A case of adrenocortical adenoma harboring venous thrombus mimicking adrenal malignancy
We report a clinically interesting case of a 59-year-old female with adrenocortical adenoma harboring venous thrombus that mimicked adrenal malignancy. She was referred for evaluation of asymptomatic asymmetric lesions on both adrenal glands. Abdominal computed tomography and magnetic resonance imaging showed a 4.7-cm-diameter heterogenous lesion with peripheral enhancement in the right adrenal gland and a 2.0-cm-diameter homogenous lesion in the left adrenal gland. Adrenal scintigraphy with 131I-adosterol exhibited marked accumulation in the left lesion and slight accumulation in the middle inferior portion of the right l...
Source: Endocrine Journal - March 4, 2021 Category: Endocrinology Authors: Agena Suzuki Yuji Kamata Tomomi Taguchi Koji Takano Yuto Yamazaki Hironobu Sasano Masayoshi Shichiri Source Type: research

Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)- ‍a ‍population-based study
Conclusion, lower serum 25(OH)D level is associated with higher prevalence of MAFLD in general population. No relationship was found between serum 25(OH)D level and the severity of hepatic steatosis or fibrosis in MAFLD.PMID:33658438 | DOI:10.1507/endocrj.EJ20-0758 (Source: Endocrine Journal)
Source: Endocrine Journal - March 4, 2021 Category: Endocrinology Authors: Bo Wan Yuan Gao Yushan Zheng Ruanqin Chen Source Type: research

A case of adrenocortical adenoma harboring venous thrombus mimicking adrenal malignancy
We report a clinically interesting case of a 59-year-old female with adrenocortical adenoma harboring venous thrombus that mimicked adrenal malignancy. She was referred for evaluation of asymptomatic asymmetric lesions on both adrenal glands. Abdominal computed tomography and magnetic resonance imaging showed a 4.7-cm-diameter heterogenous lesion with peripheral enhancement in the right adrenal gland and a 2.0-cm-diameter homogenous lesion in the left adrenal gland. Adrenal scintigraphy with 131I-adosterol exhibited marked accumulation in the left lesion and slight accumulation in the middle inferior portion of the right l...
Source: Endocrine Journal - March 4, 2021 Category: Endocrinology Authors: Agena Suzuki Yuji Kamata Tomomi Taguchi Koji Takano Yuto Yamazaki Hironobu Sasano Masayoshi Shichiri Source Type: research

Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)- ‍a ‍population-based study
Conclusion, lower serum 25(OH)D level is associated with higher prevalence of MAFLD in general population. No relationship was found between serum 25(OH)D level and the severity of hepatic steatosis or fibrosis in MAFLD.PMID:33658438 | DOI:10.1507/endocrj.EJ20-0758 (Source: Endocrine Journal)
Source: Endocrine Journal - March 4, 2021 Category: Endocrinology Authors: Bo Wan Yuan Gao Yushan Zheng Ruanqin Chen Source Type: research

Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older
In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804-CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis.PMID:33642417 | DOI:10.1507/endocrj.EJ20-0519 (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Jiseon Lee Hye Won Woo Jihye Kim Min-Ho Shin InSong Koh Bo Youl Choi Mi Kyung Kim Source Type: research

Systematic review and meta-analysis: dipeptidyl peptidase-4 inhibitors and rheumatoid arthritis risk
Endocr J. 2021 Feb 26. doi: 10.1507/endocrj.EJ20-0647. Online ahead of print.ABSTRACTThis review evaluated the risk of rheumatoid arthritis in patients with type 2 diabetes treated with dipeptidyl peptidase-4 inhibitors (Dpp-4i). The MEDLINE (via PubMed), Embase, the Cochrane Library databases and web of science were used to search the effects of Dpp-4i on rheumatoid arthritis in patients with type 2 diabetes from inception to 7 September, 2020. We included studies that met the following criteria:(i) A randomized controlled trial (RCT), prospective or retrospective cohort study examining the relationship between Dpp-4i and...
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Miao Wang Muqin Li Ying Xie Source Type: research

