Therapy for relapsed multiple myeloma.
Authors: Aljama MA, Sidiqi MH, Dingli D Abstract Despite significant progress in our understanding and the development of novel therapies, most patients with multiple myeloma will experience relapse of their disease. Therapy of relapsed myeloma has improved due to the availability of novel agents that are highly active against the disease. However, the selection of therapy can be challenging due to the emergence of toxicities, comorbidities and frailty. In the following we discuss our approach to the treatment of the patient with relapsed myeloma. PMID: 30303355 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - October 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Pulmonary endoscopy emergencies.
We describe the main pathological conditions where urgent bronchoscopy is crucial because they act through mechanisms such as airway obstruction or alteration of the anatomic integrity of the tracheobronchial tree. We point out the problems resulting from inhalation of foreign bodies, one of the most dramatic respiratory emergencies typical of childhood which needs not only the appropriate endoscopic equipment suitable for the age, but also great experience in the management of the possible related complications. Massive haemoptysis is then discussed in order to help choosing the right endoscope and to clarify the steps re...
Source: Panminerva Medica - October 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Childhood obesity.
Authors: Kumar S, Kaufman T Abstract Childhood obesity has assumed epidemic proportions and it is currently one of the most prevalent public health problems. The pathophysiology of excess weight gain is complex with interactions between genetic factors, environment and biological factors. In this review, we highlight the epidemiology of childhood obesity and discuss clinical evaluation of a child with obesity. A staged approach to treatment is detailed. We discuss the role of lifestyle modifications, pharmacotherapy and bariatric surgery as treatment strategies. PMID: 30303357 [PubMed - as supplied by publisher...
Source: Panminerva Medica - October 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Irritable bowel syndrome: the clinical approach.
Authors: Adriani A, Ribaldone DG, Astegiano M, Durazzo M, Saracco GM, Pellicano R Abstract Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder which presents with abdominal pain associated with alteration of bowel habits. IBS is a common condition affecting 9-23% of the general population, being the 80% female, with considerable impact on quality of life and health care costs. The exact pathogenesis of IBS remains elusive, but is clearly multifactorial and includes environmental and host factors. Management of patients with IBS is challenging since diagnosis and treatme...
Source: Panminerva Medica - September 28, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Peroxisome proliferator-activated receptor gamma: promising target in glioblastoma.
Authors: Gupta G, Singhvi G, Chellappan DK, Sharma S, Mishra A, Dahiya R, de Jesus Andreoli Pinto T, Dua K Abstract Glioblastoma, also known as glioblastoma multiforme, is the most common and worldwide-spread cancer that begins within the brain. Glioblastomas represent 15% of brain tumors. The most common length of survival following diagnosis is 12 to 14 months with less than 3% to 5% of people surviving longer than five years. Without treatment, survival is typically 3 months. Among all receptors, special attention has been focused on the role of peroxisome proliferator-activated receptors (PPARs) in glioblastoma...
Source: Panminerva Medica - September 5, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Nanotechnology in drug delivery gaining new perspectives in respiratory diseases.
Authors: Dua K, Madan JR, Chellappan DK, Gupta G PMID: 30176702 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - September 5, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Why is there an emerging need to look for a suitable drug delivery platform in targeting and regulating microbiota?
Authors: Dua K, Gupta G, Awasthi R, Chellappan DK PMID: 30176703 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - September 5, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

The correlation of pharyngeal morphology and obstructive sleep apnea in patients with recent stroke.
Authors: Zhang L, Wu Q, Zhang Q, Lu G, Yuan Y, Wang T PMID: 30021417 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - July 20, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Novel approaches for diagnosis and management of low prognosis patients in ART: the POSEIDON concept.
