenesis of several diseases. Androgens mediate their effects predominantly through binding to the androgen receptor (AR), a member of the ligand-dependent nuclear receptor superfamily. By androgen treatment, AR is recruited to specific genomic loci dependent on tissue specific pioneer factors to regulate target gene expression. Recent studies have revealed the epigenetic modulation by AR-associated histone modifiers and the roles of non-coding RNAs in AR signaling. Androgens are male sex hormone to induce differentiation of the mal...
Source: Endocrine Journal - August 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of canagliflozin on circulating active GLP-1 levels in patients with type 2 diabetes: a randomized trial.
In conclusions, canagliflozin-administration before meals decreased PG and serum insulin, and increased plasma active GLP-1 levels in patients with type 2 diabetes. Canagliflozin did not greatly influence plasma active GIP levels. PMID: 28824041 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Comparison of tofogliflozin 20 mg and ipragliflozin 50 mg used together with insulin glargine 300 U/ml using continuous glucose monitoring (CGM): A randomized crossover study.
Authors: Takeishi S, Tsuboi H, Takekoshi S Abstract To investigate whether sodium glucose co-transporter 2 inhibitors (SGLT2i), tofogliflozin or ipragliflozin, achieve optimal glycemic variability, when used together with insulin glargine 300 U/mL (Glargine 300). Thirty patients with type 2 diabetes were randomly allocated to 2 groups. For the first group: After admission, tofogliflozin 20 mg was administered; Fasting plasma glucose (FPG) levels were titrated using an algorithm and stabilized at 80 mg/dL level with Glargine 300 for 5 days; Next, glucose levels were continuously monitored for 2 days using continuous...
Source: Endocrine Journal - August 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Protective effects of Lycium barbarum polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice.
Authors: Shi GJ, Zheng J, Wu J, Qiao HQ, Chang Q, Niu Y, Sun T, Li YX, Yu JQ Abstract Diabetes-associated male sexual dysfunction and fertility impairments are both common clinical complications with limited therapeutic options; hence it seriously affects the quality of life of the patients, in particular, the patients of reproductive age. Lycium barbarum polysaccharide (LBP) has long being believed to maintain and to promote reproductive functions in the traditional medical practice in China. The current study was to investigate if LBP may contribute to recovery of male sexual dysfunction and fertility impairments...
Source: Endocrine Journal - August 11, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine.
This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series. On multivariate comparison, the Japanese pediatric PTC was cha...
Source: Endocrine Journal - August 11, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Papillary thyroid carcinoma with desmoid-type fibromatosis: A clinical, pathological, and immunohistochemical study of 14 cases.
This report aims to describe the clinical, pathological, and immunohistochemical findings in 14 cases of PTC-DTF and to clarify the diagnostic significance of the variant. The patients included 9 women and 5 men, with a mean age of 49.3 years. PTCs with focal DTF components and with extensive DTF components included 7 cases each. No significant differences were noted in terms of age, gender, and serum thyroglobulin levels between extensive and focal DTF cases. On aspiration cytology, 12 cases were reported as suspicious for malignancy or malignant, and schwannoma or fibroma was suggested in 1 case each. The DTF components ...
Source: Endocrine Journal - August 11, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Latent class analysis suggests four classes of persons with type 2 diabetes mellitus based on complications and comorbidities in Tianjin, China: a cross-sectional analysis.
In this study, 5,500 patients with type 2 diabetes mellitus from ten hospitals in Tianjin, China were selected, and the response rate was 96.2%. Latent Class Analysis was used to cluster patients. After compared the baseline characteristics, multinomial logistic regression was applied. Patients with type 2 diabetes mellitus were classified into four classes. In the univariate analysis, all variables were significant (p
Source: Endocrine Journal - August 8, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases.
In conclusion, the prevalence of TgAb was higher than that of TPOAb in patients with Hashimoto's thyroiditis and painless thyroiditis using commercially available kits. We suggest that TgAb immunoassay is the first choice of screening test for thyroid autoimmune abnormalities in Japan. PMID: 28768936 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Definitive surgical treatment of osteomalacia induced by skull base tumor and determination of the half-life of serum fibroblast growth factor 23.
Authors: Hana T, Tanaka S, Nakatomi H, Shojima M, Fukumoto S, Ikemura M, Saito N Abstract Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome often associated with fibroblast growth factor 23 (FGF23)-producing tumors such as phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT) affecting the bone and soft tissue. We experienced a patient with progressive bone and muscle pain due to FGF23-related TIO. Venous sampling had strongly suggested the anterior skull base as a source of FGF23, which led to the discovery of a small tumor in the ethmoid sinus extending intracranially. Radical ...
Source: Endocrine Journal - August 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Next generation sequencing-based mutation screening of 86 patients with idiopathic short stature.
Authors: Hattori A, Katoh-Fukui Y, Nakamura A, Matsubara K, Kamimaki T, Tanaka H, Dateki S, Adachi M, Muroya K, Yoshida S, Ida S, Mitani M, Nagasaki K, Ogata T, Suzuki E, Hata K, Nakabayashi K, Matsubara Y, Narumi S, Tanaka T, Fukami M Abstract Although mutations in ACAN, FGFR3, NPR2, and SHOX typically lead to skeletal dysplasia, and mutations in GHRHR, GH1, GHR, STAT5B, IGF1, IGFALS, and IGF1R usually underlie hormonal defects of the growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis, such mutations have also been identified in patients with idiopathic short stature (ISS). Of these, SHOX abnormalities a...
Source: Endocrine Journal - August 6, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Careful readings for a flash glucose monitoring system in nondiabetic Japanese subjects: individual differences and discrepancy in glucose concentrarion after glucose loading [Rapid Communication].
Authors: Sekido K, Sekido T, Kaneko A, Hosokawa M, Sato A, Sato Y, Yamazaki M, Komatsu M Abstract The FreeStyle Libre Flash Glucose Monitoring System (FGM), which can continuously measure glucose concentration in the interstitial fluid glucose (FGM-ISFG), has been in clinical use worldwide. However, it is not clear how accurately FGM-ISFG reflects plasma glucose concentration (PG). In the present study, we examined the clinical utility of FGM by oral glucose tolerance test (OGTT). In eight healthy volunteers (3 males; mean age, 41.8 y) wearing FGM sensors for 14 days, OGTT was performed during days 1-7 and days 8-1...
Source: Endocrine Journal - July 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research