Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells
CONCLUSIONS: These results suggest that hUMSCs-Exs could be a promising anti-inflammatory agent to regulate T-cell responses in EAE and other autoimmune diseases. However, further research is necessary to fully understand the underlying mechanisms and Lag-3's precise role in these conditions.PMID:38627337 | DOI:10.1007/s11033-024-09433-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Adel Mohammadzadeh Masoud Lahouty Hamed Charkhian Arash Adamnejad Ghafour Sahand Moazzendizaji Jafar Rezaei Shahriar Alipour Vahid Shafiei Irannejad Mohammad Hassan Khadem Ansari Source Type: research
Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells
CONCLUSIONS: These results suggest that hUMSCs-Exs could be a promising anti-inflammatory agent to regulate T-cell responses in EAE and other autoimmune diseases. However, further research is necessary to fully understand the underlying mechanisms and Lag-3's precise role in these conditions.PMID:38627337 | DOI:10.1007/s11033-024-09433-5 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 16, 2024 Category: Molecular Biology Authors: Adel Mohammadzadeh Masoud Lahouty Hamed Charkhian Arash Adamnejad Ghafour Sahand Moazzendizaji Jafar Rezaei Shahriar Alipour Vahid Shafiei Irannejad Mohammad Hassan Khadem Ansari Source Type: research
Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis
Clin Exp Immunol. 2024 Apr 16:uxae032. doi: 10.1093/cei/uxae032. Online ahead of print.ABSTRACTAltered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (RRMS) and are linked to disease progression and treatment responses. CD4+ T cells are pathogenic in RRMS, and defective T cell function could be mediated in part by liver X receptors (LXRs) - nuclear receptors that regulate lipid homeostasis and immunity. RNA-sequencing and pathway analysis identified that genes within the 'lipid metabolism'...
Source: Clinical and Developmental Immunology - April 16, 2024 Category: Allergy & Immunology Authors: Lucia Martin-Gutierrez Kirsty E Waddington Annalisa Maggio Leda Coelewij Alexandra Oppong Nina Yang Marsilio Adriani Petra Nytrova Rachel Farrell In és Pineda-Torra Elizabeth C Jury Source Type: research
Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis
Clin Exp Immunol. 2024 Apr 16:uxae032. doi: 10.1093/cei/uxae032. Online ahead of print.ABSTRACTAltered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (RRMS) and are linked to disease progression and treatment responses. CD4+ T cells are pathogenic in RRMS, and defective T cell function could be mediated in part by liver X receptors (LXRs) - nuclear receptors that regulate lipid homeostasis and immunity. RNA-sequencing and pathway analysis identified that genes within the 'lipid metabolism'...
Source: Clinical and Developmental Immunology - April 16, 2024 Category: Allergy & Immunology Authors: Lucia Martin-Gutierrez Kirsty E Waddington Annalisa Maggio Leda Coelewij Alexandra Oppong Nina Yang Marsilio Adriani Petra Nytrova Rachel Farrell In és Pineda-Torra Elizabeth C Jury Source Type: research
Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis
Clin Exp Immunol. 2024 Apr 16:uxae032. doi: 10.1093/cei/uxae032. Online ahead of print.ABSTRACTAltered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (RRMS) and are linked to disease progression and treatment responses. CD4+ T cells are pathogenic in RRMS, and defective T cell function could be mediated in part by liver X receptors (LXRs) - nuclear receptors that regulate lipid homeostasis and immunity. RNA-sequencing and pathway analysis identified that genes within the 'lipid metabolism'...
Source: Clinical and Developmental Immunology - April 16, 2024 Category: Allergy & Immunology Authors: Lucia Martin-Gutierrez Kirsty E Waddington Annalisa Maggio Leda Coelewij Alexandra Oppong Nina Yang Marsilio Adriani Petra Nytrova Rachel Farrell In és Pineda-Torra Elizabeth C Jury Source Type: research
Pediatric traumatic brain injury and early age multiple sclerosis in Finland: A nationwide register ‐based cohort study
There is no evidence of an association between pediatric traumatic brain injuty (pTBI) and early-onset multiple sclerosis 20 years post-initial trauma.Hazard ratio (HR) for pTBI was 1.10 (95% CI: 0.56-1.48). AbstractObjectiveExamine the link between pediatric traumatic brain injury (pTBI) and early-onset multiple sclerosis in Finland.MethodsConducted nationwide register study (1998 −2018) with 28,750 pTBI patients (< 18) and 38,399 pediatric references with extremity fractures. Multiple sclerosis diagnoses from Finnish Social Insurance Institution. Employed Kaplan−Meier and multivariable Cox regression for probabi...
Source: Brain and Behavior - April 16, 2024 Category: Neurology Authors: Juho Laaksonen,
Ville Ponkilainen,
Ilari Kuitunen,
Julius M öttönen,
Ville M. Mattila Tags: ORIGINAL ARTICLE Source Type: research
Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis
ConclusionsCertain DMTs have the potential to positively impact QoL of PwMS, and the assessment and reporting of QoL is suboptimal with a multitude of diverse instruments being used. There is an urgent need that design and reporting of clinical trials reflect the critical importance of QoL for PwMS. (Source: Journal of Neurology)
Source: Journal of Neurology - April 16, 2024 Category: Neurology Source Type: research
Influence of manipulative skills on quality of life and activities of daily living in multiple sclerosis
CONCLUSIONS: The findings of this study point to the fact that patients diagnosed with multiple sclerosis have a decrease in prey strength, pinch strength, manipulative dexterity, quality of life and autonomy in activities of daily living compared to the healthy population.PMID:38618668 | DOI:10.33588/rn.7808.2023297 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: S Rodr íguez-Menéndez R M Mart ínez-Piédrola M Men éndez-González M P érez-de-Heredia-Torres Source Type: research
Revolutionizing Neurological Disorder Treatment: Integrating Innovations in Pharmaceutical Interventions and Advanced Therapeutic Technologies
Curr Pharm Des. 2024 Apr 9. doi: 10.2174/0113816128284824240328071911. Online ahead of print.ABSTRACTNeurological disorders impose a significant burden on individuals, leading to disabilities and a reduced quality of life. However, recent years have witnessed remarkable advancements in pharmaceutical interventions aimed at treating these disorders. This review article aims to provide an overview of the latest innovations and breakthroughs in neurological disorder treatment, with a specific focus on key therapeutic areas such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and stroke. This review ...
