Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Cladribine tablets after treatment with natalizumab (CLADRINA) - rationale and design
DISCUSSION: The CLADRINA trial will generate data regarding the safety, efficacy, and immunological impact of the transition from natalizumab to cladribine. As the pace of immunological knowledge of MS continues, insight into disease modifying therapy transition strategies is needed.PMID:38585373 | PMC:PMC10996356 | DOI:10.1177/17562864241233858 (Source: Adv Data)
Source: Adv Data - April 8, 2024 Category: Epidemiology Authors: Peter V Sguigna Rehana Z Hussain Annette Okai Kyle M Blackburn Lauren Tardo Mariam Madinawala Julie Korich Lori A Lebson Jeffrey Kaplan Amber Salter Navid Manouchehri Olaf Stuve Source Type: research
Establishing the Reliability of The Step Test Evaluation of Performance on Stairs (STEPS) in Multiple Sclerosis
CONCLUSIONS: Stair ambulation is a challenging task, integral for mobility and independence, therefore, having a sensitive and valid reliable assessment of stair performance is critical for PwMS. The STEPS assessment is a quick, easily administered, reliable, and valid tool for assessing stair ambulation in PwMS.PMID:38588968 | DOI:10.1016/j.apmr.2024.03.015 (Source: Health Physics)
Source: Health Physics - April 8, 2024 Category: Physics Authors: Patrick G Monaghan Ana M Daugherty Nora E Fritz Source Type: research
Narrative Review on the Use of Cladribine Tablets as Exit Therapy for Stable Elderly Patients with Multiple Sclerosis
Neurol Ther. 2024 Apr 8. doi: 10.1007/s40120-024-00603-y. Online ahead of print.ABSTRACTThe number of ageing people with relapsing multiple sclerosis (RMS) is increasing. The efficacy of disease-modifying therapies (DMTs) for RMS declines with age. Also, older persons with MS may be more susceptible to infections, hospitalisations and malignancy. Aging people with MS have higher rates of comorbidities versus aged-matched controls, increasing the individual risk of disability. We review the therapeutic properties of cladribine tablets (CladT) in ageing people with RMS, with regard to their utility for allowing these individ...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Jerome de Seze Dominique Dive Xavier Ayrignac Giovanni Castelnovo Marianne Payet Amel Rayah Claudio Gobbi Patrick Vermersch Chiara Zecca Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate
CONCLUSIONS: Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.PMID:38587977 | DOI:10.5489/cuaj.8683 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Jenny N Guo Mark A Assmus Nicholas S Dean Matthew S Lee Clarissa Wong Jordan Rich Jessica Helon Mitchell M Huang Amy E Krambeck Source Type: research
The Efficacy of Fingolimod and Interferons in Controlling Disability and Relapse Rate in Patients with Multiple Sclerosis: A Systematic Review and Meta ‑Analysis
Conclusions: The results of this systematic review show that efficacy of interferon and fingolimod in controlling relapse rate and disability is similar.International Journal of Preventive Medicine 14():131, December 2023. | DOI: 10.4103/ijpvm.ijpvm_12_22 Corresponding Author: Dr. Mahsa GhajarzadehE ‑mail: m.ghajarzadeh@gmail.comYou can also search for this author in:PubMed Google Scholar (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - April 8, 2024 Category: International Medicine & Public Health Source Type: research
The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis
This study aimed to determine the pooled prevalence of CIm among adults with RRMS and investigate moderators of prevalence rates. Following prospective registration (PROSPERO; CRD42021281815), electronic databases (Embase, Scopus, Medline, and PsycINFO) were searched from inception until March 2023. Eligible studies reported the prevalence of CIm among adults with RRMS, as determined through standardized neuropsychological testing and defined as evidence of reduced performance across at least two cognitive domains (e.g., processing speed, attention) relative to normative samples, healthy controls, or premorbid estimates. T...
Source: Neuropsychology Review - April 8, 2024 Category: Neuroscience Source Type: research
Narrative Review on the Use of Cladribine Tablets as Exit Therapy for Stable Elderly Patients with Multiple Sclerosis
AbstractThe number of ageing people with relapsing multiple sclerosis (RMS) is increasing. The efficacy of disease-modifying therapies (DMTs) for RMS declines with age. Also, older persons with MS may be more susceptible to infections, hospitalisations and malignancy. Aging people with MS have higher rates of comorbidities versus aged-matched controls, increasing the individual risk of disability. We review the therapeutic properties of cladribine tablets (CladT) in ageing people with RMS, with regard to their utility for allowing these individuals to cease continuous administration of a DMT (i.e. to act as an “exit ther...
Source: Neurology and Therapy - April 8, 2024 Category: Neurology Source Type: research
Accelerated long-term forgetting reveals everyday memory deficits in early-stage multiple sclerosis
ConclusionThe ALF test quantifies SMI in MS-patients. With fatigue as a relevant associated factor, this fills the gap in objectifying SMI in MS for diagnostic purposes. (Source: Journal of Neurology)
Source: Journal of Neurology - April 8, 2024 Category: Neurology Source Type: research
Characterization of cell cycle, inflammation, and oxidative stress signaling role in non-communicable diseases: Insights into genetic variants, microRNAs and pathways
In conclusion, our study elucidates the genetic framework and molecular mechanisms underlying NCDs, offering crucial insights into potential genetic/epigenetic biomarkers for diagnosis and prognosis. The specificity of pathways and related miRNAs in different pathologies highlights promising candidates for further clinical validation, with the potential to advance personalized treatments and alleviate the global burden of NCDs.PMID:38581999 | DOI:10.1016/j.compbiomed.2024.108346 (Source: Atherosclerosis)
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Salvatore D'Antona Danilo Porro Francesca Gallivanone Gloria Bertoli Source Type: research
