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Quantification of ultrasound imaging in the staging of hepatic fibrosis.
CONCLUSIONS: GQL has allowed a classification, which is well concordant with the ultrasound elastography data. The use of the GQL may also be developed within centers, which are not provided with ultrasound elastography techniques, when an ultrasound elastography examination cannot be performed due to technical problems and as a support to elastography, if the outcome of this examination is not sufficiently clear. PMID: 29442483 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - February 15, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Role of genetic and metabolism in non-alcoholic fatty liver disease.
Authors: Abenavoli L, Pellicano R, Boccuto L PMID: 29442484 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - February 15, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

High blood pressure, Alzheimer disease and antihypertensive treatment.
Authors: Marfany A, Sierra C, Camafort M, Domenech M, Coca A Abstract Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. AD represents 70% of all dementia cases, affecting up to 50% of elderly persons aged 85 or older, with functional dependence, poor quality of life, institutionalization and mortality. Advanced age is the main risk factor of AD, that's why population ageing, due to life expectancy improvements, increases AD incidence and prevalence, as well as the economic, social, and emotional costs associated with this illness. Existi...
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

A clinical update on metformin and lung cancer in diabetic patients.
Authors: Gupta G, de Jesus Andreoli Pinto T, Chellappan DK, Mishra A, Malipeddi H, Dua K Abstract Diabetes mellitus (DM) is frequently increased in many countries and become a serious health problem worldwide. Diabetes is associated with dysfunction of different organs such as heart, eyes, blood vessels, nerves, and kidneys. There is a strong connection between diabetes and cancer. Metformin is one of the most commonly prescribed oral antidiabetic medicines and it is suggested as the firstline therapy due to its comparatively safe, inexpensive, effective and welltolerated. Some of the in vitro and in vivo investiga...
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Current updates on biological and pharmacological activities of Doxycycline.
Authors: Devi B, Kumar Y, Shrivastav B, Sharma GN, Gupta G, Dua K PMID: 29370677 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Advancements in nano drug delivery systems: a challenge for biofilms in respiratory diseases.
Authors: Dua K, de Jesus Andreoli Pinto T, Chellappan DK, Gupta G, Bebawy M, Hansbro PM PMID: 29370678 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Fecal calprotectin: beyond intestinal organic diseases.
Authors: Caviglia GP, Ribaldone DG, Rosso C, Saracco GM, Astegiano M, Pellicano R Abstract Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clin...
Source: Panminerva Medica - January 27, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

New and emerging treatments for metastatic Merkel Cell Carcinoma.
Authors: Cestaro G, Quarto G, DE Monti M, Fasolini F, DE Fazio M, Furino E, Gentile M PMID: 29332376 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - January 16, 2018 Category: General Medicine Tags: Panminerva Med Source Type: research

Home blood pressure measurement as a systematic tool for clinical practice in CKD patients: a real-world picture.
CONCLUSIONS: We observed a quite high rate of masked uncontrolled hypertension and of white coat hypertension in stage 3-5ND CKD patients. Office BP measurement, as a single tool, is an inadequate diagnostic procedure in the clinical management of CKD patients. HBPM should be routinely implemented for identifying hypertensive phenotypes and then for avoiding misdiagnosis and mistreatment of pre-dialysis CKD patients in a tertiary care setting. PMID: 29164841 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - November 24, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Tumor suppressor role of miR-503.
Authors: Gupta G, Chellappan DK, de Jesus Andreoli Pinto T, Hansbro PM, Bebawy M, Dua K Abstract MicroRNAs (miRNAs) are noncoding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate posttranscriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR503, an associate of the "canonical" miRNA16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence...
Source: Panminerva Medica - November 24, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Relapse and cytogenetic evolution in myeloid neoplasms.
Authors: Ertz-Archambault N, Kelemen K Abstract Based on the current WHO Classification of Myeloid Neoplasms, cytogenetic findings play a central role in the diagnostic classification of the myeloid malignancies. Cytogenetic abnormalities detected at primary diagnosis may change over time. Karyotype changes can be characterized as cytogenetic evolution, cytogenetic regression or a combination of both. While the exact mechanism of cytogenetic evolution is not completely understood, the process of cytogenetic evolution is not random, but follows different, and often disease-specific patterns during progression and re...
Source: Panminerva Medica - November 17, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Role of microRNAs (miRNAs) in pathophysiology of diabetes mellitus.
Authors: Tiwari J, Gupta G, de Jesus Andreoli Pinto T, Sharma R, Pabreja K, Matta Y, Arora N, Mishra A, Sharma R, Dua K Abstract Diabetes Mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of ß cells within the pancreas. This disease becomes the leading cause of death so it is necessary to study the molecular pathogene...
Source: Panminerva Medica - November 14, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Research on the correlation between MMP gene polymorphism and susceptibility to cervical cancer in Chinese women.
Authors: Chen L, Qiang P, Shao Y PMID: 28994565 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - October 11, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Effects on cognitive function of propofol medium and long chain lipid emulsion in patients with hepatic encephalopathy.
Authors: Yu S, Hu J, Ding L, Yu D Abstract BACKGROUND: Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function of the patients with hepatic encephalopathy undergoing hemofiltration treatment. METHODS: A total of 87 patients diagnosed with hepatic encephalopathy from January 2014 to January 2016 were continuously selected, and randomly (Using Random number method) divided into an observation group (45 cases) and a control group (42 cases). All patients were treated with persistent hemofiltration; the patients in control group were not given any sedative m...
Source: Panminerva Medica - September 10, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

