Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
We examined 19 SNPs reported to be in high LD with these alleles in 2,502 healthy subjects included in the 1000 Genomes panel having typed HLA data. Examination of 3 indices (LD R2 values, sensitivity and specificity, minor allele frequency) revealed few SNPs with high tagging performance. All SNPs examined that tag DRB1*15:01 were in perfect LD in the British population; three showed high tagging performance in 4 of the 5 European, and 2 of the 4 American populations. For DQB1*06:02, with no previously validated tag SNPs, we show that rs3135388 has high tagging performance in one South Asian, one American, and one Europea...
Source: Human Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Anne I Boullerne Benjamin Goudey Julien Paganini Michael Erlichster Sujata Gaitonde Douglas L Feinstein Source Type: research
Tralokinumab for the Treatment of Atopic Dermatitis in a Patient with Multiple Sclerosis
Dermatitis. 2024 Apr 4. doi: 10.1089/derm.2024.0038. Online ahead of print.NO ABSTRACTPMID:38574267 | DOI:10.1089/derm.2024.0038 (Source: Dermatitis)
Source: Dermatitis - April 4, 2024 Category: Dermatology Authors: Clara Ure ña-Paniego Trinidad Montero-V ílchez Salvador Arias-Santiago Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on FOXP3 introns
RNA. 2024 Apr 4:rna.079933.123. doi: 10.1261/rna.079933.123. Online ahead of print.ABSTRACTForkhead box P3 (FOXP3) is the master fate-determining transcription factor in regulatory T (Treg) cells and is essential for their development, function and homeostasis. Mutations in FOXP3 cause immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, and aberrant expression of FOXP3 has been implicated in other diseases such as multiple sclerosis and cancer. We previously demonstrated that pre-mRNA splicing of FOXP3 RNAs is highly sen-sitive to levels of DExD-box polypeptide 39B (DDX39B) and here we investigate ...
Source: RNA - April 4, 2024 Category: Genetics & Stem Cells Authors: Chloe K Nagasawa Aaron O Bailey William Russell Mariano A Garcia-Blanco Source Type: research
Tralokinumab for the Treatment of Atopic Dermatitis in a Patient with Multiple Sclerosis
Dermatitis. 2024 Apr 4. doi: 10.1089/derm.2024.0038. Online ahead of print.NO ABSTRACTPMID:38574267 | DOI:10.1089/derm.2024.0038 (Source: Dermatitis)
Source: Dermatitis - April 4, 2024 Category: Dermatology Authors: Clara Ure ña-Paniego Trinidad Montero-V ílchez Salvador Arias-Santiago Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
Tralokinumab for the Treatment of Atopic Dermatitis in a Patient with Multiple Sclerosis
Dermatitis. 2024 Apr 4. doi: 10.1089/derm.2024.0038. Online ahead of print.NO ABSTRACTPMID:38574267 | DOI:10.1089/derm.2024.0038 (Source: Dermatitis)
Source: Dermatitis - April 4, 2024 Category: Dermatology Authors: Clara Ure ña-Paniego Trinidad Montero-V ílchez Salvador Arias-Santiago Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
