Corrigendum to "Influence of mode of delivery on cytokine expression in cord blood" [Hum. Immunol. 80(7) (2019) 533-536].
Corrigendum to "Influence of mode of delivery on cytokine expression in cord blood" [Hum. Immunol. 80(7) (2019) 533-536]. Hum Immunol. 2019 Jul 11;: Authors: Nandanan B, Chua MC, Chiang WC, Goh A, Kumar D, Knippels L, Garssen J, Sandalova E PMID: 31303347 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - July 11, 2019 Category: Allergy & Immunology Authors: Nandanan B, Chua MC, Chiang WC, Goh A, Kumar D, Knippels L, Garssen J, Sandalova E Tags: Hum Immunol Source Type: research

Phenotypic analysis of monocytes and CD4+ T cells in hepatitis E patients with or without pregnancy.
Abstract High mortality in pregnant women is a characteristic of hepatitis E virus (HEV) infection. Role of monocytes/T cells in HEV infection during pregnancy is still unclear. We compared CD14+monocytes and CD4+T cells by flow-cytometry in hepatitis-E patients including 13 pregnant (Antenatal care, ANC), 25 non-ANC patients and respective controls (12 and 20). Non-ANC-patients showed significantly higher frequency of monocytes with increased expression of CD80, CD86 and HLA-DR than control individuals (p 
Source: Human Immunology - July 5, 2019 Category: Allergy & Immunology Authors: Arya RP, Arankalle VA Tags: Hum Immunol Source Type: research

Compelling scientific and clinical evidence that non-HLA specific antibodies impact graft outcome independently and in concert with donor HLA specific antibodies.
PMID: 31279533 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Reinsmoen NL Tags: Hum Immunol Source Type: research

Immunomodulation of human CD19+CD25high regulatory B cells via Th17/Foxp3 regulatory T cells and Th1/Th2 cytokines.
In this study, human CD19+CD25high Breg cells were purified from human peripheral blood. Based on the coculture system of Breg cells and CD4+ T cells in vitro, Breg cells were found to promote the increase in regulatory T (Treg) cells while decreasing the number of Th17 cells. Breg cells regulate Treg cells through two processes: cell-cell contact and cytokines. TGF-βsRII, a blocker of transforming growth factor-β (TGF-β), can attenuate the effects of Treg elevation, suggesting that TGF-β is the main cytokine, while Breg cells rather than interleukin-10 (IL-10) regulate the differentiation of Treg cells...
Source: Human Immunology - June 28, 2019 Category: Allergy & Immunology Authors: Hong M, Liao Y, Liang J, Chen X, Li S, Liu W, Gao C, Zhong Z, Kong D, Deng J, Zhang J, Pan G Tags: Hum Immunol Source Type: research

HLA alleles and haplotypes observed in 263 US families.
ez-Viña MA Abstract The 17th International HLA and Immunogenetics Workshop (IHIW) conducted a project entitled "The Study of Haplotypes in Families by NGS HLA". We investigated the HLA haplotypes of 1017 subjects in 263 nuclear families sourced from five US clinical immunogenetics laboratories, primarily as part of the evaluation of related donor candidates for hematopoietic stem cell and solid organ transplantation. The parents in these families belonged to five broad groups - African (72 parents), Asian (115), European (210), Hispanic (118) and "Other" (11). High-resolution HLA genotyp...
Source: Human Immunology - June 27, 2019 Category: Allergy & Immunology Authors: Osoegawa K, Mallempati KC, Gangavarapu S, Oki A, Gendzekhadze K, Marino SR, Brown NK, Bettinotti MP, Weimer ET, Montero-Martín G, Creary LE, Vayntrub TA, Chang CJ, Askar M, Mack SJ, Fernández-Viña MA Tags: Hum Immunol Source Type: research

pHLA3D: An online database of predicted three-dimensional structures of HLA molecules.
artins Ramos R, Socorro da Silva A Abstract HLA epitope analysis emerged as a strategy to determine alloimmune risk in solid organ transplantation. However, it requires not only knowledge on HLA amino acids sequences, but also on HLA three-dimensional structures. Unfortunately, the number of structures available is still unsatisfactory. This work reports the modelling of 106 heterotrimeric (alpha chain + β2M + peptide) HLA class I molecules. The models were generated by homology modelling using Modeller, refined using GalaxyRefine server, heterodimerized with Swiss-PDB Viewer and, finally, assessed as...
Source: Human Immunology - June 22, 2019 Category: Allergy & Immunology Authors: Menezes Teles E Oliveira D, Melo Santos de Serpa Brandão R, Claudio Demes da Mata Sousa L, das Chagas Alves Lima F, Jamil Hadad do Monte S, Sérgio Coelho Marroquim M, Vanildo de Sousa Lima A, Gilberto Borges Coelho A, Matheus Sousa Costa J, Martins Ramo Tags: Hum Immunol Source Type: research

Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages.
This study evaluated the effect of MUC1 VNTR polymorphisms on activity of the NLRP3 inflammasome in human macrophages, finding that long MUC1 alleles correlated with increased IL-1β production following NLRP3 inflammasome activation. This indicates that the length of MUC1 can influence IL-1β production, thus providing the first evidence of an immune-modulatory role of MUC1 VNTR polymorphisms in human macrophages. PMID: 31213370 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - June 15, 2019 Category: Allergy & Immunology Authors: Dhar P, Sarkar S, Ng GZ, Kalitsis P, Saeed MA, McGuckin MA, Ellis JA, Sutton P Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima.
ez MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the...
Source: Human Immunology - June 14, 2019 Category: Allergy & Immunology Authors: Barquera R, Hernández-Zaragoza DI, Arellano-Prado FP, Goné-Vázquez I, Clayton S, Arrieta-Bolaños E, Escobedo-Ruíz A, García-Arias VE, Bravo-Acevedo A, Rodríguez-López ME, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, Le ón and rural Guanajuato.
Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato. Hum Immunol. 2019 Jun 14;: Authors: Pantoja-Torres JA, Barquera R, Ballesteros-Romero M, Bravo-Acevedo A, Arrieta-Bolaños E, Montiel-Hernández GD, Clayton S, Rodríguez-Rodríguez LI, Hernández-Zaragoza DI, Goné-Vázquez I, Escobedo-Ruíz A, García-Arias VE, Arellano-Prado FP, Rodríguez-López ME, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, ...
Source: Human Immunology - June 14, 2019 Category: Allergy & Immunology Authors: Pantoja-Torres JA, Barquera R, Ballesteros-Romero M, Bravo-Acevedo A, Arrieta-Bolaños E, Montiel-Hernández GD, Clayton S, Rodríguez-Rodríguez LI, Hernández-Zaragoza DI, Goné-Vázquez I, Escobedo-Ruíz A, García-Arias VE, Arellano-Prado FP, Rodrígu Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Nuevo Le ón, Mexico: Monterrey and rural Nuevo León.
Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León. Hum Immunol. 2019 Jun 11;: Authors: Barquera R, Bravo-Acevedo A, Clayton S, Munguía TJR, Hernández-Zaragoza DI, Adalid-Sáinz C, Arrieta-Bolaños E, Aquino-Rubio G, González-Martínez MDR, Lona-Sánchez A, Martínez-Álvarez JC, Arrazola-García MA, Delgado-Aguirre H, González-Medina L, Pacheco-Ubaldo H, Juárez-Barreto V, Benítez-Arvizu G, Escareño-Montiel N, Juárez-de la Cruz F, Jaramillo-Rodr...
Source: Human Immunology - June 11, 2019 Category: Allergy & Immunology Authors: Barquera R, Bravo-Acevedo A, Clayton S, Munguía TJR, Hernández-Zaragoza DI, Adalid-Sáinz C, Arrieta-Bolaños E, Aquino-Rubio G, González-Martínez MDR, Lona-Sánchez A, Martínez-Álvarez JC, Arrazola-García MA, Delgado-Aguirre H, González-Medina L, Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit.
ez MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 161 Mexicans from the state of Nayarit living in Tepic (N = 97) and rural communities (N = 64), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Nayarit include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nay...
Source: Human Immunology - June 11, 2019 Category: Allergy & Immunology Authors: Goné-Vázquez I, Barquera R, Arellano-Prado FP, Hernández-Zaragoza DI, Escobedo-Ruíz A, Clayton S, Arrieta-Bolaños E, García-Arias VE, Rodríguez-López ME, Bravo-Acevedo A, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango.
chez A, González-Martínez MDR, Jaramillo-Rodríguez Y, Salgado-Adame A, la Cruz FJ, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 479 Mexicans from the state of Durango living in Durango city (N = 153) and rural communities (N = 326), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Durango include eight Native American and two European haplotypes. Admixture estimates re...
Source: Human Immunology - June 11, 2019 Category: Allergy & Immunology Authors: González-Medina L, Barquera R, Delgado-Aguirre H, Clayton S, Adalid-Sáinz C, Arrieta-Bolaños E, Pacheco-Ubaldo H, Hernández-Zaragoza DI, Escareño-Montiel N, Morán-Martínez J, Bravo-Acevedo A, Lona-Sánchez A, González-Martínez MDR, Jaramillo-Rodr Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California.
o FP, Martínez-Álvarez JC, García-Arias VE, Rodríguez-López ME, Bravo-Acevedo A, Sánchez-Fernández MGJ, Aguilar-Campos JA, Gómez-Navarro B, Sandoval-Sandoval MJ, Serrano-Osuna R, Yunis EJ, Zúñiga J, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain informat...
Source: Human Immunology - June 11, 2019 Category: Allergy & Immunology Authors: Escobedo-Ruíz A, Barquera R, González-Martín A, Argüelles-San Millán JM, Uribe-Duarte MG, Hernández-Zaragoza DI, Clayton S, Arrieta-Bolaños E, Ruíz-Corral MJ, Goné-Vázquez I, Arellano-Prado FP, Martínez-Álvarez JC, García-Arias VE, Rodríguez Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiac án and rural Sinaloa.
Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa. Hum Immunol. 2019 Jun 11;: Authors: Clayton S, Barquera R, Uribe-Duarte MG, Goné Vázquez I, Zúñiga J, Arrieta-Bolaños E, Hernández-Zaragoza DI, Ruíz-Corral MJ, Escobedo-Ruíz A, Arellano-Prado FP, García-Arias VE, Rodríguez-López ME, Bravo-Acevedo A, Sánchez-Fernández MGJ, Aguilar-Campos JA, Serrano-Osuna R, Gómez-Navarro B, Sandoval-Sandoval MJ, Yunis EJ, Bekker-Méndez C, Granados J Abstract ...
Source: Human Immunology - June 11, 2019 Category: Allergy & Immunology Authors: Clayton S, Barquera R, Uribe-Duarte MG, Goné Vázquez I, Zúñiga J, Arrieta-Bolaños E, Hernández-Zaragoza DI, Ruíz-Corral MJ, Escobedo-Ruíz A, Arellano-Prado FP, García-Arias VE, Rodríguez-López ME, Bravo-Acevedo A, Sánchez-Fernández MGJ, Aguil Tags: Hum Immunol Source Type: research

