Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption
AbstractMultiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy therapies (HETs) is increasingly recognized as the best strategy to delay or mitigate disease progression from the earliest stages of the disease and to prevent long-term neurodegeneration. Although there is growing clinical and real-world evidence supporting early HET intervention, foregoing this strategy in favor of a traditional escalation approach prioritizing lower...
Source: Journal of Neurology - April 14, 2024 Category: Neurology Source Type: research
Dawn of CAR-T cell therapy in autoimmune diseases
Chin Med J (Engl). 2024 Apr 12. doi: 10.1097/CM9.0000000000003111. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in the treatment of hematological malignancies. Based on the immunomodulatory capability of CAR-T cells, efforts have turned toward exploring their potential in treating autoimmune diseases. Bibliometric analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases, covering a range of subtypes such as systemic lupus erythema...
Source: Chinese Medical Journal - April 13, 2024 Category: General Medicine Authors: Yuxin Liu Minghao Dong Yunhui Chu Luoqi Zhou Yunfan You Xiaowei Pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Source Type: research
Dawn of CAR-T cell therapy in autoimmune diseases
Chin Med J (Engl). 2024 Apr 12. doi: 10.1097/CM9.0000000000003111. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in the treatment of hematological malignancies. Based on the immunomodulatory capability of CAR-T cells, efforts have turned toward exploring their potential in treating autoimmune diseases. Bibliometric analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases, covering a range of subtypes such as systemic lupus erythema...
Source: Chinese Medical Journal - April 13, 2024 Category: General Medicine Authors: Yuxin Liu Minghao Dong Yunhui Chu Luoqi Zhou Yunfan You Xiaowei Pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Source Type: research
Mapping brain volume change across time in primary-progressive multiple sclerosis
ConclusionsConstructing age- and gender-related brain volume maps enabled identifying PPMS patients at a higher risk of brain volume loss. Monitoring these high-risk patients may lead to better treatment decisions and improve patient outcomes. (Source: Neuroradiology)
Source: Neuroradiology - April 13, 2024 Category: Radiology Source Type: research
Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity —a potential diagnostic pitfall in patients with MOG-EM/MOGAD
ConclusionsIn some patients with MOG-EM/MOGAD, MOG-IgG is either exclusively or predominantly MOG-IgG3. Thus, the use of IgG1-specific assays might only partly overcome the current limitations of MOG-IgG testing and —just like H+L- and Fcγ-specific testing—might overlook some genuinely seropositive patients. This would have potentially significant consequences for the management of patients with MOG-EM/MOGAD. Given that IgG3 chiefly detects proteins and is a strong activator of complement and other effecto r mechanisms, MOG-IgG3 may be involved in the immunopathogenesis of MOG-EM/MOGAD. Studies on the frequency and dy...
Source: Journal of Neurology - April 13, 2024 Category: Neurology Source Type: research
Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)
Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We ... (Source: BMC Neurology)
Source: BMC Neurology - April 13, 2024 Category: Neurology Authors: Anja Holz, Nadia Obi, Wolfgang Ahrens, Klaus Berger, Barbara Bohn, Hermann Brenner, Beate Fischer, Julia Fricke, Amand F ührer, Sylvia Gastell, Karin Halina Greiser, Volker Harth, Jana-Kristin Heise, Bernd Holleczek, Thomas Keil, Carolina J. Klett-Tammen Tags: Research Source Type: research
Disruption of IFN γ, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells
In this study, we further investigated the importance of IFNγ-, GZMB-, PRF1-, and LYST-associated pathways in CD8+ T cell-mediated suppression. Using the CRISPR-Cas9 ribonucleoprotein transfection system, we first optimized efficient gene knockout while maintaining high viability in primary bulk human CD8+ T cells. Knockout was confirmed through quantitative real-time PCR assays in all cases, combined with flow cytometry where appropriate, as well as confirmation of insertions and/or deletions at genomic target sites. We observed that the knockout of IFNγ, GZMB, PRF1, or LYST, but not the knockout of IL4 or IL5, resulted...
