Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide.
This study aimed to clarify the clinical factors, which may affect efficacy and safety of the diazoxide treatment. We retrospectively evaluated the medical records of 20 patients with insulinoma including 4 malignant cases. The patients were divided into two groups according to the presence or absence of favorable outcomes or adverse effects, and the clinical features of both groups were compared. Diazoxide was effective and ineffective in each 9 patients, respectively. In other 2 cases, the efficacy could not be determined. In the effective group, all patients had benign insulinoma. Additionally, the tumor size determined...
Source: Endocrine Journal - December 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Risk factors for postoperative cardiovascular morbidity after pheochromocytoma surgery: a large single center retrospective analysis.
Authors: Bai S, Yao Z, Zhu X, Li Z, Jiang Y, Wang R, Wen N Abstract Surgical resection is the primary treatment strategy for pheochromocytoma; however, it carries a high risk of morbidity and mortality, especially with respect to cardiovascular complications, which is the most common kinds of morbidity. The risk factors for morbidity remain unclear and require further exploration, moreover no studies focus on risk factors for cardiovascular morbidity. Herein we identified the risk factors for cardiovascular morbidity after pheochromocytoma surgery in Chinese patients. We retrospectively reviewed 262 patients who un...
Source: Endocrine Journal - December 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation.
Authors: Tamura Y Abstract Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. In addition, studies using 2-step hyperinsulinemic euglycemic clamp with a glucose tracer may clarify how tissue-specific ...
Source: Endocrine Journal - December 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Intraoperative rapid aspiration cytological method for parathyroid glands identification and protection.
In this study, 172 suspicious parathyroid glands were observed. According to frozen pathology outcome, the accuracy, sensitivity and specificity of clinician eyeballing were calculated as 63.3%, 100%, and 13.9%. Kappa test showed poor consistency (kappa = 0.156), AUC area was 0.569 ± 0.045, 95%CI = (0.480-0.658), p = 0.123. For cytological and PTH detection, the accuracy, sensitivity and specificity were 91.7% vs. 92.3%, 93.6% vs. 93.8% and 89.0% vs. 90.3%. Kappa value was 0.829 vs. 0.842, indicating good consistency. AUC area was 0.908 ± 0.027 vs. 0.918 ± 0.025, 95%CI = (0.856-0.960) vs. (0.869-0.966), p
Source: Endocrine Journal - December 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.
Authors: Nagao S, Iwata N, Soejima Y, Takiguchi T, Aokage T, Kozato Y, Nakano Y, Nada T, Hasegawa T, Otsuka F Abstract A functional link between clock gene expression and ovarian steroidogenesis was studied using human granulosa KGN cells. Similarities between changes in the mRNA and protein expression levels of Bmal1 and Clock and those of Per2 and Cry1 were found in KGN cells after treatment with forskolin. Among the interrelationships between the expression levels of clock and steroidogenic factors, Clock mRNA had a strongly positive correlation with P450arom and a negative correlation with 3βHSD. Knockdown...
Source: Endocrine Journal - December 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Optimal needle size for thyroid fine needle aspiration cytology.
Authors: Tanaka A, Hirokawa M, Higuchi M, Kanematsu R, Suzuki A, Kuma S, Hayashi T, Kudo T, Miyauchi A Abstract Concerning the needle size for thyroid fine needle aspiration cytology (FNAC), 25-27-gauge needles are generally used in Western countries. However, in Japan, the use of larger needles (21-22-gauge needles) is common. The aim of our study was to determine the optimal needle size for thyroid FNAC. We performed ultrasound-guided FNAC for 200 thyroid nodules in 200 patients using two different-sized needles (22 and 25 gauge). For each nodule, two passes with the different-sized needles were performed. The or...
Source: Endocrine Journal - November 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of a diet with or without physical activity on angiopoietin-like protein 8 concentrations in overweight/obese patients with newly diagnosed type 2 diabetes: a randomized controlled trial.