Identification of the rs9277534 HLA-DP expression marker by next generation sequencing for the selection of unrelated donors for hematopoietic cell transplantation.
Abstract Mismatching of an unrelated donor against a high-expression HLA-DPB1 recipient allele is associated with a high risk of graft-versus-host disease and mortality. The Seattle Cancer Care Alliance (SCCA) and Fred Hutchinson Cancer Research Center transplant program employs an algorithm to match for HLA-A, B, C, DRB1, DQB1 and DPB1 alleles (12/12) and to avoid, whenever possible, donor mismatching against a recipient high-expression HLA-DPB1 allele. HLA-DPB1 expression is associated with the rs9277534 A/G polymorphism located in the 3'UTR of the HLA-DPB1 gene. Next generation sequencing of HLA-DPB1 using the ...
Source: Human Immunology - June 5, 2019 Category: Allergy & Immunology Authors: Balgansuren G, Regen L, Sprague M, Shelton N, Petersdorf E, Hansen JA Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Ju árez and rural Chihuahua.
Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua. Hum Immunol. 2019 Jun 04;: Authors: Pacheco-Ubaldo H, Adalid-Sáinz C, Barquera R, Clayton S, Arrieta-Bolaños E, Delgado-Aguirre H, González-Medina L, Hernández-Zaragoza DI, Escareño-Montiel N, Morán-Martínez J, Bravo-Acevedo A, Lona-Sánchez A, González-Martínez MDR, Jaramillo-Rodríguez Y, Salgado-Adame A, Juárez-de la Cruz F, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J ...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Pacheco-Ubaldo H, Adalid-Sáinz C, Barquera R, Clayton S, Arrieta-Bolaños E, Delgado-Aguirre H, González-Medina L, Hernández-Zaragoza DI, Escareño-Montiel N, Morán-Martínez J, Bravo-Acevedo A, Lona-Sánchez A, González-Martínez MDR, Jaramillo-Rodr Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in a population from Guerrero, Mexico.
nítez-Arvizu G, Vega-Martínez MDR, García-Álvarez R, Martínez-Bezies V, Escutia-González AB, Díaz-López R, Guizar-López GU, Salgado-Galicia N, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two European haplotypes...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Juárez-Nicolás F, Barquera R, Martínez-Álvarez JC, Hernández-Zaragoza DI, Ortega-Yáñez A, Arrieta-Bolaños E, Clayton S, Bravo-Acevedo A, Arrazola-García MA, Immel A, Juárez-Barreto V, Benítez-Arvizu G, Vega-Martínez MDR, García-Álvarez R, Ma Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico.
;lez-Martínez MDR, Lona-Sánchez A, González-Medina L, Escareño-Montiel N, Arrazola-García MA, Juárez-Barreto V, Benítez-Arvizu G, Delgado-Aguirre H, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Jaramillo-Rodríguez Y, Gómez-Navarro B, Salgado-Adame A, Juárez-de la Cruz F, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 95 Mexicans from the state of Aguascalientes to obtain information regarding allelic a...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Bravo-Acevedo A, Barquera R, Arrieta-Bolaños E, Hernández-Zaragoza DI, Clayton S, Goné-Vázquez I, Escobedo-Ruíz A, Pantoja-Torres JA, Adalid-Sáinz C, Pacheco-Ubaldo H, Martínez-Álvarez JC, González-Martínez MDR, Lona-Sánchez A, González-Medina Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in two populations from Michoac án, Mexico: Morelia and rural Michoacán.
Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán. Hum Immunol. 2019 Jun 04;: Authors: Ballesteros-Romero M, Barquera R, Rodríguez-López ME, Hernández-Zaragoza DI, Goné-Vázquez I, Clayton S, Arrieta-Bolaños E, Escobedo-Ruíz A, Pantoja-Torres JA, García-Arias VE, Arellano-Prado FP, Bravo-Acevedo A, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J, Acuña-Alonzo V Abstract We...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Ballesteros-Romero M, Barquera R, Rodríguez-López ME, Hernández-Zaragoza DI, Goné-Vázquez I, Clayton S, Arrieta-Bolaños E, Escobedo-Ruíz A, Pantoja-Torres JA, García-Arias VE, Arellano-Prado FP, Bravo-Acevedo A, Sánchez-Fernández MGJ, Sandoval-S Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonal á, Zapopan and rural Jalisco.
Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonalá, Zapopan and rural Jalisco. Hum Immunol. 2019 Jun 04;: Authors: Bravo-Acevedo A, Escobedo-Ruíz A, Barquera R, Clayton S, García-Arias VE, Arrieta-Bolaños E, Goné-Vázquez I, Hernández-Zaragoza DI, Arellano-Prado FP, Rodríguez-López ME, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HL...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Bravo-Acevedo A, Escobedo-Ruíz A, Barquera R, Clayton S, García-Arias VE, Arrieta-Bolaños E, Goné-Vázquez I, Hernández-Zaragoza DI, Arellano-Prado FP, Rodríguez-López ME, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Tags: Hum Immunol Source Type: research

Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obreg ón, Hermosillo and rural Sonora.
Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obregón, Hermosillo and rural Sonora. Hum Immunol. 2019 Jun 04;: Authors: Uribe-Duarte MG, Aguilar-Campos JA, Barquera R, Bravo-Acevedo A, Clayton S, Arrieta-Bolaños E, Ruíz-Corral MJ, Hernández-Zaragoza DI, Serrano-Osuna R, Yunis EJ, Zúñiga J, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 439 Mexicans from the state of Sonora living in Ciudad Obregón (N = 143), Hermosillo...
Source: Human Immunology - June 4, 2019 Category: Allergy & Immunology Authors: Uribe-Duarte MG, Aguilar-Campos JA, Barquera R, Bravo-Acevedo A, Clayton S, Arrieta-Bolaños E, Ruíz-Corral MJ, Hernández-Zaragoza DI, Serrano-Osuna R, Yunis EJ, Zúñiga J, Bekker-Méndez C, Granados J Tags: Hum Immunol Source Type: research

5-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from the Central Valley.
drigal JA, Marsh SGE, Shaw BE Abstract A total of 221 Costa Rican Mestizos from the Central Valley were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, and -DQB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*08:02:01-DQB1*04:02:01, with an estimated frequency of 2.04%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the popu...
Source: Human Immunology - May 22, 2019 Category: Allergy & Immunology Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Órlich-Pérez P, Arrieta-Molina G, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Tags: Hum Immunol Source Type: research

4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica.
arsh SGE, Shaw BE Abstract A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are avai...
Source: Human Immunology - May 22, 2019 Category: Allergy & Immunology Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Tags: Hum Immunol Source Type: research

4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from Guanacaste.
arsh SGE, Shaw BE Abstract A total of 110 Costa Rican Mestizos from the province of Guanacaste were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*35:12:01-C*04:01:01-DRB1*04:07:01G, with an estimated frequency of 2.73%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reporte...
Source: Human Immunology - May 21, 2019 Category: Allergy & Immunology Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Arrieta-Molina G, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Tags: Hum Immunol Source Type: research

