Multiple Sclerosis Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells
Methods Mol Biol. 2024;2782:167-173. doi: 10.1007/978-1-0716-3754-8_13.ABSTRACTMicroglia and oligodendrocyte precursor cells (OPCs) are critical glia subsets in the central nervous system (CNS) and are actively engaged in a body of diseases, such as stroke, Alzheimer's disease, multiple sclerosis, etc. Microglia and OPC serve as compelling tools for the study of CNS diseases as well as the repair and damage of myelin sheath in vitro. In this protocol, we summarized a method which is capable of using the same batch of new-born mice to isolate and culture microglia and OPCs. It integrates the characteristics of practicality,...
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Zihao Li Cun-Jin Zhang Source Type: research

A qualitative study of low-load resistance training with blood flow restriction in people with advanced multiple sclerosis
CONCLUSIONS: Participants found BFR combined with low-load resistance training to be satisfactory (mixed initial expectations), acceptable (comfortable/easy), and impactful (translating to life improvements). Areas for program refinement were identified that should be targeted in future iterations.PMID:38616662 | DOI:10.1080/09593985.2024.2341993 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - April 15, 2024 Category: Physiotherapy Authors: Laura A Swink Wesley A Thornton Kathryn A Nearing Mark M Manago Source Type: research

Influence of manipulative skills on quality of life and activities of daily living in multiple sclerosis
CONCLUSIONS: The findings of this study point to the fact that patients diagnosed with multiple sclerosis have a decrease in prey strength, pinch strength, manipulative dexterity, quality of life and autonomy in activities of daily living compared to the healthy population.PMID:38618668 | DOI:10.33588/rn.7808.2023297 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: S Rodr íguez-Menéndez R M Mart ínez-Piédrola M Men éndez-González M P érez-de-Heredia-Torres Source Type: research

Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis
AbstractExperimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is characterized by demyelination and neurodegeneration triggered by infiltrated autoimmune cells and their interaction with astrocytes and microglia. While neuroinflammation is most common in the spinal cord and brainstem, it is less prevalent in the cerebellum, where it predisposes to rapid disease progression. Because the induction and progression of EAE are tightly regulated by adenosinergic signaling, in the present study we compared the adenosine-producing and -degrading enzymes, ecto-5'-nucleot...
Source: Molecular Neurobiology - April 15, 2024 Category: Neurology Source Type: research

The co-occurrence of multiple sclerosis and bipolar disorder: A case series on clinical and neuroimaging correlates
We describe the clinical profile and neuroimaging findings of four cases of MS with BD. Among them, two patients had multiple mood episodes preceding the neurological symptoms, one had concurrent manic and neurological symptoms, and one had multiple depressive episodes and an isolated steroid-induced manic episode. Frontal and temporal lobes, and Periventricular White Matter were involved in all four cases, and hence may be considered biological substrates of BD in MS. Larger studies are needed to validate the utility of these findings.PMID:38615578 | DOI:10.1016/j.ajp.2024.104041 (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - April 14, 2024 Category: Psychiatry Authors: Harkishan Mamtani Kshiteeja Jain Preethi Reddy Rashmi Arasappa Sundarnag Ganjekar Harish Thippeswamy Maya Bhat M Netravathi Geetha Desai Source Type: research

Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption
AbstractMultiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy therapies (HETs) is increasingly recognized as the best strategy to delay or mitigate disease progression from the earliest stages of the disease and to prevent long-term neurodegeneration. Although there is growing clinical and real-world evidence supporting early HET intervention, foregoing this strategy in favor of a traditional escalation approach prioritizing lower...
Source: Journal of Neurology - April 14, 2024 Category: Neurology Source Type: research