Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS)
Natalizumab treatment in relapsing-remitting multiple sclerosis: can we safely personalise treatment intervals? In JNNP, Toorop and coworkers present the results of the NEXT-MS trial, a clinical trial on individualised extended interval dosing (EID) of natalizumab (NTZ) in people with relapsing-remitting multiple sclerosis (RRMS).1 NTZ was one of the first high-efficacy treatments in RRMS, and has remained popular since its introduction in the late 2000s. NTZ is typically administered at a dose of 300 mg every 4 weeks. The two pivotal phase 3 NTZ trials, AFFIRM2 and SENTINEL3 were published back-to-back in the New England ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Koch, M. Tags: Editorial commentaries Source Type: research
Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS)
Conclusions
MS disease activity is adequately controlled with personalised natalizumab EID. Interval extension to a drug trough concentration of 5 µg/mL is likely a safe target to extend natalizumab treatment intervals >6 weeks.
Trial registration number
NCT04225312. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Toorop, A. A., van Lierop, Z. Y., Gelissen, L. M., Hoitsma, E., Zeinstra, E. M., van Rooij, L. C., van Munster, C. E., Vennegoor, A., Mostert, J. P., Wokke, B. H., Kalkers, N. F., Hoogervorst, E. L., van Eijk, J. J., Roosendaal, C. M., Kragt, J. J., Eurel Tags: Editor's choice Multiple sclerosis Source Type: research