High resolution HLA allele and haplotype frequencies for Arab donors in the Hadassah bone marrow donor registry.
Abstract Five locus allele-level HLA-A, -B, -C, -DRB1, -DQB1 allele and haplotype frequencies have been calculated for almost 29,000 people from three Arab populations that live in Israel and were recruited as donors to the Hadassah bone marrow donor registry. These groups are of Muslim, Christian and Bedouin Arab descent which represent more than 90% of the Arabs that live in Israel. The goal of the study was to describe the HLA genetic profiles of the Hadassah Arab registry donors and investigate the utility of these donors for the local and international hematopoietic stem-cell transplant community. The results...
Source: Human Immunology - May 21, 2019 Category: Allergy & Immunology Authors: Bishara A, Halagan M, Brautbar C, Israel S, Maiers M, Madbouly A Tags: Hum Immunol Source Type: research

Mapping and definition of HLA class I and II serologic epitopes using an unbiased reverse engineering strategy.
Abstract Current models describing HLA epitopes are both theoretical and empirical. Each has limitations yielding discordant results and increasingly complex modeling. The models make a priori assumptions that epitopes must be present only on the mature protein, solvent accessible, on the 'top' (peptide binding surface) of the molecule, restricted to the same class as the antibody, and in the same position on the target allele if reactive to more than one locus. Results obtained counter to these assumptions are routinely discounted. For the 17th International Histocompatibility and Immunogenetics Workshop, we deve...
Source: Human Immunology - May 20, 2019 Category: Allergy & Immunology Authors: Yamamoto F, Wang L, Chang CJ, Tyan DB Tags: Hum Immunol Source Type: research

4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua.
arsh SGE, Shaw BE Abstract A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 2.26%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are a...
Source: Human Immunology - May 20, 2019 Category: Allergy & Immunology Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Moreira-Espinoza MJ, Paredes-Carias E, Vanegas-Padilla Y, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Tags: Hum Immunol Source Type: research

4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from African-Caribbean descent.
arsh SGE, Shaw BE Abstract A total of 102 Costa Ricans of African-Caribbean descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*01:01:01-B*08:01:01-C*07:01:01-DRB1*03:01:01G, with an estimated frequency of 1.96%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are ...
Source: Human Immunology - May 20, 2019 Category: Allergy & Immunology Authors: Arrieta-Bolaños E, Madrigal-Sánchez JJ, Stein JE, Arrieta-Molina G, Grant S, Salazar-Sánchez L, Madrigal JA, Marsh SGE, Shaw BE Tags: Hum Immunol Source Type: research

HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease.
Abstract Kawasaki disease (KD) is a pediatric vasculitis caused by an unknown trigger in genetically susceptible children. The incidence varies widely across genetically diverse populations. Several associations with HLA Class I alleles have been reported in single cohort studies. Using a genetic approach, from the nine single nucleotide variants (SNVs) associated with KD susceptibility in children of European descent, we identified SNVs near the HLA-C (rs6906846) and HLA-B genes (rs2254556) whose association was replicated in a Japanese descent cohort (rs6906846 p = 0.01, rs2254556 p = 0.005). The risk al...
Source: Human Immunology - May 20, 2019 Category: Allergy & Immunology Authors: Shimizu C, Kim J, Eleftherohorinou H, Wright VJ, Hoang LT, Tremoulet AH, Franco A, Hibberd ML, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin LJM, Levin M, Burns JC, Shike H, International Kawasaki Disease Genetic Consortium Tags: Hum Immunol Source Type: research

HLA concordance between hematopoietic stem cell transplantation patients and umbilical cord blood units: Implications for cord blood banking in admixed populations.
In conclusion, increasing diversity over quantity of new cord blood units will improve the cost effectiveness of cord blood banking and health policies regarding hematopoietic stem cell transplantation in admixed populations such as those present in Latin American countries. PMID: 31101373 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - May 14, 2019 Category: Allergy & Immunology Authors: Bravo-Acevedo A, Barquera R, Bekker-Méndez C, Clayton S, Hernández-Zaragoza DI, Benítez-Arvizu G, Guerra-Márquez Á, Juárez-Cortés ED, Arriaga-Perea AJ, Novelo-Garza B Tags: Hum Immunol Source Type: research

Frequencies and significance of HLA genes in Amerindians from Chile Ca ñete Mapuche.
This study may be also useful for medical Mapuche use in Transplantation and HLA and disease Epidemiology. PMID: 31101374 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - May 14, 2019 Category: Allergy & Immunology Authors: Arnaiz-Villena A, Juarez I, Lopez-Nares A, Palacio-Grüber J, Vaquero C, Callado A, Sevillano A, Rey D, Martin-Villa JM Tags: Hum Immunol Source Type: research