Authors: Hu H, Yuan G, Wang X, Sun J, Gao Z, Zhou T, Yin W, Cai R, Ye X, Wang Z Abstract Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated the effect of lifestyle intervention on ANGPTL8 concentrations. 384 obese/overweight adults with newly diagnosed T2D were randomly assigned (1:1:1) to diet (n = 128), diet + activity (n = 128) or usual care (contro...
Source: Endocrine Journal - November 16, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Premature ovarian insufficiency may be associated with the mutations in mitochondrial tRNA genes.
Authors: Ding Y, Xia BH, Zhuo GC, Zhang CJ, Leng JH Abstract Premature ovarian insufficiency (POI) is a common endocrine disorder featured by the triad constituting of amenorrhea for at least four months, to date, the molecular pathogenesis of POI is largely undetermined. Despite several investigations have reported an increase in reactive oxygen species (ROS) content in idiopathic POI, the role of mitochondrial DNA (mtDNA) mutations/variants in the progression of POI has not been widely investigated. The current study aimed to explore the association between mt-tRNA mutations/variants and POI; we first used the PC...
Source: Endocrine Journal - November 9, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis.
Authors: Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J Abstract We conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG...
Source: Endocrine Journal - November 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results).
Authors: Tabuchi H, Maegawa H, Tobe K, Nakamura I, Uno S Abstract This subgroup analysis of STELLA-LONG TERM, an ongoing 3-year post-marketing surveillance study on the long-term efficacy and safety of ipragliflozin, assessed the effect of ipragliflozin on liver function in type 2 diabetes mellitus (T2DM) patients. Patients were divided according to baseline liver function (normal [male: ALT ≤30, female: ALT ≤20], abnormal [male: ALT ≥31, female: ALT ≥21]). We evaluated changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (γ-GTP), alkaline phosphat...
Source: Endocrine Journal - November 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Association of the muscle/fat mass ratio with insulin resistance in gestational diabetes mellitus.
This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for initial education and glycemic control were enrolled in a prospective observational study. Insulin resistance was evaluated by measuring the ISI and body composition was assessed by bioelectrical impedance analysis. The subjects were aged 34.4 ± 4.8 years (mean ± SD) and their body mass index (BMI) b...
Source: Endocrine Journal - November 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
Authors: Tsuchiya S, Sawada S, Takeda K, Takahashi K, Nakajima T, Kohata M, Kurosawa S, Satake C, Imai J, Kikuchi K, Aiba S, Katagiri H Abstract Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes. We herein report a 15-year-old obese patient with the apolipoprotein E4/2 phenotype, in whom eruptive xanthomas lead to a diagnosis of soft-drink diabetic ketosis. He developed multiple asymptomatic yellowish papules on the auricles, back, buttocks and the extensor surface...
Source: Endocrine Journal - November 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells.
Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells. Endocr J. 2018 Oct 26;: Authors: Yang L, Jeong KW Abstract The human homologue of flightless-I (FLII) belong to the gelsolin protein family and contain a gelsolin-like domain at the C-terminus and a leucine-rich repeat (LRR) domain at the N-terminus. FLII regulates estrogen receptor alpha (ERα) and glucocorticoid receptor (GR)-mediated transcription by direct interaction through different domains, suggestive of its potential role in the crosstalk between the ER&a...
Source: Endocrine Journal - October 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Cohort study exploring the effect of lenvatinib on differentiated thyroid cancer.
This study is designed to estimate the 95% confidence intervals of the 1-year and 2-year survival rates with a two-sided width of less than 10%. Secondary endpoints will be the time to treatment failure, time to strategy failure, progression-free survival time with clinical progressive disease, response rate, quality of life, safety, and patient reports. The ultimate goal is to obtain information for developing evidence-based guidelines for treatment of DTC, including recommendations on patient selection, dosages, and duration of treatment. This study has been registered with the UMIN Clinical Trials Registry (UMIN00002224...
Source: Endocrine Journal - October 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Erratum.
Authors: PMID: 30369532 [PubMed - in process] (Source: Endocrine Journal)
Source: Endocrine Journal - October 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients.
