Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Antibody-Mediated Depletion of Autoreactive T Lymphocytes through PD-1 Improves Disease Outcomes and Visualizes T Cell Activation in Experimental Autoimmune Encephalomyelitis
J Immunol. 2024 Apr 5:ji2300751. doi: 10.4049/jimmunol.2300751. Online ahead of print.ABSTRACTLong-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target for therapeutics for MS. We developed a programmed cell death 1 (PD-1)-targeted radiolabeled mAb and assessed its ability to deplete activated PD-1+ T lymphocytes in vitro and its ability to reduce disease burden of the myelin oligodendrocyte glycoprotein 35-55 experimental autoimmun...
Source: Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Connor Frank Hannah E Salapa Kevin J H Allen Michael C Levin Wojciech Dawicki Ekaterina Dadachova Source Type: research
Circular statistics for analyzing changes in retinal nerve fiber layer
CONCLUSIONS: This paper provides an example of how to use circular statistics in cases of directional data in ophthalmology and demonstrates that circular statistics are a suitable tool for this purpose.PMID:38580212 | DOI:10.1016/j.jcjo.2024.03.002 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Jose M Abalo-Lojo Manuel Arias-Gomez Francisco Gonzalez Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Antibody-Mediated Depletion of Autoreactive T Lymphocytes through PD-1 Improves Disease Outcomes and Visualizes T Cell Activation in Experimental Autoimmune Encephalomyelitis
J Immunol. 2024 Apr 5:ji2300751. doi: 10.4049/jimmunol.2300751. Online ahead of print.ABSTRACTLong-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target for therapeutics for MS. We developed a programmed cell death 1 (PD-1)-targeted radiolabeled mAb and assessed its ability to deplete activated PD-1+ T lymphocytes in vitro and its ability to reduce disease burden of the myelin oligodendrocyte glycoprotein 35-55 experimental autoimmun...
Source: Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Connor Frank Hannah E Salapa Kevin J H Allen Michael C Levin Wojciech Dawicki Ekaterina Dadachova Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Altered EBV specific immune control in multiple sclerosis
Since the 1980s it is known that immune responses to the Epstein-Barr virus (EBV) are elevated in multiple sclerosis (MS) patients. Recent seroepidemiologial data have shown that this alteration after primary EBV infection identifies individuals with a more than 30-fold increased risk to develop MS. The mechanisms by which EBV infection might erode tolerance for the central nervous system (CNS) in these individuals, years prior to clinical MS onset, remain unclear. In this review I will discuss altered frequencies of EBV life cycle stages and their tissue distribution, EBV with CNS autoantigen cross-reactive immune respons...
Source: Journal of Neuroimmunology - April 5, 2024 Category: Allergy & Immunology Authors: Christian M ünz Source Type: research
Risk of hepatitis B virus reactivation in people with multiple sclerosis treated with ocrelizumab: an observational study from Turkey
ConclusionThis study highlights a 14% anti-HBc positivity, indicating a potential risk for HBV reactivation in people with MS receiving ocrelizumab. This suggests the importance of vigilant monitoring and the implementation of prophylactic measures. Our recommendation emphasizes antiviral prophylaxis, particularly for patients with low anti-HBs, and a pre-emptive strategy for others. (Source: Journal of Neurology)
Source: Journal of Neurology - April 5, 2024 Category: Neurology Source Type: research
The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study
ConclusionsWe found that COVID-19-related adversity reduced the HRQoL of PwMS. Our HSU estimates can be used in health economic models to evaluate lockdown cost-effectiveness for people with complex and chronic (mainly neurological) diseases. (Source: Quality of Life Research)
Source: Quality of Life Research - April 5, 2024 Category: Health Management Source Type: research
Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
We examined 19 SNPs reported to be in high LD with these alleles in 2,502 healthy subjects included in the 1000 Genomes panel having typed HLA data. Examination of 3 indices (LD R2 values, sensitivity and specificity, minor allele frequency) revealed few SNPs with high tagging performance. All SNPs examined that tag DRB1*15:01 were in perfect LD in the British population; three showed high tagging performance in 4 of the 5 European, and 2 of the 4 American populations. For DQB1*06:02, with no previously validated tag SNPs, we show that rs3135388 has high tagging performance in one South Asian, one American, and one Europea...
Source: Human Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Anne I Boullerne Benjamin Goudey Julien Paganini Michael Erlichster Sujata Gaitonde Douglas L Feinstein Source Type: research
Tralokinumab for the Treatment of Atopic Dermatitis in a Patient with Multiple Sclerosis
Dermatitis. 2024 Apr 4. doi: 10.1089/derm.2024.0038. Online ahead of print.NO ABSTRACTPMID:38574267 | DOI:10.1089/derm.2024.0038 (Source: Dermatitis)
Source: Dermatitis - April 4, 2024 Category: Dermatology Authors: Clara Ure ña-Paniego Trinidad Montero-V ílchez Salvador Arias-Santiago Source Type: research
The presence of attentional and interpretation biases in patients with severe MS-related fatigue
CONCLUSION: MS patients tend to interpret ambiguous information in a somatically threatening way. This may feed into unhelpful ways of dealing with symptoms, possibly contributing to the perpetuation of severe fatigue in MS.PMID:38575519 | DOI:10.1111/bjhp.12723 (Source: British Journal of Health Psychology)
Source: British Journal of Health Psychology - April 4, 2024 Category: Psychiatry & Psychology Authors: Marieke de Gier Joukje M Oosterman Alicia M Hughes Rona Moss-Morris Colette Hirsch Heleen Beckerman Vincent de Groot Hans Knoop Source Type: research