Authors: Conforti A, Esteves SC, Strina I, Picarelli S, Iorio G, Rania E, Zullo F, De Placido G, Alviggi C Abstract The management of patients with a poor ovarian response (POR) to ovarian stimulation represents a challenging issue in reproductive medicine. Apart from economic burdens, the patient with POR has poor prognosis in assisted reproductive technology (ART), which represents a common cause of drop-out from treatment. To introduce a more nuanced picture of POR, the POSEIDON group developed novel criteria to identify and classify patients with low prognosis who undergo ART. The primary goal of POSEIDON crite...
Source: Panminerva Medica - July 20, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Paternal age and assisted reproductive technologies: problem solver or trouble maker?
Authors: Bertoncelli Tanaka M, Agarwal A, Esteves SC Abstract In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) a...
Source: Panminerva Medica - July 20, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Testosterone and male rejuvenation.
Authors: Helo S, Thomas P, Tadros NN Abstract Testosterone has long been touted as the panacea for men wishing to restore their vitality, sexuality, and masculinity to that of their youth. While the benefits of testosterone are not mythical, they are definite. In this article we will review the various benefits of testosterone as it pertains to men's health and male infertility. PMID: 29991207 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - July 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Hepatitis C virus, alcohol use disorders and hepatocellular carcinoma.
Authors: Testino G, Leone S, Fagoonee S PMID: 29991208 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - July 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.
Authors: Di Pierro F, Risso P, Settembre R Abstract BACKGROUND: Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. Several trials have found hypericum to be more effective than placebo or some antidepressant drugs, but the exact mechanism and most relevant compounds are still unclear. A possible hypothesis is that the antidepressant activity might be due to its multiplicity of bioactive compounds. Aim is to test if greater chemical complexity could result in a greater hypericum antidepressant action. METHODS: A retrospective, 12-month, open-label, observational, controlled...
Source: Panminerva Medica - July 13, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Effects of Rosuvastatin in combination with Nimodipine in patients with mild cognitive impairment caused by CSVD.
Authors: Zhang J, Liu N, Yang C Abstract BACKGROUND: To investigate the clinical efficiency and safeness of the combination of rosuvastatin and nimodipine in treating mild cognitive impairment of CSVD patients. METHODS: A total of 120 patients with mild cognitive impairment caused by CSVD were divided randomly into two groups: an observation group and a control group, each of which had 60 patients. In the observation group, patients were given rosuvastatin in combination with nimodipine, and other patients were given nimodipine in the control group. For the two groups, the course of treatment was six months. Be...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Impact of body mass index on female fertility and ART outcomes.
Authors: Imterat M, Agarwal A, Esteves SC, Meyer J, Harlev A Abstract As the global mean body mass index (BMI) is on the rise, the importance of understanding exactly how female fertility is impacted by once outlier BMI values, becomes ever more important. Studies have implicated abnormal BMI impacts the female reproductive system by contributing to anovulation, irregular menses, adverse oocyte quality, endometrial alterations, and hormonal imbalances that ultimately result in female infertility, which could complicate natural conception efforts and request considering assisted reproductive technology (ART) in such...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Prevention of pressure ulcers with a motorized air support in at-risk patients hospitalized in rehabilitation departments APAM + an observational prevalence study with historical control and incidence study.
Authors: Barrois B, Gaubert-Dahan ML, Allaert FA, Urzica I, Bordet B, Michel JM, Blanchon MA, Chol C Abstract BACKGROUND: The main study was a cross-sectional multicenter study of the prevalence of pressure ulcers in rehabilitation services (RS) where Axtair Automorpho® Plus mattresses were made available ad libitum. The primary objective was to enable comparison with prevalence as observed in the national PER SE study (historical control) in similar departments using a variety of prevention aids. METHODS: This cross-sectional prevalence study was combined with a prospective study of the incidence of pressu...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Freeze-all strategy in IVF/ICSI cycles: an update on clinical utility.