Authors: Islam MS, Namba N, Ohata Y, Fujiwara M, Nakano C, Takeyari S, Miyata K, Nakano Y, Yamamoto K, Nakayama H, Kitaoka T, Kubota T, Ozono K Abstract Monocarboxylate transporter 8 (MCT8) facilitates T3 uptake into cells. Mutations in MCT8 lead to Allan-Herndon-Dudley syndrome (AHDS), which is characterized by severe psychomotor retardation and abnormal thyroid hormone profile. Nine uncharacterized MCT8 mutations in Japanese patients with severe neurocognitive impairment and elevated serum T3 levels were studied regarding the transport of T3. Human MCT8 (hMCT8) function was studied in wild-type (WT) or mutant hMC...
Source: Endocrine Journal - October 30, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Estrogen signaling increases nuclear receptor subfamily 4 group A member 1 expression and energy production in skeletal muscle cells.
Authors: Nagai S, Ikeda K, Horie-Inoue K, Takeda S, Inoue S Abstract Estrogen deficiency has been known to associate with musculoskeletal diseases in women, based on the clinical observations of frequent susceptibility to osteoporosis and sarcopenia among postmenopausal women. In skeletal muscles, estrogen has been assumed to play physiological roles in maintaining muscle mass and strength, although its precise molecular mechanism remains to be elucidated. We have previously shown that estrogen regulates energy metabolism through the downregulation of mitochondrial uncoupling protein 3 (UCP3) in skeletal muscles, w...
Source: Endocrine Journal - October 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.
In conclusion, Ffar1 expression is markedly down-regulated under diabetic conditions which is accompanied by decreased expression of Pdx1. Furthermore, it is likely that Pdx1 is a regulator of Ffar1 expression in β-cells. PMID: 30333365 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - October 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Different daily glycemic profiles after switching from once-daily alogliptin plus twice-daily metformin to their once-daily fixed-dose combination in Japanese type 2 diabetic patients.
Authors: Takahara M, Shiraiwa T, Katakami N, Maeno Y, Yamamoto K, Shiraiwa Y, Yoshida Y, Matsuoka TA, Shimomura I Abstract The aim of this study was to investigate whether daily glycemic profiles and treatment satisfaction would be changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily in type 2 diabetic patients. Twenty adult Japanese type 2 diabetic patients in whom once-daily 25-mg alogliptin plus twice-daily 250-mg metformin were switched to the fixed-dose combination of 25-mg alogliptin and 500...
Source: Endocrine Journal - October 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Lower serum total bilirubin concentration is associated with higher prevalence of gestational diabetes mellitus in Japanese pregnant women.
Authors: Nishimura T, Tanaka M, Saisho Y, Miyakoshi K, Tanaka M, Itoh H Abstract We aimed to clarify the pathophysiological significance of total bilirubin (TB) in gestational diabetes mellitus (GDM). This was a cross-sectional study that included 616 pregnant Japanese women (368 normal glucose tolerance [NGT] and 248 GDM). Serum TB concentration, homeostasis model assessment of insulin resistance (HOMA-IR), and other clinical parameters were compared in NGT and GDM women. TB concentration was also compared according to the number of abnormal OGTT values. Logistic regression analysis was used to evaluate the associ...
Source: Endocrine Journal - October 13, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Impact of the modification of the diagnostic criteria in the 2017 Bethesda System for Reporting Thyroid Cytopathology: a report of a single institution in Japan.
In conclusion, TBSRTC 2017 only caused minor changes in the incidence of each diagnostic category. TBSRTC 2017 was revised to avoid false positives owing to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) that account for>10% of papillary thyroid carcinomas; however, it is not necessary in low frequency NIFTP institutes or countries. In Japan, we propose active surveillance as an accepted option for clinically managing AUS/FLUS, FN/SFN, SFM, or malignant nodules having favorable benign clinical findings or being part of the low-risk group. PMID: 30282887 [PubMed - as supplied by ...
Source: Endocrine Journal - October 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity.
