Diabetes mellitus exacerbates post ‐myocardial infarction heart failure by reducing sarcolipin promoter methylation

ConclusionsDiabetes increases the vulnerability of STEMI patients to post ‐MI HF by down‐regulating SLN promoter methylation, which further regulates SERCA2a activity via increasing cardiac SLN expression.

Source: ESC Heart Failure - June 10, 2020 Category: Cardiology Authors: Zhongwei Liu, Yong Zhang, Chuan Qiu, Haitao Zhu, Shuo Pan, Hao Jia, Hongyan Kang, Gongchang Guan, Rutai Hui, Ling Zhu, Junkui Wang Tags: Original Research Article Source Type: research