Authors: Roque M, Nuto Nóbrega B, Valle M, Sampaio M, Geber S, Haahr T, Humaidan P, Esteves SC Abstract Over the years concerns have arisen about possible adverse effects associated with controlled ovarian stimulation (COS) as regards not only the endometrium, but also on obstetrical and perinatal outcomes in pregnancies after fresh embryo transfer (ET) during in vitro fertilization (IVF) treatment. The improvements in cryopreservation techniques associated with the possible impairment in endometrial receptivity due to the supra-physiologic hormonal levels observed during conventional COS have increased the ...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.
Authors: Bedoschi GM, Navarro PA, Oktay KH Abstract Cancer is a worldwide public health problem and is the second leading cause of death in the United States. Early detection of cancer and advancement of treatment modalities contributed to declining mortality rates. Consequently, survival rates increased, leading to a greater interest in maintaining the quality of life after cancer treatment. Adjuvant chemotherapy results in an improvement in both disease-free and overall survival. However, chemotherapy treatment is associated with acute and long- term complications for cancer survivors. A special concern of women ...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

The state of the art of preimplantation genetic testing in ART.
Authors: Romanelli V, Poli M, Capalbo A Abstract Preimplantation genetic testing is a methodology aimed at the assessment of the genetic composition of an embryo. This diagnostic approach has been used in assisted reproduction for almost thirty years. During these years, the technologies used for embryo's genetic analysis have been continuously improved allowing the development of more precise, comprehensive and robust strategies that are clinically employed nowadays. In this review, the main diagnostic approaches used for embryo genetic and chromosomal assessment are described and discussed both from an embryologi...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Estimation of age-dependent decrease in blastocyst euploidy by next generation sequencing: development of a novel prediction model.
Authors: Esteves SC, Carvalho JF, Martinhago CD, Melo AA, Bento FC, Humaidan P, Alviggi C, POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) Group Abstract BACKGROUND: We developed a model to estimate the female age-dependent decrease in blastocyst euploidy and the impact of blastocyst cohort size on the likelihood of having at least one euploid blastocyst for transfer. METHODS: Retrospective analysis of 1,296 trophectoderm biopsies by next-generation sequencing analysis from 436 infertile couples undergoing intracytoplasmic sperm injection and preimplantation genetic testing for ...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Methods of surgical sperm extraction and implications for ART success.
Authors: Miyaoka R, Orosz JE, Achermann AP, Esteves SC Abstract Intracytoplasmic sperm injection (ICSI) was developed to overcome the most severe forms of male factor infertility, including azoospermia. Retrieval of the male gamete from the epididymis or testis offers the possibility to perform ICSI and to provide biological parenthood for the affected men. Although reconstruction of the seminal tract is possible in many men with obstructive azoospermia (OA), this approach may not be feasible or desired by the couple 1. Unlike OA, non-obstructive azoospermia (NOA) is usually an untreatable condition associated with...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Mitochondria and reproduction: possibilities for testing and treatment.
Authors: Kristensen SG, Humaidan P, Coetzee K Abstract Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital cellular processes and affect all aspects of mammalian reproduction, being essential for oocyte maturation, fertilization and embryonic development. Mitochondrial dysfunction is consequently implicated in disease as well as age-related infertility. Since mitochondria are inherited exclusively from the mother, the female gamete is central to reproductive outcome and therapeutic interventions, such as mitochondrial replacement therapies (MRT), and development of new dia...
Source: Panminerva Medica - July 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Pharmacogenetic algorithm for individualized controlled ovarian stimulation (iCOS) in assisted reproductive technology cycles.
Authors: Roque M, Bianco B, Christofolini DM, Cordts EB, Vilarino FL, Carvalho W, Valle M, Sampaio M, Geber S, Esteves SC, Barbosa CP Abstract Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to...
Source: Panminerva Medica - June 20, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Clinical significance of serum NT-proBNP in patients with acute cerebral stroke.
