Age at menarche in Japanese patients with type 1 diabetes mellitus: a look at changes since 1960s
Endocr J. 2022 Jan 12. doi: 10.1507/endocrj.EJ21-0533. Online ahead of print.ABSTRACTMenarche is delayed in patients with type 1 diabetic mellitus (T1DM) compared to non-diabetics. The purpose of this survey study was to define the age of onset of menarche in Japanese patients with T1DM, as well the secular trends in menarcheal age across the period of 1976-2020 and determine the effects of T1DM and disease management on that age. The study subjects (n = 155) were recruited from among Japanese T1DM patients who visited the outpatient clinic of the Department of Pediatrics, Osaka City University Hospital. The study subjects...
Source: Endocrine Journal - January 13, 2022 Category: Endocrinology Authors: Naoko Nishikawa-Nakamura Tomoyuki Kawamura Tatsuya Nakamichi Yoshihiko Yuyama Yuko Hotta Kayako Hashimura Tomomi Hashimoto Masakazu Hirose Takashi Higashide Takashi Hamazaki Source Type: research

Investigation of pituitary functions after acute coronavirus disease 2019
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0531. Online ahead of print.ABSTRACTAlthough coronavirus disease 2019 (COVID-19) mainly involves the lungs, it also affects many systems. The hypothalamic/pituitary axis is vulnerable to hypoxia, hypercoagulation, endothelial dysfunction and autoimmune changes induced by COVID-19 infection. Given that there is no extensive investigation on this issue, we investigated the pituitary functions three to seven months after acute COVID-19 infection. Forty-three patients after diagnosis of COVID-19 infection and 11 healthy volunteers were included in the study. In addition to the ba...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Emre Urhan Zuleyha Karaca Gamze Kalin Unuvar Kursat Gundogan Kursad Unluhizarci Source Type: research

Double water-clear cell parathyroid adenoma: a case report and literature review
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0590. Online ahead of print.ABSTRACTWater-clear cell parathyroid adenoma is an uncommon cause of primary hyperparathyroidism. Herein, we report an interesting case of a 56-year-old man who presented with weight loss, bone pain, fatigue, and a palpable right neck mass. Laboratory tests indicated hypercalcemia, elevated parathyroid hormone (PTH) levels, and normal thyroid function. Further examinations detected osteoporosis and kidney stones. The ultrasound of neck revealed bilateral extrathyroidal tumors, which were sestamibi-avid. The patient underwent resection of the large ...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Chia-An Yang Jiun-Lu Lin Shuen-Han Dai Shih-Ping Cheng Source Type: research

Investigation of pituitary functions after acute coronavirus disease 2019
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0531. Online ahead of print.ABSTRACTAlthough coronavirus disease 2019 (COVID-19) mainly involves the lungs, it also affects many systems. The hypothalamic/pituitary axis is vulnerable to hypoxia, hypercoagulation, endothelial dysfunction and autoimmune changes induced by COVID-19 infection. Given that there is no extensive investigation on this issue, we investigated the pituitary functions three to seven months after acute COVID-19 infection. Forty-three patients after diagnosis of COVID-19 infection and 11 healthy volunteers were included in the study. In addition to the ba...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Emre Urhan Zuleyha Karaca Gamze Kalin Unuvar Kursat Gundogan Kursad Unluhizarci Source Type: research

Double water-clear cell parathyroid adenoma: a case report and literature review
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0590. Online ahead of print.ABSTRACTWater-clear cell parathyroid adenoma is an uncommon cause of primary hyperparathyroidism. Herein, we report an interesting case of a 56-year-old man who presented with weight loss, bone pain, fatigue, and a palpable right neck mass. Laboratory tests indicated hypercalcemia, elevated parathyroid hormone (PTH) levels, and normal thyroid function. Further examinations detected osteoporosis and kidney stones. The ultrasound of neck revealed bilateral extrathyroidal tumors, which were sestamibi-avid. The patient underwent resection of the large ...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Chia-An Yang Jiun-Lu Lin Shuen-Han Dai Shih-Ping Cheng Source Type: research

Investigation of pituitary functions after acute coronavirus disease 2019
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0531. Online ahead of print.ABSTRACTAlthough coronavirus disease 2019 (COVID-19) mainly involves the lungs, it also affects many systems. The hypothalamic/pituitary axis is vulnerable to hypoxia, hypercoagulation, endothelial dysfunction and autoimmune changes induced by COVID-19 infection. Given that there is no extensive investigation on this issue, we investigated the pituitary functions three to seven months after acute COVID-19 infection. Forty-three patients after diagnosis of COVID-19 infection and 11 healthy volunteers were included in the study. In addition to the ba...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Emre Urhan Zuleyha Karaca Gamze Kalin Unuvar Kursat Gundogan Kursad Unluhizarci Source Type: research