Erratum: Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey [Endocrine Journal Vol. 65 (5): 527-536, 2018]
Endocr J. 2021;68(2):251. doi: 10.1507/endocrj.EJ68-2_Errata.NO ABSTRACTPMID:33642456 | DOI:10.1507/endocrj.EJ68-2_Errata (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Source Type: research

Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older
In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804-CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis.PMID:33642417 | DOI:10.1507/endocrj.EJ20-0519 (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Jiseon Lee Hye Won Woo Jihye Kim Min-Ho Shin InSong Koh Bo Youl Choi Mi Kyung Kim Source Type: research

Systematic review and meta-analysis: dipeptidyl peptidase-4 inhibitors and rheumatoid arthritis risk
Endocr J. 2021 Feb 26. doi: 10.1507/endocrj.EJ20-0647. Online ahead of print.ABSTRACTThis review evaluated the risk of rheumatoid arthritis in patients with type 2 diabetes treated with dipeptidyl peptidase-4 inhibitors (Dpp-4i). The MEDLINE (via PubMed), Embase, the Cochrane Library databases and web of science were used to search the effects of Dpp-4i on rheumatoid arthritis in patients with type 2 diabetes from inception to 7 September, 2020. We included studies that met the following criteria:(i) A randomized controlled trial (RCT), prospective or retrospective cohort study examining the relationship between Dpp-4i and...
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Miao Wang Muqin Li Ying Xie Source Type: research

Erratum: Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey [Endocrine Journal Vol. 65 (5): 527-536, 2018]
Endocr J. 2021;68(2):251. doi: 10.1507/endocrj.EJ68-2_Errata.NO ABSTRACTPMID:33642456 | DOI:10.1507/endocrj.EJ68-2_Errata (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Source Type: research

Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older
In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804-CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis.PMID:33642417 | DOI:10.1507/endocrj.EJ20-0519 (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Jiseon Lee Hye Won Woo Jihye Kim Min-Ho Shin InSong Koh Bo Youl Choi Mi Kyung Kim Source Type: research

Systematic review and meta-analysis: dipeptidyl peptidase-4 inhibitors and rheumatoid arthritis risk
Endocr J. 2021 Feb 26. doi: 10.1507/endocrj.EJ20-0647. Online ahead of print.ABSTRACTThis review evaluated the risk of rheumatoid arthritis in patients with type 2 diabetes treated with dipeptidyl peptidase-4 inhibitors (Dpp-4i). The MEDLINE (via PubMed), Embase, the Cochrane Library databases and web of science were used to search the effects of Dpp-4i on rheumatoid arthritis in patients with type 2 diabetes from inception to 7 September, 2020. We included studies that met the following criteria:(i) A randomized controlled trial (RCT), prospective or retrospective cohort study examining the relationship between Dpp-4i and...
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Authors: Miao Wang Muqin Li Ying Xie Source Type: research

Erratum: Twelve-year trends of increasing overweight and obesity in patients with diabetes: the Shiga Diabetes Clinical Survey [Endocrine Journal Vol. 65 (5): 527-536, 2018]
Endocr J. 2021;68(2):251. doi: 10.1507/endocrj.EJ68-2_Errata.NO ABSTRACTPMID:33642456 | DOI:10.1507/endocrj.EJ68-2_Errata (Source: Endocrine Journal)
Source: Endocrine Journal - March 1, 2021 Category: Endocrinology Source Type: research

Silencing long non-coding RNAs nicotinamide nucleotide transhydrogenase antisense RNA 1 inhibited papillary thyroid cancer cell proliferation, migration and invasion and promoted apoptosis via targeting miR-199a-5p
This study explored the growth and apoptosis of PTC cells based on an lncRNA regulatory mechanism. The expression of nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) in PTC cell lines and PTC tissues was analyzed by qRT-PCR. The mutual binding site between NNT-AS1 and miR-199a-5p was predicted by starBase and confirmed by dual-luciferase reporter assay. The correlation between NNT-AS1 and miR-199a-5p was shown by Pearson correlation test. The viability, clone formation, migration, invasion and apoptosis of TPC-1 and IHH-4 cells were examined by CCK-8, colony formation, wound-healing, transwell, and flow c...
Source: Endocrine Journal - February 22, 2021 Category: Endocrinology Authors: DongLiang Wang Ying Zheng Source Type: research

