The vaccine journey for COVID-19: a comprehensive systematic review of current clinical trials in humans.
CONCLUSIONS: This new disease is pushing the scientific community to develop swiftly a safe and effective vaccine. Notwithstanding the limitations of our analysis, given by the absence of available results, we try to provide a comprehensive view of the ongoing clinical trials in humans. Our analysis reveals a worldwide effort of both scientists and enterprises to achieve one of the most challenging goals of our century. PMID: 32456404 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 29, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Predictors of endoscopic intervention in upper gastrointestinal bleeding patients hospitalized for another illness: a multi-center retrospective study.
CONCLUSIONS: In hospitalized patients, in case of de novo NVUGIB, the number of PRBC units transfused and RS are predictive of significant endoscopic findings. PMID: 32432444 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 22, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

The kidney in COVID-19: protagonist or figurant?
Authors: Staico MF, Zaffanello M, Di Pietro G, Fanos V, Marcialis MA Abstract The etiology of injury in COVID-19 patients is diverse and multifactorial. Autopsy and biopsy studies reveal, alongside podocyte and tubular cell anomalies, the presence of virion within the cells. Evidence suggests that, in addition to the direct cytopathic effect of SARS- CoV2 on the glomeruli and renal tubules, there is also the indirect effect of cell-mediated immunity, the cytokines storm and the cross-talk between organs with possible systemic effects of the disease. These mechanisms are interconnected and have profound therapeutic ...
Source: Panminerva Medica - May 22, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1.
CONCLUSIONS: HOXD9 is upregulated in cervical cancer species. Its level is closely linked to metastasis rate and poor prognosis in cervical cancer patients. Through positively regulating HMCN1 level, HOXD9 stimulates migratory and invasive capacities in cervical cancer cells. PMID: 32414224 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

The evaluation of meticulous and humanized nursing management mode on patient's physiology, psychology and comfort level as well as the incidence of adverse events in operating room.
Authors: Cong C, Zhan L, Song P, Pan Z, Chen J PMID: 32414225 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor- α-induced protein 8.
CONCLUSIONS: MiR-379 has a binding site with TNFAIP8 and can inhibit its activity by binding to TNFAIP8 mRNA. SiRNA-TNFAIP8 can inhibit the NF-κB signaling pathway and protect myocardial cells from AMI-induced myocardial damage by reducing the apoptosis level of myocardial cells. PMID: 32414226 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Activation of TGR5 receptor reduces damage of ET-1 on H9C2 cardiomyocytes by activating Nrf2.
CONCLUSIONS: Activation of TGR5 receptor may reduce the damage of ET-1 on H9C2 cardiomyocytes by activating Nrf2 and its downstream antioxidant genes HO-1, NQO-1 and Txnrd-1. PMID: 32414227 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Efficacy of conversion surgery on stage IV gastric cancer and its prognosis analysis.
Authors: Zhao Z, Fan Y, Sun Y, Xu F, Shen S Abstract BACKGROUND: To explore the clinical efficacy and safety of conversion surgery in the treatment of stage IV gastric cancer, and to analyze the influencing factors for the prognosis of patients. METHODS: The clinical data of 84 patients with stage IV gastric cancer treated in our hospital from September 2014 to March 2016 were collected. All patients were treated with S-1 + oxaliplatin or S-1 + docetaxel chemotherapy, among which 42 patients had surgical indications after chemotherapy and received gastrectomy (R0 resection or R1 resection) (conversion surgery g...
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Application of psychological suggestion therapy in induced labor of mid-late pregnant women in obstetrics.
Authors: Wang Z, Jia X, An R PMID: 32414229 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Gynecological prevention and control model based on ward rearrangement and zoning management in pandemic period of COVID-19.
Authors: Liu J, Yang J, Li S, Chen J, Yang L, Zhao Z, Hong L Abstract By 25th April 2020, the outbreak of COVID-19 caused 2719897 confirmed cases and 187705 deaths globally, remarkably more than Severe Acute Respiratory Syndrome (SARS) (8273 cases, 775 deaths) and Middle East Respiratory Syndrome (MERS) (1139 cases, 431 deaths) in 2003 and 2013, respectively. Gynecology is a specialty department with a large number of critical and severe patients. Consequently, it is of preeminent importance to formulate the in-patient management process. Rearranging the gynecological wards and managing ward partition, as well as t...
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