Double water-clear cell parathyroid adenoma: a case report and literature review
Endocr J. 2022 Jan 6. doi: 10.1507/endocrj.EJ21-0590. Online ahead of print.ABSTRACTWater-clear cell parathyroid adenoma is an uncommon cause of primary hyperparathyroidism. Herein, we report an interesting case of a 56-year-old man who presented with weight loss, bone pain, fatigue, and a palpable right neck mass. Laboratory tests indicated hypercalcemia, elevated parathyroid hormone (PTH) levels, and normal thyroid function. Further examinations detected osteoporosis and kidney stones. The ultrasound of neck revealed bilateral extrathyroidal tumors, which were sestamibi-avid. The patient underwent resection of the large ...
Source: Endocrine Journal - January 6, 2022 Category: Endocrinology Authors: Chia-An Yang Jiun-Lu Lin Shuen-Han Dai Shih-Ping Cheng Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Whole body vibration activates AMPK/CPT1 signaling pathway of skeletal muscle in young and aging mice based on metabolomics study
Endocr J. 2021 Dec 24. doi: 10.1507/endocrj.EJ21-0343. Online ahead of print.ABSTRACTWhole-body vibration (WBV) can improve skeletal muscle function in aging mice, but whether the effect on young and aging skeletal muscle is consistent has not been studied. We selected C57BL/6J mouse models, which were divided into young control group (YC), young vibration group (YV), aging control group (AC) and aging vibration group (AV). After 12 weeks of WBV, we found that compared with the YC group, the pathways of linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, nicotinate and nicotinami...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Dingwen Jiang Chang Liu Ye Chen Xuejiao Xing Danmeng Zheng Source Type: research

Analysis of thyroid function in Japanese patients with coronavirus disease 2019
In this study, we sought to clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and whether these hormones could be better predictors of prognosis in patients with coronavirus disease 2019 (COVID-19). Accordingly, we retrospectively examined 147 cases wherein thyroid hormones were measured at the time of admission among 848 Japanese patients with COVID-19 admitted to the Hyogo Prefectural Kakogawa Medical Center. All patients underwent thyroid function testing upon hospital admission. More than half (59.1%) of the patients were euthyroid. Twenty-four percent of patients had serum thyroid-stimulating h...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Sachiko Nakamura Nozomi Kido Miki Watanabe Yuka Ohmachi Yuko Inayama Yuya Kashitani Keiko Ishii Ikuhiro Ishida Naho Goda Yasunori Fujita Keiji Iida Source Type: research

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity
In conclusion, it is difficult to evaluate childhood obesity only with height and weight.PMID:34955474 | DOI:10.1507/endocrj.EJ21-0434 (Source: Endocrine Journal)
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Reiko Masubuchi Masahiro Noda Satomi Yoshida Koji Kawakami Source Type: research

Observational management of papillary microcarcinoma appearing in the remnant thyroid after hemithyroidectomy
Endocr J. 2021 Dec 25. doi: 10.1507/endocrj.EJ21-0557. Online ahead of print.ABSTRACTActive surveillance for papillary thyroid microcarcinomas (PTMCs) initiated in Japan is becoming adopted worldwide as a management option. However, it remains unclear how to manage newly appearing PTMCs in the remnant thyroid after hemithyroidectomy. We investigated the outcomes of similar observational management (OM) for PTMCs appearing in the remnant thyroid after hemithyroidectomy for papillary thyroid carcinoma (PTC) and benign thyroid nodules. Eighty-three patients were newly diagnosed with PTMC in the remnant thyroid between January...
Source: Endocrine Journal - December 27, 2021 Category: Endocrinology Authors: Takuya Noda Akira Miyauchi Yasuhiro Ito Takumi Kudo Tsutomu Sano Takahiro Sasaki Takahito Ando Masatoshi Yamamoto Makoto Fujishima Hiroo Masuoka Takuya Higashiyama Minoru Kihara Naoyoshi Onoda Akihiro Miya Source Type: research

Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model
Endocr J. 2021 Dec 22. doi: 10.1507/endocrj.EJ21-0447. Online ahead of print.ABSTRACTDiabetic kidney disease is an important and common cause of end-stage renal disease. Measurement of urinary albumin excretion (UAE) requires the diagnosis of the stage of diabetic nephropathy and the prognosis of renal function. We aimed to analyze the impact of lifestyle modification on UAE in patients with stage 2 and 3 type 2 diabetic nephropathy who received comprehensive medical care, using a generalized additive model (GAM), an explanatory machine learning model. In this retrospective observational study, we used changes in HbA1c, sy...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Yuka Kotake Shigehiro Karashima Masaki Kawakami Satoshi Hara Daisuke Aono Seigo Konishi Mitsuhiro Kometani Hiroyuki Mori Yoshiyu Takeda Takashi Yoneda Hidetaka Nambo Kenji Furukawa Source Type: research