The ABCs (DRDQDPs) of the prozone effect in single antigen bead HLA antibody testing: Lessons from our highly sensitized patients.
In this study we describe the frequency, nature, and degree of prozone in a cohort of highly sensitized patients (cPRA ≥ 95%), in whom accurate detection of HLA antibodies and virtual crossmatching is of paramount importance. Sera were tested by the SAB assay ± EDTA treatment, ±1:10 dilution to identify the prozone effect. The relative contribution of complement vs IgM to prozone was assessed using anti-C3d and anti-IgM reporter antibodies, respectively. We found that prozone was very frequent in highly sensitized patients (80%), especially those with a history of previous transplantation (87%). Cl...
Source: Human Immunology - May 9, 2019 Category: Allergy & Immunology Authors: Greenshields AL, Liwski RS Tags: Hum Immunol Source Type: research

M1-macrophage polarization is upregulated in deep vein thrombosis and contributes to the upregulation of adhesion molecules.
Abstract Deep vein thrombosis (DVT) is characterized by high acute fatality rate due to pulmonary embolism and by serious long-term complications. The risk of DVT development is increased in many medical conditions, such as trauma, cancer, and surgery. However, DVT can also occur as an idiopathic disease without clearly identifiable causes. To investigate the pathogenesis of idiopathic DVT, the involvement of circulating monocytes and macrophages was examined. Data showed that circulating monocytes and monocyte-derived macrophages from DVT patients presented significantly elevated M1-polarization, characterized by...
Source: Human Immunology - May 8, 2019 Category: Allergy & Immunology Authors: Pang X, Wang Y, Liu M Tags: Hum Immunol Source Type: research

Clinical relevance of lung-restricted antibodies in lung transplantation.
Abstract Lung transplant is a definitive treatment for several end-stage lung diseases. However, the high incidence of allograft rejection limits the overall survival following lung transplantation. Traditionally, alloimmunity directed against human leukocyte antigens (HLA) has been implicated in transplant rejection. Recently, the clinical impact of non-HLA lung-restricted antibodies (LRA) has been recognized and extensive research has demonstrated that they may play a dominant role in the development of lung allograft rejection. The immunogenic lung-restricted antigens that have been identified include amongst o...
Source: Human Immunology - May 8, 2019 Category: Allergy & Immunology Authors: Akbarpour M, Wu Q, Liu X, Sun H, Lecuona E, Tomic R, Bhorade S, Mohanakumar T, Bharat A Tags: Hum Immunol Source Type: research

Classical HLA alleles are associated with prevalent and persistent cervical high-risk HPV infection in African women.
CONCLUSIONS: In this first study to investigate the association between HLA alleles and persistent hrHPV in African women, we identified important risk alleles that merit further investigation. Our findings provide new insights into risk factors for hrHPV infection in African ancestry women. PMID: 31072753 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - May 6, 2019 Category: Allergy & Immunology Authors: Adebamowo SN, Adeyemo AA, ACCME Research Group as part of the H3Africa Consortium Tags: Hum Immunol Source Type: research

Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox.
eau D Abstract Anti-endothelial cell antibodies (AECAs) have been correlated with increased acute and chronic rejection across all organ types and early graft dysfunction in kidney and heart transplantation. Nevertheless, the lack of appropriate tools and clear criteria for defining injurious versus non-injurious AECAs prohibits their routine inclusion in clinical risk assessments and diagnostic algorithms for antibody mediated injury. Clinical characterization of AECAs is complicated due to the wide range of polymorphic and non-polymorphic antigens expressed across different vascular tissues and the diverse array...
Source: Human Immunology - May 1, 2019 Category: Allergy & Immunology Authors: Jackson AM, Delville M, Lamarthée B, Anglicheau D Tags: Hum Immunol Source Type: research

Relationship between various cytokines implicated in asthma.
Abstract Asthma is a complex disorder involving immunologic, environmental, genetic and other factors. Today, asthma is the most common disease encountered in clinical medicine in both children and adults worldwide. Asthma is characterized by increased responsiveness of the tracheobronchial tree resulting in chronic swelling and inflammation of the airways recognized to be controlled by the T-helper 2 (Th2) lymphocytes, which secrete cytokines to increase the production of IgE by B cells. There are many cytokines implicated in the development of the chronic inflammatory processes that are often observed in asthma....
Source: Human Immunology - May 1, 2019 Category: Allergy & Immunology Authors: Ayakannu R, Abdullah NA, Radhakrishnan AK, Lechimi Raj V, Liam CK Tags: Hum Immunol Source Type: research

Getting on target: Development of the novel, prozone-resistant, dual antibody rapid test (DART) for the LABScreen single antigen bead (SAB) assay.
In conclusion, the DART protocol accurately detects HLA antibodies independent of the prozone effect. Implementation of DART is an easy way to overcome the prozone effect without compromising HLA antibody detection. PMID: 31040048 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - April 27, 2019 Category: Allergy & Immunology Authors: Greenshields A, Bray RA, Gebel HM, Liwski RS Tags: Hum Immunol Source Type: research