Authors: Okada-Iwabu M, Iwabu M, Yamauchi T, Kadowaki T Abstract Plasma adiponectin levels and expression of its receptors, AdipoRs are decreased in obesity, which cause insulin resistance and diabetes. AdipoR-deficient mice exhibit insulin resistance and impaired glucose tolerance. Moreover, newly identified AdipoR agonists not only improve insulin resistance but prolong lifespan shortened by obesity via AdipoR. Furthermore, efforts to promote structure-based drug discovery research at our laboratory have led to the first ever successful crystallization of AdipoR as well as to clarification of their structures. St...
Source: Endocrine Journal - October 6, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Obituary - Professor Kei-ichiro Maeda.
Authors: Tsukamura H PMID: 30259885 [PubMed - in process] (Source: Endocrine Journal)
Source: Endocrine Journal - September 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Erratum.
Authors: PMID: 30259886 [PubMed - in process] (Source: Endocrine Journal)
Source: Endocrine Journal - September 29, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.
Authors: Yamamuro T, Inoue K, Nagai Y, Azuma D, Yamamoto A, Hara K, Kohara M, Iwata T, Nakatsuka S, Morii E, Yamamoto T Abstract Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical exami...
Source: Endocrine Journal - September 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Rescue of the fetal damage associated with high intrauterine pressure by 17 β-estradiol injection in ovariectomized progesterone-treated pregnant mice.
Rescue of the fetal damage associated with high intrauterine pressure by 17β-estradiol injection in ovariectomized progesterone-treated pregnant mice. Endocr J. 2018 Sep 19;: Authors: Tadotsu D, Kawate N, Tamada H Abstract The present study examined the effects of progesterone (P) and 17β-estradiol (E2) on fetal damage and intrauterine pressure in ovariectomized pregnant mice. The mice were ovariectomized on gestational day (GD) 9 (copulation plug = GD 0), and daily subcutaneous injection of various doses of P (2, 3 or 4 mg) or 4 mg P plus E2 (0.05 or 0.1 μg) was given thereafter. Although...
Source: Endocrine Journal - September 22, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Spontaneous virilization around puberty in NR5A1-related 46,XY sex reversal: additional case and a literature review.
Authors: Adachi M, Hasegawa T, Tanaka Y, Asakura Y, Hanakawa J, Muroya K Abstract A heterozygous NR5A1 mutation is one of the most frequent causes of 46,XY DSD (disorders of sex development). We here reported a NR5A1-related 46,XY DSD patient, who first received endocrinological attention at 10 years of age for clitoromegaly. The patient had been reared as a girl, and no signs of virilization had been detected before. On examination, her clitoris was 35 mm long and 10 mm wide, with Tanner 3° pubic hair. Urogenital sinus and labial fusion was absent, while her uterus was found to be severely hypoplastic. Her bas...
Source: Endocrine Journal - September 19, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of diet control on puberty onset and immunoreactivity of kisspeptin and neurokinin B in female rats.
We examined kisspeptin/Kiss1-receptor and neurokinin B/neurokinin3-receptor immunoreactivity (IR) in the arcuate nucleus of the pups. The onset of puberty in the high-fat group was significantly earlier than the control group. At the onset of puberty, the densities of kisspeptin and neurokinin B IR cells were significantly higher in the high-fat diet group than in the control group; however, the densities of KISS1 and neurokinin 3-receptor IR cells did not differ between the two groups. At PND 85, the density of kisspeptin and neurokinin B IR cells did not differ between control and high fat group. The density of densities...
Source: Endocrine Journal - September 19, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Utility of monoclonal PAX8 antibody for distinguishing intrathyroid thymic carcinoma from follicular cell-derived thyroid carcinoma.
