Patient With Gender Dysphoria Diagnosed With Multiple Sclerosis Following Takotsubo Cardiomyopathy and Ventricular Arrhythmia: A Case Report and Systematic Literature Review
In this report, we also systematically reviewed published cases of takotsubo cardiomyopathy and MS and found that basal type takotsubo cardiomyopathy was the most common, and most patients presented with brainstem involvement of MS. An awareness of these associations by physicians, along with multidisciplinary collaboration, may facilitate the early diagnosis and improve the prognosis of these patients.PMID:38599863 | DOI:10.2169/internalmedicine.3442-23 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Shinya Yamanaka Mariko Nishihara Madoka Kondo Kotaro Miyata Zhehao Dai Fujimi Kawai Nobuyuki Komiyama Source Type: research
Forthcoming Issues
Multiple Sclerosis and Associated Demyelinating Disorders (Source: Neuroimaging Clinics)
Source: Neuroimaging Clinics - April 10, 2024 Category: Radiology Source Type: research
BTK inhibitor falters in multiple sclerosis trials
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00958-8Findings of phase III trials of the Bruton’s tyrosine kinase inhibitor evobrutinib in patients with relapsing multiple sclerosis were recently presented at the ACTRIMS Forum. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 10, 2024 Category: Neurology Authors: Heather Wood Source Type: research
EBV-specific T cells in multiple sclerosis
Nature Reviews Neurology, Published online: 10 April 2024; doi:10.1038/s41582-024-00959-7New data recently reported at the ACTRIMS Forum add to growing evidence of an aetiological role for Epstein–Barr virus infection in multiple sclerosis. (Source: Nature Reviews Neurology)
Source: Nature Reviews Neurology - April 10, 2024 Category: Neurology Authors: Heather Wood Source Type: research
Multiple sclerosis associated with adalimumab use in ankylosing spondylitis
(Source: Neurological Sciences)
Source: Neurological Sciences - April 10, 2024 Category: Neurology Source Type: research
Spinet-QSM: model-based deep learning with schatten p-norm regularization for improved quantitative susceptibility mapping
ConclusionThe proposed SpiNet-QSM showed a consistent improvement of at least 5% in terms of the high-frequency error norm (HFEN) and normalized root mean squared error (NRMSE) over other QSM reconstruction methods with limited training data. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - April 10, 2024 Category: Materials Science Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Conversion of Astrocyte Cell Lines to Oligodendrocyte Progenitor Cells Using Small Molecules and Transplantation to Animal Model of Multiple Sclerosis
In this study, we present a cocktail of small molecules that target different signaling pathways to promote astrocyte conversion to OPCs. Astrocytes were transferred to an OPC medium and exposed for five days to a small molecule cocktail containing CHIR99021, Forskolin, Repsox, LDN, VPA and Thiazovivin before being preserved in the OPC medium for an additional 10 days. Once reaching the OPC morphology, induced cells underwent immunocytofluorescence evaluation for OPC markers while checked for lacking the astrocyte markers. To test the in vivo differentiation capabilities, induced OPCs were transplanted into demyelinated mi...
Source: Journal of Molecular Neuroscience - April 9, 2024 Category: Neuroscience Source Type: research
Earlier age of symptom onset in younger generation of familial cases of multiple sclerosis
ConclusionIn our study, the analysis of fMS cases across generations, showed an earlier age of symptom onset in the younger generation, even after adjustment. These results indicate the possibility of existence of anticipation phenomenon. (Source: Neurological Sciences)
Source: Neurological Sciences - April 9, 2024 Category: Neurology Source Type: research
The Palliative Care Needs of Patients with Multiple Sclerosis, Parkinson's Related Diseases, and Motor Neurone Disease: A Secondary Analysis of the OPTCARE Neuro Trial Data
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - April 9, 2024 Category: Palliative Care Authors: Mair éad Doherty Emeka Chukwusa Regina McQuillan Faith Cranfield Wei Gao Source Type: research
Conversion of Astrocyte Cell Lines to Oligodendrocyte Progenitor Cells Using Small Molecules and Transplantation to Animal Model of Multiple Sclerosis
In this study, we present a cocktail of small molecules that target different signaling pathways to promote astrocyte conversion to OPCs. Astrocytes were transferred to an OPC medium and exposed for five days to a small molecule cocktail containing CHIR99021, Forskolin, Repsox, LDN, VPA and Thiazovivin before being preserved in the OPC medium for an additional 10 days. Once reaching the OPC morphology, induced cells underwent immunocytofluorescence evaluation for OPC markers while checked for lacking the astrocyte markers. To test the in vivo differentiation capabilities, induced OPCs were transplanted into demyelinated mi...
Source: Journal of Molecular Neuroscience - April 9, 2024 Category: Neuroscience Source Type: research
Cladribine tablets after treatment with natalizumab (CLADRINA) - rationale and design
DISCUSSION: The CLADRINA trial will generate data regarding the safety, efficacy, and immunological impact of the transition from natalizumab to cladribine. As the pace of immunological knowledge of MS continues, insight into disease modifying therapy transition strategies is needed.PMID:38585373 | PMC:PMC10996356 | DOI:10.1177/17562864241233858 (Source: Adv Data)
Source: Adv Data - April 8, 2024 Category: Epidemiology Authors: Peter V Sguigna Rehana Z Hussain Annette Okai Kyle M Blackburn Lauren Tardo Mariam Madinawala Julie Korich Lori A Lebson Jeffrey Kaplan Amber Salter Navid Manouchehri Olaf Stuve Source Type: research
Establishing the Reliability of The Step Test Evaluation of Performance on Stairs (STEPS) in Multiple Sclerosis
CONCLUSIONS: Stair ambulation is a challenging task, integral for mobility and independence, therefore, having a sensitive and valid reliable assessment of stair performance is critical for PwMS. The STEPS assessment is a quick, easily administered, reliable, and valid tool for assessing stair ambulation in PwMS.PMID:38588968 | DOI:10.1016/j.apmr.2024.03.015 (Source: Health Physics)
Source: Health Physics - April 8, 2024 Category: Physics Authors: Patrick G Monaghan Ana M Daugherty Nora E Fritz Source Type: research
Subclinical atherosclerosis in multiple sclerosis
CONCLUSION: MS was not associated with subclinical atherosclerosis.PMID:38585500 | PMC:PMC10998495 | DOI:10.1177/20552173241238627 (Source: Atherosclerosis)
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Ruth Ann Marrie Ronak Patel Stephen Allan Schaffer Source Type: research
