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5Z ‐7‐Oxozaenol attenuates cuprizone‐induced demyelination in mice through microglia polarization regulation
ConclusionThese findings suggest that inhibiting TAK1 may be an effective approach for treating demyelinating diseases. (Source: Brain and Behavior)
Source: Brain and Behavior - April 23, 2024 Category: Neurology Authors: Shiyu Chen, Siyao Liu, Yalun Huang, Shiwen Huang, Wanzhou Zhang, Huifang Xie, Lingli Lu Tags: ORIGINAL ARTICLE Source Type: research

Improved quality of life and psychological symptoms following mindfulness and cognitive rehabilitation in multiple sclerosis and their mediating role for cognition: a randomized controlled trial
ConclusionsMBCT and CRT reduced a wide array of psychological symptoms and improved mental QoL. These improvements seemed to impact self-reported cognitive problems after both treatments, whereas objective cognitive improvements after MBCT seemed independent of improvement in psychological symptoms. Future studies should investigate long-term sustainability of these beneficial effects.Trial registrationThe trial was prospectively registered in the Dutch Trial registry on 31 May 2017 (NL6285;https://trialsearch.who.int/Trial2.aspx?TrialID=NTR6459). (Source: Journal of Neurology)
Source: Journal of Neurology - April 23, 2024 Category: Neurology Source Type: research

Cognitive Impairment in Multiple Sclerosis
Cognitive impairment in multiple sclerosis (MS) is common and can have negative effects on quality of life. The clinical presentation can be more subtle and insidious. Thus, cognitive impairment is often underrecognized by both persons with MS (PwMS) and clinicians, leading to underestimation disability due to MS. Recent evidence supports that relapses affect cognition in a similar pattern to other physical relapse symptoms and may be the only symptom of a relapse. Regular screening using validated tests for PwMS will improve the care provided and quality of life of PwMS. (Source: Neuroimaging Clinics)
Source: Neuroimaging Clinics - April 23, 2024 Category: Radiology Authors: Sarah A. Morrow Source Type: research

New Imaging Markers in Multiple Sclerosis and Related Disorders
Concepts of multiple sclerosis (MS) biology continue to evolve, with observations such as “progression independent of disease activity” challenging traditional phenotypic categorization. Iron-sensitive, susceptibility-based imaging techniques are emerging as highly translatable MR imaging sequences that allow for visualization of at least 2 clinically useful biomarkers: the central v ein sign and the paramagnetic rim lesion (PRL). Both biomarkers demonstrate high specificity in the discrimination of MS from other mimics and can be seen at 1.5 T and 3 T field strengths. Additionally, PRLs represent a subset of chronic...
Source: Neuroimaging Clinics - April 23, 2024 Category: Radiology Authors: Christopher C. Hemond, Mar ía I. Gaitán, Martina Absinta, Daniel S. Reich Source Type: research

Advanced Brain Imaging in Central Nervous System Demyelinating Diseases
In recent decades, advances in neuroimaging have profoundly transformed our comprehension of central nervous system demyelinating diseases. Remarkable technological progress has enabled the integration of cutting-edge acquisition and postprocessing techniques, proving instrumental in characterizing subtle focal changes, diffuse microstructural alterations, and macroscopic pathologic processes. This review delves into state-of-the-art modalities applied to multiple sclerosis, neuromyelitis optica spectrum disorders, and myelin oligodendrocyte glycoprotein antibody-associated disease. Furthermore, it explores how this dynami...
Source: Neuroimaging Clinics - April 23, 2024 Category: Radiology Authors: Alessandro Cagol, Charidimos Tsagkas, Cristina Granziera Source Type: research

Meningeal Lymphatics in Central Nervous System Diseases
Annu Rev Neurosci. 2024 Apr 22. doi: 10.1146/annurev-neuro-113023-103045. Online ahead of print.ABSTRACTSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review...
Source: Annual Review of Neuroscience - April 22, 2024 Category: Neurology Authors: Andrea Francesca M Salvador Nora Abduljawad Jonathan Kipnis Source Type: research

Ophthalmological and Neurological Findings in Patients with Idiopathic Uveitis Associated with Retinal Vasculitis and the Relation with the HLA DR15 Allele
CONCLUSION: Although the majority of tested patients was carrying at least one HLA DRB1-15 allele, there was no difference in ophthalmological and neurological findings in both groups.PMID:38648262 | DOI:10.1080/09273948.2024.2316759 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 22, 2024 Category: Allergy & Immunology Authors: Vincent De Man Sophie Bataillie Catherine Cassiman Lise Sels Pieter-Paul Schauwvlieghe Source Type: research

C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research

Remote neuropsychological assessment of patients with neurological disorders and injuries--a study protocol for a cross-sectional case-control validation study
This study protocol describes a cross-sectional study aimed at validating the newly developed digitalized neuropsychological test battery Mindmore Remote in patients with neurological disorders and injuries. Diagnoses comprise traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, brain tumour and epilepsy. 50 patients in each patient group will be included. In addition, 50 healthy controls will be recruited. All participants will undergo both testing with Mindmore Remote at home and traditional neuropsychological assessment face-to-face in a randomised order. The primary outcome is the association ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Berginström, N., Andersson, L. Tags: Open access, Neurology Source Type: research

ENSEMBLE PLUS: final results of shorter ocrelizumab infusion from a randomized controlled trial
ConclusionENSEMBLE PLUS demonstrates the safety and tolerability of shorter ocrelizumab infusions. Most patients remained on/switched to shorter infusion after unblinding; IRRs did not strongly influence patient decisions.Clinical Trials Registration: Substudy of ENSEMBLE (NCT03085810). Registration: March 21, 2017. (Source: Journal of Neurology)
Source: Journal of Neurology - April 22, 2024 Category: Neurology Source Type: research

Dabrafenib mitigates the neuroinflammation caused by ferroptosis in experimental autoimmune encephalomyelitis by up regulating Axl receptor
In this study, we preliminarily studied the possible mechanism of dabrafenib in the treatment of multiple sclerosis from the perspective of ferroptosis. First, we observed that dabrafenib significantly improved symptoms of gait abnormalities, limb weakness or paralysis, and down-regulated levels of spinal cord inflammation in an experimental autoimmune encephalitis (EAE) model. Meanwhile, we also observed that dabrafenib could inhibit the proteins of ferroptosis in spinal cord tissue of EAE mice by western blot. The results of immunohistochemical analysis showed that the effect of dabrafenib on ferroptosis mainly occurred ...
Source: European Journal of Pharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Ning Liu Wuhan Yu Mengjiao Sun Xiaoling Li Wenjing Zhang Manxia Wang Source Type: research