Regulation of solute carrier family 26 member 7 (Slc26a7) by thyroid stimulating hormone in thyrocytes.
Authors: Tanimura Y, Kiriya M, Kawashima A, Mori H, Luo Y, Kondo T, Suzuki K Abstract Iodine transportation is an important step in thyroid hormone biosynthesis. Uptake of iodine into the thyroid follicle is mediated mainly by the basolateral sodium-iodide symporter (NIS or solute carrier family 5 member 5: SLC5A5), and iodine efflux across the apical membrane into the follicular lumen is mediated by pendrin (SLC26A4). In addition to these transporters, SLC26A7, which has recently been identified as a causative gene for congenital hypothyroidism, was found to encode a novel apical iodine transporter in the thyroid....
Source: Endocrine Journal - February 16, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Primary ovarian insufficiency in a female with phosphomannomutase-2 gene (PMM2) mutations for congenital disorder of glycosylation.
Authors: Masunaga Y, Mochizuki M, Kadoya M, Wada Y, Okamoto N, Fukami M, Kato F, Saitsu H, Ogata T Abstract Primary ovarian insufficiency (POI) is a highly heterogeneous condition, and its underlying causes remain to be clarified in a large fraction of patients. Congenital disorders of glycosylation (CDG) are multisystem diseases caused by mutations of a number of genes involved in N-glycosylation or O-glycosylation, and the most frequent form is PMM2-CDG (alias, CDG-Ia) resulting from biallelic mutations in PMM2 encoding phosphomannomutase-2 involved in N-glycosylation. Here, we examined a 46,XX Japanese female wi...
Source: Endocrine Journal - February 16, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

miR-132 mediates cell permeability and migration by targeting occludin in high-glucose -induced ARPE-19 cells.
This study investigated the effects and mechanisms of miR-132 related to the permeability and mobility of human retinal pigment epithelium ARPE-19 cells in high-glucose (HG) condition. ARPE-19 cells were cultured in normal and HG condition and identified by immunofluorescence staining. Cell viability was assessed by the MTT assay, cell permeability was assessed by the FITC-dextran assay and cell mobility was assessed by the wound healing assay. Different miRNA and mRNA expression levels were determined by quantitative real-time polymerase chain reaction (RT-qPCR). The expression of tight junction-related proteins was deter...
Source: Endocrine Journal - February 12, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus.
Authors: Nakayama Y, Yamaguchi S, Shinzato Y, Okamoto S, Millman JF, Yamashiro K, Takemoto N, Uema T, Arakaki K, Higa M, Koizumi H, Shimabukuro M, Masuzaki H Abstract Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (n = 142) and non-proliferative DR (n...
Source: Endocrine Journal - February 9, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Favorable outcomes of papillary thyroid microcarcinoma concurrent with Graves' disease after radioactive iodine therapy.
Authors: Nishihara E, Ito Y, Kudo T, Ito M, Fukata S, Nishikawa M, Akamizu T, Miyauchi A Abstract Graves' disease (GD) may coexist with papillary thyroid microcarcinoma (PTMC). The main purpose of this study was to evaluate whether treatment with radioactive iodine (RAI) may cause acute exacerbation of PTMC concurrent with GD or not. From the medical records of 10,257 GD patients who underwent RAI therapy between 2000-2017, 12 subjects with concurrent PTMC were retrieved. Further, 49 patients with concurrent GD and PTMC who underwent no RAI administration throughout their clinical course were enrolled as controls. ...
Source: Endocrine Journal - February 9, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