High peak PaO2 values are associated with adverse outcome in critically ill patients treated with non-invasive ventilation for acute cardogenic pulmonary edema and pneumonia.
Authors: Schernthaner C, Wernly B, Lichtenauer M, Franz M, Lauten A, Schulze PC, Kabisch B, Braun K, Muessig J, Masyuk M, Hoppe UC, Kelm M, Jung C Abstract BACKGROUND: Non-invasive Ventilation (NIV) has a sigificant impact on mortality in acute respiratory failure (ARF). Predictive parameters for mortality are of high interest. METHODS: We retrospectively analyzed 3759 blood gas analysis and clinical parameters of 475 patients presenting with ARF based on acute cardiogenic pulmonary edema and/or pneumonia. The influence of peak arterial oxygen partial pressure levels (PaO2) with respect to its predictive value ...
Source: Panminerva Medica - September 10, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Liver fibrosis: the 2017 state of art.
Authors: Caviglia GP, Rosso C, Fagoonee S, Saracco GM, Pellicano R Abstract Liver fibrosis is a wound-healing response to a wide spectrum of chronic liver injuries. It is characterized by loss of hepatocytes and alteration in hepatic architecture following an imbalance between extracellular matrix synthesis and degradation. Irrespectively of underlying etiology, fibrosis may progress to cirrhosis and specific pathogenetic mechanisms as well as different disease patterns may be identified according to etiology. Liver biopsy is still considered the gold standard for fibrosis assessment, despite the fact that it is in...
Source: Panminerva Medica - September 8, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Effects of family-centered care based on timing it right on the care ability and the quality of life of family members of patients with acute myocardial infarction.
Authors: Xu M, Han D, Wang X, Yu X, Hao W, Zhu D PMID: 28880054 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - September 8, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Analysis of medium-long-term therapeutic effect of PCM artificial cervical disc replacement.
Authors: Li H, Weng Y, Zhou D, Nong L, Xu N PMID: 28752986 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - July 30, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

New serum markers for detection of early hepatocellular carcinoma.
Authors: Abenavoli L, Boccuto L PMID: 28714299 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - July 19, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

How to interpret meta-analysis results.
Authors: Ribaldone DG, Petrini E PMID: 28665097 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - July 2, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Food supplements, stress and gastrointestinal diseases.
Authors: Ribaldone DG, Saracco GM PMID: 28665098 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - July 2, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Improvement in behavioral and psychological symptoms of dementia by rivastigmine patch in a group of Italian elderly patients with Alzheimer's disease.
Authors: Servello A, Ettorre E, Cacciafesta M PMID: 28665099 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - July 2, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Nanotechnology: potential tool for immunology.
Authors: Aslam B, Nisar MA, Khurshid M, Muzammil S, Hayat S PMID: 28665100 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - July 2, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