Authors: Yang Q, Li C, Wang L, Wei B Abstract BACKGROUND: To investigate the relationships of the changes of serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) level with the severity of the disease [infarct size, amount of bleeding, national institutes of health stroke scale (NIHSS)score and Glasgow coma scale(GCS) score] and prognosis in acute cerebral stroke patients. METHODS: Acute cerebral stroke patients admitted to our hospital from August 2015 to August 2017 were enrolled in this study. The NT-proBNP level, infarct size, amount of bleeding, NIHSS score, GCS score and Modified Rankin Scale (MRS)...
Source: Panminerva Medica - June 9, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Gender differences in chronic obstructive pulmonary diseases: a narrative review.
Authors: Nicolini A, Barbagelata E, Tagliabue E, Colombo D, Monacelli F, Braido F Abstract Chronic obstructive pulmonary disease (COPD) is generally considered to be prevalent in males. However, smoking is rising in women in developing and developed countries, while exposure to biomass fuel for domestic purposes is a recognized risk factor among females. Females developing more severe COPD patterns due to tobacco exposure than men maybe due to a genetic predisposition, a greater dose-dependent effect of smoke related to smaller airways caliber and an increased oxidative stress with augmented TGF-beta1 signaling. Ge...
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

3D-Printing: an emerging and a revolutionary technology in pharmaceuticals.
Authors: Singhvi G, Patil S, Girdhar V, Chellappan DK, Gupta G, Dua K Abstract One of the novel and progressive technology employed in pharmaceutical manufacturing, design of medical device and tissue engineering is threedimensional (3D) printing. 3D printing technologies provide great advantages in 3D scaffolds fabrication over traditional methods in the control of pore size, porosity, and interconnectivity. Various techniques of 3Dprinting include powder bed fusion, fused deposition modeling, binder deposition, inkjet printing, photopolymerization and many others which are still evolving. 3Dprinting technique bee...
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Role of miR-503 in gastric cancer.
Authors: Rosso C PMID: 29856180 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Doxycycline for Helicobacter pylori treatment.
Authors: Mladenova I PMID: 29856181 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Drug delivery to the CNS.
Authors: Khosa A, Singhvi G, Saha RN, Gupta G PMID: 29856182 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Hepatitis C virus-induced hepatocellular carcinoma: a narrative review.
Authors: Ružić M, Pellicano R, Fabri M, Luzza F, Boccuto L, Brkić S, Abenavoli L Abstract Hepatocellular carcinoma (HCC) is the most frequent primary liver carcinoma, accounting for about 80% of cases. In spite of advances in modern oncology, this neoplasia still holds the second place in overall cancer mortality. HCC is a multifactor disease: it results from accumulated oncogenic potentials made up of several groups of risk factors, the most significant of which is an infection with hepatotropic viruses. The Hepatitis C virus (HCV) is one of the primary causes of morbidity and mortality across the world and aff...
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Early or delayed bronchoscopy in patients admitted to the Emergency Department for mild-to-moderate haemoptysis?
CONCLUSIONS: In conclusion, in case of mild to moderate haemoptysis, an early bronchoscopy in the Emergency Department setting does not seem to improve the possibility to find neither the cause nor the localization of the bleeding source. PMID: 29856184 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Current updates on pharmacological roles of Glucagon-Like Peptide 1 (GLP-1) in obesity.
Authors: Kumar Verma R, Sriramaneni R, Pandey M, Chaudhury H, Gorain B, Gupta G PMID: 29856185 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - June 3, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Correlations of serum cystatin C and hs-CRP with vascular endothelial cell injury in patients with active systemic lupus erythematosus.
Authors: Gao D, Shao J, Jin W, Xia X, Qu Y Abstract BACKGROUND: To investigate the correlations of serum cystatin C and high-sensitivity C-reactive protein (hs-CRP) with vascular endothelial cell injury in patients with active systemic lupus erythematosus (SLE). METHODS: A total of 80 patients with SLE treated in our hospital from January 2016 to September 2017 were selected and randomly divided into stable-stage group (n=40) and active-stage group (n=40) using a random number table. The expressions of cystatin C and hs-CRPin stable and active stages were compared, and the inner diameters of brachial artery and...