ACTH-cortisol dissociation in patients with Kawasaki disease: a retrospective study.
Authors: Aso K, Satoh M Abstract ACTH-cortisol dissociation is recognized in patients with critical illnesses. Cytokines, including tumor necrosis factor-α and interleukin-6 induce hypercortisolemia by enhancing the ACTH-independent synthesis and secretion of cortisol and by reducing cortisol breakdown. Subsequently, hypercortisolemia suppresses ACTH secretion by negative feedback inhibition. ACTH-cortisol dissociation in patients with systemic inflammatory diseases has not been reported. Here, we examined whether ACTH-cortisol dissociation is recognized in patients with Kawasaki disease (KD) associated with ...
Source: Endocrine Journal - February 6, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of fast-acting insulin aspart versus insulin aspart in children and adolescents with type 1 diabetes from Japan.
Authors: Kawamura T, Kikuchi T, Horio H, Rathor N, Ekelund M Abstract The aim of this post-hoc subgroup analysis, which was based on data from the treat-to-target, 26-week, onset 7 trial, was to confirm the efficacy and safety of fast-acting insulin aspart (faster aspart) versus insulin aspart (IAsp), both in combination with basal insulin degludec, in children and adolescents from Japan with type 1 diabetes (T1D). Of the onset 7 trial population (1 to
Source: Endocrine Journal - February 2, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Clinical features and outcomes of metastatic pheochromocytoma treated by cytotoxic chemotherapy.
In conclusion, chemotherapy achieved disease control among more than half of patients, although survival did not differ between responders and nonresponders. Further fundamental research and prospective trials are needed to analyze the efficacy of CVD therapy. PMID: 33518616 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - February 2, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

