PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules
Hum Immunol. 2024 Mar 22:110789. doi: 10.1016/j.humimm.2024.110789. Online ahead of print.ABSTRACTPIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantatio...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Benedict M Matern Matthias Niemann Source Type: research

Targeting the adenosine signaling pathway in macrophages for cancer immunotherapy
Hum Immunol. 2024 Mar 22:110774. doi: 10.1016/j.humimm.2024.110774. Online ahead of print.ABSTRACTOne of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Han Yang Zongliang Zhang Kai Zhao Yulian Zhang Xinbao Yin Guanqun Zhu Zhenlin Wang Xuechuan Yan Xueyu Li Tianzhen He Ke Wang Source Type: research

PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules
Hum Immunol. 2024 Mar 22:110789. doi: 10.1016/j.humimm.2024.110789. Online ahead of print.ABSTRACTPIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantatio...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Benedict M Matern Matthias Niemann Source Type: research

Targeting the adenosine signaling pathway in macrophages for cancer immunotherapy
Hum Immunol. 2024 Mar 22:110774. doi: 10.1016/j.humimm.2024.110774. Online ahead of print.ABSTRACTOne of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Han Yang Zongliang Zhang Kai Zhao Yulian Zhang Xinbao Yin Guanqun Zhu Zhenlin Wang Xuechuan Yan Xueyu Li Tianzhen He Ke Wang Source Type: research

PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules
Hum Immunol. 2024 Mar 22:110789. doi: 10.1016/j.humimm.2024.110789. Online ahead of print.ABSTRACTPIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantatio...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Benedict M Matern Matthias Niemann Source Type: research

Targeting the adenosine signaling pathway in macrophages for cancer immunotherapy
Hum Immunol. 2024 Mar 22:110774. doi: 10.1016/j.humimm.2024.110774. Online ahead of print.ABSTRACTOne of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Han Yang Zongliang Zhang Kai Zhao Yulian Zhang Xinbao Yin Guanqun Zhu Zhenlin Wang Xuechuan Yan Xueyu Li Tianzhen He Ke Wang Source Type: research

PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules
Hum Immunol. 2024 Mar 22:110789. doi: 10.1016/j.humimm.2024.110789. Online ahead of print.ABSTRACTPIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantatio...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Benedict M Matern Matthias Niemann Source Type: research

Targeting the adenosine signaling pathway in macrophages for cancer immunotherapy
Hum Immunol. 2024 Mar 22:110774. doi: 10.1016/j.humimm.2024.110774. Online ahead of print.ABSTRACTOne of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Han Yang Zongliang Zhang Kai Zhao Yulian Zhang Xinbao Yin Guanqun Zhu Zhenlin Wang Xuechuan Yan Xueyu Li Tianzhen He Ke Wang Source Type: research

History of clinical intestinal transplantation
Hum Immunol. 2024 Mar 21:110788. doi: 10.1016/j.humimm.2024.110788. Online ahead of print.ABSTRACTThe intestines have been considered the "forbidden organ" for years, and intestinal failure became the last organ failure recognized as such in the medical field. The impossibility of providing adequate nutritional support, turned these patients into recipients of just palliative comfort. In the 1960's, parenteral nutrition appeared as the most reasonable replacement therapy, but the initial success obtained with clinical kidney, heart, liver, lung and pancreas transplantation served as background to explore intestinal transpl...
Source: Human Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Gabriel E Gondolesi Source Type: research

History of clinical intestinal transplantation
Hum Immunol. 2024 Mar 21:110788. doi: 10.1016/j.humimm.2024.110788. Online ahead of print.ABSTRACTThe intestines have been considered the "forbidden organ" for years, and intestinal failure became the last organ failure recognized as such in the medical field. The impossibility of providing adequate nutritional support, turned these patients into recipients of just palliative comfort. In the 1960's, parenteral nutrition appeared as the most reasonable replacement therapy, but the initial success obtained with clinical kidney, heart, liver, lung and pancreas transplantation served as background to explore intestinal transpl...
Source: Human Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Gabriel E Gondolesi Source Type: research

Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection
CONCLUSION: We show that ITx rejection is associated with increased polarized cells that express a Th17-like phenotype concurrent with regulatory purinergic markers.PMID:38494386 | DOI:10.1016/j.humimm.2024.110773 (Source: Human Immunology)
Source: Human Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Leonid Belyayev Jiman Kang Mohammed Sadat Katrina Loh Digvijay Patil Vinona Muralidaran Khalid Khan Stuart Kaufman Sukanya Subramanian Yuriy Gusev Krithika Bhuvaneshwar Habtom Ressom Rency Varghese Udeme Ekong Cal S Matsumoto Simon C Robson Thomas M Fishb Source Type: research

Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection
CONCLUSION: We show that ITx rejection is associated with increased polarized cells that express a Th17-like phenotype concurrent with regulatory purinergic markers.PMID:38494386 | DOI:10.1016/j.humimm.2024.110773 (Source: Human Immunology)
Source: Human Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Leonid Belyayev Jiman Kang Mohammed Sadat Katrina Loh Digvijay Patil Vinona Muralidaran Khalid Khan Stuart Kaufman Sukanya Subramanian Yuriy Gusev Krithika Bhuvaneshwar Habtom Ressom Rency Varghese Udeme Ekong Cal S Matsumoto Simon C Robson Thomas M Fishb Source Type: research

Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection
CONCLUSION: We show that ITx rejection is associated with increased polarized cells that express a Th17-like phenotype concurrent with regulatory purinergic markers.PMID:38494386 | DOI:10.1016/j.humimm.2024.110773 (Source: Human Immunology)
Source: Human Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Leonid Belyayev Jiman Kang Mohammed Sadat Katrina Loh Digvijay Patil Vinona Muralidaran Khalid Khan Stuart Kaufman Sukanya Subramanian Yuriy Gusev Krithika Bhuvaneshwar Habtom Ressom Rency Varghese Udeme Ekong Cal S Matsumoto Simon C Robson Thomas M Fishb Source Type: research

Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection
CONCLUSION: We show that ITx rejection is associated with increased polarized cells that express a Th17-like phenotype concurrent with regulatory purinergic markers.PMID:38494386 | DOI:10.1016/j.humimm.2024.110773 (Source: Human Immunology)
Source: Human Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Leonid Belyayev Jiman Kang Mohammed Sadat Katrina Loh Digvijay Patil Vinona Muralidaran Khalid Khan Stuart Kaufman Sukanya Subramanian Yuriy Gusev Krithika Bhuvaneshwar Habtom Ressom Rency Varghese Udeme Ekong Cal S Matsumoto Simon C Robson Thomas M Fishb Source Type: research

Lower NKG2D expression in hepatic natural killer cells predicts poorer prognosis for chronic hepatitis B patients with cirrhosis
CONCLUSIONS: Lower NKG2D expression in intra-hepatic NK cells may be predictive of poorer prognosis of CHB patients with cirrhosis.PMID:38493049 | DOI:10.1016/j.humimm.2024.110775 (Source: Human Immunology)
Source: Human Immunology - March 16, 2024 Category: Allergy & Immunology Authors: Yangqing Ma Dabing Ping Kai Huang Yanyan Tao Yuan Peng Xin Sun Chenghai Liu Source Type: research