UCA1 lncRNA in metastases and prognosis.
Authors: Song W, Wang K, Zou SB PMID: 28665101 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - July 2, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Risk of hepatocellular carcinoma in HBV cirrhotic patients assessed by the combination of miR- 122, AFP and PIVKA-II.
Authors: Caviglia GP, Abate ML, Gaia S, Petrini E, Bosco C, Olivero A, Rosso C, Ciancio A, Pellicano R, Saracco GM, Rizzetto M, Smedile A Abstract BACKGROUND: Reliable biomarkers for early detection of hepatocellular carcinoma (HCC) in patients with cirrhosis are lacking. We evaluated the use of miR-122, alpha-fetoprotein (AFP) and protein induced by vitamin k absence/antagonist II (PIVKA-II) for HCC risk prediction in patients with HBV-related cirrhosis under surveillance. METHODS: We first analyzed a group of 63 patients with HBV-related liver cirrhosis of whom 33 had HCC. Then we performed a retrospective an...
Source: Panminerva Medica - June 27, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Cardiovascular consequences of hypophosphatemia.
CONCLUSIONS: The mechanisms of hypophosphatemia in cardiomyopathy and arrhythmia have been reported to be a depletion of adenosine triphosphate in myocardial cells and decreased 2,3-diphosphoglycerate in erythrocytes. Left ventricular performance seems to improve when severe hypophosphatemia is corrected, but not in those with mild to moderate hypophosphatemia. However, analyses of the relationship between cardiac function and hypophosphatemia using clinical end points have not been conducted. The association between hypophosphatemia and arrhythmia remains unclear, but anecdotal reports exist in the literature. PMID: 2...
Source: Panminerva Medica - May 14, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Catastrophic antiphospholipid syndrome: an update.
Authors: Espinosa G, Rodriguez-Pinto I, Cervera R Abstract Catastrophic antiphospholipid syndrome (CAPS) is a rare variant that accounts for 1% of patients with APS. Despite its low frequency, the mortality-related is very high ranging from 50% of patients in the first series to 37% in the most recent data. The current knowledge of this potential devastating entity comes from the International Registry of patients with CAPS, named CAPS Registry. Small vessel thrombosis, laboratory features of microangiopathic haemolytic anemia, and development of multisystem involvement in a very short period of time are the main c...
Source: Panminerva Medica - May 12, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Sleep-disordered breathing in heart failure patients after ventricular assist device implantation and heart transplantation.
Authors: Chowdhury A, Mathew R, Castriotta RJ Abstract Chronic heart failure (CHF) represents a major health and economic burden and is associated with high rates of hospital admission, morbidity, mortality and decreased quality-adjusted life years. New advances in the treatment of CHF such as ventricular assist devices (VADs) and heart transplantation have helped improve outcomes. Sleep-disordered breathing (SDB) is highly prevalent in CHF patients and the associated morbidity makes it essential for physicians to be more cognizant about its existence, interaction and need for treatment. This is a review of what is...
Source: Panminerva Medica - May 12, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

HOTAIR and gastric cancer: a lesson from two meta-analyses.
Authors: Fagoonee S, Durazzo M PMID: 28488843 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 12, 2017 Category: General Medicine Tags: Panminerva Med Source Type: research