A survey of surgically resected pituitary incidentalomas and a comparison of the clinical features and surgical outcomes of non-functioning pituitary adenomas discovered incidentally versus symptomatically.
In this study, we first surveyed patients with incidentalomas who underwent surgery. Cases included 62.3% non-functioning adenomas (NFPAs), 14.5% functioning adenomas, and 13.8% Rathke's cleft cysts. Next, we compared the clinical features and surgical outcomes of 145 patients whose preoperative diagnosis was NFPA (incidentalomas [n = 79] vs. symptomatic tumors [n = 66]). The patients with incidentalomas were older (59.9 vs. 55.3 years, p
Source: Endocrine Journal - January 30, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Prognostic significance of 8 weeks' relative dose intensity of lenvatinib in treatment of radioiodine-refractory differentiated thyroid cancer patients.
Authors: Fukuda N, Toda K, Wang X, Ohmoto A, Hayashi N, Urasaki T, Sato Y, Nakano K, Ono M, Tomomatsu J, Mitani H, Takahashi S Abstract Lenvatinib is a standard therapy for radioiodine-refractory differentiated thyroid cancer (RR-DTC). However, because of the high incidence of adverse events resulting from this treatment, it is not easy to maintain the dose intensity of lenvatinib, especially in Japanese patients. Although the prognostic impact of lenvatinib dose interruption has been reported, the target dose intensity of lenvatinib to optimize survival benefits remains unknown. We therefore propose a target dose ...
Source: Endocrine Journal - January 30, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Thyroid complications of SARS and coronavirus disease 2019 (COVID-19).
Authors: Speer G, Somogyi P Abstract We have reviewed the available literature on thyroid diseases and coronavirus disease 2019 (COVID-19), and data from the previous coronavirus pandemic, the severe acute respiratory syndrome (SARS) epidemic. We learned that both SARS and COVID-19 patients had thyroid abnormalities. In the limited number of SARS cases, where it was examined, decreased serum T3, T4 and TSH levels were detected. In a study of survivors of SARS approximately 7% of the patients had hypothyroidism. In the previous evaluation evidence was found that pituitary function was also affected in SARS. Others s...
Source: Endocrine Journal - January 23, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Circular RNA circ_0008274 enhances the malignant progression of papillary thyroid carcinoma via modulating solute carrier family 7 member 11 by sponging miR-154-3p.
Authors: Ma J, Kan Z Abstract CircRNAs have been implicated in the progression of human cancers, including papillary thyroid carcinoma (PTC). Although circ_0008274 has been demonstrated as a potential oncogenic circRNA in PTC, our understanding of its molecular determinants is limited. The levels of circ_0008274, miR-154-3p and solute carrier family 7 member 11 (SLC7A11) mRNA were determined by quantitative real-time polymerase chain reaction (qRT-PCR). SLC7A11 protein level was assessed by western blot. Cell apoptosis, migration, and adhesion capacities were examined by flow cytometry, transwell and cell adhesion ...
Source: Endocrine Journal - January 23, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Application of thermography in the diagnostic investigation of thyroid nodules.
Authors: Damião CP, Montero JRG, Moran MBH, de Oliveira Marçal E Silva Carvalho ME, de Farias CG, Brito IB, Saad MAN, Fontes CAP, Fainstein C, Rodrigues MFO, Palombo A, Conci A, da Cruz Filho RA, Lima GAB Abstract Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method of recording body temperature that measures infrared radiation emitted by ...
Source: Endocrine Journal - January 23, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Risk perception regarding implementation of iodine thyroid blocking during a nuclear disaster of mothers living near a nuclear power station in Japan.
In this study, the perception of risks associated with ITB was investigated in mothers residing near the Sendai Nuclear Power Plant (SNPP) in Kagoshima Prefecture, Japan. Of the 520 mothers surveyed, 467 (89.8%) expressed anxiety regarding the administration of potassium iodine (KI) to their children. Logistic regression analysis revealed that the mothers' anxiety regarding the administration of KI to their children was positively correlated with their wish to consult an expert about KI and their hesitation to let their children eat foods produced in Fukushima, and negatively correlated with having confidence about adminis...
Source: Endocrine Journal - January 23, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Resistin-like molecule beta augments phenotypic modulation of human aortic smooth muscle cell triggered by high glucose.
This study aims to investigate whether Relmβ regulates VSMC phenotypic modulation under high glucose environment. Human aortic vascular smooth muscle cells were cultured and treated with Relmβ in the presence or absence of high glucose. VSMC phenotypic modulation was assessed by expression of related markers. The migration of VSMCs was detected by wound healing assay and transwell assay. The proliferation of VSMCs was measured using CCK-8 assay. In this study, we observed that Relmβ modulated VSMC phenotypic modulation by down-regulating expression of smooth muscle α-actin (α-SMA), smooth muscle ...
Source: Endocrine Journal - January 16, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Short-term fasting reshapes fat tissue.
Authors: Mao T, Wei Q, Zhao F, Zhang C Abstract Intermittent fasting, which can effectively reduce obesity and improve the related metabolic syndrome has become an exciting research area in recent years. Adipose tissue is pivotal in regulating the metabolism and determining the occurrence of obesity. In the current study, we aimed to investigate the effects of acute fasting (AF) on fat tissue. Mice were subjected to AF for 36 h, receiving normal chow (low-fat diet [LFD]) or a high-fat diet (HFD), with free ad libitum access to drinking water, and those fed on free-diet counterparts without fasting serveding as cont...
Source: Endocrine Journal - January 16, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Impairment of CRH in the intestinal mucosal epithelial barrier of pregnant Bama miniature pig induced by restraint stress.
Authors: Xu W, Lu J, Chen Y, Wang Z, Cao J, Dong Y Abstract Female, especially for pregnant female, are vulnerable to psychological stress. The morphology and metabolism of the maternal intestine are both obviously changed during pregnancy, thus making intestinal health status more fragile under psychological stress. The aim of the present study was to investigate the role of CRH and CRHR1 in the pregnant maternal intestine under psychological stress, thus exploring the mechanism of psychological stress in the pregnant maternal intestine. Bama miniature pigs were divided into the control and restraint stress groups...
Source: Endocrine Journal - January 9, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

