The contribution of EEG to assess and treat motor disorders in multiple sclerosis
CONCLUSIONS: We highlight some key EEG patterns in pwMS at rest and during movement, both suggesting an alteration or disruption of brain connectivity, more specifically involving sensorimotor networks.SIGNIFICANCE: Some of these EEG biomarkers of motor disturbance could be used to design future therapeutic strategies in MS based on neuromodulation approaches, or to predict the effects of motor training and rehabilitation in pwMS.PMID:38643612 | DOI:10.1016/j.clinph.2024.03.024 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - April 21, 2024 Category: Neurology Authors: Benjamin Bardel Samar S Ayache Jean-Pascal Lefaucheur Source Type: research
The contribution of EEG to assess and treat motor disorders in multiple sclerosis
CONCLUSIONS: We highlight some key EEG patterns in pwMS at rest and during movement, both suggesting an alteration or disruption of brain connectivity, more specifically involving sensorimotor networks.SIGNIFICANCE: Some of these EEG biomarkers of motor disturbance could be used to design future therapeutic strategies in MS based on neuromodulation approaches, or to predict the effects of motor training and rehabilitation in pwMS.PMID:38643612 | DOI:10.1016/j.clinph.2024.03.024 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - April 21, 2024 Category: Neurology Authors: Benjamin Bardel Samar S Ayache Jean-Pascal Lefaucheur Source Type: research
Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research
Visual evoked potential in generalized joint hypermobility: A case –control study
ConclusionOur study could reveal VEP changes, especially significant P100 latency in GJH patients without previous neurologic or musculoskeletal disorders. Whether these changes are due to GJH itself or are predictive of inevitable neurologic disease or visual pathway involvement, particularly Multiple Sclerosis needs further investigation with longer follow-up periods. (Source: Brain and Behavior)
Source: Brain and Behavior - April 20, 2024 Category: Neurology Authors: Leila Sadat Mohamadi Jahromi,
Amin Sayyadi,
Aida Askarian,
Alireza Dabbaghmanesh,
Sharareh Roshanzamir Tags: ORIGINAL ARTICLE Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
The role of annexins in central nervous system development and disease
J Mol Med (Berl). 2024 Apr 19. doi: 10.1007/s00109-024-02443-7. Online ahead of print.ABSTRACTAnnexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal central nervous system (CNS) functioning, neurological disorders, and CNS tumors. This paper reviews the roles of individual annexins (A1-A13) in these contexts. Annexins possess unique structural and functional features, such as Ca2+-dependent binding to phospholipids, participating in membrane organization, and modulating cell signaling. They are implicated in various CNS processes, including endocytosis, exocyt...
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Zachary B White Sindhu Nair Markus Bredel Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - April 19, 2024 Category: Allergy & Immunology Authors: Vivien Li, Michele Binder, Anthony W. Purcell, Trevor J. Kilpatrick Tags: Review Article Source Type: research
The role of annexins in central nervous system development and disease
AbstractAnnexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal central nervous system (CNS) functioning, neurological disorders, and CNS tumors. This paper reviews the roles of individual annexins (A1-A13) in these contexts. Annexins possess unique structural and functional features, such as Ca2+-dependent binding to phospholipids, participating in membrane organization, and modulating cell signaling. They are implicated in various CNS processes, including endocytosis, exocytosis, and stabilization of plasma membranes. Annexins exhibit dynamic roles in neurona...
Source: Journal of Molecular Medicine - April 19, 2024 Category: Molecular Biology Source Type: research
Vagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination.
Current treatments for Multiple Sclerosis (MS) poorly address chronic innate neuroinflammation nor do they offer effective remyelination. The vagus nerve has a strong regulatory role in inflammation and Vagus Nerve Stimulation (VNS) has potential to affect both neuroinflammation and remyelination in MS. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 19, 2024 Category: Neurology Authors: Helen Bachmann, Boris Vandemoortele, Vanessa Vermeirssen, Evelien Carrette, Kristl Vonck, Paul Boon, Robrecht Raedt, Guy Laureys Source Type: research