Injury derived autoimmunity: Anti-perlecan/LG3 antibodies in transplantation.
ute;bert MJ Abstract Ischemic, immunologic or pharmacological stressors can induce vascular injury and endothelial apoptosis in organ donors, in transplant candidates due to the impact of end stage organ failure on the vasculature, and in association with peri-transplantation events. Vascular injury may shape innate and adaptive immune responses, leading to dysregulation in the balance between tolerance and immunoreactivity to vascular-derived antigens. Mounting evidence shows that the early stages of apoptosis, characterized by the absence of membrane permeabilization, are prone to trigger various modes of interc...
Source: Human Immunology - April 24, 2019 Category: Allergy & Immunology Authors: Dieudé M, Cardinal H, Hébert MJ Tags: Hum Immunol Source Type: research

HLA genetic study from United Arab Emirates (UAE), Abu Dhabi.
Abstract Emiratis belong to the United Arab Emirates (UAE) country. UAE is placed at the East part of the Arabian Peninsula, protruding into the Arabia Gulf and was populated since 130,000 years ago. First humans migrating out of Africa went probably across this territory. HLA-A, -B, -C, -DRB1, -DQB1, -DQA1 were typed in order to obtain HLA profile for clinical, epidemiological and population genetics studies. Twenty different HLA-A, thirty-five HLA-B and twenty-two HLA-C class I alleles were detected; twenty-seven different HLA-DRB1, fourteen HLA-DQB1 and twelve HLA-DQA1 class II alleles were found. Most freque...
Source: Human Immunology - April 24, 2019 Category: Allergy & Immunology Authors: Arnaiz-Villena A, Yafei ZA, Juarez I, Palacio-Gruber J, Mahri AA, Alvares M, Lopez-Nares A, Nieto J, Al Seiari M, Martin-Villa JM, ElGhazali G Tags: Hum Immunol Source Type: research

Proactive treatment of angiotensin receptor antibodies in kidney transplantation with plasma exchange and/or candesartan is safe and associated with excellent graft survival at 4  years: A single centre Australian experience.
Proactive treatment of angiotensin receptor antibodies in kidney transplantation with plasma exchange and/or candesartan is safe and associated with excellent graft survival at 4 years: A single centre Australian experience. Hum Immunol. 2019 Apr 20;: Authors: Carroll RP, Deayton S, Emery T, Munasinghe W, Tsiopelas E, Fleet A, Lake M, Humphreys I, Jalalonmuhali M, Coates PT Abstract High levels of angiotensin receptor antibodies (ATRab) are associated with acute cellular and humoral rejection, vascular occlusion, de novo human leucocyte antigen donor specific antibody (HLA DSA) and poor graft surviv...
Source: Human Immunology - April 20, 2019 Category: Allergy & Immunology Authors: Carroll RP, Deayton S, Emery T, Munasinghe W, Tsiopelas E, Fleet A, Lake M, Humphreys I, Jalalonmuhali M, Coates PT Tags: Hum Immunol Source Type: research

B cells as organizers of immunity in transplantation.
PMID: 31014827 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - April 20, 2019 Category: Allergy & Immunology Authors: Cascalho M Tags: Hum Immunol Source Type: research

Antibodies against Angiotensin II Type 1 and Endothelin A Receptors: Relevance and pathogenicity.
Abstract Antibodies against two G-protein coupled receptors (GPCRs), angiotensin II type 1 receptor (AT1R) and endothelin A receptor (ETAR) are among a growing number of autoantibodies that are found to be associated with allograft dysfunction. AT1R antibodies (AT1Rabs) and ETAR antibodies (ETARabs) have been shown to activate their target receptors and affect signaling pathways. Multiple single center reports have shown an association between presence of these antibodies and acute or chronic rejection and graft loss in kidney, heart, liver, lung and composite tissue transplantations. However, the characteristics ...
Source: Human Immunology - April 19, 2019 Category: Allergy & Immunology Authors: Philogene MC, Johnson T, Vaught AJ, Zakaria S, Fedarko N Tags: Hum Immunol Source Type: research

The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches.
Abstract The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-antigens have been identified that elicit autoimmune responses including collagen V, K-α 1 tubulin, angiotensin type 1 receptor, and endothelin type A receptor, but it is likely that other antigens elicit similar responses. The paradigm for the pathogenesis of these autoimmune responses ...
Source: Human Immunology - April 17, 2019 Category: Allergy & Immunology Authors: Hachem RR Tags: Hum Immunol Source Type: research