In patients with type 2 diabetes the presence of Hashimoto's thyroiditis reduces the beneficial effect of dipeptidyl peptidase-4 inhibitor on plasma glucose control.
In this study, we compared the efficacy of a dipeptidyl peptidase-4 inhibitor (DPP4i) to improve glucose control in patients with type 2 diabetes mellitus (T2DM) with or without Hashimoto's thyroiditis (HT). First, we compared the change in glycated hemoglobin (HbA1c) between the hypothyroid condition (before levothyroxine sodium hydrate [LT4] treatment) and euthyroid condition (after LT4 treatment when patients had achieved euthyroidism for at least six months) in patients with T2DM and HT. Next, we compared the change in HbA1c levels before and six months of DPP4i treatment in patients with T2DM with and without HT. In h...
Source: Endocrine Journal - January 9, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Knockdown of plasmacytoma variant translocation 1 (PVT1) inhibits high glucose-induced proliferation and renal fibrosis in HRMCs by regulating miR-23b-3p/early growth response factor 1 (EGR1).
In conclusion, our results suggested that PVT1 knockdown suppressed DN progression though functioning as ceRNA of miR-23b-3p to regulate EGR1 expression in vitro, providing potential value for the treatment of DN. PMID: 33408314 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - January 9, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells.
In this study, we attempted to search the novel target gene(s) of Ang II in the human adrenal H295R cells using a proteomic approach combined with stable isotopic labeling using amino acid in cell culture (SILAC). Interestingly, we found that Ang II stimulation elevated the expression of phosphofructokinase type platelet (PFKP) in both protein and mRNA levels. Moreover, transactivation of PFKP by Ang II was dependent on extracellular-signal-regulated kinase (ERK) 1/2 activation. Finally, we observed that Ang II treatment facilitated glucose uptake in the H295R cells. Taken together, we here identified PFKP as a novel targe...
Source: Endocrine Journal - January 6, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial.
This study was aimed to evaluate the effects of intensive exercise in addition to the administration of sodium-glucose cotransporter 2 inhibitor dapagliflozin (DAPA) on body composition, including fat-free mass, in type 2 diabetes. We randomly assigned 146 patients to 24 weeks of treatment with intensive exercise, including resistance training, plus 5 mg (up to 10 mg) of DAPA daily (IT group) or DAPA alone (CT group). The primary endpoint was the difference in the change in fat-free mass from baseline to 24 weeks between the groups. The skeletal muscle mass index (SMI); metabolic profile, including HbA1c; and regional fat ...
Source: Endocrine Journal - January 6, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Efficacy and safety of fast-acting insulin aspart compared with insulin aspart in combination with insulin degludec in Japanese adults with type 1 diabetes: a subgroup analysis of the randomized onset 8 trial.
This study aimed to confirm the efficacy and safety of mealtime and post-meal fast-acting insulin aspart versus insulin aspart, both with basal insulin degludec, in Japanese patients with type 1 diabetes. This was a subgroup analysis of onset 8, a randomized multicenter, treat-to-target trial of mealtime fast-acting insulin aspart (subgroup n = 73), mealtime insulin aspart (n = 83), or open-label post-meal fast-acting insulin aspart (n = 89), all for 26 weeks. Change from baseline in HbA1c was considered the primary endpoint. After 26 weeks, the estimated treatment difference (ETD, 95% CI) for change from baseline in HbA1c...
Source: Endocrine Journal - January 6, 2021 Category: Endocrinology Tags: Endocr J Source Type: research

Successful management of a patient with active Cushing ‍'‍s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia.
Successful management of a patient with active Cushing‍'‍s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. Endocr J. 2020 Dec 24;: Authors: Yuno A, Kenmotsu Y, Takahashi Y, Nomoto H, Kameda H, Cho KY, Nakamura A, Yamashita Y, Nakamura J, Nakakubo S, Kamada K, Suzuki M, Sugino H, Inoshita N, Konno S, Miyoshi H, Atsumi T, Sawamura Y, Shimatsu A Abstract We provide the details of the successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. The patient was a 27-year-old Japanese female healthcare worker ...
Source: Endocrine Journal - December 30, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study.
Authors: Okamura T, Nakajima H, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Nakanishi N, Hamaguchi M, Asano M, Yamazaki M, Takakuwa H, Fukui M Abstract Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (ND...
Source: Endocrine Journal - December 30, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