MicroRNA-1271-5p inhibits the tumorigenesis of ovarian cancer through targeting E2F5 and negatively regulates the mTOR signaling pathway.
CONCLUSIONS: MiR-1271-5p inhibited the tumorigenesis of OC through targeting E2F5 and negatively regulated the mTOR signaling pathway. PMID: 32414231 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Episiotomy: a medicolegal vicious cycle.
Authors: Zaami S, Zupi E, Lazzeri L, Centini G, Stark M, Malvasi A, Signore F, Marinelli E Abstract The present study aims to analyze the litigation trends and ensuing compensatory damages brought about by the use of episiotomy, in order to outline a set of cautionary rules meant to limit the scope of legal aftermath for both doctors and health care facilities. The authors have set out to gain an insight into the controversial practice of episiotomy, in light of available research data and official positions of various scientific and medical associations, with a close focus on the legal and medical viability of the...
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Coronavirus disease 2019 outbreak: liver disease a prognostic tool?
Authors: Testino G, Fagoonee S PMID: 32414233 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

MiR-99b regulates cerebral ischemia neuronal injury through targeting IGF1R.
CONCLUSIONS: MiR-99b promoted the viability and suppressed apoptosis of SH-SY5Y cells under OGD/R conditions through targeting IGF1R. PMID: 32343508 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 30, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Efficacy of statin therapy in chronic obstructive pulmonary disease: a systematic review and meta-analysis from 2008-2019.
CONCLUSIONS: Clinical trials conducted over a 10-year period revealed beneficial advantages of statin therapy in COPD patients, permitting increased exercise capacity, FEV1/FVC and HDL. In addition, CRP, IL-6, systolic blood pressure, SGRQ scores and CAT were significantly decreased as well as lipid levels. PMID: 32343509 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 30, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

COVID-19: are T lymphocytes simply watching?
Authors: Saverino D PMID: 32343510 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 30, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

How to manage rheumatic patients during the coronavirus pandemic.
Authors: Parisi S, Ditto MC, Finucci A, Fusaro E PMID: 32343511 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 30, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

MiR-101 inhibits proliferation and invasion abilities of SKOV-3 ovarian Ccncer cells.
Authors: Li Y, Li G, Wang X, Tang H, Geng N PMID: 32329329 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 26, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Beyond the growth delay in children with sleep-related breathing disorders: a systematic review.
CONCLUSIONS: The current systematic review demonstrates a scarcity of high quality studies on growth delay in children with sleep-disordered breathing. Significant catch-up growth after surgery in the short term and changes in IGF-1, IGFBP-3, ghrelin, and leptin levels has been reported in most published studies. PMID: 32329330 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 26, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Anesthetic effect of sevoflurane in the craniotomy hematoma evacuation treatment of hypertensive cerebral hemorrhage.
Authors: Zhang L, Wang X, Ge Y PMID: 32329331 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 26, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Clinical significance of plasma cortisol and adrenocorticotropic in coronary artery spasm syndrome.
Authors: Wu Q, Chen T, Shi P, He Z, Shen X, Fang K PMID: 32329332 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 26, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Emergency contraception: unresolved clinical, ethical and legal quandaries still linger.
Authors: Zaami S, Signore F, Baffa A, Votino R, Marinelli E, Del Rio A Abstract Emergency contraception (EC) has been prescribed for decades, in order to lessen the risk of unplanned and unwanted pregnancy following unprotected intercourse, ordinary contraceptive failure, or rape. EC and the linked aspect of unintended pregnancy undoubtedly constitute highly relevant public health issues, in that they involve women's self-determination, reproductive freedom and family planning. Most European countries regulate EC access quite effectively, with solid information campaigns and supply mechanisms, based on various reco...
Source: Panminerva Medica - April 26, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Novel cardiovascular biomarkers in patients with cardiovascular diseases undergoing intensive physical exercise.
CONCLUSIONS: The significant increase of sST2 after four weeks might be a short-term effect due to the mechanical strain caused by the high-intensity training program, whereas the increase in IGF-BP2 after four weeks and eight months is likely a result of metabolic changes due to physical exercise. PMID: 32309918 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 22, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Two cases of painless aortic dissection with neurological symptoms.
Authors: Fan G PMID: 32309919 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 22, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Study on the effect of evidence-based nursing model on quality of life and nursing satisfaction of patients with severe acute pancreatitis.
Authors: Zhang H, Chen C PMID: 32309920 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 22, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Serum CD59: a novel biomarker of idiopathic pulmonary fibrosis?
Authors: Cameli P, Bergantini L, D'alessandro M, Vietri L, Cameli M, Sestini P, Bargagli E Abstract BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is the most common among idiopathic interstitial pneumonia. Life expectancy is estimated around 3-5 years at diagnosis. No reliable prognostic biomarker has been approved for routinary clinical practice of IPF. The aim of this study is to investigate the potential prognostic value of serum CD59 in a cohort of IPF patients. METHODS: 57 patients (45 males, 66.1 ± 10 years old) were recruited in Siena Regional Referral Centre for Interstitial Lung Disease and un...
Source: Panminerva Medica - April 16, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