Clinical feasibility of remote intermittently scanned continuous glucose monitoring in coronavirus disease 2019 patients with and without diabetes during dexamethasone therapy
In conclusion, although isCGM may not be as accurate as traditional blood glucose monitoring, it has good reliability in COVID-19 patients with and without diabetes during dexamethasone therapy.PMID:34937812 | DOI:10.1507/endocrj.EJ21-0540 (Source: Endocrine Journal)
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Naoya Shimizu Akinori Hayashi Shiori Ito Agena Suzuki Rei Fujishima Kenta Matoba Tatsuhiko Wada Koji Takano Masato Katagiri Masayoshi Shichiri Source Type: research

Expression and mechanism of microRNA 195 in diabetic retinopathy
Endocr J. 2021 Dec 23. doi: 10.1507/endocrj.EJ21-0231. Online ahead of print.ABSTRACTWe aimed to explore the role of microRNA 195 (miR-195) in diabetic retinopathy (DR). From January 2019 to July 2020, 50 patients with DR undergoing vitrectomy and 40 patients with idiopathic macular holes undergoing vitrectomy were selected as the observation group (OG) and control group (CG), respectively. The mRNA and protein expression levels of miR-195, SIRT1, BAX, and BCL-2 were detected in the retinal tissues obtained from the two groups during surgery. In addition, human retinal endothelial cells and human dermal microvascular endot...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Li Shan Haiyong Zhang Ying Han Ruijuan Kuang Source Type: research

Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model
Endocr J. 2021 Dec 22. doi: 10.1507/endocrj.EJ21-0447. Online ahead of print.ABSTRACTDiabetic kidney disease is an important and common cause of end-stage renal disease. Measurement of urinary albumin excretion (UAE) requires the diagnosis of the stage of diabetic nephropathy and the prognosis of renal function. We aimed to analyze the impact of lifestyle modification on UAE in patients with stage 2 and 3 type 2 diabetic nephropathy who received comprehensive medical care, using a generalized additive model (GAM), an explanatory machine learning model. In this retrospective observational study, we used changes in HbA1c, sy...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Yuka Kotake Shigehiro Karashima Masaki Kawakami Satoshi Hara Daisuke Aono Seigo Konishi Mitsuhiro Kometani Hiroyuki Mori Yoshiyu Takeda Takashi Yoneda Hidetaka Nambo Kenji Furukawa Source Type: research

Clinical feasibility of remote intermittently scanned continuous glucose monitoring in coronavirus disease 2019 patients with and without diabetes during dexamethasone therapy
In conclusion, although isCGM may not be as accurate as traditional blood glucose monitoring, it has good reliability in COVID-19 patients with and without diabetes during dexamethasone therapy.PMID:34937812 | DOI:10.1507/endocrj.EJ21-0540 (Source: Endocrine Journal)
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Naoya Shimizu Akinori Hayashi Shiori Ito Agena Suzuki Rei Fujishima Kenta Matoba Tatsuhiko Wada Koji Takano Masato Katagiri Masayoshi Shichiri Source Type: research

Expression and mechanism of microRNA 195 in diabetic retinopathy
Endocr J. 2021 Dec 23. doi: 10.1507/endocrj.EJ21-0231. Online ahead of print.ABSTRACTWe aimed to explore the role of microRNA 195 (miR-195) in diabetic retinopathy (DR). From January 2019 to July 2020, 50 patients with DR undergoing vitrectomy and 40 patients with idiopathic macular holes undergoing vitrectomy were selected as the observation group (OG) and control group (CG), respectively. The mRNA and protein expression levels of miR-195, SIRT1, BAX, and BCL-2 were detected in the retinal tissues obtained from the two groups during surgery. In addition, human retinal endothelial cells and human dermal microvascular endot...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Li Shan Haiyong Zhang Ying Han Ruijuan Kuang Source Type: research

Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model
Endocr J. 2021 Dec 22. doi: 10.1507/endocrj.EJ21-0447. Online ahead of print.ABSTRACTDiabetic kidney disease is an important and common cause of end-stage renal disease. Measurement of urinary albumin excretion (UAE) requires the diagnosis of the stage of diabetic nephropathy and the prognosis of renal function. We aimed to analyze the impact of lifestyle modification on UAE in patients with stage 2 and 3 type 2 diabetic nephropathy who received comprehensive medical care, using a generalized additive model (GAM), an explanatory machine learning model. In this retrospective observational study, we used changes in HbA1c, sy...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Yuka Kotake Shigehiro Karashima Masaki Kawakami Satoshi Hara Daisuke Aono Seigo Konishi Mitsuhiro Kometani Hiroyuki Mori Yoshiyu Takeda Takashi Yoneda Hidetaka Nambo Kenji Furukawa Source Type: research

