Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes
Hum Immunol. 2021 Dec 25:S0198-8859(21)00292-5. doi: 10.1016/j.humimm.2021.12.002. Online ahead of print.ABSTRACTOver the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This software uses theoretically defined polymorphic amino acid configurations, called eplets, for HLA compatibility analysis. Although consideration of eplet mismatch loads has potential for immunological risk stratification of transplant patients, the use of eplet matching in organ allocation algorithms is hindered by lacking knowledge of ...
Source: Human Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Suzanne Bezstarosti Cynthia S M Kramer Frans H J Claas Johan W de Fijter Marlies E J Reinders Sebastiaan Heidt Source Type: research

HLA-DR, -DP, -DQ expression status of parathyroid tissue as a potential parathyroid donor selection criteria and review of literature
CONCLUSION: Expression of HLA class II molecules in parathyroid cells appears to constitute a decisive factor. Despite the lack of clinical outcomes, present data proposes new insight with a detailed understanding of parathyroid immunogenicity. In the future, randomized controlled clinical trials are needed for the accurate assessment of the effect of the varied HLA class II expression profiles in parathyroid tissue.PMID:34955228 | DOI:10.1016/j.humimm.2021.12.003 (Source: Human Immunology)
Source: Human Immunology - December 27, 2021 Category: Allergy & Immunology Authors: Beyza Goncu Emrah Yucesan Yeliz Emine Ersoy Mustafa Erhan Aysan Nur Ozten Kandas Source Type: research

HLA-DR, -DP, -DQ expression status of parathyroid tissue as a potential parathyroid donor selection criteria and review of literature
CONCLUSION: Expression of HLA class II molecules in parathyroid cells appears to constitute a decisive factor. Despite the lack of clinical outcomes, present data proposes new insight with a detailed understanding of parathyroid immunogenicity. In the future, randomized controlled clinical trials are needed for the accurate assessment of the effect of the varied HLA class II expression profiles in parathyroid tissue.PMID:34955228 | DOI:10.1016/j.humimm.2021.12.003 (Source: Human Immunology)
Source: Human Immunology - December 27, 2021 Category: Allergy & Immunology Authors: Beyza Goncu Emrah Yucesan Yeliz Emine Ersoy Mustafa Erhan Aysan Nur Ozten Kandas Source Type: research

Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease
This study aimed to investigate B cell subsets distribution and inhibitory receptor expression on these subsets in GD patients. Peripheral blood was drawn from 41 healthy controls and 46 GD patients (21 patients with moderate GD, 25 patients with severe GD). B cell subset distribution and CD22, CD32b and CD72 expression on B cells were analyzed by flow cytometry. Serum cytokines were examined by enzyme-linked immunosorbent assay (ELISA). Compared with healthy controls, the naïve B cell percentage was increased, while the preswitched memory and conventional memory B cell percentages were decreased. The inhibitory recep...
Source: Human Immunology - December 22, 2021 Category: Allergy & Immunology Authors: Yalei Liu Yu Feng Shasha Tang Lijun Zhang Zhoufeng Huang Xiaoyang Shi Yuanyuan Fang Junpeng Yang Xinru Deng Limin Wang Xiaozhuan Liu Huijuan Yuan Source Type: research

Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease
This study aimed to investigate B cell subsets distribution and inhibitory receptor expression on these subsets in GD patients. Peripheral blood was drawn from 41 healthy controls and 46 GD patients (21 patients with moderate GD, 25 patients with severe GD). B cell subset distribution and CD22, CD32b and CD72 expression on B cells were analyzed by flow cytometry. Serum cytokines were examined by enzyme-linked immunosorbent assay (ELISA). Compared with healthy controls, the naïve B cell percentage was increased, while the preswitched memory and conventional memory B cell percentages were decreased. The inhibitory recep...
Source: Human Immunology - December 22, 2021 Category: Allergy & Immunology Authors: Yalei Liu Yu Feng Shasha Tang Lijun Zhang Zhoufeng Huang Xiaoyang Shi Yuanyuan Fang Junpeng Yang Xinru Deng Limin Wang Xiaozhuan Liu Huijuan Yuan Source Type: research

Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease
This study aimed to investigate B cell subsets distribution and inhibitory receptor expression on these subsets in GD patients. Peripheral blood was drawn from 41 healthy controls and 46 GD patients (21 patients with moderate GD, 25 patients with severe GD). B cell subset distribution and CD22, CD32b and CD72 expression on B cells were analyzed by flow cytometry. Serum cytokines were examined by enzyme-linked immunosorbent assay (ELISA). Compared with healthy controls, the naïve B cell percentage was increased, while the preswitched memory and conventional memory B cell percentages were decreased. The inhibitory recep...
Source: Human Immunology - December 22, 2021 Category: Allergy & Immunology Authors: Yalei Liu Yu Feng Shasha Tang Lijun Zhang Zhoufeng Huang Xiaoyang Shi Yuanyuan Fang Junpeng Yang Xinru Deng Limin Wang Xiaozhuan Liu Huijuan Yuan Source Type: research

Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease
This study aimed to investigate B cell subsets distribution and inhibitory receptor expression on these subsets in GD patients. Peripheral blood was drawn from 41 healthy controls and 46 GD patients (21 patients with moderate GD, 25 patients with severe GD). B cell subset distribution and CD22, CD32b and CD72 expression on B cells were analyzed by flow cytometry. Serum cytokines were examined by enzyme-linked immunosorbent assay (ELISA). Compared with healthy controls, the naïve B cell percentage was increased, while the preswitched memory and conventional memory B cell percentages were decreased. The inhibitory recep...
Source: Human Immunology - December 22, 2021 Category: Allergy & Immunology Authors: Yalei Liu Yu Feng Shasha Tang Lijun Zhang Zhoufeng Huang Xiaoyang Shi Yuanyuan Fang Junpeng Yang Xinru Deng Limin Wang Xiaozhuan Liu Huijuan Yuan Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Aging does not affect calcium response to CCL2 and LPS in human monocytes
Hum Immunol. 2021 Dec 7:S0198-8859(21)00257-3. doi: 10.1016/j.humimm.2021.11.004. Online ahead of print.ABSTRACTMonocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, s...
Source: Human Immunology - December 11, 2021 Category: Allergy & Immunology Authors: Bruno de Jes ús Arellano-Cruz Mar ía de Los Ángeles Vázquez-Prieto Nilda Bel én Fernández-Eufrasio Dvorak Montiel-Condado Genaro Pati ño-López Adriana Garibay-Escobar Adriana Sumoza-Toledo Source Type: research

Role of HLA molecular mismatch in clinical practice
Hum Immunol. 2021 Dec 6:S0198-8859(21)00258-5. doi: 10.1016/j.humimm.2021.11.005. Online ahead of print.ABSTRACTTo date, traditional pre-transplant risk factors have failed to provide accurate risk stratification in transplantation. As a result, the practice of precision medicine remains elusive, resulting in a one-size-fits-all therapeutic approach for most patients. However, recent advancements in the understanding of HLA molecules at the molecular level have revitalized interest in HLA mismatch assessment. This review discusses HLA molecular mismatch as a potential prognostic and predictive biomarker available at the ti...
Source: Human Immunology - December 10, 2021 Category: Allergy & Immunology Authors: Chris Wiebe Peter W Nickerson Source Type: research

Role of HLA molecular mismatch in clinical practice
Hum Immunol. 2021 Dec 6:S0198-8859(21)00258-5. doi: 10.1016/j.humimm.2021.11.005. Online ahead of print.ABSTRACTTo date, traditional pre-transplant risk factors have failed to provide accurate risk stratification in transplantation. As a result, the practice of precision medicine remains elusive, resulting in a one-size-fits-all therapeutic approach for most patients. However, recent advancements in the understanding of HLA molecules at the molecular level have revitalized interest in HLA mismatch assessment. This review discusses HLA molecular mismatch as a potential prognostic and predictive biomarker available at the ti...
Source: Human Immunology - December 10, 2021 Category: Allergy & Immunology Authors: Chris Wiebe Peter W Nickerson Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

