Dalfampridine in the treatment of primary fatigue in patients with multiple sclerosis: a randomized clinical trail
ConclusionThe present study revealed a positive short-term effect of extended-release fampridine on MFIS in PwMS. However, this effect was not significantly superior to the placebo. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 6, 2024 Category: Neurology Source Type: research
Establishing the Reliability of The Step Test Evaluation of Performance on Stairs (STEPS) in Multiple Sclerosis
List of Abbreviations: BW 3MWT, backward 3-meter walk test; BW T25FW, backward timed 25-foot walk; CNS, central nervous system; FW T25FW, forward timed 25-foot walk; HD, Huntingdon's disease; ICC, intraclass correlation coefficient. MFIS, modified fatigue impact scale; Neuro-QOL-fatigue, standardized neurology health-related quality of life-fatigue subscale; PD, Parkinson's disease; PDDS, Patient Determined Disease Steps; PT, physical therapist; PwMS, people with Multiple Sclerosis; RRMS, relapse-remitting Multiple Sclerosis; SDMT, symbol digits modalities test; STEPS, The Step Test Evaluation of Performance on Stairs; TMT...
Source: Archives of Physical Medicine and Rehabilitation - April 6, 2024 Category: Rehabilitation Authors: Patrick G. Monaghan, Ana M. Daugherty, Nora E. Fritz Tags: Original Research Source Type: research
Dalfampridine in the treatment of primary fatigue in patients with multiple sclerosis: a randomized clinical trail
ConclusionThe present study revealed a positive short-term effect of extended-release fampridine on MFIS in PwMS. However, this effect was not significantly superior to the placebo. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 6, 2024 Category: Neurology Source Type: research
The effects of urolithin A on poly I:C-induced microglial activation
Front Cell Neurosci. 2024 Mar 20;18:1343562. doi: 10.3389/fncel.2024.1343562. eCollection 2024.ABSTRACTNeuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a "cytokine storm" in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation and oxidative stress, which can be neurotoxic. Remarkebly, recent studies have shown that certain viruses such as influenza A ...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yakum Benard Mingo Lea Gabele Niklas Lonnemann Bert Br ône Martin Korte Shirin Hosseini Source Type: research
Vitamin D receptor gene BsmI (rs1544410) polymorphism: role in multiple sclerosis and genotype-phenotype correlations
CONCLUSIONS: Our results suggest potential genotype-phenotype correlations for the rs1544410 VDR gene polymorphism in the disease course of MS. Future research on a larger scale is needed to confirm these findings.PMID:38578462 | DOI:10.1007/s11033-024-09369-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Maha Jamoussi Faten Alaya Hela Jamoussi Ghada Baraket Afef Achouri Mariem Ben Mahmoud Saloua Fray Nadia Ben Ali Taieb Messaoud Amel Hannachi Salhi Mohamed Fredj Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Antibody-Mediated Depletion of Autoreactive T Lymphocytes through PD-1 Improves Disease Outcomes and Visualizes T Cell Activation in Experimental Autoimmune Encephalomyelitis
J Immunol. 2024 Apr 5:ji2300751. doi: 10.4049/jimmunol.2300751. Online ahead of print.ABSTRACTLong-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target for therapeutics for MS. We developed a programmed cell death 1 (PD-1)-targeted radiolabeled mAb and assessed its ability to deplete activated PD-1+ T lymphocytes in vitro and its ability to reduce disease burden of the myelin oligodendrocyte glycoprotein 35-55 experimental autoimmun...
Source: Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Connor Frank Hannah E Salapa Kevin J H Allen Michael C Levin Wojciech Dawicki Ekaterina Dadachova Source Type: research
The effects of urolithin A on poly I:C-induced microglial activation
Front Cell Neurosci. 2024 Mar 20;18:1343562. doi: 10.3389/fncel.2024.1343562. eCollection 2024.ABSTRACTNeuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a "cytokine storm" in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation and oxidative stress, which can be neurotoxic. Remarkebly, recent studies have shown that certain viruses such as influenza A ...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Yakum Benard Mingo Lea Gabele Niklas Lonnemann Bert Br ône Martin Korte Shirin Hosseini Source Type: research
Circular statistics for analyzing changes in retinal nerve fiber layer
CONCLUSIONS: This paper provides an example of how to use circular statistics in cases of directional data in ophthalmology and demonstrates that circular statistics are a suitable tool for this purpose.PMID:38580212 | DOI:10.1016/j.jcjo.2024.03.002 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Jose M Abalo-Lojo Manuel Arias-Gomez Francisco Gonzalez Source Type: research
Vitamin D receptor gene BsmI (rs1544410) polymorphism: role in multiple sclerosis and genotype-phenotype correlations
CONCLUSIONS: Our results suggest potential genotype-phenotype correlations for the rs1544410 VDR gene polymorphism in the disease course of MS. Future research on a larger scale is needed to confirm these findings.PMID:38578462 | DOI:10.1007/s11033-024-09369-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Maha Jamoussi Faten Alaya Hela Jamoussi Ghada Baraket Afef Achouri Mariem Ben Mahmoud Saloua Fray Nadia Ben Ali Taieb Messaoud Amel Hannachi Salhi Mohamed Fredj Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: International Journal of Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)
Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5.ABSTRACTChronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators of neuroinflammation. In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such as cell death and inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, mito...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: Pei Qin Ye Sun Liya Li Source Type: research