Heart failure and role of circulating MMP-2 and MMP-9.
Authors: Radosinska J, Barancik M, Vrbjar N Abstract The myocardial extracellular matrix (ECM) is the dynamic environment that is fundamental for the structural and physiological homeostasis of the heart. Alterations in ECM homeostasis may lead to diastolic or systolic dysfunction and consequent development of heart failure (HF). For degradation of ECM, matrix metalloproteinases (MMPs) are responsible. To the most frequently analyzed MMPs in relation to HF syndrome belong MMP-2 and MMP-9. This review summarizes the recent knowledge concerning the role of circulating MMP-2 and MMP-9 (i.e. those that can be determine...
Source: Panminerva Medica - April 14, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Conservative management of chronic kidney disease: how to avoid or defer dialysis.
Authors: Bolasco P, Kalantar-Zadeh K, Rhee C PMID: 28290185 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Phosphorus and other aspects of CKD-MBD in the conservative management of chronic kidney disease.
Authors: Shah A Abstract As the prevalence of chronic kidney disease (CKD) increases and the population ages, there is an imperative to offer cost effective and patient specific therapeutic options for the management of advanced CKD. In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies for delaying the need for renal replacement therapy should be offered. CKD-mineral bone disorders (MBD) refers to the constellation of disturbances in abnormal bone and soft tissue calcification along with abnormalities, in phosphorus, calcium, parathyroi...
Source: Panminerva Medica - March 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Which first-line treatment in Piedmont in the year 2017?
Authors: Berrutti M, Leone N PMID: 28290187 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Vaccine as absolute solution of Helicobacter pylori infection.
Authors: Talebi Bezmin Abadi A PMID: 28290188 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Helicobacter pylori 2017: revitalized therapies for an ever-challenging bug.
Authors: Actis GC PMID: 28290189 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - March 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Prognostic factors in 1080 prostate cancer patients treated by radical external beam radiotherapy.
CONCLUSIONS: Our results confirm prognostic factors described by literature, adding as new prognostic factor the rectal/bladder preparation, generally known for its effect on toxicity but not yet on outcome. PMID: 28256120 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 4, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Neutrophil lymphocyte ratio better addition to CRP than CD64 index as marker for infection in COPD.
This study investigated the importance of neutrophil-lymphocyte ratio (NLR) and other new inflammatory markers including CD64 expression in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation and infection. METHODS: 72 patients with a diagnosis of COPD exacerbation who were admitted to Internal Medicine B department, 13 stable COPD, and control group of 15 healthy persons were enrolled in the study. Complete blood count (CBC), measurement of C reactive protein (CRP), MPV, RDW and CD64 expression were determined within 2 hours of h...
Source: Panminerva Medica - February 12, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

The first-line treatment of Helicobacter pylori infection in Piedmont in the year 2017.
Authors: Pellicano R, Ribaldone DG, Fagoonee S, Astegiano M, Saracco GM PMID: 28094491 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - January 19, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Use of ace-inhibition and blood pressure management in deferring dialysis initiation.
Authors: Del Vecchio L, Teatini U, Locatelli F Abstract Elevated blood pressure is one of the most significant risk factor for the development of chronic kidney disease (CKD); its treatment is a milestone in CKD management. While it is accepted that a stricter blood pressure control is indicated in patients with proteinuria or microalbuminuria, the exact degree of blood pressure reduction to be obtained in CKD patients is still under debate. Following more recent interpretation of old trials, a BP target for
Source: Panminerva Medica - January 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Sodium and fluid management in the conservative management of Chronic Kidney Disease.
Authors: Marcuccilli M, Kendrick J, Chonchol M Abstract Chronic kidney disease (CKD) imposes a significant global health burden. In the United States, one in three adults are at risk for CKD currently affecting over 28 million Americans. While several studies have demonstrated the benefit of treating traditional risk factors in CKD, including hypertension with pharmacologic agents such as blockade of the renin-angiotensin system (RAAS), there is scarce data on the advantages of sodium and fluid management in this population. Both experimental and observational studies have shown improvement in hypertension and card...
Source: Panminerva Medica - January 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Incremental and infrequent hemodialysis: a new paradigm for both dialysis initiation and conservative management.
Authors: Rhee CM, Ghahremani-Ghajar M, Obi Y, Kalantar-Zadeh K Abstract Registry or national dialysis data show that a sizeable proportion of contemporary dialysis patients have substantial levels of residual kidney function especially upon transitioning to dialysis therapy. However, among incident hemodialysis patients, the prevailing paradigm has been to initiate "full-dose" thrice-weekly treatment schedules irrespective of native kidney function in most developed countries. Recognizing the benefits of residual kidney function upon the health and survival of dialysis patients, there has been growing int...
Source: Panminerva Medica - January 17, 2017 Category: Journals (General) Tags: Panminerva Med Source Type: research

