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CGRP-mediated trigeminovascular reactivity in migraine patients treated with erenumab
Introduction Migraine is a highly disabling disorder characterised by recurrent attacks of severe headache (https://ichd-3.org/). The trigeminovascular system and release of calcitonin gene-related peptide (CGRP), a neuromodulator and potent vasodilator, have a crucial role in the pathophysiology of migraine.1 Monoclonal antibodies targeting CGRP (eptinezumab, fremanezumab, galcanezumab) or its receptor (erenumab) are novel prophylactics. Unfortunately, it is currently unknown which mechanisms are underlying the variability in response rates. In addition to spontaneous release during migraine, CGRP can be released from tri...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: de Vries Lentsch, S., Al-Hassany, L., Ferrari, M. D., Terwindt, G. M., MaassenVanDenBrink, A. Tags: PostScript Source Type: research

Molecular analysis of SMARD1 patient-derived cells demonstrates that nonsense-mediated mRNA decay is impaired
Introduction Biallelic mutations in the immunoglobulin μ-binding protein 2 (IGHMBP2) gene lead to motor neuron (MN) degeneration in the brain stem and anterior horns of the spinal cord, causing fatal spinal muscular atrophy with respiratory distress type I (SMARD1). Patients exhibit a certain degree of phenotypic variability that has not been explained.1 No effective therapy is currently available, and understanding the function of IGHMBP2 is crucial for identifying specific disease targets. IGHMBP2 is a DNA/RNA helicase protein involved in different cellular processes, but its precise function is unknown. IGHMBP2 exhib...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Taiana, M., Govoni, A., Salani, S., Kleinschmidt, N., Galli, N., Saladini, M., Ghezzi, S. B., Melzi, V., Bersani, M., Del Bo, R., Muehlemann, O., Bertini, E., Sansone, V., Albamonte, E., Messina, S., Mari, F., Cesaroni, E., Porfiri, L., Tiziano, F. D., Vi Tags: PostScript Source Type: research

Prevalence of unruptured intracranial aneurysms: impact of different definitions - the Tromso Study
Conclusion Prevalence in this study was higher than previously observed in other Western populations and was substantially influenced by definitions according to size and extradural or intradural location. The high prevalence of UIAs sized <5 mm may suggest lower rupture risk than previously estimated. Consensus on more robust and consistent radiological definitions of UIAs is warranted. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Johnsen, L.-H., Herder, M., Vangberg, T., Kloster, R., Ingebrigtsen, T., Isaksen, J. G., Mathiesen, E. B. Tags: Neurosurgery Source Type: research

Increased suicide attempt risk in people with epilepsy in the presence of concurrent psychogenic nonepileptic seizures
Conclusions People with concurrent diagnosis of epilepsy and PNES or PNES alone have significantly increased odds of hospitalisation due to suicide attempt as compared to people with epilepsy alone (152% and 93% increase, respectively). These findings have direct implications for the clinical management of suicide risk in people with epilepsy. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Faiman, I., Hodsoll, J., Young, A. H., Shotbolt, P. Tags: Open access Neuropsychiatry Source Type: research

TEARS: a longitudinal investigation of the prevalence, psychological associations and trajectory of poststroke emotionalism
This study aimed to assess the prevalence and course of PSE over the first year poststroke, and its psychological associations. Methods Consenting stroke survivors who were physically and cognitively able to participate were assessed within 2 weeks, 6 and 12 months of stroke to determine PSE point prevalence using a diagnostic, semistructured PSE interview (Testing Emotionalism After Recent Stroke-Diagnostic Interview). At the same assessments, neuropsychological and disability status were determined using Hospital Anxiety and Depression Scale, Abbreviated Mental Test, National Institute of Health Stroke Scale, Barthel In...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Broomfield, N. M., West, R., Barber, M., Quinn, T. J., Gillespie, D., Walters, M., House, A. Tags: Editor's choice Neuropsychiatry Source Type: research

IVIg-exposure and thromboembolic event risk: findings from the UK Biobank
Background Arterial and venous thromboembolic events (TEEs) have been associated with intravenous Ig use, but the risk has been poorly quantified. We aimed to calculate the risk of TEEs associated with exposure to intravenous Ig. Methods We included participants from UK Biobank recruited over 3 years, data extracted September 2020. The study endpoints were incidence of myocardial infarction, other acute ischaemic heart disease, stroke, pulmonary embolism and other venous embolism and thrombosis. Predictors included known TEE risk factors: age, sex, hypertension, smoking status, type 2 diabetes mellitus, hypercholesterolae...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Kapoor, M., Hunt, I., Spillane, J., Bonnett, L. J., Hutton, E. J., McFadyen, J., Westwood, J.-P., Lunn, M. P., Carr, A. S., Reilly, M. M. Tags: Neuromuscular Source Type: research

Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial
Conclusions Early PB/TURSO prolonged tracheostomy/PAV-free survival and delayed first hospitalisation in ALS. Trial registration number NCT03127514; NCT03488524. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Paganoni, S., Hendrix, S., Dickson, S. P., Knowlton, N., Berry, J. D., Elliott, M. A., Maiser, S., Karam, C., Caress, J. B., Owegi, M. A., Quick, A., Wymer, J., Goutman, S. A., Heitzman, D., Heiman-Patterson, T. D., Jackson, C., Quinn, C., Rothstein, J. D Tags: Open access Neuromuscular Source Type: research

Characterising ALS disease progression according to El Escorial and Gold Coast criteria
Conclusions The GCC broaden the definition of ALS, allowing more patients to participate in trials, while minimally impacting population heterogeneity. Given the large variability per diagnostic category, selecting only specific categories for trials may not result in a more homogeneous study population. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: de Jongh, A. D., Braun, N., Weber, M., van Es, M. A., Masrori, P., Veldink, J. H., van Damme, P., van den Berg, L. H., van Eijk, R. P. A. Tags: Neurodegeneration Source Type: research

Time to first treatment and risk of disability pension in relapsing-remitting multiple sclerosis
Conclusion Early treatment initiation is associated with a reduced risk of disability pension in patients with RRMS. This finding underlines the importance of early diagnosis and treatment on a patient-centred, socioeconomic disability milestone. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Wandall-Holm, M. F., Buron, M. D., Kopp, T. I., Thielen, K., Sellebjerg, F., Magyari, M. Tags: Multiple sclerosis Source Type: research

Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study
Conclusion Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Lie, I. A., Kacar, S., Wesnes, K., Brouwer, I., Kvistad, S. S., Wergeland, S., Holmoy, T., Midgard, R., Bru, A., Edland, A., Eikeland, R., Gosal, S., Harbo, H. F., Kleveland, G., Sorenes, Y. S., Oksendal, N., Varhaug, K. N., Vedeler, C. A., Barkhof, F., T Tags: Open access Multiple sclerosis Source Type: research

Impact of previous disease-modifying treatment on safety and efficacy in patients with MS treated with AHSCT
Conclusion This study provides level 4 evidence that AHSCT in patients previously treated with alemtuzumab, cladribine or rituximab is safe and efficacious. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Kvistad, S. A. S., Burman, J., Lehmann, A. K., Tolf, A., Zjukovskaja, C., Melve, G. K., Bo, L., Torkildsen, O. Tags: Open access Multiple sclerosis Source Type: research

Making sense of phantom limb pain
Phantom limb pain (PLP) impacts the majority of individuals who undergo limb amputation. The PLP experience is highly heterogenous in its quality, intensity, frequency and severity. This heterogeneity, combined with the low prevalence of amputation in the general population, has made it difficult to accumulate reliable data on PLP. Consequently, we lack consensus on PLP mechanisms, as well as effective treatment options. However, the wealth of new PLP research, over the past decade, provides a unique opportunity to re-evaluate some of the core assumptions underlying what we know about PLP and the rationale behind PLP treat...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Schone, H. R., Baker, C. I., Katz, J., Nikolajsen, L., Limakatso, K., Flor, H., Makin, T. R. Tags: Open access Cognitive neurology Source Type: research

Neurocognitive functioning and symptoms across levels of collision and contact in male high school athletes
Conclusion There are minimal observed differences in performance on neurocognitive assessments between collision sport, contact sport and non-contact sport athletes. The repetitive subconcussive head impacts associated with collision sport participation do not appear to negatively affect self-reported symptoms or neurocognitive functioning in current youth athletes. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Oldham, J. R., Howell, D., Lanois, C., Berkner, P., Iverson, G. L., Mannix, R., Meehan, W. Tags: JNNP Patients' choice Cognition Source Type: research

Delirium and the risk of developing dementia: a cohort study of 12 949 patients
Conclusions Our study reinforces the link between delirium and future dementia in a large cohort of patients. It highlights the importance of early recognition of delirium and prevention where possible. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Leighton, S. P., Herron, J. W., Jackson, E., Sheridan, M., Deligianni, F., Cavanagh, J. Tags: Open access Cognition Source Type: research

Stroke outcome of early antiplatelet in post-thrombolysis haemorrhagic infarction
Conclusions Antiplatelet therapy can be safely used between 24 and 48 hours when HI occurs after IVT, and such therapy is associated with reduced risk of END and improved neurological outcome in patients who had an AIS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Zhong, W., Yan, S., Chen, Z., Luo, Z., Chen, Y., Zhang, X., Wu, C., Tang, W., Zhang, X., Wang, Y., Gu, Q., Xu, D., Chen, H., Lou, M., on behalf of the CASE-II Study Group Tags: Cerebrovascular disease Source Type: research