Authors: Suzuki A, Hirokawa M, Takada N, Higuchi M, Tanaka A, Hayashi T, Kuma S, Miyauchi A Abstract Follicular cell-derived thyroid carcinomas, including thyroid squamous cell carcinomas (SCCs) and anaplastic carcinomas, are immunoreactive for paired-box gene 8 (PAX8), while non-follicular cell-derived thyroid carcinomas stain negative for the PAX8 antibody. Intrathyroid thymic carcinoma (ITTC) arising from the intrathyroidal ectopic thymus exhibits moderate-to-strong nuclear reactivity for polyclonal PAX8. This is difficult to understand given that PAX8 is not associated with embryonic thymic development. We aime...
Source: Endocrine Journal - September 15, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Vanishing of ruptured adrenal mass with takotsubo cardiomyopathy.
Authors: Takeshita Y, Teramura C, Takamura T Abstract A 45-year-old male suddenly experienced left-flank abdominal pain. Echocardiography revealed akinesis of the 'takotsubo cardiomyopathy' type. He experienced a sudden haemodynamic collapse (blood pressure, 324/154 mmHg; pulse rate, 180 beats/min) during emergency cardiac catheterisation. An abdominal computed tomography (CT) revealed expansion of a soft tissue mass 64 × 33 mm in dimension in the left adrenal region, with accumulation of fluid surrounding the left pararenal space. Three days after the attack, his urinary catecholamine concentrations were sli...
Source: Endocrine Journal - September 12, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Visceral adipose tissue increases shortly after the cessation of GH therapy in adults with Prader-Willi syndrome.
In conclusion, discontinuation of GH therapy caused rapid increases in visceral adipose tissue and LDL cholesterol levels. These findings indicate that continuation of GH therapy may be a therapeutic option to maintain body composition; however, further studies regarding the long-term benefits and adverse effects of GH therapy in adults with PWS are required. PMID: 30185718 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Pharmacokinetics of insulin disappearance after massive overdosing.
In conclusion, the t1/2 for insulin was elongated 2 to 7 times after massive overdosing, explaining why glucose supplementation is needed for long periods in these cases. PMID: 30185719 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - September 8, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Sex hormones play roles in determining musk composition during the early stages of musk secretion by musk deer (Moschus berezovskii).
In this study, we analyzed the dynamic changes in musk components from June to April of the following year. The result showed that musk morphological character, water content, total ion chromatographic pattern, and composition undergo seasonal change. Luminescence immunoassay and radioimmunoassay analyses were performed to determine corresponding fecal hormone levels. The results showed that testosterone, estrogen, and cortisol levels in feces change on a seasonal basis, and are significantly higher in June than in other months (p
Source: Endocrine Journal - September 5, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year's bone mineral density change.
In conclusion, thyroxine suppressive therapy in postmenopausal women had significant reduction in nodule volume at initial 2 years of treatment, especially in volume larger than 2.6 mL. Prolonged thyroxine treatment did not benefit nodular size reduction and may affect BMD minimally in postmenopausal women. PMID: 30158361 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Glucocorticoid resistance syndrome caused by a novel NR3C1 point mutation.
In conclusion, in patients with clinically unexpected ACTH-dependent hypercortisolemia, primary glucocorticoid resistance (GRS) should be considered. PMID: 30158362 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 31, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effect of anti-TNF therapy on thyroid function in patients with inflammatory bowel disease.
In conclusion, patients with IBD showed a quite high percentage of thyroid autoimmunity. After treatment with anti-TNF, FT4 levels were found to be reduced, while no changes in TSH, T3 levels and thyroid auto-antibodies were noted. PMID: 30135331 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 24, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Comment on: "Derivation of thyroid lymphoepithelial cysts from follicular cells".
Comment on: "Derivation of thyroid lymphoepithelial cysts from follicular cells". Endocr J. 2018 Aug 10;: Authors: Hirokawa M, Suzuki A, Miyauchi A PMID: 30101807 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Impact of preoperative pasireotide therapy on invasive octreotide-resistant acromegaly.