LncRNA SND1-IT1 is involved in rat myocardial ischemia/reperfusion injury via regulating miR-183-5p.
Authors: Xu X, Ma S, Liu Y PMID: 32290642 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 16, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Experience summary of a COVID-19 designated community hospital and its operation model.
CONCLUSIONS: We have achieved excellent results in the prevention and control stratagems implemented in this new community-designated hospital that specializes in treating patients with COVID-19. Its diagnosis and treatment model has completed the treatment of COVID- 19 patients successfully. After adjustment, this community hospital can shoulder the critical task of being a designated hospital for COVID-19, which includes admission, isolation, and therapy of suspected and mild COVID-19 patients, reducing the medical burden of superior hospitals. Furthermore, our experience provides concepts for community hospitals to temp...
Source: Panminerva Medica - April 16, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Dexmedetomidine alleviates lung injury in sepsis mice through regulating P38 MAPK signaling pathway.
Authors: Shao Y, Chen X, Liu Y, Chen X, Li C, Wang L, Zhao W PMID: 32231179 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

MiR-132 represses sepsis-induced myocardial injury in rats by regulating SIRT1 expression.
Authors: Zhang X, Liu N, Shao Y, Jiang T, Cui C, Chen X PMID: 32231180 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Clinical significance of PAX5 in lung adenocarcinoma and its role in cell proliferation and metastasis.
Authors: Wang X, Sun H, Song H, Sun W, Zhao P, Zhang T, Ma X PMID: 32231181 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Inhibition of has-miRNA-95 expression can improve the radiosensitivity of cervical cancer cells.
Authors: Zhong W, Zhao C, He X, Li Z PMID: 32231182 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Resveratrol inhibits Treg/Th17 mediated tumor immune escape in mice with cervical cancer.
Authors: Ge J, Ge X, Li H PMID: 32231183 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Study on the effect of nursing intervention combined with traditional Chinese and Western Medicine on the treatment of children's acute diarrhea.
Authors: Xu H, Yang J, Liu Y PMID: 32231184 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - April 3, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Application of DFA in research on the effect of horseback riding therapy on postural control complexity of hemiplegic patients.
Authors: Zhai X, Zhang X, Yin Q, Zhang H PMID: 32208406 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

An unusual presentation of merkel cell carcinoma at buttock: a case report and literature review.
Authors: Li X, Bo H, Tao J, Sun J, Zhao Y PMID: 32208407 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Type 3 diabetes (Alzheimer's disease): new insight for promising therapeutic avenues.
Authors: Candasamy M, Elhassan SA, Bhattamisra SK, Wong YH, Lim MS, Busthamin NA, Mohamad Ilni NB, Ng SS, Lim B, Ng SY, Ng WY Abstract Alzheimer's disease (AD) and type 2 diabetes mellitus (T2D) are two of the most commonly occurring diseases worldwide, especially among the elderly population. In particular, the increased prevalence of AD has imposed tremendous psychological and financial burdens on society. Growing evidence suggests both AD and T2D share many similar pathological traits. AD is characterized as a metabolic disorder whereby the glucose metabolism in the brain is impaired. This closely resembles the ...
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Research progress on the mechanism of NMDA receptor in Parkinson's disease.
Authors: Liu H, Liu M, Zhang S, Li W, Wang A, Yang F, Jiang H PMID: 32208409 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