Non-Canonical B Cell Functions in Transplantation.
Abstract B cells are differentiated to recognize antigen and respond by producing antibodies. These activities, governed by recognition of ancillary signals, defend the individual against microorganisms and the products of microorganisms and constitute the canonical function of B cells. Despite the unique differentiation (e.g. recombination and mutation of immunoglobulin gene segments) toward this canonical function, B cells can provide other, "non-canonical" functions, such as facilitating of lymphoid organogenesis and remodeling and fashioning T cell repertoires and modifying T cell responses. Some non...
Source: Human Immunology - April 10, 2019 Category: Allergy & Immunology Authors: Platt JL, Cascalho M Tags: Hum Immunol Source Type: research

Angiotensin II Type I Receptor Antibodies in Thoracic Transplantation.
Abstract Angiotensin II type I receptor (AT1R) is a critical player in regulating vasoconstriction, blood pressure, sodium retention. Even though AT1R has limited polymorphism, AT1R antibodies have been detected in several diseases. The role of AT1R antibodies in transplantation is first reported in kidney transplant, and then identified in heart and lung transplants. Mechanical circulatory support devices (MCS) can also stimulate production of AT1R antibodies. AT1R antibodies may negatively impact graft or patient survival through mechanisms independent of the classical complement activation. PMID: 30980862 ...
Source: Human Immunology - April 10, 2019 Category: Allergy & Immunology Authors: Zhang X, Reinsmoen NL Tags: Hum Immunol Source Type: research

A Reverse-Engineering Strategy Utilizing the Integration of Single Antigen Beads and NGS HLA Genotypes to Detect Potential Antibody Inducing Epitopes.
Abstract Central to the idea of antibody recognition is some degree of foreignness of the target antigen compared to the antibody producer. Epitopes are distinct regions on an antigen to which antibody can be elicited and bound. However, for HLA antigens, there is no consensus definition of what represents the minimal functional immunogenic unit of dissimilarity. To assess this in an unbiased way, we developed a reverse engineering software strategy based on donor specific antibodies defined by single antigen beads and full length genomic high resolution HLA typing by NGS of recipients and donors (332 transplant p...
Source: Human Immunology - April 9, 2019 Category: Allergy & Immunology Authors: Chang CJ, Yamamoto F, Tyan DB Tags: Hum Immunol Source Type: research

Deep targeted sequencing reveals the diversity of TRB-CDR3 repertoire in patients with preeclampsia.
This study aimed to determine the immunological characteristics of PE patients and normal pregnancy at the T cell receptor beta-chain (TRB) level by using high-throughput sequencing. High-throughput sequencing was performed to analyze the expression of TRB-CDR3 in circulating T cells. T cells were isolated from 36 healthy pregnant women, 24 patients with severe PE, and 18 patients with moderate PE. Rearranged mRNA sequences were assigned to their germline V, D, and J counterparts, and translated into proper amino acids by the IMGT database. In general, PE samples had more TRB-CDR3 reads and types than those of normal pregn...
Source: Human Immunology - April 6, 2019 Category: Allergy & Immunology Authors: Guo C, Cai R, Cao X, Yang Y, Wang Q, He R, An L, Peng Z, Chen Y, Ni S, Tan X, Han J, Liu X, Lin L, Yu S, Wang X, Wang C, Ma X Tags: Hum Immunol Source Type: research

Complete nucleotide sequence characterization of DRB5 alleles reveals a homogeneous allele group that is distinct from other DRB genes.
ntilde;a MA Abstract Next Generation Sequencing allows for testing and typing of entire genes of the HLA region. A better and comprehensive sequence assessment can be achieved by the inclusion of full gene sequences of all the common alleles at a given locus. The common alleles of DRB5 are under-characterized with the full exon-intron sequence of two alleles available. In the present study the DRB5 genes from 18 subjects alleles were cloned and sequenced; haplotype analysis showed that 17 of them had a single copy of DRB5 and one consanguineous subject was homozygous at all HLA loci. Methodological approaches incl...
Source: Human Immunology - April 4, 2019 Category: Allergy & Immunology Authors: Barsakis K, Babrzadeh F, Chi A, Mallempati K, Pickle W, Mindrinos M, Fernández-Viña MA Tags: Hum Immunol Source Type: research

Endoplasmic reticulum aminopeptidases as a double-faced tool to increase or decrease efficiency of antigen presentation in health and disease.
PMID: 30928619 [PubMed - as supplied by publisher] (Source: Human Immunology)
Source: Human Immunology - March 27, 2019 Category: Allergy & Immunology Authors: Kuśnierczyk P, Stratikos E Tags: Hum Immunol Source Type: research