Authors: Yamamoto R, Robert Shima K, Igawa H, Kaikoi Y, Sasagawa Y, Hayashi Y, Inoshita N, Fukuoka H, Takahashi Y, Takamura T Abstract A 43-year-old woman with an 8-year history of diabetes, hypertension, and dyslipidemia presented with amenorrhea and convulsion. Her MRI scan revealed a 3.5-cm T2-hyperintense pituitary macroadenoma with suprasellar extension to the frontal lobe and bilateral cavernous sinus invasion. Her serum levels of GH and insulin-like growth factor-I (IGF-I) were elevated to 9.08 ng/mL (normal range:
Source: Endocrine Journal - August 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

A case of pheochromocytoma with a marked decrease in catecholamine levels after rupture in which a good outcome was achieved by elective surgery.
Authors: Murai N, Azami T, Iida T, Mikura K, Imai H, Kaji M, Hashizume M, Kigawa Y, Koizumi G, Tadokoro R, Endo K, Iizaka T, Saiki R, Otsuka F, Norose T, Yamagishi M, Kurokawa I, Oike N, Sasaki H, Nagasaka S Abstract Changes in imaging findings and hormone levels before and after pheochromocytoma rupture, as well as detailed histopathology of resected tumors, have rarely been reported. A 52-year-old woman developed hypertension and diabetes mellitus in 2014, but despite treatment with antihypertensive and hypoglycemic drugs, good control was not achieved. On April 2, 2016, the patient started to have headaches and ...
Source: Endocrine Journal - August 7, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Heterogeneous nature of diabetes in a family with a gain-of-function mutation in the ATP-binding cassette subfamily C member 8 (ABCC8) gene.
Authors: Shima KR, Usuda R, Futatani T, Akahori H, Kaneko S, Yorifuji T, Takamura T Abstract Gain-of-function ATP-binding cassette subfamily C member 8 (ABCC8) mutations are known to cause neonatal diabetes mellitus and maturity-onset diabetes in the young. However, the intrafamilial heterogeneous nature of diabetes caused by the ABCC8 mutation is not fully understood to date. To clarify the intrafamilial heterogeneous nature of monogenetic diabetes, we conducted a case study on a family with ABCC8 mutations. We investigated eight family members, including a neonatal diabetes patient, based on metabolic features an...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Age-related change in thyroid-stimulating hormone: a cross-sectional study in healthy euthyroid population.
Authors: Chen J, Zhou W, Pan F, Cui W, Li M, Hu Y Abstract This cross-sectional study aimed to examine changes in thyroid-stimulating hormone (TSH) concentration over age in China and investigate relationship between TSH and risk factors for cardiovascular disease (CVD) among euthyroid subjects. TSH, free triiodothyronine (FT3), free thyroxine (FT4), blood lipid, and glucose were measured. 7,693 individuals were subdivided into different age groups. Associations between TSH and CVD risk factors [age, body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), triglycerides, low density lip...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Clinical relevance of low androgen to gastroesophageal reflux symptoms.
Authors: Harada K, Hanayama Y, Yasuda M, Hasegawa K, Obika M, Kataoka H, Itoshima K, Okada K, Otsuka F Abstract The aim of this study was to determine the relationships between free testosterone (FT) level and parameters including laboratory data and data from questionnaires and to determine symptoms leading to the detection of late onset hypogonadism (LOH). We retrospectively reviewed medical records of patients in whom serum FT was measured in our hospital. Aging Male Symptoms (AMS) score, self-rating depression scale (SDS) and frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) score were ...
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Unexpected high plasma xanthine oxidoreductase activity in female subjects with low levels of uric acid.
In conclusion, unexpected high plasma XOR activities were found in some female subjects with relatively low levels of uric acid. Measurement of plasma XOR activity may help to identify hypouricemic patients with a high risk for EIAKI. PMID: 30068899 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 4, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

The effectiveness of dapagliflozin for sleep-disordered breathing among Japanese patients with obesity and type 2 diabetes mellitus.
In conclusion, dapagliflozin might improve moderate to severe SDB but not mild SDB in Japanese patients with obesity and type 2 diabetes mellitus. PMID: 30047511 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - August 1, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.
Authors: Botelho IMB, Moura Neto A, Silva CA, Tambascia MA, Alegre SM, Zantut-Wittmann DE Abstract Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytok...