TGF- β1 polymorphism in postmenopausal osteoporosis.
TGF-β1 polymorphism in postmenopausal osteoporosis. Panminerva Med. 2020 Mar 23;: Authors: Zhong L, Fu H, Song Y, Li H, Xu Q, Jia X PMID: 32208410 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Heart disease in patients suffering from alcohol related liver disease.
Authors: Testino G, Leone S, Pellicano R PMID: 32208411 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Coronavirus disease 2019 outbreak.
Authors: Patrucco F, Gavelli F, Shi R, De Vita N, Pavot A, Castello LM, Ravanini P, Balbo PE PMID: 32208412 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 27, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Keloidal penile fibrosis: improvements with Centellicum ® (Centella asiatica) and Pycnogenol® supplementation: a pilot registry.
Keloidal penile fibrosis: improvements with Centellicum® (Centella asiatica) and Pycnogenol® supplementation: a pilot registry. Panminerva Med. 2020 Mar;62(1):13-18 Authors: Ledda A, Cornelli U, Belcaro G, Dugall M, Feragalli B, Cotellese R, Hu S, Corsi M Abstract BACKGROUND: The aim of this pilot study was to evaluate the effects of Pycnogenol® and CA (Centellicum®) on penile fibrosis and on associated signs and symptoms. METHODS: A group of 82 subjects with penile nodules and plaques was included in this registry study and followed up for 3 months; 32 were managed with standard ma...
Source: Panminerva Medica - March 24, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Effectiveness of two high frequency chest wall oscillation techniques in patients with bronchiectasis: a randomized controlled preliminary study.
CONCLUSIONS: The two machines have improved health and quality of life scores in patients with bronchiectasis. RespIn 11 also demonstrated a significant lowering of exacerbations and a better patient acceptance. PMID: 32192317 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

The use of off-label medicines in Poland.
Authors: Patryn R, Bułaś L, Drozd M, Nieradko A PMID: 32192318 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Pirfenidone in chronic lung allograft dysfunction: a single cohort study.
CONCLUSIONS: Our CLAD patients treated with pirfenidone showed a good safety profile, similarly to that reported for IPF patients. The drug showed potential for stabilizing decline in respiratory function. Further studies are needed in order to draw conclusions about the effectiveness of this therapy. PMID: 32192319 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Combined effects of probiotic and chondroprotector on the expression of TLR-2, TLR-4, TNF- α and NF-κB in articular cartilage, subchondral bone and synovial membrane during osteoarthritis in rats.
CONCLUSIONS: The outcomes of our research prove that ChPs amplify the positive action of LPs in OA attenuation. PMID: 32192320 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Adriamycin inhibits proliferation and promotes apoptosis of gastric cancer cells through TGF- β/MAPK signaling pathway.
Adriamycin inhibits proliferation and promotes apoptosis of gastric cancer cells through TGF-β/MAPK signaling pathway. Panminerva Med. 2020 Mar 19;: Authors: Li K PMID: 32192321 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Efficacy of hypofractionated radiotherapy combined with docetaxel in middle and advanced non-small cell lung cancer and its effects on serum MMP-9 and VEGF expressions.
Authors: Chen X, Cui S, Zhang X, Cui N, Cui C, Wang L, Shao Y PMID: 32192322 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

The differential ultrasonic diagnosis of ovarian endometriosis and ovarian cancer.
Authors: Deng H, Lou R PMID: 32192323 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research

Therapeutic effect of bevacizumab combined with chemotherapy in patients with platinum-resistant ovarian cancer and its effect on vascular cell adhesion molecule 1 and FBXW7.
Authors: Du Z, Liu X, Pan X PMID: 32192324 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Source: Panminerva Medica - March 21, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research