Source: Panminerva Medica - May 26, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Temporary kidney dysfunction: Robuvit ® supplementation in initial, transient kidney insufficiency and micro-macro albuminuria.
Temporary kidney dysfunction: Robuvit® supplementation in initial, transient kidney insufficiency and micro-macro albuminuria. Panminerva Med. 2018 Jun;60(2):60-64 Authors: Ledda A, Belcaro G, Feragalli B, Hosoi M, Cacchio M, Luzzi R, Dugall M, Cotellese R, Cesarone MR Abstract BACKGROUND: The aim of this study was to evaluate the efficacy of Robuvit® (French oak extract, Horphag Research) in improving kidney function in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels. METHODS: Fifty-seven subjects with TKD were included in the registry. Subjects were ...
Source: Panminerva Medica - May 9, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Pycnogenol ® supplementation improves the control of irritable bowel syndrome symptoms.
This study included 77 healthy individuals with symptoms of IBS. The patients were divided into three groups: group 1 was treated with Buscopan (10 mg when needed), group 2 (Antispasmina col forte; 50 mg papaverine hydrochloride+10 mg belladonna extract when needed) and 3 (Pycnogenol® 150 mg/day) for 3 weeks. RESULTS: The number of painful attacks was comparable in all groups after four weeks. Mild pain on manual abdomen pressure was decreased in all groups, with the improvement in the Pycnogenol® group significantly more pronounced that in both control groups (P
Source: Panminerva Medica - May 9, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Reversible splenial lesion in neuroleptic malignant syndrome.
Authors: Gasparini A, Poloni N, Caselli I, Ielmini M, Callegari C PMID: 29696960 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Socio-economic status and the clinical acuity of emergency medical admissions.
Authors: Conway R, Byrne D, Cournane S, O'riordan D, Silke B PMID: 29696961 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Alpha1-antitrypsin deficiency: what's new after European Respiratory Society statement.
Authors: Patrucco F, Venezia L, Gavelli F, Pellicano R, Solidoro P Abstract Alpha-1 antitrypsin deficiency (AATD) is a clinically under-recognized inherited disorder affecting the lungs and the liver. The most common manifestations are pulmonary emphysema, bronchiectasis and liver disease. The recent publication of the European Respiratory Society statement on diagnosis and treatment of pulmonary diseases has replaced the 2003 American Thoracic Society and European Respiratory Society one. New outcome parameters have been introduced and validated by observational and randomized clinical trials, and new information ...
Source: Panminerva Medica - April 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation.
Authors: Pan J, Wang W, Wu X, Kong F, Pan J, Lin J, Zhang M Abstract BACKGROUND: To investigate the changes of inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation and the effects of metoprolol on them. METHODS: A total of 92 cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation in our hospital from April 2015 to March 2017 were selected and randomly divided into the control group and the observation group, with 46 cases in each group. Three months after pacemaker implantation, the control group was treated with aspirin, ...
Source: Panminerva Medica - April 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Current therapies and targets for type 2 diabetes mellitus: a review.
Authors: Chellapan DK, Sheng Yap W, Bt Ahmad Suhaimi NA, Gupta G, Dua K Abstract The prevalence of type 2 diabetes mellitus (T2DM) has been increasing at an alarming rate. With an increased understanding of the pathophysiology and pathogenesis of T2DM, various new therapeutic options have been developed to target different key defects in T2DM. Incremental innovations of existing therapies either through unprecedented drug combinations, modified drug molecules, or improved delivery systems are capable to nullify some of the undesirable side effects of traditional therapies as well as to enhance effectiveness. The ex...