Source: Endocrine Journal - August 1, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Factors associated with treatment satisfaction in patients with type 2 diabetes mellitus using oral glucose-lowering agents: a cross-sectional study in urban districts in Japan.
Authors: Hayashi I, Watanabe N, Nakata S, Komatsu R, Motoda S, Fujita Y, Ishibashi C, Yamaguchi Baden M, Kimura T, Takahara M, Kozawa J, Imagawa A, Iwahashi H, Shimomura I Abstract Various oral glucose-lowering agents are available in Japan. Although the objective characteristics of these drugs are well described, little is known about treatment satisfaction by patients using these agents. The aim of this study was to assess treatment satisfaction of diabetic patients visiting diabetes clinics using the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and to determine the association of the DTSQ scores with var...
Source: Endocrine Journal - July 25, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Targeted next-generation sequencing of thirteen causative genes in Chinese patients with congenital hypothyroidism.
Authors: Long W, Lu G, Zhou W, Yang Y, Zhang B, Zhou H, Jiang L, Yu B Abstract To identify the spectrum and prevalence of thirteen causative genes mutations in congenital hypothyroidism (CH) patients, we collected blood samples and extracted genomic DNA of 106 CH patients, and designed a customized targeted next-generation sequencing panel containing 13 CH-causing genes to detect mutations. A total of 132 mutations were identified in 65.09% of patients (69/106) on the following nine genes: DUOX2, TG, TPO, TSHR, TTF1, TTF2, NKX2-5, PAX8 and GNAS. 69.70% (92/132) mutations related to thyroid dyshormonogenesis genes, ...
Source: Endocrine Journal - July 21, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

11-oxygenated C19 steroids as circulating androgens in women with polycystic ovary syndrome.
Authors: Yoshida T, Matsuzaki T, Miyado M, Saito K, Iwasa T, Matsubara Y, Ogata T, Irahara M, Fukami M Abstract 11-oxygenated C19 steroids (11oxC19s) are newly specified human androgens. Although median serum levels of 11oxC19 were reported to be higher in patients with polycystic ovary syndrome (PCOS) than in unaffected women, inter-individual variations in androgen levels among PCOS patients have poorly been investigated. Here, we quantified four 11oxC19s, i.e., 11-ketotestosterone (11KT), 11β-hydroxytestosterone (11OHT), 11β-hydroxyandrostenedione (11OHΔ4A), and 11-ketoandrostenedione (11KΔ...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Neutrophil-lymphocyte ratio correlates with limited joint mobility of hand in patients with type 2 diabetes.
Authors: Mineoka Y, Ishii M, Hashimoto Y, Nakamura N, Katsumi Y, Isono M, Fukui M Abstract Limited joint mobility (LJM) of hand, which is one of the complications of diabetic hand, is associated with diabetic micro- and macroangiopathy although the precise pathogenesis is not completely understood. Neutrophil-lymphocyte ratio (NLR), a simple and novel inflammatory marker, has been reported to have a predictive effect to some diabetic complications in recent years. However, it is not elucidated about the relationship between LJM of hand and NLR in patients with type 2 diabetes. We evaluated the relationships between...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of surgical treatment for acromegaly on knee MRI structural features.
This study was undertaken to analyze the effects of transsphenoidal surgery (TSS) on acromegalic arthropathy and elucidate whether knee MRI findings are reversible or irreversible. We analyzed 22 patients with acromegaly (63.7% females, median age 58 years) by knee MRI at diagnosis. Out of these 22 patients, 16 who underwent TSS (68.9% female, median age 58 years) were also subjected to knee MRI 2 months after TSS. As for X-ray undetectable findings, MRI detected synovial thickening, bone marrow lesion, ligament injury and meniscus injury in 22.7%, 22.7%, 4.7% and 59.1% of the patients, respectively. With respect to the 16...
Source: Endocrine Journal - July 18, 2018 Category: Endocrinology Tags: Endocr J Source Type: research