Source: Journal of Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Chakrapani Vemulawada Pranav S Renavikar Michael P Crawford Scott Steward-Tharp Nitin J Karandikar Source Type: research
Inflammation and Physical activity in Multiple Sclerosis patients. A systematic review and meta-analysis
CONCLUSIONS: Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation.PMID:38608788 | DOI:10.1016/j.ctim.2024.103040 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 12, 2024 Category: Complementary Medicine Authors: V Bellisario G Squillacioti F Ghelli M C Monti L Correale C Montomoli R Bono Source Type: research
Disruption of IFN γ, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells
In this study, we further investigated the importance of IFNγ-, GZMB-, PRF1-, and LYST-associated pathways in CD8+ T cell-mediated suppression. Using the CRISPR-Cas9 ribonucleoprotein transfection system, we first optimized efficient gene knockout while maintaining high viability in primary bulk human CD8+ T cells. Knockout was confirmed through quantitative real-time PCR assays in all cases, combined with flow cytometry where appropriate, as well as confirmation of insertions and/or deletions at genomic target sites. We observed that the knockout of IFNγ, GZMB, PRF1, or LYST, but not the knockout of IL4 or IL5, resulted...
Source: Journal of Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Chakrapani Vemulawada Pranav S Renavikar Michael P Crawford Scott Steward-Tharp Nitin J Karandikar Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
Disruption of IFN γ, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells
In this study, we further investigated the importance of IFNγ-, GZMB-, PRF1-, and LYST-associated pathways in CD8+ T cell-mediated suppression. Using the CRISPR-Cas9 ribonucleoprotein transfection system, we first optimized efficient gene knockout while maintaining high viability in primary bulk human CD8+ T cells. Knockout was confirmed through quantitative real-time PCR assays in all cases, combined with flow cytometry where appropriate, as well as confirmation of insertions and/or deletions at genomic target sites. We observed that the knockout of IFNγ, GZMB, PRF1, or LYST, but not the knockout of IL4 or IL5, resulted...
Source: Journal of Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Chakrapani Vemulawada Pranav S Renavikar Michael P Crawford Scott Steward-Tharp Nitin J Karandikar Source Type: research
Inflammation and physical activity in multiple sclerosis patients. A systematic review and meta-analysis
CONCLUSIONS: Persistent, low-grade inflammation in MS could be upregulated by non-pharmacological complementary therapies, in particular by regular aerobic PA that could reduce and positively modulate inflammation.PMID:38608788 | DOI:10.1016/j.ctim.2024.103040 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 12, 2024 Category: Complementary Medicine Authors: V Bellisario G Squillacioti F Ghelli M C Monti L Correale C Montomoli R Bono Source Type: research
The Role of Upper Extremity Motor Function in the Choice of Bladder Management in Those Unable to Volitionally Void due to Neurologic Dysfunction
Urol Clin North Am. 2024 May;51(2):263-275. doi: 10.1016/j.ucl.2024.01.002. Epub 2024 Feb 18.ABSTRACTIt is estimated that 425,000 individuals with neurologic bladder dysfunction (spinal cordinjury, spina bifida and multiple sclerosis) are unable to volitionally void and must rely oncatheter drainage. Upper extremity (UE) motor function is one of the most important factors indetermining the type of bladder management chosen in individuals who cannot volitionally void. Novel bladder management solutions for those with impaired UE motor function and concurrent impairments involitional voiding continue to be an area of need. T...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Michael Juszczak Kazuko Shem Christopher S Elliott Source Type: research
Voiding Phase Dysfunction in Multiple Sclerosis: Contemporary Review of Terminology, Diagnosis, Management, and Future Directions
Urol Clin North Am. 2024 May;51(2):177-185. doi: 10.1016/j.ucl.2024.01.005. Epub 2024 Mar 4.ABSTRACTLower urinary tract symptoms (LUTS) are highly prevalent in individuals with multiple sclerosis (MS). However, assessment of these symptoms is often hindered by vague definitions or absence of screening in asymptomatic patients. It is crucial to exercise caution when applying the non-neurogenic definition of urinary retention in this population. For men with MS experiencing persistent and treatment-resistant LUTS, urodynamic studies should be used to identify the underlying causes of symptoms. Although numerous therapies are...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Catherine Frances Ingram John A Lincoln Rose Khavari Source Type: research