Clinical feasibility of remote intermittently scanned continuous glucose monitoring in coronavirus disease 2019 patients with and without diabetes during dexamethasone therapy
In conclusion, although isCGM may not be as accurate as traditional blood glucose monitoring, it has good reliability in COVID-19 patients with and without diabetes during dexamethasone therapy.PMID:34937812 | DOI:10.1507/endocrj.EJ21-0540 (Source: Endocrine Journal)
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Naoya Shimizu Akinori Hayashi Shiori Ito Agena Suzuki Rei Fujishima Kenta Matoba Tatsuhiko Wada Koji Takano Masato Katagiri Masayoshi Shichiri Source Type: research

Expression and mechanism of microRNA 195 in diabetic retinopathy
Endocr J. 2021 Dec 23. doi: 10.1507/endocrj.EJ21-0231. Online ahead of print.ABSTRACTWe aimed to explore the role of microRNA 195 (miR-195) in diabetic retinopathy (DR). From January 2019 to July 2020, 50 patients with DR undergoing vitrectomy and 40 patients with idiopathic macular holes undergoing vitrectomy were selected as the observation group (OG) and control group (CG), respectively. The mRNA and protein expression levels of miR-195, SIRT1, BAX, and BCL-2 were detected in the retinal tissues obtained from the two groups during surgery. In addition, human retinal endothelial cells and human dermal microvascular endot...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Li Shan Haiyong Zhang Ying Han Ruijuan Kuang Source Type: research

Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model
Endocr J. 2021 Dec 22. doi: 10.1507/endocrj.EJ21-0447. Online ahead of print.ABSTRACTDiabetic kidney disease is an important and common cause of end-stage renal disease. Measurement of urinary albumin excretion (UAE) requires the diagnosis of the stage of diabetic nephropathy and the prognosis of renal function. We aimed to analyze the impact of lifestyle modification on UAE in patients with stage 2 and 3 type 2 diabetic nephropathy who received comprehensive medical care, using a generalized additive model (GAM), an explanatory machine learning model. In this retrospective observational study, we used changes in HbA1c, sy...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Yuka Kotake Shigehiro Karashima Masaki Kawakami Satoshi Hara Daisuke Aono Seigo Konishi Mitsuhiro Kometani Hiroyuki Mori Yoshiyu Takeda Takashi Yoneda Hidetaka Nambo Kenji Furukawa Source Type: research

Clinical feasibility of remote intermittently scanned continuous glucose monitoring in coronavirus disease 2019 patients with and without diabetes during dexamethasone therapy
In conclusion, although isCGM may not be as accurate as traditional blood glucose monitoring, it has good reliability in COVID-19 patients with and without diabetes during dexamethasone therapy.PMID:34937812 | DOI:10.1507/endocrj.EJ21-0540 (Source: Endocrine Journal)
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Naoya Shimizu Akinori Hayashi Shiori Ito Agena Suzuki Rei Fujishima Kenta Matoba Tatsuhiko Wada Koji Takano Masato Katagiri Masayoshi Shichiri Source Type: research

Expression and mechanism of microRNA 195 in diabetic retinopathy
Endocr J. 2021 Dec 23. doi: 10.1507/endocrj.EJ21-0231. Online ahead of print.ABSTRACTWe aimed to explore the role of microRNA 195 (miR-195) in diabetic retinopathy (DR). From January 2019 to July 2020, 50 patients with DR undergoing vitrectomy and 40 patients with idiopathic macular holes undergoing vitrectomy were selected as the observation group (OG) and control group (CG), respectively. The mRNA and protein expression levels of miR-195, SIRT1, BAX, and BCL-2 were detected in the retinal tissues obtained from the two groups during surgery. In addition, human retinal endothelial cells and human dermal microvascular endot...
Source: Endocrine Journal - December 23, 2021 Category: Endocrinology Authors: Li Shan Haiyong Zhang Ying Han Ruijuan Kuang Source Type: research

Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents
Endocr J. 2021 Dec 17. doi: 10.1507/endocrj.EJ21-0560. Online ahead of print.ABSTRACTThe triglyceride-glucose (TyG) index is associated with predicting type 2 diabetes mellitus (T2DM), but its relationship with homeostatic model assessment of insulin resistance (HOMA-IR) in T2DM is not established. We aimed to investigate the role of TyG index for detection of T2DM in children and adolescents and compare it with HOMA-IR. A cross sectional study was performed in 176 overweight or obese children and adolescents with mean age of 11.34 ± 3.24 years. TyG index was calculated as ln (fasting triglyceride (TG) [mg/dL] &time...
Source: Endocrine Journal - December 20, 2021 Category: Endocrinology Authors: Jong Seo Yoon Hye Jin Lee Hwal Rim Jeong Young Suk Shim Min Jae Kang Il Tae Hwang Source Type: research