Modified Glasgow prognostic score might be a prognostic factor for hepatocellular carcinoma: a meta-analysis.
CONCLUSIONS: In conclusion, this meta-analysis suggested that mGPS might be an independent prognostic factor for HCC. PMID: 28001023 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - December 23, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Microbiota and prebiotics modulate uremic toxins generation.
Authors: Koppe L, Fouque D Abstract Recent data have shown that the host-intestinal microbiota interaction is intrinsically linked with overall health. Chronic kidney disease (CKD) could influence intestinal microbiota and gut dysbiosis is also considered as a cause of progression of kidney disease. An increasing body of evidence indicates that dysbiosis is a key contributor of uremic retention solutes (URS) accumulating in patients with CKD. The discovery of the kidney- gut axis has created new therapeutic opportunities for nutritional intervention in order to prevent adverse outcomes. One of these strategies is p...
Source: Panminerva Medica - December 23, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Clinical benefits of phosphate control in progression of end stage renal disease.
Authors: Bolasco P, Murtas S Abstract It is largely agreed that preservation of RKF has a directly proportional affect on general, and in particular cardiovascular, mortality. During evaluation of patients on infrequent hemodialysis (ID) as both as once-weekly or twice-weekly hemodialysis it has been frequently underestimated the importance of phosphaturia, Indeed, the native kidney preserves the ability to eliminate not only toxic molecules but also a significative output of phosphate despite of a severe decrease of residual kidney function (RKF). This task the modern membranes are as yet not very efficient of rep...
Source: Panminerva Medica - December 23, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Keto-analogues and essential amino acids and other supplements in the conservative management of chronic kidney disease.
Authors: Cupisti A, Bolasco P Abstract The manipulation of dietary protein intake is the mainstay of nutritional treatment of patients affected by chronic renal insufficiency, with an aim to reduce the burden of uremic toxins in order to decrease uremic toxicity and delay the need for dialysis. Consensus exists regarding the benefit of progressive protein restriction towards delaying the progression of renal failure and the need for dialysis, provided adequate energy supply. Although pivotal, protein restriction is only one aspect of the dietary management of CKD patients. Additional features, though strictly relat...
Source: Panminerva Medica - December 23, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

The role of carbon adsorbent in the conservative management of chronic kidney disease.
Authors: Niwa T Abstract Indoxyl sulfate is a uremic toxin, and cannot be removed efficiently by hemodialysis due to its protein-binding. Indoxyl sulfate induces cellular dysfunction by producing reactive oxygen species (ROS) such as superoxide by activating nicotinamide adenine dinucleotide phosphate oxidase, and by activating aryl hydrocarbon receptor through its uptake via organic anion transporters (OAT1 and OAT3). Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular cells, glomerular mesangial cells, vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, c...
Source: Panminerva Medica - December 20, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Delphinol ® standardized maqui berry extract significantly lowers blood glucose and improves blood lipid profile in prediabetic individuals in three-month clinical trial.
CONCLUSIONS: Our findings point to considerable health potentials benefits of Delphinol, particularly related to the improvement of glucose metabolism. Delphinol® was well tolerated and no adverse effects occurred. PMID: 27820958 [PubMed - in process] (Source: Panminerva Medica)
Source: Panminerva Medica - November 10, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

A design thinking approach to primary ovarian insufficiency.
Authors: Martin LA, Porter AG, Pelligrini VA, Schnatz PA, Jiang X, Kleinstreuer N, Hall JE, Verbiest S, Olmstead J, Fair R, Falorni A, Persani L, Rajkovic A, Mehta K, Nelson LM Abstract Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and manage...
Source: Panminerva Medica - November 10, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Contemporary techniques for coronary CTO revascularization: an update.
Authors: Dedovic V, Stankovic G Abstract Despite permanent improvement in success rate and technical developments, chronic total occlusion (CTO) remains undertreated by percutaneous coronary intervention (PCI). Dedicated CTO operators from Japan, Europe and USA perform these procedures with success rate beyond 90%, but there is still huge gap between this group of specialists and broader population of PCI operators. Recently proposed CTO scores can be used for patients' selection according to the CTO operators' experience. Patients with low CTO score values may be suitable for less experienced operators at the begi...
Source: Panminerva Medica - October 22, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

The role of low protein diet in ameliorating proteinuria and deferring dialysis initiation: what is old and what is new.
Authors: Wang M, Chou J, Chang Y, Lau WL, Reddy U, Rhee CM, Chen J, Hao C, Kalantar-Zadeh K Abstract In the management of patients with chronic kidney diseases (CKD), a low-protein diet usually refers to a diet with protein intake of 0.6 to 0.8 grams per kilogram of body weight per day (g/kg/day) and should include at least 50% high-biologic-value protein. It may be supplemented with essential acids or nitrogen- free ketoanalogues if
Source: Panminerva Medica - October 22, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research