The effectiveness of growth hormone replacement on energy expenditure and body composition in patients with adult growth hormone deficiency.
Authors: Momozono A, Hayashi A, Takano K, Shichiri M Abstract Numerous studies have shown that growth hormone (GH) replacement in adult GH deficiency (AGHD) improves the body composition and metabolic rate; however, data about the relationship between body composition and energy expenditure in these patients is scarce. Our study aimed to investigate the changes in resting energy expenditure (REE) and body composition after GH replacement in patients with AGHD. We enrolled 15 patients diagnosed with AGHD and evaluated the effect of GH replacement administered once daily for 12 months on REE, body composition measure...
Source: Endocrine Journal - December 30, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Proposal of diagnostic criteria for IgG4-related thyroid disease.
Authors: Takeshima K, Li Y, Kakudo K, Hirokawa M, Nishihara E, Shimatsu A, Takahashi Y, Akamizu T Abstract Patients with IgG4-related disease (IgG4-RD) are diagnosed in Japan by comprehensive or organ-specific diagnostic criteria. To date, organ-specific criteria have been established for several organs, but not for the thyroid. We attempted to establish diagnostic criteria for IgG4-related thyroid disease (IgG4-RTD) based on IgG4-RD research by The Research Program on Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan. These criteria have been publicly reported to members of both the Jap...
Source: Endocrine Journal - December 16, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Anti-diabetic effects of astaxanthin on an STZ-induced diabetic model in rats.
Authors: Zhuge F, Ni Y, Wan C, Liu F, Fu Z Abstract Type 2 diabetes mellitus (T2DM), which is characterized by insulin resistance and relative insulin insufficiency, has become the most common chronic metabolic disease threatening global health. The preferred therapies for T2DM include lifestyle interventions and the use of anti-diabetic drugs. However, considering their adverse reactions, it is important to find a low-toxicity and effective functional food or drug for diabetes prevention and treatment. Astaxanthin is a potent antioxidant carotenoid found in marine organisms has been reported to prevent diet-induce...
Source: Endocrine Journal - December 4, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Association between serum thyroid hormone balance and thyroid volume in patients treated with levothyroxine monotherapy for hypothyroidism.
Authors: Takahashi S, Ito M, Masaki Y, Hada M, Minakata M, Kohsaka K, Nakamura T, Kasahara T, Kudo T, Nishihara E, Fukata S, Nishikawa M, Akamizu T, Miyauchi A Abstract Many previous studies including ours have reported that athyreotic patients on levothyroxine (LT4) have relatively low serum free triiodothyronine (FT3) levels, whereas patients with large goitrous diseases often have high serum FT3 levels. Here we investigated Hashimoto thyroiditis (HT) patients on LT4 to study the relationship between thyroid volume (TV) and thyroid hormone status in hypothyroid patients on LT4. We retrospectively studied 408 euth...
Source: Endocrine Journal - November 27, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Metreleptin worked in a diabetic woman with a history of hematopoietic stem cell transplantation (HSCT) during infancy: further support for the concept of 'HSCT-associated lipodystrophy'.
In conclusion, metreleptin is useful for the management of HSCT-associated lipodystrophy, supporting the concept that adipose tissue dysfunction is responsible for diverse post-HSCT metabolic aberrations. PMID: 33229817 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 26, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

The impact of a misinterpretation of the term "overtreatment".
The impact of a misinterpretation of the term "overtreatment". Endocr J. 2020 Nov 21;: Authors: Midorikawa S, Ohtsuru A PMID: 33229818 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 26, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Glucose-lowering effects of 7-day treatment with SGLT2 inhibitor confirmed by intermittently scanned continuous glucose monitoring in outpatients with type 1 diabetes. A pilot study.
Authors: Kurozumi A, Okada Y, Tanaka Y Abstract The present study used intermittently scanned continuous glucose monitoring (isCGM) in 10 patients with type 1 diabetes mellitus (T1DM) to evaluate the efficacy and safety of 7-day outpatient treatment with the combination of intensive insulin therapy and sodium-glucose transporter 2 inhibitor (SGLT2-I). All participants wore isCGM and were treated with either 50 mg/day ipragliflozin or 5 mg/day dapagliflozin. The primary outcome, percent time with glucose at 70-180 mg/dL (TIR: time in range), improved significantly following the addition of SGLT2-I (p = 0.005). TIR i...
Source: Endocrine Journal - November 21, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

A case of postpartum thyroiditis following SARS-CoV-2 infection.
In conclusion, although a clear causal relationship could not be found, we documented the world's first case of PPT developed following COVID-19. PMID: 33177251 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 14, 2020 Category: Endocrinology Tags: Endocr J Source Type: research