Long Non-Coding RNA (lncRNA) SNHG5 Participates in Vertical Sleeve Gastrectomy for Type II Diabetes Mellitus by Regulating TGR5.

CONCLUSIONS By downregulating expression of the SNHG5 gene and then altering expression of the TGR5 gene, the damage to colorectal cells induced by high glucose was alleviated. This may be one of the mechanisms underlying the effect of sleeve gastric surgery in treatment of diabetes mellitus. PMID: 32242546 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Abstract Background: Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. Material and Methods. A total of 22 male Sprague-Dawley rats with type 2 diabetes were randomly assigned into 3 different groups: (1) sleeve gastroplasty with gastric remnant-jejunal anastomosis (SGP, n = 8); (2) sleeve gastrectomy (SG, n = 8); and (3) SHAM (n = 6). Body weight, food intake, fasting blood glucose (FBG), hormonal analysis, and oral glucose tolerance test (OGTT) were...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Laparoscopic sleeve gastrectomy (SG) achieves type 2 diabetes mellitus (T2D) remission to various extents, and reasons for such variations are unknown.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
In conclusion, SG is an effective procedure for weight loss with a low risk for the patient to develop malnutrition. In terms of post-operative care, regular check-ups are vital to ensure a positive outcome as well as for the early detection of possible issues. Reflux and weight regain are common issues with SG in a long-term follow-up; thus, patients should be selected carefully for this procedure. PMID: 32359172 [PubMed - as supplied by publisher]
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
Obesity is a world-wide epidemic and it is a risk factor for type 2 diabetes mellitus (T2D). Few randomized controlled studies have compared the two most common surgical procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in the treatment of obese subjects with T2D.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
The abstract, “Effect of 1-Anastamosis-Gastric Bypass and Sleeve Gastrectomy on Type 2 Diabetes Mellitus According to Its Severity Using a Standardized Surgery Score,” which appeared in the October 2019 Supplement issue of the Journal of the American College of Surgeons, Volume 229, Number 4, (Supplement 2), page e68, was published without the full author list. The correct author list for this abstract is: Bassem M Abou-Hussein, MBBS, FACS, Ali Khammas, MD, Hana Fardan, MD, Ahmad Yaakub, MD, Benan Al Shehhi, MD, Omar Al Marzouqi, MD, FRCS.
Source: Journal of the American College of Surgeons - Category: Surgery Tags: Correction Source Type: research
As recently summarized1, there are only four randomized clinical trials (RCTs) in patients with type 2 diabetes mellitus (T2DM) comparing Roux-en-Y gastric bypass (RYGB) with sleeve gastrectomy (SG) and providing level I evidence up to 5 years after randomization.2-5 None of the individual studies were primarily designed and adequately powered to compare the effects of RYGB with SG on T2DM. However, combined analysis of these RCTs (i.e. meta-analysis) in order to increase the sample size and statistical power (RYGB, n=176 versus SG, n=175) would indicate that either there is no significant long-term difference between RYGB...
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Objective: We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG).Design: Retrospective cohort study.Setting: Single tertiary care academic referral center.Participants: One hundred fifty adolescent (≤ 21-years) and adult (>21-years) subjects with severe obesity between 15 and 70 years of age who underwent RYGB or SG.Outcomes: Metabolic parameters, weight and height measures were obtained pre-and post-surgery (at 3 and 6 months, and then annually for 4 years).Results: Median pre-surgical body mass index (BM...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionOur preliminary scoring system attains a good level of accuracy for predicting T2DM remission.
Source: Surgery Today - Category: Surgery Source Type: research
WEDNESDAY, March 4, 2020 -- Most patients with type 2 diabetes mellitus (T2DM) undergoing bariatric surgery experience T2DM remission during five years of follow-up, but outcomes are superior with Roux-en-Y gastric bypass (RYGB) compared with sleeve...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionsMild-to-moderate PPHG is a frequent complication after bariatric surgery and results in smaller weight loss after 2  years. Age, baseline BMI, and an earlier glucose peak during OGTT predict PPHG after bariatric surgery.
Source: Obesity Surgery - Category: Surgery Source Type: research
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