The role of immune cells in pulmonary hypertension: Focusing on macrophages
Hum Immunol. 2021 Nov 26:S0198-8859(21)00259-7. doi: 10.1016/j.humimm.2021.11.006. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a life-threatening pathological state with elevated pulmonary arterial pressure, resulting in right ventricular failure and heart functional failure. Analyses of human samples and rodent models of pH support the infiltration of various immune cells, including neutrophils, mast cells, dendritic cells, B-cells, T-cells, and natural killer cells, to the lungs and pulmonary perivascular regions and their involvement in the PH development. There is evidence that macrophages are presente...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Ping Luo Bing Qiu Source Type: research

Not all eplet mismatches are created equal - A cohort study illustrating implications to long-term graft outcomes
Hum Immunol. 2021 Nov 26:S0198-8859(21)00260-3. doi: 10.1016/j.humimm.2021.11.007. Online ahead of print.ABSTRACTWe assessed implications of various eplet-compatibility strategies to death-censored graft failure (DCGF), defined as return to dialysis or re-transplantation, in a base-case scenario from the Scientific Registry of Transplant Recipients. To inform personalized care, we evaluated how recipient, donor, and transplant characteristics affect DCGF by ascending categories of eplet mismatches (EMM), and derived adjusted hazard ratios (HR). The base-case analysis demonstrated 15-year estimated survival probabilities of...
Source: Human Immunology - November 30, 2021 Category: Allergy & Immunology Authors: Somaya Zahran Amelie Bourdiec Xun Zhang Ruth Sapir-Pichhadze Source Type: research

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Hum Immunol. 2021 Nov 20:S0198-8859(21)00254-8. doi: 10.1016/j.humimm.2021.11.001. Online ahead of print.ABSTRACTHeteroclitic antibodies bind to a related antigen with higher affinity than to the immunizing antigen to which they were generated. This uncommon phenomenon is not well characterized for antibodies to HLA antigens. Here we analyzed allosera reactivity from two transplant recipients sensitized to mismatched donor alleles DQB1*06:01 and DQB1*06:02 respectively. Epitope analysis demonstrated the reactivity of both sera was restricted to DQB1*04, 05, and 06 alleles, with a specificity associated with the 55R eplet. ...
Source: Human Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Malek Kamoun Medhat Askar Jane D Kearns Thanh-Mai Bui Michelle Nguyen Nicholas K Brown Rene J Duquesnoy Source Type: research

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Hum Immunol. 2021 Nov 20:S0198-8859(21)00254-8. doi: 10.1016/j.humimm.2021.11.001. Online ahead of print.ABSTRACTHeteroclitic antibodies bind to a related antigen with higher affinity than to the immunizing antigen to which they were generated. This uncommon phenomenon is not well characterized for antibodies to HLA antigens. Here we analyzed allosera reactivity from two transplant recipients sensitized to mismatched donor alleles DQB1*06:01 and DQB1*06:02 respectively. Epitope analysis demonstrated the reactivity of both sera was restricted to DQB1*04, 05, and 06 alleles, with a specificity associated with the 55R eplet. ...
Source: Human Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Malek Kamoun Medhat Askar Jane D Kearns Thanh-Mai Bui Michelle Nguyen Nicholas K Brown Rene J Duquesnoy Source Type: research

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Hum Immunol. 2021 Nov 20:S0198-8859(21)00254-8. doi: 10.1016/j.humimm.2021.11.001. Online ahead of print.ABSTRACTHeteroclitic antibodies bind to a related antigen with higher affinity than to the immunizing antigen to which they were generated. This uncommon phenomenon is not well characterized for antibodies to HLA antigens. Here we analyzed allosera reactivity from two transplant recipients sensitized to mismatched donor alleles DQB1*06:01 and DQB1*06:02 respectively. Epitope analysis demonstrated the reactivity of both sera was restricted to DQB1*04, 05, and 06 alleles, with a specificity associated with the 55R eplet. ...
Source: Human Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Malek Kamoun Medhat Askar Jane D Kearns Thanh-Mai Bui Michelle Nguyen Nicholas K Brown Rene J Duquesnoy Source Type: research