Source: Epilepsy Curr - April 15, 2024 Category: Neurology Authors: Rimpi Arora Ashish Baldi Source Type: research
Real-world evidence and patient preference for subcutaneous < em > versus < /em > intravenous natalizumab in the treatment of relapsing-remitting multiple sclerosis - initial results from the observational SISTER study
CONCLUSION: Based on current data, there is a trend toward patients' preference for the natalizumab SC route over the IV route, which provides valuable insights into patients' preference for natalizumab RoA in routine care and complements available data from clinical studies with real-world data on SC natalizumab.TRIAL REGISTRATION: This observational (non-interventional) study was registered in the local German PEI register for non-interventional studies (NIS-No. 611) and in the international CTgov register (NCT05304520).PMID:38616781 | PMC:PMC11015759 | DOI:10.1177/17562864241241382 (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Ralf Gold Stephan Schmidt Florian Deisenhammer Jeremias Motte Nils Richter Kirsi Taipale Hans Christian Salmen Christian Bohland Ksenija Schirduan Source Type: research
Revolutionizing Neurological Disorder Treatment: Integrating Innovations in Pharmaceutical Interventions and Advanced Therapeutic Technologies
Curr Pharm Des. 2024 Apr 9. doi: 10.2174/0113816128284824240328071911. Online ahead of print.ABSTRACTNeurological disorders impose a significant burden on individuals, leading to disabilities and a reduced quality of life. However, recent years have witnessed remarkable advancements in pharmaceutical interventions aimed at treating these disorders. This review article aims to provide an overview of the latest innovations and breakthroughs in neurological disorder treatment, with a specific focus on key therapeutic areas such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and stroke. This review ...
Source: Current Pharmaceutical Design - April 15, 2024 Category: Drugs & Pharmacology Authors: Rimpi Arora Ashish Baldi Source Type: research
Influence of manipulative skills on quality of life and activities of daily living in multiple sclerosis
CONCLUSIONS: The findings of this study point to the fact that patients diagnosed with multiple sclerosis have a decrease in prey strength, pinch strength, manipulative dexterity, quality of life and autonomy in activities of daily living compared to the healthy population.PMID:38618668 | DOI:10.33588/rn.7808.2023297 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: S Rodr íguez-Menéndez R M Mart ínez-Piédrola M Men éndez-González M P érez-de-Heredia-Torres Source Type: research
Revolutionizing Neurological Disorder Treatment: Integrating Innovations in Pharmaceutical Interventions and Advanced Therapeutic Technologies
Curr Pharm Des. 2024 Apr 9. doi: 10.2174/0113816128284824240328071911. Online ahead of print.ABSTRACTNeurological disorders impose a significant burden on individuals, leading to disabilities and a reduced quality of life. However, recent years have witnessed remarkable advancements in pharmaceutical interventions aimed at treating these disorders. This review article aims to provide an overview of the latest innovations and breakthroughs in neurological disorder treatment, with a specific focus on key therapeutic areas such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and stroke. This review ...
Source: Epilepsy Curr - April 15, 2024 Category: Neurology Authors: Rimpi Arora Ashish Baldi Source Type: research
Robotic assisted and exoskeleton gait training effect in mental health and fatigue of multiple sclerosis patients. A systematic review and a meta-analysis
CONCLUSIONS: Overall, REAGT seems to have a positive effect to Quality of Life, especially in MS patients' perspective of General and Mental Health and a slight positive effect in depression as measured by PHQ-9.Implications for rehabilitationMultiple Sclerosis (MS) decreases physical and non-physical aspects of patients' quality of life perspective.Rehabilitation strategy must take into consideration the non-physical effects of a training intervention.Robotic and Exoskeleton Gait Training has a positive effect in MS patients' non-physical quality of life and a slight positive effect in depression.PMID:38616570 | DOI:10.10...
Source: Disability and Rehabilitation - April 15, 2024 Category: Rehabilitation Authors: Vasileios N Christodoulou Dimitrios N Varvarousis Georgios Ntritsos Dimitrios Dimopoulos Nikolaos Giannakeas Georgios I Vasileiadis Anastasios Korompilias Avraam Ploumis Source Type: research
Real-world evidence and patient preference for subcutaneous < em > versus < /em > intravenous natalizumab in the treatment of relapsing-remitting multiple sclerosis - initial results from the observational SISTER study
CONCLUSION: Based on current data, there is a trend toward patients' preference for the natalizumab SC route over the IV route, which provides valuable insights into patients' preference for natalizumab RoA in routine care and complements available data from clinical studies with real-world data on SC natalizumab.TRIAL REGISTRATION: This observational (non-interventional) study was registered in the local German PEI register for non-interventional studies (NIS-No. 611) and in the international CTgov register (NCT05304520).PMID:38616781 | PMC:PMC11015759 | DOI:10.1177/17562864241241382 (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Ralf Gold Stephan Schmidt Florian Deisenhammer Jeremias Motte Nils Richter Kirsi Taipale Hans Christian Salmen Christian Bohland Ksenija Schirduan Source Type: research