Source: Panminerva Medica - April 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Clinical study on the efficacy, acceptance, and safety of hearing aids in patients with mild to moderate presbyacusis.
Authors: Romanet P, Guy M, Allaert FA Abstract BACKGROUND: of the study: The primary objective of this trial was to demonstrate the effect of wearing a Hearing aid (HA) on improvement of hearing and comprehension in everyday life situations. METHODS: This mono-centre phase IV open-label clinical trial was carried out on men or women 40 years old or more, presenting mild or moderate first-degree presbyacusis. Presbyacusis was diagnosed by performance of pure-tone audiometry in silence. The main criterion was the comparison of the Glasgow Hearing Aid Benefit Profile (GHABP) before wearing HA and after a month of ...
Source: Panminerva Medica - April 19, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Minimally invasive, ionizing-free, and ultrasound-guided technique to biopsy Anterior Mediastinal Masses (AMMs): first 60 cases.
Authors: Lorenzati B, Cristofori R, Landi A, Ruffini E, Novero D, Lauria G, Tartaglino BM, Oliaro A, Scaglione L, Rolfo E PMID: 29546737 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Multidimensional Prognostic Index (MPI) and Proadrenomedullin plasma levels in predicting one-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP): a prospective study.
CONCLUSIONS: ProADM may significantly improve the prognostic accuracy of the MPI at admission in hospitalized elderly patients with CAP. PMID: 29546738 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Non-invasive assessment of liver fibrosis: exploring the opportunity for a low-cost approach using the Genoa Line Quantification.
Authors: Marengo A PMID: 29546739 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Human factors study of ZENEO ® (needle-free autoinjector) and comparison of different user instruction formats.
CONCLUSIONS: The results show that the ZENEO® device can be effectively used with a conventional suite of printed user instructions. Use of a demonstration video provides additional value, whereas use of a dummy training device had limited value. PMID: 29508984 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 8, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Novel drug delivery approaches in treating pulmonary fibrosis.
Authors: Dua K, Awasthi R, Madan JR, Chellappan DK, Nalluri BN, Gupta G, Bebawy M, Hansbro PM PMID: 29480673 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - February 28, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Quantification of ultrasound imaging in the staging of hepatic fibrosis.
CONCLUSIONS: GQL has allowed a classification, which is well concordant with the ultrasound elastography data. The use of the GQL may also be developed within centers, which are not provided with ultrasound elastography techniques, when an ultrasound elastography examination cannot be performed due to technical problems and as a support to elastography, if the outcome of this examination is not sufficiently clear. PMID: 29442483 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - February 15, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Role of genetic and metabolism in non-alcoholic fatty liver disease.
Authors: Abenavoli L, Pellicano R, Boccuto L PMID: 29442484 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - February 15, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

High blood pressure, Alzheimer disease and antihypertensive treatment.
Authors: Marfany A, Sierra C, Camafort M, Domenech M, Coca A Abstract Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. AD represents 70% of all dementia cases, affecting up to 50% of elderly persons aged 85 or older, with functional dependence, poor quality of life, institutionalization and mortality. Advanced age is the main risk factor of AD, that's why population ageing, due to life expectancy improvements, increases AD incidence and prevalence, as well as the economic, social, and emotional costs associated with this illness. Existi...
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

A clinical update on metformin and lung cancer in diabetic patients.
Authors: Gupta G, de Jesus Andreoli Pinto T, Chellappan DK, Mishra A, Malipeddi H, Dua K Abstract Diabetes mellitus (DM) is frequently increased in many countries and become a serious health problem worldwide. Diabetes is associated with dysfunction of different organs such as heart, eyes, blood vessels, nerves, and kidneys. There is a strong connection between diabetes and cancer. Metformin is one of the most commonly prescribed oral antidiabetic medicines and it is suggested as the firstline therapy due to its comparatively safe, inexpensive, effective and welltolerated. Some of the in vitro and in vivo investiga...
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research