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Hum Immunol. 2021 Nov 20:S0198-8859(21)00254-8. doi: 10.1016/j.humimm.2021.11.001. Online ahead of print.ABSTRACTHeteroclitic antibodies bind to a related antigen with higher affinity than to the immunizing antigen to which they were generated. This uncommon phenomenon is not well characterized for antibodies to HLA antigens. Here we analyzed allosera reactivity from two transplant recipients sensitized to mismatched donor alleles DQB1*06:01 and DQB1*06:02 respectively. Epitope analysis demonstrated the reactivity of both sera was restricted to DQB1*04, 05, and 06 alleles, with a specificity associated with the 55R eplet. ...
Source: Human Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Malek Kamoun Medhat Askar Jane D Kearns Thanh-Mai Bui Michelle Nguyen Nicholas K Brown Rene J Duquesnoy Source Type: research

Immunogenetics of heteroclitic recognition of HLA-DQB1 55R eplet specificity by human alloantibody
Hum Immunol. 2021 Nov 20:S0198-8859(21)00254-8. doi: 10.1016/j.humimm.2021.11.001. Online ahead of print.ABSTRACTHeteroclitic antibodies bind to a related antigen with higher affinity than to the immunizing antigen to which they were generated. This uncommon phenomenon is not well characterized for antibodies to HLA antigens. Here we analyzed allosera reactivity from two transplant recipients sensitized to mismatched donor alleles DQB1*06:01 and DQB1*06:02 respectively. Epitope analysis demonstrated the reactivity of both sera was restricted to DQB1*04, 05, and 06 alleles, with a specificity associated with the 55R eplet. ...
Source: Human Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Malek Kamoun Medhat Askar Jane D Kearns Thanh-Mai Bui Michelle Nguyen Nicholas K Brown Rene J Duquesnoy Source Type: research

T cell subpopulations and cytokine levels in hemodialysis patients
Hum Immunol. 2021 Nov 18:S0198-8859(21)00256-1. doi: 10.1016/j.humimm.2021.11.003. Online ahead of print.ABSTRACTHD patients have impaired adaptive immune responses, which might depend on the primary cause of chronic kidney disease (CKD). We analyzed percentages of T cells subpopulations with the expression of CD69, CD25, CD95, and HLA-DR antigens in HD patients to determine the status of T cell activation. Also, we determined serum levels of cytokines: IL12p70, TNF, IL-10, IL-6, IL-1β, IL-8. HD patients had increased percentages of CD4+CD25+, CD4+CD69+, CD4+HLA-DR+, CD8+CD69+, and CD8+HLA-DR+ cells compared to health...
Source: Human Immunology - November 22, 2021 Category: Allergy & Immunology Authors: Katarzyna A Lisowska Hanna Storoniak Alicja D ębska-Ślizień Source Type: research

T cell subpopulations and cytokine levels in hemodialysis patients
Hum Immunol. 2021 Nov 18:S0198-8859(21)00256-1. doi: 10.1016/j.humimm.2021.11.003. Online ahead of print.ABSTRACTHD patients have impaired adaptive immune responses, which might depend on the primary cause of chronic kidney disease (CKD). We analyzed percentages of T cells subpopulations with the expression of CD69, CD25, CD95, and HLA-DR antigens in HD patients to determine the status of T cell activation. Also, we determined serum levels of cytokines: IL12p70, TNF, IL-10, IL-6, IL-1β, IL-8. HD patients had increased percentages of CD4+CD25+, CD4+CD69+, CD4+HLA-DR+, CD8+CD69+, and CD8+HLA-DR+ cells compared to health...
Source: Human Immunology - November 22, 2021 Category: Allergy & Immunology Authors: Katarzyna A Lisowska Hanna Storoniak Alicja D ębska-Ślizień Source Type: research